Detachable magnetic stimulation device for animal brain

Abstract

The detachable magnetic stimulation device for the animal brain comprises a fixed connecting device and a magnetic field excitation device, the fixed connecting device comprises a connecting cover, a zipper is arranged on one side of the connecting cover, and the connecting cover is arranged in a fan shape; the magnetic field excitation device comprises a permanent magnet, an electromagnetic coil and a signal controller, the permanent magnet generates a static magnetic field, the magnetic field excitation device and the signal controller are bonded on the fixed connecting device, the electromagnetic coil is connected with the signal controller, and the signal controller can supply power to the electromagnetic coil. The magnetic stimulation device is fixed on the head of an animal, long-term noninvasive static magnetic field or pulse magnetic field stimulation on the brain of the animal can be realized under the condition that the daily life of the animal is not influenced, and meanwhile, by replacing permanent magnets or electromagnetic coils with different polarities, shapes, arrangement modes and placement positions, the magnetic stimulation device can be used for stimulating the brain of the animal. Different modes of magnetic stimulation on a single or multiple brain areas of the animal brain can be achieved, and the requirement for magnetic stimulation in animal treatment is met.

Description

Technical Field

[0001] The present invention relates to the field of magnetic field therapy technology, and in particular to a detachable magnetic stimulation device for animal brains. Background Art

[0002] At present, brain magnetic stimulation is widely recognized in the fields of clinical psychiatry, neurology and neurorehabilitation, but its application in animals is limited to animal experiments, and brain magnetic stimulation equipment also faces many limitations when conducting animal experiments.

[0003] On the one hand, most of the brain magnetic stimulation devices disclosed on the market use commercial human coils, which are much larger than the animal's brain and will stimulate a large amount of non-target organ tissue, making it impossible to provide targeted treatment. Moreover, these brain magnetic stimulation devices are handheld when used, and the coils cannot be fixed on the head. If the animal's head shakes slightly, the accuracy of the stimulation will be reduced.

[0004] On the other hand, animals need to be fixed when receiving brain magnetic stimulation treatment. The current fixation methods used in experiments are mainly hand-held fixation and fixture-type fixation. Hand-held fixation mainly requires professional experimenters to restrain the animals with their bare hands. The main disadvantage of this fixation method is that it requires high stability for the experimenters. It is necessary to keep the distance between the magnetic stimulation coil and the animal's head as stable as possible, and the experimenters are easily fatigued over time. Fixation-type fixation is to fix the animals with some fixing devices. The main disadvantage of this fixation method is that it is strongly restrained on the animals, and the animals will feel uncomfortable. In addition, the animals may need to be anesthetized during fixation, which makes the operation more difficult. Therefore, it has become an urgent problem to allow animals to conduct magnetic stimulation experiments in a free state.

[0005] For example, a Chinese invention patent with announcement number CN108606856A discloses a transcranial magnetic stimulation coil fixing device and method for mice with small-range activities. The device has a fixed front plate arranged at the upper end of a base for setting a coil, a fixed rear plate connected to one side of the fixed front plate for limiting the range of mouse activities by binding the mouse, and a coil fixing structure is integrally formed on the upper end surface of the fixed front plate. Although this method can be used for transcranial magnetic stimulation experiments in mice with small-range activities, the coil size is much larger than the mouse's brain, which will stimulate a large number of non-target organ tissues and cannot perform targeted treatment. For this reason, we propose a detachable magnetic stimulation device for animal brains to solve the above problems. Summary of the invention

[0006] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a detachable magnetic stimulation device for animal brain.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] A detachable magnetic stimulation device for animal brain, comprising a fixed connection device and a magnetic field excitation device,

[0009] The fixed connection device comprises a connection cover, a zipper is provided on one side of the connection cover, the connection cover is arranged in a fan shape, the connection cover is made of soft plastic material, one end of the connection cover is connected to a flexible sleeve layer, both sides of the flexible sleeve layer are connected to connecting belts, a second Velcro is pasted on one side of the connection cover, and the first Velcro is pasted on the second Velcro;

[0010] The magnetic field excitation device includes a permanent magnet, an electromagnetic coil and a signal controller. The permanent magnet generates a static magnetic field. The magnetic field excitation device and the signal controller are bonded to a fixed connection device. The electromagnetic coil is connected to the signal controller. The signal controller can supply power to the electromagnetic coil and is used to adjust the parameters or working state of the electromagnetic coil to generate a pulsed magnetic field.

[0011] Preferably, the permanent magnet includes N-pole magnetic particles and S-pole magnetic particles adhered to one side of the first Velcro.

[0012] Preferably, the permanent magnet includes an S-pole magnetic strip and an N-pole magnetic strip bonded to one side of the first Velcro.

[0013] Preferably, the permanent magnet includes a plurality of first magnetic particles of different sizes which are arranged at equal intervals on one side of the first Velcro, and the first magnetic particles are arranged in order from large to small.

[0014] Preferably, the permanent magnet includes a plurality of second magnetic particles which are arranged at equal intervals on one side of the first Velcro, and the second magnetic particles are evenly arranged relative to each other.

[0015] Preferably, the permanent magnet includes a first magnet bonded to one side of one of the first Velcro strips, and a counterweight corresponding to the first magnet is provided on one side of the other first Velcro strip.

[0016] Preferably, the permanent magnet comprises a plurality of second Velcros which are evenly spaced and arranged on one side of the connecting cover, the first Velcros are adhered to the second Velcros, and a second magnet is provided on one side of the first Velcro.

[0017] Preferably, the electromagnetic coil includes a circular coil and an 8-shaped coil.

[0018] Preferably, the signal controller includes a power module, a driver and a microcontroller, the power module is used to supply power to the electromagnetic coil, the driver is used to perform timing control of the driving current of the stimulation coil according to a preset coil stimulation intensity and stimulation timing, and the microcontroller controls the timing and magnitude of the electromagnetic coil current.

[0019] The fixed position of the permanent magnet or electromagnetic coil is determined according to the animal's brain, and a non-magnetic weight can be added at the opposite side of the permanent magnet or electromagnetic coil to achieve more accurate and stable treatment of the animal's brain by the permanent magnet or electromagnetic coil.

[0020] Select a suitable permanent magnet or electromagnetic coil according to the desired magnetic field effect mode. Permanent magnets or electromagnetic coils with different polarities, shapes, arrangements, and placements have different effects on the animal brain.

[0021] When in use, the present invention is folded into a ring structure, which can be wrapped around and fixed on the head of an animal. Velcro is attached to the inner side of the connecting cover, and permanent magnets or electromagnetic coils of different specifications are adhered to one side of the Velcro to generate a static magnetic field or a pulsed magnetic field to achieve electromagnetic stimulation of the animal's brain. The electromagnetic coil is connected to a signal controller, and the signal controller can be used to adjust the parameters or working state of the magnetic field generated by the electromagnetic coil.

[0022] Compared with the prior art, the present invention has the following advantages:

[0023] 1. The present invention fixes the magnetic stimulation device on the animal's head, which can achieve long-term non-invasive static magnetic field or pulse magnetic field stimulation on the animal's brain without affecting the animal's daily life;

[0024] 2. The present invention can select permanent magnets and electromagnetic coils of appropriate sizes according to the body size of the animal. At the same time, by replacing permanent magnets or electromagnetic coils of different polarities, shapes, arrangements, and placements, different modes of magnetic stimulation of a single or multiple brain regions of the animal can be achieved, thus meeting the requirements for magnetic stimulation in animal treatment or animal experiments.

[0025] 3. The present invention is easy to install and operate, has strong flexibility, and greatly improves the convenience and speed of use;

[0026] In summary, the present invention fixes the magnetic stimulation device on the head of the animal, and can achieve long-term non-invasive static magnetic field or pulse magnetic field stimulation of the animal's brain without affecting the animal's daily life. At the same time, by replacing permanent magnets or electromagnetic coils with different polarities, shapes, arrangements, and placement positions, different modes of magnetic stimulation of a single or multiple brain regions of the animal's brain can be achieved, which meets the requirements for magnetic stimulation in animal treatment. At the same time, it is convenient to install and operate, has strong flexibility, greatly improves the convenience and speed of use, and can also achieve the effects of different magnetic field effects such as static magnetic field and pulse stimulation on the brain. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is the internal structure diagram of the present invention;

[0028] Figure 2It is the external structure diagram of the present invention;

[0029] Figure 3 The structure diagram of the S-pole magnetic particles of the present invention;

[0030] Figure 4 The N-pole magnetic particle arrangement structure diagram of the present invention;

[0031] Figure 5 The S-pole magnetic stripe of the present invention is provided with a structural diagram;

[0032] Figure 6 The N-pole magnetic stripe of the present invention is provided with a structural diagram;

[0033] Figure 7 A structural diagram of a plurality of first magnetic particles of different sizes in the present invention;

[0034] Figure 8 A structural diagram of a plurality of second magnetic particles of the present invention arranged at equal intervals;

[0035] Fig. 9 A structural diagram of a second magnet arrangement of the present invention;

[0036] Fig.10 A structural diagram of the first magnet and the counterweight block of the present invention;

[0037] Fig.11 This is a diagram showing the bonding structure of the first Velcro and the second Velcro of the present invention;

[0038] Fig.12 A structural diagram of a circular coil arrangement of the present invention;

[0039] Fig.13 The structure diagram of the 8-shaped coil of the present invention is provided;

[0040] Fig.14 A schematic diagram of magnetic stimulation timing control of the magnetic stimulation device of the present invention;

[0041] Fig.15 The first experimental subject of the present invention wears the structural diagram;

[0042] Fig.16 This is a diagram of the wearing structure of the second experimental subject of the present invention.

[0043] In the figure: 1 first Velcro, 2 connecting cover, 3 S pole magnetic particle, 4 N pole magnetic particle, 5 N pole magnetic strip, 6 S pole magnetic strip, 7 first magnetic particle, 8 second magnetic particle, 9 first magnet, 10 counterweight, 11 second magnet, 12 second Velcro, 13 connecting belt, 14 flexible sleeve, 15 circular coil, 16 8-shaped coil, 17 signal controller. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0045] A detachable magnetic stimulation device for animal brain comprises a connection cover 2, one end of which is connected to a flexible sleeve layer 14, which is wrapped with flannel. When the fan-shaped device is fixed to the neck of the animal, if it is tight, it will not hurt the animal body.

[0046] Both sides of the flexible sleeve layer 14 are connected with connecting belts 13, a second Velcro 12 is pasted on one side of the connection cover 2, a first Velcro 1 is pasted on the second Velcro 12, an S-pole magnetic particle 3 is adhered to one side of the first Velcro 1, a zipper is provided on one side of the connection cover 2, and the connection cover 2 is arranged in a fan shape, which is convenient for designing the size of the fan-shaped device according to the body shape of the animal and the appropriate permanent magnet or electromagnetic coil, and has strong adaptability;

[0047] The connecting cover 2 is made of soft plastic material. The size of the fan-shaped device is designed according to the body shape of the animal and the appropriate permanent magnet or electromagnetic coil. The soft plastic has good plasticity and low price, and has the advantages of easy molding and cost reduction.

[0048] The detachable magnetic stimulation device is applicable to experimental animals including mice, rabbits, monkeys, pigs, etc., and is also applicable to domestic animals such as cats, dogs, etc., and is also applicable to animals raised in zoos such as lions, tigers, etc.

[0049] Example 1

[0050] Reference Figure 1-4 In this embodiment, one side of the first Velcro 1 is bonded with N-pole magnetic particles 4. By setting the N-pole magnetic particles 4 and the S-pole magnetic particles 3, the stimulation effect of permanent magnets with different polarities on the animal's brain can be achieved, and the magnetic particles (circular magnetic field focusing).

[0051] Example 2

[0052] Reference Figure 5 and Figure 6 As shown, the difference between this embodiment 2 and embodiment 1 is that this embodiment 2 also includes an S-pole magnetic strip 6 bonded to one side of the first Velcro 1, and an N-pole magnetic strip 5 bonded to one side of the first Velcro 1, which can realize the stimulating effect of permanent magnets of different shapes on the animal's brain (rectangular magnetic field has a wide range).

[0053] Example 3

[0054] Reference Figure 7 and Figure 8As shown, the difference between the present embodiment 3 and the embodiment 1 is that the present embodiment 3 further includes that a plurality of first magnetic particles 7 of different sizes are evenly spaced on one side of the first Velcro 1, and the first magnetic particles 7 are arranged in order from large to small in a gradient arrangement;

[0055] A plurality of second magnetic particles 8 are arranged at equal intervals on one side of the first Velcro 1, and the second magnetic particles 8 are evenly arranged relative to each other in a matrix arrangement, so that different arrangements of permanent magnets can achieve the stimulating effect on the animal brain.

[0056] Example 4

[0057] Reference Fig. 9 and Fig.10 As shown, the difference between the present embodiment 4 and the embodiment 1 is that the present embodiment 4 also includes that the second Velcro 12 is provided on both sides of the connection cover 2, the first Velcro 1 is bonded to the second Velcro 12, one side of one of the first Velcro 1 is provided with a first magnet 9, and the other side of the first Velcro 1 is provided with a counterweight 10 corresponding to the first magnet 9, and the magnet is placed only in the area of ​​the back of the head, and the magnetic field acts on the brain accurately, and the counterweight 10 is added on the opposite side to prevent the fan-shaped device from rotating, causing the position of the magnet to shift, and affecting the effect of the magnetic field;

[0058] A plurality of second Velcro strips 12 are provided at equal intervals on one side of the connecting cover 2, the first Velcro strip 1 is adhered to the second Velcro strip 12, a second magnet 11 is provided on one side of the first Velcro strip 1, and magnets are placed in a circle at corresponding positions to ensure that the magnetic field can act on the brain, and counterweights of the same weight as the magnets can also be placed at other positions to avoid the problem of inaccurate action of the magnetic field on the back of the head.

[0059] Example 5

[0060] Reference Figure 12-14 As shown, the difference between this embodiment 5 and embodiment 1 is that:

[0061] This embodiment 5 provides a magnetic stimulation device, including a stimulation coil, a driver and a microcontroller, the driver and the microcontroller are electrically connected to the stimulation coil, the driver is used to control the timing of the driving current of the stimulation coil according to the preset coil stimulation intensity and stimulation timing, the timing and magnitude of the circular coil current are obtained by the microcontroller and the driver, which are timing 1 and driving current I1 respectively, and the timing and magnitude of the 8-shaped coil current are obtained by the microcontroller and the driver, which are timing 2 and driving current I2 respectively. In the embodiment, timing 1 and timing 2 may be the same or different. In the embodiment, driving current I1 and driving current I2 may be the same or different.

[0062] In this embodiment 5, the shapes of the stimulation coils include a circular coil and an 8-shaped coil; the 8-shaped coil can have a larger focal length than the circular coil while maintaining the field strength required for deep stimulation of the brain surface;

[0063] Stimulation coil materials include copper, iron, silver, and gold;

[0064] The number of turns of the stimulation coil is 25 to 50;

[0065] The driver is used to control the timing of the driving current of the stimulation coil according to the preset coil stimulation intensity and stimulation timing;

[0066] The current driving the stimulation coil is 1A to 10kA;

[0067] The stimulation frequency of driving the stimulation coil is 1KHz to 10KHz.

[0068] The microcontroller includes a half-bridge converter controlled by the microcontroller to activate the stimulation coil. The controller can also be responsible for managing the pulse sequence and the waiting time between each pulse sequence. The variability of these parameters will allow pulsed magnetic stimulation with different parameters to be provided according to specific needs.

[0069] In the present invention, when in use, according to the body shape of the animal and the magnetic field action mode to be applied, a suitable permanent magnet or electromagnetic coil and a suitable fan-shaped device are selected, and the second Velcro 12 is fixed to the connecting cover 2, wherein the smooth side of the second Velcro 12 is connected to the fan-shaped device, and then the permanent magnet or electromagnetic coil is fixed to the first Velcro 1, and the permanent magnet or electromagnetic coil is connected to the smooth side of the first Velcro, and then the first Velcro 1 with the permanent magnet or electromagnetic coil fixed is connected and bonded to the second Velcro 12 fixed on the fan-shaped device, wherein the fixed position of the second Velcro 12 on the fan-shaped device depends on the corresponding position of the brain of the animal after the animal puts on the fan-shaped device, so as to achieve stable brain treatment of the animal by the permanent magnet or electromagnetic coil.

[0070] The fixed position of the permanent magnet or electromagnetic coil is determined according to the animal's brain, and a non-magnetic weight can be added at the opposite side of the permanent magnet or electromagnetic coil to achieve more accurate and stable treatment of the animal's brain by the permanent magnet or electromagnetic coil.

[0071] Select a suitable permanent magnet or electromagnetic coil according to the desired magnetic field effect mode. Permanent magnets or electromagnetic coils with different polarities, shapes, arrangements, and placements have different effects on the animal brain.

[0072] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A detachable magnetic stimulation device for an animal's brain, characterized in that: It includes a fixed connection device and a magnetic field excitation device, The fixed connection device comprises a connection cover (2), a zipper is provided on one side of the connection cover (2), the connection cover (2) is arranged in a fan shape, the connection cover (2) is made of a soft plastic material, one end of the connection cover (2) is connected to a flexible sleeve layer (14), both sides of the flexible sleeve layer (14) are connected to connecting belts (13), a second magic tape (12) is adhered to one side of the connection cover (2), and the first magic tape (1) is adhered to the second magic tape (12); The magnetic field excitation device comprises a permanent magnet, an electromagnetic coil and a signal controller (17). The permanent magnet generates a static magnetic field. The magnetic field excitation device and the signal controller (17) are bonded to a fixed connection device. The electromagnetic coil is connected to the signal controller (17). The signal controller (17) can supply power to the electromagnetic coil and is used to adjust the parameters or working state of the electromagnetic coil to generate a pulsed magnetic field.

2. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises N-pole magnetic particles (4) and S-pole magnetic particles (3) adhered to one side of the first Velcro (1).

3. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises an S-pole magnetic strip (6) and an N-pole magnetic strip (5) bonded to one side of the first Velcro (1).

4. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises a plurality of first magnetic particles (7) of different sizes which are arranged at equal intervals on one side of the first Velcro (1), and the first magnetic particles (7) are arranged in order from large to small.

5. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises a plurality of second magnetic particles (8) which are arranged at equal intervals on one side of the first Velcro (1), and the second magnetic particles (8) are evenly arranged relative to each other.

6. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises a first magnet (9) bonded to one side of one of the first Velcro strips (1), and a counterweight (10) corresponding to the first magnet (9) is provided on one side of the other first Velcro strip (1).

7. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The permanent magnet comprises a plurality of second Velcro strips (12) which are arranged at equal intervals on one side of the connection cover (2); a first Velcro strip (1) is adhered to the second Velcro strips (12); and a second magnet (11) is provided on one side of the first Velcro strips (1).

8. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The electromagnetic coil comprises a circular coil (15) and an 8-shaped coil (16).

9. A detachable magnetic stimulation device for animal brain according to claim 1, characterized in that: The signal controller (17) comprises a power module, a driver and a microcontroller. The power module is used to supply power to the electromagnetic coil. The driver is used to control the timing of the driving current of the stimulation coil according to the preset coil stimulation intensity and stimulation timing. The microcontroller controls the timing and magnitude of the electromagnetic coil current.

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