Preparation system of carrier-free 177Lu solution

Abstract

This application discloses a carrier-free method. 177 A system for preparing Lu solution relates to the field of medical radioisotope separation technology, and is used to separate Lu-containing... 177 Lu and other lanthanides 176 Yb target dissolution solution, to obtain 177 Lu solution. The feeding module in this application has its feeding end connected to the inlet of the first separation column and the inlet of the second separation column via a first reversing valve. The inlet of the transfer container is connected to the outlet of the first separation column, and the outlet of the transfer container is connected to the inlet of the second separation column. In the first state, the feeding end of the feeding module is connected to the inlet of the first separation column, including... 177 Lu feed solution, eluent, and desorption solution sequentially enter the first separation column to separate and obtain Lu containing 177 Lu intermediate liquid, and contains 177 Lu intermediate liquid enters the transfer container. In the second state, the feed end of the feed module is connected to the inlet of the second separation column, containing... 177 Lu intermediate, eluent, and desorption solution sequentially enter the second separation column to separate and obtain carrier-free products. 177 Lu solution. This application is for the preparation of carrier-free solutions. 177 Lu solution.

Description

Technical Field

[0001] This application relates to the field of medical radioisotope separation technology, and in particular to a carrier-free method. 177 A system for preparing Lu solution. Background Technology

[0002] Due to the lack of carrier 177 Lu can be used to prepare targeted drugs such as peptides and monoclonal antibodies, therefore it is carrier-free. 177 The preparation of Lu is therefore of particular importance.

[0003] In related technologies, it is generally done inside the reactor. 176 The Yb target was irradiated, and the irradiated target was then... 176 The Yb target is dissolved in acid and then separated to obtain... 177 Lu. Due to the target nuclide 177 Lu and matrix nuclides 176 Yb are all lanthanide elements, with very similar chemical properties, and are separated during... 176 Yb amount is much greater than 177 Lu quantity, 176 Yb and 177 The Lu molar ratio is typically greater than 2000, therefore from a constant... 176 Yb separation to obtain 177 Lu is extremely challenging. Summary of the Invention

[0004] To address the aforementioned technical problems, this application provides a carrier-free... 177 A system for preparing Lu solution for separating Lu-containing compounds. 177 Lu and other lanthanides 176 Yb target dissolution solution, to obtain 177 Lu solution.

[0005] This application is achieved through the following technical solution.

[0006] This application provides a carrier-free... 177 A system for preparing Lu solution includes a feeding module, a first reversing valve, a first separation column, a transfer container, and a second separation column. The feeding module is used to provide a solution containing Lu. 177 The feed module contains raw material liquid, eluent, and desorption liquid; the feed end of the feeding module is connected to the inlet of the first separation column and the inlet of the second separation column via a first directional valve; the inlet of the transfer container is connected to the outlet of the first separation column, and the outlet of the transfer container is connected to the inlet of the second separation column. When the first directional valve is in the first state, the feed end of the feeding module is connected to the inlet of the first separation column, containing... 177 Lu feed solution, eluent, and desorption solution sequentially enter the first separation column to separate and obtain Lu containing 177Lu intermediate liquid, and contains 177 Lu intermediate liquid enters the transfer container. With the first reversing valve in the second state, the feed end of the feed module is connected to the inlet of the second separation column, containing... 177 Lu intermediate, eluent, and desorption solution sequentially enter the second separation column to separate and obtain carrier-free products. 177 Lu solution.

[0007] In the technical solution of this application embodiment, the feeding end of the feeding module is connected to the inlet of the first separation column and the second separation column through the first reversing valve, and the outlet of the first separation column and the inlet of the second separation column are connected through the transfer container.

[0008] In the preparation of carrier-free 177 When processing Lu solution, the first directional valve is first positioned in the first state, allowing the feeding module to connect to the first separation column and disconnect from the second separation column via the first directional valve. At this point, the solution containing Lu... 177 The Lu feed solution enters the first separation column, thereby allowing the first separation column to separate the contents of the feed solution. 177 Lu feed solution contains 177 Metal elements, including Lu, are adsorbed, and then the eluent enters the first separation column to remove non-lanthanide impurities from the first separation column, while retaining... 177 Lu, then the desorption solution is introduced into the first separation column to separate the contents of the first separation column. 177 Lu and 176 Yb is desorbed at different time periods to obtain a concentration of... 177 Lu intermediate liquid, and make it contain 177 Lu intermediate liquid enters the transfer container.

[0009] Next, the first directional valve is switched to the second state. At this time, the feeding end of the feeding module is connected to the inlet of the second separation column through the first directional valve, and at the same time, the material in the transfer container is... 177 Lu intermediate liquid enters the second separation column, thereby allowing the second separation column to separate the contents of Lu intermediate liquid. 177 Lu intermediate liquid contains 177 Metal elements, including Lu, are adsorbed, allowing the eluent to enter the second separation column, where it removes impurities from the column and retains... 177 Lu, then using the desorption liquid, the residue on the second separation column... 177 Lu desorption to obtain carrier-free [product / process]. 177 Lu solution, thereby passing through a first separation column and a second separation column from the solution containing... 177 Carrier-free samples were obtained from Lu feedstock. 177 Lu solution.

[0010] In this application, the cooperation of a feeding module, a first separation column, a second separation column, a first reversing valve, and a transfer container is utilized to achieve the separation of materials containing [material name missing] through a single feeding source. 177 The Lu feedstock solution underwent a two-stage separation process, ultimately yielding high-purity carrier-free feedstock. 177 The Lu solution provides a simple and convenient operation with excellent separation results.

[0011] In some embodiments of this application, it also includes: a waste liquid container;

[0012] The second directional valve connects the outlet of the first separation column to the inlet of the transfer container and the waste liquid container; the first separation column also generates first waste liquid. When the second directional valve is in its third state, the outlet of the first separation column is connected to the waste liquid container, and the first waste liquid enters the waste liquid container; when the second directional valve is in its fourth state, the outlet of the first separation column is connected to the transfer container, containing... 177 Lu intermediate liquid enters the transfer container;

[0013] And / or,

[0014] The third directional valve connects the outlet of the second separation column to the container for holding the carrierless material. 177 The Lu solution collection container and waste liquid container are connected; the second separation column also produces a second waste liquid. When the third reversing valve is in the fifth state, the outlet of the second separation column is connected to the waste liquid container, and the second waste liquid enters the waste liquid container; when the third reversing valve is in the sixth state, the outlet of the second separation column is connected to the collection container, without a carrier. 177 Lu solution enters the collection container.

[0015] With the above setup, the second reversing valve can be used to separate the first waste liquid produced by the first separation column, containing... 177 Lu intermediate liquid is diverted to waste liquid container and transfer container, thereby facilitating the first waste liquid and the liquid containing... 177 The intermediate liquids of Lu are collected and treated separately. And / or, the second waste liquid and carrier-free liquid generated by the second separation column can be disposed of using a third directional valve. 177 The Lu solution is diverted to waste liquid containers and collection containers, thus facilitating the processing of the second waste liquid and carrier-free waste. 177 The collection and processing of Lu solutions are carried out separately.

[0016] In some embodiments of this application, the device further includes: a first radioactivity detector disposed between the outlet of the first separation column and the second reversing valve, for detecting the radioactivity of the solution flowing out of the outlet of the first separation column, wherein if the first radioactivity detector detects radioactivity, the second reversing valve switches to a fourth state; and / or, a second radioactivity detector disposed between the outlet of the second separation column and the third reversing valve, for detecting the radioactivity of the solution flowing out of the outlet of the second separation column, wherein if the second radioactivity detector detects radioactivity, the third reversing valve switches to a sixth state.

[0017] With the above settings, due to 177 Lu can launch γ Therefore, by setting up a first radioactive detector, when the first radioactive detector detects that the solution flowing out of the first separation column outlet is radioactive, it proves that the solution flowing out of the first separation column outlet contains radiation. 177 Lu can then switch the second directional valve to the fourth state to contain... 177 Lu intermediate solution is collected into a transfer container. The peak time of radioactivity is determined by setting a first radioactive detector, thereby determining the collection time containing Lu. 177 The time of Lu intermediate solution. And / or, by setting a second radioactivity detector, when the second radioactivity detector detects that the solution flowing out of the second separation column outlet is radioactive, it proves that the solution flowing out of the second separation column outlet at this time contains... 177 Lu can then switch the third directional valve to the sixth state to allow the carrier-free valve to... 177 The Lu solution was collected into a collection container, and the elution time of the radioactivity was determined by setting a second radioactive detector, thereby confirming that the collection was carrier-free. 177 The time for Lu solution.

[0018] In some embodiments of this application, a first conduit is connected between the outlet of the first separation column and the inlet of the second reversing valve, and the first conduit passes through the shielding channel of the first radioactive detector; and / or, a second conduit is connected between the outlet of the second separation column and the inlet of the third reversing valve, and the second conduit passes through the shielding channel of the second radioactive detector.

[0019] By setting up a first connecting pipe, the outlet of the first separation column is connected to the second reversing valve, and the first connecting pipe passes through the shielding channel of the first radioactive detector. This not only facilitates the detection setup of the first radioactive detector but also ensures the stability of the detection. And / or, by setting up a second connecting pipe, the outlet of the second separation column is connected to the second reversing valve, and the second connecting pipe passes through the shielding channel of the second radioactive detector. This not only facilitates the detection setup of the second radioactive detector but also ensures the stability of the detection.

[0020] In some embodiments of this application, a pressure applying device is further included, the outlet of which is connected to a first separating column and a second separating column via a first reversing valve. When the first reversing valve is in a first state, the outlet of the pressure applying device is connected to the inlet of the first separating column; and / or, when the first reversing valve is in a second state, the outlet of the pressure applying device is connected to the inlet of the second separating column.

[0021] With the above configuration, when the first reversing valve is in the first state, the outlet of the pressure applying device is connected to the first separating column through the first reversing valve, thus the pressure applying device can provide... 177 The flow of Lu feed solution, eluent, and desorption solution provides the driving force, thereby increasing the content of 177 The separation efficiency of the Lu intermediate liquid. And / or, with the first reversing valve in the second state, the outlet of the pressurizing device is connected to the second separation column through the first reversing valve, so that the pressurizing device can provide power for the flow of the eluent and the desorbent, thereby improving the carrier-free separation efficiency. 177 Separation efficiency of Lu solution.

[0022] In some embodiments of this application, the feeding module includes multiple containers and a fourth directional valve, the multiple containers being used to store contents... 177 Lu is the raw material liquid, eluent, and desorption liquid. The multiple inlets of the fourth directional valve are connected to multiple containers respectively, and the outlet of the fourth directional valve is connected to the inlet of the first separation column and the inlet of the second separation column through the first directional valve.

[0023] With the above setup, multiple containers are used to store contents. 177 The raw material solution, eluent, and desorption solution are contained in multiple containers connected to the first directional valve via a fourth directional valve, thus enabling the production of solutions containing... 177 The separate supply of raw material solution, rinsing solution, and desorption solution at different times improves the convenience of the system's liquid supply.

[0024] In some embodiments of this application, the feeding module further includes a liquid level detector, which is disposed in multiple containers and used to detect the liquid level in the multiple containers.

[0025] The liquid level in the container is detected by a level detector to facilitate the monitoring of the contents of the container. 177 The levels of Lu raw material solution, eluent, and desorption solution are monitored to ensure sufficient liquid levels in the container and to guarantee the normal and stable preparation process.

[0026] In some embodiments of this application, the preparation system further includes a column oven, with a first separation column and a second separation column disposed inside the column oven.

[0027] By setting up column temperature chambers, the first and second separation columns are ensured to be heated to the set temperature during the separation process, thereby improving...177 The separation effect of Lu.

[0028] In some embodiments of this application, the first separation column is filled with cation exchange resin; the desorption solution includes an α-hydroxyisobutyric acid solution, which enters the first separation column when the first reversing valve is in the first state.

[0029] With the above setup, the α-hydroxyisobutyric acid solution can better target the nuclide. 177 Lu and matrix elements 176 Yb separation.

[0030] In some embodiments of this application, the desorption solution further includes: hydrochloric acid of different concentrations, which enters the second separation column when the first reversing valve is in the second state; the second separation column is filled with a phosphoric acid-containing extraction resin, which can adsorb α-hydroxyisobutyric acid solution. 177 Lu.

[0031] With the above settings, higher concentrations of hydrochloric acid can be desorbed. 177 Based on Lu, this allows α-hydroxyisobutyric acid to remain on the phosphoric acid-containing extraction resin, thus preventing α-hydroxyisobutyric acid from entering the carrier-free environment. 177 In Lu solution, to avoid later use of carrier-free solutions 177 In the production of targeted drugs, α-hydroxyisobutyric acid competes with the drug for labeling to ensure... 177 Normal production of Lu drugs. Attached Figure Description

[0032] Various other advantages and benefits will become apparent to those skilled in the art upon reading the detailed description of the preferred embodiments below. The accompanying drawings are for illustrative purposes only and are not intended to limit the scope of this application. Furthermore, the same reference numerals denote the same parts throughout the drawings. In the drawings:

[0033] Figure 1 Carrier-free methods provided for some embodiments of this application 177 A schematic diagram of the external structure of a Lu solution preparation system;

[0034] Figure 2 Carrier-free methods provided for some embodiments of this application 177 Another schematic diagram of the external structure of the Lu solution preparation system;

[0035] Figure 3 Carrier-free methods provided for some embodiments of this application 177 Another schematic diagram of the external structure of the Lu solution preparation system;

[0036] Figure 4 Carrier-free methods provided for some embodiments of this application 177 Another schematic diagram of the external structure of the Lu solution preparation system.

[0037] Explanation of reference numerals in the attached figures

[0038] 01-No carrier 177 Lu solution preparation system; 1-feeding module; 11-container; 12-fourth directional valve; 13-level detector; 2-first directional valve; 3-first separation column; 4-transfer container; 5-second separation column; 6-waste container; 7-second directional valve; 8-third directional valve; 9-collection container; 10-first radioactive detector; 101-second radioactive detector; 102-first connecting pipe; 103-second connecting pipe; 104-pressurization device; 105-column oven;

[0039] a-Liquid supply line; a1-First pump body; a2-First check valve; b-First branch pipe; b1-Second check valve; c-Second branch pipe; c1-Third check valve; d-First connecting pipe; e-Second connecting pipe; e1-Second pump body; e2-Fourth check valve; f-Third connecting pipe; g-Fourth connecting pipe; h-Fifth connecting pipe; i-Collection container; j-Sixth connecting pipe; k-Third pump body; l-Seventh connecting pipe. Detailed Implementation

[0040] The embodiments of the technical solution of this application will now be described in detail with reference to the accompanying drawings. These embodiments are only used to more clearly illustrate the technical solution of this application and are therefore merely examples, and should not be used to limit the scope of protection of this application.

[0041] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains; the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the application; the terms “comprising” and “having”, and any variations thereof, in the specification, claims, and foregoing description of the drawings are intended to cover non-exclusive inclusion.

[0042] In the description of the embodiments of this application, technical terms such as "first," "second," and "third" are used only to distinguish different objects and should not be construed as indicating or implying relative importance or implicitly specifying the number, specific order, or primary and secondary relationship of the indicated technical features. In the description of the embodiments of this application, "multiple" means two or more, unless otherwise explicitly defined.

[0043] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0044] In the description of the embodiments in this application, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, and B existing alone. Additionally, the character " / " in this document generally indicates that the preceding and following related objects are in an "or" relationship.

[0045] In the description of the embodiments of this application, the technical terms "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "circumferential", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of this application and simplifying the description, and do not indicate or imply that the system or component referred to must have a specific orientation, be constructed, operated or used in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this application.

[0046] In the description of the embodiments of this application, unless otherwise expressly specified and limited, technical terms such as "installation," "connection," "joining," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of this application according to the specific circumstances.

[0047] In the description of the embodiments of this application, unless otherwise expressly specified and limited, the technical term "contact" should be interpreted broadly, and can be direct contact, contact through an intermediate medium layer, contact between two contacting parties with substantially no interaction force, or contact between two contacting parties with interaction force.

[0048] The following is a detailed description of this application.

[0049] 177 Lu (lutetium-177) has a long half-life and emits β particles and γ rays. The β particles have moderate energy and good coordination chemistry, so they can be used for the preparation and application of targeted drugs such as peptides and monoclonal antibodies.

[0050] 177 Lu is divided into carriers 177 Lu and carrier-free 177 Lu. In the presence of a carrier 177 Lu contains a large amount of non-radioactive cold Lu, making it unsuitable for the preparation of targeted drugs such as peptides and monoclonal antibodies, and lacking a carrier. 177 Lu contains no non-radioactive Lu and has a high specific activity, which can yield high-quality drugs when used in the preparation of targeted drugs.

[0051] In related technologies, carrier-free 177 The preparation of Lu generally involves the following steps: first, the process of preparing Lu within a reactor... 176 Irradiation of Yb (ytterbium-176) targets to obtain [the desired product]. 177 Lu and other lanthanides 176 Yb target, using acid to... 176 After the Yb target is dissolved to obtain a solution, the solution is then separated to finally obtain... 177 Lu solution.

[0052] However, due to the target nuclide 177 Lu and matrix nuclides 176 Yb has very similar chemical properties, therefore, in the separation to obtain 177 The operation is quite difficult when using Lu solution.

[0053] Based on this, such as Figure 1 As shown, this application provides a carrier-free... 177 The Lu solution preparation system 01 includes a feeding module 1, a first reversing valve 2, a first separation column 3, a transfer container 4, and a second separation column 5. The feeding module 1 is used to supply Lu solution containing... 177 The feed consists of raw material liquid, eluent, and desorption liquid. The feed end of the feeding module 1 is connected to the inlet of the first separation column 3 and the inlet of the second separation column 5 via the first reversing valve 2. The inlet of the transfer container 4 is connected to the outlet of the first separation column 3, and the outlet of the transfer container 4 is connected to the inlet of the second separation column 5.

[0054] With the first directional valve 2 in the first state, the feeding end of the feeding module 1 is connected to the inlet of the first separating column 3, including... 177 Lu feed solution, eluent, and desorption solution sequentially enter the first separation column 3 to separate and obtain Lu containing 177 Lu intermediate liquid, and contains 177 Lu intermediate liquid enters the transfer container 4. With the first reversing valve 2 in the second state, the feed end of the feed module 1 is connected to the inlet of the second separation column 5, containing... 177 Lu intermediate, eluent, and desorption solution sequentially enter the second separation column 5 to separate and obtain carrier-free products.177 Lu solution.

[0055] It should be explained that the connection between the feeding end of the feeding module 1 and the inlet of the first separation column 3 and the inlet of the second separation column 5 via the first reversing valve 2 means that the first inlet of the first reversing valve 2 is connected to the feeding end of the feeding module 1, the first outlet of the first reversing valve 2 is connected to the inlet of the first separation column 3, and the second outlet of the first reversing valve 2 is connected to the inlet of the second separation column 5.

[0056] When the first directional valve 2 is switched to the first state, the passage connecting its first inlet and first outlet is opened, thereby connecting the feeding end of the feeding module 1 with the inlet of the first separating column 3. Similarly, when the first directional valve 2 is switched to the second state, the passage connecting its first inlet and second outlet is opened, thereby connecting the feeding end of the feeding module 1 with the inlet of the second separating column 5.

[0057] Both the first separation column 3 and the second separation column 5 are chromatographic columns, and both are filled with resin material. Thus, in the presence of... 177 When the Lu feed liquid passes through the first separation column 3, the resin material can adsorb the contents of the feed liquid. 177 Lu feedstock solution 177 Lu and 176 Yb, in containing 177 When the intermediate liquid of Lu passes through the second separation column 5, the resin material can adsorb the contents of Lu. 177 Lu intermediate liquid 177 Lu and 176 Yb, so that when the eluent passes through the first separation column 3 and the second separation column 5, it can achieve 177 Lu and 176 Separation of Yb and other non-lanthanide impurities. Then, the first separation column 3 is eluted with desorption buffer to remove... 177 Lu and 176 Yb separated, resulting in 177 The intermediate solution was then eluted with the desorption buffer onto the second separation column 5 to remove a small amount of [unspecified substance]. 176 Yb, ultimately yielding a carrier-free solution. 177 Lu solution.

[0058] Based on this, before performing the separation operation, the acidic solution and the aqueous solution can be passed through the first separation column 3 and the second separation column 5 so that the resin materials in the first separation column 3 and the second separation column 5 can reach pre-equilibrium.

[0059] The first separation column 3 can have a height of 500 mm and an inner diameter of 10 mm. The second separation column 5 can have a height of 350 mm and an inner diameter of 10 mm. Because the second separation column 5 separates substances containing...177 Lu intermediate solution 176 The Yb content, compared to that separated by the first separation column 3, is... 177 Lu feed solution 176 The Yb content needs to be low, so the size of the second separation column 5 can be slightly smaller than that of the first separation column 3. This can ensure the required concentration for separation and purification while reducing the procurement costs of the first separation column 3 and the second separation column 5.

[0060] In addition, including 177 Lu feedstock solution can be used for reactor operations. 176 The Yb target obtained after irradiation contains 176 Yb、 177 The eluent is a solution containing Lu and other impurity elements. The eluent may include water, acidic solutions, such as HCl (hydrochloric acid). The desorption solution in the first separation column 3 may be an organic acid solution capable of complexing with rare earth elements, such as α-HIBA (α-hydroxyisobutyric acid) or citric acid. The desorption solution in the second separation column 5 is a gradient concentration of HCl.

[0061] In some examples, the feeding module 1 may include multiple containers 11, each of which is used to hold a substance containing... 177 Lu contains raw material solution, eluent, and desorption solution. Container 11 can be a standard glass bottle. Multiple containers 11 can be placed on a feed rack.

[0062] In some examples, transit container 4 can be used to collect [contents]. 177 It is a special container for Lu liquid, or it can be a regular glass bottle.

[0063] With the above configuration, the feeding end of the feeding module 1 is connected to the inlet of the first separating column 3 and the second separating column 5 through the first reversing valve 2, and the outlet of the first separating column 3 and the inlet of the second separating column 5 are connected through the transfer container 4.

[0064] In the preparation of carrier-free 177 When using Lu solution, the first reversing valve 2 is first set to the first state, so that the feeding module 1 is connected to the first separation column 3 through the first reversing valve 2 and isolated from the second separation column 5. At this time, the solution containing Lu is... 177 Lu feed liquid enters the first separation column 3 (upper column), thereby allowing the first separation column 3 to separate the feed liquid containing Lu feed liquid. 177 Lu feed liquid 176 Yb、 177 Lu adsorption occurs, and then the eluent enters the first separation column 3 to remove impurity elements from the first separation column 3, while retaining... 176 Yb、 177 Lu, then the desorption solution is introduced into the first separation column 3 to separate the contents of the first separation column 3.177 Lu and 176 Yb desorption, due to 177 Lu、 176 The complexes formed by Yb and the complexing agent have different retention times on the resin in the first separation column 3, therefore 177 Lu and 176 Yb can be eluted sequentially to collect the contents. 177 The components of Lu, i.e., containing 177 Lu intermediate liquid, and make it contain 177 Lu intermediate liquid enters transfer container 4.

[0065] Next, the first reversing valve 2 is switched to the second state. At this time, the feeding end of the feeding module 1 is connected to the inlet of the second separation column 5 through the first reversing valve 2, and at the same time, the material in the transfer container 4 is... 177 Lu intermediate liquid enters the second separation column 5, thereby allowing the second separation column 5 to separate the contents of Lu intermediate liquid. 177 Lu intermediate liquid contains 177 Lu and a small amount 176 Yb adsorption occurs, followed by the introduction of a low-concentration HCl eluent into the second separation column 5, which removes impurities from the second separation column 5 and retains... 177 Lu, then using a higher concentration of HCl desorption solution, the material on the second separation column 5 was further separated. 177 Lu desorption to obtain carrier-free [product / process]. 177 Lu solution, thereby passing through the first separation column 3 and the second separation column 5 from the solution containing... 177 Carrier-free samples were obtained by separation and purification from Lu feed solution. 177 Lu solution.

[0066] In this application, the feeding module 1, the first separation column 3, the second separation column 5, the first reversing valve 2, and the transfer container 4 are used in conjunction to achieve the separation of materials containing [material name missing] through a single feeding source. 177 The Lu feedstock solution underwent two-stage separation, ultimately yielding a high-purity carrier-free solution. 177 The Lu solution provides a simple and convenient operation with excellent separation results.

[0067] In some embodiments, such as Figure 1 As shown, a liquid supply pipe a is connected between the feeding end of the feeding module 1 and the first inlet of the first reversing valve 2; a first branch pipe b is connected between the first outlet of the first reversing valve 2 and the inlet of the first separating column 3; a second branch pipe c is connected between the second outlet of the first reversing valve 2 and the inlet of the second separating column 5; a first connecting pipe d is connected between the inlet of the transfer container 4 and the outlet of the first separating column 3; and a second connecting pipe e is connected between the outlet of the transfer container 4 and the inlet of the second separating column 5. This pipe connection facilitates the connection of the carrier-free... 177 Overall layout of Lu solution preparation system 01.

[0068] The first directional valve 2 can be a valve for long-term stable use or a valve that can be replaced once. When the first directional valve 2 is a valve for long-term stable use, the material of the first directional valve 2 may include poly(ether-ether-ketone); PEEK. When the first directional valve 2 is a valve that can be replaced once, the material of the first directional valve 2 may include polyvinyl chloride (PVC).

[0069] In some examples, such as Figure 1 As shown, a first pump body a1 is installed on the liquid supply pipeline a. The first pump body a1 provides power for the feeding module 1, so that the liquid containing... 177 Lu raw material liquid, rinsing liquid and desorption liquid can flow in the supply pipeline a, the first branch pipe b and the second branch pipe c.

[0070] In some examples, such as Figure 1 As shown, a second pump body e1 is provided on the second connecting pipe e, and the second pump body e1 contains... 177 Lu intermediate liquid flows from the outlet of the first separation column 3 to the inlet of the second separation column 5 to provide power.

[0071] The first pump body a1 and the second pump body e1 are peristaltic pumps. Both pump body a1 and pump body e1 have their flow rate and volume controlled by stepper motors (e.g., adjustable between 0 and 50 ml / min) to ensure stable preparation. Furthermore, the peristaltic pump avoids contact between the pump core and the liquid (including...). 177 Lu raw material solution, eluent, desorption solution or containing 177 To prevent damage to the pump core, the intermediate liquid (Lu) is in contact with the pump. Furthermore, the materials for the supply line a and the second connecting pipe e are both high-polymer materials (BPT) or fluororubber, giving the supply line a and the second connecting pipe e radiation-resistant and acid / alkali-resistant properties, and facilitating the compression of the first pump body a1 and the second pump body e1.

[0072] Furthermore, the materials of the first branch pipe b, the second branch pipe c, the first connecting pipe d, and the second connecting pipe e include polytetrafluoroethylene (PTFE), and it is a transparent type of PTFE. Thus, the first branch pipe b, the second branch pipe c, the first connecting pipe d, and the second connecting pipe e possess excellent radiation resistance and acid and alkali resistance.

[0073] In addition, pipe fittings are provided at the ends of the liquid supply lines a, the first branch line b, the second branch line c, the first connecting line d, and the second connecting line e to facilitate connection. The pipe fittings may be made of PEEK, a material known for its high structural strength and excellent sealing performance.

[0074] In some examples, such as Figure 1 As shown, a first check valve a2 is installed on the liquid supply line a to prevent liquid from entering the liquid supply line a. 177 Lu feed liquid, eluent, and desorption liquid are refluxed. A second one-way valve b1 is installed on the first branch pipe b to prevent backflow of liquid entering the first separation column 3. A third one-way valve c1 is installed on the second branch pipe c to prevent backflow of liquid entering the second separation column 5. A fourth one-way valve e2 is installed on the second connecting pipe e to prevent backflow of liquid entering the second separation column 5.

[0075] In some embodiments, no carrier 177 The Lu solution preparation system 01 also includes a support module, which includes a shell and a support frame inside it. The first separation column 3, the second separation column 5, and the transfer container 4 are mounted on the support frame and located inside the shell. The support frame provides support for the first separation column 3, the second separation column 5, and the transfer container 4, while the shell provides protection.

[0076] The outer shell is made of multiple stainless steel plates with a brushed surface. Each steel plate is connected to the bracket by fasteners such as screws, so that each steel plate can be disassembled and installed separately from the bracket.

[0077] Including 177 After the Lu feed solution, eluent, and desorption solution pass sequentially through the first separation column 3, not only are products containing... 177 Lu intermediate liquid, and also generated waste liquids such as permeate and rinsing waste liquid, in the presence of ... 177 After passing through the second separation column 5, the intermediate liquid, eluent, and desorption liquid of Lu not only produce carrier-free products, but also... 177 The solution contains Lu, and also generates permeate and rinsing waste liquid, so it is necessary to achieve separation of waste liquid from Lu solution. 177 Lu intermediate liquid, carrier-free 177 The Lu solution was collected separately at different time points.

[0078] Based on this, in the first possible implementation, such as Figure 2 As shown, without carrier 177 The Lu solution preparation system 01 also includes a waste liquid container 6, a second reversing valve 7, and a third reversing valve 8. The outlet of the first separation column 3 is connected to the inlet of the transfer container 4 and the waste liquid container 6 through the second reversing valve 7; the first separation column 3 also generates first waste liquid. When the second reversing valve 7 is in the third state, the outlet of the first separation column 3 is connected to the waste liquid container 6, and the first waste liquid enters the waste liquid container 6. When the second reversing valve 7 is in the fourth state, the outlet of the first separation column 3 is connected to the transfer container 4, containing... 177 Lu intermediate liquid enters transfer container 4.

[0079] The outlet of the second separation column 5 is connected to the container for carrier-free material via the third reversing valve 8. 177 The Lu solution collection container 9 and waste liquid container 6 are connected; the second separation column 5 also generates a second waste liquid. When the third reversing valve 8 is in the fifth state, the outlet of the second separation column 5 is connected to the waste liquid container 6, and the second waste liquid enters the waste liquid container 6. When the third reversing valve 8 is in the sixth state, the outlet of the second separation column 5 is connected to the collection container 9, without a carrier. 177 The Lu solution enters the collection container 9.

[0080] It is understandable that the type of the second directional valve 7 may be the same as or different from the type of the first directional valve 2, and the type of the third directional valve 8 may be the same as or different from the type of the first directional valve 2.

[0081] It needs to be explained that the connection between the outlet of the first separation column 3 and the inlet of the transfer container 4 and the waste liquid container 6 via the second reversing valve 7 means that the inlet of the second reversing valve 7 is connected to the outlet of the first separation column 3, the first outlet of the second reversing valve 7 is connected to the inlet of the transfer container 4, and the second outlet of the second reversing valve 7 is connected to the waste liquid container 6.

[0082] The outlet of the second separation column 5 is connected to the container for carrier-free material via the third reversing valve 8. 177 The connection between the Lu solution collection container 9 and the waste liquid container 6 means that the inlet of the third reversing valve 8 is connected to the outlet of the second separation column 5, the first outlet of the third reversing valve 8 is connected to the collection container 9, and the second outlet of the third reversing valve 8 is connected to the waste liquid container 6.

[0083] In some examples, such as Figure 2 As shown, a first connecting pipe 102 connects the outlet of the first separating column 3 to the inlet of the second reversing valve 7. A first connecting pipe d connects the inlet of the transfer container 4 to the first outlet of the second reversing valve 7. A third connecting pipe f connects the second outlet of the second reversing valve 7 to the waste liquid container 6. This facilitates the separation of the first waste liquid and the waste liquid containing... 177 The flow of Lu intermediate liquid also facilitates spatial layout.

[0084] In some examples, such as Figure 2 As shown, a second connecting pipe 103 connects the outlet of the second separation column 5 to the inlet of the third reversing valve 8; a fourth connecting pipe g connects the first outlet of the third reversing valve 8 to the collection container 9; and a fifth connecting pipe h connects the second outlet of the third reversing valve 8 to the waste liquid container 6. This facilitates the separation of the second waste liquid and the carrier-free waste liquid. 177 The flow of Lu solution also facilitates spatial layout.

[0085] In some examples, the waste liquid container 6 can be a 10-liter tank structure, which facilitates communication between the waste liquid container 6 and the outlet of the first separation column 3 and the outlet of the second separation column 5. Additionally, when containing... 177 Lu feedstock solution is 176 When the Yb target is dissolved in the reactor after being irradiated, the first waste liquid produced by the first separation column 3 and the second waste liquid produced by the second separation column 5 contain fewer types of radioactive impurities, so they can be collected using a waste liquid container 6.

[0086] With the above setup, the second reversing valve 7 can be used to separate the first waste liquid generated by the first separation column 3, containing... 177 Lu intermediate liquid is diverted to waste liquid container 6 and transfer container 4, thereby facilitating the first waste liquid and the liquid containing... 177 The intermediate liquids of Lu are collected and treated separately. Similarly, the second waste liquid and carrier-free liquid generated by the second separation column 5 can be collected and treated separately using the third reversing valve 8. 177 The Lu solution is diverted to waste liquid container 6 and collection container 9, thereby facilitating the processing of the second waste liquid and carrier-free waste liquid. 177 The collection and processing of Lu solutions are carried out separately.

[0087] In the second possible implementation, such as Figure 2 As shown, without carrier 177 The Lu solution preparation system 01 also includes a waste liquid container 6 and a second reversing valve 7. The outlet of the first separation column 3 is connected to the inlet of the transfer container 4 and the waste liquid container 6 through the second reversing valve 7; the first separation column 3 also generates first waste liquid. When the second reversing valve 7 is in the third state, the outlet of the first separation column 3 is connected to the waste liquid container 6, and the first waste liquid enters the waste liquid container 6; when the second reversing valve 7 is in the fourth state, the outlet of the first separation column 3 is connected to the transfer container 4, containing... 177 Lu intermediate liquid enters transfer container 4.

[0088] With the above setup, the second reversing valve 7 can be used to separate the first waste liquid generated by the first separation column 3, containing... 177 Lu intermediate liquid is diverted to waste liquid container 6 and transfer container 4, thereby facilitating the first waste liquid and the liquid containing... 177 The Lu intermediate liquid is collected and processed separately.

[0089] In the third possible implementation, such as Figure 2 As shown, without carrier 177 The Lu solution preparation system 01 also includes a waste liquid container 6 and a third reversing valve 8. The outlet of the second separation column 5 is connected to a container for holding carrier-free liquid via the third reversing valve 8. 177The Lu solution collection container 9 and waste liquid container 6 are connected; the second separation column 5 also produces a second waste liquid. When the third reversing valve 8 is in the fifth state, the outlet of the second separation column 5 is connected to the waste liquid container 6, and the second waste liquid enters the waste liquid container 6; when the third reversing valve 8 is in the sixth state, the outlet of the second separation column 5 is connected to the collection container 9, without a carrier. 177 The Lu solution enters the collection container 9.

[0090] With the above setup, the third reversing valve 8 can be used to separate the second waste liquid and carrier-free liquid generated by the second separation column 5. 177 The Lu solution is diverted to waste liquid container 6 and collection container 9, thereby facilitating the processing of the second waste liquid and carrier-free waste liquid. 177 The collection and processing of Lu solutions are carried out separately.

[0091] Of course, in other embodiments, a single pipeline can be used to discharge the permeate, rinsing waste liquid, and other waste liquids in stages. 177 Lu intermediate liquid. Similarly, a single pipeline can be used to discharge permeate, rinsing waste liquid, and carrier-free liquid in stages. 177 Lu solution.

[0092] During the preparation process, in order to facilitate monitoring 177 The radioactivity peak time of Lu needs to be determined by placing radioactive detectors at different locations to identify the content of Lu. 177 Lu intermediate liquid and first waste liquid, without carrier 177 The collection times for Lu solution and the second waste liquid.

[0093] Based on this, in the first possible implementation, such as Figure 2 , Figure 3 As shown, without carrier 177 The Lu solution preparation system 01 also includes a first radioactive detector 10 and a second radioactive detector 101. The first radioactive detector 10 is located between the outlet of the first separation column 3 and the second reversing valve 7, and is used to detect the radioactivity of the solution flowing out of the outlet of the first separation column 3. When the first radioactive detector 10 detects radioactivity, the second reversing valve 7 switches to a fourth state. The second radioactive detector 101 is located between the outlet of the second separation column 5 and the third reversing valve 8, and is used to detect the radioactivity of the solution flowing out of the outlet of the second separation column 5. When the second radioactive detector 101 detects radioactivity, the third reversing valve 8 switches to a sixth state.

[0094] It is understandable that the first radioactive detector 10 and the second radioactive detector 101 need to be radiation-resistant, have a long lifespan, and a wide measurement range. This makes them better suited for high-radiation environments.

[0095] Among them, radioactivity mainly comes from177 Lu produces 113 keV and 208 keV gamma rays.

[0096] In some examples, if the first radioactive detector 10 does not detect radioactivity, the second reversing valve 7 switches to the third state, at which point the first waste liquid is discharged into the waste liquid container 6.

[0097] In some examples, if the second radioactive detector 101 does not detect radioactivity, the third reversing valve 8 switches to the fifth state, at which point the second waste liquid is discharged into the waste liquid container 6.

[0098] With the above settings, due to 177 Lu can launch γ Therefore, by setting up a first radioactive detector 10, when the first radioactive detector 10 detects that the solution flowing out of the outlet of the first separation column 3 is radioactive, it proves that the solution flowing out of the outlet of the first separation column 3 contains radiation. 177 Lu can then switch the second directional valve 7 to the fourth state to contain... 177 Lu intermediate liquid is collected into transfer container 4. If the first radioactivity detector 10 does not detect radioactivity, the second reversing valve 7 is switched to the third state, at which point the first waste liquid is discharged into waste liquid container 6. The first radioactivity detector 10 is used to determine... 177 The peak emission time of the gamma rays produced by Lu was used to determine the collection of gamma rays containing Lu. 177 The time of Lu intermediate liquid, thereby achieving the content 177 Lu intermediate liquid and first waste liquid are collected in stages.

[0099] By setting up a second radioactive detector 101, when the second radioactive detector 101 detects that the solution flowing out of the outlet of the second separation column 5 is radioactive, it is proven that the solution flowing out of the outlet of the second separation column 5 contains radioactivity. 177 Lu can then switch the third directional valve 8 to the sixth state to control the carrierless valve. 177 Lu solution is collected into collection container 9. If the second radioactivity detector 101 does not detect radioactivity, the third reversing valve 8 is switched to the fifth state, at which point the second waste liquid is discharged into waste liquid container 6. The second radioactivity detector 101 is used to determine... 177 The peak emission time of the gamma rays produced by Lu was used to determine the collection method for carrier-free samples. 177 The time of Lu solution, thereby achieving carrier-free [process]. 177 Lu solution and second waste liquid are collected in stages.

[0100] In the second possible implementation, such as Figure 3 As shown, without carrier 177The Lu solution preparation system 01 also includes a first radioactive detector 10, which is located between the outlet of the first separation column 3 and the second reversing valve 7. The first radioactive detector 10 is used to detect the radioactivity of the solution flowing out of the outlet of the first separation column 3. When the first radioactive detector 10 detects radioactivity, the second reversing valve 7 switches to the fourth state.

[0101] With the above settings, due to 177 Lu can launch γ Rays, and γ Since rays are radioactive, by setting up a first radioactive detector 10, when the first radioactive detector 10 detects that the solution flowing out of the outlet of the first separation column 3 is radioactive, it proves that the solution flowing out of the outlet of the first separation column 3 contains... 177 Lu can then switch the second directional valve 7 to the fourth state to contain... 177 Lu intermediate liquid is collected into transfer container 4. If the first radioactivity detector 10 does not detect radioactivity, the second reversing valve 7 is switched to the third state, at which point the first waste liquid is discharged into waste liquid container 6. The first radioactivity detector 10 is used to determine... 177 The peak emission time of the gamma rays produced by Lu was used to determine the collection of gamma rays containing Lu. 177 The time of Lu intermediate liquid, thereby achieving the content 177 Lu intermediate liquid and first waste liquid are collected in stages.

[0102] In the third possible implementation, such as Figure 3 As shown, without carrier 177 The Lu solution preparation system 01 also includes a second radioactive detector 101, which is located between the outlet of the second separation column 5 and the third reversing valve 8. The second radioactive detector 101 is used to detect the radioactivity of the solution flowing out of the outlet of the second separation column 5. When the second radioactive detector 101 detects radioactivity, the third reversing valve 8 switches to the sixth state.

[0103] By setting up a second radioactive detector 101, when the second radioactive detector 101 detects that the solution flowing out of the outlet of the second separation column 5 is radioactive, it is proven that the solution flowing out of the outlet of the second separation column 5 contains radioactivity. 177 Lu can then switch the third directional valve 8 to the sixth state to control the carrierless valve. 177 Lu solution is collected into collection container 9. If the second radioactivity detector 101 does not detect radioactivity, the third reversing valve 8 is switched to the fifth state, at which point the second waste liquid is discharged into waste liquid container 6. The second radioactivity detector 101 is used to determine... 177 The peak emission time of the gamma rays produced by Lu was used to determine the collection method for carrier-free samples. 177The time of Lu solution, thereby achieving carrier-free [process]. 177 Lu solution and second waste liquid are collected in stages.

[0104] Based on this, in some embodiments, such as Figure 3 As shown, a first conductive pipe 102 connects the outlet of the first separation column 3 and the inlet of the second reversing valve 7, and the first conductive pipe 102 passes through the shielding channel of the first radioactive detector 10. A second conductive pipe 103 connects the outlet of the second separation column 5 and the inlet of the third reversing valve 8, and the second conductive pipe 103 passes through the shielding channel of the second radioactive detector 101.

[0105] It is understandable that both the first conductive tube 102 and the second conductive tube 103 allow radioactive materials to pass through. This is necessary to enable the first radioactive detector 10 and the second radioactive detector 101 to detect radioactivity.

[0106] The first conductive tube 102 and the second conductive tube 103 are flexible tubes, and their materials may include Teflon.

[0107] By setting the first conductive tube 102, the first conductive tube 102 can connect the outlet of the first separation column 3 and the inlet of the second reversing valve 7, thereby realizing the flow of solution. Since the first conductive tube 102 passes through the shielding channel of the first radioactive detector 10, it can not only facilitate the detection setting of the first radioactive detector 10, but also ensure the stability of detection.

[0108] By setting a second conduit 103, the second conduit 103 can connect the outlet of the second separation column 5 with the inlet of the third reversing valve 8, thereby realizing the flow of solution. Since the second conduit 103 passes through the shielding channel of the second radioactive detector 101, it not only facilitates the detection setting of the second radioactive detector 101, but also ensures the stability of detection.

[0109] In other embodiments, such as Figure 3 As shown, a first conduit 102 connects the outlet of the first separation column 3 and the inlet of the second reversing valve 7, and the first conduit 102 passes through the shielding channel of the first radioactive detector 10.

[0110] By setting the first conductive tube 102, the first conductive tube 102 can connect the outlet of the first separation column 3 and the inlet of the second reversing valve 7, thereby realizing the flow of solution. Since the first conductive tube 102 passes through the shielding channel of the first radioactive detector 10, it can not only facilitate the detection setting of the first radioactive detector 10, but also ensure the stability of detection.

[0111] In other embodiments, such as Figure 3As shown, a second conduit 103 connects the outlet of the second separation column 5 and the inlet of the third reversing valve 8, and the second conduit 103 passes through the shielding channel of the second radioactive detector 101.

[0112] By setting a second conduit 103, the second conduit 103 can connect the outlet of the second separation column 5 with the inlet of the third reversing valve 8, thereby realizing the flow of solution. Since the second conduit 103 passes through the shielding channel of the second radioactive detector 101, it not only facilitates the detection setting of the second radioactive detector 101, but also ensures the stability of detection.

[0113] Of course, in other embodiments, the first radioactive detector 10 may be attached only to the first conductive tube 102, and the second radioactive detector 101 may be attached only to the second conductive tube 103, so as to achieve the detection of radioactivity.

[0114] Based on this, in some embodiments, such as Figure 3 As shown, without carrier 177 The Lu solution preparation system 01 also includes a product container i, the inlet of which is connected to the outlet of a collection container 9. A sixth connecting pipe j connects the inlet of product container i to the collection container 9, and a third pump body k is disposed on the sixth connecting pipe j. Thus, the third pump body k can drive the carrier-free solution in the collection container 9. 177 Solution Lu enters product container i to facilitate subsequent processing. 177 Movement of Lu solution.

[0115] Among them, product container i can be a regular glass bottle.

[0116] In some embodiments, such as Figure 3 As shown, without carrier 177 The Lu solution preparation system 01 also includes a pressure application device 104, the outlet of which is connected to a first separation column 3 and a second separation column 5 via a first reversing valve 2. When the first reversing valve 2 is in a first state, the outlet of the pressure application device 104 is connected to the inlet of the first separation column 3; and / or, when the first reversing valve 2 is in a second state, the outlet of the pressure application device 104 is connected to the inlet of the second separation column 5.

[0117] It is understandable that the connection between the outlet of the pressure device 104 and the first separation column 3 and the second separation column 5 via the first reversing valve 2 means that the outlet of the pressure device 104 is connected to the second inlet of the first reversing valve 2.

[0118] A seventh connecting pipe 1 is connected between the outlet of the pressure applying device 104 and the second inlet of the second reversing valve 7, which facilitates the connection between the pressure applying device 104 and the second reversing valve 7.

[0119] Additionally, the pressure device 104 can be an air supply pump, which can contain... 177 The flow of the raw material liquid, eluent, and desorption liquid provides pressure. A plunger pump can be used as the air supply pump. The plunger pump and the seventh connecting pipe l can be installed using either a press-fit or screw-locking method, making installation and disassembly easier.

[0120] With the above configuration, when the first reversing valve 2 is in the first state, the outlet of the pressure applying device 104 is connected to the first separating column 3 through the first reversing valve 2, thus the pressure applying device 104 can be used to apply pressure containing... 177 The flow of Lu feed solution, eluent, and desorption solution provides the driving force, thereby increasing the content of 177 The separation efficiency of the Lu intermediate liquid. And / or, when the first reversing valve 2 is in the second state, the outlet of the pressure device 104 is connected to the second separation column 5 through the first reversing valve 2, so that the pressure device 104 can provide power for the flow of the eluent and the desorbent, thereby improving the carrier-free separation efficiency. 177 Separation efficiency of Lu solution.

[0121] In some embodiments, such as Figure 4 As shown, the feeding module 1 includes multiple containers 11 and a fourth reversing valve 12. The multiple containers 11 are respectively used to store contents containing 177 Lu is the raw material liquid, the eluent, and the desorption liquid. The multiple inlets of the fourth directional valve 12 are connected to multiple containers 11 respectively, and the outlet of the fourth directional valve 12 is connected to the inlet of the first separation column 3 and the inlet of the second separation column 5 through the first directional valve 2.

[0122] It is understandable that the number of containers 11 should be based on the contents. 177 The types of Lu feed solution, eluent, and desorption solution are determined.

[0123] For example, containing 177 The Lu feed solution occupies one container 11. The eluent includes water, 0.1 mol / L hydrochloric acid, 1 mol / L NH4Cl and 0.3 mol / L hydrochloric acid, so the eluent occupies four containers 11. The desorption solution includes 0.04-0.06 mol / L α-hydroxyisobutyric acid solution and 3-6 mol / L hydrochloric acid, so the desorption solution occupies two containers 11. Therefore, a total of seven containers 11 are used.

[0124] Among them, container 11 can be a regular glass bottle, etc.

[0125] In addition, the volume of each container 11 can be 10ml, 15ml or 20ml, etc.

[0126] With the above setup, multiple containers 11 are used to store contents... 177Lu raw material solution, eluent, and desorption solution, since multiple containers 11 are connected to the first directional valve 2 through the fourth directional valve 12, can achieve the following: 177 The separate supply of raw material solution, rinsing solution, and desorption solution at different times improves the convenience of the system's liquid supply.

[0127] In some embodiments, such as Figure 4 As shown, the feeding module 1 also includes a liquid level detector 13, which is disposed in multiple containers 11 and is used to detect the liquid level in the multiple containers 11.

[0128] The liquid level detector 13 can be either a contact type or a non-contact type, depending on the specific needs.

[0129] In addition, the number of liquid level detectors 13 can be the same as the number of containers 11, with one liquid level detector 13 corresponding to one container 11, and one liquid level detector 13 detecting the liquid content in one container 11.

[0130] The liquid level in container 11 is detected by liquid level detector 13 to facilitate the monitoring of the liquid content in container 11. 177 The levels of raw material solution, eluent, and desorption solution are monitored to ensure sufficient liquid levels in container 11, thus ensuring the normal and stable preparation process.

[0131] In some embodiments, such as Figure 4 As shown, the preparation system 01 also includes a column oven 105, in which the first separation column 3 and the second separation column 5 are disposed.

[0132] The column temperature chamber 105 has a fixed column, and the first separation column 3 and the second separation column 5 can be fixed to the fixed column inside the column temperature chamber 105 by clamps.

[0133] In addition, the temperature provided by the column oven 105 for the first separation column 3 and the second separation column 5 can be between 30°C and 60°C, for example, 30°C, 40°C, 50°C or 60°C. This temperature range can maximize the separation efficiency.

[0134] By setting up the column temperature chamber 105, it not only provides installation positions for the first separation column 3 and the second separation column 5, but also provides a stable temperature for the first separation column 3 and the second separation column 5 during the separation process. When heating the first separation column 3 and the second separation column 5 to the set temperature, it can ensure the stable and rapid progress of the separation process within the first separation column 3 and the second separation column 5, and at the same time improve... 177 The separation effect of Lu.

[0135] In some embodiments, the first separation column 3 is filled with cation exchange resin; the desorption solution includes an α-hydroxyisobutyric acid solution, which enters the first separation column 3 when the first reversing valve 2 is in the first state.

[0136] The cation exchange resin can be DOWEX 50W X8.

[0137] In addition, the concentration of the α-hydroxyisobutyric acid solution can be 0.04-0.06 mol / L, for example, it can be 0.04 mol / L, 0.045 mol / L, 0.049 mol / L, 0.05 mol / L or 0.06 mol / L.

[0138] With the above setup, the α-hydroxyisobutyric acid solution can better target the nuclide. 177 Lu and matrix elements 176 Separating Yb can improve the separation effect between the two.

[0139] In some embodiments, the desorption solution further includes hydrochloric acid, which enters the second separation column 5 when the first reversing valve 2 is in the second state. The second separation column 5 is filled with a phosphate-containing extraction resin, which is capable of adsorbing α-hydroxyisobutyric acid solution. 177 Lu.

[0140] The concentration of hydrochloric acid can be 3-6 mol / L.

[0141] In addition, phosphoric acid-containing extraction resins can be P204 extraction resin, P507 extraction resin, and Ln extraction resin.

[0142] With the above settings, higher concentrations of hydrochloric acid can be desorbed. 177 Based on Lu, this allows α-hydroxyisobutyric acid to remain on the phosphoric acid-containing extraction resin, thus preventing α-hydroxyisobutyric acid from entering the carrier-free environment. 177 In Lu solution, to avoid later use of carrier-free solutions 177 In the production of targeted drugs, α-hydroxyisobutyric acid competes with the drug for labeling to ensure... 177 Normal production of Lu drugs.

[0143] In some embodiments of this application, the carrier-free method is described. 177The Lu solution preparation system 01 also includes a controller, which is electrically connected to the first pump body a1, the second pump body e1, the third pump body k, the pressure application device 104, the first check valve a2, the second check valve b1, the third check valve c1, the fourth check valve e2, the first reversing valve 2, the second reversing valve 7, the third reversing valve 8, the fourth reversing valve 12, the first radioactive detector 10, the second radioactive detector 101, and the liquid level detector 105. The controller allows for remote control of the carrier-free system. 177 The operation of the Lu solution preparation system 01 can avoid direct contact between the operator and the carrier-free solution. 177 The Lu solution preparation system is in contact with 01 to ensure the safety of the operator.

[0144] Furthermore, it also facilitates the control of substances contained in the preparation process. 177 Lu raw material solution, eluent, desorption solution, containing 177 The flow rate of liquids such as Lu intermediate liquid is monitored, and it is also convenient to use the first radioactive detector 10 and the second radioactive detector 101 to monitor the flow rate of these liquids. 177 The radioactive elution time of Lu was detected to achieve automated separation and preparation.

[0145] In addition, the above data can be displayed on a computer screen for operators to observe.

[0146] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A carrier-free 177 System for the preparation of a Lu solution, characterized by, The preparation system comprises: a feed module for providing a feed liquid containing 177 a Lu feed liquid, a elution liquid and a desorption liquid; a feed end of the feed module is connected with an inlet of the first separation column and an inlet of the second separation column through the first switching valve; an inlet of the transfer container is communicated with an outlet of the first separation column, and an outlet of the transfer container is communicated with an inlet of the second separation column; In the case that the first reversing valve is in the first state, the feeding end of the feeding module is in communication with the inlet of the first separation column, and the Lu-containing solution 177 The Lu raw solution, the elution solution and the desorption solution enter the first separation column in sequence to obtain a Lu-containing intermediate solution and a Lu-containing solution 177 The Lu-containing intermediate solution, and the Lu-containing solution 177 The Lu-containing intermediate solution enters the transfer container; In the case that the first reversing valve is in the second state, the feeding end of the feeding module is in communication with the inlet of the second separation column, and the Lu solution, the elution solution and the desorption solution enter the second separation column in sequence to obtain the carrier-free Lu solution by separation 177 Lu solution, the elution solution and the desorption solution enter the second separation column in sequence to obtain the carrier-free Lu solution by separation 177 Lu solution; The carrier-free 177 The system for preparing a Lu solution also comprises: a waste liquid container; a second switching valve, an outlet of the first separation column is connected with an inlet of the transit container and the waste liquid container through the second switching valve; the first separation column further generates a first waste liquid; when the second switching valve is in a third state, the outlet of the first separation column is communicated with the waste liquid container, and the first waste liquid enters the waste liquid container; with the transit vessel, the first separation column, and the second separation column in fluid communication with one another, and the second switch valve in the fourth state. 177 Lu intermediate fluid enters the transit vessel; and / or, a third switching valve, the outlet of the second separation column is connected with the waste liquid container through the third switching valve for containing the waste liquid of the second separation column 177 a collection container of Lu solution, the waste liquid container is connected; the second separation column also generates a second waste liquid; when the third switching valve is in a fifth state, the outlet of the second separation column is communicated with the waste liquid container, and the second waste liquid enters the waste liquid container; with the collection vessel, the carrier-free 177 the Lu solution into the collection vessel; The carrier-free 177 The system for preparing a Lu solution further comprises: A first radioactive detector, positioned between the outlet of the first separation column and the second reversing valve, is used to detect the radioactivity of the solution flowing out of the outlet of the first separation column. The detector detects radioactivity from... 177 In the event of gamma rays generated by Lu, the second reversing valve switches to the fourth state; and / or, a second radioactivity detector disposed between the outlet of the second separation column and the third switching valve for detecting radioactivity of a solution flowing out of the outlet of the second separation column, wherein the third switching valve switches to a sixth state when the second radioactivity detector detects the gamma rays generated by Lu. 177 the third switching valve switches to a sixth state when the second radioactivity detector detects the gamma rays generated by Lu. the first separation column is internally filled with cation exchange resin; the desorption liquid comprises an α-hydroxyisobutyric acid solution, when the first switching valve is in a first state, the α-hydroxyisobutyric acid solution enters the first separation column; The desorption solution further comprises hydrochloric acid, which enters the second separation column when the first switching valve is in the second state; the second separation column is filled with phosphorus-containing acid type chelating resin, which can adsorb 177 Lu.

2. The vector-free composition of claim 1 177 System for the preparation of a Lu solution, characterized in that, a first conducting pipe is communicated between the outlet of the first separation column and an inlet of the second switching valve, the first conducting pipe passes through a shielding channel of the first radiation detector; and / or, a second conducting pipe is communicated between the outlet of the second separation column and an inlet of the third switching valve, the second conducting pipe passes through a shielding channel of the second radiation detector.

3. The carrier- free of claim 1 177 System for the preparation of a Lu solution, characterized by the fact that it comprises The preparation system further comprises: a pressure applying device, an outlet of the pressure applying device is connected with the first separation column and the second separation column through the first switching valve; when the first switching valve is in the first state, the outlet of the pressure applying device is communicated with an inlet of the first separation column; and / or, when the first switching valve is in the second state, the outlet of the pressure applying device is communicated with an inlet of the second separation column.

4. The carrier- free of claim 1 177 System for the preparation of a Lu solution, characterized by the fact that it comprises The preparation system further comprises: a plurality of containers for storing the respective solutions 177 Lu stock solution, the elution solution, and the desorption solution a fourth switching valve, a plurality of inlets of the fourth switching valve are respectively communicated with the plurality of containers, and an outlet of the fourth switching valve is connected with an inlet of the first separation column and an inlet of the second separation column through the first switching valve.

5. The carrier- free of claim 4 177 System for the preparation of a Lu solution, characterized by the fact that The preparation system further comprises: a liquid level detector arranged in the plurality of containers and used for detecting liquid levels of liquids in the plurality of containers.

6. The carrier- free of claim 1 177 System for the preparation of a Lu solution, characterized by the fact that The preparation system further comprises: a column oven, the first separation column and the second separation column are arranged in the column oven.

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