Blood component separation system and control method
By constructing the optimal control model of blood pump and anticoagulation pump in the blood component separation system and using image recognition technology, dynamic intelligent regulation and automation control of the blood component separation process is achieved, and the problems of low separation efficiency, poor accuracy and low degree of automation in the existing technology are solved, the efficiency and accuracy of blood component separation are improved, and the quality and activity of components are ensured.
Patent Information
- Application Number
- CN202510293401.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-13
- Publication Date
- 2025-04-11
- Estimated Expiration
- 2045-03-13
AI Technical Summary
The existing blood component separation technology has low separation efficiency and poor accuracy, which can easily cause damage to blood samples, low degree of automation, complex operation, and easy to introduce artificial errors.
A blood component separation system was designed, and a dynamic intelligent control method was adopted. By constructing an optimal control model of blood pump and anticoagulation pump, and combining image recognition technology to optimize the centrifugal effect, it realized dynamic intelligent regulation and automated control of the blood component separation process.
It improves the efficiency and accuracy of blood components separation, reduces damage to blood samples, enhances the degree of automation of the system, reduces artificial errors, and ensures the quality and activity of isolated blood components.
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Figure CN119793723A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of blood separation, and in particular to a blood component separation system and a control method. Background Art
[0002] Blood component separation technology is widely used in many aspects such as blood transfusion therapy, diagnosis and treatment of blood diseases; traditional blood component separation methods often have many disadvantages, such as low separation efficiency, poor accuracy, and easy damage to blood samples. Some early centrifugal separation equipment, due to the lack of dynamic regulation of centrifugal force and precise control of key parameters such as flow rate and tube pressure during the separation process, made the separation boundaries between different blood components unclear, and blood cells frequently ruptured when rotating at high speed, seriously affecting the quality and activity of the separated components. Moreover, the existing blood component separation system has a low degree of automation, and the injection of anticoagulants is difficult to control, and manual intervention is frequent, which not only increases the workload of operators, but also easily introduces human errors, greatly reducing the overall reliability and stability. Summary of the invention
[0003] In view of the above-mentioned deficiencies in the prior art, the present invention provides a blood component separation system and a control method to achieve dynamic intelligent control of the blood component separation process.
[0004] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is: Provided is a blood component separation system, comprising a centrifugal device, wherein a liquid inlet of the centrifugal device is connected to a blood supply end through a blood supply blood channel, an air detector B, a valve A and a blood pump are sequentially arranged on the blood supply blood channel, a separation pipeline is connected to a liquid outlet of the centrifugal device, a first bifurcated tube and a second bifurcated tube are sequentially connected to the separation pipeline, the first bifurcated tube and the second bifurcated tube are respectively connected to a first plasma bag and a second plasma bag, and valves B and C are respectively arranged on the first bifurcated tube and the second bifurcated tube, a centrifugal pressure sensor for detecting the internal centrifugal chamber pressure and a centrifugal high-speed camera for taking images of the centrifugal separation effect of blood components are arranged in the centrifugal device, and a red blood cell sensor is arranged on the liquid outlet of the centrifugal device; It also includes a control center, which includes a data acquisition module, a data analysis module and a centrifugal control module. The centrifugal high-speed camera, air detector B, centrifugal pressure sensor, and red blood cell sensor are all electrically connected to the data acquisition module, and the centrifugal control module is electrically connected to the centrifugal device.
[0005] Furthermore, a tube pressure monitor is provided on the blood supply channel, and the tube pressure monitor is electrically connected to the data acquisition module.
[0006] Furthermore, an anticoagulation pump is connected between the air detector B and the blood supply end through an anticoagulation pipeline, and an air detector A is arranged on the anticoagulation pipeline between the anticoagulation pump and the air detector B. The anticoagulation pump is connected to the anticoagulant supply device, and a liquid level sensor is arranged in the anticoagulant supply device. The air detector A and the liquid level sensor are both electrically connected to the data acquisition module.
[0007] Furthermore, it also includes a fluid replenishing device, which is connected to a fluid replenishing pump. The fluid replenishing pump is connected to a separation pipeline through a fluid replenishing pipeline, and a valve D is provided on the separation pipeline.
[0008] Furthermore, it also includes a reinfusion pump, which is connected to the liquid outlet of the centrifugal device. The reinfusion pump is connected to the blood supply blood channel at the blood supply end through a valve E, and the remaining blood components in the centrifugal device are returned to the blood donor through the reinfusion pump.
[0009] A control method for a blood component separation system is provided, comprising: Step S1: During the blood collection process, the blood supply end transfuses blood into the centrifugal device through the blood pump, the anticoagulant pump extracts anticoagulant and inputs it into the blood supply channel, so that the blood in the blood supply channel is mixed with the anticoagulant, and the tube pressure monitor collects the tube pressure of the blood supply channel in real time, and constructs the optimal control model of the blood pump and the optimal control model of the anticoagulant pump based on the tube pressure; Step S2: regulating the power of the blood pump and the anticoagulation pump based on the optimal control model of the blood pump and the optimal control model of the anticoagulation pump, and inputting the collected blood into the centrifugal device; Step S3: After the blood collection is completed, valve A is closed, and the centrifugal device is started to rotate to centrifuge the blood components. The centrifugal high-speed camera takes a centrifugal image of the blood in real time, analyzes the centrifugal effect of the blood components based on the centrifugal image, and adjusts the centrifugal power of the centrifugal device; Step S4: After the centrifugal device completes the separation of blood components using a centrifugal power that meets the centrifugal requirements, valve B and valve C are opened in sequence to discharge the separated blood components into the first plasma bag and the second plasma bag, respectively.
[0010] Further, step S1 includes: Step S11: During the blood collection process, the blood supply end uses a blood pump to transfuse blood into the centrifugal device, and an anticoagulant pump extracts anticoagulant and inputs it into the blood supply channel to mix the blood in the blood supply channel with the anticoagulant. The tube pressure monitor collects the tube pressure of the blood supply channel in real time. , t The time when the pipe pressure is collected; Step S12: According to the pipe pressure Construct an optimal control model for the blood pump; ; in, for t+1 moment pipe pressure fluctuation value, is the efficiency of the blood pump, is the rated flow rate of blood at the blood collection end, Indicates taking the minimum value, Indicates taking the maximum value, for t The pipe pressure fluctuation value at the moment, for t -1 pipe pressure fluctuation value, for t +1 is the power control value of the blood pump at the moment, for t -1 moment pipe pressure, for t -2 pipe pressure at time, is the maximum power of the blood pump; Step S13: Output of the optimal control model of the blood pump t +1 blood pump power , The actual flow rate of blood in the blood transfusion channel is calculated based on the rated power of the blood pump. ; ; in, r is the radius of the blood transfusion tube, L is the length of the blood transfusion tube, It is the viscosity of blood flowing in the blood transfusion tube; Step S14: According to the actual flow rate of blood Construct the optimal control model of the anticoagulation pump; ; in, is the power of the anticoagulation pump, is the density of the anticoagulant, g is the acceleration due to gravity, is the ratio coefficient of anticoagulant needed to be added to the blood, H is the elevation of the anticoagulant delivery process, is the efficiency of the anticoagulation pump, It is the influence coefficient of the tube pressure fluctuation of the blood transfusion line on the delivery of anticoagulant.
[0011] Further, step S3 includes: Step S31: a centrifugal high-speed camera is used to take a centrifugal image of blood in real time, grayscale the centrifugal image to obtain a grayscale image, and obtain the grayscale value of each pixel on the grayscale image, and establish an identification area on the grayscale image, where the identification area is a strip area perpendicular to the stratification direction of blood components; Step S32: setting the color grayscale value after the target component in the blood is successfully separated, and filtering the pixel set in the area where each blood component is located according to the grayscale value of each pixel in the identification area; ; in, e The types of blood components. For the e The pixel set of the area where the blood components are located, E is the number of pixels in the pixel set, is a pixel in the pixel set, is a pixel in a pixel set The gray value of For pixel set e The grayscale value of the blood components after separation. is the color grayscale difference threshold; Step S33: According to the pixel set Internal Pixel The coordinates of the pixel coordinate set are established , filter the pixel coordinate set The maximum value of the pixel coordinates in the length direction of the recognition area and coordinate minimum , ; Step S34: Draw two coordinate maximum values in the recognition area. and coordinate minimum , and a wide side line of the blood component separation area which is perpendicular to the long side of the identification area, the two wide side lines and the long side lines on both sides of the identification area enclose the blood component separation area; Step S35: Divide the blood component separation area for each blood component in the identification area, and calculate the centrifugal effect coefficient according to the purity of the pixels in each blood component separation area f ; ; in, is the purity coefficient in the blood component separation area, W The blood component separation area does not belong to e The number of blood component pixels, U is the number of pixels in the blood component separation area, The blood component separation area does not belong to the e pixels of blood components, is the pixel set within the blood component separation area, is the weight of the centrifugal effect, X The number and types of blood components separated by centrifugation; Step S36: Setting the threshold of the centrifugal effect coefficient f 阈值 ; like , then the centrifugal power of the centrifugal device reaches the centrifugal requirement; like , the centrifugal power of the centrifugal device does not meet the centrifugal requirements, the centrifugal device needs to adjust the centrifugal power, and the centrifugal power regulation of the centrifugal device meets ,in, is the control coefficient of centrifugal power, , n is the number of centrifugal image acquisitions, For the n After the centrifugal power is adjusted, the centrifugal power of the centrifugal device returns to step S31.
[0012] The beneficial effects of the present invention are as follows: the present invention realizes dynamic intelligent regulation and automatic control of the centrifugal separation system of blood components, and adapts to the fluctuation of pressure in the blood transfusion channel by constructing the optimal control model of the blood pump and the anticoagulant pump, reduces the fluctuation of flow rate by dynamically adjusting the power of the blood pump, and adapts to the fluctuation of blood flow rate by dynamically adjusting the power of the anticoagulant pump, thereby improving the accuracy of anticoagulant delivery. In addition, the image recognition technology is used to optimize the centrifugal effect, which is superior to the photoelectric recognition technology of the prior art, and ensures the centrifugal quality while avoiding excessive centrifugation, effectively ensuring the quality and activity of the separated blood components. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 This is a schematic diagram of the blood component separation system.
[0014] Figure 2 This is the control principle block diagram of the blood component separation system.
[0015] Figure 3 Schematic diagram of the effect of blood component separation.
[0016] Among them, 1. liquid inlet, 2. liquid outlet, 3. centrifugal chamber, 4. plasma layer, 5. platelet layer, 6. red blood cell layer. DETAILED DESCRIPTION
[0017] The specific implementation modes of the present invention are described below so that those skilled in the art can understand the present invention. However, it should be clear that the present invention is not limited to the scope of the specific implementation modes. For those of ordinary skill in the art, as long as various changes are within the spirit and scope of the present invention as defined and determined by the attached claims, these changes are obvious, and all inventions and creations utilizing the concept of the present invention are protected.
[0018] like Figure 1As shown, a blood component separation system includes a centrifugal device, wherein a liquid inlet 1 of the centrifugal device is connected to a blood supply end through a blood supply blood channel, an air detector B, a valve A and a blood pump are sequentially arranged on the blood supply blood channel, a liquid outlet 2 of the centrifugal device is connected to a separation pipeline, a first bifurcated tube and a second bifurcated tube are sequentially connected to the separation pipeline, the first bifurcated tube and the second bifurcated tube are respectively connected to a first plasma bag and a second plasma bag, and valves B and C are respectively arranged on the first bifurcated tube and the second bifurcated tube, a centrifugal pressure sensor for detecting the pressure of an internal centrifugal chamber 3 and a centrifugal high-speed camera for taking images of centrifugal separation effects of blood components are arranged in the centrifugal device, and a red blood cell sensor is arranged on the liquid outlet 2 of the centrifugal device.
[0019] The air detector B is used to detect the air content in the blood transfusion line to see if there is a lot of air. The valve A controls the opening and closing of the blood transfusion line. The blood pump provides power for the blood transfusion process. In general, the separation of blood components generally requires the separation of the plasma layer 4, the platelet layer 5 and the red blood cell layer 6. Figure 3 As shown, the mass of plasma is the largest, and during the centrifugal separation process, the plasma layer 4 is located on the inner side, followed by platelets in the middle layer, and the mass of red blood cells is the smallest, and the separated red blood cell layer 6 is located on the outermost side.
[0020] like Figure 2 As shown, it also includes a control center, which includes a data acquisition module, a data analysis module and a centrifugal control module. The centrifugal high-speed camera, the air detector B, the centrifugal pressure sensor, and the red blood cell sensor are all electrically connected to the data acquisition module, and the centrifugal control module is electrically connected to the centrifugal device. The centrifugal control module is used to control the centrifugal power of the centrifugal device, and the data analysis module is used to analyze the data collected by the data acquisition module and output control instructions. The centrifugal pressure sensor is used to monitor the centrifugal pressure in the centrifugal chamber 3 during the centrifugal process to avoid the centrifugal speed being too fast, resulting in the rupture of the centrifugal chamber 3. In this embodiment, the centrifugal chamber 3 can adopt the blood centrifugal cup of the prior art, and the centrifugal cup adopts a transparent material and is used as a disposable consumable.
[0021] A tube pressure monitor is provided on the blood supply line, and the tube pressure monitor is electrically connected to the data acquisition module to detect the pressure on the blood supply line and provide real-time feedback to the data acquisition module.
[0022] An anticoagulation pump is connected between the air detector B and the blood supply end through an anticoagulation pipeline, and an air detector A is provided on the anticoagulation pipeline between the anticoagulation pump and the air detector B for monitoring whether there is air in the anticoagulation pipeline. The anticoagulation pump is connected to an anticoagulant supply device, and a liquid level sensor is provided in the anticoagulant supply device. The air detector A and the liquid level sensor are electrically connected to the data acquisition module, and the liquid level sensor monitors the liquid level height of the anticoagulant in the anticoagulant supply device.
[0023] It also includes a fluid infusion device, which is connected to a fluid infusion pump. The fluid infusion pump is connected to a separation pipeline through a fluid infusion pipeline. A valve D is provided on the separation pipeline. When the blood donor needs fluid infusion, after the blood components are separated, the remaining components are discharged, and fluid can be reversely supplied to the blood donor through the fluid infusion pump.
[0024] It also includes a reinfusion pump, which is connected to the liquid outlet of the centrifugal device. The reinfusion pump is connected to the blood supply blood channel at the blood supply end through a valve E. The remaining blood components in the centrifugal device are returned to the blood donor through the reinfusion pump. The valve E is opened only when returning the blood, and is closed at other times.
[0025] A control method for a blood component separation system, comprising: Step S1: During the blood collection process, the blood supply end transfuses blood into the centrifugal device through the blood pump, and the anticoagulant pump extracts the anticoagulant and inputs it into the blood supply channel to mix the blood and anticoagulant in the blood supply channel. The tube pressure monitor collects the tube pressure of the blood supply channel in real time, and constructs the optimal control model of the blood pump and the optimal control model of the anticoagulant pump based on the tube pressure. Step S1 specifically includes: Step S11: During the blood collection process, the blood supply end uses a blood pump to transfuse blood into the centrifugal device, and an anticoagulant pump extracts anticoagulant and inputs it into the blood supply channel to mix the blood in the blood supply channel with the anticoagulant. The tube pressure monitor collects the tube pressure of the blood supply channel in real time. , t The time when the pipe pressure is collected; Step S12: According to the pipe pressure Construct an optimal control model for the blood pump; ; in, for t +1 moment pipe pressure fluctuation value, is the efficiency of the blood pump, is the rated flow rate of blood at the blood collection end, Indicates taking the minimum value, Indicates taking the maximum value, for t The pipe pressure fluctuation value at the moment, for t -1 pipe pressure fluctuation value, for t +1 is the power control value of the blood pump at the moment, for t -1 moment pipe pressure, for t -2 pipe pressure at time, is the maximum power of the blood pump; Step S13: Output of the optimal control model of the blood pump t +1 blood pump power , The actual flow rate of blood in the blood transfusion channel is calculated based on the rated power of the blood pump. ; ; in, r is the radius of the blood transfusion tube, L is the length of the blood transfusion tube, It is the viscosity of blood flowing in the blood transfusion tube; Step S14: According to the actual flow rate of blood Construct the optimal control model of the anticoagulation pump; ; in, is the power of the anticoagulation pump, is the density of the anticoagulant, g is the acceleration due to gravity, is the ratio coefficient of anticoagulant needed to be added to the blood, H is the elevation of the anticoagulant delivery process, is the efficiency of the anticoagulation pump, is the influence coefficient of the pressure fluctuation of the blood transfusion channel on the anticoagulant delivery. The pressure fluctuation of the blood transfusion channel will directly affect the blood flow rate. The increase of the pressure in the mathematical pipeline will reversely give the anticoagulant resistance and reduce the flow rate of the anticoagulant delivery. The general influence coefficient Take 0.1-0.5 as the pressure fluctuation of the blood transfusion channel is greater, the influence coefficient The larger the blood flow rate, the greater the value. Dynamically regulate the power of the anticoagulation pump.
[0026] Step S2: Based on the optimal control model of the blood pump and the optimal control model of the anticoagulation pump, the power of the blood pump and the anticoagulation pump are regulated, and the collected blood is input into the centrifugal device.
[0027] Step S3: After the blood is collected, valve A is closed, the centrifugal device is started to rotate, and the blood components are centrifuged. The centrifugal high-speed camera takes a real-time centrifugal image of the blood, analyzes the centrifugal effect of the blood components based on the centrifugal image, and adjusts the centrifugal power of the centrifugal device. Step S3 specifically includes: Step S31: a centrifugal high-speed camera is used to take a centrifugal image of blood in real time, grayscale the centrifugal image to obtain a grayscale image, and obtain the grayscale value of each pixel on the grayscale image, and establish an identification area on the grayscale image, where the identification area is a strip area perpendicular to the stratification direction of blood components; Step S32: setting the color grayscale value after the target component in the blood is successfully separated, and filtering the pixel set in the area where each blood component is located according to the grayscale value of each pixel in the identification area; ; in, e The types of blood components. For the e The pixel set of the area where the blood components are located, E is the number of pixels in the pixel set, is a pixel in the pixel set, is a pixel in a pixel set The gray value of For pixel set e The color grayscale value after successful separation of the blood components is used as the standard value for evaluating the color grayscale values after separation of different blood components. is the color grayscale difference threshold, which is the allowable value of the color grayscale difference. This indicates that the pixels are not of the same blood component; Step S33: According to the pixel set Internal Pixel The coordinates of the pixel coordinate set are established , filter the pixel coordinate set The maximum value of the pixel coordinates in the length direction of the recognition area and coordinate minimum , ; Step S34: Draw two coordinate maximum values in the recognition area. and coordinate minimum , and the wide side line of the blood component separation area is perpendicular to the long side of the identification area, and the two wide side lines and the long side lines on both sides of the identification area enclose the blood component separation area; Figure 3 As shown, the separated plasma layer 4, platelet layer 5 and red blood cell layer 6 in this embodiment are distributed from left to right in the image area within the identification area.
[0028] Step S35: Divide the blood component separation area for each blood component in the identification area, and calculate the centrifugal effect coefficient according to the purity of the pixels in each blood component separation area f ; ; in, is the purity coefficient in the blood component separation area, W The blood component separation area does not belong to e The number of blood component pixels, U is the number of pixels in the blood component separation area, The blood component separation area does not belong to the e In this embodiment, e =3, is the pixel set within the blood component separation area, is the weight of the centrifugal effect, X The number and types of blood components separated by centrifugation; Step S36: Setting the threshold of the centrifugal effect coefficient f 阈值 ; like , then the centrifugal power of the centrifugal device reaches the centrifugal requirement; like , the centrifugal power of the centrifugal device does not meet the centrifugal requirements, the centrifugal device needs to adjust the centrifugal power, and the centrifugal power regulation of the centrifugal device meets ,in, is the control coefficient of centrifugal power, , n is the number of centrifugal image acquisitions, For the n After the centrifugal power is adjusted, the centrifugal power of the centrifugal device returns to step S31.
[0029] Step S4: After the centrifugal device uses the centrifugal power that meets the centrifugal requirements to complete the separation of blood components, valves B and valves C are opened in sequence to discharge the separated blood components into the first plasma bag and the second plasma bag, respectively. During the centrifugal process, the plasma layer 4 located on the inner side is first discharged into the first plasma bag, and the red blood cell sensor monitors the content of red blood cells in the plasma flowing into the first plasma bag in real time. When the content of red blood cells is too high, indicating that the plasma and platelets have all entered the first plasma bag, valve B is closed, and platelet-rich plasma is obtained in the first plasma bag. The remaining red blood cells can be returned to the transfusion donor. After the first plasma bag is full, valve C can be opened to enter the second plasma bag.
[0030] The present invention realizes dynamic intelligent regulation and automatic control of the centrifugal separation system of blood components. By constructing the optimal control model of the blood pump and the anticoagulant pump, the pressure fluctuation in the blood transfusion channel is adapted to reduce the flow fluctuation by dynamically adjusting the power of the blood pump, and the power of the anticoagulant pump is dynamically adjusted to adapt to the fluctuation of blood flow, thereby improving the accuracy of anticoagulant delivery. In addition, the image recognition technology is used to optimize the centrifugal effect, which is superior to the photoelectric recognition technology of the prior art. It ensures the centrifugal quality while avoiding excessive centrifugation, and effectively guarantees the quality and activity of the separated blood components.
Claims
1. A blood component separation system, characterized in that: It comprises a centrifugal device, wherein the liquid inlet of the centrifugal device is connected to the blood supply end through a blood supply blood channel, the blood supply blood channel is sequentially provided with an air detector B, a valve A and a blood pump, the liquid outlet of the centrifugal device is connected with a separation pipeline, the separation pipeline is sequentially connected with a first bifurcated tube and a second bifurcated tube, the first bifurcated tube and the second bifurcated tube are respectively connected to a first plasma bag and a second plasma bag, and valves B and C are respectively provided on the first bifurcated tube and the second bifurcated tube, the centrifugal device is provided with a centrifugal pressure sensor for detecting the internal centrifugal chamber pressure, and a centrifugal high-speed camera for taking images of the centrifugal separation effect of blood components, and a red blood cell sensor is provided on the liquid outlet of the centrifugal device; It also includes a control center, which includes a data acquisition module, a data analysis module and a centrifugal control module. The centrifugal high-speed camera, air detector B, centrifugal pressure sensor, and red blood cell sensor are all electrically connected to the data acquisition module, and the centrifugal control module is electrically connected to the centrifugal device.
2. The blood component separation system according to claim 1, characterized in that: The blood supply channel is provided with a tube pressure monitor, and the tube pressure monitor is electrically connected to the data acquisition module.
3. The blood component separation system according to claim 1, characterized in that: An anticoagulation pump is connected between the air detector B and the blood supply end through an anticoagulation pipeline, and an air detector A is arranged on the anticoagulation pipeline between the anticoagulation pump and the air detector B. The anticoagulation pump is connected to an anticoagulant supply device, and a liquid level sensor is arranged in the anticoagulant supply device. The air detector A and the liquid level sensor are both electrically connected to the data acquisition module.
4. The blood component separation system according to claim 1, characterized in that: It also includes a fluid replenishment device, which is connected to a fluid replenishment pump. The fluid replenishment pump is connected to a separation pipeline through a fluid replenishment pipeline, and a valve D is provided on the separation pipeline.
5. The blood component separation system according to claim 1, characterized in that: It also includes a reinfusion pump, which is connected to the liquid outlet of the centrifugal device. The reinfusion pump is connected to the blood supply blood channel at the blood supply end through a valve E. The remaining blood components in the centrifugal device are returned to the blood donor through the reinfusion pump.
6. A control method for a blood component separation system, characterized in that: include: Step S1: During the blood collection process, the blood supply end transfuses blood into the centrifugal device through the blood pump, the anticoagulant pump extracts anticoagulant and inputs it into the blood supply channel, so that the blood in the blood supply channel is mixed with the anticoagulant, and the tube pressure monitor collects the tube pressure of the blood supply channel in real time, and constructs the optimal control model of the blood pump and the optimal control model of the anticoagulant pump based on the tube pressure; Step S2: regulating the power of the blood pump and the anticoagulation pump based on the optimal control model of the blood pump and the optimal control model of the anticoagulation pump, and inputting the collected blood into the centrifugal device; Step S3: After the blood collection is completed, valve A is closed, and the centrifugal device is started to rotate to centrifuge the blood components. The centrifugal high-speed camera takes a centrifugal image of the blood in real time, analyzes the centrifugal effect of the blood components based on the centrifugal image, and adjusts the centrifugal power of the centrifugal device; Step S4: After the centrifugal device completes the separation of blood components using a centrifugal power that meets the centrifugal requirements, valve B and valve C are opened in sequence to discharge the separated blood components into the first plasma bag and the second plasma bag, respectively.
7. The control method of the blood component separation system according to claim 6, characterized in that: The step S1 comprises: Step S11: During the blood collection process, the blood supply end uses a blood pump to transfuse blood into the centrifugal device, and an anticoagulant pump extracts anticoagulant and inputs it into the blood supply channel to mix the blood in the blood supply channel with the anticoagulant. The tube pressure monitor collects the tube pressure of the blood supply channel in real time. , t The time when the pipe pressure is collected; Step S12: According to the pipe pressure Construct an optimal control model for the blood pump; ; in, for t +1 moment pipe pressure fluctuation value, is the efficiency of the blood pump, is the rated flow rate of blood at the blood collection end, Indicates taking the minimum value, Indicates taking the maximum value, for t The pipe pressure fluctuation value at the moment, for t -1 pipe pressure fluctuation value, for t +1 is the power control value of the blood pump at the moment, for t -1 moment pipe pressure, for t -2 pipe pressure at time, is the maximum power of the blood pump; Step S13: Output of the optimal control model of the blood pump t +1 blood pump power , The actual flow rate of blood in the blood transfusion channel is calculated based on the rated power of the blood pump. ; ; in, r is the radius of the blood transfusion tube, L is the length of the blood transfusion tube, It is the viscosity of blood flowing in the blood transfusion tube; Step S14: According to the actual flow rate of blood Construct the optimal control model of the anticoagulation pump; ; in, is the power of the anticoagulation pump, is the density of the anticoagulant, g is the acceleration due to gravity, is the ratio coefficient of anticoagulant needed to be added to the blood, H is the elevation of the anticoagulant delivery process, is the efficiency of the anticoagulation pump, It is the influence coefficient of the tube pressure fluctuation of the blood transfusion line on the delivery of anticoagulant.
8. The control method of the blood component separation system according to claim 7, characterized in that: The step S3 comprises: Step S31: a centrifugal high-speed camera is used to take a centrifugal image of blood in real time, grayscale the centrifugal image to obtain a grayscale image, and obtain the grayscale value of each pixel on the grayscale image, and establish an identification area on the grayscale image, where the identification area is a strip area perpendicular to the stratification direction of blood components; Step S32: setting the color grayscale value after the target component in the blood is successfully separated, and filtering the pixel set in the area where each blood component is located according to the grayscale value of each pixel in the identification area; ; in, e The types of blood components. For the e The pixel set of the area where the blood components are located, E is the number of pixels in the pixel set, is a pixel in the pixel set, is a pixel in a pixel set The gray value of For pixel set e The grayscale value of the blood components after separation. is the color grayscale difference threshold; Step S33: According to the pixel set Internal Pixel The coordinates of the pixel coordinate set are established , filter the pixel coordinate set The maximum value of the pixel coordinates in the length direction of the recognition area and coordinate minimum , ; Step S34: Draw two coordinate maximum values in the recognition area. and coordinate minimum , and a wide side line of the blood component separation area which is perpendicular to the long side of the identification area, the two wide side lines and the long side lines on both sides of the identification area enclose the blood component separation area; Step S35: Divide the blood component separation area for each blood component in the identification area, and calculate the centrifugal effect coefficient according to the purity of the pixels in each blood component separation area f ; ; in, is the purity coefficient in the blood component separation area, W The blood component separation area does not belong to e The number of blood component pixels, U is the number of pixels in the blood component separation area, It is not in the blood component separation area. e Pixels of blood components, is the pixel set within the blood component separation area, is the weight of the centrifugal effect, X The number and types of blood components separated by centrifugation; Step S36: Setting the threshold of the centrifugal effect coefficient f 阈值 ; like , then the centrifugal power of the centrifugal device reaches the centrifugal requirement; like , the centrifugal power of the centrifugal device does not meet the centrifugal requirements, the centrifugal device needs to adjust the centrifugal power, and the centrifugal power regulation of the centrifugal device meets ,in, is the control coefficient of centrifugal power, , n is the number of centrifugal image acquisitions, For the n After the centrifugal power is adjusted, the centrifugal power of the centrifugal device returns to step S31.
Citation Information
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