Oral care composition for resisting dentin hypersensitivity and preparation method thereof

Abstract

The invention discloses an oral care composition for resisting dentin hypersensitivity and a preparation method thereof, the oral care composition comprises an anti-allergy agent, and the anti-allergy agent comprises sylvite, fluoride, a hydroxyapatite growth promoter and anti-allergy silicon dioxide. According to the oral care composition and the preparation method thereof, the multiple and efficient oral care composition capable of resisting dentin hypersensitivity and the preparation method of the oral care composition can be provided.

Description

Technical Field

[0001] The present application relates to the technical field of daily chemical product production, and in particular to an oral care composition for resisting dentin sensitivity and a preparation method thereof. Background Art

[0002] Oral health is an important part of overall health and directly affects a person's physical health and quality of life. Dentin sensitivity refers to the short and sharp pain caused by external stimuli in exposed dentin. Typical stimuli include temperature stimulation, air blowing stimulation, mechanical stimulation, osmotic pressure stimulation and chemical stimulation. Dentin sensitivity is mainly caused by dentin exposure caused by wear, abrasion, acid erosion, gingival recession and the use of bleaching agents. Dentin sensitivity can be effectively prevented by removing or reducing the above risk factors. For established dentin sensitivity, oral care products (toothpaste, mouthwash, etc.) can be used to improve mild discomfort, pain and other dentin sensitivity. The anti-sensitivity principles of oral care products include: blocking dentinal tubules, inhibiting the flow of fluid in dentinal tubules, and preventing pain transmission to the central nervous system by reducing the activity of dentinal sensory nerve fibers.

[0003] Current anti-allergic oral care products are mainly based on single or double anti-allergic ingredients. Different users have different demands for anti-allergic products. For example, some users hope to quickly relieve the hot, cold, sore and soft symptoms of their teeth, some users hope to continuously relieve dentin sensitivity, some hope to relieve sensitivity caused by mechanical stimulation (such as biting hard objects), and some hope to relieve sensitivity caused by temperature stimulation.

[0004] Therefore, a multiple, highly effective anti-sensitive oral care product is needed to help meet the needs of users. Summary of the invention

[0005] In order to overcome the deficiencies of the prior art and solve the problem that the anti-sensitivity oral care products in the prior art have a single anti-sensitivity effect and poor effect, the present application provides a multiple and highly effective anti-dentin sensitivity oral care composition and a preparation method thereof.

[0006] This application adopts the following technical solutions:

[0007] On one hand, the present application discloses an oral care composition for resisting dentin sensitivity, comprising an anti-sensitivity agent, wherein the anti-sensitivity agent comprises potassium salt, fluoride, hydroxyapatite growth agent, and anti-sensitivity silica, wherein the hydroxyapatite growth agent comprises at least one of calcium silicate and phosphate.

[0008] It should be noted that the oral care composition of the present application contains potassium salt, fluoride, hydroxyapatite growth agent, anti-sensitivity silica and other anti-dentin sensitivity mechanisms. The various anti-dentin sensitivity components work together to improve the problem of dentin sensitivity and have multiple anti-sensitivity effects. Among them, the potassium salt anti-sensitivity mechanism is mainly to reduce the sensitivity of dental nerves. Specifically, by increasing the potassium ion concentration around the dental pulp sensory nerve receptors, it can produce a depolarization phenomenon and reduce the excitability of the dental pulp nerve fiber endings. At the same time, potassium salt crystals can block the dentinal tubules, thereby isolating external stimuli. Potassium salt can instantly relieve the discomfort caused by dentin sensitivity and has a significant improvement in the sensitivity of dentin to air blowing and mechanical stimulation. The fluoride anti-sensitivity mechanism is mainly to form insoluble substances or guide mineralization to block the dentinal tubules. Specifically, fluoride It has a good anti-caries effect and is easily absorbed by the hard tissue of the tooth. Fluoride ions can penetrate and adsorb to the inner wall of the dentinal tubules and combine with the calcium salts therein, thereby growing or forming insoluble calcium chloride, fluoroapatite and other compounds in the dentinal tubules, shrinking or sealing the dentinal tubules. Fluoride usually has a significant improvement effect on the symptoms of dentin sensitivity caused by temperature stimulation; hydroxyapatite growth agents seal the dentinal tubules by promoting the nucleation and growth of hydroxyapatite on the tooth surface. Hydroxyapatite growth agents have a good effect on reducing the sensitivity of dentin to mechanical stimulation; the mechanism of anti-allergic silica is mainly direct physical sealing of dentinal tubules. The shape and particle size (small particle size) of anti-allergic silica are conducive to the sealing effect on the dentinal tubules, which can effectively block the fine channels on the tooth surface and block external stimulation.

[0009] In one implementation of the present application, the hydroxyapatite growth agent includes at least one of calcium silicate and phosphate. It should be noted that the calcium ions in the calcium silicate are exchanged with the hydrogen ions in the surrounding liquid, resulting in the generation of silicon-hydroxyl groups on its surface, which increases the pH of the surrounding environment and ultimately causes the surface of the calcium silicate to be rich in silicon oxygen anion functional groups and negatively charged. The silicon oxygen anion functional groups act as templates at the local pH, which is conducive to the nucleation and growth of hydroxyapatite. As calcium ions are released in water, the pH value of calcium silicate gradually increases. When calcium ions combine with phosphate ions in the surrounding liquid or saliva, hydroxyapatite is deposited on the surface of the calcium silicate. Calcium silicate / phosphate has a good effect in reducing the sensitivity of dentin to mechanical stimulation. In addition, various anti-allergic ingredients such as potassium salts, fluoride, hydroxyapatite growth agents, and anti-allergic silica work synergistically to further improve the problem of dentin sensitivity. For example, fluoride and phosphate work synergistically to significantly improve the remineralization efficiency of the tooth surface, and calcium silicate further promotes the formation of hydroxyapatite; phosphates and calcium silicate help maintain a stable pH value in the oral environment and reduce the erosion of teeth by acidic substances.

[0010] In one implementation of the present application, the oral care composition is an anhydrous oral care composition. It should be noted that an oral care composition refers to a formula that contains no or almost no water. Since fluoride and calcium silicate in the anti-allergic agent are prone to form calcium fluoride insolubles, which affect the subsequent release of fluoride ions, silicate and calcium ions, etc., resulting in the inactivation of effective ingredients and instability of the product, the oral care composition of the present application can be an anhydrous formula.

[0011] In one implementation of the present application, the potassium salt includes but is not limited to potassium nitrate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, and potassium fluoride, and the fluoride includes but is not limited to sodium fluoride, sodium monofluorophosphate, stannous fluoride, and potassium fluoride.

[0012] In one implementation of the present application, the anti-allergic silica is spherical and / or quasi-spherical. It should be noted that, compared with irregularly shaped silica, spherical and / or quasi-spherical anti-allergic silica can better and more effectively block dentinal tubules.

[0013] In one implementation of the present application, the particle size of the anti-allergic silica is less than 6 μm; preferably, the particle size D50 of the anti-allergic silica is 2 μm to 5 μm. It should be noted that the anti-allergic silica within this particle size range directly matches the dental tubules on the surface of sensitive dentin, and can effectively and directly physically block the dentin tubules. It should also be noted that the particle size or diameter in the present application may refer to an equivalent diameter.

[0014] In one implementation of the present application, the oral care composition further comprises at least one of the following: an abrasive, a thickener, a humectant, a solubilizer, a foaming agent, a sweetener, a fragrance, a preservative, and a pigment.

[0015] In one implementation of the present application, the abrasive includes at least one of calcium pyrophosphate and abrasive silica. It should be noted that calcium silicate in the anti-sensitivity agent can also be used as an abrasive, so no other abrasives may be added to the oral care composition of the present application. The abrasives are calcium silicate, calcium pyrophosphate, abrasive silica, etc., which have relatively mild friction performance and low heat sensation, reducing the heat sensation or discomfort of the user during use, which is conducive to improving the user experience of users with dentin sensitivity and reducing discomfort.

[0016] In one implementation of the present application, the particle size of the ground silicon dioxide is 5 μm to 20 μm. Preferably, the particle size D50 of the ground silicon dioxide is 10 μm to 15 μm.

[0017] In one implementation of the present application, the thickener includes at least one of carboxymethyl cellulose, xanthan gum, and microcrystalline cellulose.

[0018] In one implementation of the present application, the humectant includes at least one of glycerin, propylene glycol, sorbitol, polyethylene glycol, and erythritol.

[0019] In one implementation of the present application, the oral care composition includes at least one of the following, measured by weight: 1 to 50 parts of the antisensitizer, 0 to 20 parts of the abrasive, 0.5 to 2 parts of the thickener, 30 to 65 parts of the moisturizer, 1 to 5 parts of the foaming agent, 0 to 5 parts of the solubilizer, 0.05 to 8 parts of the sweetener, 0.1 to 5 parts of the fragrance, 0 to 5 parts of the preservative, and 0 to 1 part of the pigment.

[0020] In one implementation of the present application, the oral care composition includes, by weight: 0.01 to 10 parts of the potassium salt, 0.1 to 2 parts of the fluoride, 0.01 to 30 parts of the calcium silicate, 0.01 to 5 parts of the phosphate, and 0.1 to 10 parts of the anti-allergic silica.

[0021] In one implementation of the present application, the oral care composition includes, by weight: 0.5 to 5 parts of the potassium salt, 0.5 to 1.5 parts of the fluoride, 15 to 30 parts of the calcium silicate, 1 to 5 parts of the phosphate, 1 to 5 parts of the abrasive, 1 to 1.5 parts of the thickener, 40 to 60 parts of the humectant, 1.5 to 3 parts of the foaming agent, 0 to 1 part of the solubilizer, 0.1 to 0.5 parts of the sweetener, 0.5 to 1.5 parts of the fragrance, 0 to 1.5 parts of the preservative, and 0.01 to 0.3 parts of the pigment.

[0022] On the other hand, the present application discloses a method for preparing an oral care composition, comprising: preparing glue: heating and stirring a thickener and a moisturizer to obtain glue; preparing a paste: adding an anti-allergic agent, heating and stirring, adding other components, stirring at room temperature, and degassing to obtain a paste, namely the oral care composition.

[0023] The beneficial effects of this application are:

[0024] The oral care composition for resisting dentin hypersensitivity of the present application contains a variety of anti-dentin hypersensitivity ingredients, has multiple anti-sensitivity effects, and the ingredients work together and synergistically to improve the problem of dentin hypersensitivity, thereby providing a multiple and highly effective oral care composition for resisting dentin hypersensitivity. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a scanning electron micrograph of the surface of a tooth sample before treatment with the anti-allergic silica dispersion.

[0026] Figure 2 This is a scanning electron micrograph of the surface of a tooth sample treated with an anti-allergic silica dispersion. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. In the following embodiments, many detailed descriptions are intended to enable the present application to be better understood. However, those skilled in the art can effortlessly recognize that some of the features can be omitted in different situations, or can be replaced by other materials and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0028] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0029] Currently, the anti-sensitive toothpastes on the market are mainly based on single or double anti-sensitive ingredients, and their anti-sensitivity mechanisms are different. For example, potassium salts quickly relieve tooth sensitive nerves, strontium salts, fluorides or bioactive glass as the main anti-dentin sensitivity ingredients mineralize and continuously block open dentinal tubules, and anti-sensitive ingredients are added through the hydrated silica formula framework to achieve product development. However, when consumers have tooth sensitivity, their demand for toothpaste products is higher, and their expectations are also greater. It is also difficult to choose the right anti-sensitive toothpaste for their own symptoms. Some consumers hope that the product can quickly relieve the cold, hot, sour and soft phenomena of teeth, while other consumers hope that the anti-sensitivity effect of the product will last, and there will be relief when brushing, and the sensitivity will not recur after stopping brushing. These urgent needs.

[0030] In view of this, the present application creatively proposes an oral care composition with quadruple anti-dentin sensitivity effect and its preparation method, so as to enhance the anti-dentin sensitivity effect, solve the existing consumers' hope that anti-sensitive toothpaste can take effect quickly, sensitivity will not recur, and the anti-sensitivity effect will last for a long time, and there is a need for anti-sensitivity for the four sensitive sources of "cold, hot, sour and soft". The oral care composition contains an anti-sensitizer, which includes potassium salt, fluoride, hydroxyapatite growth agent, and anti-sensitivity silica. The anti-sensitivity principle of each component is as follows: (1) Reduce the sensitivity of dental nerve material - potassium salt, potassium ions can reduce the excitability of the pulp nerve fiber endings, and at the same time can block the dentinal tubules to reduce pain; its desensitization mechanism is to increase the potassium ion concentration around the pulp sensory nerve receptors, produce depolarization phenomenon and reduce nerve excitability, produce insoluble substances to block the dentinal tubules, and relieve the symptoms of dentin sensitivity. At the same time, studies have also shown that potassium salt crystals can block the dentinal tubules, thereby isolating external stimuli. Toothpaste containing potassium nitrate has a significant effect in immediately relieving tooth sensitivity and reducing the sensitivity of dentin to air blowing and mechanical stimulation. (2) Fluoride, a macromolecular material that guides mineralization and blocks dentinal tubules. Fluoride has a good anti-caries effect and is easily absorbed by the hard tissue of the tooth, but it has little effect on relieving dentin sensitivity. Fluoride ions themselves will not block dentinal tubules, but fluoride ions can penetrate and adsorb to the inner wall of dentinal tubules and combine with calcium salts in them to form insoluble compounds such as calcium chloride and fluoroapatite, thereby forming a physical barrier, reducing the diameter of dentinal tubules and sealing dentinal tubules. Although fluoride toothpaste cannot effectively reduce the symptoms of dentin sensitivity caused by mechanical stimulation in subjects, it has a significant improvement effect on the symptoms of dentin sensitivity caused by temperature stimulation. (3) Mineralized composite material that blocks dentinal tubules - hydroxyapatite growth agent (calcium silicate / phosphate). The calcium ions in calcium silicate exchange with the hydrogen ions in the surrounding liquid, resulting in the formation of silicon-hydroxyl groups on its surface. This causes the pH of the surrounding environment to rise and eventually leads to the calcium silicate surface being rich in silicon oxygen anion functional groups and becoming negatively charged. This suggests that the silicon oxygen anion functional groups act as templates at the local pH, thereby facilitating the nucleation and growth of hydroxyapatite. As calcium ions are released in water, the pH value of calcium silicate gradually increases. When calcium ions combine with phosphate ions in the surrounding fluid or saliva, hydroxyapatite is deposited on the surface of calcium silicate. Toothpaste containing calcium silicate / phosphate has a good effect in reducing the sensitivity of dentin to mechanical stimulation (soft teeth when biting hard objects). (4) Direct physical blocking of dentinal tubules - anti-allergic silica. Scanning electron microscopy observation of sensitive dentin and insensitive dentin found that the difference between the two lies in the number of open dentinal tubules and the size of the diameter of the open dentinal tubules. The average number of exposed dentinal tubules per unit area of ​​sensitive dentin is 8 times that of insensitive dentin. The diameter of sensitive dentinal tubules is twice that of insensitive dentinal tubules.The diameter of normal dentinal tubules is generally 2.5μm. Anti-sensitive silica (D50<6μm) can effectively block the tiny tubes on the surface of teeth and block sensitive teeth.

[0031] The anti-sensitive oral care composition of the present application has the following advantages: ① The four-fold anti-dentin sensitivity technology is used to resist dentin sensitivity. Starting from four different anti-sensitivity mechanisms, it can meet the urgent needs of consumers who hope that the product can quickly relieve the phenomenon of cold, hot, sour and soft teeth, continuously mineralize and seal the dentin tubules, and the sensitivity will not recur. ② The abrasive used is biomass calcium silicate. Compared with the traditional silica system, biomass calcium silicate comes from renewable resources such as rice husk ash, bagasse ash, etc., which is low-carbon and environmentally friendly; at the same time, calcium silicate as a calcium-containing abrasive has a slightly weaker cleaning power and is more suitable for people with sensitive teeth; and calcium silicate has good compatibility with fluoride, and the silicon oxygen anion functional group acts as a template at local pH, which is conducive to the nucleation and growth of hydroxyapatite. ③ High-salt anhydrous formula and homogenization process are adopted. Compared with commercially available anti-sensitive toothpaste, the anhydrous formula has a lower heat sensation when used, which reduces the adverse reactions of consumers such as oral debridement when brushing their teeth. At the same time, the introduction of the homogenization process makes the paste more delicate and tastes better.

[0032] In one embodiment, an oral care composition for resisting dentin sensitivity (hereinafter sometimes referred to as "oral care composition") and a method for preparing the same are provided.

[0033] In a specific embodiment, the oral care composition includes an anti-sensitivity agent, and the anti-sensitivity agent includes potassium salt, fluoride, hydroxyapatite growth agent, and anti-sensitivity silica.

[0034] In a specific embodiment, the hydroxyapatite growth agent includes at least one of calcium silicate and phosphate. Preferably, the hydroxyapatite growth agent includes calcium silicate and phosphate. Phosphates include but are not limited to disodium hydrogen phosphate, sodium hydrogen phosphate, and sodium phosphate. Calcium silicate can be biomass calcium silicate, which is derived from renewable resources such as rice husk ash, bagasse ash, etc., and is low-carbon and environmentally friendly.

[0035] In a specific embodiment, the potassium salt includes but is not limited to potassium nitrate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, and potassium fluoride.

[0036] In a specific embodiment, the fluoride includes but is not limited to sodium fluoride, sodium monofluorophosphate, stannous fluoride, potassium fluoride. Preferably, the fluoride is sodium monofluorophosphate.

[0037] In one specific embodiment, the anti-allergic silica is spherical and / or quasi-spherical.

[0038] In a specific embodiment, the particle size of the anti-allergic silicon dioxide is less than 6 μm. For example, the particle size of the anti-allergic silicon dioxide may include 1 μm, 2 μm, 3 μm, 4 μm, 5 μm, and 6 μm. Preferably, the particle size D50 of the anti-allergic silicon dioxide is 2 μm to 5 μm.

[0039] In one embodiment, the oral care composition is an anhydrous oral care composition.

[0040] In a specific embodiment, the oral care composition may include 1 to 50 parts of an anti-sensitizer by weight. For example, the oral care composition may include 1, 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 parts of an anti-sensitizer by weight.

[0041] In a specific embodiment, the oral care composition may include, by weight, 0.01 to 10 parts of potassium salt, 0.1 to 2 parts of fluoride, 0.01 to 30 parts of calcium silicate, 0.01 to 5 parts of phosphate, and 0.1 to 10 parts of anti-allergic silica. For example, by weight, the oral care composition may include: 0.01, 1, 5 or 10 parts of potassium salt, 0.1, 0.5, 1, 1.5 or 2 parts of fluoride, 0.01, 0.1, 0.5, 1, 5, 10, 15, 20, 25 or 30 parts, 0.01, 0.1, 0.5, 1 or 5 parts of phosphate, and 0.1, 0.5, 1, 5 or 10 parts of anti-allergic silica. Preferably, the oral care composition may include, by weight: 0.5 to 5 parts of potassium salt, 0.5 to 1.5 parts of fluoride, 15 to 30 parts of calcium silicate, 1 to 5 parts of phosphate, and 5 to 10 parts of anti-allergic silicon dioxide.

[0042] In a specific embodiment, the oral care composition may include, by weight: 0-5 parts of potassium nitrate, 0.01-30 parts of calcium silicate, 0-5 parts of disodium hydrogen phosphate, 0.76-1.1 parts of sodium monofluorophosphate, and 0-10 parts of anti-allergic silicon dioxide.

[0043] In a specific embodiment, the oral care composition may further include at least one of the following: an abrasive, a thickener, a humectant, a solubilizer, a foaming agent, a sweetener, a flavoring agent, a preservative, and a pigment.

[0044] In a specific embodiment, the friction agent may include at least one of calcium pyrophosphate and abrasive silica. The particle size of the abrasive silica is 5 μm to 20 μm, and the particle size D50 is 10 μm to 15 μm. For example, the particle size of the abrasive silica may include 5 μm, 8 μm, 10 μm, 12 μm, 15 μm, 18 μm, and 20 μm. It should be noted that the particle size may refer to an equivalent diameter.

[0045] In a specific embodiment, the oral care composition may include 0 to 20 parts of abrasive by weight. For example, the oral care composition may include 0, 5, 10, 15 or 20 parts of abrasive by weight. Preferably, the oral care composition may include 1 to 5 parts of abrasive by weight.

[0046] In a specific embodiment, the oral care composition may include at least one of the following, by weight: 0 to 15 parts of calcium pyrophosphate, and 0 to 10 parts of abrasive silica.

[0047] In a specific embodiment, the thickener may include at least one of carboxymethyl cellulose, xanthan gum, and microcrystalline cellulose. Preferably, the thickener is carboxymethyl cellulose and microcrystalline cellulose. It should be noted that microcrystalline cellulose has good fluidity and compressibility, can provide a stable matrix structure for toothpaste, help maintain the uniformity of the paste, and can be conducive to making the extrusion of toothpaste in the tube smoother, less prone to clogging or stratification; sodium carboxymethyl cellulose has water-soluble and high viscosity characteristics, can effectively increase the viscosity of toothpaste, prevent component separation, and maintain the stability and extrusion performance of the paste. Under different ambient temperatures, the combination of microcrystalline cellulose and sodium carboxymethyl cellulose can also help toothpaste maintain a more stable state and reduce the impact of temperature changes on the paste structure. In addition, the anionic form of sodium carboxymethyl cellulose can play a role in blocking the aggregation of microcrystalline cellulose, thereby improving the efficiency of the thickening composition and the stability of the toothpaste.

[0048] In a specific embodiment, the oral care composition may include 0.5 to 2 parts of thickener by weight. For example, the oral care composition may include 0.5, 1, 1.5 or 2 parts of thickener by weight. Preferably, the oral care composition may include 1 to 1.5 parts of thickener by weight.

[0049] In a specific embodiment, the oral care composition may include 0.5 to 2 parts of microcrystalline cellulose and 0.01 to 1 part of sodium carboxymethyl cellulose, by weight.

[0050] In a specific embodiment, the humectant may include at least one of glycerin, propylene glycol, sorbitol, polyethylene glycol, and erythritol.

[0051] In a specific embodiment, the oral care composition may include 30 to 65 parts of a humectant by weight. For example, the oral care composition may include 30, 35, 40, 45, 50, 55, 60 or 65 parts of a humectant by weight. Preferably, the oral care composition may include 40 to 60 parts of a humectant by weight.

[0052] In a specific embodiment, the oral care composition may include at least one of the following, measured by weight: 35 to 60 parts of glycerin, 3 to 5 parts of polyethylene glycol, 3 to 5 parts of propylene glycol, and 0 to 10 parts of erythritol.

[0053] In one embodiment, the solubilizing agent may include polyvinyl pyrrolidone.

[0054] In a specific embodiment, the oral care composition may include 0 to 5 parts of a solubilizer by weight. For example, the oral care composition may include 0, 1, 2, 3, 4 or 5 parts of a solubilizer by weight. Preferably, the oral care composition may include 0 to 1 part of a solubilizer by weight.

[0055] In a specific embodiment, the foaming agent may include at least one of sodium lauryl sulfate, cocamidopropyl betaine, sodium lauroyl sarcosinate, disodium lauroyl glutamate, disodium cocoyl glutamate, sodium methyl lauroyl taurate, sodium methyl cocoyl taurate and sodium cocoyl methyl taurate.

[0056] In a specific embodiment, the oral care composition may include 1 to 5 parts of a foaming agent by weight. For example, the oral care composition may include 1, 2, 3, 4 or 5 parts of a foaming agent by weight. The oral care composition may include 1.5 to 3 parts of a foaming agent by weight.

[0057] In a specific embodiment, the oral care composition may include at least one of the following, by weight: 1.5 to 3 parts of sodium lauryl sulfate, 0.1 to 0.3 parts of cocamidopropyl betaine.

[0058] In a specific embodiment, the sweetener may include at least one of xylitol, sorbitol, mannitol, igloo, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriose, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, sodium cyclamate, alitame, steviol glycosides, arabitol and monk fruit sweetener. The sweetener may also be selected from other edible grade substances, which will not be described in detail herein.

[0059] In a specific embodiment, the oral care composition may include 0.05 to 8 parts of a sweetener by weight. For example, the oral care composition may include 0.05, 0.1, 0.5, 1, 2, 4, 6 or 8 parts of a sweetener by weight. Preferably, the oral care composition may include 0.1 to 0.5 parts of a sweetener by weight.

[0060] In a specific embodiment, the oral care composition may include 0.15 to 0.3 parts by weight of sodium saccharin.

[0061] In a specific embodiment, the fragrance may include at least one of essence, natural essential oil and natural extract, and the essence is an edible essence, which may include at least one of bergamot essence, eucalyptus essence, citrus essence, lemon essence, peppermint essence, mint essence, menthol, licorice essence, wintergreen essence, tobacco essence, coffee essence, vanilla essence, lime essence, apple essence, peach essence, mango essence, cherry essence, blueberry essence, strawberry essence, cola essence, cinnamon essence, vanilla essence and watermelon essence. The essence may also be other types of edible essences, which will not be described in detail herein.

[0062] In a specific embodiment, the oral care composition may include 0.1 to 5 parts of a fragrance by weight. For example, the oral care composition may include 0.1, 0.5, 1, 2, 3, 4 or 5 parts of a fragrance by weight. Preferably, the oral care composition may include 0.5 to 1.5 parts of a fragrance by weight.

[0063] In a specific embodiment, the oral care composition may include 0.8 to 1.2 parts by weight of mint essence.

[0064] In a specific embodiment, the preservative may include at least one of ethylparaben, benzoic acid, sodium benzoate, and potassium sorbate. The preservative may also be selected from other edible-grade antibacterial substances, which will not be described in detail herein.

[0065] In a specific embodiment, the oral care composition may include 0 to 5 parts of preservatives by weight. For example, the oral care composition may include 0, 0.1, 0.5, 1, 2, 3, 4 or 5 parts of preservatives by weight. Preferably, the oral care composition may include 0 to 1.5 parts of preservatives by weight.

[0066] In a specific embodiment, the pigment may include at least one of natural pigment, synthetic pigment, pearl powder (mica), and glitter. The natural pigment includes at least one of titanium dioxide, iron oxide, sodium copper chlorophyllin, and annatto.

[0067] In a specific embodiment, the oral care composition may include 0.01 to 1 parts of pigment by weight. For example, the oral care composition may include 0.01, 0.05, 0.1, 0.5 or 1 parts of pigment by weight. Preferably, the oral care composition may include 0.01 to 0.3 parts of pigment by weight.

[0068] In a specific embodiment, the oral care composition may include 0.01 to 0.3 parts by weight of titanium dioxide.

[0069] In a specific embodiment, the preparation method of the oral care composition may include: step S1: preparing glue, heating and stirring a thickener and a moisturizer to obtain glue; step S2: preparing a paste, adding an anti-allergic agent, heating and stirring, adding the remaining components, stirring at room temperature, and degassing to obtain a paste, i.e., an oral care composition.

[0070] In a specific embodiment, in step S1, the heating and stirring conditions may include: heating to 60°C to 90°C, stirring rate 2000 to 12000 rpm / min, and stirring time 10 to 60 min.

[0071] In a specific embodiment, in step S2, the heating and stirring conditions may include: heating to 50°C to 65°C, a stirring rate of 500 to 10000 rpm / min, and a stirring time of 5 to 40 min.

[0072] In a specific embodiment, in step S1 and step S2, a homogenizer may be used to achieve stirring.

[0073] The present application is further described in detail below by specific examples and comparative examples. The following examples and comparative examples are only used to further illustrate the present application and should not be construed as limiting the present application. In the present embodiment, unless otherwise specified, the technical means used are conventional means known to those skilled in the art, and the materials, reagents, etc. used can be obtained from commercial sources.

[0074] (1) Anti-allergic silica

[0075] The anti-allergic silica used in this embodiment is spherical or quasi-spherical, and the particle size D50 is 3.1 μm. Take 5 g of anti-allergic silica, add deionized water to 100 g and stir at 300 rpm to obtain an anti-allergic silica dispersion; immerse a dentin sensitive tooth sample in the dispersion, take out the tooth sample after 60 seconds, wash it with deionized water for 10 seconds, and scan the surface of the tooth sample with a scanning electron microscope (SEM). Figure 1 This is a scanning electron microscope image of the tooth sample surface before treatment with anti-allergic silica dispersion. Figure 2This is a scanning electron microscope image of the surface of a tooth sample treated with an anti-allergic silica dispersion. Figure 1 and Figure 2 It can be seen that the silicon dioxide with a specific shape and particle size used in this embodiment can effectively block the dentinal tubules of dentin-sensitive teeth.

[0076] (2) Oral care compositions of various embodiments and comparative examples:

[0077] According to the formula of Table 1 below, the oral care compositions of each embodiment and the compositions of each comparative example are prepared, and the preparation method is as follows: the first step is the preparation of glue: weigh microcrystalline cellulose, sodium carboxymethyl cellulose, sodium saccharin (sucralose) and part of glycerol and disperse them evenly, heat to 75°C, use a homogenizer at 5000rpm / min, homogenize for 30min, cool to room temperature, and obtain glue for use. The second step is the paste making process: weigh a certain amount of glue in a beaker, add potassium nitrate, sodium monofluorophosphate, disodium hydrogen phosphate, polyvinyl pyrrolidone, heat to 60°C, use a homogenizer at 5000rpm / min, homogenize for 5min, add propylene glycol, polyethylene glycol and the remaining glycerol (or water) after full swelling and uniformity, and then add the remaining powders in the formula (in no order), use a propeller mixing device to stir at 1000rpm / min for 30min at room temperature until the paste is fine and uniform, and vacuum degas to obtain a toothpaste paste.

[0078] Table 1

[0079]

[0080] Performance Test:

[0081] ① Stability observation

[0082] The stability of the oral care compositions of the embodiments and comparative examples was observed at room temperature and 45°C, with reference to GB 8372-2017 Toothpaste. The experimental results are shown in Table 2 below, where the left side of " / " in Table 2 is the test results at room temperature, and the right side of " / " is the test results at 45°C; "not forming strips" means that after the paste is squeezed out, it cannot maintain a strip shape because the paste is thin, and collapse occurs; "thin paste" means that the paste has low viscosity and is difficult to form, and is closer to a fluid (thinner) than the paste in the "not forming strips" case; "hard" and "hardened" both mean that the paste viscosity increases, "hard" means that the paste viscosity is slightly increased, and "hardened" means that the paste viscosity is greater than 600kpa·s.

[0083] Table 2

[0084]

[0085] As can be seen from Table 2, the stability of the oral care compositions prepared in Examples 1 to 4 is good. Comparative Example 1 contains 3% water compared with Example 1. The paste gradually hardens at room temperature, and the 45°C test sample slowly hardens. The formula of Comparative Example 1 contains water and is a high salt system (phosphate). The solubility of high salt at room temperature is reduced, and the salt particles precipitate out of the paste and are hard. The gradual hardening of the late sample indicates that the formula system is unstable and a chemical reaction occurs, indicating that calcium silicate also produces calcium ions in a very small aqueous solution, and can react chemically with phosphate to produce hydroxyapatite. Comparative Example 2 contains 3% water compared with Example 1, and does not contain phosphate. The 45°C test sample gradually hardens in 1 month, indicating that calcium silicate and sodium monofluorophosphate will slowly react chemically under water conditions, and calcium fluoride may be formed, resulting in fluorine inactivation. Comparative Example 3 The paste prepared with carbomer as a thickener is not formed, indicating that carbomer is not resistant to homogenization under this process condition and cannot play the role of a thickener. Comparative Example 4 contains a high content of polyethylene glycol, which has little effect on the stability of the paste and only slightly causes liquid discharge.

[0086] ②Fluorine content test

[0087] The soluble fluorine content of the embodiment was measured according to the national standard GB / T 8372-2017 "Toothpaste" 5.8, and the total fluorine content of the embodiment and was measured according to the national standard GB / T 8372-2017 "Toothpaste" 5.9. The experimental results are shown in Table 3.

[0088] Table 3

[0089]

[0090]

[0091] As can be seen from the table above, the soluble fluoride content of Examples 1-4 has no obvious decay over time, indicating that the fluoride stability in the oral care compositions of Experimental Examples 1-4 is normal. Comparative Example 1-2 is affected by the aqueous system, and the fluoride decays significantly.

[0092] ③Observation of clinical effect of anti-dentin hypersensitivity

[0093] The oral care composition prepared according to the formula of Example 1 was used as a test group to evaluate the anti-dentin sensitivity effect, and pure water was used as a control group.

[0094] Experimental methods:

[0095] 1. The subjects were healthy adult males and females who met the inclusion and exclusion criteria. A total of 70 eligible subjects participated in the baseline examination, and 69 subjects completed the full cycle of the study.

[0096] 2. Inclusion criteria: Age between 19 and 52 years old; good general health; available for examination at any time during the trial; first check the condition of teeth and gums, and should have at least two teeth that meet the research standards; no allergic reaction to toothpaste and its ingredients; no use of other anti-allergic toothpaste; no colleagues participating in other similar experimental studies; no use of medication in the month before participating in the study.

[0097] The experimental results are shown in Tables 4 and 5. Table 4 shows the evaluation results of the probing sensitivity, and Table 5 shows the evaluation results of the cold air blowing sensitivity.

[0098] Table 4

[0099]

[0100]

[0101] Table 5

[0102]

[0103] As shown in Tables 4 and 5, after using the test group product for 1 week, the probe sensitivity evaluation decreased by 4.98%, and the cold air blowing sensitivity evaluation decreased by 2.45%; after using the product for 2 weeks, the probe sensitivity evaluation decreased by 15.42%, and the cold air blowing sensitivity evaluation decreased by 14.22%; after using the product for 4 weeks, the probe sensitivity evaluation decreased by 23.88%, and the cold air blowing sensitivity evaluation decreased by 26.47%. Among them, the significant results of the probe sensitivity evaluation and the cold air blowing sensitivity evaluation for 2 weeks and 4 weeks in the test group were significantly better than those in the control group (p<0.05), indicating that the oral care composition of Example 1 has a significant anti-dentin hypersensitivity effect after 2 weeks of use.

[0104] The above contents are further detailed descriptions of the present application in combination with specific implementation methods, and it cannot be determined that the specific implementation of the present application is limited to these descriptions. For ordinary technicians in the technical field to which the present application belongs, several simple deductions or substitutions can be made without departing from the concept of the present application.

Claims

1. An oral care composition for resisting dentin hypersensitivity, characterized in that: The invention comprises an anti-allergic agent, wherein the anti-allergic agent comprises potassium salt, fluoride, hydroxyapatite growth agent and anti-allergic silicon dioxide.

2. The oral care composition according to claim 1, characterized in that The hydroxyapatite growth agent includes at least one of calcium silicate and phosphate; Preferably, the oral care composition is an anhydrous oral care composition.

3. The oral care composition according to claim 1, characterized in that The potassium salt includes but is not limited to potassium nitrate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium fluoride, and the fluoride includes but is not limited to sodium fluoride, sodium monofluorophosphate, stannous fluoride, and potassium fluoride.

4. The oral care composition according to claims 1 to 3, characterized in that The anti-allergic silicon dioxide is spherical and / or quasi-spherical; Preferably, the particle size of the anti-allergic silica is less than 6 μm; Preferably, the particle size D50 of the anti-allergic silica is 2 μm to 5 μm.

5. The oral care composition according to claim 4, characterized in that In parts by weight, the oral care composition comprises: 0.01 to 10 parts of the potassium salt, 0.1 to 2 parts of the fluoride, 0.01 to 30 parts of the calcium silicate, 0.01 to 5 parts of the phosphate, and 0.1 to 10 parts of the anti-allergic silicon dioxide.

6. The oral care composition according to claim 5, characterized in that The oral care composition further comprises at least one of the following: an abrasive, a thickener, a humectant, a solubilizer, a foaming agent, a sweetener, a fragrance, and a pigment.

7. The oral care composition according to claim 6, characterized in that The friction agent includes at least one of calcium pyrophosphate and abrasive silica; Preferably, the particle size of the abrasive silica is 5 μm to 20 μm, and the particle size D50 is 10 μm to 15 μm.

8. The oral care composition according to claim 6 or 7, characterized in that In parts by weight, the oral care composition comprises at least one of the following: 1 to 50 parts of the antisensitizer, 0 to 20 parts of the abrasive, 0.5 to 2 parts of the thickener, 30 to 65 parts of the moisturizer, 1 to 5 parts of the foaming agent, 0 to 5 parts of the solubilizer, 0.05 to 8 parts of the sweetener, 0.1 to 5 parts of the fragrance, and 0 to 1 part of the pigment.

9. The oral care composition according to claim 7, characterized in that The oral care composition comprises, by weight: 0.5 to 5 parts of the potassium salt, 0.5 to 1.5 parts of the fluoride, 15 to 30 parts of the calcium silicate, 1 to 5 parts of the phosphate, 5 to 10 parts of the anti-allergic silicon dioxide, 1 to 5 parts of the abrasive, 1 to 1.5 parts of the thickener, 40 to 60 parts of the moisturizer, 1.5 to 3 parts of the foaming agent, 0 to 1 part of the solubilizer, 0.1 to 0.5 parts of the sweetener, 0.5 to 1.5 parts of the fragrance, and 0.01 to 0.3 parts of the pigment.

10. A method for preparing the oral care composition according to any one of claims 1 to 9, characterized in that: include: Preparation of glue: heating and stirring the thickener and the moisturizer to obtain glue; Preparation of paste: adding an anti-sensitizer, heating and stirring, adding other components, stirring at room temperature, and degassing to obtain a paste, namely the oral care composition.

Images