Oral care composition and preparation method thereof

Abstract

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises zinc glycinate and a phosphate chelating agent, the mass percentage of the zinc glycinate is 0.05-1%, the mass percentage of the phosphate chelating agent is 0.1-5%, and the mass ratio of the phosphate chelating agent to the zinc glycinate is greater than or equal to 2: 1. According to the invention, the oral care composition with good formula stability and high transparency can be provided.

Description

Technical Field

[0001] The present application relates to the technical field of daily chemical product production, and in particular to an oral care composition and a preparation method thereof. Background Art

[0002] Oral health is an important part of overall health and directly affects an individual's quality of life and social interaction. Poor oral hygiene may lead to a variety of problems, such as caries, gingivitis, periodontal disease, bad breath, etc. In order to maintain oral health, consumers are increasingly relying on various oral care products, such as toothpaste, mouthwash, mouth spray, etc. These products not only help clean teeth and mouth, but also prevent diseases, improve breath, whiten teeth, etc.

[0003] In oral products with breath freshening function, zinc ions (mainly zinc citrate, zinc oxide, etc.) are often used as breath fresheners. Zinc ions can inhibit bacterial metabolism and reduce the production of volatile sulfides (VSCs) by binding to the surface of bacteria, but they cannot immediately remove the odor molecules that have already been produced. In addition, zinc citrate and zinc oxide have low solubility in water. If they are not fully dissolved in the formula, they may lead to problems such as unstable formula and physical instability of the product (such as precipitation and stratification). Especially in high-transparency oral care products (such as mouthwash, transparent toothpaste, etc.), the solubility of the ingredients will also directly affect the transparency of the product. Summary of the invention

[0004] In order to overcome the deficiencies of the prior art and solve the problem that the breath freshener in the oral care products of the prior art has low solubility, affecting the formula stability and product transparency, the present application provides an oral care composition with good formula stability and high transparency and a preparation method thereof.

[0005] This application adopts the following technical solutions:

[0006] On the one hand, the present application discloses an oral care composition, comprising zinc glycinate and a phosphate chelating agent. In the oral care composition, the mass percentage of the zinc glycinate is 0.05% to 1%, the mass percentage of the phosphate chelating agent is 0.1% to 5%, and the mass ratio of the phosphate chelating agent to the zinc glycinate is greater than or equal to 2:1.

[0007] It should be noted that zinc glycinate, as a breath freshener, has a higher solubility than zinc citrate or zinc oxide, which can help improve the formula stability and product transparency; and zinc glycinate can not only inhibit bacterial metabolism through zinc ions and reduce the production of volatile sulfides (VSCs), but also can combine ammonia, acid and aldehyde odor molecules through the amino group (-NH2) and carboxyl group (-COOH) contained in zinc glycinate, thereby playing a role in quickly removing bad breath and immediate freshness. In this application, by using an appropriate amount of zinc glycinate, a good deodorizing effect can be achieved, and the product has good transparency. Phosphate chelating agents can chelate metal ions, and by chelating zinc ions in zinc glycinate, it can help improve the transparency of the product. In this application, by using an appropriate amount of phosphate chelating agents, it can assist in promoting the dissolution of zinc glycinate, so that the product has good transparency. The applicant found that when the mass ratio of phosphate chelating agents to zinc glycinate is ≥2:1, the complete dissolution of zinc glycinate can be met, ensuring the transparency of the oral care composition.

[0008] In addition, phosphate chelators have the effect of whitening teeth and preventing pigment deposition. Specifically, phosphate chelators chelate calcium ions in saliva to prevent the formation of calcium-phosphorus precipitates, thereby reducing the deposition of tartar and preventing the formation of early tartar. By inhibiting the formation of tartar, polyphosphates can help keep the tooth surface smooth and clean, reduce the chance of pigment deposition, and make teeth look whiter; for early teeth that have already formed, phosphate chelators can combine with calcium-phosphorus precipitates in early tartar and dissolve them into soluble complexes, helping to remove dirt and pigments on the tooth surface and further improve the appearance of teeth.

[0009] In one implementation of the present application, the mass percentage of the zinc glycinate is 0.1% to 0.5%, and the mass percentage of the phosphate chelating agent is 0.5% to 3%.

[0010] In one implementation of the present application, the phosphate chelating agent includes at least one of polyphosphate and phytate, and the polyphosphate includes at least one of pyrophosphate, tripolyphosphate, tetrapolyphosphate, hexametaphosphate and polyphosphate.

[0011] In one implementation of the present application, the pyrophosphate includes at least one of tetrasodium pyrophosphate (Na4P2O7), sodium pyrophosphate (Na2H2P2O7), and tetrapotassium pyrophosphate (K4P2O7), and the tripolyphosphate includes pentasodium tripolyphosphate (Na5P3O 10 ), at least one of pentapotassium tripolyphosphate; the tetrapolyphosphate comprises at least one of sodium tetrapolyphosphate and potassium tetrapolyphosphate, the polyphosphate comprises sodium polyphosphate ((NaPO3) n, wherein n represents the number of phosphate units, n is greater than 6), potassium polyphosphate; the hexametaphosphate includes at least one of sodium hexametaphosphate ((NaPO3)6) and potassium hexametaphosphate; the phytate includes sodium phytate (Na6(C6H 18 O 24 P6)), at least one of potassium phytate.

[0012] In one implementation of the present application, the phosphate chelating agent includes at least one of tetrasodium pyrophosphate, tetrapotassium pyrophosphate, pentasodium tripolyphosphate, sodium hexametaphosphate, and sodium phytate. It should be noted that these phosphate chelating agents are easy to obtain, have high solubility, and have good chelating effect, which is beneficial to improve the transparency of the zinc glycinate-containing product.

[0013] In one implementation of the present application, the oral care composition includes at least one of a mouthwash, a toothpaste and a mouth spray.

[0014] In one implementation of the present application, the abrasive of the toothpaste is hydrated silica. It should be noted that hydrated silica (Hydrated Silica, SiO2·nH2O) is an amorphous silicon dioxide that is hydrated to form tiny particles, which can be evenly dispersed in a transparent matrix (such as glycerin, sorbitol, etc.), reducing the impact on the transparency of the toothpaste. In addition, hydrated silica as an abrasive can provide a moderate intensity friction cleaning effect that can effectively remove dirt and plaque on the surface of the teeth, but will not cause excessive wear on the enamel. Hydrated silica can also be used as a thickener and suspending agent to help maintain the uniform texture of the toothpaste, prevent other ingredients from settling or stratifying, and help maintain the stability and aesthetics of the product.

[0015] In one implementation of the present application, the particle size D50 of the hydrated silica is 10 μm to 15 μm.

[0016] In one implementation of the present application, the refractive index of the hydrated silica is 1.437 to 1.464. It should be noted that in a multiphase system (such as a toothpaste containing multiple ingredients), transparency depends not only on the refractive index of a single ingredient, but also on the difference in refractive index between the ingredients. The refractive index of the hydrated silica in the present application is 1.437 to 1.464, which is close to the refractive index of the aqueous phase in the oral care composition of the present application. When the refractive indices of the two media are close, light will not be significantly refracted or scattered at the interface between the two, which is conducive to maintaining the transparency of the toothpaste.

[0017] In one implementation of the present application, the refractive index of the hydrated silica is 1.449-1.456.

[0018] In one implementation of the present application, the toothpaste further includes at least one of the following: a thickener, a humectant, a foaming agent, a preservative, a fragrance, a sweetener, and a cooling agent.

[0019] In one implementation of the present application, the thickener includes at least one of the following: thickening hydrated silica, highly transparent xanthan gum, highly transparent carrageenan, cellulose gum; the moisturizer includes at least one of the following: sorbitol, glycerol, propylene glycol, PEG-8. It should be noted that in the present application, by selecting thickeners and moisturizers with high solubility in water and good transparency, avoiding the use of opaque thickeners or moisturizers that easily cause turbidity, such as high molecular weight PEG, etc., it can help to obtain an oral care composition with good formula stability and high transparency.

[0020] In one implementation of the present application, the toothpaste comprises, by weight: 5 to 30 parts of the hydrated silica, 2 to 10 parts of the thickener, 5 to 70 parts of the moisturizer, 1 to 3 parts of the foaming agent, 0.05 to 0.5 parts of the zinc glycinate, 0.5 to 5 parts of the phosphate chelating agent, and 6 to 20 parts of water. It should be noted that under this system, the refractive index of the liquid phase in the toothpaste is close to that of the powder phase, and a toothpaste with high transparency can be provided.

[0021] On the other hand, the present application discloses a method for preparing an oral care composition, comprising: adding zinc glycinate and a phosphate chelating agent into water at 50° C. to 60° C. and stirring; adding other components and stirring to obtain the oral care composition.

[0022] The beneficial effects of this application are:

[0023] The oral care composition of the present application contains zinc glycinate as a breath freshener, which has a higher solubility than zinc citrate or zinc oxide, and can help improve the formula stability and product transparency; and zinc glycinate can not only inhibit bacterial metabolism through zinc ions and reduce the production of volatile sulfides (VSCs), but also can combine ammonia, acid and aldehyde odor molecules through the amino group (-NH2) and carboxyl group (-COOH) contained in zinc glycinate, thereby playing a role in quickly removing bad breath and immediate freshness. In the present application, by using an appropriate amount of zinc glycinate, a good deodorizing effect can be achieved, and the product has good transparency. Phosphate chelating agents can chelate metal ions, and by chelating zinc ions in zinc glycinate, it can help improve the transparency of the product. In the present application, by using an appropriate amount of phosphate chelating agents, it can assist in promoting the dissolution of zinc glycinate, so that the product has good transparency. The applicant found that when the mass ratio of phosphate chelating agents to zinc glycinate is ≥2:1, the complete dissolution of zinc glycinate can be met, ensuring the transparency of the oral care composition. In addition, phosphate chelators have the effect of whitening teeth and preventing pigment deposition. Specifically, phosphate chelators chelate calcium ions in saliva to prevent the formation of calcium-phosphorus precipitates, thereby reducing the deposition of tartar and preventing the formation of early tartar. By inhibiting the formation of tartar, polyphosphates can help keep the tooth surface smooth and clean, reduce the chance of pigment deposition, and make teeth look whiter; for early teeth that have already formed, phosphate chelators can combine with calcium-phosphorus precipitates in early tartar and dissolve them into soluble complexes, helping to remove dirt and pigments on the tooth surface and further improve the appearance of teeth.

[0024] In summary, the oral care composition of the present application can have a good breath freshening effect, and the components have good solubility, thereby enabling the formula to have good stability and the product to have good transparency. DETAILED DESCRIPTION

[0025] The present invention is further described in detail below by specific embodiments. In the following embodiments, many details are described in order to make the present application better understood. However, those skilled in the art can recognize without difficulty that some features can be omitted in different situations, or can be replaced by other materials and methods. In some cases, some operations related to the present application are not shown or described in the specification, and this is to avoid the core part of the present application from being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0026] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0027] Most existing oral products for fresh breath use zinc ions (mainly insoluble zinc salts such as zinc citrate and zinc oxide) to inhibit bacteria, reduce the reproduction of microorganisms in the oral cavity, and thus inhibit the production of VSCs, but cannot immediately eliminate the VSCs that have already been produced. In addition, zinc citrate, zinc oxide, etc. have poor solubility in water, which may lead to problems such as unstable formulations and physical instability of products (such as precipitation and stratification); especially in high-transparency oral care products (such as mouthwash, transparent toothpaste, etc.), the solubility of the ingredients will also directly affect the transparency of the product. Based on this, the present application compounds zinc glycinate and phosphate chelating agents, and phosphate assists in promoting the dissolution and transparency of zinc glycinate, which can be used in conventional toothpaste, transparent toothpaste, as well as mouthwash, mouth spray, etc.

[0028] The present application relates to an oral care composition and a preparation method thereof.

[0029] In a specific embodiment, the oral care composition may include at least one of a mouthwash, a toothpaste and a mouth spray. Mouthwash is a liquid oral care product used for gargling, which can be used to help clean the oral cavity, remove food residues, reduce bacteria and eliminate bad breath, etc. Mouth spray is a portable oral care product, usually provided in the form of an aerosol, and is mainly used to quickly freshen breath, cover up odor or provide temporary oral care.

[0030] In a particular embodiment, the oral care composition may include zinc glycinate and a phosphate chelating agent.

[0031] In a specific embodiment, the phosphate chelating agent may include at least one of polyphosphate and phytate.

[0032] In a specific embodiment, the polyphosphate may include at least one of pyrophosphate, tripolyphosphate, tetrapolyphosphate, hexametaphosphate and polyphosphate. Pyrophosphate may include at least one of tetrasodium pyrophosphate, sodium pyrophosphate and tetrapotassium pyrophosphate. Tripolyphosphate may include at least one of pentasodium tripolyphosphate and pentapotassium tripolyphosphate. Tetrapolyphosphate may include at least one of sodium tetrapolyphosphate and potassium tetrapolyphosphate. Polyphosphate may include at least one of sodium polyphosphate and potassium polyphosphate. Hexametaphosphate may include at least one of sodium hexametaphosphate and potassium hexametaphosphate. Phytate may include at least one of sodium phytate and potassium phytate.

[0033] In a specific embodiment, the phosphate chelating agent may include at least one of tetrasodium pyrophosphate, tetrapotassium pyrophosphate, pentasodium tripolyphosphate, sodium hexametaphosphate, and sodium phytate.

[0034] In a specific embodiment, the mass percentage (w / w) of zinc glycinate in the oral care composition may be 0.05% to 1%. For example, the mass percentage of zinc glycinate in the oral care composition may be 0.05%, 0.1%, 0.25%, 0.5%, 0.75% or 1%. Preferably, the mass percentage of zinc glycinate in the oral care composition is 0.1% to 0.5%.

[0035] In a specific embodiment, the mass percentage (w / w) of the phosphate chelating agent in the oral care composition may be 0.1% to 5%. For example, the mass percentage of the phosphate chelating agent in the oral care composition may be 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5%. Preferably, the mass percentage of the phosphate chelating agent in the oral care composition is 0.5% to 3%.

[0036] In a specific embodiment, in the oral care composition, the mass ratio of the phosphate chelating agent to zinc glycinate may be ≥ 2: 1. For example, the mass ratio of the phosphate chelating agent to zinc glycinate may be 2: 1, 2.5: 1, 3: 1, 4: 1, 6: 1, 6: 1, 7: 1 or 8: 1.

[0037] In a specific embodiment, in the oral care composition, the mass ratio of the phosphate chelating agent to zinc glycinate may be ≤5:1.

[0038] In a specific embodiment, the oral care composition does not contain metal ions such as calcium ions and magnesium ions, thereby facilitating the chelation effect of the phosphate chelating agent on zinc glycinate.

[0039] In a specific embodiment, a toothpaste with high transparency is provided, which comprises the zinc glycinate and the phosphate chelating agent as described above, and the description of the zinc glycinate and the phosphate chelating agent can be referred to the above content, which will not be repeated here.

[0040] In one embodiment, the abrasive of the toothpaste is hydrated silica.

[0041] In a specific embodiment, the refractive index of the hydrated silica is 1.437-1.464.

[0042] In a specific embodiment, the refractive index of the hydrated silica is 1.449-1.456.

[0043] In a specific embodiment, the particle size D50 of the hydrated silica may be 8-13 μm. For example, the particle size D50 of the hydrated silica may be 8 μm, 9 μm, 10 μm, 11 μm, 12 μm or 13 μm.

[0044] In a specific embodiment, the toothpaste further comprises at least one of the following: a thickener, a humectant, a foaming agent, a preservative, a fragrance, a sweetener, and a cooling agent.

[0045] In a specific embodiment, the thickener may include at least one of thickening hydrated silica, high-transparency xanthan gum, high-transparency carrageenan, and cellulose gum. It should be noted that thickening hydrated silica, high-transparency xanthan gum, high-transparency carrageenan, and cellulose gum can be obtained from the market and are high-transparency products, and their specific product models are not limited.

[0046] In a specific embodiment, the moisturizer may include at least one of sorbitol, glycerin, propylene glycol, and PEG-8.

[0047] In a specific embodiment, the foaming agent may include at least one of sodium lauryl sulfate (k12), sodium laureth sulfate, dodecyl dimethylamine oxide, sodium lauryl sulfate, cocamidopropyl betaine, sodium lauroyl sarcosinate, disodium lauroyl glutamate, disodium cocoyl glutamate, sodium methyl lauroyl taurate, sodium methyl cocoyl taurate, and sodium cocoyl methyl taurate. Preferably, the foaming agent includes at least one of sodium lauryl sulfate, sodium laureth sulfate, dodecyl dimethylamine oxide, and cocamidopropyl betaine. It should be noted that the higher solubility of the foaming agent in water is conducive to ensuring the transparency of the toothpaste.

[0048] In a specific embodiment, the preservative may include ethylparaben, benzoic acid, sodium benzoate, potassium sorbate. The preservative may also be selected from other edible grade antibacterial substances, which will not be described in detail herein.

[0049] In a specific embodiment, the fragrance may include at least one of essence, natural essential oil and natural extract, and the essence is an edible essence, which may include at least one of bergamot essence, eucalyptus essence, citrus essence, lemon essence, peppermint essence, mint essence, menthol, licorice essence, wintergreen essence, tobacco essence, coffee essence, vanilla essence, lime essence, apple essence, peach essence, mango essence, cherry essence, blueberry essence, strawberry essence, cola essence, cinnamon essence, vanilla essence and watermelon essence. The essence may also be other types of edible essences, which will not be described in detail herein.

[0050] In a specific embodiment, the sweetener may include at least one of xylitol, sorbitol, mannitol, igloo, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriose, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, sodium cyclamate, alitame, steviol glycosides, arabitol and monk fruit sweetener. The sweetener may also be selected from other edible grade substances, which will not be described in detail herein.

[0051] In a specific embodiment, the cooling agent may include at least one of menthol, menthol derivatives, WS-3 and WS-23.

[0052] In a specific embodiment, the toothpaste may include 5 to 30 parts by weight of hydrated silica. For example, the toothpaste may include 5, 10, 15, 20, 25 or 30 parts by weight of hydrated silica.

[0053] In a specific embodiment, the toothpaste may include 2 to 10 parts of thickener by weight. For example, the toothpaste may include 2, 4, 6, 8 or 10 parts of thickener by weight.

[0054] In a specific embodiment, the toothpaste may include 5 to 70 parts of the humectant by weight. For example, the toothpaste may include 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65 or 70 parts of the humectant by weight.

[0055] In a specific embodiment, the toothpaste may include 1 to 3 parts of foaming agent by weight. For example, the toothpaste may include 1, 1.5, 2, 2.5 or 3 parts of foaming agent by weight.

[0056] In a specific embodiment, the toothpaste may include 0.05-0.5 parts of zinc glycinate by weight. For example, the toothpaste may include 0.05, 0.1, 0.2, 0.3, 0.4 or 0.5 parts of zinc glycinate by weight.

[0057] In a specific embodiment, the toothpaste may include 0.5 to 5 parts by weight of a phosphate chelating agent. For example, the toothpaste may include 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5 parts by weight of a phosphate chelating agent.

[0058] In a specific embodiment, the toothpaste may include 6 to 20 parts of water by weight. For example, the toothpaste may include 6, 8, 10, 12, 14, 16, 18 or 20 parts of water by weight.

[0059] In a specific embodiment, a highly transparent mouthwash or mouth spray is provided. The mouthwash or mouth spray comprises the zinc glycinate and the phosphate chelating agent as described above. The mouthwash or mouth spray may also comprise at least one of water, an antibacterial agent, a solubilizing agent, a moisturizing agent, a sweetener, a fragrance, a preservative, and a cooling agent. The moisturizing agent, the sweetener, the fragrance, the preservative, and the cooling agent may refer to the aforementioned content and will not be described in detail here.

[0060] In a specific embodiment, the antibacterial agent may include at least one of the following: chlorhexidine, fluoride, triclosan; used to inhibit harmful bacteria in the oral cavity and prevent gingivitis, periodontal disease, etc.

[0061] In a specific embodiment, the solubilizer may include at least one of the following: PEG-40 hydrogenated castor oil, poloxamer, and cyclodextrin.

[0062] In a specific embodiment, the mouthwash may include 20 to 90 parts of water by weight. For example, the mouthwash may include 20, 30, 40, 50, 60, 70, 80 or 90 parts of water by weight.

[0063] In a specific embodiment, the mouthwash may include 0.02-0.1 parts by weight of the antibacterial agent. For example, the mouthwash may include 0.02, 0.05, 0.075 or 0.1 parts by weight of the antibacterial agent.

[0064] In a specific embodiment, the mouthwash may include 5 to 30 parts by weight of the moisturizer. For example, the mouthwash may include 5, 10, 15, 20, 25 or 50 parts by weight of the moisturizer.

[0065] In a specific embodiment, the mouthwash may include 0.05-0.15 parts of sweetener by weight. For example, the mouthwash may include 0.05, 0.075, 0.1, 0.125 or 0.15 parts of sweetener by weight.

[0066] In a specific embodiment, the mouthwash may include 1 to 8 parts of the solubilizer by weight. For example, the mouthwash may include 1, 2, 3, 4, 5, 6, 7 or 8 parts of the solubilizer by weight.

[0067] In a specific embodiment, the mouthwash may include 0.06-0.5 parts of fragrance by weight. For example, the mouthwash may include 0.06, 0.1, 0.2, 0.3, 0.4 or 0.5 parts of fragrance by weight.

[0068] In a specific embodiment, the mouthwash may include 0.1 to 1 parts of preservatives by weight. For example, the mouthwash may include 0.1, 0.3, 0.5, 0.8 or 1 parts of preservatives by weight.

[0069] In a specific embodiment, the mouthwash may include 0.05 to 2 parts of the cooling agent by weight. For example, the mouthwash may include 0.05, 0.075, 0.1, 0.15 or 0.2 parts of the cooling agent by weight.

[0070] As described above, the present application relates to a method for preparing an oral care composition. The preparation method may include: adding zinc glycinate and a phosphate chelating agent to water at 50°C to 60°C and stirring (step S1); adding the remaining components and stirring to prepare the oral care composition (step S2).

[0071] In a specific embodiment, in step S1, the stirring conditions may be: stirring speed 2000-12000 r / min, stirring time 1-10 min.

[0072] In a specific embodiment, in step S2, stirring can be performed at room temperature. The stirring conditions can be: stirring speed 1000-10000 r / min, stirring time 10-60 min.

[0073] The present application is further described in detail below by specific examples and comparative examples. The following examples and comparative examples are only used to further illustrate the present application and should not be construed as limiting the present application. In the present embodiment, unless otherwise specified, the raw materials, reagents, and instruments used are all commercially available, and the experimental operations are carried out in accordance with the product instructions and conventional experimental specifications.

[0074] (1) Ratio and transparency of zinc glycinate and phosphate complexing agent:

[0075] Prepare the solution according to the table below. Stir at 1000 rpm for 5 minutes at 50℃~60℃, and observe whether the appearance of different groups is clear. "-" means that the ingredient is not added:

[0076]

[0077] As can be seen from the table above, in aqueous solution, zinc glycinate is difficult to dissolve when the content is 0.2%, and the appearance is turbid and unclear. By adding an appropriate amount of phosphate complexing agent, when the mass ratio of phosphate complexing agent to zinc glycinate is ≥2:1, it can help zinc glycinate to be fully dissolved.

[0078] (2) Mouthwash and its transparency:

[0079] Mix the components according to the table below (PEG-40 hydrogenated castor oil and essence are premixed), and then mix the following ingredients and stir at 1000 rpm for 5 minutes at 50°C to 60°C to prepare a mouthwash:

[0080]

[0081] (3) Toothpaste:

[0082] Prepare toothpaste according to the table below. First, add some water, control the water temperature at 55°C, then add zinc glycinate and phosphate chelating agent, stir evenly, then add moisturizer and sweetener, then add abrasive, thickener and other ingredients, stir at 1000r / min under vacuum until the thickener is fully swollen, deaerate, and obtain toothpaste paste. The unit of the amount of each ingredient in the table is gram (g).

[0083]

[0084] Efficacy test:

[0085]

[0086] Among them, the transmittance measurement method is: use a spectrophotometer, control sample: put deionized water into a transparent cuvette, and the liquid level can be slightly lower than the edge of the glass; test sample: squeeze the toothpaste sample to be tested into the cuvette from bottom to top, pay attention to expel the air in the paste when squeezing, and the amount of paste squeezed in can be slightly lower than or flush with the edge of the glass, select a wavelength of 589nm for testing, and record the maximum transmittance.

[0087] Method for measuring the effect of removing bad breath: simulate a mouth full of garlic smell: chew 2g of garlic paste before each test to ensure that the mouth is full of garlic smell. Use HalimeterPLUS breath detector to test and record the value V1. After each group of test members brush their teeth with the test toothpaste, use HalimeterPLUS breath detector to test and record the value V2. Effect of removing bad breath (%) = (V1-V2)*100% / V1.

[0088] Method for measuring the effect of blocking pigments: 1. Prepare a solution with a volume ratio of gastric mucosal protein solution: artificial saliva = 1:1, wherein the content of gastric mucosal protein in the gastric mucosal protein solution is 0.01g / L. The preparation method of artificial saliva is: take NaCl0.67g, KCl 0.2g, CaCl20.2g, Na2HPO40.2g, urea 0.1g, Na2S0.01g, distilled water to 1L, adjust the pH to 6.0-6.1; then put the HAP sheet (hydroxyapatite sheet) into the prepared solution and soak for 1h. 2. Take 0.5g of toothpaste, apply it evenly on the HAP sheet, brush it with a toothbrush for 2min; wash the HAP sheet with clean water until there is no toothpaste residue; test the whiteness L0. At the same time, test the whiteness of the blank HAP sheet, which is recorded as L0 blank. Put a bag of coffee and a bag of tea into 500g of water, boil it, soak it for 10min, and filter it to obtain the simulated color stain filtrate for use. Take 25g of the stain filtrate, soak the blank HAP sheet and the experimental HAP sheet in it for 3 minutes respectively, take them out and rinse them with clean water, and use a colorimeter to measure the whiteness value L1. The larger the whiteness value L1, the better the pigment barrier effect.

[0089] In summary, the oral care composition of the present application has an appropriate content of zinc glycinate and a phosphate chelating agent, can provide a good effect of removing bad breath and blocking stains, and has good formula stability and high transparency.

[0090] The above contents are further detailed descriptions of the present application in combination with specific implementation methods, and it cannot be determined that the specific implementation of the present application is limited to these descriptions. For ordinary technicians in the technical field to which the present application belongs, several simple deductions or substitutions can be made without departing from the concept of the present application.

Claims

1. An oral care composition, characterized in that The invention comprises zinc glycinate and a phosphate chelating agent. In the oral care composition, the mass percentage of the zinc glycinate is 0.05% to 1%, the mass percentage of the phosphate chelating agent is 0.1% to 5%, and the mass ratio of the phosphate chelating agent to the zinc glycinate is greater than or equal to 2:

1.

2. The oral care composition according to claim 1, characterized in that The mass percentage of the zinc glycinate is 0.1% to 0.5%, and the mass percentage of the phosphate chelating agent is 0.5% to 3%.

3. The oral care composition according to claim 1, characterized in that The phosphate chelating agent includes at least one of polyphosphate and phytate, and the polyphosphate includes at least one of pyrophosphate, tripolyphosphate, tetrapolyphosphate, hexametaphosphate and polyphosphate.

4. The oral care composition according to claim 3, characterized in that The pyrophosphate includes at least one of tetrasodium pyrophosphate, sodium pyrophosphate, and tetrapotassium pyrophosphate; the tripolyphosphate includes at least one of pentasodium tripolyphosphate and pentapotassium tripolyphosphate; the tetrapolyphosphate includes at least one of sodium tetrapolyphosphate and potassium tetrapolyphosphate; the polyphosphate includes at least one of sodium polyphosphate and potassium polyphosphate; the hexametaphosphate includes at least one of sodium hexametaphosphate and potassium hexametaphosphate; the phytate includes at least one of sodium phytate and potassium phytate; Preferably, the phosphate chelating agent includes at least one of tetrasodium pyrophosphate, tetrapotassium pyrophosphate, pentasodium tripolyphosphate, sodium hexametaphosphate and sodium phytate.

5. The oral care composition according to claim 1, characterized in that The oral care composition includes at least one of a mouthwash, a toothpaste and a mouth spray.

6. The oral care composition according to claim 5, characterized in that The abrasive of the toothpaste is hydrated silica.

7. The oral care composition according to claim 6, characterized in that The refractive index of the hydrated silica is 1.437 to 1.464; Preferably, the refractive index of the hydrated silica is 1.449-1.

456.

8. The oral care composition according to claim 6 or 7, characterized in that The toothpaste further comprises at least one of the following: a thickener, a humectant, a foaming agent, a preservative, a fragrance, a sweetener, and a cooling agent; The thickener comprises at least one of the following: thickening hydrated silica, high-transparency xanthan gum, high-transparency carrageenan, and cellulose gum; The moisturizer includes at least one of the following: sorbitol, glycerin, propylene glycol, PEG-8.

9. The oral care composition according to claim 8, characterized in that The toothpaste comprises, by weight: 5 to 30 parts of the hydrated silica, 2 to 10 parts of the thickener, 5 to 70 parts of the moisturizer, 1 to 3 parts of the foaming agent, 0.05 to 0.5 parts of the zinc glycinate, 0.5 to 5 parts of the phosphate chelating agent, and 6 to 20 parts of water.

10. A method for preparing the oral care composition according to any one of claims 1 to 9, characterized in that: include: At 50°C to 60°C, zinc glycinate and a phosphate chelating agent are added into water and stirred; The remaining components are added and stirred to obtain the oral care composition.

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