A sanitary insecticidal composition containing a methoxy acrylate compound and use thereof

Abstract

The present application relates to a kind of sanitary pest insecticide composition, characterized by the effective component of the complex insecticide is composed of A and B, A is the following structural compound, B is one or more of tetrafluorothiofene, tetrafluoromethyl ether chrysanthemum ester, tetrafluorophenyl chrysanthemum ester, methoxy benzyl fluoride chrysanthemum ester, dextrotrans-chloropropargyl chrysanthemum ester, dextrobenzene ether chrysanthemum ester, heptafluoromethyl ether chrysanthemum ester, dextroheptafluoromethyl ether chrysanthemum ester, biological propylene chrysanthemum ester, dextroallyl chrysanthemum ester, rich dextrotrans-propylene chrysanthemum ester, chloroalkyne chrysanthemum ester, dextroamine chrysanthemum ester, amine chrysanthemum ester.The complex weight ratio of A:B is 20:1~1:20, preferably 20:1~1:1, with the characteristics of high efficiency, low toxicity, etc., the complex insecticide is used as sanitary insecticide, fast-acting, complete killing, reduces the amount of application, reduces the irritation of application, delays the generation of pest resistance.A component as lethal agent, no cross resistance, good lethal effect, widely used in hotels, schools, factories, homes and public places, has special effect on the prevention and control of sanitary pests.

Description

TECHNICAL FIELD

[0001] The present application relates to a hygienic insecticide composition, in particular to a hygienic insecticide composition containing a methoxy acrylate compound and application thereof. BACKGROUND

[0002] The pyrethroid used in hygiene has stomach poison, contact killing and fumigation effect, is a good knockdown agent and lethal agent, and is widely used in the field of household hygiene, such as mosquito incense, aerosol, liquid mosquito incense, etc., and is suitable for application in the space spraying of external environment.

[0003] With the wide application of pyrethroids, the hygienic pests have resistance to pyrethroids, and the drug effect is not ideal, and the pests are knocked down and then recovered. In view of this situation, the active components can be selected for compounding, so as to delay the resistance, improve the control effect on hygienic pests, have synergistic effect, reduce the amount of drug compared with single agent, and realize the compound drug combination with good market prospect. SUMMARY

[0004] One of the purposes of the present application is to provide a compound insecticide containing a methoxy acrylate compound and a pyrethroid, which has good insecticidal effect, low drug cost, synergistic effect of compounding and is not easy to produce drug resistance.

[0005] In order to achieve the above purpose, the technical scheme adopted by the present application is as follows:

[0006] A hygienic insecticide composition containing a methoxy acrylate compound, the composition is composed of component A and component B, component A is a methoxy acrylate compound represented by the following structural formula, and B is any one of tetraflumethrin, tefluthrin, bifenthrin, methothrin, d-cis trans-chloropropyl acrylonitrile, d-cis phenyl ether, heptafluthrin, d-cis heptafluthrin, bio acrylonitrile, d-cis allyl nitrile, rich d-cis trans acrylonitrile, chloro acrylonitrile, d-cis amine nitrile and amitraz; component A is compound A represented by the following structural formula

[0007]

[0008] The mass ratio of component A to component B is 20:1 to 1:1.

[0009] The weight ratio of compound A to tetraflumethrin is 15:1 to 2:1;

[0010] The weight ratio of compound A to tefluthrin is 15:1 to 1:1;

[0011] The weight ratio of compound A to bifenthrin is 9:1 to 1:1;

[0012] The weight ratio of Compound A to propetamphos is 10:1 to 2:1.

[0013] The weight ratio of Compound A to trans-chloropropene is 20:1 to 1:1.

[0014] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0015] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0016] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0017] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0018] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0019] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0020] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0021] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0022] The weight ratio of Compound A to bioresmethrin is 8:1 to 2:1.

[0023] A sanitary insecticidal preparation, the preparation taking the composition as an effective active ingredient, which accounts for 0.1% to 30% of the mass of the preparation.

[0024] The preparation also contains adjuvants, which are any one or several of solvents, emulsifiers, dispersants, wetting agents, antifoaming agents, antifreezing agents, preservatives, thickening agents, and water.

[0025] The solvent is selected from one or more of mesitylene, tetramethylbenzene, pentamethylbenzene, ethanol, cyclohexanone, C8-C19 lower alkane solvents, white oil, diesel oil, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylglutaramide, N-methylpyrrolidone, diisopropyl adipate, tributyl citrate, acetyltributyl citrate, isopropyl myristate, isopropyl palmitate, ethylene glycol methyl ether, piperonyl butyl ether, and dodecylbenzene.

[0026] The emulsifier is selected from one or more of styryl phenol polyoxyethylene ether (such as Nonge 600# series), calcium dodecyl benzene sulfonate (such as Nonge 500# of Nanjing Taihua Co., Ltd.), OP series phosphate ester (alkyl phenol polyoxyethylene ether phosphate ester), phenol polyoxyethyl ether phosphate ester (such as 600# phosphate ester of Jiangsu Kaiyuan), benzyl dimethyl phenol polyoxyethyl ether (such as Nonge 400#), Ninge 36# (styryl phenol formaldehyde resin polyoxyethyl ether), styryl phenol polyoxyethyl polypropylene ether (such as Nonge 1600#), ethylene oxide-propylene oxide block copolymer, alkyl phenol polyoxyethylene ether, castor oil polyoxyethylene ether (such as EL series of Jiangsu Kaiyuan), alkyl aryl polyoxypropylene polyoxyethylene ether (such as Nonge 33# of Nanjing Taihua), alkyl aryl polyoxyethylene polyoxypropylene ether (such as Nonge 34# of Nanjing Taihua), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether), fatty alcohol polyoxyethylene ether (such as MOA series of Haian Petrochemical).

[0027] The dispersant is selected from one or more of polycarboxylate (for example, TERSPERSE 2500, produced by Huntsman Corporation, USA), lignin sulfonate, alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl benzene sulfonate calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, alkyl phenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, glycerol fatty acid ester polyoxyethylene ether.

[0028] The wetting agent is selected from one or more of alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl benzene polyoxyethylene ether phosphate, styryl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (for example, TERSPERSE 2425, Huntsman), naphthalene sulfonate (for example, NNO), sodium dodecyl sulfate, Laikanfen BX, wetting penetrant F, sodium dodecyl benzene sulfonate.

[0029] The defoaming agent is selected from one or more of silicone compound, polydimethylsiloxane, C8-10 fatty alcohol compound, C10-20 saturated fatty acid compound.

[0030] The antifreeze agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, urea.

[0031] The preservative is selected from one or more of potassium sorbate, sodium benzoate.

[0032] The thickening agent is selected from one or more of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate.

[0033] The preparation dosage form is aerosol, emulsifiable concentrate, water emulsion, microemulsion, soluble liquid, thermal fogging agent or suspoemulsion.

[0034] Use of the composition or the preparation, use of the composition or the preparation in controlling sanitary pests.

[0035] The sanitary pests are one or more of Culex pipiens pallens, Culex quinquefasciatus, Aedes triseriatus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Armigeres subalbatus, Chironomus, Musca domestica, Muscina stabulans, Chrysomya megacephala, Lucilia cuprina, Lucilia luciita, Fannia scalaris, Fannia canicularis, Cimex lectularius, Pulex irritans, Ixodes persulcatus, Ixodes sinensis, Ixodes persulcatus, Boophilus microplus, Tetranychus urticae and Sarcoptes scabiei.

[0036] The composition or the preparation can be widely used in hotels, schools, factories, families and public places, etc.

[0037] When the insecticide composition is used in controlling sanitary pests, the insecticide composition can be directly used, prepared into an aerosol for direct use in indoor, sprayed into space by using a thermal fogging machine, diluted 20-40 times for spraying into space by using an ultra-low volume device, diluted 20-100 times for spraying into space by using an ultra-low volume device, or sprayed into space by using a constant volume spraying device. DETAILED DESCRIPTION

[0038] The following describes the specific embodiments of the technical scheme of the present application in detail, but the present application is not limited to the following description.

[0039] Example 1

[0040] The composition is a mixture of compound A and methofluthrin, heptafluthrul, tetrafluthrul or other pyrethroids for determining the co-toxicity coefficient:

[0041] Component A is compound A, and component B is a pyrethroid;

[0042]

[0043] Test target: Musca domestica (resistant to local Yangzhou), adult at 3-4 days after eclosion, half male and half female;

[0044] Test method: refer to GB / T26350-2010 "Detection method for insect resistance of flies: biological determination method for Musca domestica" and NY / T1154.7-2006 "Guidelines for indoor biological determination test of pesticides: part 7: determination of combined action of mixtures of insecticides";

[0045] Table 1 Co-toxicity coefficient determination of compound A and methofluthrin (for Musca domestica)

[0046]

[0047] As shown in Table 1, when compound A is mixed with methoxybenzylfluthrin in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies is greater than 120, indicating a synergistic effect. The synergistic effect is most obvious when the ratio is 10:1.

[0048] Table 2. Determination of co-toxicity coefficients of compound A and heptamethrin (for houseflies)

[0049]

[0050]

[0051] As shown in Table 2, when compound A is mixed with heptafluthrin in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies is greater than 120, indicating a synergistic effect. The synergistic effect is most obvious when the ratio is 6:1.

[0052] Table 3. Determination of co-toxicity coefficients of compound A and tetrafluoroethylene (for houseflies)

[0053]

[0054] As shown in Table 3, when compound A is mixed with tetrafluoroethylene in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies is greater than 120, indicating a synergistic effect. The synergistic effect is most obvious when the ratio is 2:1.

[0055] Table 4. Optimal co-toxicity coefficients of compound A with other pyrethroids (against houseflies)

[0056]

[0057]

[0058] As shown in Table 4, the optimal ratio of compound A to other pyrethroids is in the range of 10:1 to 2:1. In particular, the co-toxicity coefficients of tetrafluoromethrin, dextrorotatory trans-cypermethrin, dextrorotatory heptafluoromethrin, and chlorpyrifos all reach over 200, showing a significant synergistic effect.

[0059] The preparation method of the dosage form in Example 2 is as follows:

[0060] The laboratory preparation method of aerosol is as follows: weigh the active ingredient and solvent according to the proportion, heat and mix them evenly in a beaker, cool them, put them into an aerosol can, seal it, and fill it with propane gas to obtain the aerosol.

[0061] The laboratory preparation method of emulsifiable concentrate is as follows: weigh the active ingredient, emulsifier, and solvent in a beaker according to the proportion, heat and mix them evenly, and the emulsifiable concentrate can be obtained.

[0062] The laboratory preparation method of the emulsifiable concentrate is as follows: the active ingredient, the emulsifier, and the solvent are weighed according to the proportion, heated and dissolved to form an oil phase, the antifreezing agent, the defoaming agent, and water are weighed according to the proportion to form an aqueous phase, and the aqueous phase is slowly added to the oil phase under high-speed shearing to obtain the emulsifiable concentrate.

[0063] The laboratory preparation method of the microemulsion is as follows: the active ingredient, the emulsifier, and the solvent are weighed according to the proportion, heated and dissolved completely, and then water is added under stirring to obtain the microemulsion.

[0064] The soluble liquid preparation is prepared by weighing the active ingredient, the emulsifier, and the solvent according to the proportion, heating and dissolving completely.

[0065] The hot fogging agent is prepared by weighing the active ingredient and the solvent according to the proportion, heating and dissolving completely.

[0066] The suspoemulsion is prepared by weighing the liquid active ingredient, the solvent, and the emulsifier according to the proportion, dissolving completely, adding water, stirring uniformly, adding the dispersant, the wetting agent, the solid active ingredient, the antifreezing agent, the thickening agent, the preservative, and the defoaming agent, mixing uniformly, shearing for 5 minutes by a high-speed shearing machine, and then transferring to a sand mill for sand milling for 2-3 hours to control the particle size D90 to be less than 5 μm.

[0067] Preparation Example 1: 16% compound A·tetrafluthrin emulsifiable concentrate

[0068]

[0069]

[0070] Preparation Example 2: 6.5% compound A·tetrafluthrin emulsifiable concentrate

[0071] Compound A 6g Softrane 0.5g N,N-dimethylacetamide 8g Alkylphenol polyoxyethylene ether phosphate 4g Castor oil polyoxyethylene ether 5g Sodium naphthalene sulfonate formaldehyde condensate 1g Propylene glycol 5g Polydimethylsiloxane 0.2g Water q.s. 100 g

[0072] Preparation Example 3: 5% compound A·tetrafluthrin emulsifiable concentrate

[0073] Compound A 4g Softrane 1g Calcium dodecylbenzenesulfonate 6g Castor oil polyoxyethylene ether 15g N-methylpyrrolidone 20g Water q.s. 100 g

[0074] Preparation Example 4: 12% compound A·tetrafluthrin soluble liquid preparation

[0075] Compound A 8g Softrane 4g Oxirane-propylene oxide block copolymer 5g Alkylphenol polyoxyethylene ether 12g Fermase 33 6g N,N-dimethylpropionamide q.s. 100 g

[0076] Preparation Example 5: 0.2% compound A·tetrafluthrin aerosol

[0077] Compound A 0.1g Softrane 0.1g Diisopropyl adipate 5g Odorless kerosene q.s. 50 g Propane gas 50g

[0078] Preparation Example 6: 8% compound A·tetrafluthrin emulsifiable concentrate

[0079]

[0080] Formulation Example 7: 5% Compound A·tetrafluoromethyl ether aqueous emulsion

[0081] Compound A 4.5g Softrane 0.5g N,N-dimethylpropionamide 12g Alkylphenol polyoxyethylene ether phosphate 3g Fermase 36 2g Calcium dodecylbenzenesulfonate 5g Propylene glycol 5g Polydimethylsiloxane 0.2g Water q.s. 100 g

[0082] Formulation Example 8: 7.5% Compound A·tetrafluoromethyl ether pyrethrum microemulsion

[0083] Compound A 7g Softrane 0.5g Calcium dodecylbenzenesulfonate 15g Benzylphenol polyoxyethylene polypropylene ether 6.5g Ethanol 5g Water q.s. 100 g

[0084] Formulation Example 9: 14% Compound A·tetrafluoromethyl ether pyrethrum soluble liquid

[0085] Compound A 12g Softrane 2g Calcium dodecylbenzenesulfonate 10g Castor oil polyoxyethylene ether 6g Tween 80 2g Piperonyl butoxide 3g N,N-dimethylacetamide q.s. 100 g

[0086] Formulation Example 10: 10% Compound A·tetraflurophenothrin emulsifiable concentrate

[0087] Compound A 9g Softrane 1g Calcium dodecylbenzenesulfonate 6g Phenol polyoxyethylene ether 2g Castor oil polyoxyethylene ether 4g Cyclohexanone 6g N,N-dimethylacetamide q.s. 100 g

[0088] Formulation Example 11: 5% Compound A·tetraflurophenothrin aqueous emulsion

[0089] Compound A 4g Softrane 1g Diisopropyl adipate 2g Calcium dodecylbenzenesulfonate 6g Oxirane-propylene oxide block copolymer 4g Castor oil polyoxyethylene ether 2g Glycerol 3g Silicone compound 0.3g Water q.s. 100 g

[0090] Formulation Example 12: 5% Compound A·tetraflurophenothrin microemulsion

[0091] Compound A 2.5g Softrane 2.5g Calcium dodecylbenzenesulfonate 4g Castor oil polyoxyethylene ether 15g Fatty alcohol polyoxyethylene ether 4g N,N-dimethylacetamide 13g Water q.s. 100 g

[0092] Formulation Example 13: 10% Compound A·tetraflurophenothrin soluble liquid

[0093] Compound A 8g Softrane 2g Calcium dodecylbenzenesulfonate 4g Castor oil polyoxyethylene ether 9g Oxirane-propylene oxide block copolymer 5g Acetyltriethyl citrate 10g N,N-dimethylacetamide q.s. 100 g

[0094] Formulation Example 14: 1.5% Compound A·tetraflurophenothrin hot fogging concentrate

[0095] Compound A 1g Softrane 0.5g Ethylene glycol methyl ether 8g White oil q.s. 100 g

[0096] Formulation Example 15: 12% Compound A·tetraflurophenothrin suspoemulsion

[0097]

[0098] Formulation Example 16: 11% Compound A·metofluthrin emulsifiable concentrate

[0099] Compound A 10g Fenobucarb 1g Calcium dodecylbenzenesulfonate 8g Benzyl dimethylphenol polyoxyethylene ether 5g N,N-dimethylacetamide q.s. 100 g

[0100] Formulation Example 17: 0.6% Compound A·metofluthrin aerosol

[0101] Compound A 0.4g Fenobucarb 0.2g Isopropyl palmitate 5g D80 q.s. 50 g Propane gas 50g

[0102] Formulation Example 18: 5% Compound A · esbiothrin aqueous emulsion

[0103] Compound A 4g Fenobucarb 1g N,N-dimethylpropionamide 15g Calcium dodecylbenzenesulfonate 3g Alkylphenol polyoxyethylene ether phosphate 7g Castor oil polyoxyethylene ether 3g Ethylene glycol 5g Polydimethylsiloxane 0.1g Water q.s. 100 g

[0104] Formulation Example 19: 7% Compound A · esbiothrin microemulsion

[0105] Compound A 6g Fenobucarb 1g Calcium dodecylbenzenesulfonate 8g Castor oil polyoxyethylene ether 20g N,N-dimethylacetamide 20g Water q.s. 100 g

[0106] Formulation Example 20: 15% Compound A · esbiothrin soluble liquid

[0107] Compound A 10g Fenobucarb 4g Calcium dodecylbenzenesulfonate 5g Castor oil polyoxyethylene ether 13g Fermase 36 7g Piperonyl butoxide 1g N,N-dimethylacetamide q.s. 100 g

[0108] Formulation Example 21 : 0.9% Compound A · esbiothrin hot fogging concentrate

[0109] Compound A 0.8g Fenobucarb 0.1g N,N-dimethylacetamide 12g Diesel oil q.s. 100 g

[0110] Formulation Example 22: 22% Compound A · esbiothrin suspoemulsion

[0111] Compound A 20g Fenobucarb 2g Isopropyl palmitate 18g Calcium dodecylbenzenesulfonate 2g Castor oil polyoxyethylene ether 0.5g Oxirane-propylene oxide block copolymer 1g Glycerol fatty acid ester polyoxyethylene ether 3g Alkyl sulfate 5g Isopropyl myristate 8g Xanthan gum 0.25g White carbon black 1.5g Potassium sorbate 0.4g Sodium benzoate 0.2g Glycerol 5g Water q.s. 100 g

[0112] Formulation Example 23: 10.5% Compound A · transfluthrin emulsifiable concentrate

[0113]

[0114] Formulation Example 24: 5% Compound A · transfluthrin aqueous emulsion

[0115] Compound A 4.5g D-Trans-chloropropene 0.5g N,N-dimethylcaproamide 10g Diisopropyl adipate 8g Alkylphenol polyoxyethylene ether phosphate 3g Oxirane-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 5g Castor oil polyoxyethylene 5g Ethylene glycol 3g Silicone compound 0.3g Water q.s. 100 g

[0116] Formulation Example 25: 7% Compound A · transfluthrin microemulsion

[0117] Compound A 6g D-trans-chloropropene chrysanthemate 1g Calcium dodecylbenzenesulfonate 6g Castor oil polyoxyethylene 20g Ethylene oxide-propylene oxide block copolymer 2g N,N-dimethylacetamide 20g Water q.s. 100 g

[0118] Formulation Example 26: 8% Compound A · transfluthrin soluble liquid

[0119] Compound A 6g D-trans-chloropropene chrysanthemate 2g Calcium dodecylbenzenesulfonate 5g Castor oil polyoxyethylene 4g Phenyl phenol polyoxyethylene ether phosphate 10g Piperonyl butoxide 5g N,N-dimethylpropionamide q.s. 100 g

[0120] Formulation Example 27: 2% Compound A · transfluthrin hot fogging concentrate

[0121] Compound A 1g D-trans-chloropropene chrysanthemate 1g Diisopropyl adipate 11g White oil q.s. 100 g

[0122] Formulation Example 28: 0.6% Compound A · esbiothrin aerosol

[0123]

[0124] Formulation Example 29: 27% Compound A · esbiothrin emulsifiable concentrate

[0125] Compound A 25.5g D-trans-chloropropene chrysanthemate 1.5g Diisopropyl adipate 12g Calcium dodecylbenzenesulfonate 5g Castor oil polyoxyethylene 2.5g Ethylene oxide-propylene oxide block copolymer 1.5g Lignosulfonate 5g Sodium dodecyl sulfate 2.5g Diisopropyl adipate 10g Xanthan gum 0.25g White carbon black 1g Potassium sorbate 0.5g Propylene glycol 6g Polydimethylsiloxane 0.2g Water q.s. 100 g

[0126] Formulation Example 30: 10% Compound A · fenoxycarb EC

[0127] Compound A 9g D-trans-chrysanthemum phenyl ether 1g Ningru 36 3g Fatty alcohol polyoxyethylene ether 5g Castor oil polyoxyethylene 2g Mesitylene 8g Tetramethylbenzene 5g Dodecylbenzene q.s. 100 g

[0128] Formulation Example 31 : 6% Compound A · fenoxycarb EW

[0129]

[0130] Formulation Example 32: 7% Compound A · fenoxycarb ME

[0131] Compound A 5g D-trans-chrysanthemum phenyl ether 2g Ethylene oxide-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 6g Castor oil polyoxyethylene 12g Fatty alcohol polyoxyethylene ether 3g N,N-dimethylacetamide 15g Water q.s. 100 g

[0132] Formulation Example 33: 10% Compound A · fenoxycarb SL

[0133] Compound A 5g D-trans-chrysanthemum phenyl ether 5g Sorbitan monostearate 2g Alkyl phenol polyoxyethylene ether 5g Phenyl phenol polyoxyethylene ether phosphate 11g Cyclohexanone 10g N,N-dimethylacetamide q.s. 100 g

[0134] Formulation Example 34: 6% Compound A · heptafluthrnrn EC

[0135] Compound A 5g Heptafluoromethyl ether chrysanthemum 1g Calcium dodecylbenzenesulfonate 54.5g Fatty alcohol polyoxyethylene ether 2g Castor oil polyoxyethylene 2.5g N-methyl pyrrolidone 12g N,N-dimethylpropionamide q.s. 100 g

[0136] Formulation Example 35: 5% Compound A · heptafluthrnrn EW

[0137] Compound A 4g Heptafluoromethyl ether chrysanthemum 1g N,N-dimethyl pivalamide 15g Alkyl phenol polyoxyethylene ether phosphate 2g Ethylene oxide-propylene oxide block copolymer 3g Calcium dodecylbenzenesulfonate 6g Ethylene glycol 5g Polydimethylsiloxane 0.3g Water q.s. 100 g

[0138] Formulation Example 36: 4.5% Compound A · heptafluthrnrn ME

[0139] Compound A 4g Heptafluoromethyl ether chrysanthemum 0.5g Ethylene oxide-propylene oxide block copolymer 1g Castor oil polyoxyethylene 13g Fatty alcohol polyoxyethylene ether 6g N,N-dimethylpropionamide 15g Water q.s. 100 g

[0140] Formulation Example 37: 6% Compound A · heptafluthrnrn SL

[0141] Compound A 3g Heptafluoromethyl ether chrysanthemum 3g Sorbitan monostearate 3g Alkyl phenol polyoxyethylene ether 6g Benzyl dimethyl phenol polyoxyethylene ether 12g Cyclohexanone 7g N,N-dimethylacetamide q.s. 100 g

[0142] Formulation Example 38: 0.3% Compound A · heptafluthrnrn aerosol

[0143] Compound A 0.2g Methoxybenzyl fluoro chrysanthemum 0.1g Isopropyl myristate 5g D100 q.s. 50 g Propane gas 50g

[0144] Formulation Example 39: 11% Compound A · d-Heptyl fluoride pyrethrin emulsifiable concentrate

[0145] Compound A 10g D-trans-heptafluoromethyl ether chrysanthemum 1g Calcium dodecylbenzenesulfonate 6g Fatty alcohol polyoxyethylene ether 1g Castor oil polyoxyethylene 5g Cyclohexanone 15g Mesitylene q.s. 100 g

[0146] Formulation Example 40: 6% Compound A · d-Heptyl fluoride pyrethrin aqueous emulsion

[0147]

[0148]

[0149] Formulation Example 41: 9% Compound A · d-Heptyl fluoride pyrethrin microemulsion

[0150] Compound A 8g D-trans-heptafluoromethyl ether chrysanthemum 1g Ethylene oxide-propylene oxide block copolymer 3g Castor oil polyoxyethylene 7g Fatty alcohol polyoxyethylene ether 9g N,N-dimethylpropionamide 17g Isopropyl myristate 3g Water q.s. 100 g

[0151] Formulation Example 42: 13% Compound A · d-Heptyl fluoride pyrethrin soluble concentrate

[0152] Compound A 11g D-trans-heptafluoromethyl ether chrysanthemum 2g Sorbitan monostearate 2g Calcium dodecylbenzenesulfonate 10g Fatty alcohol polyoxyethylene ether 5g Cyclohexanone 10g N,N-dimethylacetamide q.s. 100 g

[0153] Formulation Example 43: 6% Compound A · Bioallethrin / d-allethrin / esbiothrin emulsifiable concentrate

[0154]

[0155] Formulation Example 44: 7% Compound A · Bioallethrin / d-allethrin / esbiothrin aqueous emulsion

[0156]

[0157]

[0158] Formulation Example 45: 4.5% Compound A · Bioallethrin / d-allethrin / esbiothrin microemulsion

[0159]

[0160] Formulation Example 46: 8% Compound A · Bioallethrin / d-allethrin / esbiothrin soluble concentrate

[0161]

[0162] Formulation Example 47: 0.5% Compound A · Bioallethrin / d-allethrin / esbiothrin aerosol

[0163]

[0164] Formulation Example 48: 11% Compound A · cyphenothrin emulsifiable concentrate

[0165]

[0166]

[0167] Formulation Example 49: 5% Compound A · cyphenothrin aqueous emulsion

[0168] Compound A 4g Chloroalkyne 1g N-methyl pyrrolidone 12g Castor oil polyoxyethylene 6g Ethylene oxide-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 6g Isopropyl myristate 5g Glycerol 4g Polydimethylsiloxane 0.2g Water q.s. 100 g

[0169] Formulation Example 50: 3.5% Compound A · cyphenothrin microemulsion

[0170] Compound A 3g Chloroalkyne chrysanthemum 0.5g Ethylene oxide-propylene oxide block copolymer 2g Castor oil polyoxyethylene 3g Fatty alcohol polyoxyethylene ether 3g Phenyl phenol polyoxyethylene ether phosphate 12g N,n-dimethylpropionamide 20g Water q.s. 100 g

[0171] Formulation Example 51: 10% Compound A · cyphenothrin soluble liquid

[0172] Compound A 8g Alloxychlor 2g Styrenated phenol polyoxyethylene 4g Alkylphenol polyoxyethylene 4g Castor oil polyoxyethylene 12g Tributyl citrate 15g N,n-dimethylacetamide q.s. 100 g

[0173] Formulation Example 52: 1% Compound A · cyphenothrin aerosol

[0174] Compound A 0.8g Alloxychlor 0.2g Alloxychlor 12g Diisopropyl adipate Odorless kerosene q.s. 50 g 50g

[0175] Formulation Example 53: 13% Compound A · d-allethrin emulsifiable concentrate

[0176]

[0177] Formulation Example 54: 6% Compound A · d-allethrin aqueous emulsion

[0178] Propane gas 5g Compound A 1g Alloxychlor 10g Alloxychlor 8g Diisopropyl adipate 3g Calcium dodecylbenzenesulfonate 3g Ethylene oxide-propylene oxide block copolymer 4g Fatty alcohol polyoxyethylene 0.3g Glycerol Silicone compound

[0179] Formulation Example 55: 0.8% Compound A · d-allethrin aerosol

[0180] Water 0.6g q.s. 100 g 0.2g Compound A 5g Alloxychlor Alloxychlor Odorless kerosene 50g

[0181] Formulation Example 56: 9% Compound A · d-allethrin microemulsion

[0182] q.s. 50 g 8g Propane gas 1g Compound A 6g Alloxychlor 12g Alloxychlor 3g Castor oil polyoxyethylene 15g Fatty alcohol polyoxyethylene N,n-dimethylacetamide

[0183] Formulation Example 57: 10% Compound A · d-allethrin soluble liquid

[0184] Water 8g q.s. 100 g 2g Compound A 7g Alloxychlor 5g Alloxychlor 3g Alkylphenol polyoxyethylene 12g Ethylene oxide-propylene oxide block copolymer Tributyl acetyl citrate

[0185] Formulation Example 58: 1.5% Compound A · d-allethrin thermal fogging concentrate

[0186] N,n-dimethylacetamide 1g q.s. 100 g 0.5g Compound A 8g Alloxychlor 20g Alloxychlor Ethylene glycol methyl ether

[0187] Formulation Example 59: 11% Compound A·esbiothrin suspoemulsion

[0188] White oil 9.5g Diesel oil 1.5g q.s. 100 g 10g Compound A 5g Alloxychlor 7g Isopropyl myristate 0.5g Calcium dodecylbenzenesulfonate 6g Castor oil polyoxyethylene 4g Ethylene oxide-propylene oxide block copolymer 0.5g Alkylphenol polyoxyethylene formaldehyde condensate sulfate 0.3g Alkylsulfonate 1.0g Alkylphenol polyoxyethylene formaldehyde condensate sulfate 0.5g Xanthan gum 5g Magnesium aluminum silicate Potassium sorbate

[0189] Formulation Example 60: 6% Compound A·esbiothrin emulsifiable concentrate

[0190] Ethylene glycol 5g Water 1g q.s. 100 g 5g Compound A 1g Alloxychlor 6g Alloxychlor 20g Benzyl dimethylphenol polyoxyethylene ether Castor oil polyoxyethylene

[0191] Formulation Example 61: 5% Compound A·esbiothrin water emulsion

[0192]

[0193] Formulation Example 62: 0.6% Compound A·esbiothrin aerosol

[0194] Cyclohexanone 0.3g Mesitylene 0.3g q.s. 100 g 4g D110 Compound A Alloxychlor 50g

[0195] Formulation Example 63: 5.5% Compound A·esbiothrin microemulsion

[0196] Alloxychlor 5g q.s. 50 g 0.5g Propane gas 10g Compound A 6g Alloxychlor 5g Alloxychlor 20g Castor oil polyoxyethylene Fatty alcohol polyoxyethylene

[0197] Formulation Example 64: 8% Compound A·esbiothrin soluble liquid

[0198] N,n-dimethylpropionamide 7g Water 1g q.s. 100 g 6g Compound A 6g Alloxychlor 2g Alloxychlor 10g Alkylphenol polyoxyethylene Sorbitan fatty acid ester polyoxyethylene ether

[0199] Formulation Example 65: 1.5% Compound A·esbiothrin hot fogging concentrate

[0200] Isopropyl palmitate 2g N,n-dimethylacetamide 0.5g q.s. 100 g 10g Compound A Alloxychlor Alloxychlor White oil q.s. 100 g

[0201] Formulation Example 66: 11% Compound A·esbiothrin suspoemulsion

[0202]

[0203] Insecticidal efficacy test of each of the above formulation examples against mosquitoes and flies

[0204] Test target: female adults of Culex pipiens pallens (local resistant strain in Yangzhou) aged 3-5 days after eclosion without blood-feeding;

[0205] Musca domestica (local resistant strain in Yangzhou), adults aged 3-4 days after eclosion, half of them being female and the other half being male;

[0206] Test method: according to GB / T 13917.10-2009, the test was carried out by using simulated room hanging cage method in simulated field.

[0207] Method of application: ultra-low volume spraying

[0208] Dose setting: the spray concentration of the active ingredient of the preparation examples is 1.5 mg / m 3 ;

[0209] Control sample 1: 5% compound A EC, spray dose 1.5 mg / m 3 ;

[0210] Control sample 2: 5% tetraflumuron EC, spray dose 1.5 mg / m 3 ;

[0211] Control sample 3: 5% methoxyfenozide EC, spray dose 1.5 mg / m 3 ;

[0212] Control sample 4: 5% transfluthrin EC, spray dose 1.5 mg / m 3 ;

[0213] Control sample 5: 10.4% bioresmethrin·allethrin EW (Jiangsu Gongcheng Biological Technology Co., Ltd.), spray dose 1.5 mg / m 3 ; Control sample 6: 5% bioresmethrin·tetraflumuron EW (Jiangsu Youjia Plant Protection Co., Ltd.), spray dose 1.5 mg / m 3 ;

[0214] Test results:

[0215] The knockdown effect of the single dose EC of control sample 1 on mosquitoes and flies is obviously poorer than that of each preparation example of the application; the knockdown effect of 5% tetraflumuron EC of control sample 2, 5% methoxyfenozide EC of control sample 3 and 5% transfluthrin EC of control sample 4 on mosquitoes and flies is very good, but the killing effect is not good and the mortality rate is low; the preparation example 3, 18 and 24 of the application not only have good knockdown effect, but also have high mortality rate (see Tables 5, 6 and 7).

[0216] Table 5: efficacy test of preparation example 3 on Culex pipiens pallens and Musca domestica

[0217]

[0218] Table 6: efficacy test of preparation example 18 on Culex pipiens pallens and Musca domestica

[0219]

[0220] Table 7: efficacy test of preparation example 24 on Culex pipiens pallens and Musca domestica

[0221]

[0222] Table 8 Formulation examples for efficacy test against Culex pipiens pallens and Musca domestica

[0223]

[0224]

[0225] The test results (see Table 8) show that the formulation examples described in Table 8 are superior to the commercially available control sample 5 (10.4% cypermethrin·allethrin EW) in knockdown effect against Culex pipiens pallens and Musca domestica, and some of the formulation examples are superior to the commercially available control sample 6 (5% cypermethrin·tetramethrin EW) in knockdown effect, and the 24 h mortality rates of the formulation examples of the present application are all above 90%, wherein the mortality rates of the formulation examples 7-10, 23, 26, 34, 39-40, 43 and 48 all reach 100% (see Table 8), thus it can be seen that the formulation examples all achieve the efficacy of the mainstream health insecticides on the market, and the efficacy of some of the examples is obviously superior to the controls.

[0226] The above examples are only for illustrating the technical concept and technical features of the present application, and cannot limit the protection scope of the present application. Any equivalent transformation or modification according to the essence of the present application should be covered within the protection scope of the present application.

Claims

1. A sanitary insecticide composition containing methoxyacrylate compounds, characterized in that, The composition consists of component A and component B, where component A is a methoxyacrylate compound with the following structural formula, and component B is any one of tetrafluoroethylene, methoxybenzylfluoroethylene, and sevomethoxyethylene. The mass ratio of component A to component B is 20:1 to 1:

1.

2. A sanitary insecticide, characterized in that: The formulation uses the composition of claim 1 as the effective active ingredient, which accounts for 0.1% to 30% of the formulation mass.

3. The sanitary insecticide preparation according to claim 2, characterized in that: The formulation also contains excipients, which are any one or more of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, and water.

4. The sanitary insecticide according to claim 2, characterized in that: The formulation is in the form of an aerosol, emulsifiable concentrate, water emulsion, microemulsion, soluble liquid, thermal aerosol, or suspension.

5. The use of the composition of claim 1 or the formulation of claim 3, characterized in that: The use of the composition of claim 1 or the formulation of claim 3 in the control of sanitary pests.

6. The application according to claim 5, characterized in that: The sanitary pests mentioned are one or more of the following: Culex pipiens pallens, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassing, midge, housefly, house fly, golden maggot, green leaf fly, copper green fly, bright green fly, summer toilet fly, and tussock fly.

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