Bacillus velezensis yf01 preparation for degrading creatinine and application thereof
By using the fermentation preparation method of Bacillus belyss YF01 strain and its enzymes, the problems of insignificant drug efficacy and low microbial efficiency in existing CKD treatments have been solved, achieving highly efficient biodegradation of creatinine.
CN119799566BActive Publication Date: 2026-07-24BEIJING BEIKE YIRAN BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202411972102.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2026-07-24
- Estimated Expiration
- 2044-12-30
AI Technical Summary
Technical Problem
Current CKD treatment strategies suffer from problems such as insignificant effects of drugs in lowering serum creatinine levels and the presence of side effects, as well as low efficiency in microbial degradation of creatinine.
Method used
Using Bacillus vesiculus strain YF01 and its produced enzymes, a Bacillus vesiculus preparation YF01 was prepared through fermentation, centrifugation, and crushing for efficient biodegradation of creatinine.
Benefits of technology
Bacillus vesiculosus strain YF01 can completely degrade creatinine at an initial concentration of 500 mg/L within 48 hours, while crude enzyme achieves the same effect within 24 hours, providing a highly efficient creatinine removal solution with few side effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The application belongs to the technical field of biology and relates to a Bysinum perfringens YF01 strain capable of producing an enzyme for catalyzing degradation of creatinine. The application also relates to a Bysinum perfringens YF01 preparation for degrading creatinine, which contains bacterial cells and / or crude enzymes of the Bysinum perfringens YF01 strain. Research results show that the Bysinum perfringens YF01 cell and the enzyme produced by the Bysinum perfringens YF01 cell can respectively degrade 500 mg / L of creatinine within 48 hours and 24 hours, and have important application prospects in reducing human blood creatinine levels and preventing and treating kidney diseases and corresponding complications.
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