Traditional Chinese medicine composition for treating phlebitis and preparation method and application thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating phlebitis and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from oldenlandia diffusa, cortex phellodendri, plantain herb, dandelion, herba violae, fructus forsythiae, rhizoma paridis and radix cyathulae. The traditional Chinese medicine composition can be prepared into an oral medicine for treating phlebitis, can effectively treat phlebitis, and has a good treatment effect.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating phlebitis, and a preparation method and application thereof. Background Art

[0002] Phlebitis is caused by the stimulation of different factors on the inner wall of blood vessels, which leads to inflammation of the blood vessel wall, local pain, redness and swelling of the veins, and in severe cases, inflammatory changes such as cord-like local veins and even nodules. Intravenous infusion is a drug administration route for clinical treatment, and phlebitis is a common complication of clinical intravenous medication. Due to the widespread use of various hyperosmotic drugs and chemotherapy drugs, the incidence of phlebitis is on the rise. There are many factors that cause phlebitis caused by intravenous infusion, such as changes in plasma osmotic pressure, particle factors, infusion speed, drug concentration, etc.

[0003] Phlebitis not only causes pain to patients, but also greatly increases the difficulty of nursing work, increases the economic burden on patients, and also affects the treatment effect. Therefore, developing an effective drug for the treatment of phlebitis is currently a research hotspot.

[0004] According to TCM theory, if blood flow in local veins is blocked, blood stasis will occur, and pain will occur; if blood and qi are blocked, the skin will condense, and the distribution of body fluids will be blocked, causing swelling; if blood stasis accumulates inside the body and turns into heat over time, local fever will occur; if veins are damaged, blood will overflow into the skin or blood heat will accumulate inside the body, local redness will occur. Therefore, blood stasis and qi stagnation are the key to causing phlebitis.

[0005] Currently, Chinese medicine patches or ointments are often used to treat phlebitis. This treatment method can easily cause secondary damage to sensitive skin, and the external treatment cycle is relatively long. Summary of the invention

[0006] The purpose of the present invention is to provide an oral medicine for treating phlebitis. The oral medicine of the present invention is prepared by using oldenlandia diffusa, phellodendron amurense, plantain, dandelion, Viola yedoensis, forsythia, paridis and cyathula.

[0007] Specifically, the present invention provides a Chinese medicine composition for treating phlebitis, which is prepared by using the following Chinese herbal medicines in parts by weight:

[0008] Hedyotis diffusa: 680-1020 copies;

[0009] Phellodendron chinense: 270-410 parts;

[0010] Plantain: 340-510 parts;

[0011] Dandelion: 340-510 parts;

[0012] Viola yedoensis: 200-305 copies;

[0013] Forsythia suspensa: 200-305 parts;

[0014] Paris polyphylla: 135-205;

[0015] Rhizoma Cynanchum: 225-340 servings.

[0016] Preferably, the Chinese medicine composition of the present invention is composed of the following Chinese herbal medicines in parts by weight:

[0017] Hedyotis diffusa: 765-935;

[0018] Phellodendron chinense: 305-375 parts;

[0019] Plantain: 380-465 parts;

[0020] Dandelion: 380-465;

[0021] Viola yedoensis: 230-280 parts;

[0022] Forsythia: 230-280 parts;

[0023] Paris polyphylla: 150-190 parts;

[0024] Rhizoma Cyathulae: 250-310 servings.

[0025] In a specific embodiment, the Chinese medicine composition of the present invention is composed of the following Chinese herbal medicines in parts by weight:

[0026] Hedyotis diffusa: 849;

[0027] Phellodendron chinense: 340 parts;

[0028] Plantain: 424;

[0029] Dandelion: 424;

[0030] Viola yedoensis: 255;

[0031] Forsythia suspensa: 255;

[0032] Paris polyphylla: 170 copies;

[0033] Rhizoma Cyathulae: 283 servings.

[0034] The present invention also provides a method for preparing an oral medicine for treating phlebitis using the above-mentioned Chinese medicine composition, comprising the following steps:

[0035] Weigh the above Chinese herbal medicines according to the proportion to obtain a Chinese medicine composition; then add water and decoct twice; wherein the first decoction is decocted with 14 times the amount of water for 1.0 hour, and the second decoction is decocted with 10 times the amount of water for 1.0 hour, the decoction is filtered, and the filtrate is combined;

[0036] The mixture is concentrated under reduced pressure to a clear paste with a relative density of 1.05 to 1.10; dextrin is added, mixed and dried to form granules.

[0037] Hedyotis diffusa Willd., in accordance with the "Anhui Province Traditional Chinese Medicine Preparation Specifications" (2019 Edition), is the dried whole herb of Hedyotis diffusa Willd., a plant of the Rubiaceae family. It is harvested in summer and autumn, impurities are removed, and dried. It clears away heat and detoxifies, promotes blood circulation and relieves pain, and has diuretic and swelling-reducing effects. It is used for appendicitis, pneumonia, bronchitis, urinary tract infection, tonsillitis, and tumors.

[0038] The remaining medicinal materials shall comply with the 2020 edition of the "Chinese Pharmacopoeia".

[0039] Phellodendron chinense Schneid. is a dried bark of the Rutaceae plant. It is commonly known as "Sichuan Phellodendron". After peeling the bark, remove the rough skin and dry it in the sun. It can clear away heat and dampness, purge fire and eliminate steam, detoxify and treat sores. It is used for damp-heat diarrhea, jaundice and red urine, vaginal itching due to vaginal discharge, painful stranguria due to heat, beriberi and paralysis, bone steaming and fatigue fever, night sweats, spermatorrhea, sores and swelling, eczema and wet sores.

[0040] Plantain, the dried whole herb of Plantago asiatica L. or Plantago depressa Willd. of the Plantaginaceae family. It is dug in summer, sand is removed, and dried in the sun. It clears away heat, promotes diuresis, relieves stranguria, eliminates phlegm, cools blood, and detoxifies. It is used for painful stranguria caused by heat, edema and oliguria, diarrhea caused by summer heat and dampness, cough caused by phlegm and heat, vomiting blood and bleeding, and carbuncle, swelling, and sore.

[0041] Dandelion, the dried whole herb of Taraxacummongolicum Hand.-Mazz., Taraxacumborealisinense Kitam. or several plants of the same genus in the Asteraceae family. It is dug when the flowers first bloom from spring to autumn, and then the impurities are removed, washed and dried in the sun. It clears away heat and detoxifies, reduces swelling and resolves stagnation, and is diuretic and relieves stranguria. It is used for carbuncle, breast carbuncle, scrofula, red eyes, sore throat, lung carbuncle, intestinal carbuncle, damp-heat jaundice, and hot stranguria with astringent pain.

[0042] Violayedoensis Makino is the dried whole herb of Violayedoensis Makino, a plant of the Violaceae family. It is harvested in spring and autumn, impurities are removed, and it is dried in the sun. It clears away heat and detoxifies, cools blood and reduces swelling. It is used for carbuncle, carbuncle, erysipelas, and snake bites.

[0043] Forsythia suspensa (Thunb.) Vahl, the dried fruit of the Oleaceae plant Forsythia suspensa (Thunb.) Vahl. The fruit is harvested in autumn when it is just beginning to ripen and still green, and then impurities are removed, steamed, and dried in the sun, and is commonly known as "green forsythia"; the fruit is harvested when it is fully ripe, dried in the sun, and impurities are removed, and is commonly known as "old forsythia". It can clear away heat and detoxify, reduce swelling and resolve stagnation, and evacuate wind-heat. It is used for carbuncle, scrofula, breast carbuncle, erysipelas, wind-heat cold, the initial stage of febrile disease, warm and heat entering the camp, high fever and thirst, coma and rash, and hot stranguria and astringent pain.

[0044] Paris polyphylla is the dried rhizome of Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz. or Paris polyphylla Smith var. chinensis (Franch.) Hara, a plant of the Liliaceae family. It is harvested in autumn, the fibrous roots are removed, washed, and dried in the sun. It clears away heat and detoxifies, relieves swelling and relieves pain, cools the liver and calms convulsions. It is used for furuncles, carbuncle, sore throat, snake and insect bites, injuries from falls, and convulsions.

[0045] Cyathula officinalis Kuan is the dried root of Cyathula officinalis Kuan, a plant of the Amaranthaceae family. It is dug in autumn and winter, the root head, fibrous roots and mud and sand are removed, and it is dried or sun-dried until half dry, piled up to moisten, and then dried or sun-dried. It can remove blood stasis and promote menstruation, open up joints, and promote diuresis and relieve stranguria. It is used for amenorrhea, retained placenta, injuries from falls, rheumatism, foot paralysis and muscle spasm, and hematuria and stranguria.

[0046] Compared with the prior art, the present invention has the following technical effects:

[0047] The invention provides a Chinese medicine composition for treating phlebitis, wherein Hedyotis diffusa is a main medicine for clearing away heat, detoxicating and removing dampness. Phellodendron amurense is a heat-clearing, detoxicating and dampness-drying medicine, and Plantago is a heat-clearing, diuretic and dampness-removing medicine, and the two medicines assist the main medicine and serve as ministers. Taraxacum mongolicum, Herba Lycopodii and Fructus Forsythiae are heat-clearing, detoxicating and swelling-removing and knot-dispersing medicines; Rhizoma Paridis is a heat-clearing, detoxicating and swelling-removing and blood stasis-removing medicines, and the four medicines are adjuvants. Rhizoma Cynoglossi is a blood stasis-removing and meridian-drying medicine, and guides the medicine downward and serves as an adjuvant. All the medicines are used together to play the effects of clearing away heat, removing dampness, detoxicating and meridian-drying medicines.

[0048] The Chinese medicine composition of the invention can clear away heat and dampness, detoxify and unclog the meridians, and can be made into an oral medicine for superficial phlebitis, deep phlebitis and thrombophlebitis. DETAILED DESCRIPTION

[0049] In order to make the purpose, technical scheme and advantages of the present invention clearer, the preferred embodiments of the present invention are further described in detail in conjunction with the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0050] Example 1

[0051] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0052] 849 parts of Hedyotis diffusa, 340 parts of Phellodendron chinense, 424 parts of Plantago, 424 parts of Taraxacum, 255 parts of Viola yedoensis, 255 parts of Forsythia suspensa, 170 parts of Paris polyphylla, and 283 parts of Cyathula capitata.

[0053] The above Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, and the specific steps are as follows:

[0054] The above Chinese medicine composition is decocted twice with water; the first decoction is decocted with 14 times the amount of water for 1.0 hour, and the second decoction is decocted with 10 times the amount of water for 1.0 hour, the decoction is filtered, and the filtrate is combined;

[0055] The mixture is concentrated under reduced pressure to a clear paste with a relative density of 1.05 to 1.10; 8% of the weight of the Chinese herbal medicine in dextrin is added, mixed and dried to form granules.

[0056] Example 2

[0057] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0058] 1020 parts of Hedyotis diffusa, 270 parts of Phellodendron amurense, 510 parts of Plantago, 340 parts of Taraxacum, 305 parts of Viola yedoensis, 200 parts of Forsythia suspensa, 205 parts of Paris polyphylla, 225 parts of Cyathula officinalis

[0059] The above Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared specifically according to the method of Example 1.

[0060] Example 3

[0061] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0062] 680 parts of Hedyotis diffusa, 410 parts of Phellodendron chinense, 340 parts of Plantago, 510 parts of Taraxacum, 200 parts of Viola yedoensis, 305 parts of Forsythia suspensa, 135 parts of Paris polyphylla, and 340 parts of Cyathula capitata.

[0063] The above Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared specifically according to the method of Example 1.

[0064] Example 4

[0065] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0066] 935 parts of Hedyotis diffusa, 305 parts of Phellodendron chinense, 465 parts of Plantago, 380 parts of Taraxacum, 280 parts of Viola yedoensis, 230 parts of Fructus Forsythiae, 150 parts of Paris polyphylla, and 310 parts of Cyathulae.

[0067] The above Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared specifically according to the method of Example 1.

[0068] Example 5

[0069] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0070] 765 parts of Hedyotis diffusa, 375 parts of Phellodendron chinense, 380 parts of Plantago, 465 parts of Taraxacum, 230 parts of Viola yedoensis, 280 parts of Fructus Forsythiae, 190 parts of Paris polyphylla, and 250 parts of Cyathulae.

[0071] The above Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared specifically according to the method of Example 1.

[0072] Comparative Example 1

[0073] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0074] 500 parts of Hedyotis diffusa, 500 parts of Phellodendron chinense, 424 parts of Plantago, 600 parts of Taraxacum, 200 parts of Viola yedoensis, 255 parts of Fructus Forsythiae, 100 parts of Paris polyphylla, and 430 parts of Cyathulae bidentata.

[0075] The above-mentioned Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared according to the method of Example 1.

[0076] Comparative Example 2

[0077] An oral medicine for treating phlebitis, with reference to Example 1, the only difference is that Sophora flavescens is used to replace Phellodendron amurense, and the rest is the same as Example 1.

[0078] Comparative Example 3

[0079] An oral medicine for treating phlebitis, with reference to Example 1, the only difference is that honeysuckle is used to replace forsythia, and the rest is the same as Example 1.

[0080] Comparative Example 4

[0081] A Chinese medicine composition for treating phlebitis, which is prepared by mixing the following Chinese herbal medicines in parts by weight:

[0082] 1019 parts of Hedyotis diffusa, 340 parts of Phellodendron chinense, 424 parts of Plantago, 424 parts of Taraxacum, 255 parts of Viola yedoensis, 255 parts of Forsythia suspensa, and 283 parts of Cyathula capitata.

[0083] The above-mentioned Chinese medicine composition is used to prepare an oral medicine for treating phlebitis, which is prepared according to the method of Example 1.

[0084] Experimental example

[0085] Kunming mice, half male and half female, weighing 18-22g. After 3 days of adaptive feeding, 17.5mg / mL fluorouracil saline solution was slowly injected into the middle and distal third of the right side of the mouse tail vein toward the proximal end at a rate of 0.2mL / 10g. Once a day, by the third day, erythema or edema appeared at the injection site of the mouse tail vein, and the vein became hard, indicating that the model was successfully established.

[0086] The mice with successful modeling were randomly divided into 8 groups according to their body weight, namely, the model group, the Example 1-3 groups, and the Comparative Example 1-4 groups, with 10 mice in each group. In addition, 10 healthy mice were taken as the normal group.

[0087] Each medication group was gavaged with the corresponding oral drugs, with a dosage of 15 g crude drug / kg and a dosage volume of 0.2 mL / 10 g. The normal group and the model group were gavaged with an equal volume of normal saline once a day for 7 consecutive days.

[0088] The left and right tail diameters of the injection sites of each group of mice were recorded before the first administration and 24 hours after the last administration. Blood was then collected from the eyeballs and naturally coagulated at room temperature for 2 hours. The blood was centrifuged at 3000 r / min for 10 minutes and the supernatant was stored in a -80°C refrigerator for ELISA detection of TNF-α.

[0089] The results are shown in Tables 1 and 2

[0090] Table 1 Mouse tail diameter

[0091] Group Tail diameter before first administration Tail diameter 24 hours after the last administration Normal group 2.40±0.16 2.40±0.18 Model Group <![CDATA[2.84±0.06 ** ]]> 2.80±0.08 Example 1 Group <![CDATA[2.80±0.18 ** ]]> <![CDATA[2.46±0.20 ## ]]> Example 2 Group <![CDATA[2.82±0.20 ** ]]> <![CDATA[2.52±0.22 ## ]]> Example 3 Group <![CDATA[2.80±0.16 ** ]]> <![CDATA[2.54±0.18 ## ]]> Comparative Example 1 <![CDATA[2.84±0.22 ** ]]> <![CDATA[2.60±0.18 #△ ]]> Comparative Example 2 <![CDATA[2.80±0.16 ** ]]> <![CDATA[2.68±0.20 #△ ]]> Comparative Example 3 <![CDATA[2.78±0.18 ** ]]> <![CDATA[2.66±0.18 #△ ]]> Comparative Example 4 <![CDATA[2.80±0.20 ** ]]> <![CDATA[2.70±0.22 #△ ]]>

[0092] Note: Compared with the normal group, ** P<0.01; compared with the model group, # P<0.05, ## P<0.01; compared with the Example 1 group, △ P<0.05.

[0093] Table 2 Serum TNF-α values

[0094]

[0095]

[0096] Note: Compared with the normal group, ** P<0.01; compared with the model group, # P<0.05, ##P<0.01; compared with the Example 1 group, △ P<0.05.

[0097] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating phlebitis, characterized in that: The Chinese medicine composition is composed of the following Chinese herbal medicines: Oldenlandia diffusa, Phellodendron chinense, Plantain, Taraxacum, Viola yedoensis, Forsythia suspensa, Paris polyphylla, Cyathula capitata.

2. The Chinese medicine composition for treating phlebitis according to claim 1, characterized in that: The Chinese medicine composition is composed of the following Chinese herbal medicines in parts by weight: Hedyotis diffusa: 680-1020 copies; Phellodendron chinense: 270-410 parts; Plantain: 340-510 parts; Dandelion: 340-510 parts; Viola yedoensis: 200-305 copies; Forsythia suspensa: 200-305 parts; Paris polyphylla: 135-205; Rhizoma Cynanchum: 225-340 servings.

3. The Chinese medicine composition for treating phlebitis according to claim 2, characterized in that: The Chinese medicine composition is composed of the following Chinese herbal medicines in parts by weight: Hedyotis diffusa: 765-935; Phellodendron chinense: 305-375 parts; Plantain: 380-465 parts; Dandelion: 380-465; Viola yedoensis: 230-280 parts; Forsythia: 230-280 parts; Paris polyphylla: 150-190 parts; Rhizoma Cyathulae: 250-310 servings.

4. The Chinese medicine composition for treating phlebitis according to claim 3, characterized in that: The Chinese medicine composition is composed of the following Chinese herbal medicines in parts by weight: Hedyotis diffusa: 849; Phellodendron chinense: 340 parts; Plantain: 424; Dandelion: 424; Viola yedoensis: 255; Forsythia suspensa: 255; Paris polyphylla: 170 copies; Rhizoma Cyathulae: 283 servings.

5. The method for preparing the Chinese medicine composition for treating phlebitis according to any one of claims 1 to 4, characterized in that: The following steps are involved: The above Chinese herbal medicines are weighed in proportion and mixed to obtain the Chinese medicine composition.

6. Use of the Chinese medicinal composition for treating phlebitis according to any one of claims 1 to 4 in the preparation of an oral medicine for treating phlebitis.

7. The use according to claim 6, characterized in that: The preparation method of the oral medicine is to add water to the traditional Chinese medicine composition and decoct it twice; wherein the first decoction is decocted with 14 times the amount of water for 1.0 hour, and the second decoction is decocted with 10 times the amount of water for 1.0 hour, the decoction is filtered, and the filtrate is combined; The mixture is concentrated under reduced pressure to a clear paste with a relative density of 1.05 to 1.10; dextrin is added, mixed and dried to form granules.

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