Minimally invasive vitreous body specimen sampler

Abstract

The invention provides a minimally invasive vitreous body specimen sampler, and relates to the technical field of medical instruments, the minimally invasive vitreous body specimen sampler comprises a control part, the lower end of the control part is connected with a puncture needle, and the control part is internally provided with a detachable collection tube; the puncture needle is provided with a needle body on the outer side and an inner core which is inserted into the needle body and rotates in the needle body; a suction hole is formed in the tip end of the needle body, and cutting bodies arranged along the circumference of the inner core are arranged at the position, aligned with the suction hole, of the inner core. A sealing gasket connected with the pull rod is arranged in a pipe body of the collecting pipe, and the sealing gasket is connected with the pipe body in a sealing manner; a connecting body is arranged at the lower end of the pipe body, and the pipe body is rotationally connected and communicated with the inner core through the connecting body; a linkage structure is arranged in the control part and is connected with the pull rod and the inner core, so that the pull rod drives the inner core to rotate when linearly moving along the tube body, and through the structure, the clinical diagnosis and treatment requirements can be met, and the vitreous body can be sampled in a minimum-trauma and most efficient and safe manner.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to a minimally invasive vitreous specimen sampler. Background Art

[0002] The internal tissues of the eyeball have established a unique immune microenvironment that is different from other tissues and organs through the blood-eye barrier. Intraocular fluid testing can directly reflect a variety of information about the intraocular microenvironment, and is of great value for the diagnosis and differential diagnosis of a variety of infectious and neoplastic diseases. Some of the detection indicators can also be used for disease follow-up, real-time quantitative reflection of disease changes, and can be used for prognosis judgment. With the development of high-throughput and micro-sample detection technology, 50μl intraocular fluid samples can be used for multiple tests such as nucleic acid, cytokine, antigen and antibody at the same time, greatly improving the clinical value of intraocular fluid testing.

[0003] The vitreous is the best specimen for posterior segment diseases, but unlike the collection of aqueous humor, the acquisition of vitreous specimens is relatively complicated and risky. The vitreous is viscous and is composed of a transparent collagen fiber scaffold containing hyaluronic acid and water. The viscous fibrin cannot be directly aspirated by an injection needle, but can be cut by scissors. In addition, improper traction on the vitreous can easily cause tears and holes in the retina.

[0004] At present, the collection of vitreous specimens includes two methods: syringe puncture and extraction, and collection by vitrectomy. However, syringe collection is only for the elderly with highly liquefied vitreous, and the needle tip must be located exactly in the "water bag" in the vitreous to extract the liquid. Repeated positioning and extraction are required, increasing the risk of retinal tears, bleeding, and detachment. The vitrectomy method, due to its high-speed cutting head, can avoid vitreous traction, but it requires the establishment of three incision channels in the eyeball, while meeting the requirements of intraocular perfusion and lighting to complete subtotal and total vitrectomy. In addition, due to the inflow and suction of the perfusion fluid, the specimens absorbed by the cutting head contain a large amount of perfusion fluid. This method is cumbersome and extremely costly, and the risk of trauma and complications to the patient's eyeball also rises sharply.

[0005] Therefore, for eyes that do not require vitrectomy surgery, there is an urgent need for a minimally invasive vitreous sampler that can meet clinical diagnosis and treatment needs and sample the vitreous in the least traumatic, most efficient and safe way. Summary of the invention

[0006] The present invention provides a minimally invasive vitreous specimen sampler, which specifically comprises:

[0007] A control unit, wherein the lower end of the control unit is connected to the puncture needle, and a detachable collection tube is installed inside the control unit; the puncture needle has an outer needle body and an inner core inserted into the needle body and rotating in the needle body; a suction hole is provided at the tip of the needle body, and a cutting body arranged along the circumference of the inner core is provided at a height where the inner core is aligned with the suction hole; a sealing gasket connected to the pull rod is provided inside the tube body of the collection tube, and the sealing gasket is sealed and connected to the tube body; a connecting body is provided at the lower end of the tube body, and the tube body and the inner core are rotationally connected and communicated through the connecting body; a linkage structure is provided inside the control unit, and the linkage structure connects the pull rod and the inner core, so that when the pull rod moves linearly along the tube body, the inner core is driven to rotate.

[0008] Preferably, the linkage structure includes a rotating rod, a first gear, a control slider and a second gear; the second gear is rotatably connected inside the main body of the control part; after the puncture needle is connected to the control part, the inner core is connected to the center hole of the second gear and is driven to rotate by the second gear; the rotating rod is rotatably connected inside the main body; the middle part of the rotating rod is a threaded section, and the first gear is fixedly connected to the outside of one end of the rotating rod close to the second gear; the first gear and the second gear are meshed with each other; a threaded hole of the same shape as the threaded section is opened inside the control slider, and the control slider is sleeved on the outside of the threaded section, and the control slider slides linearly along the central axis of the rotating rod.

[0009] Preferably, a needle seat is provided at one end of the needle body close to the control part; a first mounting column is provided at one end of the main body of the control part close to the needle body; the needle seat is sleeved on the outside of the first mounting column, and the inner core passes through the first mounting column and is inserted into the main body.

[0010] Preferably, a connector is provided at one end of the tube body close to the puncture needle, and the connector is rotatably connected to a rotating body at one end toward the puncture needle; the connector and the rotating body are sealedly connected; the rotating body is fixedly connected to the inner core, and the rotating body and the inner core are sealedly connected.

[0011] Preferably, the upper end of the control slider is rotatably connected to a connecting handle, and a screw hole is provided at one end of the connecting handle close to the collection tube; a threaded rod is provided at one end of the pull rod close to the connecting handle, and the threaded rod of the pull rod is inserted into the screw hole of the connecting handle.

[0012] Preferably, a non-circular hole is opened in the center of the second gear, and the cross-sectional shape of the connecting end of the inner core is the same as the hole shape of the second gear, and when the puncture needle is connected to the control unit, the connecting end of the inner core is inserted into the hole of the second gear.

[0013] Preferably, the width of the cutting body is smaller than the diameter of the suction hole, and there is at least one cutting body.

[0014] Preferably, a ball bearing is arranged between the threaded hole of the control slider and the contact surface of the threaded section.

[0015] Preferably, a contact pad is provided inside the main body of the control unit, and an elastic member is provided at the upper end of the main body; when the collection tube is installed inside the control unit, the elastic member abuts against the collection tube.

[0016] Preferably, the connector and the rotating body are connected via a bearing.

[0017] Beneficial Effects

[0018] In the present invention, the puncture needle is vertically inserted 5mm into the scleral surface 3.5-4mm from the patient's corneal scleral edge, and the pull rod is pulled to drive the sealing gasket to slide along the tube body, so that negative pressure is generated inside the collection tube, and the vitreous is sucked in through the suction hole of the needle body. At the same time, driven by the linkage structure, the inner core rotates, driving the cutting body to rotate, and the fibrin in the vitreous sample entering the suction hole is cut off. The vitreous sample is sucked into the collection tube for storage. Through this device, for the affected eye that does not need resection surgery, it can meet the clinical diagnosis and treatment needs, and the vitreous can be sampled in the least traumatic, most efficient and safe way. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solution of the embodiment of the present invention, the drawings of the embodiment are briefly introduced below.

[0020] The drawings described below are only related to some embodiments of the present invention, but are not intended to limit the present invention.

[0021] In the attached picture:

[0022] Figure 1 A schematic diagram of the three-dimensional structure of a vitreous specimen sampler according to an embodiment of the present invention is shown.

[0023] Figure 2 An exploded view of a vitreous specimen sampler according to an embodiment of the present invention is shown.

[0024] Figure 3 A cross-sectional view of a puncture needle of a vitreous specimen sampling device according to an embodiment of the present invention is shown.

[0025] Figure 4 The vitreous specimen sampling device according to the embodiment of the present invention is shown. Figure 3 A local enlarged schematic diagram of point A is shown.

[0026] Figure 5 A cross-sectional view showing a control portion of a vitreous specimen sampler according to an embodiment of the present invention.

[0027] Figure 6The vitreous specimen sampling device according to the embodiment of the present invention is shown. Figure 5 A local enlarged schematic diagram of point B is shown.

[0028] Figure 7 The vitreous specimen sampling device according to the embodiment of the present invention is shown. Figure 5 A local enlarged schematic diagram of point C is shown.

[0029] Figure 8 A cross-sectional view of a collection tube of a vitreous specimen sampler according to an embodiment of the present invention is shown.

[0030] Fig. 9 The vitreous specimen sampling device according to the embodiment of the present invention is shown. Figure 8 A local enlarged schematic diagram of point D is shown.

[0031] Fig.10 A connection diagram of a collection tube and a puncture needle of a vitreous specimen sampler according to an embodiment of the present invention is shown.

[0032] Fig.11 The vitreous specimen sampling device according to the embodiment of the present invention is shown. Fig.10 A local enlarged schematic diagram of point E is shown.

[0033] Fig.12 The vitreous specimen sampling device according to the embodiment of the present invention is shown. Fig.10 A local enlarged schematic diagram of point F is shown.

[0034] Fig.13 The figure shows an assembly diagram of a collection tube of a vitreous specimen sampler according to an embodiment of the present invention.

[0035] Fig.14 A schematic diagram of the three-dimensional structure of the control part of the vitreous specimen sampler according to an embodiment of the present invention is shown in another direction.

[0036] List of main reference symbols

[0037] 1. puncture needle; 101. needle body; 1011. suction hole; 102. needle seat; 103. inner core; 1031. cutting body; 1032. guide body; 1033. connection end;

[0038] 2. Control unit; 201. Main body; 2011. First mounting column; 2012. Second mounting column; 202. Rotating rod; 2021. First gear; 2022. Threaded section; 203. Control slider; 204. Second gear; 205. Connecting handle; 206. Elastic member; 207. Contact pad;

[0039] 3. Collection tube; 301. Tube body; 3011. Connector; 3012. Bearing; 3013. Rotating body; 302. Pull rod; 3021. Sealing gasket. DETAILED DESCRIPTION

[0040] In order to make the purpose, scheme and advantages of the technical solution of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described below in conjunction with the drawings of specific embodiments of the present invention.

[0041] Example: Please refer to Figures 1 to 14 :

[0042] like Figure 1 , Figure 2 and Figure 4 As shown, the present invention proposes a minimally invasive vitreous specimen sampler, comprising:

[0043] The control part 2 is provided with a puncture needle 1 at the lower end thereof, and a detachable collection tube 3 is installed inside the control part 2; the puncture needle 1 has an outer needle body 101 and an inner core 103 inserted into the needle body 101 and rotating inside the needle body 101; a suction hole 1011 is provided at the tip of the needle body 101, and a cutting body 1031 arranged along the circumference of the inner core 103 is provided at a height where the inner core 103 is aligned with the suction hole 1011; a sealing gasket 3021 connected to the pull rod 302 is provided inside the tube body 301 of the collection tube 3, and the sealing gasket 3021 is sealed and connected to the tube body 301; a connecting body 3011 is provided at the lower end of the tube body 301, and the tube body 301 is rotatably connected and communicated with the inner core 103 through the connecting body 3011; a linkage structure is provided inside the control part 2, and the linkage structure connects the pull rod 302 and the inner core 103, so that when the pull rod 302 moves linearly along the tube body 301, the inner core 103 is driven to rotate.

[0044] Among them, Figure 5 , Figure 6 and Figure 7As shown, the linkage structure includes a rotating rod 202, a first gear 2021, a control slider 203 and a second gear 204; the second gear 204 is rotatably connected inside the main body 201 of the control unit 2; after the puncture needle 1 is connected to the control unit 2, the inner core 103 is connected to the center hole of the second gear 204 and is driven to rotate by the second gear 204; the rotating rod 202 is rotatably connected inside the main body 201; the middle part of the rotating rod 202 is a threaded section 2022, and the outer side of the end of the rotating rod 202 close to the second gear 204 is fixedly connected to the first gear 2021; the first gear 2021 and the second gear 204 are meshed with each other; a threaded hole of the same shape as the threaded section 2022 is opened inside the control slider 203, and the control slider 203 is sleeved on the outer side of the threaded section 2022, and the control slider 203 is along the central axis of the rotating rod 202 Linear sliding; when the control slider 203 slides linearly along the central axis of the rotating rod 202, the cooperation between the control slider 203 and the threaded section 2022 will cause the rotating rod 202 to rotate inside the main body 201 and drive the first gear 2021 to rotate; the first gear 2021 is engaged with the second gear 204, driving the second gear 204 to rotate while driving the inner core 103 to rotate inside the needle body 101, so as to use the cutting body 1031 of the inner core 103 to achieve the cutting of fibrin in the vitreous sample; specifically, the transmission ratio between the two gears can be adjusted by the number of teeth of the first gear 2021 and the second gear 204. The preferred solution is that the number of teeth of the second gear 204 is slightly larger than that of the first gear 2021, so that the second gear 204 is decelerated relative to the first gear 2021, thereby improving the safety when cutting the vitreous sample.

[0045] Among them, Figure 3 , Figure 5 and Fig.10 As shown, a needle seat 102 is provided at one end of the needle body 101 close to the control unit 2; a first mounting column 2011 is provided at one end of the main body 201 of the control unit 2 close to the needle body 101; the needle seat 102 is sleeved on the outside of the first mounting column 2011, and the inner core 103 passes through the first mounting column 2011 and is inserted into the main body 201; the overall design of the puncture needle 1 is detachable, and with the detachable design of the collection tube 3, the consumables in the device are only the puncture needle 1 and the collection tube 3, which effectively reduces the medical cost.

[0046] Among them, Figure 8 , Fig. 9 , Fig.10 and Fig.11As shown, a connector 3011 is provided at one end of the tube body 301 close to the puncture needle 1, and a rotating body 3013 is rotatably connected to the end of the connector 3011 facing the puncture needle 1; the connector 3011 and the rotating body 3013 are sealedly connected; the rotating body 3013 is fixedly connected to the inner core 103, and the rotating body 3013 is sealedly connected to the inner core 103; when the inner core 103 is driven to rotate by the second gear 204, the stability and sealing of the connection between the inner core 103 and the collection tube 3 are maintained by the rotating body 3013 to prevent the sample in the inner core 103 from being exposed; at the same time, through the above structure, the puncture needle 1 and the collection tube 3 are designed to be detachable. In one embodiment, a guide chamfer is provided at the entrance of all pipelines that the inner core 103 needs to pass through, so that the outer diameter of the chamfer is larger than the outer diameter of the inner core 103, so that when the inner core 103 is inserted into any pipeline, it can be accurately aligned with the pipeline entrance under the guidance of the chamfered inclined surface.

[0047] Among them, Figure 5 , Figure 8 and Fig.13 As shown, the upper end of the control slider 203 is rotatably connected to the connecting handle 205, and the end of the connecting handle 205 close to the collection tube 3 is provided with a screw hole; the end of the pull rod 302 close to the connecting handle 205 is provided with a threaded rod, and the threaded rod of the pull rod 302 is inserted into the screw hole of the connecting handle 205; after the connecting handle 205 is connected to the pull rod 302, while pulling the connecting handle 205 drives the pull rod 302 to generate negative pressure in the collection tube 3, it drives the control slider 203 to move linearly, and then drives the inner core 103 to rotate synchronously through the linkage structure, so as to realize the simultaneous suction and cutting of the vitreous sample.

[0048] Among them, Figure 3 , Figure 6 , Fig.10 and Fig.12 As shown, a non-circular hole is opened in the center of the second gear 204, and the cross-sectional shape of the connecting end 1033 of the inner core 103 is the same as the hole shape of the second gear 204, and when the puncture needle 1 is connected to the control unit 2, the connecting end 1033 of the inner core 103 is inserted into the hole of the second gear 204; in one embodiment, in order to facilitate the alignment and insertion of the inner core 103 and the center hole of the second gear 204, the connecting end 1033 of the inner core 103 can adopt a tapered tube to achieve an interference connection between the inner core 103 and the second gear 204.

[0049] Among them, Figure 4As shown, the width of the cutting body 1031 is smaller than the diameter of the suction hole 1011, and there is at least one cutting body 1031; the cutting body 1031 will not block the suction hole 1011 and different numbers of cutting bodies 1031 can adjust the cutting speed, and the basic cutting frequency of the inner core 103---when the number of cutting bodies 1031 is one---depends on the pitch of the threaded segment 2022 of the rotating rod 202 and the transmission ratio of the first gear 2021 and the second gear 204. The final cutting frequency of the inner core 103 is the basic cutting frequency multiplied by the number of cutting bodies 1031. Since the diameters of the collection tubes 3 of different capacities are different, the number of vitreous samples sucked in at the same time is different, and the puncture needle 1 with a suitable cutting frequency can be selected according to the suction volume.

[0050] In one embodiment, a ball bearing is arranged between the threaded hole of the control slider 203 and the contact surface of the threaded segment 2022; the ball bearing can effectively reduce the friction between the control slider 203 and the threaded segment 2022 of the rotating rod 202, thereby making the linkage between the pull rod 302 and the second gear 204 smoother.

[0051] Among them, Fig.13 and Fig.14 As shown, a contact pad 207 is provided inside the main body 201 of the control unit 2, and an elastic member 206 is provided at the upper end inside the main body 201; when the collection tube 3 is installed inside the control unit 2, the elastic member 206 abuts against the collection tube 3; the contact pad 207 supports the collection tube 3 and fixes the collection tube 3 inside the control unit 2 through the elastic member 206 to prevent the collection tube 3 from moving when the pull rod 302 is pulled.

[0052] Among them, Figure 8 and Fig. 9 As shown, the connector 3011 and the rotating body 3013 are connected via a bearing 3012 , which ensures the smooth rotation of the rotating body 3013 and further ensures the stability of the collection tube 3 when sucking the vitreous sample under negative pressure.

[0053] Among them, Figure 4 As shown, a guide body 1032 is provided at one end of the inner core 103 near the suction hole 1011. The cross-section of the guide body 1032 is triangular. When the vitreous sample is sucked into the inner core 103, the fibrin is limited by the guide body 1032 and tilted, forming a certain angle with the cutting body 1031, and directing the flow direction of the vitreous sample to the center of the inner core 103, thereby preventing the vitreous sample from being cut and broken again by the cutting body 1031 opposite to the suction hole 1011, thereby ensuring the quality of the vitreous sample.

[0054] Specific usage and function of this embodiment: When the present invention is used, the puncture needle 1 is vertically inserted 5mm into the 3.5-4mm scleral surface of the patient's corneal sclera edge, and the pull rod 302 is pulled to drive the sealing gasket 3021 to slide along the tube body 301, so that negative pressure is generated inside the collection tube 3, and the vitreous body is sucked in through the suction hole 1011 of the needle body 101. At the same time, driven by the linkage structure, the inner core 103 rotates, driving the cutting body 1031 to rotate, and the fibrin in the vitreous sample entering the suction hole 1011 is cut off. The vitreous sample is sucked into the collection tube 3 for storage. Through this device, for the affected eye that does not need resection surgery, it can meet the clinical diagnosis and treatment needs, and the vitreous body can be sampled in the least traumatic, most efficient and safe way.

[0055] The above description is merely an exemplary embodiment of the present invention and is not intended to limit the protection scope of the present invention. The protection scope of the present invention is determined by the appended claims.

Claims

1. A minimally invasive vitreous specimen sampler, characterized in that: include: A control unit (2), wherein the lower end of the control unit (2) is connected to the puncture needle (1), and a detachable collection tube (3) is installed inside the control unit (2); The puncture needle (1) comprises an outer needle body (101) and an inner core (103) inserted into the needle body (101) and rotating on the needle body (101); a suction hole (1011) is provided at the tip of the needle body (101), and cutting bodies (1031) arranged along the circumference of the inner core (103) are provided at a height where the inner core (103) is aligned with the suction hole (1011); A sealing gasket (3021) connected to the pull rod (302) is provided inside the tube body (301) of the collection tube (3), and the sealing gasket (3021) is sealed and connected to the tube body (301); a connector (3011) is provided at the lower end of the tube body (301), and the tube body (301) and the inner core (103) are rotatably connected and communicated through the connector (3011); A linkage structure is provided inside the control part (2), and the linkage structure connects the pull rod (302) and the inner core (103), so that when the pull rod (302) moves linearly along the tube body (301), the inner core (103) is driven to rotate.

2. A minimally invasive vitreous specimen sampler according to claim 1, characterized in that: The linkage structure comprises a rotating rod (202), a first gear (2021), a control slider (203) and a second gear (204); the second gear (204) is rotatably connected inside the main body (201) of the control unit (2); after the puncture needle (1) is connected to the control unit (2), the inner core (103) is connected to the center hole of the second gear (204) and is driven to rotate by the second gear (204); the rotating rod (202) is rotatably connected inside the main body (201); the rotating rod (2 02) has a threaded section (2022) in the middle, and a first gear (2021) is fixedly connected to the outer side of one end of the rotating rod (202) close to the second gear (204); the first gear (2021) and the second gear (204) are meshed with each other; a threaded hole having the same shape as the threaded section (2022) is provided inside the control slider (203), and the control slider (203) is sleeved on the outer side of the threaded section (2022), and the control slider (203) slides linearly along the central axis of the rotating rod (202).

3. The minimally invasive vitreous specimen sampler according to claim 1, characterized in that: A needle seat (102) is provided at one end of the needle body (101) close to the control unit (2); a first mounting column (2011) is provided at one end of the main body (201) of the control unit (2) close to the needle body (101); the needle seat (102) is sleeved on the outside of the first mounting column (2011), and the inner core (103) passes through the first mounting column (2011) and is inserted into the main body (201).

4. The minimally invasive vitreous specimen sampler according to claim 1, characterized in that: A connector (3011) is provided at one end of the tube body (301) close to the puncture needle (1), and the connector (3011) is rotatably connected to a rotating body (3013) at one end facing the puncture needle (1); the connector (3011) and the rotating body (3013) are sealedly connected; the rotating body (3013) and the inner core (103) are fixedly connected, and the rotating body (3013) and the inner core (103) are sealedly connected.

5. The minimally invasive vitreous specimen sampler according to claim 2, characterized in that: The upper end of the control slider (203) is rotatably connected to a connecting handle (205), and a screw hole is provided at one end of the connecting handle (205) close to the collection tube (3); a threaded rod is provided at one end of the pull rod (302) close to the connecting handle (205), and the threaded rod of the pull rod (302) is inserted into the screw hole of the connecting handle (205).

6. The minimally invasive vitreous specimen sampler according to claim 2, characterized in that: A non-circular hole is provided at the center of the second gear (204), and the cross-sectional shape of the connecting end (1033) of the inner core (103) is the same as the hole shape of the second gear (204), and when the puncture needle (1) is connected to the control unit (2), the connecting end (1033) of the inner core (103) is inserted into the hole of the second gear (204).

7. The minimally invasive vitreous specimen sampler according to claim 1, characterized in that: The width of the cutting body (1031) is smaller than the diameter of the suction hole (1011), and there is at least one cutting body (1031).

8. The minimally invasive vitreous specimen sampler according to claim 2, characterized in that: A ball bearing is arranged between the threaded hole of the control slider (203) and the contact surface of the threaded section (2022).

9. The minimally invasive vitreous specimen sampler according to claim 1, characterized in that: A contact pad (207) is provided inside the main body (201) of the control unit (2), and an elastic member (206) is provided at the upper end inside the main body (201); when the collection tube (3) is installed inside the control unit (2), the elastic member (206) abuts against the collection tube (3).

10. The minimally invasive vitreous specimen sampler according to claim 4, characterized in that: The connecting body (3011) and the rotating body (3013) are connected via a bearing (3012).

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