Mouthwash formula for relieving oral submucosal fibrosis

Abstract

The invention relates to a remission mouth wash formula specially aiming at oral submucosal fibrosis (OSF), which is mainly applied to the field of oral care. OSF is an oral mucosa chronic progressive disease caused by betel nut chewing, smoking and other factors, and existing mouthwash has limitation in relieving. The formula of the mouthwash provided by the invention comprises xylitol, honey, vitamin C, vitamin B12, deionized water and a compound consisting of extracts of various herbaceous plants such as gordon euryale seed shells, honeysuckle, chrysanthemum, dandelion, fructus forsythiae, radix polygonati officinalis, clove, eupatorium, selfheal, liquorice and Chinese olive. In addition, curcumin and panax notoginseng saponins are added and account for 1%-5% of the total mass, preferably 2%. According to the formula of the mouthwash, natural herbaceous plant extracts with anti-inflammation and sterilization effects are added, so that the oral ulcer symptom is relieved, and meanwhile, the human immune system is regulated to prevent relapse. The preparation method is simple and easy to implement, is specially designed for relieving OSF, and aims to overcome the defects of current relieving means.

Description

Technical Field

[0001] The invention relates to the field of mouthwash formulations, and in particular to a mouthwash formulation for alleviating oral submucosal fibrosis. Background Art

[0002] Oral submucous fibrosis is a chronic, progressive oral mucosal disease with a potential for malignant transformation. Its pathological characteristics are mainly manifested by fibrosis of the oral submucosal layer, which causes the oral mucosa to become hard and lose elasticity, thereby affecting oral function. OSF patients often experience symptoms such as limited mouth opening, difficulty swallowing, and decreased taste, which seriously affect their quality of life.

[0003] The main pathogenic factors of OSF include smoking and betel quid chewing. The synergistic effect of smoking and betel quid chewing may aggravate the development of OSF.

[0004] At present, the relief methods for OSF mainly include drug relief, surgical relief and physical relief. However, these relief methods have many limitations. Drug relief has limited effect and may bring side effects; surgical relief is traumatic, takes a long time to recover, and may affect oral function; physical relief lacks specificity and is difficult to achieve the purpose of radical cure. Therefore, it is of great significance for OSF patients to develop a safe, effective and convenient relief method.

[0005] As an important part of oral care, mouthwash has the functions of cleaning the oral cavity, sterilizing and reducing inflammation, and preventing oral diseases. However, existing mouthwashes have limited effect in relieving OSF. Therefore, it is of great significance to develop a mouthwash specifically for relieving OSF.

[0006] In order to solve the above problems, the applicant proposes a mouthwash formula for alleviating oral submucosal fibrosis. Summary of the invention

[0007] The object of the present invention is to provide a mouthwash formula for alleviating oral submucosal fibrosis, so as to solve the problems in the prior art.

[0008] To achieve the above object, the present invention provides the following technical solution: a mouthwash formula for alleviating oral submucosal fibrosis, comprising the following ingredients:

[0009] Xylitol: 4-6 parts;

[0010] Honey: 3-7 portions;

[0011] Vitamin C: 2-4 servings;

[0012] Vitamin B12: 3-5 servings;

[0013] Deionized water: 50 parts;

[0014] The herbal plant extract comprises the following raw materials by weight: 12-15 parts of Euryale ferox shell, 7-10 parts of honeysuckle, 6-9 parts of chrysanthemum, 8-10 parts of dandelion, 9-12 parts of forsythia, 8-11 parts of polygonatum, 6-9 parts of clove, 7-10 parts of eupatorium, 5-10 parts of selfheal, 5-8 parts of liquorice, 4-7 parts of green fruit, and curcumin and notoginseng total saponin respectively accounting for 1%-5% of the total mass, and other commonly used formula ingredients for mouthwash, wherein the proportion of the other commonly used formula ingredients for mouthwash is 0.1-0.5%.

[0015] Optionally, the curcumin and Panax notoginseng total saponins each account for 2% of the total mass.

[0016] Optionally, the herbal plant extract is prepared by the following method: after mixing the raw materials in proportion by weight, extracting by water distillation, alcohol extraction or supercritical fluid extraction.

[0017] Optionally, the mouthwash formula further comprises a preservative, a flavoring agent and / or a coloring agent, and the content of each of the preservatives, a flavoring agent and / or a coloring agent is independently 0.01%-0.1% of the total mass of the mouthwash.

[0018] Optionally, the mouthwash formulation is used to alleviate oral submucous fibrosis caused by betel nut chewing or smoking.

[0019] The method for preparing the mouthwash formulation according to any one of claims 1 to 4, comprising the following steps:

[0020] a. Mix the xylitol, honey, vitamin C, vitamin B12 and deionized water;

[0021] b. Add the herbal extract to the mixture and stir evenly;

[0022] c. Add preservatives, flavorings and / or coloring agents as needed and stir again;

[0023] d. filling, sealing and sterilizing the obtained mixture to obtain the mouthwash.

[0024] Optionally, in step d, the sterilization treatment adopts high-temperature steam sterilization or ultraviolet sterilization.

[0025] The mouthwash prepared using the mouthwash formula according to any one of claims 1 to 4 is used to alleviate oral submucosal fibrosis.

[0026] Beneficial effects:

[0027] Anti-inflammatory and bactericidal: The various active ingredients in herbal plant extracts have significant anti-inflammatory and bactericidal effects, and can effectively inhibit the growth and reproduction of harmful microorganisms in the oral cavity;

[0028] Promote oral mucosal repair: Vitamin C, vitamin B12 and other nutrients can promote the growth and repair of oral mucosal cells and accelerate the recovery of oral mucosa;

[0029] Relieve oral symptoms: Ingredients such as xylitol and honey can relieve symptoms such as dry mouth and pain, and improve patient comfort;

[0030] Preventing recurrence: Natural compounds in herbal extracts have the function of regulating the human immune system and can reduce the recurrence rate of OSF. DETAILED DESCRIPTION

[0031] The present invention can be embodied in many different forms of implementation, and the protection scope of the present invention is not limited to the implementations mentioned herein.

[0032] In view of the shortcomings of the prior art, the present invention provides a mouthwash formula for relieving oral submucous fibrosis. The mouthwash formula has significant anti-inflammatory, bactericidal, oral mucosal repair promoting effects and the like by scientifically mixing multiple active ingredients, and can effectively relieve OSF.

[0033] Mouthwash formula ingredients

[0034] The mouthwash formulation of the present invention comprises the following ingredients (by mass percentage):

[0035] Xylitol: 4-6 parts;

[0036] Honey: 3-7 portions;

[0037] Vitamin C: 2-4 servings;

[0038] Vitamin B12: 3-5 servings;

[0039] Deionized water: 50 parts;

[0040] The herbal plant extract comprises the following raw materials by weight: 12-15 parts of Euryale ferox shell, 7-10 parts of honeysuckle, 6-9 parts of chrysanthemum, 8-10 parts of dandelion, 9-12 parts of forsythia, 8-11 parts of polygonatum, 6-9 parts of clove, 7-10 parts of eupatorium, 5-10 parts of selfheal, 5-8 parts of liquorice, 4-7 parts of green fruit, and curcumin and notoginseng total saponins account for 1%-5% of the total mass, preferably 2%;

[0041] Other commonly used ingredients in mouthwashes, such as preservatives, flavoring agents, colorants, etc., are supplemented at a content of 0.1-0.5% (calculated as a percentage of the total mass of the mouthwash) to ensure the overall stability and use effect of the mouthwash.

[0042] Preparation of herbal extracts

[0043] In the mouthwash formula of the present invention, the herbal plant extract is one of the key ingredients. The extract is prepared by the following method: the above-mentioned herbal plant raw materials are mixed in weight proportions, and then extracted by water distillation, alcohol extraction or supercritical fluid extraction. Among them, the water distillation method is suitable for extracting volatile components, the alcohol extraction method is suitable for extracting non-volatile components, and the supercritical fluid extraction method has the advantages of high efficiency and environmental protection. Which extraction method is specifically selected can be determined according to actual needs and extraction efficiency.

[0044] Preparation method of mouthwash formula

[0045] The preparation method of the mouthwash formula of the present invention is simple and easy to implement, comprising the following steps:

[0046] a. Mix xylitol, honey, vitamin C, vitamin B12 and deionized water to form a base solution;

[0047] b. Add the prepared herbal extract to the above base solution and stir evenly;

[0048] c. Add preservatives, flavorings and / or coloring agents as needed and stir again;

[0049] d. Filling, sealing and sterilizing the obtained mixture to obtain the final product.

[0050] During the filling, sealing and sterilization process, automated production lines can be used to improve production efficiency and product quality. At the same time, to ensure the safety and effectiveness of the product, each batch of products should be quality tested and controlled.

[0051] Example 1

[0052] Preparation of herbal extracts

[0053] After 12 parts of Euryale ferox shell, 7 parts of honeysuckle, 6 parts of chrysanthemum, 8 parts of dandelion, 9 parts of forsythia, 8 parts of polygonatum, 6 parts of cloves, 7 parts of perilla, 5 parts of selfheal, 5 parts of liquorice, and 4 parts of green fruit are mixed evenly, the mixture is extracted by water distillation. During the extraction process, parameters such as temperature, pressure and extraction time are controlled to obtain the best extraction effect. After the extraction is completed, the extract is concentrated, dried, and the like to obtain a herbal plant extract.

[0054] Preparation of mouthwash

[0055] After 4 parts of xylitol, 3 parts of honey, 2 parts of vitamin C, 3 parts of vitamin B12 and 50 parts of deionized water are mixed evenly, the above prepared herbal extract is added and stirred evenly. Then, appropriate amounts of preservatives (such as sodium benzoate), flavoring agents (such as peppermint oil) and colorants (such as food coloring) are added as needed, and stirred evenly again. Finally, the obtained mixture is filled, sealed and sterilized with high-temperature steam to obtain the final product.

[0056] Efficacy verification

[0057] The prepared mouthwash was clinically tested to observe its effect on OSF patients. The results showed that oral mucosal inflammation was significantly reduced, the degree of mouth opening restriction was improved, and no obvious side effects occurred in patients using the mouthwash.

[0058] Example 2

[0059] Preparation of herbal extracts

[0060] After 15 parts of Euryale ferox shell, 10 parts of honeysuckle, 9 parts of chrysanthemum, 10 parts of dandelion, 12 parts of forsythia, 11 parts of polygonatum, 9 parts of cloves, 10 parts of eupatorium, 10 parts of selfheal, 8 parts of liquorice, 7 parts of green fruit and 2% of curcumin and total saponin of Panax notoginseng by weight are uniformly mixed, and then extracted by alcohol extraction. During the extraction process, a suitable solvent and extraction conditions are selected to obtain the best extraction effect. After the extraction is completed, the extract is concentrated, dried, etc. to obtain a herbal plant extract.

[0061] Preparation of mouthwash

[0062] After 6 parts of xylitol, 7 parts of honey, 4 parts of vitamin C, 25 parts of vitamin B1 and 50 parts of deionized water are mixed evenly, the above prepared herbal extract is added and stirred evenly. Then, appropriate amounts of preservatives (such as potassium sorbate), flavoring agents (such as lemon oil) and colorants (such as blueberry pigment) are added as needed, and stirred evenly again. Finally, the obtained mixture is filled, sealed and sterilized by ultraviolet light to obtain the final product.

[0063] Efficacy verification

[0064] The prepared mouthwash was clinically tested to observe its effect on OSF patients. The results showed that the degree of oral mucosal fibrosis was reduced, oral function was improved, and the quality of life of patients was improved.

[0065] The present invention provides a mouthwash formula for relieving oral submucous fibrosis, which has significant anti-inflammatory, bactericidal, and oral mucosal repair promoting effects by scientifically proportioning multiple active ingredients. Clinical trial results show that oral mucosal inflammation is significantly alleviated in patients using the mouthwash, the degree of mouth opening restriction is improved, and no obvious side effects occur. Therefore, the present invention has broad market prospects and application value.

[0066] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0067] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A mouthwash formula for alleviating oral submucous fibrosis, characterized in that: Includes the following ingredients: Xylitol: 4-6 parts; Honey: 3-7 portions; Vitamin C: 2-4 servings; Vitamin B12: 3-5 servings; Deionized water: 50 parts; The herbal plant extract comprises the following raw materials by weight: 12-15 parts of Euryale ferox shell, 7-10 parts of honeysuckle, 6-9 parts of chrysanthemum, 8-10 parts of dandelion, 9-12 parts of forsythia, 8-11 parts of polygonatum, 6-9 parts of clove, 7-10 parts of eupatorium, 5-10 parts of selfheal, 5-8 parts of liquorice, 4-7 parts of green fruit, and curcumin and notoginseng total saponin respectively accounting for 1%-5% of the total mass, and other commonly used formula ingredients for mouthwash, wherein the proportion of the other commonly used formula ingredients for mouthwash is 0.1-0.5%.

2. The mouthwash formulation according to claim 1, characterized in that The curcumin and Panax notoginseng total saponins account for 2% of the total mass respectively.

3. The mouthwash formulation according to claim 1, characterized in that The herbal plant extract is prepared by the following method: the raw materials are mixed in proportion by weight, and then extracted by water distillation, alcohol extraction or supercritical fluid extraction.

4. The mouthwash formulation according to claim 1 or 3, characterized in that: The mouthwash formula further comprises a preservative, a flavoring agent and / or a coloring agent, and the content of each of the preservatives, a flavoring agent and / or a coloring agent is independently 0.01% to 0.1% of the total weight of the mouthwash.

5. The mouthwash formulation according to any one of claims 1 to 4, characterized in that The mouthwash formula is used to alleviate oral submucous fibrosis caused by betel nut chewing or smoking.

6. The method for preparing a mouthwash formulation according to any one of claims 1 to 5, characterized in that: The following steps are involved: a. Mix the xylitol, honey, vitamin C, vitamin B12 and deionized water; b. Add the herbal extract to the mixture and stir evenly; c. Add preservatives, flavorings and / or coloring agents as needed and stir again; d. filling, sealing and sterilizing the obtained mixture to obtain the mouthwash.

7. The preparation method according to claim 5, characterized in that: In step d, the sterilization treatment adopts high temperature steam sterilization or ultraviolet sterilization.

8. A mouthwash prepared using the mouthwash formula according to any one of claims 1 to 4, characterized in that: Used to relieve oral submucous fibrosis.