Nerve soothing tea as well as preparation method and application thereof

By using suffocation tea prepared with medicinal materials such as jujube seeds, lotus seeds, lilies, etc., the problems of unsatisfactory effects and low bioavailability of existing suffocation compositions have been solved, and significant suffocation and sleep aid effects have been achieved, reducing side effects.

CN119679894APending Publication Date: 2025-03-25CHONGQING YONGCHUAN DISTRICT HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202411674195.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-21
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

In the prior art, the Anshen composition has poor effect, low bioavailability and high toxicity, making it difficult to effectively solve the insomnia problem caused by social pressure and fast life rhythm in modern people.

Method used

A formula of Anshen tea is adopted, including jujube seeds, lotus seeds, lily, citron, Gastrodia elata, Angelica sinensis and licorice. By strictly selecting authentic medicinal materials, optimizing drying conditions and mixing and mixing, the bioavailability of medicinal materials is improved.

Benefits of technology

It has achieved significant enhancement of the calming effect, improved sleep quality, reduced side effects, improved medicinal efficacy and the efficacy of health products, and is suitable for alleviating insomnia.

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses nerve soothing tea and a preparation method and application thereof.The nerve soothing tea is prepared from, by mass, 10-20 parts of spina date seeds, 10-20 parts of lotus seeds, 10-20 parts of lilies, 10-20 parts of citron, 3-6 parts of gastrodia elata, 5 parts of angelica sinensis and 6 parts of liquorice. The preparation process comprises the following steps: step 1, material selection and preparation: genuine medicinal materials of spina date seed, lotus seed, lily, citron, gastrodia elata, angelica sinensis and liquorice are selected; step 2, cleaning and drying; and step 3, mixing and blending: mixing and blending the dried medicinal materials in proportion. According to the invention, the compatibility of monarch, minister, assistant and guide is combined with the preparation technique of the technical scheme, so that the effective active ingredients of all the medicines can be extracted and utilized to the maximum extent, the efficacy of all the medicines and the efficacy of health care products are exerted to the maximum extent, the bioavailability is improved, and the dosage of raw medicinal materials is correspondingly reduced.
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Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to a tranquilizing tea and a preparation method and application thereof. Background Art

[0002] Insomnia is a disease characterized by the inability to get normal sleep, mainly manifested by insufficient sleep time and insufficient sleep depth. Mild cases are manifested by difficulty falling asleep, shallow sleep, waking up from time to time, or difficulty falling asleep again after waking up; severe cases are unable to fall asleep all night. The overall pathogenesis is the disharmony of yin and yang and the disharmony of qi and blood.

[0003] Research has found that the main site of insomnia is the heart, which is closely related to the liver and spleen. Traditional Chinese medicine believes that the heart is the organ that dominates mental activities, and "the heart governs the spirit". If the mind is peaceful, it is easy to fall asleep; on the contrary, if the mind is uneasy, it is difficult to fall asleep. The state of the mind is closely related to the nourishment of blood. The heart can only maintain normal physiological functions if it is fully nourished by blood. Blood comes from the fine substances after digestion and absorption of food, which are transformed into blood in the body. On the one hand, blood nourishes the heart and provides the heart with sufficient nutrients; on the other hand, blood is stored in the liver, making the liver soft; at the same time, the production and regulation of blood depends on the function of the spleen, which is responsible for converting nutrients in food into blood. Therefore, the normal function of the spleen directly affects the production and regulation of blood.

[0004] Modern people are facing increasing social and work pressures, and long-term irregular sleep is most likely to damage the liver. Anxiety and emotional frustration can easily lead to liver qi stagnation and liver failure to release. The liver meridian is in season at Chou time, and if people do not sleep soundly in bed, blood cannot return to the liver, which can easily lead to liver blood malnutrition in the long run; liver dysfunction leads to insomnia. Chronic insomnia patients have a long course of disease, which consumes qi and blood over time, and are often caused by deficiency of both heart and spleen. In addition, the fast pace of modern life and high pressure of life also lead to liver depression and spleen deficiency. Therefore, it is of great significance to develop a Chinese medicine tea substitute that can nourish the heart and calm the mind. Summary of the invention

[0005] The present invention aims to provide a tranquilizing tea and a preparation method and application thereof, so as to solve the problems of unsatisfactory tranquilizing effect, low bioavailability and high toxicity of the tranquilizing composition in the prior art.

[0006] To achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a kind of tranquilizing tea, comprising the following raw materials, by weight, 10-20 parts of Chinese jujube seeds, 10-20 parts of lotus seeds, 10-20 parts of lilies, 10-20 parts of citrons, 3-6 parts of gastrodia elata, 5 parts of angelica, and 6 parts of licorice.

[0007] Preferably, as an improvement, the weight proportions of the raw materials are 10 parts of spinach seeds, 10 parts of lotus seeds, 10 parts of lilies, 10 parts of citrons, 3-6 parts of gastrodia elata, 5 parts of angelica sinensis, and 6 parts of liquorice.

[0008] Preferably, as an improvement, the Chinese jujube kernels are fried Chinese jujube kernels.

[0009] Preferably, as an improvement, a tranquilizing tea is used in the preparation of tranquilizing medicines.

[0010] Preferably, as an improvement, the dosage form of the tranquilizer is tablets, granules, capsules or injections.

[0011] Preferably, as an improvement, a method for preparing a tranquilizing tea comprises the following steps:

[0012] Step 1: Select and prepare ingredients: Select authentic Chinese medicinal materials such as Chinese date seeds, lotus seeds, lilies, citrons, gastrodia elata, angelica, and licorice;

[0013] Step 2: Clean and dry;

[0014] Step 3: Mixing and blending: Mix and blend the dried medicinal materials according to the proportion.

[0015] Preferably, as an improvement, in step 2, the drying temperature is 30-50° C., and the drying time is 1-2 hours.

[0016] Preferably, as an improvement, in step 2, drying is performed in a sterile oven.

[0017] Preferably, as an improvement, in step three, after preparation, the medicinal materials are ground into granules with a particle size of 1-5 mm.

[0018] The principle and advantages of this scheme are: Ziziphus jujuba contains a variety of bioactive ingredients, such as saponins, flavonoids, etc., which have obvious sedative and tranquilizing effects and can improve sleep quality. Among them, the flavonoids in Ziziphus jujuba have an anti-anxiety effect and help relieve psychological pressure; the antioxidant ingredients help to scavenge free radicals and protect nerve cells. Lotus seeds (Nelumbo nucifera) have the effect of tonifying the spleen and strengthening the kidney, and can improve the insomnia symptoms caused by deficiency of both spleen and kidney. The ingredients such as nelumborine in lotus seeds have a certain tranquilizing effect and help improve sleep quality. Lily (Lilium brownii) has the effect of clearing the heart and tranquilizing the mind, and can relieve the insomnia symptoms caused by excessive heart fire. Lily also has the effect of moistening the lungs and relieving cough, which is helpful for insomnia caused by cough. In addition, the polyphenols in lily have antioxidant effects and help protect nerve cells. Citron (Citrus aurantium) has the effect of regulating qi and widening the chest, and can relieve the insomnia symptoms caused by qi stagnation. The volatile oil components in Citron have a certain calming effect, which helps to relax the body and mind. Gastrodia elata has the effect of calming the liver and extinguishing wind, which can relieve the insomnia symptoms caused by liver wind. The active ingredients in Gastrodia elata can calm the nerves and improve sleep quality. In addition, Gastrodia elata also has the effect of improving memory and has a certain protective effect on the nervous system. Angelica sinensis has the effect of nourishing blood and regulating menstruation, which can improve the insomnia symptoms caused by insufficient qi and blood. The active ingredients in Angelica sinensis have a certain calming effect, which helps to improve sleep quality. In addition, Angelica sinensis also has an antioxidant effect, which helps to protect the nervous system. Licorice (Glycyrrhiza uralensis) has the effect of harmonizing various medicines and can enhance the efficacy of other medicines. Licorice has the effect of invigorating qi and harmonizing the middle, which can improve the insomnia symptoms caused by qi deficiency. The above-mentioned medicinal materials are compounded into a traditional Chinese medicine prescription, which can give full play to their respective pharmacological effects and achieve a better calming effect. Moreover, through the combination of monarch, minister, assistant and guiding ingredients and the preparation method of the technical solution, the effective active ingredients of each medicine can be extracted and utilized to the maximum extent, the efficacy of each medicine and the efficacy of health products can be maximized, and their bioavailability can be improved, so as to reduce the dosage of original medicinal materials accordingly.

[0019] In summary, the beneficial effects of this technical solution are:

[0020] 1. In terms of the selection of Chinese medicinal materials, this technical solution strictly selects authentic medicinal materials, strictly controls different types of Chinese medicinal materials, and selects appropriate temperature-controlled boxes to dry the various components in the scented tea, thus overcoming the technical difficulties of properties and bioavailability between different components.

[0021] 2. In the present technical scheme, Chinese jujube seeds, lotus seeds and lilies all have a calming effect. Chinese jujube seeds enter the heart and liver meridians, can nourish the heart yin, benefit the liver blood, and calm the mind and nerves, and are the key medicines for calming the mind; lotus seeds enter the heart and kidney meridians, can nourish the heart and benefit the kidney, connect the heart and kidney, and calm the mind and nerves; lilies enter the heart meridian, can nourish yin and clear the heart, and calm the mind and nerves; using the three together has a significantly enhanced calming effect.

[0022] 3. Compared with traditional tranquilizing prescriptions, such as Cinnabar Tranquilizing Pills, this technical solution eliminates cinnabar, coptis root, raw rehmannia, etc. Although cinnabar is an important medicine for calming the nerves, it is poisonous and should not be taken for a long time; coptis root tastes bitter, has a low tolerance, and long-term use can easily damage the spleen and stomach; raw rehmannia is cold in nature, and should not be used by those with weak spleen and stomach. Therefore, by eliminating the above ingredients, the side effects can be reduced by reducing the prescription while ensuring its tranquilizing effect.

[0023] 4. In this technical solution, by optimizing the drying conditions, it is possible to facilitate the storage of flowers. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The present invention is a preparation process flow chart of the tranquilizing tea. DETAILED DESCRIPTION

[0025] The following is further described in detail through specific implementations, but the implementation of the present invention is not limited thereto. Unless otherwise specified, the technical means used in the following implementations are conventional means well known to those skilled in the art; the experimental methods used are all conventional methods; the materials, reagents, etc. used can all be obtained from commercial channels.

[0026] Program Overview:

[0027] like Figure 1 As shown: A tranquilizing tea, comprising the following raw materials, by weight: 10-20 parts of Chinese jujube seeds, 10-20 parts of lotus seeds, 10-20 parts of lilies, 10-20 parts of citrons, 3-6 parts of gastrodia elata, 5 parts of angelica sinensis, and 6 parts of liquorice, wherein the Chinese jujube seeds are fried Chinese jujube seeds.

[0028] A method for preparing a tranquilizing tea comprises the following steps:

[0029] Step 1: Select and prepare ingredients: Select authentic Chinese medicinal materials such as Chinese date seeds, lotus seeds, lilies, citrons, gastrodia elata, angelica, and licorice;

[0030] Step 2: Cleaning and drying: Clean the selected Chinese medicinal materials to remove dust and impurities on the surface; rinse gently with running water, and be careful not to rub hard to avoid damaging the structure of the medicinal materials; after cleaning, dry the medicinal materials in the air or wipe them with clean gauze, and then put them in the oven to dry to remove excess moisture and prevent them from getting moldy and deteriorating;

[0031] Step 3: Mixing and blending: After sorting the dried medicinal materials, the medicinal material particles are mixed according to the established proportion of the medicine to achieve the desired effect. When mixing, you can adjust it according to your personal taste and physical characteristics to achieve the best effect.

[0032] Example 1

[0033] A tranquilizing tea comprises the following raw materials: 10g of fried spiny jujube seeds, 10g of lotus seeds, 10g of lily bulbs, 10g of citron, 3g of gastrodia elata, 5g of angelica root and 6g of liquorice root.

[0034] A method for preparing a tranquilizing tea comprises the following steps:

[0035] Step 1: Ingredients selection and preparation: stir-fry 10g of spiny jujube kernel, 10g of lotus seed, 10g of lily, 10g of citron, 3g of gastrodia elata, 5g of angelica root, and 6g of licorice root;

[0036] Step 2: Cleaning and drying: Clean the selected Chinese medicinal materials to remove dust and impurities on the surface; rinse gently with running water, and be careful not to rub hard to avoid damaging the structure of the medicinal materials; after cleaning, dry the medicinal materials in the air or wipe them with clean gauze, and then put them in the oven to dry to remove excess moisture and prevent them from getting moldy and deteriorating;

[0037] Step 3: Mixing and blending: After sorting the dried medicinal materials, the medicinal material particles are mixed according to the established proportion of the medicine to achieve the desired effect. When mixing, you can adjust it according to your personal taste and physical characteristics to achieve the best effect.

[0038] Example 2

[0039] A tranquilizing tea comprises the following raw materials: 20g of fried sour jujube seeds, 20g of lotus seeds, 20g of lily, 20g of citron, 6g of gastrodia elata, 5g of angelica root and 6g of liquorice.

[0040] A method for preparing a tranquilizing tea comprises the following steps:

[0041] Step 1: Ingredients selection and preparation: stir-fry 20g of sour jujube kernel, 20g of lotus seed, 20g of lily, 20g of citron, 6g of gastrodia elata, 5g of angelica root, and 6g of licorice root;

[0042] Step 2: Cleaning and drying: Clean the selected Chinese medicinal materials to remove dust and impurities on the surface; rinse gently with running water, and be careful not to rub hard to avoid damaging the structure of the medicinal materials; after cleaning, dry the medicinal materials in the air or wipe them with clean gauze, and then put them in the oven to dry to remove excess moisture and prevent them from getting moldy and deteriorating;

[0043] Step 3: Mixing and blending: After sorting the dried medicinal materials, the medicinal material particles are mixed according to the established proportion of the medicine to achieve the desired effect. When mixing, you can adjust it according to your personal taste and physical characteristics to achieve the best effect.

[0044] Example 3

[0045] A tranquilizing tea comprises the following raw materials: 20g of fried spiny jujube seeds, 20g of lotus seeds, 10g of lily bulbs, 10g of citron, 3g of gastrodia elata, 5g of angelica root and 6g of liquorice root.

[0046] A method for preparing a tranquilizing tea comprises the following steps:

[0047] Step 1: Ingredients selection and preparation: stir-fry jujube seeds 20g, lotus seeds 20g, lily 10g, citron 10g, gastrodia 3g, angelica 5g, licorice 6g;

[0048] Step 2: Cleaning and drying: Clean the selected Chinese medicinal materials to remove dust and impurities on the surface; rinse gently with running water, and be careful not to rub hard to avoid damaging the structure of the medicinal materials; after cleaning, dry the medicinal materials in the air or wipe them with clean gauze, and then put them in the oven to dry to remove excess moisture and prevent them from getting moldy and deteriorating;

[0049] Step 3: Mixing and blending: After sorting the dried medicinal materials, the medicinal material particles are mixed according to the established proportion of the medicine to achieve the desired effect. When mixing, you can adjust it according to your personal taste and physical characteristics to achieve the best effect.

[0050] Experimental Example 1 Safety Toxicology Study

[0051] 1 Experimental Materials

[0052] 1.1 Main instruments, equipment and reagents

[0053] Dissecting instruments, electronic balances, refrigerators, centrifuges, etc. are commonly used in laboratories.

[0054] Reagent: 0.1% colchicine, in a brown bottle, stored in the refrigerator.

[0055] 1% trisodium citrate: take 1g trisodium citrate (analytical grade) and add distilled water to make up to 100mL.

[0056] 60% glacial acetic acid: Take 60 mL of glacial acetic acid (analytical grade) and add distilled water to 100 mL.

[0057] Fixative: V methanol: V glacial acetic acid = 3:1, prepare before use.

[0058] Phosphate buffer (pH 7.4): Disodium hydrogen phosphate (NaHPO, analytical grade) 9.47 g was dissolved in 1 000 mL of distilled water to prepare disodium hydrogen phosphate solution (1 / 15 mol / ): Disodium dihydrogen phosphate (KHPO, analytical grade) 9.07 g was dissolved in 1 000 mL of distilled water to prepare potassium dihydrogen phosphate solution (1 / 15 mol / ). Mix 80 mL of disodium hydrogen phosphate solution (1 / 15 mol / L) with 20 mL of potassium dihydrogen phosphate solution (1 / 15 mol / L) and adjust the pH to 7.4.

[0059] Giemsa dye solution: Weigh 3.8g of Giemsa dye solution, add 375mL methanol (analytical grade) and grind. After it is completely dissolved, add 125mL glycerol. Keep it in a 37℃ thermostat for 48h and shake it several times. Filter it and use it after two weeks.

[0060] Giemsa application solution: Mix 1 part of Giemsa stain with 9 parts of phosphate buffer and prepare it before use.

[0061] 1.2 Preparation of experimental materials

[0062] 1.2.1 Preparation of tranquilizing tea

[0063] Select authentic medicinal materials such as Chinese date seeds, lotus seeds, lilies, citrons, gastrodia elata, angelica and liquorice; wash and dry: wash with water and then dry (temperature is 30-45°C); mix and grind: mix according to proportion and then grind to obtain tranquilizing tea (particle size after grinding is 1-5 mm).

[0064] 1.2.2 Acute toxicity test sample processing

[0065] Weigh 15g of the Anshen Tea sample into a beaker, add 150mL of pure water, soak at 80℃ for 30min, and pour out the soaking liquid; add another 150mL of pure water, soak at 80℃ for 30min, and pour out the soaking liquid. Combine the two soaking liquids, heat and concentrate to 20mL, pour into a reagent bottle, mark and set aside.

[0066] 1.2.3 Sample processing for mouse sperm abnormality experiment

[0067] Weigh 30g of the Anshen Tea sample into a beaker, add 150mL of pure water, soak at 80℃ for 30min, and pour out the soaking liquid; add another 150ml of pure water, soak at 80℃ for 30min, and pour out the soaking liquid. Combine the two soaking liquids, heat and concentrate to 60mL, as the highest dose of 10,000mg / kg. Take 15mL of the highest dose solution and dilute it by one-fold to 5,000mg / kg. Take 5mL of the highest dose solution and dilute it ten-fold to 1,000mg / kg.[3]1.2.4 Experimental Animals

[0068] Clean-grade ICR mice were provided by Zhejiang Experimental Animal Center, with the license number SCXK(Zhejiang)2014-0001. A total of 20 mice were used for the acute oral toxicity test, including 10 males and 10 females. A total of 25 male mice were used for the mouse spermatogonial abnormality test.

[0069] Animals in each test group were housed in separate cages according to gender. Animals in each cage were allowed to move freely; a relaxed environment was maintained to facilitate observation. During the test, experimental animals were fed with basic feed and free drinking water was guaranteed. Before the test, experimental animals were required to undergo 3 days of environmental adaptation and quarantine observation in the test environment. They were fasted for 4 hours before the test, but free drinking water was allowed.

[0070] Select healthy adult mice (18-22 g) of both sexes. Female animals should be virgin and non-pregnant. The weight difference between individual experimental animals of the same sex should not exceed ±20% of the average weight.

[0071] Experimental methods

[0072] 2.1 Acute toxicity test method

[0073] Administration route: oral administration,

[0074] The maximum tolerated dose method was used, and the oral dose was 15,000 mg / kg; the animals were fasted for 16 hours before exposure. After exposure, the poisoning symptoms or behavioral changes were observed every day, and the animals were weighed once a week. The animals that died of poisoning and the animals that survived 14 days after exposure were dissected and observed.

[0075] 2.2 Experimental methods of mouse sperm abnormality

[0076] 2.2.1 Contamination and testing

[0077] The animals in each group were exposed to the drug for 5 consecutive days. The mice were killed by cervical dislocation on the 30th day after the last administration of the test substance. The epididymis was taken to make saline suspension smears, 5 pieces per group, dried naturally, fixed with methanol for 7 minutes, dried, stained with eosin, and examined under a microscope.

[0078] 2.2.2 Control group

[0079] Purified water was used as the negative control group. Except for not using the test sample, other treatments were the same as those of the test substance group.

[0080] The positive control was cyclophosphamide (40 mg / kg body weight, single intraperitoneal injection).

[0081] 2.2.3 Dosage

[0082] The test substance was divided into three dosage groups: 1000, 5000, and 10000 mg / kg.

[0083] 2.3 Experimental Environment

[0084] Barrier environment animal room, use license number: SYXK(Zhejiang)2016-0012, room temperature 21.5~25.0℃; relative humidity 52.0%~65.0%.

[0085] 3 Results and Analysis

[0086] 3.1 Acute toxicity test

[0087] All experimental animals showed ataxia symptoms 4 hours after exposure to the poison. After 24 hours, the symptoms disappeared and the animals returned to normal. No poisoning deaths were found within 14 days. The weight of male and female animals was normal. After the experimental observation, the animals were dissected and observed, and no abnormalities were found. The oral gavage experiment on mice with the sample showed that the LD50 was > 15,000 mg / kg. According to the acute toxicity classification, the sample belongs to the oral non-toxic level, see Table 1.

[0088] Table 1 Results of acute oral toxicity test of tranquilizing tea

[0089]

[0090] 3.2 Mouse sperm abnormality experiment

[0091] The experimental results (Table 2) showed that compared with the negative control group, the positive control group treated with 40 mg / kg cyclophosphamide caused a significant increase in the number of abnormal sperm in mice, while there was no significant difference in the number of abnormal sperm in mice in each drug-treated group compared with the negative control group.

[0092] The test substance was divided into three dosage groups: 1000, 5000, and 10000 mg / kg. Compared with the negative control group, there was no significant difference in the sperm deformity rate. The sperm deformity rate of the test substance in mice was within the normal deformity range, and no genetic toxicity of the test substance to mouse male germ cells was observed.

[0093] Table 2 Results of the experiment on sperm abnormality caused by Anshen tea in mice

[0094]

[0095] Note: The positive control is cyclophosphamide, 40 mg / kg; the negative control is purified water.

[0096] Experimental Example 2

[0097] The therapeutic effect of the Chinese medicinal tea substitute "Anshen Tea" prepared in Example 1, which is used to calm the mind, relieve depression, nourish the heart and soothe the nerves, on insomnia.

[0098] 40 volunteers who met the diagnostic criteria for insomnia were selected, with no gender or age restrictions. They were randomly divided into 4 groups, marked as measurement group A, measurement group B, measurement group C and blank group. The "Anshen Tea" A prepared in Example 1 was used for measurement group A, the "Anshen Tea" B prepared in Example 2 was used for measurement group B, the "Anshen Tea" C prepared in Example 3 was used for measurement group C, and boiled water was used for the blank group; 1 bag of "Anshen Tea" was taken every day, brewed with boiling water, and can be brewed repeatedly until it is light and tasteless, for 14 consecutive days. During this period, the patient's Pittsburgh Sleep Quality Rating (PSQI) scale was recorded, and the PSQI scale was used to evaluate sleep quality, with a total of 7 items and a total score of 21 points. The higher the score, the worse the sleep, and vice versa.

[0099] Table 3 Comparison of PSQI scores before and after treatment in the three groups of patients ( point)

[0100]

[0101]

[0102] Note: Compared with the time of entry, *P<0.05; compared with the blank group, #P<0.05

[0103] Continuous 14-day observation and comparison show that the "Anshen Tea" has a good effect of nourishing the mind and improving sleep. The "Anshen Tea" of the present invention has the effects of calming the mind, relieving depression, nourishing the heart and calming the mind, and can be used to relieve insomnia.

[0104] Experimental Example 3 Animal Experiment

[0105] Experimental groups and experimental methods: 40 ICR mice were adaptively raised for 1 week and randomly divided into control group, model group, diazepam (DZP) group and anshen tea group, with 10 mice in each group. The model group, diazepam and anshen tea groups were intraperitoneally injected with PCPA suspension (400 mg / (kg·d), 10 mL / kg) for 5 consecutive days. The disappearance of the circadian activity rhythm of the mice, irritability and weight loss indicated that the model was successfully established.

[0106] At 7:30 the next day after modeling, mice in the diazepam and anshen tea groups were gavaged with anshen tea and diazepam. 30 minutes after the last administration, i.e., at 8:00, mice in each group were intraperitoneally injected with 45 mg / kg sodium pentobarbital aqueous solution, and the sodium pentobarbital-induced righting reflex test was performed. The sleep latency and sleep duration were recorded, as shown in Table 4:

[0107] Table 4

[0108] Group Sleep latency (min) Sleep duration (min) Blank group 3.62±0.26 59.45±19.21 Model Group 4.18±0.39 33.59±15.23 Diazepam group 2.21±0.23 119.65±26.97 Calming Tea Set 2.84±0.36 76.28±29.31

[0109] As can be seen from the table above, compared with the blank control group, the sleep latency of the mice in the model group was significantly prolonged, and the sleep duration was significantly shortened, indicating that the model was successfully established. Compared with the mice in the model group, the sleep latency of the mice in the diazepam group and the Anshen Tea group was significantly shortened, and the sleep duration was significantly prolonged. The above results show that Anshen Tea can significantly shorten the sleep latency of insomnia mice and significantly prolong their sleep duration, thereby improving the sleep condition of insomnia mice.

[0110] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A calming tea, characterized in that: The invention comprises the following raw materials, by weight: 10-20 parts of spiny jujube seeds, 10-20 parts of lotus seeds, 10-20 parts of lilies, 10-20 parts of citrons, 3-6 parts of gastrodia elata, 5 parts of angelica sinensis and 6 parts of liquorice.

2. The soothing tea according to claim 1, characterized in that: The weight proportions of the raw materials are 10 parts of spiny jujube seeds, 10 parts of lotus seeds, 10 parts of lilies, 10 parts of citrons, 3-6 parts of gastrodia elata, 5 parts of angelica sinensis, and 6 parts of liquorice.

3. A soothing tea according to claim 2, characterized in that: The Chinese jujube seeds are fried Chinese jujube seeds.

4. Use of the tranquilizing tea according to any one of claims 1 to 3 in the preparation of tranquilizing medicines.

5. The use of the tranquilizing tea according to claim 4 in preparing tranquilizing medicines, characterized in that: The dosage form of the tranquilizer is tablet, granule, capsule or injection.

6. The method for preparing a tranquilizing tea according to any one of claims 1 to 3, characterized in that: The steps include: Step 1: Select and prepare ingredients: Select authentic Chinese medicinal materials such as Chinese date seeds, lotus seeds, lilies, citrons, gastrodia elata, angelica, and licorice; Step 2: Clean and dry; Step 3: Mixing and blending: Mix and blend the dried medicinal materials according to the proportion.

7. The method for preparing a tranquilizing tea according to claim 6, characterized in that: In step 2, the drying temperature is 30-50° C. and the drying time is 1-2 hours.

8. The method for preparing a tranquilizing tea according to claim 7, characterized in that: In step 2, drying is performed in a sterile oven.

9. The method for preparing a tranquilizing tea according to claim 8, characterized in that: In step three, after preparation, the medicinal materials are ground into granules with a particle size of 1 to 5 mm.