Celery seeds for bone development

Abstract

The present invention discloses the application of celery seeds in promoting bone development, which is specifically manifested in that the calcium and phosphorus elements contained in celery seeds can promote bone development, have a synergistic effect in promoting adolescent bone development, enhance the absorption of trace elements that are beneficial to bone development, and can also prevent the occurrence of rickets during adolescence to a certain extent. Its mechanism of action is that celery seeds are rich in calcium and phosphorus, which are both necessary elements for bone development. At the same time, the calcium and phosphorus elements rich in celery seeds can prevent osteoporosis caused by bone calcium and phosphorus deficiency for the elderly. In addition, celery seeds can also enhance bone density, improve its toughness, and further improve the overall comprehensive level of bones. Celery seeds are also a dual-purpose crop for medicine and food, are easy to obtain, and have no toxic side effects, which is conducive to widespread use.

Description

Technical Field

[0001] The invention relates to application of celery seeds in promoting bone development, and in particular to the field of health food promoting bone development. Background Art

[0002] Bones are the framework of human growth and are closely related to our growth and health. At present, bone development mainly includes drug intervention and non-drug intervention. Drug intervention is to supplement the elements required for bone development through drugs; non-drug intervention is to promote bone development by changing lifestyle and daily supplementation of nutrients. With the continuous progress of research and the continuous development of treatment methods, drugs can indeed improve bone development to a certain extent, but some people will still have adverse reactions.

[0003] In order to achieve a better application in promoting bone development, the present invention has found that celery seeds are rich in calcium and phosphorus, which can be well absorbed by the human body and converted into what is needed for bone growth, thereby alleviating problems such as slow bone development caused by malnutrition in the human body. Summary of the invention

[0004] In order to solve the above problems, the present invention provides celery seeds, a natural plant fruit that promotes bone development. In order to better reflect the effectiveness of celery seeds in bone development, the inventor and his team developed the following embodiments:

[0005] The present invention discovered celery seeds through research and found that they are rich in calcium and phosphorus. Calcium and phosphorus are both essential nutrients for promoting bone development. For adolescents in the rapid growth stage, daily dietary supplements cannot supply the needs of bone growth. In addition, the calcium-phosphorus ratio in celery seeds is reasonable, which can effectively supplement the deficiencies in adolescents' daily diets, promote healthy bone growth, and reduce the risk of dwarfism caused by malnutrition. At the same time, for the elderly, celery seeds can prevent bone nutrition deficiency caused by aging, maintain bone density, and reduce the incidence of osteoporosis.

[0006] In the specific implementation, the present invention uses a scientific experimental method to verify the effect of celery seeds on promoting bone growth. By comparing the data of the experimental group and the control group, the results also show that celery seeds significantly increase bone density and growth rate, confirming its positive role in bone development. In addition, the safety of celery seeds has also been verified, and long-term use has no obvious side effects, providing reliable bone health care effects for people of all ages.

[0007] In addition, the present invention verifies the effect of celery seeds on bone development in people of different age groups through examples. The results show that children, adolescents and the elderly all benefit significantly, which is mainly reflected in the obvious increase in height of children and adolescents and the steady improvement in bone density of the elderly. This further confirms the wide applicability and effectiveness of celery seeds in promoting bone health.

[0008] To achieve the above effects, the inventor team used a juvenile animal model for experiments. After a period of feeding, their growth was observed. The results showed that the growth rate and bone density of the juvenile animals in the experimental group were significantly higher than those in the control group, verifying the effectiveness of celery seeds. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 : Comparison of femur length between male and female mice in different groups; P<0.05 for the experimental group compared with the normal group.

[0011] Figure 2 :Effects of different groups on serum growth hormone levels in male and female mice; compared with the normal group, the experimental group was P<0.05.

[0012] Figure 3 :Effects of different groups on serum parathyroid hormone levels in male and female mice; compared with the normal group, the experimental group was P<0.05.

[0013] Figure 4 :Effects of different groups on serum 1,25(OH)2D3 levels in male and female mice; P<0.05 for the experimental group compared with the normal group.

[0014] Figure 5 :Effects of different groups on serum osteocalcin levels in male and female mice; compared with the normal group, the experimental group had P<0.05. DETAILED DESCRIPTION

[0016] The application of celery seeds in promoting bone development of the present invention is further described below by way of examples, but the present invention is not limited to the scope of the experimental examples. The experimental methods without specific conditions in the following experimental examples are selected according to conventional methods and conditions, or according to the product instructions.

[0017] Example 1 Establishment of mouse model

[0018] All animal experiments involved in this embodiment used pathogen-free mice as the experimental mouse model, and the mouse model was young mice bred by the company according to the experimental requirements.

[0019] The mice were 2-week-old mice that could forage normally and were divided into an experimental group and a control group, with half male and half female in each group. The mice in the experimental group were fed with ordinary feed containing celery seeds every day, while the mice in the control group were fed with ordinary feed.

[0020] The experimental group and the control group were further observed for 7 weeks, with body weight recorded and bone development changes observed every week.

[0021] Example 2: Effects of the experimental groups on femur length in male and female mice

[0022] Two-week-old pups were selected from the experimental and control groups, and the male and female mice were caged and fed separately. The experimental group had free access to water and was fed a fixed amount of ordinary feed containing celery seeds every day, while the control group had free access to water and was fed a fixed amount of ordinary feed.

[0023] The experiment started after the animals were adapted for one week and lasted for 7 weeks. The specific treatments were as follows:

[0024] Control group: free access to water and regular diet from 2 weeks after birth;

[0025] Experimental group: The rats were allowed to drink water freely from 2 weeks after birth and were fed with a fixed amount of ordinary feed mixed with 20% celery seed powder.

[0026] Feed until 7 weeks old. After the experiment, take whole blood from male and female mice, centrifuge and collect serum. Use vernier caliper to measure the length of femur. The results are as follows: Figure 1 .

[0027] Depend on Figure 1 It can be seen that the femur length of the female normal group was 11.61mm, and that of the female experimental group was 12.43mm; the femur length of the male normal group was 12.24mm, and that of the male experimental group was 12.83mm.

[0028] Example 3: Effect of celery seeds on serum growth hormone levels in male and female mice

[0029] The grouping and modeling of mice were the same as in Example 2. Serum of male and female young mice was taken and the serum growth hormone level of each group of mice was measured by ELISA kit. The results are shown in Figure 2 .

[0030] Growth hormone can promote growth, promote the division of bone, cartilage, muscle and other tissue cells and protein synthesis, thereby accelerating bone growth and development. The serum growth hormone levels of male and female mice in the experimental group after daily feeding were significantly higher than those in the normal group; the serum growth hormone concentration of the normal group of female mice was 13.62μg / L, and that of the experimental group of female mice was 15.68μg / L; the serum growth hormone concentration of the normal group of male mice was 15.45μg / L, and that of the experimental group of male mice was 17.57μg / L.

[0031] Example 4: Effect of celery seeds on serum parathyroid hormone levels in male and female mice

[0032] The grouping and treatment of mice were the same as in Example 2. After the experiment, blood was collected and the mice were killed. The level of parathyroid hormone in the serum of each group of mice was measured by ELISA kit. The test results are shown in Figure 3 .

[0033] Parathyroid hormone regulates the balance of blood calcium and bone calcium. A decrease in parathyroid hormone indicates a low blood calcium concentration, and the calcium used for bone tissue growth has not entered the blood. After daily feeding, the serum parathyroid hormone levels of male and female mice in the experimental group were significantly lower than those in the normal group; the serum parathyroid hormone concentration of the normal female group was 62.27ng / L, and that of the experimental female group was 51.29ng / L; the serum parathyroid hormone concentration of the normal male group was 65.54ng / L, and that of the experimental male group was 52.56ng / L.

[0034] Example 5: Effect of celery seeds on serum 1,25(OH)2D3 levels in male and female mice.

[0035] The grouping and modeling of mice were the same as in Example 2. After the experiment, blood was collected and the mice were killed. The 1,25(OH)2D3 level in the serum of each group of mice was measured by ELISA kit. The results are shown in Figure 4 .

[0036] 1,25(OH)2 D3 can directly act on bone mineral metabolism, promoting bone matrix formation and osteoid mineralization.

[0037] After daily feeding, the serum 1,25(OH)2 D3 levels of both male and female experimental mice were significantly higher than those of the normal group; the serum 1,25(OH)2D3 concentration of the female normal group was 33.73 ng / L, and that of the female experimental group was 41.25 ng / L; the serum 1,25(OH)2 D3 concentration of the male normal group was 39.29 ng / L, and that of the male experimental group was 48.42 ng / L.

[0038] Example 6: Effect of celery seeds on serum osteocalcin levels in male and female mice

[0039] The grouping and modeling of mice were the same as in Example 2. After the experiment, blood was collected and the mice were killed. The level of osteocalcin in the serum of each group of mice was measured by ELISA kit. The test results are shown in Figure 5 .

[0040] Osteocalcin is a sensitive marker of osteoblast function and plays an important role in the diagnosis and treatment of osteoporosis and calcium metabolism diseases. The serum osteocalcin levels of male and female mice in the experimental group were significantly higher than those in the normal group after daily feeding; the serum osteocalcin concentration of the normal female group was 25.28ng / L, and that of the experimental female group was 28.79ng / L; the serum osteocalcin concentration of the normal male group was 25.54ng / L, and that of the experimental male group was 32.68ng / L.

[0041] The above embodiments are sufficient to illustrate that celery seeds can promote bone development in adolescents and prevent the inconvenience caused by osteoporosis in the elderly.

[0042] Although the present invention is disclosed in terms of preferred embodiments, it is not intended to limit the present invention. Anyone with this technology can make various modifications and combinations without departing from the product and scope of the present invention. Therefore, the scope of protection of the present invention should be based on the definition of the claims.

Claims

1. Celery seeds are used to promote bone development. Celery seeds are mainly used to promote bone development in adolescents and osteoporosis in the elderly.

2. The celery seeds according to claim 1 can be celery seed powder, celery seed extract, apigenin and dried celery seeds.

3. The method of claim 1, wherein the celery seeds promote bone development, It can promote the calcium and phosphorus elements needed for bone development in adolescents at a high-speed development age, and cooperate with daily diet to promote the substances needed for bone development.

4. The method of claim 1, wherein the celery seeds promote bone development, It can prevent and supplement the bone nutrition deficiency caused by the decline of various body functions in the elderly due to aging.

5. according to claim 1, celery seeds can be in the form of tablets, powders, granules, soft capsules or oral preparations according to the needs of the population.

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