Radiotherapy plan generation method and electronic equipment

Abstract

The invention provides a radiotherapy plan generation method and electronic equipment, and relates to the technical field of medical treatment. The specific implementation scheme is as follows: acquiring a first radiotherapy plan of an object to be subjected to radiotherapy in a first radiotherapy mode; in response to a dose conversion operation on the first radiotherapy plan, obtaining a first equivalent dose field obtained by performing dose conversion on the first radiotherapy plan; and by taking the first equivalent dose field as a basic dose field, generating a second radiotherapy plan of the to-be-radiotherapy object in a second radiotherapy mode. Therefore, under the condition that the same object to be subjected to radiotherapy corresponds to different radiotherapy modes, the radiotherapy plan of the object to be subjected to radiotherapy in another radiotherapy mode can be formulated according to the existing radiotherapy plan of the object to be subjected to radiotherapy in one radiotherapy mode. Moreover, the equivalent dose field obtained by performing dose conversion on the existing radiotherapy plan is taken as the basic dose field to formulate the new radiotherapy plan, so that the accuracy of the generated radiotherapy plan can be effectively improved.

Description

Technical Field

[0001] The present disclosure relates to the field of medical technology, and in particular to a method for generating a radiotherapy plan and an electronic device. Background Art

[0002] With the rapid development of computer technology and imaging technology, radiotherapy (abbreviated as radiotherapy) technology has also been maturing. Among them, radiotherapy is one of the important means of treating tumors, which achieves the purpose of eliminating tumors by giving tumors a sufficiently high radiation dose.

[0003] In order to ensure that a high dose is given to the tumor without causing excessive irradiation to normal tissues, a corresponding radiotherapy plan is usually formulated for the subject to be radiotherapy (i.e., the patient) based on the prescribed dose. In addition, during the process of formulating the radiotherapy plan, the formulated radiotherapy plan will also be evaluated to generate a radiotherapy plan with better treatment effect.

[0004] In particular, when the subject to be radiotherapy corresponds to different radiotherapy modes, how to formulate a radiotherapy plan for the subject to be radiotherapy is an issue worthy of attention. Summary of the invention

[0005] The present disclosure provides a method and electronic device for generating a radiotherapy plan, which are used to formulate a radiotherapy plan for the object to be radiotherapy in another radiotherapy mode according to an existing radiotherapy plan for the object to be radiotherapy in one radiotherapy mode when the same object to be radiotherapy corresponds to different radiotherapy modes.

[0006] According to one aspect of the present disclosure, a method for generating a radiotherapy plan is provided, the method comprising:

[0007] Obtaining a first radiotherapy plan for the subject to be radiotreated under a first radiotherapy mode;

[0008] In response to the dose conversion operation on the first radiotherapy plan, a first equivalent dose field obtained by the dose conversion of the first radiotherapy plan is obtained; wherein the equivalent dose field is used to evaluate the effect of radiotherapy on different radiation areas of the object to be radiotherapy;

[0009] The first equivalent dose field is used as a basic dose field to generate a second radiotherapy plan for the object to be radiotherapy in a second radiotherapy mode.

[0010] In some embodiments, using the first equivalent dose field as a basic dose field includes:

[0011] Get dose field selection operation;

[0012] When it is determined that the first equivalent dose field is selected between the original dose field and the first equivalent dose field of the first radiotherapy plan, the first equivalent dose field is used as the basic dose field.

[0013] In some embodiments, obtaining a dose field selection operation includes:

[0014] evaluating whether the original dose field of the first radiotherapy plan and the first equivalent dose field satisfy a first prescription condition;

[0015] The dose field selection operation is obtained based on an evaluation result of the evaluation.

[0016] In some embodiments, using the first equivalent dose field as a basic dose field, generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode includes:

[0017] In the case that the first equivalent dose field meets the first prescription condition, the first equivalent dose field is used as the basic dose field to generate a second radiotherapy plan for the object to be radiotreated in the second radiotherapy mode.

[0018] In some embodiments, when the first equivalent dose field does not satisfy the first prescription condition, after generating a second radiotherapy plan for the subject to be radiotherapy in the second radiotherapy mode using the first equivalent dose field as the basic dose field, the method further includes:

[0019] Determine a dose difference of a target radiation area in each radiation area corresponding to the first radiation therapy plan; the target radiation area refers to a radiation area that has not reached the prescription dose of the first radiation therapy mode; the dose difference represents the difference between the equivalent dose of the target radiation area and the prescription dose;

[0020] Based on the dose difference of the target radiation area, the equivalent dose of the target radiation area corresponding to the second radiotherapy plan is increased by a dose corresponding to the dose difference.

[0021] In some embodiments, using the first equivalent dose field as a basic dose field, generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode includes:

[0022] determining an objective function based on the prescription dose of the second radiotherapy mode;

[0023] The first equivalent dose field is used as the basic dose field, and reverse optimization is performed based on the objective function to obtain the second radiotherapy plan.

[0024] In some embodiments, in response to a dose conversion operation on the first radiotherapy plan, obtaining a first equivalent dose field obtained by dose conversion of the first radiotherapy plan includes:

[0025] In response to the dose conversion operation of the first radiotherapy plan, based on the radiation dose of each radiation area corresponding to the first radiotherapy plan, the fractionated radiation dose of each radiation area and the radiation sensitivity parameter corresponding to each radiation area, the equivalent dose corresponding to each radiation area is determined to obtain the first equivalent dose field.

[0026] In some embodiments, after generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode using the first equivalent dose field as a basic dose field, the method further comprises:

[0027] In response to a dose conversion operation on the second radiotherapy plan, acquiring a second equivalent dose field obtained by dose conversion of the second radiotherapy plan;

[0028] Based on the second equivalent dose field, it is evaluated whether the second radiotherapy plan satisfies the second prescription condition.

[0029] In some embodiments, in response to the dose conversion operation on the second radiotherapy plan, after acquiring a second equivalent dose field obtained by dose conversion of the second radiotherapy plan, the method further includes:

[0030] Superimposing the first equivalent dose field and the second equivalent dose field to obtain a comprehensive equivalent dose field of the first radiotherapy plan and the second radiotherapy plan;

[0031] Based on the comprehensive equivalent dose field, it is evaluated whether the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan meets the third prescription condition.

[0032] According to another aspect of the present disclosure, there is provided an electronic device, comprising:

[0033] at least one processor; and

[0034] a memory communicatively connected to the at least one processor; wherein,

[0035] The memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the method for generating a radiotherapy plan provided by the present disclosure.

[0036] According to another aspect of the present disclosure, a non-transitory computer-readable storage medium storing computer instructions is provided, wherein the computer instructions are used to enable the electronic device to execute the method for generating a radiotherapy plan provided by the present disclosure.

[0037] According to another aspect of the present disclosure, a computer program product is provided, including a computer program, which, when executed by a processor, implements the method for generating a radiotherapy plan provided by the present disclosure.

[0038] The technical solution provided by the present disclosure performs dose conversion on the first radiotherapy plan of the object to be radiotreated under the first radiotherapy mode to obtain the first equivalent dose field obtained by dose conversion of the first radiotherapy plan. Since the equivalent dose field can evaluate the impact of radiotherapy on different radiation areas in the object to be radiotreated, and then, using the first equivalent dose field as the basic dose field, it can be more convenient to generate the second radiotherapy plan of the object to be radiotreated under the second radiotherapy mode. In this way, in the case where the same object to be radiotreated corresponds to different radiotherapy modes, the radiotherapy plan of the object to be radiotreated under another radiotherapy mode can be formulated based on the existing radiotherapy plan of the object to be radiotreated under one radiotherapy mode. Moreover, formulating a new radiotherapy plan based on the equivalent dose field obtained by dose conversion of the existing radiotherapy plan as the basic dose field can effectively improve the accuracy of the generated radiotherapy plan.

[0039] It should be understood that the content described in this section is not intended to identify the key or important features of the embodiments of the present disclosure, nor is it intended to limit the scope of the present disclosure. Other features of the present disclosure will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The accompanying drawings are used to better understand the present solution and do not constitute a limitation of the present disclosure.

[0041] Figure 1 is a schematic diagram of an implementation environment of a method for generating a radiotherapy plan according to an embodiment of the present disclosure;

[0042] Figure 2 is a flow chart of a method for generating a radiotherapy plan according to an embodiment of the present disclosure;

[0043] Figure 3 is a flow chart of a method for generating a radiotherapy plan according to an embodiment of the present disclosure;

[0044] Figure 4 The block diagram of an electronic device used to implement the method for generating a radiotherapy plan according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0045] The following is a description of exemplary embodiments of the present disclosure in conjunction with the accompanying drawings, including various details of the embodiments of the present disclosure to facilitate understanding, which should be considered as merely exemplary. Therefore, it should be recognized by those of ordinary skill in the art that various changes and modifications may be made to the embodiments described herein without departing from the scope and spirit of the present disclosure. Similarly, for the sake of clarity and conciseness, descriptions of well-known functions and structures are omitted in the following description.

[0046] In the technical solution of the present disclosure, the collection, storage, use, processing, transmission, provision and disclosure of user personal information involved are in compliance with the provisions of relevant laws and regulations and do not violate public order and good morals.

[0047] First, the application scenarios involved in the embodiments of the present disclosure are described. The method for generating a radiotherapy plan provided in the embodiments of the present disclosure can be applied in the field of medical technology, and specifically can be applied in the scenario of radiotherapy.

[0048] With the rapid development of computer technology and imaging technology, radiotherapy technology has also become increasingly mature, such as Three Dimensional Conformal Radiation Therapy (3DCRT), Intensity Modulated Radiotherapy (IMRT), Volumetric Modulated Arc Therapy (VMAT), Image Guide Radiation Therapy (IGRT) and other radiotherapy technologies, the treatment accuracy is also getting higher and higher. By applying the above radiotherapy technologies, not only can a high dose be given to the tumor to improve the local control rate of the tumor, but also the dose irradiation of the surrounding normal tissue can be reduced to reduce the damage to the normal tissue.

[0049] In some embodiments, the same object to be radiotherapy may correspond to different radiotherapy modes. For example, for large tumors, a radiotherapy mode will be used for treatment, such as general irradiation treatment based on an accelerator, or a multi-fraction low-dose mode. For small tumors, another radiotherapy mode will be used for treatment, such as precision treatment based on a gamma knife, or a low-fraction high-dose mode. It should be understood that due to the characteristics of the accelerator and the gamma knife, the accelerator usually uses a multi-fraction low-dose mode for treatment, while the gamma knife usually uses a low-fraction high-dose mode for treatment. For patients with both large and small tumors, it is necessary to use a gamma knife to irradiate the small tumor, and then use an accelerator to irradiate the large tumor to achieve a better radiotherapy effect.

[0050] In order to ensure that a high dose is given to the tumor while normal tissue is not exposed to an excessive dose, a corresponding radiotherapy plan is usually formulated for the subject based on the prescribed dose of the subject to be radiotherapy. Therefore, when the subject to be radiotherapy corresponds to different radiotherapy modes, how to formulate a radiotherapy plan for the subject to be radiotherapy is a problem worthy of attention. Among them, the radiotherapy plan is a file used to control the radiotherapy equipment to deliver radiation.

[0051] Based on this, the disclosed embodiment provides a method for generating a radiotherapy plan, by performing dose conversion on a first radiotherapy plan of a subject to be radiotherapy under a first radiotherapy mode, so as to obtain a first equivalent dose field obtained by dose conversion of the first radiotherapy plan. Since the equivalent dose field can evaluate the impact of radiotherapy on different radiation areas in the subject to be radiotherapy, and then, using the first equivalent dose field as the basic dose field, it can be more convenient to generate a second radiotherapy plan for the subject to be radiotherapy under a second radiotherapy mode. In this way, in the case where the same subject to be radiotherapy corresponds to different radiotherapy modes, a radiotherapy plan for the subject to be radiotherapy under another radiotherapy mode can be formulated based on an existing radiotherapy plan for the subject to be radiotherapy under one radiotherapy mode. Moreover, formulating a new radiotherapy plan based on the equivalent dose field obtained by dose conversion of an existing radiotherapy plan as the basic dose field can effectively improve the accuracy of the generated radiotherapy plan.

[0052] Figure 1 is a schematic diagram of an implementation environment of a method for generating a radiotherapy plan shown in an embodiment of the present disclosure. Figure 1 The implementation environment includes an image acquisition device 101, a radiotherapy planning device 102, a control computer device 103 and a radiotherapy device 104.

[0053] The image acquisition device 101 is a device for acquiring the tumor site and surrounding normal tissue of the object to be radiotherapy (such as a patient). In some embodiments, the image acquisition device 101 can be at least one of a computed tomography (CT) device, an emission computed tomography (ECT) device, a magnetic resonance imaging (MRI) device, a positron emission tomography (PET) device, and an ultrasound examination device.

[0054] In the disclosed embodiment, the image acquisition device 101 is used to acquire medical images of the object to be radiotherapy, and upload the medical images of the object to be radiotherapy to the radiotherapy planning device 102, so that the radiotherapy planning device 102 performs a subsequent radiotherapy plan generation process based on the medical images of the object to be radiotherapy.

[0055] The radiotherapy planning device 102 is a device for formulating, optimizing and evaluating radiotherapy plans. The radiotherapy planning device 102 may run a radiotherapy planning system (TPS), which provides functions for formulating, optimizing and evaluating radiotherapy plans. For example, the RT pro TPS system. Furthermore, the radiotherapy planning system also provides an equivalent dose conversion function. For example, the equivalent dose conversion function may be an equivalent biological dose (EQD2) conversion function or a biologically effective dose (BED) conversion function.

[0056] In some embodiments, the radiotherapy planning device 102 may include a TPS client 1021 and a TPS server 1022 .

[0057] The TPS client 1021 may be at least one of a smart phone, a smart watch, a desktop computer, a laptop, a virtual reality terminal, an augmented reality terminal, a wireless terminal, a laptop, etc. For example, in some embodiments, the user can trigger the radiation therapy plan system running on the TPS server 1022 through the TPS client 1021 to perform dose conversion on the radiation therapy plan and display the equivalent dose field after dose conversion. In this way, the user's time can be effectively saved, and the converted equivalent dose field can be more intuitively presented so that the user can evaluate the radiation therapy plan.

[0058] Among them, the TPS server 1022 can be an independent physical server, or a server cluster or distributed file system composed of multiple physical servers, or at least one of the cloud servers that provide basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, content distribution networks, and big data or artificial intelligence platforms, etc., which is not limited in the embodiments of the present disclosure. In some embodiments, the number of the above-mentioned TPS servers 1022 can be more or less, which is not limited in the embodiments of the present disclosure. Of course, the TPS server 1022 can also include other functions to provide more comprehensive and diversified services. In some embodiments, the TPS server 1022 is used to provide background services for the above-mentioned TPS client 1021.

[0059] In the disclosed embodiment, the radiotherapy planning device 102 is used to obtain a first radiotherapy plan for the object to be radiotherapy under a first radiotherapy mode; in response to a dose conversion operation on the first radiotherapy plan, obtain a first equivalent dose field obtained by dose conversion of the first radiotherapy plan; and use the first equivalent dose field as a basic dose field to generate a second radiotherapy plan for the object to be radiotherapy under a second radiotherapy mode.

[0060] The control computer device 103 is a device for controlling the radiotherapy device 104 to execute the radiotherapy plan. In some embodiments, the control computer device 103 may include a host computer and a slave computer, the host computer is used to interact with the user, and the slave computer is used to control the movement of each moving part in the radiotherapy device 104. The host computer may be at least one of a smart phone, a smart watch, a desktop computer, a laptop computer, a virtual reality terminal, an augmented reality terminal, a wireless terminal, a laptop computer and / or a server device, and the slave computer may be a control device such as a programmable logic controller (PLC).

[0061] The radiotherapy device 104 is a device for performing radiotherapy on a subject to be treated (eg, a patient). In some embodiments, the radiotherapy device 104 may include a gantry 1041 , a first treatment head 1042 , a second treatment head 1043 , and a support device 1044 .

[0062] Among them, the rack 1041 can be a rotatable rack. The first treatment head 1042 and the second treatment head 1043 can be set on the rack to emit therapeutic rays, such as gamma rays, MV-level X-rays. For example, the first treatment head 1042 and the second treatment head 1043 can be any two of a gamma knife treatment head for rotational focused radiotherapy, an accelerator treatment head for conformal intensity modulated radiotherapy, or other radiotherapy heads. In the embodiment of the present disclosure, the first treatment head 1042 and the second treatment head 1043 can correspond to different radiotherapy modes, such as rotational focused radiotherapy and conformal intensity modulated radiotherapy. The support device 1014 is used to support and move the object to be radiotherapy, and can be a treatment bed.

[0063] In some embodiments, when the object to be radiotherapy is on the support device 1044, the rotation of the gantry 1041 can drive the first treatment head 1042 and the second treatment head 1043 to perform 360-degree irradiation around the object to be radiotherapy, thereby completing radiotherapy.

[0064] The following is based on Figure 1 The radiotherapy system constituted by the implementation environment shown is used to introduce the method provided by the embodiment of the present disclosure.

[0065] Figure 21 is a flow chart of a method for generating a radiotherapy plan shown in an embodiment of the present disclosure. In some embodiments, the method for generating a radiotherapy plan is executed by an electronic device. For example, the electronic device may be the above-mentioned Figure 1 The radiotherapy planning equipment shown. Figure 2 As shown, the method includes the following steps.

[0066] S201, obtaining a first radiotherapy plan for a subject to be radiotreated in a first radiotherapy mode.

[0067] The subject to be radiotherapy refers to a user to be treated with radiotherapy, such as a patient or a phantom used to simulate a patient. In the disclosed embodiment, the subject to be radiotherapy may correspond to different radiotherapy modes, and the scheme will be described below by taking the subject to be radiotherapy corresponding to the first radiotherapy mode and the second radiotherapy mode as an example.

[0068] Exemplarily, the first radiotherapy mode and the second radiotherapy mode can be determined based on different types of treatment heads of radiotherapy equipment, different types of radiotherapy modes, or radiotherapy plans between different fractions. For example, the first radiotherapy mode can be a rotational focusing radiotherapy mode (or a gamma knife mode), and the second radiotherapy mode can be an adaptive intensity modulated radiotherapy mode (or an accelerator mode). For another example, the first radiotherapy mode can be a low-fractionation, high-dose mode, and the second radiotherapy mode can be a multi-fractionation, low-dose mode. The disclosed embodiments do not limit the specific forms of the first radiotherapy mode and the second radiotherapy mode.

[0069] S202: In response to a dose conversion operation on the first radiotherapy plan, a first equivalent dose field obtained by dose conversion of the first radiotherapy plan is obtained.

[0070] In the disclosed embodiment, the equivalent dose field is used to evaluate the effect of radiotherapy on different radiation areas in the subject to be radiotherapy. Accordingly, the first equivalent dose field is used to evaluate the effect of radiotherapy based on the first radiotherapy plan on different radiation areas in the subject to be radiotherapy. The radiation area refers to biological tissue, such as an organ.

[0071] The equivalent dose field refers to the equivalent biological dose field, such as the EQD2 dose field, or the BED dose field. It should be understood that dose conversion refers to the conversion of different radiation doses into equivalent biological doses. In this way, the effects of different types of radiotherapy regimens on biological tissues can be better compared. Among them, the equivalent biological dose refers to the dose converted from the degree of cell damage after the organism is irradiated. For example, the larger the converted dose value, the greater the damage to the organism's cells.

[0072] It should be understood that a dose field refers to the radiation dose distribution used in radiotherapy, which is used to characterize the distribution of radiation energy released by radiation or other radiation sources in the human body. For example, the definition of a dose field may include aspects such as the intensity, position, and direction of the dose distribution. Typically, a dose field can be generated according to a radiotherapy plan and can be displayed or printed out using a computer image to help medical personnel (such as radiotherapists) accurately determine the delivery area and shape of the radiation dose, thereby ensuring the accuracy and safety of radiotherapy.

[0073] S203: Using the first equivalent dose field as a basic dose field, generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode.

[0074] The technical solution provided by the disclosed embodiment performs dose conversion on the first radiotherapy plan of the object to be radiotreated under the first radiotherapy mode to obtain the first equivalent dose field obtained by dose conversion of the first radiotherapy plan. Since the equivalent dose field can evaluate the impact of radiotherapy on different radiation areas in the object to be radiotreated, and then, using the first equivalent dose field as the basic dose field, it can be more convenient to generate the second radiotherapy plan of the object to be radiotreated under the second radiotherapy mode. In this way, in the case where the same object to be radiotreated corresponds to different radiotherapy modes, the radiotherapy plan of the object to be radiotreated under another radiotherapy mode can be formulated based on the existing radiotherapy plan of the object to be radiotreated under one radiotherapy mode. Moreover, formulating a new radiotherapy plan based on the equivalent dose field obtained by dose conversion of the existing radiotherapy plan as the basic dose field can effectively improve the accuracy of the generated radiotherapy plan.

[0075] Above Figure 2 This is a simple embodiment of the present disclosure. The following describes a method for generating a radiotherapy plan provided by the present disclosure based on a specific embodiment. Figure 3 1 is a flow chart of a method for generating a radiotherapy plan shown in an embodiment of the present disclosure. In some embodiments, the method for generating a radiotherapy plan is executed by an electronic device. For example, the electronic device may be the above-mentioned Figure 1 The radiotherapy planning equipment shown. Figure 3 As shown, with the radiotherapy planning device as the execution body, the method includes the following steps.

[0076] S301. A radiotherapy planning device obtains a first radiotherapy plan for a subject to be radiotherapy in a first radiotherapy mode.

[0077] The subject to be radiotherapy refers to a user to be treated with radiotherapy, such as a patient or a phantom used to simulate a patient. In the disclosed embodiment, the subject to be radiotherapy may correspond to different radiotherapy modes, and the scheme will be described below by taking the subject to be radiotherapy corresponding to the first radiotherapy mode and the second radiotherapy mode as an example.

[0078] Exemplarily, the first radiotherapy mode and the second radiotherapy mode can be determined based on different types of treatment heads of radiotherapy equipment, different types of radiotherapy modes, or radiotherapy plans between different fractions. For example, the first radiotherapy mode can be a gamma knife mode, and the second radiotherapy mode can be an accelerator mode. For another example, the first radiotherapy mode can be a low-fractionation high-dose mode, and the second radiotherapy mode can be a multi-fractionation low-dose mode. The disclosed embodiments do not limit the specific forms of the first radiotherapy mode and the second radiotherapy mode.

[0079] In some embodiments, the process of generating the first radiotherapy plan may refer to the following (1-1) to (1-3):

[0080] (1-1) The radiotherapy planning device acquires a medical image of the object to be radiotherapy.

[0081] The medical image is used to present the tumor site and surrounding normal tissue of the subject to be radiotherapy in the form of an image. For example, the medical image may include at least one of a CT scan image, a nuclear magnetic resonance scan image, or an ultrasound image.

[0082] In some embodiments, the process of the radiotherapy planning device acquiring the medical image of the object to be radiotherapy may refer to any one of the following two possible implementations.

[0083] In a possible implementation, after acquiring the medical image of the subject to be radiotherapy, the image acquisition device sends the medical image of the subject to be radiotherapy to the radiotherapy planning device. Accordingly, the radiotherapy planning device receives the medical image from the image acquisition device, that is, obtains the medical image of the subject to be radiotherapy.

[0084] In another possible implementation, after acquiring the medical image of the object to be radiotherapy, the image acquisition device outputs the medical image of the object to be radiotherapy. Exemplarily, the output medical image at this time may be in the form of a data packet file or in the form of a physical image. Then, the medical staff uploads the medical image output by the image acquisition device to the radiotherapy planning device, and the radiotherapy planning device also obtains the medical image of the object to be radiotherapy.

[0085] In the above embodiments, two implementation methods are provided for the radiotherapy planning device to obtain the medical image of the object to be radiotherapy, which improves the flexibility of obtaining the medical image. It is worth noting that in other embodiments, the radiotherapy planning device can also adopt other implementation methods to obtain the medical image of the object to be radiotherapy. The disclosed embodiments do not limit the process of obtaining the medical image.

[0086] (1-2) The radiotherapy planning device delineates the target area based on the medical image of the object to be radiotherapy to obtain a delineated image.

[0087] Among them, the outline image is used to characterize the contour of the target area or organ.

[0088] In some embodiments, after the radiotherapy planning device acquires the medical image of the object to be radiotherapy, it automatically delineates the target area based on the medical image of the object to be radiotherapy to obtain a delineated image.

[0089] Alternatively, in other embodiments, after the radiotherapy planning device acquires the medical image of the object to be radiotherapy, the medical image of the object to be radiotherapy is displayed, and medical personnel delineate the target area based on the medical image of the object to be radiotherapy to obtain a delineated image.

[0090] In the above embodiments, two methods are provided: the radiotherapy planning device automatically delineates the target area and the medical staff manually delineates the target area, which improves the flexibility of obtaining the delineated image. It is worth noting that in other embodiments, the radiotherapy planning device can also use other implementation methods to perform target area delineation to obtain the delineated image. The disclosed embodiments do not limit the acquisition process of the delineated image.

[0091] (1-3) The radiotherapy planning device creates a first radiotherapy plan based on the outline image, determines an objective function based on the prescription dose of the first radiotherapy mode, and then performs reverse optimization based on the objective function to obtain the first radiotherapy plan.

[0092] In some embodiments, after the radiotherapy planning device creates a new first radiotherapy plan based on the delineated image, it can determine the dose and volume histogram (DVH) corresponding to the first radiotherapy mode based on the prescription dose of the first radiotherapy mode. Then, the dose and volume histogram is used as the objective function for reverse optimization to obtain the first radiotherapy plan.

[0093] The dose volume histogram is used to characterize how much volume within the target area and organ is irradiated at what dose level.

[0094] Alternatively, in some other embodiments, after the radiotherapy planning device creates a new first radiotherapy plan based on the delineated image, it can determine the dose distribution (Dose) corresponding to the first radiotherapy mode based on the prescription dose of the first radiotherapy mode. Then, the dose distribution is used as the objective function for reverse optimization to obtain the first radiotherapy plan.

[0095] The dose distribution is used to characterize the dose distribution of different parts of the target area of ​​the object to be radiotherapy. For example, the reference dose distribution can be in the form of an image, a table or a curve. Exemplarily, taking the form of an image as an example, the reference dose distribution can be a three-dimensional dose distribution map.

[0096] Alternatively, in some other embodiments, after the radiotherapy planning device creates a new first radiotherapy plan based on the delineated image, it can determine the flux map corresponding to the first radiotherapy mode based on the prescription dose of the first radiotherapy mode, and then use the flux map as the objective function for reverse optimization to obtain the first radiotherapy plan.

[0097] The flux map is used to characterize the intensity distribution of the radiation emitted by the radiotherapy equipment at different positions (x, y) in the target area of ​​the object to be radiotherapy.

[0098] The above-mentioned process of optimizing the first radiotherapy plan is described by taking the reverse optimization based on the dose volume histogram, dose distribution or flux map as an example. It should be noted that the radiotherapy planning device can also perform the process of optimizing the first radiotherapy plan based on two or three items in the dose volume histogram, dose distribution or flux map. The embodiments of the present disclosure are not limited to this. It is worth noting that in other embodiments, the radiotherapy planning device can also use other implementation methods to perform the process of optimizing the first radiotherapy plan. The embodiments of the present disclosure are not limited to the process of reverse optimization.

[0099] It should be noted that the first radiotherapy plan can be generated in real time when the present scheme is implemented. For example, when the present scheme is implemented, the first radiotherapy plan of the object to be radiotherapy in the first radiotherapy mode is obtained through the above (1-1) to (1-3). Alternatively, the first radiotherapy plan can also be generated in advance before the implementation of the present scheme. For example, a radiotherapy plan record can be maintained in the radiotherapy planning device, and the radiotherapy plan record is used to store the generated radiotherapy plans for multiple objects to be radiotherapy. When the present scheme is implemented, the radiotherapy planning device can obtain the radiotherapy plan corresponding to the identifier of the object to be radiotherapy from the radiotherapy plan record based on the identifier of the object to be radiotherapy, as the first radiotherapy plan. Among them, the identifier of the object to be radiotherapy can be a name, a number or an identity identification number (Identity Document, ID).

[0100] S302: The radiotherapy planning device obtains a first equivalent dose field obtained by dose conversion of the first radiotherapy plan in response to a dose conversion operation on the first radiotherapy plan.

[0101] In the disclosed embodiment, the equivalent dose field is used to evaluate the effect of radiotherapy on different radiation areas in the subject to be radiotherapy. Accordingly, the first equivalent dose field is used to evaluate the effect of radiotherapy based on the first radiotherapy plan on different radiation areas in the subject to be radiotherapy. The radiation area refers to biological tissue, such as an organ.

[0102] The equivalent dose field refers to the equivalent biological dose field, such as the EQD2 dose field, or the BED dose field. It should be understood that dose conversion refers to the conversion of different radiation doses into equivalent biological doses. In this way, the effects of different types of radiotherapy regimens on biological tissues can be better compared. Among them, the equivalent biological dose refers to the dose converted from the degree of cell damage after the organism is irradiated. For example, the larger the converted dose value, the greater the damage to the organism's cells.

[0103] It should be understood that a dose field refers to the radiation dose distribution used in radiotherapy, which is used to characterize the distribution of radiation energy released by radiation or other radiation sources in the human body. For example, the definition of a dose field may include aspects such as the intensity, position, and direction of the dose distribution. Typically, a dose field can be generated according to a radiotherapy plan and can be displayed or printed out using a computer image to help medical personnel (such as radiotherapists) accurately determine the delivery area and shape of the radiation dose, thereby ensuring the accuracy and safety of radiotherapy.

[0104] In some embodiments, a dose conversion function control may be provided in the display interface of the radiotherapy planning device, and the medical staff can trigger the dose conversion operation of the first radiotherapy plan by performing a trigger operation on the dose conversion function control, so that the radiotherapy planning device can subsequently perform the dose conversion process. The trigger operation may be any one of a click operation, a long press operation, a double click operation, or a hover operation.

[0105] In some embodiments, the radiotherapy planning device responds to the dose conversion operation of the first radiotherapy plan, determines the equivalent dose corresponding to each radiation area based on the radiation dose of each radiation area corresponding to the first radiotherapy plan, the fractionated radiation dose of each radiation area, and the radiation sensitivity parameters corresponding to each radiation area, and obtains the first equivalent dose field.

[0106] Among them, the radiation dose of each radiation area refers to the total radiation dose of each radiation area, such as the total radiation dose of each organ. In some embodiments, the radiation dose of each radiation area can be determined based on the original dose field of the first radiotherapy plan. The fractionated radiation dose of each radiation area can be set by medical personnel before implementing this scheme. The radiation sensitivity parameters corresponding to each radiation area can be determined based on a preset sensitivity constant table, such as an organ sensitivity constant table. Among them, the sensitivity constant table is used to record the radiation sensitivity parameters corresponding to the identifications of different radiation areas (such as organs). For example, based on the identifications of each radiation area corresponding to the first radiotherapy plan, the radiation sensitivity parameters corresponding to the identifications of each radiation area are determined from the sensitivity constant table to obtain the radiation sensitivity parameters corresponding to each radiation area.

[0107] Exemplarily, taking the first equivalent dose field as the EQD2 dose field as an example, the dose conversion process may be: based on the radiation dose of each radiation area corresponding to the first radiotherapy plan, the fractionated radiation dose of each radiation area, the radiation sensitivity parameter corresponding to each radiation area and the following formula (1), determine the equivalent dose corresponding to each radiation area to obtain the first equivalent dose field.

[0108] EQD2=D*(d+α / β) / (2+α / β) (1)

[0109] In the formula, EQD2 represents the equivalent dose corresponding to the radiation area; D represents the radiation dose of the radiation area; d represents the fractionated radiation dose of the radiation area; α / β represents the radiation sensitivity parameter corresponding to the radiation area; it should be understood that α / β is different for different radiation areas; 2 represents the dose converted to 2 Gy (Gray) per fraction, which can also be set to other values.

[0110] Thus, based on the above formula (1), the equivalent dose corresponding to each radiation area can be determined, thereby obtaining the first equivalent dose field. At this time, the radiotherapy plan corresponding to the first equivalent dose field can be called the EQD2 plan.

[0111] Furthermore, in some embodiments, after the radiotherapy planning device acquires the first equivalent dose field obtained by dose conversion of the first radiotherapy plan, the first equivalent dose field can be displayed so that subsequent medical personnel can view the converted first equivalent dose field more intuitively.

[0112] S303: The radiotherapy planning device evaluates whether the original dose field and the first equivalent dose field of the first radiotherapy plan satisfy the first prescription condition.

[0113] Wherein, the first prescription condition is used to evaluate the quality of the original dose field and the first equivalent dose field. In some embodiments, the first prescription condition can be set to a target area coverage greater than a preset coverage rate. Wherein, the target area coverage rate refers to the ratio of the target area volume that reaches the prescription dose to the total volume of the target area. The preset coverage rate may be the target area coverage rate required by the prescription. For example, the preset coverage rate may be 95%, indicating that the ratio of the target area volume that reaches the prescription dose to the total volume of the target area must reach 95%. It should be understood that a target area coverage rate of a radiotherapy plan greater than the preset coverage rate indicates that the radiotherapy plan meets the first prescription condition. A target area coverage rate of a radiotherapy plan less than or equal to the preset coverage rate indicates that the radiotherapy plan does not meet the first prescription condition.

[0114] In some embodiments, the radiotherapy planning device determines the target area coverage rate corresponding to the original dose field based on the original dose field of the first radiotherapy plan, and determines the target area coverage rate corresponding to the first equivalent dose field based on the first equivalent dose field. Furthermore, by judging whether the target area coverage rate of the first equivalent dose field and the original dose field is greater than the preset coverage rate, it is evaluated whether the original dose field and the first equivalent dose field meet the first prescription condition.

[0115] Furthermore, in some embodiments, the radiotherapy planning device may display the evaluation result of the evaluation so that subsequent medical personnel can view the evaluation result of the evaluation more intuitively and implement the dose field selection operation based on the evaluation result.

[0116] S304: The radiotherapy planning device obtains a dose field selection operation based on the evaluation result of the evaluation.

[0117] The dose field selection operation refers to an operation of selecting a dose field. For example, the dose field selection operation may be an operation for indicating that the first equivalent dose field has been selected, or the dose field selection operation may be an operation for indicating that the original dose field of the first radiotherapy plan has been selected.

[0118] In some embodiments, when the evaluation result indicates that the first equivalent dose field meets the first prescription condition, the radiotherapy planning device obtains an operation for indicating that the first equivalent dose field has been selected, and then performs a subsequent process of generating a second radiotherapy plan based on the selected first equivalent dose field.

[0119] Alternatively, in some other embodiments, the radiotherapy planning device obtains an operation for indicating the original dose field of the selected first radiotherapy plan when the evaluation result indicates that the original dose field of the first radiotherapy plan satisfies the first prescription condition, and then performs a subsequent process of generating a second radiotherapy plan based on the original dose field of the selected first radiotherapy plan.

[0120] S305: When the radiotherapy planning device determines that the first equivalent dose field is selected between the original dose field and the first equivalent dose field of the first radiotherapy plan, the first equivalent dose field is used as the basic dose field.

[0121] The basic dose field can also be called the background dose field. For example, if the basic dose field is 20-20-20, and the dose required by the prescription is 100-100-100, then it is necessary to optimize the plan based on the basic dose field 20-20-20 so that the dose reaches 100-100-100. Of course, if the basic dose field is not set, it is necessary to optimize the plan based on 0-0-0 so that the dose reaches 100-100-100.

[0122] The above S305 takes the case of selecting the first equivalent dose field as an example. In other embodiments, when the radiotherapy planning device determines that the original dose field is selected between the original dose field of the first radiotherapy plan and the first equivalent dose field, the original dose field is used as the basic dose field.

[0123] The embodiments shown in S304 to S305 above take the process of determining the basic dose field based on the dose field selection operation as an example to illustrate the scheme. After obtaining the evaluation result of the evaluation based on S303, the medical staff can analyze the evaluation result based on the evaluation and perform the dose field selection operation in the interface of the radiotherapy planning device to determine the selected basic dose field.

[0124] In other embodiments, after obtaining the evaluation result of the evaluation based on S303, the radiotherapy planning device can also automatically select the basic dose field. The corresponding process can be: the radiotherapy planning device responds to the evaluation result indicating that the first equivalent dose field meets the first prescription condition, and automatically uses the first equivalent dose field as the basic dose field. Alternatively, the radiotherapy planning device responds to the evaluation result indicating that the original dose field of the first radiotherapy plan meets the first prescription condition, and automatically uses the original dose field as the basic dose field. In this way, the automatic selection of the basic dose field is achieved, and the efficiency of human-computer interaction is improved.

[0125] S306: The radiotherapy planning device generates a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode.

[0126] In the embodiment shown in S305 to S306 above, the radiotherapy planning device uses the first equivalent dose field as the basic dose field to generate a second radiotherapy plan for the object to be radiotherapy in the second radiotherapy mode.

[0127] In some embodiments, the second radiotherapy plan generation process may be: creating a new second radiotherapy plan, and determining an objective function based on the prescription dose of the second radiotherapy mode. Then, using the first equivalent dose field as the basic dose field, performing inverse optimization based on the objective function to obtain the second radiotherapy plan.

[0128] In a possible implementation, after creating a new second radiotherapy plan, the radiotherapy planning device can determine a dose-volume histogram corresponding to the second radiotherapy mode based on the prescription dose of the second radiotherapy mode, and then use the dose-volume histogram as an objective function for reverse optimization to obtain the second radiotherapy plan.

[0129] Alternatively, in another possible implementation, after creating the second radiotherapy plan, the radiotherapy planning device can determine the dose distribution corresponding to the second radiotherapy mode based on the prescription dose of the second radiotherapy mode, and then use the dose distribution as the objective function for reverse optimization to obtain the second radiotherapy plan.

[0130] Alternatively, in another possible implementation, after creating the second radiotherapy plan, the radiotherapy planning device can determine the flux map corresponding to the second radiotherapy mode based on the prescription dose of the second radiotherapy mode, and then use the flux map as the objective function for reverse optimization to obtain the second radiotherapy plan.

[0131] The above-mentioned process of optimizing the second radiotherapy plan is described by taking the reverse optimization based on the dose volume histogram, dose distribution or flux map as an example. It should be noted that the radiotherapy planning device can also perform the process of optimizing the second radiotherapy plan based on two or three items in the dose volume histogram, dose distribution or flux map. The embodiments of the present disclosure are not limited to this. It is worth noting that in other embodiments, the radiotherapy planning device can also use other implementation methods to perform the process of optimizing the second radiotherapy plan. The embodiments of the present disclosure are not limited to the process of reverse optimization.

[0132] In addition, it should be noted that the above steps S303 to S305 are optional steps. In some embodiments, after the radiotherapy planning device obtains the first equivalent dose field based on S302, it is not necessary to perform the above steps S303 to S305, and automatically uses the first equivalent dose field as the basic dose field. In this embodiment, the first equivalent dose field may not meet the first prescription condition. At this time, the first radiotherapy plan can be reverse optimized until the first equivalent dose field meets the first prescription condition, and then the process of generating the second radiotherapy plan is performed based on the first radiotherapy plan that meets the first prescription condition.

[0133] Alternatively, when the first equivalent dose field does not meet the first prescription condition, the subsequent process of generating the second radiotherapy plan can also be performed. At this time, the first radiotherapy plan can be supplemented during the optimization process of the second radiotherapy plan. The corresponding process may be: the radiotherapy planning device determines the dose difference of the target radiation area among the radiation areas corresponding to the first radiotherapy plan. Based on the dose difference of the target radiation area, the equivalent dose of the target radiation area corresponding to the second radiotherapy plan is increased by the dose corresponding to the dose difference. Among them, the target radiation area refers to the radiation area that has not reached the prescription dose of the first radiotherapy mode. The dose difference represents the difference between the equivalent dose of the target radiation area and the prescription dose. In this way, the accuracy of generating the radiotherapy plan can be guaranteed.

[0134] S307: The radiotherapy planning device obtains a second equivalent dose field obtained by dose conversion of the second radiotherapy plan in response to the dose conversion operation on the second radiotherapy plan.

[0135] In some embodiments, a display interface of the radiotherapy planning device may provide a functional control for dose conversion. Medical personnel can trigger the dose conversion operation of the second radiotherapy plan by triggering the functional control for dose conversion, so that the radiotherapy planning device can subsequently perform the dose conversion process.

[0136] In some embodiments, the radiotherapy planning device responds to the dose conversion operation of the second radiotherapy plan, determines the equivalent dose corresponding to each radiation area based on the radiation dose of each radiation area corresponding to the second radiotherapy plan, the fractionated radiation dose of each radiation area, and the radiation sensitivity parameters corresponding to each radiation area, and obtains the second equivalent dose field.

[0137] The radiation dose of each radiation area refers to the total radiation dose of each radiation area. In some embodiments, the radiation dose of each radiation area can be determined based on the original dose field of the second radiotherapy plan. The fractionated radiation dose of each radiation area can be set by medical personnel before implementing this scheme. The radiation sensitivity parameters corresponding to each radiation area can be determined based on a preset sensitivity constant table, such as an organ sensitivity constant table.

[0138] Furthermore, in some embodiments, after the radiotherapy planning device acquires the second equivalent dose field obtained by dose conversion of the second radiotherapy plan, the second equivalent dose field can be displayed so that subsequent medical personnel can view the converted second equivalent dose field more intuitively.

[0139] S308. The radiotherapy planning device evaluates whether the second radiotherapy plan satisfies the second prescription condition based on the second equivalent dose field.

[0140] Among them, the second prescription condition is used to evaluate the quality of the second radiotherapy plan. For example, the second prescription condition can be the same as the first prescription condition, and both are set to target area coverage greater than the preset coverage. Alternatively, the second prescription condition can also be set to other conditions, such as the target isocenter is the same as the device isocenter, the target arcing angle and the device arcing angle are the same (or included), the device speed (i.e., the machine speed) meets the target irradiation time, the device speed meets the device arcing irradiation time, etc. The present disclosed embodiment does not limit the setting of the second prescription condition.

[0141] In some embodiments, when the second radiotherapy mode of the subject to be radiotherapy is a preset radiotherapy mode, the above S307 to S308 are performed to evaluate the second radiotherapy mode. For example, taking the preset radiotherapy mode as a high-dose low-fractionated dose mode of an accelerator as an example, when the second radiotherapy mode of the subject to be radiotherapy is a high-dose low-fractionated dose mode of an accelerator, the above S307 to S308 are performed to evaluate the second radiotherapy mode.

[0142] Furthermore, if the second radiotherapy plan meets the second prescription condition, the second radiotherapy plan is output. If the second radiotherapy plan does not meet the second prescription condition, the second radiotherapy plan can be reversely optimized until the second radiotherapy plan meets the second prescription condition, and then the second radiotherapy plan is output.

[0143] It should be noted that the above steps S307 to S308 are optional steps. In some embodiments, after the second radiotherapy plan is generated based on S306, there is no need to perform S307 to S308, and the second radiotherapy plan is directly output.

[0144] In some embodiments, after obtaining the second equivalent dose field obtained by dose conversion of the second radiotherapy plan, the first radiotherapy plan and the second radiotherapy plan can also be comprehensively evaluated, and the corresponding process can be: superimposing the first equivalent dose field and the second equivalent dose field to obtain a comprehensive equivalent dose field of the first radiotherapy plan and the second radiotherapy plan. Based on the comprehensive equivalent dose field, whether the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan meets the third prescription condition is evaluated. Among them, the setting of the third prescription condition is similar to the second prescription condition and will not be repeated.

[0145] Furthermore, if the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan meets the third prescription condition, the second radiotherapy plan is output. If the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan does not meet the third prescription condition, the second radiotherapy plan can be reversely optimized until the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan meets the third prescription condition, and then the second radiotherapy plan is output.

[0146] In the embodiment of the present disclosure, by providing an equivalent dose conversion function in the radiotherapy planning system, and then by dose conversion, combining the first equivalent dose field with the second equivalent dose field, it is possible to more quickly and conveniently evaluate the dose effect of the mixed radiotherapy of the two radiotherapy plans, thereby improving the treatment effect. Compared with the related art in which the user manually calculates the equivalent dose or uses a third-party tool to calculate the equivalent dose, the embodiment of the present disclosure greatly improves the efficiency of dose conversion.

[0147] Exemplarily, the first radiotherapy mode and the second radiotherapy mode correspond to different treatment heads of the radiotherapy equipment, for example, the first radiotherapy mode corresponds to a gamma knife treatment head, and the second radiotherapy mode corresponds to an accelerator treatment head. The process of formulating an accelerator gamma knife hybrid radiotherapy plan (or a double-head plan) can be: first, the patient data such as medical images and outline images required for making the radiotherapy plan are imported into the radiotherapy planning equipment, and the gamma knife plan is made in combination with the gamma knife prescription dose set by the medical staff. Then, after the dose conversion is performed based on the gamma knife plan to obtain the equivalent dose field of the gamma knife plan, the equivalent dose field of the gamma knife plan is used as the background dose field (i.e., the basic dose field) to generate the accelerator plan. Then, the gamma plan and the accelerator plan are superimposed and the double-head plan is output. In this way, a double-head plan formulation process is provided. Among them, when determining the background dose field, the dose conversion of the gamma knife plan can be directly performed and converted into intuitive dose field data for medical personnel to evaluate, so that medical personnel can more quickly evaluate the radiotherapy effects of the original dose field and equivalent dose field of the gamma knife plan, and thus select the one with good radiotherapy effect as the local dose field to prepare the accelerator plan.

[0148] The technical solution provided by the disclosed embodiment performs dose conversion on the first radiotherapy plan of the object to be radiotreated under the first radiotherapy mode to obtain the first equivalent dose field obtained by dose conversion of the first radiotherapy plan. Since the equivalent dose field can evaluate the impact of radiotherapy on different radiation areas in the object to be radiotreated, and then, using the first equivalent dose field as the basic dose field, it can be more convenient to generate the second radiotherapy plan of the object to be radiotreated under the second radiotherapy mode. In this way, in the case where the same object to be radiotreated corresponds to different radiotherapy modes, the radiotherapy plan of the object to be radiotreated under another radiotherapy mode can be formulated based on the existing radiotherapy plan of the object to be radiotreated under one radiotherapy mode. Moreover, formulating a new radiotherapy plan based on the equivalent dose field obtained by dose conversion of the existing radiotherapy plan as the basic dose field can effectively improve the accuracy of the generated radiotherapy plan.

[0149] According to an embodiment of the present disclosure, the present disclosure also provides an electronic device, comprising at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor so that the at least one processor can execute the method for generating a radiotherapy plan provided by the present disclosure.

[0150] According to an embodiment of the present disclosure, the present disclosure further provides a non-transitory computer-readable storage medium storing computer instructions, wherein the computer instructions are used to enable an electronic device to execute the method for generating a radiotherapy plan provided by the present disclosure.

[0151] According to an embodiment of the present disclosure, the present disclosure further provides a computer program product, including a computer program, which, when executed by a processor, implements the method for generating a radiotherapy plan provided by the present disclosure.

[0152] In some embodiments, the electronic device may be the above Figure 1 The radiation therapy planning device shown in . Figure 4 A schematic block diagram of an example electronic device 400 that can be used to implement an embodiment of the present disclosure is shown. The electronic device 400 is intended to represent various forms of digital computers, such as laptop computers, desktop computers, workstations, personal digital assistants, servers, blade servers, mainframe computers, and other suitable computers. The electronic device 400 can also represent various forms of mobile devices, such as personal digital processing, cellular phones, smart phones, wearable devices, and other similar computing devices. The components shown herein, their connections and relationships, and their functions are merely examples and are not intended to limit the implementation of the present disclosure described and / or required herein.

[0153] like Figure 4 As shown, the electronic device 400 includes a computing unit 401, which can perform various appropriate actions and processes according to a computer program stored in a read-only memory (ROM) 402 or a computer program loaded from a storage unit 408 to a random access memory (RAM) 403. In RAM 403, various programs and data required for the operation of the electronic device 400 can also be stored. The computing unit 401, ROM 402 and RAM 403 are connected to each other via a bus 404. An input / output (I / O) interface 405 is also connected to the bus 404.

[0154] Multiple components in the electronic device 400 are connected to the I / O interface 405, including: an input unit 406, such as a keyboard, a mouse, etc.; an output unit 407, such as various types of displays, speakers, etc.; a storage unit 408, such as a disk, an optical disk, etc.; and a communication unit 409, such as a network card, a modem, a wireless communication transceiver, etc. The communication unit 409 allows the electronic device 400 to exchange information / data with other devices through a computer network such as the Internet and / or various telecommunication networks.

[0155] The computing unit 401 may be a variety of general and / or special processing components with processing and computing capabilities. Some examples of the computing unit 401 include, but are not limited to, a central processing unit (CPU), a graphics processing unit (GPU), various dedicated artificial intelligence (AI) computing chips, various computing units running machine learning model algorithms, digital signal processors (DSP), and any appropriate processors, controllers, microcontrollers, etc. The computing unit 401 performs the various methods and processes described above, such as the method for generating a radiotherapy plan. For example, in some embodiments, the method for generating a radiotherapy plan may be implemented as a computer software program, which is tangibly contained in a machine-readable medium, such as a storage unit 408. In some embodiments, part or all of the computer program may be loaded and / or installed on the electronic device 400 via the ROM 402 and / or the communication unit 409. When the computer program is loaded into the RAM 403 and executed by the computing unit 401, one or more steps of the method for generating a radiotherapy plan described above may be performed. Alternatively, in other embodiments, the computing unit 401 may be configured to execute the method for generating a radiotherapy plan in any other appropriate manner (for example, by means of firmware).

[0156] Various embodiments of the systems and techniques described above herein can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), application specific standard parts (ASSPs), system on chip systems (SOCs), complex programmable logic devices (CPLDs), computer hardware, firmware, software, and / or combinations thereof. These various embodiments may include: being implemented in one or more computer programs, which may be executed and / or interpreted on a programmable system including at least one programmable processor, which may be a dedicated or general programmable processor, which may receive data and instructions from a storage system, at least one input device, and at least one output device, and transmit data and instructions to the storage system, the at least one input device, and the at least one output device.

[0157] The program code for implementing the method of the present disclosure may be written in any combination of one or more programming languages. These program codes may be provided to a processor or controller of a general-purpose computer, a special-purpose computer, or other programmable data processing device, so that the program code, when executed by the processor or controller, enables the functions / operations specified in the flow chart and / or block diagram to be implemented. The program code may be executed entirely on the machine, partially on the machine, partially on the machine and partially on a remote machine as a stand-alone software package, or entirely on a remote machine or server.

[0158] In the context of the present disclosure, a machine-readable medium may be a tangible medium that may contain or store a program for use by or in conjunction with an instruction execution system, device, or equipment. A machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or equipment, or any suitable combination of the foregoing. A more specific example of a machine-readable storage medium may include an electrical connection based on one or more lines, a portable computer disk, a hard disk, a random access memory, a read-only memory, an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0159] To provide interaction with a user, the systems and techniques described herein can be implemented on a computer having: a display device for displaying information to the user, such as a cathode ray tube (CRT) or a liquid crystal display (LCD) monitor; and a keyboard and a pointing device (e.g., a mouse or a trackball), through which the user can provide input to the computer. Other types of devices can also be used to provide interaction with the user; for example, the feedback provided to the user can be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and the input from the user can be received in any form (including acoustic input, voice input, or tactile input).

[0160] The systems and techniques described herein can be implemented in a computing system that includes back-end components (e.g., as a data server), or a computing system that includes middleware components (e.g., an application server), or a computing system that includes front-end components (e.g., a user computer with a graphical user interface or a web browser through which a user can interact with implementations of the systems and techniques described herein), or a computing system that includes any combination of such back-end components, middleware components, or front-end components. The components of the system can be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: Local Area Networks (LANs), Wide Area Networks (WANs), and the Internet.

[0161] A computer system may include a client and a server. The client and the server are generally remote from each other and usually interact through a communication network. The relationship of client and server is generated by computer programs running on respective computers and having a client-server relationship with each other. The server may be a cloud server, a server of a distributed system, or a server combined with a blockchain.

[0162] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps recorded in this disclosure can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution of this disclosure can be achieved, and this document is not limited here.

[0163] The above specific implementations do not constitute a limitation on the protection scope of the present disclosure. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present disclosure shall be included in the protection scope of the present disclosure.

Claims

1. A method for generating a radiotherapy plan, characterized in that: include: Obtaining a first radiotherapy plan for the subject to be radiotreated under a first radiotherapy mode; In response to the dose conversion operation on the first radiotherapy plan, a first equivalent dose field obtained by the dose conversion of the first radiotherapy plan is acquired; wherein the equivalent dose field is used to evaluate the effect of radiotherapy on different radiation areas of the object to be radiotherapy; A second radiotherapy plan for the object to be radiotreated in a second radiotherapy mode is generated using the first equivalent dose field as a basic dose field.

2. The method according to claim 1, characterized in that The method of taking the first equivalent dose field as a basic dose field comprises: Get dose field selection operation; When it is determined that the first equivalent dose field is selected between the original dose field and the first equivalent dose field of the first radiotherapy plan, the first equivalent dose field is used as the basic dose field.

3. The method according to claim 2, characterized in that The step of obtaining a dose field selection operation includes: evaluating whether the original dose field of the first radiotherapy plan and the first equivalent dose field satisfy a first prescription condition; The dose field selection operation is acquired based on an evaluation result of the evaluating.

4. The method according to claim 3, characterized in that The step of generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode by using the first equivalent dose field as a basic dose field comprises: In a case where the first equivalent dose field satisfies the first prescription condition, a second radiotherapy plan for the object to be radiotreated in the second radiotherapy mode is generated by taking the first equivalent dose field as the basic dose field.

5. The method according to claim 3, characterized in that: In the case that the first equivalent dose field does not satisfy the first prescription condition, after generating a second radiotherapy plan for the subject to be radiotreated in a second radiotherapy mode by using the first equivalent dose field as a basic dose field, the method further includes: Determine a dose difference of a target radiation area in each radiation area corresponding to the first radiotherapy plan; the target radiation area refers to a radiation area that has not reached the prescription dose of the first radiotherapy mode; the dose difference represents the difference between the equivalent dose of the target radiation area and the prescription dose; Based on the dose difference of the target radiation area, the equivalent dose of the target radiation area corresponding to the second radiotherapy plan is increased by a dose corresponding to the dose difference.

6. The method according to any one of claims 1 to 5, characterized in that The step of generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode by using the first equivalent dose field as a basic dose field comprises: determining an objective function based on the prescription dose of the second radiotherapy mode; The first equivalent dose field is used as the basic dose field, and inverse optimization is performed based on the objective function to obtain the second radiotherapy plan.

7. The method according to claim 1, characterized in that The step of acquiring, in response to the dose conversion operation on the first radiotherapy plan, a first equivalent dose field obtained by dose conversion of the first radiotherapy plan comprises: In response to the dose conversion operation of the first radiotherapy plan, based on the radiation dose of each radiation area corresponding to the first radiotherapy plan, the fractionated radiation dose of each radiation area and the radiation sensitivity parameter corresponding to each radiation area, the equivalent dose corresponding to each radiation area is determined to obtain the first equivalent dose field.

8. The method according to claim 1, characterized in that After generating a second radiotherapy plan for the subject to be radiotherapy in a second radiotherapy mode by using the first equivalent dose field as a basic dose field, the method further comprises: In response to a dose conversion operation on the second radiotherapy plan, acquiring a second equivalent dose field obtained by dose conversion of the second radiotherapy plan; Based on the second equivalent dose field, whether the second radiotherapy plan satisfies a second prescription condition is evaluated.

9. The method according to claim 8, characterized in that After obtaining a second equivalent dose field obtained by dose conversion of the second radiotherapy plan in response to the dose conversion operation on the second radiotherapy plan, the method further includes: superimposing the first equivalent dose field and the second equivalent dose field to obtain a comprehensive equivalent dose field of the first radiotherapy plan and the second radiotherapy plan; Based on the comprehensive equivalent dose field, an evaluation is performed on whether the comprehensive treatment effect of the first radiotherapy plan and the second radiotherapy plan meets a third prescription condition.

10. An electronic device, characterized in that: include: at least one processor; as well as a memory communicatively connected to the at least one processor; wherein, The memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the method according to any one of claims 1 to 9.

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