Biosafety medium and small animal infection transmission device

Abstract

The invention relates to a biosafety medium and small animal infection transmission device, and relates to the technical field of infection transmission experiment devices. The droplet infection cabin is arranged beside the infected animal cabin and communicated with the infected animal cabin, and the communication position is isolated through two layers of screens; the aerosol infection cabin is communicated with the droplet infection cabin through a pipeline; the drying and cooling device is communicated with the infected animal cabin; the communicating pipe is provided with a first filter, and the first filter is communicated with the aerosol infection cabin; the delivery window is arranged on the cabin body in a communicating manner and is used for inputting or outputting articles into or out of the cabin; the second fan is communicated with a second filter, and the second filter is communicated with the delivery window. And the animal limiting module is arranged in the cabin body and is used for limiting the activity range of animals. By arranging the cabin body suitable for small and medium-sized animal transmission infection experiments, the requirements of the small and medium-sized animal transmission infection experiments are met.

Description

Technical Field

[0001] The present application relates to the field of infection transmission experimental devices, and in particular to a biosafety infection transmission device for small and medium-sized animals. Background Art

[0002] At present, in order to make a rapid and accurate diagnosis of infectious diseases, it is often necessary to conduct a comprehensive inspection and analysis of pathogenic microorganisms. Inhalation toxicology is a science that studies the various conditions, laws and mechanisms of the occurrence, development and elimination of the toxic effects of inhalable substances on the body, as well as the risk assessment of inhalable substances.

[0003] As international inhalation toxicology research becomes increasingly active, many domestic experts have also fully realized the importance of inhalation toxicology. For example, in some existing inhalation toxicology studies, healthy animals and animals with pathogens are used for experiments, and healthy animals are infected through the exhaled droplets and aerosols of the pathogenic animals, and then experiments such as droplet and aerosol transmission of infection between animals are conducted.

[0004] Some animals, such as mice, are small in size and do not take up much space, so multiple mice can be placed in one experimental device at the same time. However, for some larger animals, such as monkeys, they take up a lot of space, and it is difficult for an experimental three-level cabinet or other device to accommodate two or more monkeys or monkey cages at the same time. Therefore, it is necessary to provide a transmission infection device for conducting transmission infection experiments on small and medium-sized animals. Summary of the invention

[0005] In view of the above problems, the present application is proposed to provide a biosafety device for transmitting infection to small and medium-sized animals that overcomes the above problems or at least partially solves the above problems.

[0006] The biosafety small and medium-sized animal infection transmission device provided in this application adopts the following technical solution: A biosafety type small and medium animal transmission infection device, an infected animal cabin, for placing infected animals; The droplet infection cabin is used to place healthy animals, and is arranged beside the infected animal cabin and connected thereto, and the connection is isolated by two layers of screens; an aerosol infection cabin, used to place healthy animals and connected to the droplet infection cabin via a pipeline; A drying and cooling device, which is in communication with the infected animal cabin and is used to deliver air with a certain temperature and humidity into the infected animal cabin; A first fan, a connecting pipe is provided with a first filter, and the first filter is connected to the aerosol infection cabin; A transfer window is connected to the infected animal cabin, the droplet infection cabin and the aerosol infection cabin, and is used to input or output items into or out of the cabin; The second fan is connected to a second filter, and the second filter is connected to the transfer window.

[0007] And an animal limiting module is arranged in the infected animal cabin, the droplet infection cabin and the aerosol infection cabin, and is used to limit the animal's activity range.

[0008] Optionally, the animal restraint module includes: The isolation frame is horizontally arranged in the cabin and can move vertically along the height direction of the cabin; The up and down lifting assembly comprises a lifting screw with a lifting nut and a lifting drive mechanism, wherein the lifting screw is vertically arranged in the isolation cabin below the cabin body and is rotatably connected thereto, and a lifting plate is arranged on the lifting nut, and the lifting plate is connected to the isolation frame through a support rod vertically penetrating the bottom of the cabin body; the lifting drive mechanism is used to drive the lifting screw to rotate; An extrusion frame is vertically arranged in the cabin and can slide horizontally along the length direction of the cabin; And left and right extrusion components, including an extrusion screw with an extrusion nut and an extrusion drive mechanism, the extrusion screw is horizontally arranged in the cabin and rotatably connected thereto, the extrusion nut is connected to the extrusion frame; the extrusion drive mechanism is used to drive the extrusion screw to rotate.

[0009] Optionally, the extrusion frame comprises: A frame connected to the extrusion nut; A pair of grille frames are provided, wherein the pair of grille frames are vertically arranged side by side in the frame, and the sides close to each other are rotatably connected to the frame through a rotating shaft; a pair of rotating shafts are provided with gears, and the pair of gears are meshed for transmission; and a locking mechanism, which is arranged between the frame and the grille frame and is used for adjusting and controlling the unfolding and folding of a pair of the grille frames.

[0010] Optionally, the locking mechanism includes: A locking base is sleeved on the outside of each of the rotating shafts, and a pair of the locking bases are connected to each other or to the frame; A locking ratchet, disposed on each of the rotating shafts and located inside the locking base; And a locking spring pin is arranged on each of the locking bases, and a locking ratchet tooth meshing with the locking ratchet wheel is arranged at the end, and the meshing directions of the two pairs of corresponding locking ratchets and the locking ratchets are the same.

[0011] Optionally, the locking base is movably arranged, a retractable driving rod is connected to the locking base, and a limiting fixture for limiting the driving rod is arranged on the frame.

[0012] Optionally, the limiting mechanism includes a pair of baffles, and the pair of baffles are respectively arranged at two sides of the frame.

[0013] Optionally, the limiting mechanism includes a pair of clamping rings, and the pair of clamping rings are respectively arranged on both sides of the frame.

[0014] Optionally, the isolation frame includes a first isolation frame and a second isolation frame, and the first isolation frame and the second isolation frame are respectively provided with an up and down lifting assembly.

[0015] Optionally, a plurality of the extrusion screws are provided, and the plurality of the extrusion screws are evenly arranged along the circumferential direction of the cabin body.

[0016] Optionally, the cabin is provided with a plurality of glove openings, and each of the glove openings is provided with an opening and closing plate for closing the opening, and the opening and closing plate includes: A plate body, corresponding to the shape of the opening of the glove opening, and one side of the plate body is hinged to the glove opening; the plate body is provided with a sliding groove along its radial direction; A sliding buckle is arranged in the sliding groove and can slide along the length direction thereof; a locking groove is arranged on the inner side wall of the glove opening, and when the plate body is in a state of blocking the opening of the glove opening, the sliding buckle can be inserted into the locking groove; A knob, disposed on the plate body and used to drive the sliding buckle to move toward the inner side of the sliding groove; and a return spring, which is arranged in the slide slot and is used to drive the sliding buckle to move and return along the outer side of the slide slot.

[0017] Optionally, the sliding buckle may be provided with a plurality (N≥2), the plate body is provided with the sliding grooves corresponding to the number of the sliding buckles evenly along its circumferential direction, the inner side wall of the glove opening is provided with the locking grooves corresponding to the number of the sliding buckles evenly along its circumferential direction, and the inner ends of the sliding buckles are rotatably connected with connecting rods; The knob is concentrically arranged with the plate body and is rotatably connected with the plate body; the ends of the plurality of connecting rods away from the sliding buckle are rotatably connected with the edge of the knob and are evenly arranged along the circumferential direction of the knob.

[0018] Optionally, a door is provided at the connection point between the transfer window and the cabin, and an opening and closing component for controlling the opening and closing of the door is also provided on the transfer window, and the opening and closing component includes: A shaft body, arranged parallel to the side wall of the transfer window and rotatably connected thereto; A rolling groove is located on the opening and closing door and is arranged along the length direction of the opening and closing door; An opening and closing rod, one end of which is fixedly connected to the shaft body, and the other end of which is inserted into the rolling groove and rotatably connected to a roller, and the roller can roll and slide along the length direction of the rolling groove; And an opening and closing driving mechanism is used to drive the shaft to rotate.

[0019] Optionally, the rolling grooves and the opening and closing rods may be provided in a plurality of pairs (N≥2) corresponding to each other, that is, the plurality of rolling grooves and the plurality of opening and closing rods may be provided in a one-to-one corresponding manner.

[0020] In summary, this application includes the following beneficial technical effects: 1. This application meets the needs of small and medium-sized animal transmission infection experiments by providing a cabin that is also suitable for small and medium-sized animal transmission infection experiments; 2. This application realizes the clamping and limiting of experimental animals by setting a limiting module that can limit the experimental animals in three directions in the cabin, which is convenient for experimental personnel to perform sampling or blood drawing operations and ensures the safety of experimental personnel. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application; Figure 2 is a schematic structural diagram of an animal limiting module in an embodiment of the present application; Figure 3 It is a schematic diagram of the structure of the transfer window in the embodiment of the present application; Figure 4 It is a structural schematic diagram of the opening and closing assembly in the embodiment of the present application; Figure 5 is a structural schematic diagram of a first embodiment of an extrusion frame in an embodiment of the present application; Figure 6 is a structural schematic diagram of a first embodiment of a locking mechanism in an embodiment of the present application; Figure 7 This is a schematic diagram of the structure of the second embodiment of the extrusion frame in the embodiment of the present application. Figure 1 ; Figure 8 This is a schematic diagram of the structure of the second embodiment of the locking mechanism in the embodiment of the present application. Figure 1 ; Fig. 9 This is a schematic diagram of the structure of the second embodiment of the extrusion frame in the embodiment of the present application. Figure 2 ; Fig.10 This is a schematic diagram of the structure of the second embodiment of the locking mechanism in the embodiment of the present application. Figure 2 ; Fig.11 Schematic diagram of the connection between the glove opening and the opening and closing plate in the embodiment of the present application; Fig.12 It is a structural schematic diagram of the opening and closing plate in the embodiment of the present application; Description of reference numerals: 1. infected animal cabin; 2. droplet infection cabin; 3. aerosol infection cabin; 4. transfer window; 41. opening and closing door; 42. opening and closing assembly; 421. shaft; 422. rolling groove; 423. opening and closing rod; 5. animal limiting module; 51. isolation frame; 52. up and down lifting assembly; 521. lifting screw; 522. lifting plate; 53. extrusion frame; 531. frame; 5311. baffle; 5312. snap ring; 53 2. Grid frame; 5321. Rotating shaft; 5322. Gear; 533. Locking mechanism; 5331. Locking base; 53311. Driving rod; 5332. Locking ratchet; 5333. Locking spring pin; 54. Left and right extrusion components; 541. Extrusion screw; 6. Glove opening; 61. Opening and closing plate; 611. Plate body; 6111. Slide groove; 612. Sliding buckle; 613. Knob; 614. Return spring; 615. Connecting rod. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiment is one embodiment of the present invention, not all embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.

[0024] This embodiment provides a biosafety device for the transmission of infection to small and medium-sized animals.

[0025] Reference Figure 1 A biosafety small and medium-sized animal transmission infection device includes an infected animal cabin 1, a droplet infection cabin 2, an aerosol infection cabin 3, a drying and cooling device, a first fan, a transfer window 4 and a second fan. The infected animal cabin 1 is used to place infected animals, that is, animals carrying pathogenic microorganisms; the droplet infection cabin 2 and the aerosol infection cabin 3 are used to place healthy animals. The droplet infection cabin 2 is arranged next to the infected animal cabin 1 and is connected with it, and the connection is isolated by two layers of screens, and the distance between the screens is preferably 10cm; the aerosol infection animal cabin 1 is connected to the droplet infection cabin 2 through a pipe, and the length of the pipe is preferably 1.5m.

[0026] The drying and cooling device is connected to the infected animal cabin 1, and is used to input air with a certain temperature and humidity into the infected animal cabin 1, so as to provide environmental conditions for simulating the transmission and infection conditions of pathogenic microorganisms under different temperature and humidity environments in the infected animal cabin 1, the droplet infection cabin 2 and the aerosol infection cabin 3; the first fan is connected to the aerosol infection cabin 3, and in order to prevent the aerosol in the cabin from leaking to the outside, a first filter is also provided between the first fan and the aerosol infection cabin 3; there are three transfer windows 4, which are respectively connected to the cabin bodies (in this application, the cabin body refers to the infected animal cabin 1, the droplet infection cabin 2 and the aerosol infection cabin 3) of the infected animal cabin 1, the droplet infection cabin 2 and the aerosol infection cabin 3, and the connection state between the transfer window 4 and the cabin body can be controlled so as to input or output items into or out of the cabin during the experiment; the second fan is connected to the transfer window 4 arranged on the cabin body, and in order to prevent the aerosol in the transfer window 4 from leaking to the outside, a second filter is also provided between the second fan and the transfer window 4.

[0027] Reference Figure 1-Figure 4 The connection between the transfer window 4 and the cabin is provided with an opening and closing door 41, and the opening and closing door 41 is hinged to the transfer window 4, and the opening and closing of the opening and closing door 41 is controlled by an opening and closing assembly 42 also provided on the transfer window 4. The opening and closing assembly 42 includes a shaft 421, a rolling groove 422, an opening and closing rod 423 and an opening and closing driving assembly.

[0028] The shaft 421 is arranged parallel to the side wall of the transfer window 4 and is rotatably connected to the transfer window 4. The opening and closing driving mechanism is used to drive the rotating shaft 5321 to rotate, and is preferably a hand wheel, a motor, etc. The rolling groove 422 is located in the middle of the inner side of the opening and closing door 41 and is arranged along its length direction. One end of the opening and closing rod 423 is fixedly connected to the shaft 421, and the other end is penetrated in the rolling groove 422 and rotatably connected to a roller, and the roller can roll and slide along the length direction of the rolling groove 422. Therefore, when the shaft 421 drives the opening and closing rod 423 to rotate, the roller rolls along the rolling groove 422, and the opening and closing door 41 is driven to rotate along the hinge point, so that the opening and closing control of the opening and closing door 41 can be realized.

[0029] In the specific implementation process, in order to ensure the support stability of the opening and closing door 41 in the opening and closing state, multiple pairs of rolling grooves 422 and opening and closing rods 423 can be correspondingly arranged, and multiple rolling grooves 422 are evenly spaced along the inner width direction of the opening and closing door 41, and multiple opening and closing rods 423 are evenly spaced along the direction of the shaft body 421, and multiple rolling grooves 422 and multiple opening and closing rods 423 are arranged one by one. In this application, the preferred implementation scheme is: a pair of opening and closing rods 423 and rolling grooves 422 are each arranged, a pair of opening and closing rods 423 are distributed at both sides of the shaft body 421, and a pair of rolling grooves 422 are correspondingly distributed at both sides of the inner side of the opening and closing door 41.

[0030] In order to further ensure the tightness of the connection between the opening and closing door 41 and the transfer window 4 in the closed state, an electromagnetic adsorption component can be arranged between the opening and closing door 41 and the transfer window 4 to prevent the gas in the cabin from entering the transfer window 4 when the transfer window 4 is not in working state and causing pollution to the transfer window 4.

[0031] Reference Figure 1 , Figure 2 In order to facilitate blood collection and sampling operations on animals in the cabin, an animal limiting module 5 for limiting the animal's limbs is provided in the cabin, and a glove opening 6 is provided on the cabin to facilitate the experimenter's hands to penetrate into the cabin.

[0032] The animal limiting module 5 includes an isolation frame 51 , an up and down lifting assembly 52 , an extrusion frame 53 and left and right extrusion assemblies 54 .

[0033] The isolation frame 51 is horizontally arranged in the cabin body, and the up and down lifting assembly 52 is used to drive the isolation frame 51 to slide along the height direction of the cabin body to realize the height direction restriction of the animal movement space. It includes a lifting screw 521 with a lifting nut and a lifting drive mechanism. An isolation cabin is arranged under the cabin body. The lifting screw 521 is vertically arranged in the isolation cabin and is rotatably connected thereto. The lifting drive mechanism is used to drive the lifting screw 521 to rotate.

[0034] The up and down lifting assembly 52 also includes a lifting plate 522, which is horizontally arranged in the isolation cabin and connected to the lifting nut, and the lifting plate 522 is connected to the isolation frame 51 through a support rod vertically running through the bottom of the cabin, so as to drive the lifting plate 522 to do vertical lifting movement during the movement of the lifting nut along the lifting screw, and then drive the isolation frame 51 to do vertical lifting movement through the support rod, so as to achieve the limit control of the height direction of the animal. In the specific implementation process, a plurality of support rods can be provided, and the plurality of support rods are evenly arranged along the edge position of the lifting plate 522 to ensure the connection stability of the lifting plate 522 and the isolation frame 51. At the same time, in order to ensure the connection stability of the lifting nut and the lifting plate 522, a light rod can also be provided on the top of the isolation cabin, and the lifting plate 522 is vertically slidably connected to the light rod.

[0035] In actual use, in order to cooperate with the transfer window 4 to input or output items into the cabin, the isolation frame 51 may include a first isolation frame and a second isolation frame arranged side by side, and the first isolation frame and the second isolation frame are correspondingly provided with an upper and lower lifting assembly 52.

[0036] Reference Figure 1 , Figure 2 as well as Figure 5-Figure 10The extrusion frame 53 is vertically arranged in the cabin and located above the isolation frame 51. The left and right extrusion components 54 are used to drive the extrusion frame 53 to slide along the length direction of the cabin to achieve the left and right direction limit of the animal's movement space. The left and right extrusion components 54 include an extrusion screw 541 with an extrusion nut and an extrusion driving mechanism. The extrusion screw 541 is horizontally arranged in the cabin and rotatably connected thereto. The extrusion nut is connected to the extrusion frame 53. The extrusion driving mechanism is used to drive the extrusion screw 541 to rotate, so as to drive the extrusion frame 53 to slide along the length of the cabin during the movement of the extrusion nut along the extrusion screw 541, so as to achieve the left and right direction limit control of the animal.

[0037] During the specific implementation, multiple extrusion screws 541 may be provided, and the multiple extrusion screws 541 are evenly distributed along the circumferential direction of the extrusion frame 53 to ensure the stability of the sliding movement of the extrusion frame 53; in this application, the optimal implementation scheme is: four extrusion screws 541 are provided, and the four extrusion screws 541 are distributed at the four corners of the cabin, which can ensure the rationality of the internal space utilization of the cabin while ensuring the sliding stability of the extrusion frame 53.

[0038] In order to further limit the animal's movement space, the squeezing frame 53 is configured to be foldable to limit the animal's movement space in three directions, thereby minimizing the animal's movement space as much as possible and facilitating operations such as blood drawing or sampling on the animal.

[0039] The extrusion frame 53 includes a frame 531 and a grid frame 532. A pair of grid frames 532 are arranged side by side in the frame 531, and the sides of the pair of grid frames 532 close to each other are rotatably connected to the frame 531 through a rotating shaft 5321, and the pair of rotating shafts 5321 are provided with gears 5322, and the pair of gears 5322 are meshed for transmission.

[0040] In order to facilitate the control of the mutual folding angle of the pair of grid frames 532 , the extrusion frame 53 further includes a locking mechanism 533 , which includes a pair of locking bases 5331 , a pair of locking ratchets 5332 and a pair of locking spring pins 5333 .

[0041] In the first embodiment, a pair of locking bases 5331 are respectively sleeved on the outer sides of a pair of rotating shafts 5321 and are connected to each other or fixedly connected to the frame 531, a pair of locking ratchets 5332 are respectively sleeved on the pair of rotating shafts 5321 and are located on the inner sides of the locking bases 5331, a pair of locking spring pins 5333 are respectively arranged on the pair of locking bases 5331, and the ends of the locking spring pins 5333 are respectively provided with locking ratchets that mesh with the corresponding locking ratchets 5332 for transmission, and the locking directions of the two pairs of correspondingly arranged locking ratchets 5332 and the locking ratchets are the same.

[0042] In the above embodiment, when the pair of locking ratchets are respectively engaged with the pair of locking ratchets 5332, the pair of grid frames 532 are locked with each other, and the pair of grid frames 532 cannot rotate. When the locking ratchets are driven by the locking spring pins 5333 and are disengaged from the corresponding locking ratchets 5332, the grid frames 532 can be unfolded or folded.

[0043] In order to facilitate understanding of the locking situation of the locking mechanism 533, the present application is as follows: Figure 5 , Figure 6 As a specific embodiment, in this embodiment, the locking ratchet 5332 and the locking ratchet teeth are engaged in a transmission direction that is counterclockwise, that is, when the corresponding locking ratchet 5332 and the locking ratchet teeth are in an engaged state, the locking ratchet 5332 can rotate counterclockwise.

[0044] when Figure 6 When the locking ratchets on the left and right sides are in meshing state with the corresponding locking ratchet wheels 5332, since the locking ratchet wheels 5332 can only rotate counterclockwise at this time, and the rotation directions of a pair of grille frames 532 are opposite when the grille frames 532 are folded or unfolded, they are in a mutually locked state, and the grille frames 532 on both sides cannot move.

[0045] when Figure 6 When the locking ratchet located on the right side is driven by the locking spring pin 5333 to disengage from the corresponding locking ratchet 5332, the locking ratchet 5332 located on the left side can rotate counterclockwise, and the pair of grill frames 532 can be driven to move away from each other, so that the grill frames 532 can be unfolded; when Figure 6 When the locking ratchet on the left is disengaged from the corresponding locking ratchet 5332 under the drive of the locking spring pin 5333, the locking ratchet on the right can rotate counterclockwise, and at this time, a pair of grill frames 532 can be driven to move toward each other, thereby realizing the folding of the grill frames 532.

[0046] In the second embodiment, the difference from the first embodiment is that the locking base 5331 is movably arranged, that is, the locking base 5331 is neither connected to each other nor to the frame 531, but a retractable driving rod 53311 is connected to the locking base 5331, and a limiting fixture for limiting the driving rod 53311 is provided on the frame 531. The limiting fixture is preferably set as a pair of baffles 5311 or a pair of retaining rings 5312.

[0047] When the limiting fixture is a pair of baffles 5311 respectively arranged at the two sides of the frame 531. In order to facilitate understanding of the locking situation of the above-mentioned locking mechanism 533, this application uses Figure 7 , Figure 8As a specific embodiment, in this embodiment, the locking ratchet 5332 and the locking ratchet teeth are engaged in a transmission direction that is counterclockwise, that is, when the corresponding locking ratchet 5332 and the locking ratchet teeth are in an engaged state, the locking ratchet 5332 can rotate counterclockwise.

[0048] In the initial state, the pair of driving rods 53311 respectively abut against the outer sides of the pair of baffles 5311, and at this time, the baffles 5311 restrict the outward folding of the grille frame 532, and the driving rods 53311 restrict the inward folding of the grille frame 532, and at this time, the grille frame 532 is in a fully expanded state; When folding the grille frame 532, first retract the right driving rod 53311 and drive it to rotate a certain angle in the clockwise direction, then pull out the left locking spring pin 5333, and then control the right driving rod 53311 to rotate counterclockwise, and then drive the right grille frame 532 to rotate counterclockwise through the cooperation of the locking ratchet and the locking ratchet 5332, and at the same time, the right grille frame 532 drives the left grille frame 532 to move clockwise through the gear 5322, so that the grille frame 532 can be folded; when the grille frame 532 is folded to a suitable angle, then the right driving rod 53311 is abutted against the inner side of the baffle 5311 and the left locking spring pin 5333 is inserted, and finally the left driving rod 53311 is abutted against the inner side of the baffle 5311, at this time, a pair of grille frames 532 are limited to each other, and the grille frame 532 is fixed.

[0049] When unfolding the grille frame 532, the left drive rod 53311 is retracted and driven to rotate clockwise, and then the locking spring pin 5333 on the right is pulled out, and then the left drive rod 53311 is controlled to rotate counterclockwise, and then the left grille frame 532 is driven to rotate counterclockwise through the cooperation of the locking ratchet and the locking ratchet 5332, so that the grille frame 532 can be unfolded; when unfolded to a suitable state, the right locking spring pin 5333 is then inserted and the left drive rod 53311 is abutted against the inner side (or outer side) of the baffle 5311, and then the right drive rod 53311 is abutted against the inner side (or outer side) of the baffle 5311, so that the grille frame 532 can be unfolded (or fully unfolded).

[0050] When the limiting fixture is a pair of clamping rings 5312 respectively arranged on both sides of the frame 531, the driving rod 53311 is located outside the grid frame 532 and can be extended and controlled to pass through the clamping ring 5312. Fig. 9 , Fig.10In the case shown in , when folding the grille frame 532, it is only necessary to pull out the locking spring pin 5333 on the left side, and then drive the right grille frame 532 to rotate in the opposite direction through the driving rod 53311 on the right side, and then drive the left grille frame 532 to rotate clockwise through the gear 5322, so that the grille frame 532 can be folded; when unfolding the grille frame 532, it is only necessary to pull out the locking spring pin 5333 on the right side, and then drive the left grille frame 532 to rotate counterclockwise through the driving rod 53311 on the left side, and then drive the right grille frame 532 to rotate clockwise through the gear 5322, so that the grille frame 532 can be unfolded.

[0051] Reference Figure 1 , Fig.11 as well as Fig.12 In order to prevent the experimental animals in the cabin from scratching the gloves at the glove opening 6 during the experiment, an opening and closing plate 61 for closing the opening is provided in the glove opening 6. The opening and closing plate 61 includes a plate body 611, a sliding buckle 612, a knob 613 and a return spring 614.

[0052] The plate body 611 is arranged in the glove opening 6, corresponding to the opening shape of the glove opening 6 and used to block the opening, and one side of the plate body 611 is hinged to the glove opening 6. A slide groove 6111 is arranged on the plate body 611 along its radial direction, and the sliding buckle 612 is located in the slide groove 6111 and can slide along its length direction, wherein the knob 613 is arranged on the plate body 611 and used to drive the sliding buckle 612 to slide toward the inside of the slide groove 6111, and the reset spring 614 is arranged in the slide groove 6111 and used to drive the sliding buckle 612 to slide and reset along the outside of the slide groove 6111, and when the plate body 611 is in a state of blocking the opening of the glove opening 6, the sliding buckle 612 can be inserted into the locking groove arranged on the inner wall of the glove opening 6.

[0053] In the specific implementation process, in order to ensure the stability of the connection between the plate body 611 and the glove opening 6, a plurality of sliding buckles 612 (N≥2) can be provided, and a plurality of sliding grooves 6111, locking grooves and return springs 614 can be provided accordingly.

[0054] Multiple slide grooves 6111 are evenly arranged along the circumferential direction of the plate body 611, and multiple lock grooves are evenly arranged along the circumferential direction of the inner wall of the glove opening 6 and are arranged one by one with multiple slide grooves 6111. The knob 613 is arranged concentrically with the plate body 611 and is rotatably connected to the plate body 611; the inner ends of the sliding buckles 612 are all rotatably connected with connecting rods 615, and the ends of the multiple connecting rods 615 that are away from the sliding buckles 612 are all rotatably connected to the edge of the knob 613 and are evenly arranged along the circumferential direction of the knob 613. At this time, the knob 613 can synchronously drive the multiple sliding buckles 612 to slide synchronously along the slide grooves 6111 through the multiple connecting rods 615. In the present application, the preferred embodiment is: a pair of sliding buckles 612 are provided, and the pair of sliding buckles 612 are symmetrically distributed.

[0055] In the transmission and infection experiments of medium-sized animals, a medium-sized animal is placed in each of the infection animal cabin 1, droplet infection cabin 2 and aerosol infection cabin 3; in the small animal laboratory, the special cages for small animal transmission experiments can be directly placed in the cabin. At this time, the cabin can be regarded as a third-level cabinet, which can further ensure the safety of the transmission and infection experiment.

[0056] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A biosafety device for the transmission of infection from small and medium-sized animals, characterized in that: include, An infected animal cabin (1), used for placing infected animals; The droplet infection cabin (2) is used to place healthy animals and is arranged beside the infected animal cabin (1) and is connected thereto, and the connection point is isolated by two layers of screens; an aerosol infection chamber (3), used for placing healthy animals, and connected to the droplet infection chamber (2) via a pipeline; A drying and cooling device, which is in communication with the infected animal cabin (1) and is used to transport air with a certain temperature and humidity into the infected animal cabin (1); A first fan, the connecting pipe is provided with a first filter, and the first filter is connected to the aerosol infection cabin (3); A transfer window (4), which is connected to the infected animal cabin (1), the droplet infection cabin (2) and the aerosol infection cabin (3) and is used to input or output items into or out of the cabin; A second fan is connected to a second filter, and the second filter is connected to the transfer window (4); And an animal limiting module (5) is arranged in the infected animal cabin (1), the droplet infection cabin (2) and the aerosol infection cabin (3) and is used to limit the animal's activity range.

2. A biosafety small and medium-sized animal transmission infection device according to claim 1, characterized in that: The animal restraining module (5) comprises: The isolation frame (51) is horizontally arranged in the cabin and can move vertically along the height direction of the cabin; The up-and-down lifting assembly (52) comprises a lifting screw (521) with a lifting nut and a lifting drive mechanism, wherein the lifting screw (521) is vertically arranged in the isolation cabin below the cabin body and is rotatably connected thereto, and a lifting plate (522) is arranged on the lifting nut, and the lifting plate (522) is connected to the isolation frame (51) via a support rod vertically penetrating the bottom of the cabin body; the lifting drive mechanism is used for driving the lifting screw (521) to rotate; An extrusion frame (53) is vertically arranged in the cabin and can slide horizontally along the length direction of the cabin; and left and right extrusion assemblies (54), comprising an extrusion lead screw (541) with an extrusion nut and an extrusion drive mechanism, wherein the extrusion lead screw (541) is horizontally arranged in the cabin and rotatably connected thereto, and the extrusion nut is connected to the extrusion frame (53); and the extrusion drive mechanism is used for driving the extrusion lead screw (541) to rotate.

3. A biosafety small and medium-sized animal transmission infection device according to claim 2, characterized in that: The extrusion frame (53) comprises: A frame (531) connected to the extrusion nut; A pair of grille frames (532) are provided, wherein the pair of grille frames (532) are vertically arranged side by side in the frame (531), and the sides close to each other are rotatably connected to the frame (531) via a rotating shaft (5321); a pair of rotating shafts (5321) are provided with gears (5322), and the pair of gears (5322) are meshed for transmission; and a locking mechanism (533) disposed between the frame (531) and the grille frame (532) and used for adjusting and controlling the unfolding and folding of a pair of the grille frames (532).

4. A biosafety small and medium-sized animal transmission infection device according to claim 3, characterized in that: The locking mechanism (533) comprises: A locking base (5331) is sleeved on the outside of each of the rotating shafts (5321), and a pair of the locking bases (5331) are connected to each other or are both connected to the frame (531); A locking ratchet (5332), which is arranged on each of the rotating shafts (5321) and is located inside the locking base (5331); And a locking spring pin (5333) is arranged on each of the locking bases (5331), and a locking ratchet tooth meshing with the locking ratchet wheel (5332) is arranged at the end, and the meshing direction of the two pairs of corresponding locking ratchets (5332) and the locking ratchets is the same.

5. A biosafety small and medium-sized animal transmission infection device according to claim 4, characterized in that: The locking base (5331) is movably arranged, a retractable driving rod (53311) is connected to the locking base (5331), and a limiting fixture for limiting the driving rod (53311) is arranged on the frame (531).

6. A biosafety small and medium-sized animal transmission infection device according to claim 5, characterized in that: The limiting mechanism comprises a pair of baffles (5311), and the pair of baffles (5311) are respectively arranged at two sides of the frame (531).

7. A biosafety small and medium-sized animal transmission infection device according to claim 5, characterized in that: The limiting mechanism comprises a pair of snap rings (5312), and the pair of snap rings (5312) are respectively arranged at two sides of the frame (531).

8. A biosafety small and medium-sized animal transmission infection device according to claim 2, characterized in that: The isolation frame (51) comprises a first isolation frame and a second isolation frame, and the first isolation frame and the second isolation frame are both correspondingly provided with an up and down lifting assembly (52).

9. A biosafety small and medium-sized animal transmission infection device according to claim 2, characterized in that: A plurality of the extrusion screws (541) are provided, and the plurality of the extrusion screws (541) are evenly arranged along the circumferential direction of the cabin body.

10. A biosafety small and medium-sized animal transmission infection device according to claim 1, characterized in that: The cabin body is provided with a plurality of glove openings (6), and each of the glove openings (6) is provided with an opening and closing plate (61) for closing the opening, wherein the opening and closing plate (61) comprises: The plate body (611) corresponds to the opening shape of the glove opening (6), and one side of the plate body (611) is hinged to the glove opening (6); the plate body (611) is provided with a sliding groove (6111) along its radial direction; A sliding buckle (612) is arranged in the sliding groove (6111) and can slide along the length direction thereof; a locking groove is arranged on the inner side wall of the glove opening (6), and when the plate body (611) is in a state of blocking the opening of the glove opening (6), the sliding buckle (612) can be inserted into the locking groove; A knob (613) is disposed on the plate (611) and is used to drive the sliding buckle (612) to move toward the inner side of the sliding groove (6111); And a reset spring (614) is arranged in the slide groove (6111) and is used to drive the sliding buckle (612) to move along the outer side of the slide groove (6111) to reset.

11. A biosafety small and medium-sized animal transmission infection device according to claim 10, characterized in that: The sliding buckle (612) may be provided in plurality (N≥2), the plate body (611) is evenly provided with the sliding grooves (6111) corresponding to the number of the sliding buckles (612) along its circumferential direction, the inner side wall of the glove opening (6) is evenly provided with the locking grooves corresponding to the number of the sliding buckles (612) along its circumferential direction, and the inner ends of the sliding buckles (612) are rotatably connected with connecting rods (615); The knob (613) is arranged concentrically with the plate body (611) and is rotatably connected to the plate body (611); the ends of the plurality of connecting rods (615) away from the sliding buckle (612) are all rotatably connected to the edge of the knob (613) and are evenly arranged along the circumferential direction of the knob (613).

12. A biosafety small and medium-sized animal transmission infection device according to claim 1, characterized in that: The transfer window (4) and the cabin are both provided with an opening and closing door (41) at the connection point, and the transfer window (4) is also provided with an opening and closing component (42) for controlling the opening and closing of the opening and closing door (41), and the opening and closing component (42) comprises: A shaft (421) is arranged parallel to the side wall of the transfer window (4) and is rotatably connected thereto; A rolling groove (422) is located on the opening and closing door (41) and is arranged along the length direction of the opening and closing door (41); An opening and closing rod (423) has one end fixedly connected to the shaft body (421), and the other end is inserted into the rolling groove (422) and rotatably connected to a roller, and the roller can roll and slide along the length direction of the rolling groove (422); and an opening and closing driving mechanism, which is used to drive the shaft (421) to rotate.

13. A biosafety small and medium-sized animal transmission infection device according to claim 12, characterized in that: The rolling groove (422) and the opening and closing rod (423) may be arranged in a plurality of pairs (N≥2) corresponding to each other, that is, the plurality of rolling grooves (422) and the plurality of opening and closing rods (423) are arranged in a one-to-one correspondence.

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