Method for establishing rat radiodermatitis model

By setting up a detailed model group in the rat radiodermatitis model and using a 6MeV electronic accelerator for precise radiation irradiation, the problems of dose inconsistency and group settings in the existing models were solved, and the operability of the experiment and the reliability of the results were improved, providing an effective method to in-depth study of the mechanism of radiodermatitis and evaluate the treatment plan.

CN119701226APending Publication Date: 2025-03-28CHINA INST FOR RADIATION PROTECTION
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Patent Information

Application Number
CN202411804461.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-10
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The existing rat radiodermatitis model has problems such as inconsistent irradiation dose, insufficient model group settings, insufficient observation period, inconsistent ray types and energy, irregular protective measures, and single or incomplete evaluation indicators, which affect the accuracy and reliability of experimental results.

Method used

A method for establishing a rat radiodermatitis model was adopted, including setting up a control group, a low-dose group, a medium-dose group, a high-dose group and a sham irradiation group, using a 6MeV electronic accelerator for precisely controlled radiation irradiation, combining a lead box design to ensure consistency of the radiation area, and long-term observation and pathological examination were performed.

Benefits of technology

By accurately controlling radiation dose and rationally setting the model group, the operability of the experiment and the reliability of the results are greatly improved, and a reliable experimental basis is provided to study the mechanism of radiodermatitis and evaluate the treatment plan.

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Abstract

The invention discloses a method for establishing a rat radiodermatitis model. The method comprises the following steps: S1, setting a control group, a low-dose group, a medium-dose group, a high-dose group and a false irradiation group; the control group is not irradiated, and the skin state of the rats under the condition that the rats are not damaged by radiation is observed; the total irradiation dose of the low-dose group is 35Gy; the total irradiation dose of the medium dose group is 40Gy; the total irradiation dose of the high-dose group is 45Gy; s2, selecting rats, shaving and cleaning radiation parts of the rats, and performing anesthesia treatment on the rats; s3, a 6MeV electron accelerator is adopted for radiation irradiation, the irradiation time of a low-dose group is 5.83 minutes, the irradiation time of a medium-dose group is 6.67 minutes, and the irradiation time of a high-dose group is 7.5 minutes; s4, after irradiation is completed, the rats are removed and transferred into a clean cage, the reaction of the rats after irradiation is observed, and the initial conditions of skin injuries including erythema and swelling are recorded; experiments should regularly record the health condition of the rat.
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