Microneedle applicator

Abstract

A microneedle applicator is provided. A microneedle applicator according to an embodiment of the present invention comprises: a microneedle array; the working part is arranged at the upper part of the microneedle array, so that a user applies an external force to insert the microneedles into the skin; the shell is used for accommodating the microneedle array and the working part; the first guide component is arranged at at least one position of the side part of the working component or at least one position of the side part of the linkage component of the working component; the second guide part is arranged at the position, corresponding to the first guide part, in the inner side face of the shell and meshed with the first guide part, and the first guide part slides so that the microneedle array can be prevented from rotating while the microneedle array can evenly and vertically descend through external force.

Description

[0001] Divisional application This application is a divisional application of the Chinese invention patent application with application number 2020800926390, invention name “Microneedle Applicator” and application date December 24, 2020. Technical Field

[0002] The present invention relates to a microneedle applicator, and in particular to a microneedle applicator which can uniformly insert microneedles into skin to ensure the reliability of drug delivery. Background Art

[0003] Biodegradable microneedles that are being researched and developed recently are usually inserted into the skin in two forms. That is, using a patch form and an applicator. Among them, in the case of the patch form, there are problems such as skin irritation caused by patch attachment and removal, reduction in microneedle insertion rate due to human body hair pressing the patch from the skin with human body hair to interfere with the close adhesion between the patch and the skin, and difficulty in attaching the patch to locations where the skin bends and moves, such as wrinkles or joints.

[0004] Furthermore, since the microneedle patch inserts the microneedles into the skin by the user's palm pressing force, the reliability of the microneedle insertion cannot be ensured depending on the user or the attachment site.

[0005] In particular, when the hardness of the microneedles is low, the insertion degree of the microneedles is not uniform depending on the position of the microneedle patch, thereby reducing the efficiency of drug delivery. Summary of the invention

[0006] Problems to be solved by the present invention In order to solve the above-mentioned problems in the prior art, an embodiment of the present invention provides a microneedle applicator that can quickly and effectively deliver drugs contained in microneedles to the skin.

[0007] Furthermore, an embodiment of the present invention provides a microneedle applicator that can ensure the reliability of stable insertion of the microneedles into the skin even when the hardness is low.

[0008] However, the problems to be solved by the present invention are not limited to the above-mentioned problems, and those skilled in the art can clearly understand other unmentioned problems through the following description.

[0009] Solutions for solving technical problems According to one aspect of the present invention for solving the problems described above, a microneedle applicator is provided, the microneedle applicator comprising: a microneedle array; a working component disposed on the upper part of the microneedle array to work so that a user applies an external force to insert the microneedles into the skin; a housing for accommodating the microneedle array and the working component; a first guide component disposed at at least one position on the side of the working component or at least one position on the side of a linkage component of the working component; and a second guide component disposed at a position corresponding to the first guide component in the inner side surface of the housing and engaged with the first guide component, the first guide component sliding to allow the microneedle array to be uniformly vertically lowered by the external force while preventing rotation or horizontal twisting.

[0010] In one embodiment, the hardness of the microneedle may be less than 0.5N.

[0011] In one embodiment, the microneedle array may include a drug, and the drug may include a local anesthetic drug selected from the group consisting of procaine, chloroprocaine, tetracaine, dibucaine, lidocaine, mepivacaine, benzocaine, bupivacaine, and a combination thereof.

[0012] In one embodiment, the first guide member may be arranged in a straight line along a vertical direction on a side of the working member.

[0013] In one embodiment, the second guide member may have different widths depending on positions on a horizontal cross section of the housing.

[0014] In one embodiment, the microneedle applicator may further include an adhesive layer disposed at the lower portion of the housing and attached to the skin, and the adhesive layer may have an opening in the center portion and may have a peeling portion with one side protruding outward.

[0015] In one embodiment, the housing may further include a locking component configured to support a lower end portion of the working component, and the working component may pressurize the microneedle array by the force of the locking component with the aid of the external force.

[0016] In one embodiment, the locking member may be provided to protrude from an upper end of an inner side surface of the housing toward a center side.

[0017] In one embodiment, the locking component can be vertically arranged in a rod shape on the inner side of the shell, the working component can be provided with a groove portion at a position corresponding to the locking component, and a support platform can be protruded toward the inner side of the groove portion, and the support platform can be broken by the external force.

[0018] In one embodiment, the locking member may be a groove portion provided at an upper end of an inner side surface of the housing, and the operating member may be provided with a protrusion portion inserted into the groove portion along the outer circumference.

[0019] In one embodiment, the microneedle applicator may further include a fluid layer disposed between the working component and the microneedle array, wherein the fluid layer may support the lower end of the working component, and the working component may pressurize the microneedle array by using the force of the external force to destroy the fluid layer.

[0020] In one embodiment, the fluid layer may include air, liquid and medicine.

[0021] In one embodiment, the microneedle applicator may further include a rubber band disposed between the working component and the microneedle array, and the working component may fix the rubber band on the upper side of the microneedle array so that the rubber band has elasticity, and when the working component releases the fixation of the rubber band with the help of the external force, the microneedle array may be pressurized by the elastic restoring force of the rubber band.

[0022] In one embodiment, the microneedle applicator may further include a leaf spring disposed between the working component and the microneedle array, and the working component may pressurize the microneedle array by elastically deforming the leaf spring with the help of the external force.

[0023] In one embodiment, a support body for supporting the microneedle array may be included between the leaf spring and the microneedle array.

[0024] In one embodiment, the microneedle array may be a microneedle patch.

[0025] According to another aspect of the present invention, a microneedle applicator is provided, which includes: a microneedle array; a working component, which is arranged on the upper part of the microneedle array to work, so that a user applies external force to insert the microneedles into the skin; a shell, which is used to accommodate the microneedle array and the working component; and a supporting component, which is arranged between the microneedle array and the working component and supports the working component with a specified supporting force, and the supporting force is released by means of the external force so that the working component pressurizes the microneedle array.

[0026] In one embodiment, the microneedle applicator may further include: a first guide component, which is arranged at at least one position on the side of the working component; and a second guide component, which is arranged at a position corresponding to the first guide component on the inner side surface of the shell and engages with the first guide component, and the first guide component slides to allow the microneedle array to drop vertically uniformly through the external force while preventing rotation or horizontal twisting.

[0027] In one embodiment, the supporting component may be a locking component protruding from the upper end of the inner side surface of the shell toward the center side, and the locking component may support the lower end of the working component. The working component can pressurize the microneedle array by using the external force to release the supporting force of the locking component.

[0028] In one embodiment, the supporting component may be a fluid layer, and the working component may pressurize the microneedle array by using the external force to release the supporting force of the fluid layer.

[0029] In one embodiment, the supporting force can be used to cause the skin in contact with the shell to expand outward.

[0030] According to another aspect of the present invention, a microneedle applicator is provided, which includes: a microneedle array; a working component, which is arranged on the upper part of the microneedle array to work so that a user applies external force to insert the microneedles into the skin; a shell, which is used to accommodate the microneedle array and the working component; and an elastic component, which is arranged between the microneedle array and the working component and pressurizes the microneedle array with the elastic force of the external force.

[0031] In one embodiment, the microneedle applicator may further include: a first guide component, which is arranged at at least one position on the side of the working component or at least one position on the side of the linkage component of the working component; and a second guide component, which is arranged at a position corresponding to the first guide component on the inner side surface of the shell and engages with the first guide component, and the first guide component slides to allow the microneedle array to drop vertically uniformly through the external force while preventing rotation or horizontal twisting.

[0032] In one embodiment, the elastic component may be a rubber band, and the working component may fix the rubber band on the upper side of the microneedle array so that the rubber band has elasticity. When the working component uses the external force to release the fixation of the rubber band, the microneedle array can be pressurized by the elastic restoring force of the rubber band.

[0033] In one embodiment, the elastic component may be a leaf spring. When the working component pressurizes the leaf spring with the help of the external force, the microneedle array may be pressurized by the elastic deformation force of the leaf spring.

[0034] According to another aspect of the present invention, a microneedle array applicator is provided, which includes: a microneedle array; a working part, which is arranged on the upper part of the microneedle array to work so that a user applies external force to insert the microneedles into the skin; and a shell, which is used to accommodate the microneedle array and the working part, the working part and the opening of the shell have the same shape, the working parts are staggered with each other at a specified angle so as to be supported by the opening edge of the shell, and the working part slides along the opening of the shell so that the support of the working part is released as the working part is rotated by the external force, so that the microneedle array can be evenly vertically descended while preventing rotation or horizontal twisting.

[0035] Effects of the Invention The microneedle applicator according to an embodiment of the present invention uses external force applied by a user to insert microneedles into the skin, thereby quickly and effectively delivering drugs contained in the microneedle array, thereby minimizing the user's discomfort.

[0036] Furthermore, the present invention has a vertical sliding guide, so that external force can be uniformly applied relative to the entire microneedle array, thereby ensuring insertion reliability even when the hardness of the microneedles is low, thereby improving drug delivery efficiency.

[0037] Furthermore, the present invention provides an external force with a simpler structure by setting a supporting component between the working component to which the user applies external force and the microneedle array, and provides external force to the microneedle array by releasing the supporting force of the supporting component, thereby saving manufacturing costs and improving price competitiveness.

[0038] Furthermore, the present invention arranges an elastic component on the upper part of the microneedle array and provides external force to the microneedle array through the elastic force of the elastic component, thereby requiring less force applied by the user, thereby improving the convenience of use.

[0039] Furthermore, the present invention contains a local anesthetic drug in the microneedle, so that when the local anesthetic drug is administered, anesthesia can be performed quickly and painlessly, and thus injection insertion can be performed painlessly. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 FIG. 4 is an exploded perspective view of a microneedle applicator according to a first embodiment of the present invention.

[0041] Figure 2 To show Figure 1 A horizontal cross-sectional view of another example of a guide component.

[0042] Figure 3 1 is a diagram for explaining the operation of the microneedle applicator according to the first embodiment of the present invention.

[0043] Figure 4 FIG. 4 is an exploded perspective view of a microneedle applicator according to a second embodiment of the present invention.

[0044] Figure 5 1 is a diagram for explaining the operation of the microneedle applicator according to the second embodiment of the present invention.

[0045] Figure 6 FIG. 4 is an exploded perspective view of a microneedle applicator according to a third embodiment of the present invention.

[0046] Figure 7 1 is a diagram for explaining the operation of the microneedle applicator according to the third embodiment of the present invention.

[0047] Figure 8 FIG. 4 is an exploded perspective view of a microneedle applicator according to a fourth embodiment of the present invention.

[0048] Fig. 9 1 and 2 are diagrams for explaining the operation of the microneedle applicator according to the fourth embodiment of the present invention.

[0049] Fig.10 1 is a diagram showing a microneedle applicator according to a fifth embodiment of the present invention. DETAILED DESCRIPTION

[0050] Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily implement the present invention. The present invention can be implemented in various forms and is not limited to the embodiments described herein. In order to clearly describe the present invention, parts not related to the description are omitted in the accompanying drawings, and the same or similar structural elements are marked with the same reference numerals throughout the specification.

[0051] The various embodiments of the present invention are provided to more completely describe the present invention to those skilled in the art to which the present invention belongs. The various embodiments described below can be modified in various forms, and the scope of the present invention is not limited to the following embodiments. On the contrary, these embodiments are provided to more comprehensively and improve the present invention and to fully convey the spirit of the present invention to those skilled in the art.

[0052] In these drawings, various variations in the shapes shown may be expected, for example, due to manufacturing techniques and / or tolerances. Therefore, the embodiments of the present invention should not be interpreted as limited to the specific shapes of the regions shown in this specification, for example, it is necessary to include shape variations caused by manufacturing.

[0053] The microneedle applicator of the present invention is used to effectively insert a microneedle array into the skin, and includes four embodiments. In this case, the microneedle applicator of the present invention provides additional external force to improve the reliability of microneedle insertion into the skin. As an example, the microneedle array can be a microneedle patch. And, the microneedle array can be a drug. In this case, the drug can be a drug for various uses as a biodegradable substance.

[0054] Among them, the first and second embodiments use a force corresponding to the supporting force through the supporting component to provide external force, the third and fourth embodiments use the elastic force through the elastic component to provide external force, and the fifth embodiment uses a force corresponding to the supporting force while omitting additional supporting components to provide external force.

[0055] Thus, the microneedle applicator of the present invention can stably insert microneedles into the skin, and thus can quickly and effectively deliver the drug contained in the microneedle array. Therefore, the user's discomfort caused by the use of the microneedle array can be minimized.

[0056] On the other hand, since the microneedles containing the local anesthetic drug have a low hardness, the microneedles may not be properly inserted into a part of the microneedle array compared to other parts. In other words, the microneedles may not be inserted uniformly in the microneedle array.

[0057] To this end, the present inventors conducted repeated in-depth research and experiments and found that the entire microneedle array needs to be kept evenly horizontal during the process of inserting the microneedles into the skin, thereby completing the present invention.

[0058] Herein, as an anesthetic drug for anesthetizing a body part, the local anesthetic drug is not particularly limited. As an example, the local anesthetic drug can be selected from the group consisting of procaine, chloroprocaine, tetracaine, dibucaine, lidocaine, mepivacaine, benzocaine, bupivacaine, and a combination thereof.

[0059] Therefore, the microneedle applicator of the present invention can perform anesthesia painlessly and quickly even when administering a local anesthetic drug itself, and can perform insertion of a hypodermic needle or a catheter painlessly under local anesthesia.

[0060] Figure 1 is an exploded perspective view of a microneedle applicator according to a first embodiment of the present invention, Figure 2 To show Figure 1 A horizontal cross-sectional view of another example of a guide member, Figure 3 1 is a diagram for explaining the operation of the microneedle applicator according to the first embodiment of the present invention.

[0061] Reference Figure 1 The microneedle applicator 10 according to the first embodiment of the present invention includes a guide component 11, a locking component 12, a working component 13, a housing 14 and a microneedle array 15.

[0062] The microneedle applicator 10 according to the first embodiment provides external force through a supporting member, and a locking member 12 is provided as the supporting member.

[0063] The guide member 11 includes a first guide member 11 a and a second guide member 11 b .

[0064] The first guide member 11a is provided at least one position on the side of the working member 13. As an example, the first guide member 11a can be provided in a protruding shape. On the contrary, the first guide member 11a can be provided in a recessed shape. In this case, the first guide member 11a can be provided at least three positions of the working member 13 to maintain the overall balance of the working member 13.

[0065] Furthermore, the first guide member 11a is provided in a straight line along the vertical direction on the side of the working member 13. As an example, the first guide member 11a may be provided in a "1" shape. That is, the first guide member 11a may be provided in a straight line from the upper surface to the lower surface of the working member 13. However, the first guide member 11a is not limited thereto and may have various shapes.

[0066] The second guide member 11b is disposed at a position corresponding to the first guide member 11a in the inner side surface of the housing 14. As an example, the second guide member 11b can be disposed concavely in a groove shape. On the contrary, the second guide member 11b can be disposed protrudingly in a protrusion shape. The second guide member 11b can be disposed in a vertical direction on the inner side surface of the housing 14. Furthermore, the second guide member 11b has a shape corresponding to the first guide member 11a and is inserted into the first guide member 11a.

[0067] In this case, the first guide member 11 a slides in the second guide member 11 b , and the microneedle array 15 is uniformly lowered by the external force applied by the user through the working member 13 .

[0068] Thus, the microneedle applicator 10 according to the first embodiment of the present invention can uniformly apply external force to the entire microneedle array 15. Therefore, even if the hardness of the microneedle is low, the microneedle can be uniformly inserted into the skin as a whole, so the insertion reliability of the microneedle can be ensured, thereby improving the drug delivery efficiency.

[0069] Herein, a specific description of the guide member 11 is described based on the first embodiment, but it is of course also applicable to the second to fourth embodiments.

[0070] Reference Figure 2 , the second guide member 11b' may have different widths depending on the position on the horizontal cross section of the housing 14'. That is, the second guide member 11b may have a greater width on the outside of the housing 14' than on the inside of the housing 14'. In this case, the first guide member 11a may have a shape corresponding to the second guide member 11b'.

[0071] As an example, the second guide member 11 b ′ and the first guide member 11 a may be in a “T” shape, but may be in various shapes and are not limited thereto.

[0072] As described above, by increasing the length of the facing surfaces of the second guide member 11b' and the first guide member 11a, the possibility of the first guide member 11a being separated from the second guide member 11b' can be minimized, thereby further improving the vertical descending characteristics of the operating member 13.

[0073] The locking member 12 supports the lower end of the working member 13. The locking member 12 can support the working member 13 with a predetermined supporting force. In this case, the locking member 12 can have a size that allows the working member 13 to pass through the locking member 12 by an external force.

[0074] As an example, Figure 1 As shown, the locking member 12 is arranged to protrude from the upper end of the inner side of the shell 14 to the center side. That is, the locking member 12 can be arranged in a locking shoulder shape. In this case, the locking member 12 can be formed along the inner peripheral surface of the shell 14 as a whole, or can be partially formed.

[0075] As another example, the locking member 12 may be vertically arranged in a rod shape inside the housing 14. In this case, the working member 13 is provided with a groove portion at a position corresponding to the locking member 12, and a support platform is provided protruding inside the groove portion. The support platform may be broken by an external force.

[0076] As another example, the locking member 12 may be a groove portion provided at the upper end of the inner side surface of the housing 14. In this case, the operating member 13 may have a protrusion portion along the outer circumference thereof that is inserted into the groove portion.

[0077] The working part 13 is disposed at the upper end of the housing 14 and at the upper part of the microneedle array 15. The working part 13 is operated so that the user applies external force to insert the microneedle into the skin. In this case, the working part 13 can release the supporting force of the locking part 12 by means of external force, so that the working part 13 pressurizes the microneedle array 15. As described above, the working part 13 can be operated by the user. In addition, the working part 13 can be disc-shaped.

[0078] In this case, the working member 13 may have a shape in which the center of the upper surface is concave, that is, a groove may be provided at the center of the upper surface of the working member 13 to guide the user's finger to be located at the center of the working member 13 .

[0079] Thus, the external force applied by the user can be uniformly applied to the entire working part 13. Therefore, the uniform lowering of the microneedle array 15 can be further ensured.

[0080] Furthermore, the operating member 13 can pressurize the microneedle array 15 with the force of the locking member 12 by the external force. In other words, the operating member 13 can pressurize the microneedle array 15 with the force of releasing the supporting force of the locking member 12 .

[0081] The housing 14 accommodates the working part 13 and the microneedle array 15. In this case, the working part 13 may be exposed to the outside from the upper end of the housing 14 so that it can be operated by the user. In addition, the housing 14 is cylindrical as a whole, and a hollow part may be provided in the center to accommodate the working part 13 and the microneedle array 15. That is, both the upper side and the lower side of the housing 14 may be open.

[0082] Furthermore, the housing 14 may have a specified height so that the working part 13 can be vertically lowered while preventing rotation or horizontal twisting to provide a force sufficient to insert the microneedles of the microneedle array 15 into the skin. The housing 14 may be configured to accommodate a surface perpendicular to the inner side of the working part 13 and the microneedle array 15.

[0083] The microneedle array 15 is provided with a plurality of microneedles containing drugs. The microneedles may be formed of a biodegradable substance. Also, as described above, the drug may be a local anesthetic drug, and of course may also include drugs for other purposes. In this case, the hardness of the microneedles may be 0.5N or less. Also, the microneedles may be formed into a suitable shape suitable for insertion into the skin. As an example, the microneedles may be conical, but are not limited thereto.

[0084] Also, the microneedle array 15 may be disposed at a lower portion of the working member 13. In this case, the microneedle array 15 may be attached to the working member 13 through an adhesive layer.

[0085] The microneedle applicator 10 may further include an adhesive layer 16 .

[0086] The adhesive layer 16 may be provided at the lower portion of the housing 14. Also, the lower surface of the adhesive layer 16 may be coated with an adhesive. Thus, the adhesive layer 16 may be attached to the skin. In this case, the adhesive layer 16 may be covered by a protective layer.

[0087] Furthermore, the adhesive layer 16 has an adhesive portion 16a on the upper surface along the periphery of the opening 16b. The adhesive portion 16a may have the same shape as the open lower surface of the housing 14. As an example, the adhesive portion 16a may be in a circular band shape.

[0088] Furthermore, the adhesive layer 16 may have an opening 16b at the center thereof. The opening 16b exposes the microneedle array 15 or the microneedles of the microneedle array 15 to the skin. The opening 16b may be circular, but is not particularly limited thereto.

[0089] Furthermore, the adhesive layer 16 has a peeling portion 16c protruding outward on one side. In this case, the peeling portion 16c may not be coated with adhesive so that the adhesive layer 16 can be easily separated from the skin. Furthermore, the peeling portion 16c can record a memo, such as the patient's condition, etc.

[0090] Below, refer to Figure 3 , describing the operation of the microneedle applicator 10.

[0091] Reference Figure 3 As shown in part (a), the protective layer on the lower surface of the adhesive layer 16 is removed, and the microneedle array 15 is ready to be applied to the skin. As shown in part (b), when the working part 13 is pushed by the user, the working part 13 is vertically lowered to the lower surface of the housing 14 by the locking part 12 while being prevented from rotating or twisting horizontally.

[0092] In this case, the side wall of the housing 14 can expand the skin in contact therewith outward by the supporting force of the locking member 12. Thus, the microneedle is inserted into the expanded skin, thereby improving the insertion efficiency and ensuring the insertion stability.

[0093] As shown in part (c), as the working part 13 descends, the microneedle array 15 comes into contact with the skin 1. In this case, the microneedles are inserted into the skin 1 by the force of the working part 13 through the locking part 12. As shown in part (d), the microneedle applicator 10 is removed. In this case, when the housing 14 is removed, only the adhesive layer 16 and the microneedle array 15 remain in the skin 1.

[0094] As shown in part (e), when the microneedle array 15 is removed, as shown in part (f), the skin 1 is exposed through the opening 16b in a state where the adhesive layer 16 is attached to the skin 1. In this case, in order to add a drug different from the microneedle array 15 or extract a body fluid, a hypodermic needle 2 is inserted into the exposed skin.

[0095] As described above, the microneedle applicator 10 according to the first embodiment of the present invention can provide an external force to the microneedle array 15 by releasing the supporting force of the locking member 12. Therefore, the microneedle applicator 10 according to the first embodiment of the present invention can provide an external force with a relatively simple structure, thereby saving manufacturing costs and improving price competitiveness.

[0096] Figure 4 is an exploded perspective view of a microneedle applicator according to a second embodiment of the present invention, Figure 5 1 is a diagram for explaining the operation of the microneedle applicator according to the second embodiment of the present invention.

[0097] Reference Figure 4 The microneedle applicator 20 according to the second embodiment of the present invention includes a fluid layer 22 , a working component 23 , a housing 24 and a microneedle array 25 .

[0098] The microneedle applicator 20 according to the second embodiment provides an external force by a supporting member, and has a fluid layer 22 as the supporting member.

[0099] The fluid layer 22 is disposed between the working part 23 and the microneedle array 25. The fluid layer 22 may be a capsule filled with any one of air, liquid and medicine. In this case, the capsule may be formed into an elliptical shape with a protruding center.

[0100] Furthermore, the fluid layer 22 supports the lower end of the working member 23. The fluid layer 22 can support the working member 23 with a predetermined supporting force. In this case, air can be injected into the fluid layer 22 with a pressure sufficient to maintain the supporting force.

[0101] Furthermore, the fluid layer 22 may be disposed on the upper side of the movable part 22a. The fluid layer 22 is disposed on the upper part of the movable part 22a, and the microneedle array 25 may be disposed on the lower part of the movable part 22a. In this case, while the movable part 22a supports the fluid layer 22, the working part 23 applies pressure as the fluid layer 22 is destroyed, thereby making the microneedle array 25 fall vertically while preventing rotation or horizontal twisting.

[0102] Furthermore, the movable part 22a may have a space portion for accommodating the fluid layer 22. That is, the fluid layer 22 may be installed in the space portion of the movable part 22a. The space portion may be formed by a vertically formed side wall.

[0103] Furthermore, the movable part 22a can be formed in a manner that the center portion protrudes from the lower portion of the housing 24. The movable part 22a can be a leaf spring having elastic force. In this case, the movable part 22a can be supported by a force greater than the destructive force of the fluid layer 22.

[0104] Furthermore, the center portion of the movable member 22a can be elastically deformed downward by an external force. That is, the movable member 22a can provide elastic force on the curved inclined surface connecting the lower surface and the protruding upper surface. The movable member 22a can have a predetermined height to be elastically deformed downward so as to provide a force sufficient to insert the microneedles of the microneedle array 25 into the skin.

[0105] Furthermore, the movable part 22a may be provided with one side protruding outward. Memos, for example, the patient's condition, etc. may be recorded in the protruding part.

[0106] The working part 23 is disposed at the upper end of the housing 24 and at the upper part of the microneedle array 25. The working part 23 works so that the user applies external force to insert the microneedle into the skin. In this case, the working part 23 can release the supporting force of the fluid layer 22 by means of external force, so that the working part 23 pressurizes the microneedle array 25. As described above, the working part 23 can be operated by the user. In addition, the working part 23 can be in the shape of a disc.

[0107] In this case, the center portion of the upper surface of the working member 23 may be concave in shape. That is, a groove portion may be provided at the center of the upper surface of the working member 23 so that the user's finger is located in the center of the working member 23 .

[0108] Thus, the external force applied by the user can be uniformly applied to the entire working part 23. Therefore, the uniform lowering of the microneedle array 25 can be further ensured.

[0109] Furthermore, the working part 23 can pressurize the microneedle array 25 by breaking the force of the fluid layer 22 by an external force. In other words, the working part 23 can pressurize the microneedle array 25 by releasing the supporting force through the fluid layer 22. In this case, the working part 23 can pressurize the microneedle array 25 through the movable part 22a.

[0110] The housing 24 accommodates the working part 23 and the microneedle array 25. In this case, the working part 23 may be exposed to the outside from the upper end of the housing 24 so that it can be operated by the user. Among them, the movable part 22a may be arranged to support the lower end of the housing 24. That is, the housing 24 may be arranged on the upper side of the movable part 22a. Thus, the housing 24 does not directly contact the skin.

[0111] Furthermore, the housing 24 is cylindrical in shape as a whole, and may have a hollow portion in the center for accommodating the working part 23 and the microneedle array 25. The housing 24 may have a first hollow portion in the upper portion for accommodating the fluid layer 22 and the working part 23, and may have a second hollow portion in the lower portion for accommodating the movable part 22a and the microneedle array 25. In this case, the width of the first hollow portion may be smaller than the width of the second hollow portion. Furthermore, both the upper and lower sides of the housing 24 may be open.

[0112] Furthermore, the housing 24 may have a specified height so that the working part 23 can be vertically lowered while preventing rotation or horizontal twisting to provide a force sufficient to insert the microneedles of the microneedle array 25 into the skin. The housing 24 may be configured to accommodate a surface perpendicular to the inner side of the working part 23 and the microneedle array 25.

[0113] The microneedle array 25 is provided with a plurality of microneedles containing drugs. The microneedles may be formed of a biodegradable substance. And, as described above, the drug may be a local anesthetic drug. In this case, the hardness of the microneedles may be 0.5N or less. And, the microneedles may be formed into a suitable shape suitable for insertion into the skin. As an example, the microneedles may be conical, but are not limited thereto.

[0114] The microneedle array 25 may be provided on the lower surface of the protruding portion at the center of the movable part 22a. That is, the microneedle array 25 may be provided on the lower surface at a position corresponding to the fluid layer 22 accommodated in the movable part 22a. In this case, the microneedle array 25 may be attached to the movable part 22a through an adhesive layer.

[0115] On the other hand, although not shown in the drawings, the microneedle applicator 20 according to the second embodiment may include the guide member 11 and the adhesive layer 16 of the first embodiment.

[0116] The first guide member may be protrudingly disposed at at least one position on the side of the working member 23. In addition, the second guide member is disposed at a position on the inner side surface of the housing 24 corresponding to the first guide member.

[0117] Furthermore, the second guide member may be in a shape corresponding to the first guide member and inserted into the first guide member. In this case, the first guide member slides in the second guide member so that the microneedle array 25 is uniformly lowered through the working member 23 and the movable member 22a by an external force applied by a user.

[0118] It is a matter of course that the first guide component and the second guide component are in opposite shapes, so that the first guide component is in a groove shape and the second guide component is in a protrusion shape.

[0119] Also, an adhesive layer may be provided at the lower portion of the movable member 22a. In the adhesive layer, an adhesive is applied to the lower surface so as to be able to adhere to the skin.

[0120] Below, refer to Figure 5 , describing the operation of the microneedle applicator 20.

[0121] Reference Figure 5 As shown in part (a), in a state where the fluid layer 22 supports the working part 23, the movable part 22a in the microneedle applicator 20 supports the fluid layer 22 and the working part 23 through the protruding part at the center.

[0122] In this case, the side wall of the housing 24 can expand the skin in contact therewith outward by the support force of the fluid layer 22. Thus, the microneedle is inserted into the expanded skin, thereby improving the insertion efficiency and ensuring the insertion stability.

[0123] As shown in part (b), when the working part 23 is pushed by the user, the working part 23 destroys the fluid layer 22 and vertically descends to the lower surface of the housing 14 while preventing rotation or horizontal twisting. In this case, the supporting force of the movable part 22a is greater than the pressure of the fluid layer 22, so the fluid layer 22 can be destroyed between the working part 23 and the movable part 22a.

[0124] Therefore, the center of the movable part 22a is vertically lowered by elastic deformation of the inclined surface through the working part 23, so that the microneedle array 25 protrudes to the outside of the housing 24. In this case, the microneedle array 25 contacts the skin, and the microneedles are inserted into the skin by the force of the working part 23 destroying the fluid layer 22.

[0125] As described above, the microneedle applicator 20 according to the second embodiment of the present invention can provide external force to the microneedle array 25 by releasing the supporting force of the fluid layer 22. Therefore, the microneedle applicator 20 according to the second embodiment of the present invention can provide external force with a simpler structure, thereby saving manufacturing costs and improving price competitiveness.

[0126] Figure 6 is an exploded perspective view of a microneedle applicator according to a third embodiment of the present invention, Figure 7 1 is a diagram for explaining the operation of the microneedle applicator according to the third embodiment of the present invention.

[0127] Reference Figure 6 The microneedle applicator 30 according to the third embodiment of the present invention includes a rubber band 32 , a working component 33 , a housing 34 and a microneedle array 35 .

[0128] The microneedle applicator 30 according to the third embodiment provides external force by an elastic member, and a rubber band 32 is provided as the elastic member.

[0129] The rubber band 32 is disposed between the working component 33 and the microneedle array 35. The rubber band 32 may be in the shape of a line with a specified width.

[0130] The center of the rubber band 32 may be fixed by the working part 33. In addition, the other side of the rubber band 32 may be fixed to the linkage part 32a. In this case, the rubber band 32 may be elastically deformed to the extent of the distance between the working part 33 and the linkage part 32a to generate elastic force. The rubber band 32 may be arranged in an oblique line between the working part 33 and the linkage part 32a on one side and between the working part 33 and the linkage part 32a on the other side.

[0131] The linkage component 32a may support the microneedle array 35 at the lower side of the microneedle array 35. Also, the linkage component 32a may be disposed at the upper side of the microneedle array 35. In this case, the microneedle array 35 may be attached to the linkage component 32a. The linkage component 32a may be provided with a through hole at the center so that the microneedle array 35 is exposed to the lower side.

[0132] Furthermore, the linkage component 32a has a function of transmitting the elastic force of the rubber band 32 to the microneedle array 35. In this case, as the fixing of the rubber band 32 is released, the linkage component 32a can make the microneedle array 35 fall vertically.

[0133] Furthermore, the linkage component 32a may be plate-shaped. The linkage component 32a may have a strength greater than the elastic force of the rubber band 32. Therefore, the shape will not be deformed by the elastic deformation force of the rubber band 32.

[0134] The working part 33 is provided at the upper end of the housing 34 and is provided on the upper side of the microneedle array 35. The working part 33 works so that the user applies external force to insert the microneedle into the skin. In this case, the working part 33 provides the elastic restoring force of the rubber band 32 so that the microneedle array 35 is pressurized by the elastic force of the external force.

[0135] Furthermore, the working part 33 fixes the center of the rubber band 32 so that the rubber band 32 has elasticity on the upper side of the microneedle array 35. The working part 33 can be arranged in a horizontally slidable manner. That is, the working part 33 can slide in a direction perpendicular to the rubber band 32. As described above, the working part 33 can be operated by the user.

[0136] In this case, when the working member 33 is horizontally moved to the outside of the housing 34 by the external force of the user, the rubber band 32 may be released. Therefore, the microneedle array 35 may be pressurized through the linkage member 32a by the elastic restoring force of the rubber band 32.

[0137] The case where the operating member 33 moves horizontally toward the outside of the housing 34 in a horizontal rod shape is described as an example, but the present invention is not particularly limited thereto and may also be a structure capable of providing elastic force to the rubber band 32 .

[0138] As an example, the working part 33 may be provided in a vertical rod shape and may be provided in a manner that allows vertical movement toward the upper side of the housing 34. In this case, the rubber band 32 is elastically deformed in a vertical direction as the working part 33 moves vertically when provided at the lower side of the housing 34. Then, as the external force is removed from the working part 33, the microneedle array 35 may be pressurized by the elastic restoring force of the rubber band 32. The rubber band 32 may be supported by the working part 33 and the linkage part 32a.

[0139] As another example, the working part 33 is provided in a form having a rotational force so as to rotate on the upper side of the housing 34. In this case, the rubber band 32 is elastically deformed as it rotates in the housing 34. Then, as the external force is removed from the working part 33, the microneedle array 35 can be pressurized by the elastic restoring force of the rubber band 32. Here, the rubber band 32 can be supported by the working part 33 and the linkage part 32a.

[0140] The housing 34 accommodates the working part 33 and the microneedle array 35. In this case, the working part 33 may be exposed to the outside from the upper end of the housing 34 so as to be operable by a user. The housing 34 is shown as an upper end, a side wall, and a lower end, but is substantially provided in an integrated manner. Therefore, the housing 34 is cylindrical as a whole.

[0141] Furthermore, the housing 34 is provided with a hollow portion at the center thereof for accommodating the rubber band 32, the linkage member 32a and the microneedle array 35. That is, both the upper side and the lower side of the housing 34 can be opened.

[0142] Furthermore, the housing 34 may have a predetermined height so that the linkage component 32a vertically descends to provide a force sufficient to insert the microneedles of the microneedle array 35 into the skin. The housing 34 may be configured to accommodate a surface perpendicular to the inner side of the linkage component 32a and the microneedle array 35.

[0143] The microneedle array 35 is provided with a plurality of microneedles containing drugs. The microneedles may be formed of a biodegradable substance. And, as described above, the drug may be a local anesthetic drug. In this case, the hardness of the microneedles may be 0.5N or less. And, the microneedles may be formed into a suitable shape suitable for insertion into the skin. As an example, the microneedles may be conical, but are not limited thereto.

[0144] Also, the microneedle array 35 may be disposed at the center portion of the interlocking member 32a. In this case, the microneedle array 35 may be attached to the upper and lower sides of the interlocking member 32a through an adhesive layer.

[0145] On the other hand, although not illustrated in the drawings, the microneedle applicator 30 according to the third embodiment may include the guide member 11 and the adhesive layer 16 of the first embodiment.

[0146] The first guide member may be protrudingly disposed at at least one position on the side of the linkage member 32a. In addition, the second guide member is disposed at a position on the inner side surface of the housing 34 corresponding to the first guide member.

[0147] Furthermore, the second guide member is in a shape corresponding to the first guide member and is inserted into the first guide member. In this case, the first guide member slides in the second guide member, so that the microneedle array 35 is uniformly lowered through the working member 33 and the linkage member 32a by means of an external force applied by a user.

[0148] Of course, the first guide member and the second guide member are in opposite shapes, so that the first guide member is in a groove shape and the second guide member is in a protrusion shape. And, an adhesive layer may be provided at the lower portion of the housing 34. In the adhesive layer, an adhesive is applied to the lower surface so as to be able to adhere to the skin.

[0149] Below, refer to Figure 7 , illustrating the operation of the microneedle applicator 30.

[0150] Reference Figure 7 As shown in part (a), in the microneedle applicator 30, both ends of the rubber band 32 are fixed to the linkage part 32a, and the center part is buckled into the working part 33. In this case, the rubber band 32 is in a state of elastic deformation through the working part 33 and the linkage part 32a. Among them, the microneedle array 35 is provided near the lower surface of the housing 34 in an integrated manner with the linkage part 32a. Optionally, the microneedle array 35 can also be provided near the upper surface of the housing 34 in an integrated manner with the linkage part 32a.

[0151] As shown in part (b), when the actuating member 33 is slid outward by the user, the center portion of the rubber band 32 fixed by the actuating member 33 is released, and the rubber band 32 is urged downward by elastic restoring force.

[0152] As shown in part (c), the elastic restoring force of the rubber band 32 is transmitted to the linkage part 32a, so that the microneedle array 35 protrudes outward from the lower surface of the housing 34. Therefore, the microneedle array 35 contacts the skin, and the microneedles are inserted into the skin by the elastic restoring force of the rubber band 32.

[0153] As described above, the microneedle applicator 30 according to the third embodiment of the present invention can provide external force to the microneedle array 35 through the elastic restoring force of the rubber band 32. Therefore, the microneedle applicator 30 according to the third embodiment of the present invention can improve the convenience of use, because the user only needs a small force to provide an external force sufficient to insert the microneedles into the skin.

[0154] Figure 8 is an exploded perspective view of a microneedle applicator according to a fourth embodiment of the present invention, Fig. 9 1 and 2 are diagrams for explaining the operation of the microneedle applicator according to the fourth embodiment of the present invention.

[0155] Reference Figure 8 The microneedle applicator 40 according to the fourth embodiment of the present invention includes a leaf spring 42 , a working component 43 , a housing 44 and a microneedle array 45 .

[0156] The microneedle applicator 40 according to the fourth embodiment provides external force by an elastic member, and a leaf spring 42 is provided as the elastic member.

[0157] The leaf spring 42 is disposed between the working part 43 and the microneedle array 45. The leaf spring 42 may be formed to protrude at the center. In this case, the center of the leaf spring 42 may be elastically deformed toward the lower side by an external force. That is, the leaf spring 42 may provide an elastic force on the curved inclined surface connecting the lower surface and the protruding upper surface. The leaf spring 42 may have a predetermined height to elastically deform toward the lower side so as to provide a force sufficient to insert the microneedles of the microneedle array 45 into the skin. In this case, the leaf spring 42 may be elastically deformed to the extent of the height of the protruding portion to generate an elastic force.

[0158] The leaf spring 42 supports the lower end of the working member 43. The leaf spring 42 can support the working member 43 with a supporting force corresponding to the elastic force of the curved inclined surface.

[0159] The working part 43 is disposed at the upper end of the housing 44 and at the upper part of the microneedle array 45. The working part 43 works so that the user applies external force to insert the microneedles into the skin. In this case, the microneedle array 45 is pressurized by the elastic force of the external force, and the working part 43 presses the leaf spring 42 to provide elastic deformation force. As described above, the working part 43 can be operated by the user. In addition, the working part 43 can be in the shape of a disk.

[0160] In this case, the center of the upper surface of the working member 43 may be concave, that is, a groove may be provided at the center of the upper surface of the working member 43 to guide the user's finger to be located at the center of the working member 43 .

[0161] Thus, the external force applied by the user can be uniformly applied to the entire working part 43. Therefore, the uniform lowering of the microneedle array 45 can be further ensured.

[0162] Furthermore, the operating member 43 can pressurize the microneedle array 45 by elastically deforming the leaf spring 42 with the help of an external force. In other words, when the operating member 43 pressurizes the leaf spring 42 with the help of an external force, the microneedle array 45 can be pressurized by the elastic deformation force of the leaf spring 42 .

[0163] The housing 44 accommodates the leaf spring 42, the working part 43 and the microneedle array 45. In this case, the working part 43 can be exposed to the outside from the upper end of the housing 44 so that it can be operated by the user. The leaf spring 42 can be arranged in a manner to support the lower end of the housing 44. That is, the housing 44 can be arranged on the upper side of the leaf spring 42. As a result, the housing 44 does not directly contact the skin.

[0164] The housing 44 is cylindrical in shape as a whole, and may have a hollow portion at the center for accommodating the leaf spring 42, the working component 43, and the microneedle array 45. The housing 44 may have a first hollow portion at the upper portion for accommodating the working component 43, and may have a second hollow portion at the lower portion for accommodating the leaf spring 42 and the microneedle array 45. In this case, the width of the first hollow portion may be smaller than the width of the second hollow portion. In addition, both the upper and lower sides of the housing 44 may be open.

[0165] The housing 44 may have a specified height so that the working part 43 drops vertically to provide a force sufficient to insert the microneedles of the microneedle array 45 into the skin. The housing 44 may be configured to accommodate a vertical surface of the inner side of the working part 43 .

[0166] The microneedle array 45 is provided with a plurality of microneedles containing drugs. The microneedles may be formed of a biodegradable substance. And, as described above, the drug may be a local anesthetic drug. In this case, the hardness of the microneedles may be 0.5N or less. And, the microneedles may be formed into a suitable shape suitable for insertion into the skin. As an example, the microneedles may be conical, but are not limited thereto.

[0167] Also, the microneedle array 45 may be provided on the lower surface of the protruding portion at the center of the leaf spring 42. In this case, the microneedle array 45 may be attached to the leaf spring 42 through an adhesive layer.

[0168] Alternatively, the microneedle array 45 may be disposed on an additional support body. In this case, the support body may be disposed between the leaf spring 42 and the microneedle array 45. That is, the microneedle array 45 may be disposed separately from the leaf spring 42.

[0169] On the other hand, although not shown in the drawings, the microneedle applicator 40 according to the fourth embodiment may include the guide member 11 and the adhesive layer 16 of the first embodiment.

[0170] The first guide member may be protrudingly disposed at at least one position on the side of the working member 43. In addition, the second guide member is disposed on the inner side surface of the housing 44 at a position corresponding to the first guide member.

[0171] Furthermore, the second guide member is in a shape corresponding to the first guide member and is inserted into the first guide member. In this case, the first guide member slides in the second guide member, so that the microneedle array 45 is uniformly lowered by the working member 43 and the leaf spring 42 with the help of an external force applied by the user.

[0172] It is a matter of course that the first guide component and the second guide component are in opposite shapes, so that the first guide component is in a groove shape and the second guide component is in a protrusion shape.

[0173] Also, an adhesive layer may be provided at the lower portion of the leaf spring 42. In the adhesive layer, an adhesive is applied to the lower surface to enable attachment to the skin.

[0174] Below, refer to Fig. 9 , illustrating the operation of the microneedle applicator 40.

[0175] Reference Fig. 9 As shown in part (a), in the microneedle applicator 40, the working member 43 protrudes toward the upper part of the housing 44, and the leaf spring 42 supports the working member 43 through the protruding portion at the center.

[0176] As shown in part (b), when the working part 43 is pushed by the user, the working part 43 presses the center of the leaf spring 42. In this case, the inclined surface of the leaf spring 42 is elastically deformed, and the center thereof vertically drops downward, so that the microneedle array 45 protrudes to the outside of the housing 44. Therefore, the microneedle array 45 contacts the skin, and the microneedles are inserted into the skin by the elastic deformation force of the leaf spring 42.

[0177] As described above, the microneedle applicator 40 according to the fourth embodiment of the present invention can provide an external force to the microneedle array 45 through the elastic deformation force of the leaf spring 42. Therefore, the microneedle applicator 40 according to the fourth embodiment of the present invention can improve the convenience of use, because the user only needs a small force to provide an external force sufficient to insert the microneedle into the skin.

[0178] Fig.10 1 is a diagram showing a microneedle applicator according to a fifth embodiment of the present invention.

[0179] Reference Fig.10 As shown in part (a), the microneedle applicator 50 according to the fifth embodiment of the present invention includes a working part 53 , a housing 54 and a microneedle array 55 .

[0180] In the microneedle applicator 50 according to the fifth embodiment, the guide member and the locking member are formed integrally.

[0181] The working part 53 is arranged at the upper end of the shell 54 and at the upper part of the microneedle array 55. Among them, the working part 53 may have the same shape as the opening 54a of the shell 54. That is, the outer periphery of the working part 53 may have the same shape as the inner periphery of the opening 54a of the shell 54. In addition, the working parts 53 can be staggered at a specified angle so that they can be supported by the edge of the opening 54a of the shell 54. In this case, the portion 53a located outside the opening 54a of the shell 54 and the edge of the shell 54 can be used as a locking part. As an example, the working part 53 can be polygonal, preferably rectangular. As another example, the working part 53 may include its curved outer periphery. Preferably, the working part can be circular.

[0182] In this case, the center of the upper surface of the working member 53 may be concave, that is, the center of the upper surface of the working member 53 may have a groove portion so as to guide the user's finger to be located in the center of the working member 53 .

[0183] Thus, the external force applied by the user can be uniformly applied to the entire working part 53. Therefore, the uniform lowering of the microneedle array 55 can be further ensured.

[0184] Furthermore, the working part 53 can be rotatably combined with the housing 54. That is, the working part 53 can be rotated by an external force. When the working part 53 is aligned with the opening 54a of the housing 54, the supporting force between a portion 53a of the working part 53 and the edge of the housing 54 can be released. Therefore, the working part 53 can pressurize the microneedle array 55 by an external force.

[0185] The housing 54 is used to accommodate the working part 53 and the microneedle array 55. As an example, the housing may have an opening 54a having the same shape as the working part 53. The opening 54a may be arranged according to the center of the housing 54.

[0186] The microneedle array 55 is provided with a plurality of microneedles containing drugs. The microneedles may be formed of a biodegradable substance. And, as described above, the drug may be a local anesthetic drug. In this case, the hardness of the microneedles may be 0.5N or less. And, the microneedles may be formed into a suitable shape suitable for insertion into the skin. As an example, the microneedles may be conical, but are not limited thereto.

[0187] Also, the microneedle array 55 may be disposed at a lower portion of the working member 53. In this case, the microneedle array 55 may be attached to the working member 53 through an adhesive layer.

[0188] On the other hand, although not shown in the drawings, the microneedle applicator 50 according to the fifth embodiment may include the guide member 11 and the adhesive layer 16 of the first embodiment.

[0189] As shown in part (b), the working part 53 can be rotated by external force until it is aligned with the opening 54a of the housing 54. When the working part 53 is aligned with the opening 54a of the housing 54, the working part 53 slides along the opening 54a of the housing 54, so that the microneedle array 55 is uniformly vertically lowered while preventing rotation or horizontal twisting.

[0190] In this case, the side wall of the housing 54 can expand the skin in contact therewith outward by the supporting force of the working member 53. Thus, the microneedle is inserted into the expanded skin, thereby improving the insertion efficiency and ensuring the insertion stability.

[0191] Next, in the operating member 53, the microneedle array 55 protrudes to the outside of the housing 54. Therefore, the microneedle array 55 comes into contact with the skin, and the microneedles are inserted into the skin by the force of releasing the supporting force of the operating member 53.

[0192] As described above, the microneedle applicator 50 according to the fifth embodiment of the present invention can provide an external force to the microneedle array 55 by releasing the supporting force of the edge 53a of the working member 53. Therefore, the microneedle applicator 50 according to the fifth embodiment of the present invention can provide an external force with a simpler structure, and thus can save manufacturing costs, thereby improving price competitiveness.

[0193] The embodiments of the present invention are described above, but the spirit of the present invention is not limited to the embodiments described in this specification. Those skilled in the art who understand the spirit of the present invention can easily propose other embodiments within the scope of the same spirit by appending, changing, deleting, adding, etc. to structural elements, but this will also fall within the scope of the spirit of the present invention.

Claims

1. A microneedle applicator, wherein: include: Microneedle arrays; A working component is arranged on the upper part of the microneedle array to work so that a user applies external force to insert the microneedles into the skin; A housing for accommodating the microneedle array and the working component; A first guide member, disposed at at least one position on the side of the working member or at least one position on the side of the linkage member of the working member; and A second guide component is disposed at a position corresponding to the first guide component on the inner side of the housing and is engaged with the first guide component, and the first guide component slides so that the microneedle array is uniformly vertically lowered by the external force while preventing rotation or horizontal twisting. The housing includes a locking member configured to support a lower end portion of the working member. The locking member is arranged to protrude from the inner side surface of the housing toward the center side. The locking member is arranged to form a gap in the upward direction from the bottom surface of the housing. The working component is lowered to the bottom surface of the housing through the locking component by the external force, thereby pressurizing the microneedle array. The center of the upper surface of the working component has a groove portion.

2. The microneedle applicator according to claim 1, wherein: The hardness of the microneedle is less than 0.5N.

3. The microneedle applicator according to claim 2, wherein: The microneedle array contains a drug, The drug comprises a local anesthetic drug selected from the group consisting of procaine, chloroprocaine, tetracaine, dibucaine, lidocaine, mepivacaine, benzocaine, bupivacaine, and a combination thereof.

4. The microneedle applicator according to claim 1, wherein: The first guide member is arranged in a straight line along a vertical direction on the side of the working member.

5. The microneedle applicator according to claim 4, wherein: The second guide member has different widths depending on a position on a horizontal cross section of the housing.

6. The microneedle applicator according to claim 1, wherein: The microneedle applicator further comprises an adhesive layer disposed at the lower portion of the housing and attached to the skin, The adhesive layer has an opening at a center portion and a release portion having one side protruding outward.

7. A microneedle applicator, wherein: include: Microneedle arrays; A working component is arranged on the upper part of the microneedle array to work so that a user applies external force to insert the microneedles into the skin; A housing for accommodating the microneedle array and the working component; A first guide member, disposed at at least one position on the side of the working member or at least one position on the side of the linkage member of the working member; and A second guide component is disposed at a position corresponding to the first guide component on the inner side of the housing and is engaged with the first guide component, and the first guide component slides so that the microneedle array is uniformly vertically lowered by the external force while preventing rotation or horizontal twisting. The housing includes a locking member configured to support a lower end portion of the working member. The locking member is a groove portion provided on the inner side surface of the housing. The working member is provided with a protrusion portion inserted into the groove portion along the outer circumference, The locking member is arranged to form a gap in the upward direction from the bottom surface of the housing. The working component is lowered to the bottom surface of the housing through the locking component by the external force, thereby pressurizing the microneedle array. The center of the upper surface of the working component has a groove portion.

8. The microneedle applicator according to claim 1 or 7, wherein: The microneedle array is a microneedle patch.

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