Atomizing device

Abstract

The present application relates to an atomization device, comprising: a container assembly comprising a container and a sealing plug, the container having a first end and a second end; a piston assembly comprising a piston rod, a first piston and a second piston; in the container cavity, the side of the second piston away from the sealing plug forms a first chamber, and the second chamber is formed between the second piston and the sealing plug; the first chamber is used to contain the first raw material, and the second chamber is used to contain the second raw material; when the piston rod pushes the first piston to move in the first direction relative to the second piston, the first raw material enters the second chamber and mixes with the second raw material to form a mixture, and in the process, the sealing plug is separated from the first end under the extrusion of the mixture. The atomization device of the present application has the advantages of simple structure, small size, easy operation, reduced waste of mixture, accurate dose, and the ability to maintain the complete structure and biological activity of the drug during delivery.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of inhalation devices, in particular to an atomization device. BACKGROUND

[0002] The molecular weight of nanobodies is small, the structure is stable, and the tolerance is strong, which is suitable for developing various drug delivery routes, including intravenous injection, subcutaneous administration, oral administration, atomization inhalation and the like. The inhalation administration of nanobodies can avoid the first-pass effect of oral administration, and shows good curative effect in the treatment of lung diseases, and will have good application prospect in the treatment of respiratory and lung diseases.

[0003] The freeze-dried powder is a common storage method of nanobodies. The powdery drug powder is stored in a penicillin bottle, and after adding sterile water, the reconstituted solution is obtained, and then the drug delivery process is carried out.

[0004] When the existing atomization device is used for drug delivery, the reconstituted solution needs to be added into the air compression or vibration type atomization device first. The atomization device can convert the antibody drug into thin mist or aerosol particles of appropriate size. The particle size distribution of the atomized particles will directly affect the subsequent inhalation and treatment effect. The atomization inhalation scheme has the following disadvantages:

[0005] (1) The drug administration procedure is complex. The user needs to first reconstitute the powdery drug powder with sterile water, then add the reconstituted solution into the atomization device, and then perform atomization inhalation. Moreover, the reconstituted solution will be in direct contact with air during the process of being added into the atomization device. Since new air is introduced, there is a risk of contamination.

[0006] (2) The air compression or vibration type atomization device is large in size and complex in structure. For small-dose liquid drug atomization work, the liquid drug is wasted seriously, which affects the treatment effect.

[0007] (3) The physicochemical properties of nanobody drugs are relatively complex. Through the existing air compression or vibration type atomization device for drug delivery, the drug needs to be able to withstand the high pressure and force output by the atomization device, and maintain the complete structure of the drug and the biological activity of the drug during the delivery process. SUMMARY

[0008] Based on the above-mentioned defects in the prior art, the purpose of the present application is to provide an atomization device which is simple and small in structure, convenient to carry, has few preparation steps, easy to operate, can reduce the waste of mixed materials for small-dose atomization work, and has more accurate dose. For drugs with relatively complex physicochemical properties, the complete structure of the drug and the biological activity of the drug can be maintained during the delivery process.

[0009] To this end, the present application provides the following technical solutions.

[0010] The application provides an atomization device, which comprises:

[0011] a container assembly comprising a container and a sealing plug, the container having a first end in an open state and a second end, and the sealing plug being used to seal the first end;

[0012] a piston assembly comprising a piston rod, a first piston and a second piston, the first piston and the second piston being sequentially arranged in the container in a first direction, and one end of the piston rod being located in the container and being linked with the first piston;

[0013] wherein, in the container cavity, a side of the second piston away from the sealing plug forms a first chamber, and a second chamber is formed between the second piston and the sealing plug; the first chamber is used to contain a first raw material, and the second chamber is used to contain a second raw material;

[0014] when the piston rod pushes the first piston to move relative to the second piston in the first direction, the first raw material enters the second chamber and mixes with the second raw material to form a mixed material, and in this process, the sealing plug is separated from the first end under the extrusion of the mixed material.

[0015] Optionally, in the process of assembling the piston rod in the container, the piston rod pushes the first piston to move relative to the second piston in the first direction, so that the first raw material enters the second chamber.

[0016] Optionally, when the first piston moves in the first direction to abut against the second piston, the first raw material completely enters the second chamber.

[0017] Optionally, the first raw material is in a liquid state, and the second raw material is in a lyophilized powder state or a liquid state.

[0018] Optionally, the second raw material is a nanobody in a lyophilized powder state.

[0019] Optionally, the sealing plug is a rubber plug.

[0020] Optionally, an inner wall of the container is provided with a groove, and a communication flow channel is formed between the outer wall of the second piston and the groove; the first chamber and the second chamber are communicated through the communication flow channel.

[0021] under the extrusion of the first piston or under the action of the air pressure of the first chamber, the first raw material enters the second chamber through the communication flow channel.

[0022] Optionally, the atomization device further comprises an atomization chip located outside the sealing plug.

[0023] When the liquid pressure of the liquid flowing out of the first end reaches a preset value, the liquid is formed into atomized fine particles through the atomization chip processing and then escapes.

[0024] Optionally, the sealing plug is arranged in the port of the first end and is in interference fit with the port.

[0025] Optionally, when the sealing plug is separated from the first end, the sealing plug is in abutment with the atomization chip under the extrusion of the mixed material.

[0026] Optionally, the sealing plug comprises a sealing plug body and a plurality of protruding structures arranged on a side of the sealing plug body facing the atomization chip.

[0027] When the sealing plug is separated from the first end, the protruding structures are used to form a first gap between the sealing plug body and the atomization chip, and the mixed material in the second chamber flows to the atomization flow channel of the atomization chip through the first gap.

[0028] Optionally, the atomization device further comprises a pen barrel provided with a first hollow column and a second hollow column connected in sequence in a first direction; the container assembly and the piston assembly are arranged in the pen barrel, and the atomization chip is mounted in the second hollow column.

[0029] When the sealing plug is separated from the first end, the sealing plug body is located in the first hollow column, a second gap is formed between the circumferential wall of the sealing plug body and the inner wall of the first hollow column, and the second chamber, the second gap, the first gap and the atomization flow channel are sequentially communicated.

[0030] Optionally, the transverse spatial size of the first hollow column is greater than the transverse spatial size of the second hollow column; when the sealing plug is separated from the first end, the protruding structures are in abutment with the end face of the second hollow column, so as to reduce or completely avoid the coverage of the protruding structures on the atomization flow channel.

[0031] Optionally, the sealing plug body comprises a first column body and a second column body connected in sequence in a first direction.

[0032] The first column body is frustoconical, and gradually expands in the first direction.

[0033] The second column body is cylindrical, and the outer diameter of the second column body is greater than or equal to the maximum outer diameter of the first column body; when the sealing plug is assembled in the port of the first end, the outer wall of the second column body is in interference fit with the inner wall of the first end.

[0034] Optionally, the protruding structures are partially protruded outward from the circumferential wall of the second column body.

[0035] When the sealing plug is assembled in the port of the first end, the protruding structure is extruded by the inner wall of the first end and deformed.

[0036] Optionally, the atomization device further comprises a pen cap connected to the first end of the pen barrel.

[0037] The pen cap is provided with a sealing column which is inserted into the second hollow column and is in interference fit with the second hollow column to seal the first end of the pen barrel.

[0038] Optionally, the atomization device further comprises a pen cap connected to the second end of the pen barrel to seal the second end of the pen barrel.

[0039] Optionally, the atomization device further comprises a retaining member for retaining the container and mounted in the pen barrel.

[0040] Optionally, the atomization device further comprises a pen barrel and a trigger assembly, the container assembly and the piston assembly are both arranged in the pen barrel; the trigger assembly comprises:

[0041] an operating mechanism movably mounted on the pen barrel;

[0042] a pawl rotatably connected to the operating mechanism, the pawl being configured to engage with the ratchet structure provided on the piston rod;

[0043] When the operating mechanism is moved in a first direction under an external force, the pawl pushes the ratchet structure to move the piston rod in the first direction, and the piston rod pushes the first piston and the second piston to move to trigger atomization.

[0044] When the operating mechanism is moved in a second direction, the piston rod does not move together, and the first direction is opposite to the second direction.

[0045] Optionally, the operating mechanism is provided with a limiting structure for limiting the rotation angle of the pawl to enable the pawl to maintain engagement with the ratchet structure during movement of the operating mechanism in the first direction.

[0046] Optionally, the operating mechanism comprises:

[0047] an operating element at least partially located outside the pen barrel;

[0048] an adapter element located inside the pen barrel and connected to the operating element, and the pawl is rotatably connected to the adapter element.

[0049] Optionally, the atomization device further comprises a pen cap connected to the second end of the pen barrel to seal the second end of the pen barrel.

[0050] The cap is provided with a limiting slot, and the piston rod is provided with a limiting protrusion; the limiting slot and the limiting protrusion are connected to limit rotation of the piston rod relative to the cap.

[0051] Optionally, the cap is further provided with a containing slot; when the atomization device is in an initial state, the ratchet structure is partially located in the containing slot.

[0052] Optionally, the atomization device further comprises a cap connected to the first end of the barrel;

[0053] When the atomization device is assembled, the piston rod is assembled with the first piston to form a first pre-assembly component, and the barrel is assembled with the cap to form a second pre-assembly component; then, the first pre-assembly component and the second pre-assembly component are assembled, and when the assembly is completed, the pawl is engaged with the ratchet structure.

[0054] The present application has the following technical effects:

[0055] The present application provides an atomization device, by configuring a first piston and a second piston in a container, and forming a first chamber and a second chamber, a first raw material and a second raw material can be respectively contained, when a user needs to use the atomization device, the first piston is driven to move by a piston rod, so that the first raw material is moved into the second chamber and mixed with the second raw material, realizing the mixing of the two raw materials. Without manual operation of the user to mix the two raw materials, the preparation steps are less, the operation steps are simplified, new air is not introduced in the mixing process of the first raw material and the second raw material, the pollution risk is reduced, the atomization device is simple and small in structure, convenient to carry, for small-dose atomization work, the waste of mixed materials can be reduced, the dose is more accurate, in addition, the atomization device of the present application provides power through the piston rod to realize atomization, the pressure of the output of the mixed materials is smaller, for the drugs with relatively complex physicochemical properties, the structure and biological activity of the drugs can be maintained during the delivery process. BRIEF DESCRIPTION OF DRAWINGS

[0056] Figure 1 It is a structure sectional view of the atomization device of the present application in an unatomized state;

[0057] Figure 2 It is a structure sectional view of the container assembly, the first piston and the second piston of the present application when assembled;

[0058] Figure 3 It is Figure 1 It is an enlarged view of A in the middle;

[0059] Figure 4Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0060] Figure 5 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0061] Figure 6 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0062] Figure 7 Structure sectional view of the atomizing device in the process of primary atomization according to the present application; Figure 1 ;

[0063] Figure 8 Structure sectional view of the atomizing device in the process of primary atomization according to the present application; Figure 2 ;

[0064] Figure 9 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0065] Figure 10 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0066] Figure 11 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0067] Figure 12 Structure sectional view of the atomizing device in the process of primary atomization according to the present application;

[0068] Figure 13 Structure sectional view of the atomizing device in the process of primary atomization according to the present application.

[0069] Explanation of reference numerals

[0070] 100, atomizing device;

[0071] 1, container assembly; 11, container; 111, first end; 112, second end; 113, groove; 12, sealing plug; 121, sealing plug body; 1211, first cylinder; 1212, second cylinder; 122, protruding structure; 13, bottle cap;

[0072] 2, piston assembly; 21, piston rod; 211, ratchet structure; 212, limiting protrusion; 213, clamping portion; 22, first piston; 221, clamping groove; 23, second piston;

[0073] 31, first cavity; 32, second cavity;

[0074] 4, atomizing chip; 41, atomizing flow channel;

[0075] 51, first gap; 52, second gap;

[0076] 61, pen container; 611, first hollow column; 612, second hollow column; 6121, end face; 613, buckling convex; 614, external thread; 615, long hole; 616, mounting hole;

[0077] 62, pen cover; 621, sealing column; 622, buckling groove; 623, sliding groove;

[0078] 63, pen cap; 631, limiting groove; 632, accommodating groove; 633, internal thread;

[0079] 7, retaining member;

[0080] 8, trigger assembly; 81, operating mechanism; 811, operating element; 8111, connecting block; 812, adapter element; 8121, limiting structure; 82, pawl; 83, pivot shaft;

[0081] 9, visual window. DETAILED DESCRIPTION

[0082] In order to make the technical solutions and beneficial effects of the present application more obvious and easy to understand, the following will be described in detail by listing specific embodiments. Unless otherwise defined, the technical and scientific terms used herein have the same meaning as the technical and scientific terms in the technical field to which the present application belongs.

[0083] In the description of the present application, unless otherwise explicitly defined, the orientations or positional relationships indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of the simplified description of the present application, and do not indicate that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, that is, cannot be understood as a limitation on the present application.

[0084] In the present application, the terms "first" and "second" are only used for the purpose of clear description, and cannot be understood as the relative importance of the indicated features or the number of indicated technical features. Therefore, the features defined with "first" and "second" can explicitly include at least one of the features. In the description of the present application, the meaning of "multiple" is at least two; the meaning of "several" is at least one; except for explicit definition.

[0085] In the present application, unless otherwise explicitly defined, the terms "mounting", "connecting", "connecting", "fixing", "arranging" and the like should be interpreted in a broad sense. For example, "connecting" can be fixed connection, detachable connection or integral molding; can be mechanical connection or electrical connection; can be direct connection or indirect connection through intermediate medium; or can be internal connection of two elements or interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0086] In the present application, unless otherwise explicitly defined, the first feature "on", "over", "above" and "on", "under", "below", or "under" the second feature can be direct contact between the first feature and the second feature, or indirect contact between the first feature and the second feature through intermediate medium. Moreover, the first feature "over", "above" and "on" the second feature can be directly above or obliquely above the first feature, or only indicate that the horizontal height of the first feature is higher than the horizontal height of the second feature. The first feature "below", "below" and "under" the second feature can be directly below or obliquely below the first feature, or only indicate that the horizontal height of the first feature is less than the horizontal height of the second feature.

[0087] In the present application, "first direction a" and "second direction b" are indicated in Figure 1 and Figure 2 .

[0088] The atomizing device of the present application will be described in detail below according to Figures 1 to 13 .

[0089] In the present embodiment, as shown in Figure 1 and Figure 2 , the atomizing device 100 comprises a container assembly 1 and a piston assembly 2, the container assembly 1 comprises a container 11 (such as a cassette bottle) having a first end 111 in an open state and a second end 112, and a sealing plug 12 for sealing the first end 111, and the container 11 and the sealing plug 12 are assembled to hold raw materials. The piston assembly 2 comprises a piston rod 21, a first piston 22 and a second piston 23, the first piston 22 and the second piston 23 are sequentially arranged in the container 11 along the first direction a, and one end of the piston rod 21 is located in the container 11 and connected with the first piston 22.

[0090] When the second piston 23 is assembled in the container 11, the side of the second piston 23 facing away from the sealing plug 12 forms a first chamber 31 in the cavity of the container 11, and the second chamber 32 is formed between the second piston 23 and the sealing plug 12. The first chamber 31 is used to contain the first raw material, and the second chamber 32 is used to contain the second raw material. When the piston rod 21 pushes the first piston 22 to move in the first direction a in the container 11 relative to the second piston 23, the first raw material enters the second chamber 32 under the extrusion of the first piston 22 or under the action of the air pressure in the first chamber 31, and mixes with the second raw material to form a mixture. And in the process of the first raw material entering the second chamber 32 or when the first raw material completely enters the second chamber 32, the sealing plug 12 is separated from the first end 111 under the extrusion of the mixture. When the mixing of the first raw material and the second raw material is completed, the user can use the atomization device for inhalation, and by pushing the first piston 22 and the second piston 23 to move through the piston rod 21, atomization can be achieved.

[0091] It should be understood that since the first piston 22 and the second piston 23 need to be assembled from the second end 112 of the container 11, the opening of the second end 112 is larger, which causes a gap between the inner wall of the second end 112 of the container 11 and the piston rod 21, so when the first chamber 31 is not closed by the first piston 22, attention should be paid to place the second end 112 of the container 11 upward to avoid the first raw material in the first chamber 31 from spilling out of the second end 112, and when the first piston 22 is assembled in the container 11, the placement direction of the container 11 is not limited. Of course, a plug can also be configured at the second end 112 of the container 11 to prevent the first raw material in the first chamber 31 from spilling out of the second end 112, and the placement direction of the container 11 is not limited, and when the piston rod 21 needs to be assembled, the plug can be removed.

[0092] In the technical solution, the first piston 22 and the second piston 23 are arranged in the container 11, and the first chamber 31 and the second chamber 32 are formed, so that the first raw material and the second raw material can be respectively accommodated. When a user needs to use the atomization device, the first piston 22 is first driven to move relative to the second piston 23 by the piston rod 21, so that the first raw material is moved into the second chamber 32 and mixed with the second raw material, and the mixing of the two raw materials is realized. Then, the user can use the atomization device 100 for atomization and inhalation. Compared with the technical solution of the prior art that uses an air compression or vibration type atomization device, the present solution does not require the user to manually mix the two raw materials, and the preparation steps are less and the operation steps are simplified. In the process of mixing the first raw material and the second raw material, new air is not introduced, and the pollution risk is reduced. In addition, the structure of the atomization device of the present solution is simple and small, and is convenient to carry. For small-dose atomization work, the waste of mixed materials (such as liquid medicine) can be reduced, and the dose is more accurate. In addition, the atomization device of the present solution is powered by the piston rod 21 to realize atomization, and the pressure output to the mixed materials is small. For drugs with relatively complex physicochemical properties (such as nanobody drugs), the structure and biological activity of the drug are maintained during delivery.

[0093] In an embodiment, as shown in Figure 1 , Figure 2 , in the process of assembling the piston rod 21 to the container 11, the piston rod 21 pushes the first piston 22 to move relative to the second piston 23 in the first direction a, so that the first raw material enters the second chamber 32. That is, in the process of assembling the atomization device 100, the mixing of the first raw material and the second raw material is completed, and the operation is convenient. Regarding the linkage of the piston rod 21 and the first piston 22, the first piston 22 can be first linked with the piston rod 21, and then the first piston 22 and the piston rod 21 are assembled with the container 11. In this way, in the process of inserting the piston rod 21 and the first piston 22 into the container 11, the first raw material in the first chamber 31 moves to the second chamber 32. Of course, the first piston 22 can be first assembled into the container 11, and then the piston rod 21 is inserted into the container 11, and the linkage of the piston rod 21 and the first piston 22 is completed during the insertion.

[0094] In an embodiment, as shown in Figure 1 , Figure 2 , Figure 6 , and Figure 9 , one end of the piston rod 21 is provided with a clamping portion 213, and the first piston 22 is provided with a clamping groove 221. The clamping portion 213 and the clamping groove 221 are clamped with each other to link the piston rod 21 and the first piston 22. When assembling the atomization device 100, the piston rod 21 and the first piston 22 are first assembled, and then assembled with the container 11.

[0095] In an embodiment, as shown in Figure 1 and Figure 2 When the first piston 22 moves to abut against the second piston 23 along the first direction a, the first raw material completely enters the second chamber 32, so that when the aerosol inhalation is needed, the second piston 23 can be immediately pushed to move synchronously when the first piston 22 is pushed to move along the first direction a by the piston rod 21, so that the aerosolization can be quickly realized. Of course, when the first raw material completely enters the second chamber 32, there can also be a gap between the first piston 22 and the second piston 23, so that when the aerosol inhalation is needed, the second piston 23 can be pushed to move synchronously after the first piston 22 is pushed to move along the first direction a to contact the second piston 23 by the piston rod 21.

[0096] In an embodiment, the first raw material is in a liquid state, and the first raw material can be a medicine liquid or sterile water for injection, and the second raw material is in a freeze-dried powder state or a liquid state, and the first raw material in the liquid state can more easily flow into the second chamber 32 from the first chamber 31.

[0097] Further, the second raw material is a nanobody in a freeze-dried powder state, and at present, the main aerosolization supply mode of the nanobody is to use an air compression or vibration type aerosolization device, or to inhale in the form of a dry powder. The aerosolization device of the present scheme is applied to the aerosolization of the nanobody in the freeze-dried powder state. Compared with the air compression or vibration type aerosolization device, the preparation steps are less, the operation steps are simplified, the pollution risk is reduced, the dose is more accurate, and the structure and biological activity of the medicine are maintained during the delivery process. Compared with the inhalation in the form of a dry powder, the aerosolization device of the present scheme inhales in the form of aerosolized fine particles, the flow rate is lower, and the comfort is higher.

[0098] In an embodiment, the sealing plug 12 is a rubber plug, which is simple in structure, good in sealing property and elastic.

[0099] In an embodiment, as shown in Figure 2 The inner wall of the container 11 is provided with a groove 113, and the groove 113 and the outer wall of the second piston 23 form a communication flow channel, and the first chamber 31 and the second chamber 32 are communicated through the communication flow channel. Under the extrusion of the first piston 22 or under the action of the air pressure of the first chamber 31, the first raw material enters the second chamber 32 through the communication flow channel. The number of the groove 113 can be one or multiple, and preferably, in order to accelerate the mixing speed of the first raw material and the second raw material, the number of the groove 113 is at least two, and further, in order to facilitate the first raw material to move to the second chamber 32 uniformly, all the grooves 113 are uniformly and spacedly distributed along the circumference of the container 11. In addition, in order to reduce the existence of the dead angle of the inner wall of the container 11, the inner wall of the container 11 is in a cylindrical shape.

[0100] In an embodiment, as shown in Figure 1 and Figure 3 , the atomization device 100 further comprises an atomization chip 4, the atomization chip 4 is provided with a plurality of atomization flow channels 41, and the atomization chip 4 is located outside the sealing plug 12. When the liquid pressure of the liquid flowing out of the first end 111 reaches a preset value, the liquid is processed by the atomization chip 4 to form atomized fine particles and then escapes. In this way, during the mixing of the first raw material and the second raw material, if the sealing plug 12 is separated from the first end 111, the liquid cannot pass through the atomization flow channels 41 of the atomization chip 4 because the liquid pressure in the second chamber 32 does not reach the preset value at this time, so as to avoid atomization while mixing raw materials and cause material waste.

[0101] Further, as shown in Figure 2 , the sealing plug 12 is arranged in the port of the first end 111, and the sealing plug 12 is in interference fit with the inner wall of the first end 111 to ensure sealing.

[0102] Further, as shown in Figure 2 and Figure 3 , when the sealing plug 12 is separated from the first end 111, the sealing plug 12 is in abutment with the atomization chip 4 under the extrusion of the mixed material.

[0103] In an embodiment, as shown in Figure 3 , Figure 7 and Figure 8 , the sealing plug 12 comprises a sealing plug body 121 and four protruding structures 122, and the protruding structures 122 are arranged on the side of the sealing plug body 121 facing the atomization chip 4. As shown in Figure 1 and Figure 3 , when the sealing plug 12 is separated from the first end 111, the protruding structures 122 are used to form a first gap 51 between the sealing plug body 121 and the atomization chip 4, so as to avoid the sealing plug body 121 covering the atomization flow channels 41 of the atomization chip 4, and ensure that the mixed material in the second chamber 32 can smoothly flow to the atomization flow channels 41 of the atomization chip 4 through the first gap 51 for smooth atomization. Of course, the number of protruding structures 122 can also be one, two, three or even more.

[0104] Further, as shown in Figure 1 , Figure 3 , Figure 6 and Figure 13 , the atomization device 100 further comprises a pen barrel 61 for the user to hold, and the container assembly 1 and the piston assembly 2 are arranged in the pen barrel 61. The pen barrel 61 is provided with a first hollow column 611 and a second hollow column 612 connected in sequence along the first direction a, and the atomization chip 4 is installed in the second hollow column 612. As shown in Figure 3As shown, when the sealing plug 12 is detached from the first end 111, the sealing plug body 121 is located in the first hollow column 611, a second gap 52 is formed between the circumferential wall of the sealing plug body 121 and the inner wall of the first hollow column 611, and the second chamber 32, the second gap 52, the first gap 51 and the atomization flow channel 41 are sequentially communicated, so that when atomization is performed, the mixture in the second chamber 32 flows to the atomization flow channel 41 through the second gap 52 and the first gap 51 in sequence, and atomization is realized. In addition, the second hollow column 612 of the present scheme can also be adapted for use with a mouthpiece assembly (not shown in the figure) for the user to inhale through the mouth or the nose, so that more atomized fine particles can be delivered into the human body, avoiding waste of atomized fine particles due to excessive exposure.

[0105] Further, as shown in Figure 3 , the transverse spatial size of the first hollow column 611 is greater than that of the second hollow column 612, and when the sealing plug 12 is detached from the first end 111, the protruding structure 122 abuts against the end face 6121 of the second hollow column 612 towards the first hollow column 611, so as to reduce or avoid direct contact of the protruding structure 122 with the surface of the atomization chip 4, that is, the coverage of the protruding structure 122 on the atomization flow channel 41 can be reduced or completely avoided, and interference of the protruding structure 122 with the atomization work is avoided.

[0106] In an embodiment, as shown in Figure 7 and Figure 8 , the sealing plug body 121 comprises a first column body 1211 and a second column body 1212 connected in sequence along the first direction a, the first column body 1211 is in the shape of a circular truncated cone, and the first column body 1211 gradually expands along the first direction a, the second column body 1212 is in the shape of a circular cylinder, and the outer diameter of the second column body 1212 is equal to the maximum outer diameter of the first column body 1211, so that the connection between the first column body 1211 and the second column body 1212 is smooth, and of course, the outer diameter of the second column body 1212 can also be greater than the maximum outer diameter of the first column body 1211. As shown in Figure 2 and Figure 7 , when the sealing plug 12 is assembled in the port of the first end 111, the outer wall of the second column body 1212 is in interference fit with the inner wall of the first end 111. As shown in Figure 3 and Figure 7 , when the sealing plug 12 is detached from the first end 111, the circumferential outer wall of the first column body 1211 is provided in the shape of an inclined surface, which is beneficial to improve the flow of the mixture in the second chamber 32 into the second gap 52, and further beneficial to accelerate the atomization speed.

[0107] Further, as shown in Figure 7 and Figure 8 , the protruding structure 122 partially protrudes outward from the circumferential wall of the second column body 1212, which is beneficial to increase the transverse size of the protruding structure 122, as shown inFigure 3 As shown, the contact area between the protruding structure 122 and the end face 6121 of the first hollow column 611 can be increased. Figure 2 As shown, when the sealing plug 12 is assembled into the port of the first end 111, the protruding structure 122 is pressed and deformed by the inner wall of the first end 111 to ensure that the sealing plug 12 can be smoothly clamped into the first end 111 of the container 11.

[0108] In an embodiment, since the mixture contacts the sealing plug 12 during the atomization process of the atomization device 100, in order to ensure the health safety of the atomization inhalation, as shown in Figure 2 As shown, the container assembly 1 further comprises a bottle cap 13, which is arranged on the first end 111 of the container 11 to cover the sealing plug 12, preventing the sealing plug 12 from being contaminated during the storage or transportation of the container assembly 1. Before assembling the container assembly 1 into the pen barrel 61, the bottle cap 13 is removed first, and then the assembly is performed.

[0109] In an embodiment, as shown in Figure 1 、 Figure 6 and Figure 13 The atomization device 100 further comprises a pen cap 62, which is connected to the first end of the pen barrel 61. As shown in Figure 1 and Figure 3 The pen cap 62 is provided with a sealing column 621, which is inserted into the second hollow column 612 and is in interference fit with the second hollow column 612 to seal the first end of the pen barrel 61. When the atomization device 100 is not needed to be used, the pen cap 62 is used to seal the first end of the pen barrel 61 to avoid the contamination of the atomization chip 4. When the atomization device 100 needs to be used, the pen cap 62 is removed.

[0110] Specifically, the connection mode of the pen cap 62 and the pen barrel 61 includes but is not limited to snap connection, magnetic attraction connection or screw connection. In a specific mode, as shown in Figure 11 and Figure 12As shown, the cap 62 is provided with two buckling grooves 622 which are symmetrically distributed, the outer wall of the first end of the barrel 61 is provided with two buckling protrusions 613 which are one-to-one corresponding to the buckling grooves 622, the cap 62 is sleeved on the outer periphery of the first end of the barrel 61 and is one-to-one buckled with the buckling protrusions 613 and the buckling grooves 622 to realize detachable connection of the two. Further, in order to reduce the buckling difficulty of the buckling protrusions 613 and the buckling grooves 622, the inner wall of the cap 62 is provided with two sliding grooves 623 which are one-to-one corresponding to the buckling grooves 622, the matched sliding grooves 623 and buckling grooves 622 are sequentially arranged and communicated with each other along the circumference of the cap 62, when assembling the cap 62 and the barrel 61, the buckling protrusions 613 are first inserted into the corresponding sliding grooves 623, then the cap 62 or the barrel 61 is rotated to make the buckling protrusions 613 and the buckling grooves 622 buckled with each other, in this way, the cap 62 and the barrel 61 can be easily buckled. Of course, the number of the buckling protrusions 613, the buckling grooves 622 and the sliding grooves 623 is not limited to two, but can be three, four or even more, as long as they are one-to-one corresponding.

[0111] Further, as shown in Figure 1 、 Figure 6 and Figure 13 , the atomization device 100 further comprises a cap 63 which is connected to the second end of the barrel 61 to seal the second end of the barrel 61, the cap 63, the barrel 61 and the cap 62 jointly constitute the outer contour structure of the atomization device 100.

[0112] Specifically, the connection mode of the cap 63 and the barrel 61 includes but is not limited to screwing, buckling connection or magnetic attraction connection, in a specific embodiment, as shown in Figure 10 and Figure 11 , the inner wall of the cap 63 is provided with an inner thread 633, the outer wall of the second end of the barrel 61 is provided with an outer thread 614, the cap 63 and the barrel 61 are connected by screwing of the inner thread 633 and the outer thread 614 and have good sealing performance.

[0113] In an embodiment, as shown in Figure 6 、 Figure 11 and Figure 13As shown, the pen barrel 61 is further provided with a mounting hole 616, and the atomization device 100 further comprises a viewing window 9, which is made of transparent plastic or transparent glass. The viewing window 9 is mounted in the mounting hole 616 and is located opposite to the container 11, so as to view the remaining amount of the mixture in the container 11. When the mixture in the container 11 is used up, the pen cap 63 is first removed, the container 11 is taken out by pulling the piston rod 21, the pen barrel 61 is inverted, the sealing plug 12 is taken out, then the piston rod 21 is separated from the container 11, and the container assembly 1 is replaced, so as to realize repeated use of the atomization device 100, save use cost, and facilitate operation.

[0114] In an embodiment, as shown in Figure 1 and Figure 6 , the atomization device 100 further comprises a retaining member 7, which is in a cylindrical shape and is used to retain the container 11 to prevent the container 11 from rotating. The retaining member 7 is mounted in the pen barrel 61. Compared with the scheme that the container 11 is directly assembled with the pen barrel 61, the scheme can reduce the machining requirement of the pen barrel 61. Specifically, the outer wall of the retaining member 7 is in interference fit with the inner wall of the pen barrel 61, and the inner wall of the retaining member 7 is in interference fit with the outer wall of the container 11, so as to fix the container 11.

[0115] Further, as shown in Figure 1 , the retaining member 7 has a size in the first direction a smaller than that of the container 11, which is beneficial to lightweight design of the atomization device 100. Further, when the second end 112 of the container 11 is placed upward, the retaining member 7 is located at the lower part of the pen barrel 61, which is beneficial to stability of the center of gravity of the atomization device 100.

[0116] In an embodiment, as shown in Figure 1 and Figure 6 , the atomization device 100 further comprises a trigger assembly 8, which comprises an operating mechanism 81 and a pawl 82. The operating mechanism 81 is movably mounted on the pen barrel 61, and the pawl 82 is rotatably connected to the operating mechanism 81. The piston rod 21 is provided with a ratchet structure 211 having a plurality of tooth portions arranged in sequence along the axial direction of the piston rod 21. The pawl 82 is used to engage with the ratchet structure 211 provided on the piston rod 21.

[0117] As shown in Figure 1 , Figure 4 and Figure 5As shown, when the operating mechanism 81 is moved in the first direction a under an external force, the pawl 82 pushes the ratchet structure 211 to move the piston rod 21 in the first direction a, and the piston rod 21 pushes the first piston 22 and the second piston 23 to trigger atomization. That is, the user can trigger atomization by operating the operating mechanism 81, and the operation is convenient. When the operating mechanism 81 is moved in the second direction b, the piston rod 21 does not move together, the first direction a is opposite to the second direction b, and the first direction a and the second direction b are two opposite directions in the axial direction of the piston rod 21. In this way, the one-way path length of the operating mechanism 81 does not need to be set too large. When the operating mechanism 81 is moved in the first direction a to the limit position of the one-way path, atomization is realized once, at this time, the operating mechanism 81 cannot continue to move in the first direction a, and then the operating mechanism 81 can be driven to move in the second direction b to reset, at this time, the pawl 82 engages with another tooth portion of the ratchet structure 211, and the pawl 82 can continue to drive the piston rod 21 to move in the first direction a to realize the next atomization. After the atomization device 100 is used repeatedly for multiple times, the mixture in the container 11 can be used completely or as much as possible.

[0118] Further, as shown in Figure 1 , the operating mechanism 81 is provided with a limiting structure 8121 located at one end of the pawl 82 away from the container 11. In this way, when the pawl 82 is moved in the first direction a, the pawl 82 can stably engage with the ratchet structure 211 under the abutment of the limiting structure 8121, and the limiting structure 8121 is used to limit the rotation angle of the pawl 82, so that the pawl 82 can engage with the ratchet structure 211 when the operating mechanism 81 is moved in the first direction a under an external force.

[0119] In an embodiment, as shown in Figure 1 , Figure 6 and Figure 13 , the operating mechanism 81 comprises an operating element 811 and a connecting element 812. The operating element 811 is at least partially located outside the pen barrel 61 for the user to operate. The connecting element 812 is located inside the pen barrel 61 and connected with the operating element 811, and the pawl 82 is rotatably connected with the connecting element 812 through a pivot shaft 83. Preferably, the operating element 811 is a push button, which is simple in structure and can be triggered by the user by pushing the operating element 811.

[0120] Specifically, as shown in Figure 1 and Figure 11As shown, the operation element 811 is provided with a connecting block 8111, the pen barrel 61 is provided with a long hole 615, the connecting block 8111 passes through the long hole 615 and extends into the pen barrel 61, and the connecting block 8111 is connected with the adapter element 812, so that the operation element 811 and the adapter element 812 can move synchronously. In addition, the hole wall of the long hole 615 can limit the moving direction of the connecting block 8111, so as to ensure that the operation element 811 can only move along the first direction a or the second direction b.

[0121] In an embodiment, as shown in Figure 9 and Figure 10 , the pen cap 63 is provided with a limiting groove 631, and the piston rod 21 is provided with a limiting protrusion 212, the limiting groove 631 and the limiting protrusion 212 are connected, so as to limit the rotation of the piston rod 21 relative to the pen cap 63, so that the piston rod 21 can only move along the first direction a.

[0122] Further, as shown in Figure 1 , Figure 9 and Figure 10 , the pen cap 63 is further provided with a containing groove 632; when the atomization device 100 is in the initial state, part of the tooth portions of the ratchet structure 211 are located in the containing groove 632, so that the piston rod 21 can be provided with as many tooth portions as possible, so as to ensure that the operation element 811 can be kept in the engaged state with the ratchet structure 211 after reset, and meanwhile, the internal space of the pen barrel 61 is not excessively occupied, so as to cause the pen barrel 61 to be too long. With the movement of the piston rod 21 along the first direction a, the tooth portions located in the containing groove 632 gradually leave the containing groove 632.

[0123] Further, when assembling the atomization device 100, the following steps are included:

[0124] 1) After the piston rod 21 and the first piston 22 are assembled (for example, the two are connected with each other through the clamping portion 213 and the clamping groove 221), the pen cap 63 is pre-assembled to form a first pre-assembly assembly;

[0125] 2) Remove the bottle cap 13 of the container assembly 1, assemble the pen barrel 61 and the pen cap 62 (for example, through the buckling protrusion 613 and the buckling groove 622), and pre-assemble the container assembly 1 to form a second pre-assembly assembly;

[0126] 3) Assembling the first pre-assembled component with the second pre-assembled component, inserting the piston rod 21 and the first piston 22 into the container 11, and rotating the cap 63 to screw the cap 63 with the barrel 61; it should be understood that, in this step, in order to prevent the first material in the first chamber 31 from spilling out of the second end of the container 11, the second end of the container 11 is placed upward, then the assembly is performed, and when the piston rod 21 and the first piston 22 are inserted into the container 11, the insertion of the first piston 22 first causes the first material to move from the first chamber 31 to the second chamber 32, in the process, the ratchet structure 211 is located above the pawl 82, and when the first pre-assembled component is assembled with the second pre-assembled component, the pawl 82 is engaged with the first tooth portion below the ratchet structure 211;

[0127] 4) Assembling the cap 63 with the barrel 61 to complete the assembly of the atomization device 100.

[0128] It should be understood that the above embodiments are exemplary and are not intended to include all possible implementations included in the claims. Various modifications and changes can also be made on the basis of the above embodiments without departing from the scope of the present disclosure. Similarly, any combination of the technical features of the above embodiments can also be made to form additional embodiments of the present application that can not be explicitly described. Therefore, the above embodiments only express several implementations of the present application, and do not limit the protection scope of the present application.

Claims

1. An atomising device characterised in that, The atomization device comprises: a container assembly comprising a container and a sealing plug, the container having a first end in an open state and a second end, and the sealing plug being used to seal the first end; a piston assembly comprising a piston rod, a first piston and a second piston, the first piston and the second piston being sequentially arranged in the container in a first direction, and one end of the piston rod being located in the container and linked with the first piston; wherein, in the container cavity, a side of the second piston away from the sealing plug forms a first chamber, and a second chamber is formed between the second piston and the sealing plug; the first chamber is used to contain a first raw material, and the second chamber is used to contain a second raw material; when the piston rod pushes the first piston to move relative to the second piston in the first direction, the first raw material enters the second chamber and mixes with the second raw material to form a mixed material, and in this process, the sealing plug is separated from the first end under the extrusion of the mixed material; the atomization device further comprises an atomization chip located outside the sealing plug; when the liquid pressure of the liquid flowing out of the first end reaches a preset value, the liquid is processed by the atomization chip to form atomized fine particles and then escapes; and if the sealing plug is separated from the first end during the mixing of the first raw material and the second raw material, the liquid pressure of the liquid flowing out of the first end does not reach the preset value.

2. The atomization device of claim 1, wherein, In the process of assembling the piston rod in the container, the piston rod pushes the first piston to move relative to the second piston in the first direction, so that the first raw material enters the second chamber.

3. The atomization device of claim 1, wherein, When the first piston moves in the first direction to abut against the second piston, the first raw material completely enters the second chamber.

4. The atomization device of claim 1, wherein, The first raw material is in a liquid state, and the second raw material is in a lyophilized powder state or a liquid state.

5. The atomization device of claim 4, wherein, The second raw material is a nanobody in a lyophilized powder state.

6. The atomization device of claim 1, wherein, The sealing plug is a rubber plug.

7. The atomizing device according to any one of claims 1 to 6, characterized in that An inner wall of the container is provided with a groove, and a communication flow channel is formed between the groove and an outer wall of the second piston, and the first chamber and the second chamber are communicated through the communication flow channel. Under the extrusion of the first piston or the action of the air pressure of the first chamber, the first raw material enters the second chamber through the communication flow channel.

8. The atomizing device according to any one of claims 1 to 6, wherein The sealing plug is arranged in a port of the first end and is in interference fit with the port.

9. The atomization device of claim 8, wherein, When the sealing plug is separated from the first end, the sealing plug abuts against the atomization chip under the extrusion of the mixed material.

10. The atomization device of claim 9, wherein, The sealing plug comprises a sealing plug body and a plurality of protruding structures arranged on a side of the sealing plug body facing the atomization chip. When the sealing plug is separated from the first end, the protruding structures are used to form a first gap between the sealing plug body and the atomization chip, and the mixed material in the second chamber flows to an atomization flow channel of the atomization chip through the first gap.

11. The atomization device of claim 10, wherein, The atomization device further comprises a pen barrel provided with a first hollow column and a second hollow column connected in sequence in a first direction; the container assembly and the piston assembly are arranged in the pen barrel, and the atomization chip is mounted in the second hollow column. When the sealing plug is separated from the first end, the sealing plug body is located in the first hollow column, a second gap is formed between the circumferential wall of the sealing plug body and the inner wall of the first hollow column, and the second cavity, the second gap, the first gap and the atomization flow channel are sequentially communicated.

12. The atomization device of claim 11, wherein, The transverse spatial size of the first hollow column is greater than the transverse spatial size of the second hollow column; when the sealing plug is separated from the first end, the protruding structure abuts against the end face of the second hollow column to reduce or completely avoid covering of the atomization flow channel by the protruding structure.

13. The atomization device of claim 11, wherein, The sealing plug body comprises a first column body and a second column body connected in sequence in a first direction; The first column body is frustoconical, and gradually expands in the first direction; The second column body is cylindrical, and the outer diameter of the second column body is greater than or equal to the maximum outer diameter of the first column body; when the sealing plug is assembled in the port of the first end, the outer wall of the second column body is in interference fit with the inner wall of the first end.

14. The atomization device of claim 13, wherein, The protruding structure is partially convex outward from the circumferential wall of the second column body; When the sealing plug is assembled in the port of the first end, the protruding structure is extruded and deformed by the inner wall of the first end.

15. The atomization device of claim 11, wherein, The atomization device further comprises a pen cap connected to the first end of the pen barrel; The pen cap is provided with a sealing column inserted into the second hollow column and in interference fit with the second hollow column to seal the first end of the pen barrel.

16. The atomization device of claim 15, wherein, The atomization device further comprises a pen cap connected to the second end of the pen barrel to seal the second end of the pen barrel.

17. The atomization device of claim 11, wherein, The atomization device further comprises a retaining member for retaining the container and mounted in the pen barrel.

18. The atomizing device of any one of claims 1-6, wherein, The atomization device further comprises a pen barrel and a trigger assembly, and the container assembly and the piston assembly are arranged in the pen barrel; the trigger assembly comprises: an operating mechanism movably mounted on the pen barrel; a pawl rotatably connected to the operating mechanism, the pawl being used to engage with a ratchet structure provided on the piston rod; wherein when the operating mechanism moves in a first direction under an external force, the pawl pushes the ratchet structure to make the piston rod move in the first direction, and the piston rod pushes the first piston and the second piston to move to trigger atomization; when the operating mechanism moves in a second direction, the piston rod does not move together, and the first direction is opposite to the second direction.

19. The atomization device of claim 18, wherein, The operating mechanism is provided with a limiting structure for limiting the rotation angle of the pawl to enable the pawl to remain engaged with the ratchet structure during movement of the operating mechanism in the first direction.

20. The atomization device of claim 18, wherein, The operating mechanism comprises: an operating element at least partially located outside the pen barrel; an adapter element located inside the pen barrel and connected to the operating element, and the pawl is rotatably connected to the adapter element.

21. The atomization device of claim 18, wherein, The atomization device further comprises a pen cap connected to the second end of the pen barrel to seal the second end of the pen barrel; The pen cap is provided with a limiting slot, and the piston rod is provided with a limiting protrusion; the limiting slot and the limiting protrusion are clamped to limit the rotation of the piston rod relative to the pen cap.

22. The atomization device of claim 21, wherein, The pen cap is further provided with a containing slot; when the atomization device is in the initial state, the ratchet structure is partially located in the containing slot.

23. The atomization device of claim 22, wherein, The atomization device further comprises a pen cover connected to the first end of the pen barrel. When the atomization device is assembled, the piston rod is assembled with the first piston to form a first pre-assembly assembly, and the pen barrel is assembled with the pen cover to form a second pre-assembly assembly; then, the first pre-assembly assembly and the second pre-assembly assembly are assembled, and when the assembly is completed, the pawl is engaged with the ratchet structure.

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