Ciclopirox olamine composite medicine and application thereof in preparation of medicine for inhibiting scar

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AI technical title is built by Patsnap AI team. It summarizes the technical point description of the patent document.
By combining cipisamine with hyaluronic acid, a compound drug that can effectively inhibit scar hyperplasia at low concentrations was prepared, which solved the drug resistance and recurrence of existing scar treatment methods and achieved high therapeutic effects.

CN119746090APending Publication Date: 2025-04-04XIAMEN UNIV

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Patent Information

Application Number: CN202411988449.3
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2024-12-31
Publication Date: 2025-04-04

Application Information

Patent Timeline

31 Dec 2024

Application

CN202411988449.3

04 Apr 2025

Publication

CN119746090A

IPC: A61K47/55; A61K47/61; A61K31/728; A61K31/4418; A61P17/02

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Application Domain

Organic active ingredients Pharmaceutical non-active ingredients

Technology Topics

Ciclopirox OlaminePharmaceutical drug

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AI Technical Summary

Technical Problem

The existing scar treatment methods have drug resistance and recurrence problems, and the treatment effect is limited, and an effective method is urgently needed to improve the effect of scar treatment.

Method used

A complex drug that combines cipisamine with hyaluronic acid is prepared through ultrasonic dissolution technology to form a drug with a three-dimensional network structure, which can effectively inhibit the activity and migration ability of human keloid fibroblasts and vascular endothelial cells.

Benefits of technology

At low concentrations, cipistamine compound drugs can effectively inhibit the formation of proliferative scars, have high efficacy, and achieve drug retention and slow release through the formation of amide bonds, improving the therapeutic effect.

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Abstract

The invention provides a ciclopirox olamine composite medicine and application thereof in preparation of a medicine for inhibiting scars, and a preparation method of the ciclopirox olamine composite medicine comprises the following steps: S1, preparing a hyaluronic acid solution; and S2, adding the ciclopirox olamine into a hyaluronic acid solution, and carrying out ultrasonic dissolution to obtain the ciclopirox olamine composite medicine. The ciclopirox olamine composite medicine has the effect of inhibiting hypertrophic scars at lower concentration.

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