Interpretation device of immunochromatography analyzer

Abstract

The application provides an immunochromatography analysis interpretation device, the device comprises a shell, the shell is internally provided with a main control board, the main control board comprises a display area and an acquisition area; the sensor is arranged in the acquisition area of the main control board; the display unit is arranged in the display area of the main control board, and the display unit and the sensor are located on the two sides of the main control board respectively; a power supply unit that supplies power to the optical unit and the display unit; the reset switch can control the opening and closing of the whole device and can control the working mode of the sensor; the light guide base can be in butt joint with and fixed to the main control board, and three open holes are formed in the surface of the light guide base and are respectively a reset switch hole, a light source assembly hole and a sensor slit; due to the existence of the sensor slit, the sensing area of the sensor is limited, so that an approximate scanning working process can be realized under a proper sampling frequency, and the NC membrane reaction area of the reagent card is completely scanned.

Description

Technical Field

[0001] The present application relates to the technical field of immunochromatographic analysis, and in particular to an immunochromatographic analyzer reading device. Background Art

[0002] Colloidal gold carries a negative charge in a weakly alkaline environment and can form a strong bond with the positively charged groups of protein molecules. Since this bond is an electrostatic bond, it does not affect the biological properties of the protein. In addition to binding with proteins, colloidal gold can also bind to many other biological macromolecules, such as SPA, PHA, ConA, etc. Based on some physical properties of colloidal gold, such as high electron density, particle size, shape and color reaction, plus the immune and biological properties of the conjugate, colloidal gold is widely used in immunology, histology, pathology and cell biology. Colloidal gold labeling is essentially a coating process in which macromolecules such as proteins are adsorbed onto the surface of colloidal gold particles. The adsorption mechanism may be that the negative charge on the surface of the colloidal gold particles forms a strong bond with the positively charged groups of the protein due to electrostatic adsorption. The immunogold labeling technique mainly utilizes the high electron density of gold particles. Dark brown particles can be seen under a microscope at the gold-labeled protein binding site. When these markers are aggregated in large quantities at the corresponding ligands, red or pink spots can be seen with the naked eye. Therefore, it is used in qualitative or semi-quantitative rapid immunoassay methods. This reaction can also be amplified by the deposition of silver particles, which is called immunogold and silver staining. Colloidal gold technology has the advantages of convenience, specific sensitivity, strong stability, no need for special equipment and reagents, and intuitive result judgment. Therefore, it is particularly suitable for grassroots inspection personnel, large-scale testing, and large-scale censuses, etc., and has huge development potential and broad application prospects.

[0003] The principle of immunochromatography is to first fix specific antibodies to a certain zone of the nitrocellulose membrane. When one end of the dry nitrocellulose is immersed in the sample (urine or serum), the sample will move forward along the membrane due to capillary action. When it moves to the area where the antibody is fixed, the corresponding antigen in the sample will specifically bind to the antibody. If immunocolloidal gold or immunoenzyme staining is used, the area can show a certain color, thereby achieving specific immunodiagnosis.

[0004] When light shines on metal, the electrical properties of the material change. This kind of light-induced electrical phenomenon is collectively called the photoelectric effect. The photoelectric effect is divided into photoelectron emission, photoconductivity effect and barrier photoelectric effect, also known as the photovoltaic effect. The former phenomenon occurs on the surface of an object, also known as the external photoelectric effect. The latter two phenomena occur inside an object, called the internal photoelectric effect.

[0005] Photoelectric sensors generally consist of two parts: processing pathways and processing elements. The basic principle is to convert the measured changes into changes in light signals based on the photoelectric effect, and then further convert non-electrical signals into electrical signals with the help of photoelectric elements. The photoelectric effect refers to irradiating an object with light, which can be regarded as a series of photons with a certain energy bombarding the object. At this time, the photon energy is transferred to the electron, and the entire energy of a photon is absorbed by an electron at one time. After the electron obtains the energy transferred by the photon, its state will change, so that the object irradiated with light will produce a corresponding electrical effect. The photoelectric detection method has the advantages of high precision, fast response, non-contact, etc., and it can measure many parameters. The sensor has a simple structure and flexible and diverse forms. Therefore, photoelectric sensors are widely used in detection and control. Summary of the invention

[0006] In order to solve the problems in the prior art of unstable test results and low ability of the equipment to recognize low values, while avoiding the excessive size of the immunochromatographic analysis device, the present application provides a compact immunochromatographic analyzer reading device using a photoelectric sensor.

[0007] The technical solution of this application is as follows:

[0008] 1. An immunochromatographic analyzer reading device, comprising:

[0009] A housing is provided with:

[0010] A main control board, the main control board comprising a display area and a collection area;

[0011] A sensor, which is a static scanning sensor and is arranged in a collection area of ​​the main control board;

[0012] A display unit, wherein the display unit is arranged in a display area of ​​the main control board,

[0013] The display unit and the sensor are respectively located on two sides of the main control board;

[0014] A light guide base, which can be buckled with the main control board on the collection area;

[0015] A light source component, which is arranged on the collection area of ​​the main control board to provide a light signal for the sensor;

[0016] A reset switch, which can control the opening and closing of the immunochromatographic analyzer reading device and the working mode of the sensor;

[0017] A power supply unit provides power to the device.

[0018] 2. The device according to item 1, wherein the surface of the light guide base is provided with three openings, namely a reset switch hole, a light source assembly hole and a sensor slit.

[0019] 3. The device according to item 1, further comprising a reagent card control mechanism, wherein the reagent card control mechanism comprises an external button, an internal lever, a clamping member, a movable member and a spring, wherein the movable member is abutted against the lower portion of the shell through the spring, and the clamping member is arranged on both sides of the movable member.

[0020] 4. The device according to item 3, wherein one end of the internal lever abuts against the clamping member, and the other end is fixed to the lower part of the shell together with the external button.

[0021] 5. The device according to item 2, wherein the light-guiding base is made of light-proof plastic.

[0022] 6. The device according to item 1 further comprises a central control unit, which is arranged on a main control board.

[0023] 7. The device according to item 1, wherein the sensor, light source assembly and reset switch are arranged in a straight line in the vertical direction on the center line of the main control board.

[0024] 8. The device according to items 1-7, wherein, after the light guide base is buckled with the main control board, the reset switch passes through the reset switch hole so that the reset switch is exposed and protrudes from the surface of the light guide base, and the light source assembly passes through the light source assembly hole so that the light source assembly is exposed and protrudes from the surface of the light guide base.

[0025] 9. The device according to items 1-8, wherein, when a reagent card is inserted into the reagent card control mechanism, an external force presses an external button of the reagent card control mechanism to eject the reagent card in the reagent card control mechanism, and during the reagent card ejection process, the collection area of ​​the sensor is displaced, and at a sampling frequency of 1 MHz, a signal can be collected for every 0.001 to 0.01 mm displacement.

[0026] 10. The device according to item 1, wherein the display unit comprises a display screen and is electrically connected to a central control unit and a power supply unit.

[0027] The beneficial effects of this application are:

[0028] (1) The immunochromatographic analysis and interpretation device provided in the present application uses a photoelectric sensor, which can improve the sensitivity of the device to low values ​​and achieve a high recognition ability for low values;

[0029] (2) The light source and sensor of the device are small in size and are all arranged on a printed circuit board, which is low in cost and small in assembly error, and is convenient for users to use in any scenario;

[0030] (3) The device has a false touch judgment function. After the reagent card is inserted, the light source is turned on and the sensor will collect signals several times. If an unused reagent card is inserted, the sensor will present a specific signal feature. If it is a false touch, the signal feature is abnormal and the system will exit the waiting state.

[0031] (4) When the reagent card is ejected, the reset switch is triggered again, and the system begins to continuously collect sensor signals. Since the sensor window is very narrow and the sensing area is limited, an approximate "scanning" working process can be achieved at an appropriate sampling frequency;

[0032] (5) The continuous reading system can read the printed information of the reagent card, interpret the sample results, and read the barcode containing the reagent kit information printed on the tongue area of ​​the reagent card, thereby completing the overall entry of relevant information;

[0033] (6) Under the requirements of limited space, low cost and high sensitivity, the performance of dynamic detection is achieved by using a static detection scheme. The present application can complete highly sensitive immunochromatographic quantitative detection in a limited space, and adopts a technical solution combining dynamic and static methods to achieve low cost while ensuring the reliability of the results. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The accompanying drawings are used to better understand the present application and do not constitute an improper limitation on the present application.

[0035] Figure 1 An exploded diagram of the immunochromatographic analyzer reading device provided in this application;

[0036] Figure 2 A schematic diagram of the main control board of the immunochromatographic analyzer reading device provided in this application;

[0037] Figure 3 A schematic diagram of the main control board and light guide base assembly of the immunochromatographic analyzer reading device provided in this application;

[0038] Figure 4 Schematic diagram of the reagent card control mechanism of the immunochromatographic analyzer reading device provided in this application;

[0039] Figure 5 A schematic diagram of the partial structure of the immunochromatographic analyzer reading device provided in this application;

[0040] Figure 6 The waveform diagram obtained by using the immunochromatographic analyzer reading device provided in the present application and the corresponding relationship between the waveform diagram and the reagent card.

[0041] Description of reference numerals:

[0042] 10-main control board, 101-power supply unit, 102-display unit, 103-light guide base, 105-light source assembly, 106-sensor, 108-central control unit, 109-reset switch, 201-external button, 202-internal lever, 203-clamping part, 204-spring, 205-moving part, 206-spring, 301-reagent card sample adding area, 302-reagent card hollow area, 1031-reset switch hole, 1032-light source assembly hole, 1033-sensor slit. DETAILED DESCRIPTION

[0043] The specific embodiments of the present application will be described in more detail below with reference to the accompanying drawings. Although the specific embodiments of the present application are shown in the accompanying drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present application and to fully convey the scope of the present application to those skilled in the art.

[0044] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the difference in the functions of the components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" is an open term, so it should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the implementation of the present application, but the description is based on the general principles of the specification and is not used to limit the scope of the present application. The scope of protection of the present application shall be determined by the attached claims.

[0045] To facilitate the understanding of the specific scheme of the present application, further explanation will be given below with reference to several specific embodiments with reference to the accompanying drawings, and each drawing does not constitute a limitation to the present application.

[0046] In the specification of the present application, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0047] In the specification of this application, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meaning of the above terms in this application based on the specific content of the technical solution.

[0048] In this application specification, the “vertical direction” is defined as Figure 1 The arrow in the figure indicates the direction.

[0049] In this application specification, "sampling" refers to sensor data collection, which is the process of converting the physical quantities sensed by the sensor into digital signals and transmitting them to a computer or other device for processing and analysis through a specific interface. Its principles mainly include two aspects: signal conversion and data transmission.

[0050] In this application specification, "scanning" means sampling the target object point by point and line by line in units of instantaneous field of view by relying on detection elements or scanning mirrors to obtain electromagnetic radiation characteristic information of the target object and form an image of a certain spectral band; in this specification, the "scanning" method is specifically "push-broom" scanning.

[0051] In a specific embodiment of the present application, an immunochromatographic analyzer reading device includes a housing, a main control board 10 , a sensor 106 , a display unit 102 , a light guide base 103 , a light source assembly 105 , and a power supply unit 101 .

[0052] In a specific embodiment of the present application, there is no specific limitation on the size of the shell, which must at least be able to accommodate the main control board 10 , sensor 106 , display unit 102 , light guide base 103 , light source assembly 105 , and power supply unit 101 .

[0053] In a specific embodiment of the present application, the material of the shell is not specifically limited, and any material considered suitable for the device shell by those skilled in the art can be used, such as acrylonitrile-butadiene-styrene copolymer (ABS), polycarbonate, polyoxymethylene, polytetrafluoroethylene, polypropylene, polyvinyl chloride, polyphenylene sulfide, nylon, silicone, aluminum alloy, carbon steel, stainless steel, copper, etc.

[0054] In a specific implementation of the present application, the main control board 10 is an irregular thin plate.

[0055] In a specific implementation of the present application, the sensor 106 is a photoelectric sensor, such as a phototube, a photoresistor, a photodiode, a phototransistor, a photosensitive diode, etc.

[0056] In a specific implementation of the present application, the scanning mode of the sensor 106 is dynamic scanning.

[0057] In a specific implementation of the present application, the display unit 102 is a small display screen, and its size can be adaptively adjusted based on the size of the main control board 10 .

[0058] In a specific implementation of the present application, the light guide base 103 is preferably rectangular.

[0059] In a specific implementation of the present application, the light source assembly is preferably an LED lamp.

[0060] In a specific implementation of the present application, the power supply unit 101 is a small power supply component, such as a power supply chip MAX1632, MAX1635, MAX1631, MAX1634, MAX1904, MAX1632, etc.

[0061] In a specific embodiment of the present application, the immunochromatographic analyzer reading device is further provided with a reagent card control mechanism for controlling the entry, exit and fixation of the reagent card.

[0062] In a specific embodiment of the present application, the reagent card control mechanism includes an external button 201 , an internal lever 202 , a clamping member 203 , a spring 204 , a moving member 205 and a spring 206 .

[0063] In a specific implementation manner of the present application, the moving member 205 is a cuboid, and may also be a cylinder, a cone, a triangular pyramid, a triangular pyramid, etc.

[0064] In a specific implementation of the present application, a slot is provided at the lower portion of the housing to accommodate the moving member 205 to enter and exit.

[0065] In a specific implementation of the present application, the middle portion of the clamping member 203 is fixed to the lower portion of the shell, one end is hook-shaped, and the other side is fixed to the spring 204 and abuts against the outer wall of the lower shell slot.

[0066] In a specific embodiment of the present application, the internal lever 202 is in the shape of an elongated strip, one end of which is against the non-hook-shaped end of the clamp 203, and an external button 201 is provided on the outer side of the middle part of the internal lever 202, and the external button 201 and the internal lever 202 are both fixed to the lower part of the shell.

[0067] In a specific implementation of the present application, the main control board 10 includes a display area and a collection area, and a sensor 106, a light source assembly 105 and a reset switch 109 are arranged in the collection area.

[0068] In a specific implementation of the present application, the sensor 106 is a static scanning sensor.

[0069] In a specific implementation of the present application, three openings are provided on the surface of the light guide base 103 , namely a reset switch hole 1031 , a light source assembly hole 1032 , and a sensor slit 1033 .

[0070] In a specific embodiment of the present application, after the light guide base 103 is buckled with the main control board 10, the reset switch 109, the light source assembly 105 and the sensor 106 pass through the reset switch hole 1031, the light source assembly hole 1032 and the sensor slit 1033 respectively, so that the reset switch 109, the light source assembly 105 and the sensor 106 are exposed and protrude from the surface of the light guide base 103.

[0071] In a specific implementation of the present application, the light guide base 103 is fastened and fixed to the main control board 10 to isolate the sensor 106 from the external light source.

[0072] In a specific implementation of the present application, the sensor slit 1033 can greatly improve the signal quality.

[0073] In a specific implementation of the present application, the central control unit 108 has a false touch judgment function.

[0074] In a specific implementation of the present application, after the reagent card is fully inserted, the reset switch 109 stays in the hollow area 302 of the reagent card.

[0075] In a specific embodiment of the present application, after the reagent card is inserted, the system will enter the waiting state, the light source assembly 105 will light up, and the sensor 106 will collect signals several times. If an unused reagent card is inserted, the sensor 106 will present a specific signal characteristic, and the system will remain in the waiting state; if it is an accidental touch, the signal characteristic is abnormal, and the central control unit 108 will exit the waiting state.

[0076] In a specific embodiment of the present application, when the central control unit 108 is in a state to be detected, the light source assembly 105 and the sensor 106 will continue to work, and the signal intensity of the hollow area 302 of the reagent card corresponding to the sensor 106 will significantly decrease after the sample is added.

[0077] In a specific embodiment of the present application, after adding the sample, the sensor 106 will transmit the sensed signal to the central control unit 108, and the central control unit 108 will start timing after sensing the sample addition signal. When the preset reaction time is reached, the system will issue an audible and visual prompt.

[0078] In a specific embodiment of the present application, when the central control unit 108 starts timing, the sensor 106 will continue to sample. When the response time is reached, the system arranges the data collected by the sensor 106 into a multidimensional array and calculates the data based on factors such as time, intensity, and physical location.

[0079] In a specific embodiment of the present application, when the reaction is completed, the reagent card is ejected after squeezing the external button 201 of the reagent card control device 20. The reset switch will be triggered again during the ejection process. At this time, the central control unit 108 starts to continuously collect signals from the sensor 106. Due to the presence of the sensor slit 1033, the sensing area is limited. Therefore, at an appropriate sampling frequency, an approximate "scanning" working process can be achieved, thereby completely scanning the NC membrane reaction area of ​​the reagent card.

[0080] In a specific embodiment of the present application, when the reagent card is ejected, the collection area of ​​the sensor 106 will be displaced. Under an appropriate sampling frequency, a signal can be collected for every 0.001-0.01mm displacement. For example, a signal can be collected every 0.001mm, 0.002mm, 0.003mm, 0.004mm, 0.005mm, 0.006mm, 0.007mm, 0.008mm, 0.009mm, and 0.01mm, which is equivalent to placing a sensor every 0.001-0.01mm, and a very high-quality NC membrane absorbance signal can be obtained.

[0081] In a specific implementation of the present application, the information obtained during the scanning process is transmitted back to the central control unit 108 for processing and then used to correct the sampling results.

[0082] In a specific embodiment of the present application, during the scanning process, the barcode pre-printed on the reagent card tongue carrying the reagent card information can also be read, and the signal characteristics of the barcode can also be used for post-sampling data correction.

[0083] In a specific embodiment of the present application, after the reagent card is popped out, the central control unit 108 combines the information of the sampling and scanning processes to finally obtain the concentration of the analyte and displays it on the display unit 102. The user can view the results through the display unit 102 and store the test results in the central control unit 108.

[0084] In a specific implementation of the present application, after the reagent card is ejected, if the reset switch 109 is not triggered within a period of time, the system will enter a standby sleep state.

[0085] Example

[0086] like Figure 1 to Figure 3 As shown in the figure, in a specific embodiment of the present application, an immunochromatographic analyzer reading device includes a housing, a main control board 10, a sensor 106, a display unit 102, a central control unit 108, a power supply unit 101, a light guide base 103, and a reagent card control device; the housing is divided into an upper housing and a lower housing. The main control board 10 includes a display area and a collection area. The display area is a relatively large rectangular area on the main control board 10. A display unit 102 is arranged in the display area on the upper surface of the main control board 10. The display unit 102 is composed of a display screen. The display unit 102 can display the instrument, product information and test results on the screen. The display area on the lower surface of the main control board 10 is provided with a power supply unit 101, which provides stable power for the operation of the equipment. The other areas on the main control board 10 except the display area are the collection area. At the end of the collection area, the sensor 106, the light source assembly 105 and the reset switch 109 are distributed on the center line of the main control board 10 in a straight line in the vertical direction. The reset switch 109 is used to control the closing and disconnection of the power supply in the device, and the light source assembly is used to provide a stable light source for the reagent card. The light guide base 103 is composed of light-proof plastic. The surface of the light guide base 103 is provided with three openings, namely, the reset switch hole 1031, the light source assembly hole 1032 and the sensor slit 1033. When the light guide base 103 is buckled with the main control board 10, the reset switch 109, the light source assembly 105 and the sensor 106 pass through the reset switch hole 1031, the light source assembly hole 1032 and the sensor slit 1033, and the sensor 106, the light source assembly 105 and the reset switch 109 are reinforced, and the reset switch 109, the light source assembly 105 and the sensor 106 are exposed and protrude from the surface of the light guide base. The central control unit 108 is arranged in the middle position of the main control board 10. The central control unit 108 is a microcomputer system, including a microprocessor, a system program memory, a user memory, a timer, a counter, etc. The system program is used to perform signal processing and other tasks. The timer and counter can provide accurate trigger conditions for program execution and support the program execution detection, timing, communication, display and other tasks.

[0087] like Figure 4As shown in the figure, in a specific embodiment of the present application, the reagent card control mechanism includes an external button 201, an internal lever 202, a clamping member 203, a spring 204, a moving member 205 and a spring 206. A rectangular area with an opening on one side surrounded by plastic is arranged in the center of the lower shell. The end of the moving member 205 abuts against the spring 206 and the two are fixed in the rectangular area of ​​the lower shell. The end of the moving member 205 that does not contact the spring is consistent with the direction of the opening of the rectangular area. The clamping member 203 is a lever style, fixed in the middle, one side is hook-shaped, and the other side is fixed to the spring 204 and abuts against the outer wall of the rectangular area. There are two clamping members 203, which are respectively fixed on both sides of the rectangular area where the moving member 205 is located. The external button 201 and the internal lever 202 of the reagent card control mechanism are respectively arranged and fixed on both sides of the clamping member 203. The outer wall of the shell where the external button 201 is located is hollowed out, and the external button can be directly touched from the outside of the shell during operation. On the inner wall of the bottom surface of the lower housing, a sliding track is provided from the end of the moving member 205 to the end of the lower housing in the same direction, and the width of the sliding track can accommodate the reagent card of conventional size to pass through. The main control board 10 is placed in the lower layer of the reagent card control mechanism after being combined with the light guide base 103, and the projection area of ​​the main control board 10 acquisition area coincides with the sliding track. The housing surface located just above the display unit 102 is provided with a rectangular hollowing to avoid affecting the information on the normal observation display unit 102 screen. The upper and lower housings are buckled together by a snap-on mode to form a complete housing and contain all the above components therein, forming a complete immunochromatographic analyzer reading device.

[0088] like Figure 5 As shown in the figure, in a specific embodiment of the present application, the working principle of an immunochromatographic analyzer reading device is as follows:

[0089] After the reagent card to be tested is inserted from the entrance, the moving part 205 of the reagent card control mechanism is subjected to force and moves backward with the reagent card, and the clamping part 203 positions and clamps the reagent card, and the spring 206 is in a compressed state at this time, and the reagent card triggers the reset switch 109 at the same time, so that the power supply unit 101 provides stable power for the equipment operation, and the central control unit 108 is started, and the display unit 102 is lit, and the power-on self-test program is carried out simultaneously, and the screen will flash the "water drop" symbol after completion, prompting the user to add samples. At this time, the central control unit 108 makes the light source assembly on the light source plate 104 emit light, and the reagent card sample adding area 302 is added. After sensing the chromatography reaction, enter the detection mode, and the "clock" symbol flashes on the screen at this time, prompting the user to have started to react. The timer of the central control unit 108 is started, and the timing time is the preset time in the program. During the period, the sensor will continue to work, and the system arranges the data collected by the sensor 106 into a multidimensional array, and calculates the data by factors such as time, intensity, and physical position. The sensor 106 statically scans to determine whether the reagent card has reached the detection endpoint. When the reaction endpoint is reached, the system emits an audible and visual prompt. At this time, the external button 201 of the reagent card control mechanism is manually pressed. The external button 201 is compressed by force, driving the internal lever 202 to squeeze the spring 204 that is against the clamp 203. The spring 204 is deformed by force, causing the clamp 203 to open outward, and the hook of the clamp 203 is separated from the reagent card. The moving part 205 is ejected forward under the action of its tail spring 206, and the reagent card in front of it is ejected at the same time. The reset switch will be triggered again during the ejection process. At this time, the central control unit 108 starts to continuously collect signals from the sensor 106, and the collection area of ​​the sensor 106 is displaced, reaching a signal collected for every 0.001mm to 0.01mm displacement, thereby completely scanning the NC membrane reaction area of ​​the reagent card to obtain complete NC membrane features, such as Figure 6 As shown, the peak calculation is performed according to the data characteristics of the waveform to obtain the peak data of the C / T line. Combined with the preset calibration curve, the concentration of the object to be tested is finally obtained and output to the screen.

[0090] At the same time, the barcode of the reagent card information carried on the reagent card tongue is scanned, and the information obtained from the above continuous sampling process is transmitted back to the central control unit 108 to correct the previous test results, and finally the concentration of the analyte is obtained and displayed on the display unit 102. The user can view the result at this time through the display unit 102. At the same time, the reagent card information carried on the reagent card tongue is also displayed on the display unit 102. When no operation is performed for a period of time, the system will turn off the screen and enter the power saving mode.

[0091] The relationship between the collected waveform signal, signal strength and signal position, and the corresponding relationship between the waveform and the reagent card are as follows: Figure 6 shown.

[0092] A technical solution and / or a combination of multiple technical solutions in the above embodiments of the present application has the following beneficial effects:

[0093] (1) The immunochromatographic analysis and interpretation device provided in the present application uses a photoelectric sensor, which can improve the sensitivity of the device to low values ​​and achieve a high recognition ability for low values;

[0094] (2) The light source and sensor of the device are small in size and are all arranged on a printed circuit board, which is low in cost and small in assembly error, and is convenient for users to use in any scenario;

[0095] (3) The device has a false touch judgment function. After the reagent card is inserted, the light source is turned on and the sensor will collect signals several times. If an unused reagent card is inserted, the sensor will present a specific signal feature. If it is a false touch, the signal feature is abnormal and the system will exit the waiting state.

[0096] (4) When the reagent card is ejected, the reset switch is triggered again, and the system begins to continuously collect sensor signals. Since the sensor window is very narrow and the sensing area is limited, an approximate "scanning" working process can be achieved at an appropriate sampling frequency;

[0097] (5) The continuous reading system can read the printed information of the reagent card, interpret the sample results, and read the barcode containing the reagent kit information printed on the tongue area of ​​the reagent card, thereby completing the overall entry of relevant information;

[0098] (6) Under the requirements of limited space, low cost and high sensitivity, the performance of dynamic detection is achieved by using a static detection scheme. The present application can complete highly sensitive immunochromatographic quantitative detection in a limited space, and adopts a technical solution combining dynamic and static methods to achieve low cost while ensuring the reliability of the results.

[0099] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. An immunochromatographic analyzer reading device, wherein: include: A housing is provided with: A main control board, the main control board comprising a display area and a collection area; A sensor, which is a static scanning sensor and is arranged in a collection area of ​​the main control board; A display unit, wherein the display unit is arranged in a display area of ​​the main control board, The display unit and the sensor are respectively located on two sides of the main control board; A light guide base, which can be buckled with the main control board on the collection area; A light source component, which is arranged on the collection area of ​​the main control board to provide a light signal for the sensor; A reset switch, which can control the opening and closing of the immunochromatographic analyzer reading device and the working mode of the sensor; A power supply unit provides power to the device.

2. The device according to claim 1, wherein: The surface of the light guide base is provided with three openings, namely a reset switch hole, a light source assembly hole and a sensor slit.

3. The device according to claim 1, wherein: It also includes a reagent card control mechanism, which includes an external button, an internal lever, a clamping member, a moving member and a spring. The moving member is in contact with the lower part of the shell through the spring, and the clamping member is arranged on both sides of the moving member.

4. The device according to claim 3, wherein: One end of the internal lever abuts against the clamping member, and the other end is fixed to the lower part of the shell together with the external button.

5. The device according to claim 2, wherein: The material of the light-guiding base is light-proof plastic.

6. The device according to claim 1, wherein: It also includes a central control unit, which is arranged on the main control board.

7. The device according to claim 1, wherein: The sensor, light source assembly and reset switch are arranged in a straight line in the vertical direction on the center line of the main control board.

8. The device according to claims 1-7, wherein: After the light guide base is buckled with the main control board, the reset switch passes through the reset switch hole so that the reset switch is exposed and protrudes from the surface of the light guide base, and the light source assembly passes through the light source assembly hole so that the light source assembly is exposed and protrudes from the surface of the light guide base.

9. The device according to claims 1-8, wherein: When the reagent card is inserted into the reagent card control mechanism, an external force presses the external button of the reagent card control mechanism to eject the reagent card in the reagent card control mechanism. During the reagent card ejection process, the collection area of ​​the sensor is displaced. At a sampling frequency of 1 MHz, a signal can be collected for every 0.001 to 0.01 mm displacement.

10. The device according to claim 1, wherein: The display unit includes a display screen and is electrically connected to the central control unit and the power supply unit.

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