Toothpaste for removing dental plaque and preparation method thereof

Abstract

The invention relates to toothpaste for removing dental plaque and a preparation method thereof, the toothpaste is prepared from a composition for removing dental plaque, a friction agent, a thickening agent, a foaming agent and water, and the composition for removing dental plaque comprises a honeysuckle extract, a rosemary extract, a mangnolia officinalis extract, a chamomile flower extract and a pseudo-ginseng extract. The toothpaste prepared by the invention has the effects of removing dental plaque and whitening teeth, and the honeysuckle extract, the rosemary extract, the mangnolia officinalis extract, the chamomilla recutita flower extract and the pseudo-ginseng extract have a certain synergistic effect on the effects.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities and relates to a toothpaste for removing dental plaque and a preparation method thereof. Background Art

[0002] In the field of oral health care, the removal of dental plaque has always been a critical research and practice topic. With the increasing attention paid to oral health and the profound changes in modern lifestyles, the development of toothpaste that can effectively remove dental plaque has important background significance and urgent needs.

[0003] Dental plaque is a bacterial biofilm attached to the surface of teeth, gingival margins and restoration surfaces. It is composed of a large number of bacteria, bacterial metabolites, salivary proteins and food residues. The bacteria in dental plaque, especially mutans streptococci and actinomycetes, metabolize carbohydrates as substrates in the oral environment and produce acidic substances such as lactic acid. These acidic substances can cause minerals in the hard tissues of teeth to dissolve, leading to demineralization and the formation of caries. Long-term accumulation of dental plaque can also irritate the gingival tissue and cause gingival inflammation, which is initially manifested as redness, swelling and bleeding of the gums. If not controlled in time, the inflammation can gradually spread deep into the periodontal tissue and develop into periodontitis, leading to the formation of periodontal pockets and alveolar bone absorption, which may eventually cause loose teeth or even loss. In addition, dental plaque is also one of the important causes of bad breath. The volatile sulfides and other odor substances it produces seriously affect people's social and quality of life.

[0004] Due to the serious harm of dental plaque to oral health, there is an urgent need to develop a toothpaste that can remove dental plaque comprehensively, efficiently and safely. Summary of the invention

[0005] In view of the deficiencies in the prior art, the object of the present invention is to provide a toothpaste for removing dental plaque and a preparation method thereof.

[0006] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0007] In a first aspect, the present invention provides a toothpaste for removing dental plaque, wherein the raw materials for preparing the toothpaste include a dental plaque removing composition, an abrasive, a thickener, a foaming agent and water, and the dental plaque removing composition includes honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and Panax notoginseng extract.

[0008] The toothpaste prepared by the invention has the effects of removing dental plaque and whitening, and the honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and notoginseng extract have a certain synergistic effect on the above effects.

[0009] Preferably, the raw materials for preparing the toothpaste include, by mass, 0.5-4 parts of a plaque removing composition, 18-25 parts of an abrasive, 0.5-2 parts of a thickener, 2-5 parts of a foaming agent and 22-28 parts of water.

[0010] The mass fraction of the plaque removal composition can be selected from 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, etc., the mass fraction of the abrasive can be selected from 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, etc., the mass fraction of the thickener can be selected from 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., the mass fraction of the foaming agent can be selected from 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc., the mass fraction of water can be selected from 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, etc., and other specific points within the above numerical range can be selected, which will not be elaborated here.

[0011] Preferably, the dental plaque removal composition comprises, by mass, 1-4 parts of honeysuckle extract, 0.5-2 parts of rosemary extract, 0.5-2 parts of magnolia bark extract, 0.2-1 parts of chamomile extract and 0.5-2 parts of Panax notoginseng extract.

[0012] The mass fraction of honeysuckle extract can be selected from 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, etc., the mass fraction of rosemary extract can be selected from 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., the mass fraction of magnolia bark extract can be selected from 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., the mass fraction of chamomile flower extract can be selected from 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, etc., the mass fraction of Panax notoginseng extract can be selected from 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., and other specific point values ​​within the above numerical range can be selected, which will not be repeated here one by one.

[0013] Preferably, the foaming agent comprises sodium lauroyl sarcosinate and / or cocamidopropyl betaine.

[0014] Preferably, the abrasive comprises calcium carbonate and / or hydrated silica.

[0015] Preferably, the thickener comprises hydroxypropyl guar gum.

[0016] Preferably, the raw materials for preparing the toothpaste for removing dental plaque further include any one of a moisturizer, a preservative, a chelating agent, a pH regulator, and a flavor, or a combination of at least two of them.

[0017] Preferably, the raw materials for preparing the toothpaste for removing dental plaque further include, by weight, any one of 40-50 parts of moisturizer, 0.1-0.8 parts of preservative, 0.1-1 parts of chelating agent, 0.1-1 parts of pH adjuster or 0.1-1.5 parts of flavor, or a combination of at least two of them.

[0018] The mass fraction of moisturizer can be selected from 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 ​​parts, 49 parts, 50 parts, etc., the mass fraction of preservative can be selected from 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, etc., the mass fraction of chelating agent can be selected from 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 parts, etc., the mass fraction of pH adjuster can be selected from 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 parts, etc., the mass fraction of flavor can be selected from 0.1 parts, 0.3 parts, 0.5 parts, 0.7 parts, 0.9 parts, 1.1 parts, 1.3 parts, 1.5 parts, etc., and other specific point values ​​within the above numerical range can be selected, so they will not be described one by one here.

[0019] Preferably, the pH adjuster comprises sodium hydroxide.

[0020] Preferably, the preservative comprises sodium benzoate.

[0021] Preferably, the humectant comprises glycerin.

[0022] Preferably, the chelating agent comprises EDTA-disodium.

[0023] In a second aspect, the present invention provides a method for preparing a toothpaste for removing dental plaque according to the first aspect, the preparation method comprising: physically mixing the preparation raw materials and defoaming to obtain the toothpaste.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The toothpaste prepared by the invention has the effects of removing dental plaque and whitening teeth, and the honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and notoginseng extract have a certain synergistic effect on the above effects. DETAILED DESCRIPTION

[0026] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0027] The sources of the functional ingredients contained in the products involved in the following embodiments and comparative examples are as follows (only the functional ingredients are reflected, and the necessary auxiliary ingredients contained in other commercially available raw materials are not repeated):

[0028] The honeysuckle extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of honeysuckle extract;

[0029] Rosemary extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of Rosemary Extract;

[0030] Magnolia officinalis extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name Magnolia officinalis extract;

[0031] The chamomile flower extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of chamomile flower extract;

[0032] The Panax notoginseng extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name Panax notoginseng extract;

[0033] The fragrance was purchased from Givaudan Fragrances & Fragrances (Shanghai) Co., Ltd. with the trade name of Supreme Rose Upgraded Edition AAN45285 / 00.

[0034] Example 1

[0035] The present embodiment provides a composition for removing dental plaque, which comprises, by mass, 2 parts of honeysuckle extract, 1 part of rosemary extract, 1 part of magnolia bark extract, 0.5 parts of chamomile extract and 1 part of Panax notoginseng extract.

[0036] The preparation method thereof is as follows: physically mixing the preparation raw materials to obtain the product.

[0037] Example 2

[0038] The present embodiment provides a composition for removing dental plaque, which comprises, by mass, 4 parts of honeysuckle extract, 0.5 parts of rosemary extract, 0.5 parts of magnolia bark extract, 1 part of chamomile extract and 2 parts of Panax notoginseng extract.

[0039] The preparation method is similar to that of Example 1.

[0040] Example 3

[0041] The present embodiment provides a composition for removing dental plaque, which comprises, by mass, 1 part of honeysuckle extract, 2 parts of rosemary extract, 2 parts of magnolia bark extract, 0.2 parts of chamomile extract and 0.5 parts of Panax notoginseng extract.

[0042] The preparation method is similar to that of Example 1.

[0043] Comparative Example 1

[0044] This comparative example provides a composition for removing dental plaque, which differs from Example 1 only in that it does not contain honeysuckle extract, and its reduced mass is proportionally distributed to the mass of rosemary extract, magnolia bark extract, chamomile extract and Panax notoginseng extract, and other ingredients and contents remain unchanged.

[0045] The preparation method is similar to that of Example 1.

[0046] Comparative Example 2

[0047] This comparative example provides a composition for removing dental plaque, which differs from Example 1 only in that it does not contain rosemary extract, and its reduced mass is proportionally distributed to the mass of honeysuckle extract, magnolia bark extract, chamomile extract and Panax notoginseng extract, while other ingredients and contents remain unchanged.

[0048] The preparation method is similar to that of Example 1.

[0049] Comparative Example 3

[0050] This comparative example provides a composition for removing dental plaque, which differs from Example 1 only in that it does not contain Magnolia officinalis extract, and its reduced mass is proportionally distributed to the mass of honeysuckle extract, rosemary extract, chamomile extract and Panax notoginseng extract, and other ingredients and contents remain unchanged.

[0051] The preparation method is similar to that of Example 1.

[0052] Comparative Example 4

[0053] This comparative example provides a composition for removing dental plaque, which differs from Example 1 only in that it does not contain chamomile extract, and its reduced mass is proportionally distributed to the mass of honeysuckle extract, rosemary extract, magnolia bark extract and Panax notoginseng extract, while other ingredients and contents remain unchanged.

[0054] The preparation method is similar to that of Example 1.

[0055] Comparative Example 5

[0056] This comparative example provides a composition for removing dental plaque, which differs from Example 1 only in that it does not contain Panax notoginseng extract, and its reduced mass is proportionally distributed to the mass of honeysuckle extract, rosemary extract, chamomile extract and magnolia bark extract, while other ingredients and contents remain unchanged.

[0057] The preparation method is similar to that of Example 1.

[0058] Application Example 1

[0059] This application example provides a toothpaste for removing dental plaque, which includes, by mass, 2 parts of the composition for removing dental plaque in Example 1, 7 parts of calcium carbonate, 14 parts of hydrated silica, 0.9 parts of hydroxypropyl guar gum, 2.4 parts of sodium lauroyl sarcosinate, 0.7 parts of cocamidopropyl betaine, 43 parts of glycerin, 0.25 parts of sodium benzoate, 0.5 parts of disodium EDTA, 0.15 parts of sodium hydroxide, 0.95 parts of flavor and 24 parts of water.

[0060] The preparation method comprises the following steps: physically mixing the raw materials and defoaming to obtain the product.

[0061] Application Example 2

[0062] This application example provides a toothpaste for removing dental plaque, which includes, by mass, 4 parts of the composition for removing dental plaque in Example 2, 7 parts of calcium carbonate, 11 parts of hydrated silica, 0.5 parts of hydroxypropyl guar gum, 1 part of sodium lauroyl sarcosinate, 1 part of cocamidopropyl betaine, 40 parts of glycerin, 0.1 part of sodium benzoate, 0.1 part of disodium EDTA, 0.1 part of sodium hydroxide, 0.2 parts of flavor and 28 parts of water.

[0063] The preparation method refers to Application Example 1.

[0064] Application Example 3

[0065] This application example provides a toothpaste for removing dental plaque, which includes, by mass, 0.5 parts of the composition for removing dental plaque in Example 3, 7 parts of calcium carbonate, 18 parts of hydrated silica, 2 parts of hydroxypropyl guar gum, 3 parts of sodium lauroyl sarcosinate, 2 parts of cocamidopropyl betaine, 50 parts of glycerin, 0.5 parts of sodium benzoate, 0.8 parts of disodium EDTA, 0.8 parts of sodium hydroxide, 1 part of flavor and 22 parts of water.

[0066] The preparation method refers to Application Example 1.

[0067] Comparative Application Examples 1-5

[0068] This comparative application example provides 5 kinds of toothpastes for removing dental plaque, which differ from application example 1 only in that the dental plaque removing composition of example 1 is replaced by the compositions of comparative examples 1-5 in equal amounts, and other ingredients and contents remain unchanged.

[0069] The preparation method refers to Application Example 1.

[0070] Test Example 1

[0071] Plaque test

[0072] 1. Test principle: Streptococcus mutans (S. mutans) is the main bacteria in dental plaque that causes dental diseases. Taking mutans streptococcus as the research object, a toothbrush with toothpaste squeezed on it was used to brush the bovine tooth module with mutans streptococcus 50 times, and the number of residual colonies on the bovine tooth module was recovered. The removal rate of dental plaque by the toothpaste was calculated by comparing the number of colonies recovered from the bovine tooth module that was not brushed with a toothbrush.

[0073] 2. Test method:

[0074] Take mutans Streptococcus CICC10387 and inoculate it on TSA agar plate, and culture it anaerobically at 36℃±1℃ for 60h. Use an inoculation loop to take a typical colony of the first generation culture, streak it on TSA agar plate, and culture it anaerobically at 36℃±1℃ for 60h to obtain the second generation culture. Pick and separate the fresh colonies of the third generation, mix them with PBS, and adjust the bacterial concentration to 10 8 CFU / mL, and prepare bacterial suspension for later use.

[0075] Place 54 sterilized bovine tooth modules in sterile bottles, add 10 mL of bacterial suspension and 10 mL of BHI broth to each bottle and culture anaerobically at 36°C ± 1°C for 24 h.

[0076] 54 bovine teeth were equally divided into 9 groups, with 48 teeth in the sample group (6 teeth in each group) and 6 teeth in the control group. An unused toothbrush was used in the sample group, and about 1g of toothpaste was squeezed on the toothbrush. The bovine teeth were fixed and brushed with the toothbrush 50 times back and forth for 7 consecutive days. The toothpaste foam on the surface of the bovine teeth was rinsed off with sterile water, and then the bovine teeth were placed in a sterile homogenizing bag and eluted with 20mL SCDLP. After anaerobic culture at 36℃±1℃ for 60h, the teeth were counted and the average value was recorded as A CFU.

[0077] Six unbrushed bovine teeth were placed in a sterile homogenization bag, each containing 20 mL of SCDLP for elution, and after anaerobic culture at 36°C ± 1°C for 60 h, the teeth were counted and the average value was recorded as B CFU.

[0078] Colony counts were counted in the range of 30 to 300. For each replicate, the number of colonies was calculated by multiplying the number read on the plate by the dilution factor.

[0079] Clearance (%) = (BA) / B × 100%

[0080] Table 1

[0081] Group Clearance rate (%) Application Example 1 99.99 Application Example 2 96.87 Application Example 3 94.12 Comparative application example 1 62.58 Comparative Application Example 2 63.44 Comparative Application Example 3 70.23 Comparative Application Example 4 67.20 Comparative Application Example 5 62.16

[0082] It can be seen from the data in Table 1 that the toothpaste of the present invention has a good effect in removing dental plaque, and has a good clearing effect on Streptococcus mutans that causes dental plaque, and the honeysuckle extract, rosemary extract, Magnolia officinalis extract, chamomile extract and Panax notoginseng extract have a certain synergistic effect.

[0083] Test Example 2

[0084] 1. Test principle: There is a layer of acquired film with strong adhesion on the surface of teeth. Bacteria decompose food in teeth or dark-colored food or beverages in daily diet, such as black tea, soy sauce, chocolate, coffee, etc., will color the acquired film and gradually accumulate to form exogenous stains that are difficult to prevent. This method uses bovine teeth as substrates, artificially dyes them to obtain exogenous stains, simulates the brushing process, uses a colorimeter to measure the difference in tooth color, and evaluates the effectiveness of toothpaste in preventing exogenous stains.

[0085] 2. Samples to be tested: Application examples 1-3, comparative application examples 1-5

[0086] 3. Test method:

[0087] (1) Select a non-caries bovine tooth and prepare a clean and sterilized enamel specimen.

[0088] (2) After rinsing and drying the tooth blocks, use a colorimeter to measure the whiteness value of the enamel surface of each tooth block. Select tooth blocks with similar whiteness values ​​and randomly group them into groups, with 8 in each group.

[0089] (3) Prepare a sample toothpaste slurry in a mass ratio of 1:3 between toothpaste and water, and use the sample toothpaste slurry to simulate brushing teeth for 800 times at 100 times / min. Then, rinse the tooth blocks and dry them, and measure the whiteness value (Lfront) of the enamel surface of each tooth block with a colorimeter.

[0090] (4) Rinse the tooth block after brushing and place it in the prepared staining solution for staining for 48 hours.

[0091] The dye sources used in this experiment are black tea, coffee, soy sauce, and ferric chloride.

[0092] (5) Take out the tooth blocks from the staining solution, rinse them, dry them, and use a colorimeter to measure the whiteness value (L) of the enamel surface of each tooth block.

[0093] (6) Calculate the whiteness value difference △L of the sample group and the control group before and after simulated brushing.

[0094] △L=L rear-L front

[0095] Table 2

[0096] △L Application Example 1 -22.1 Application Example 2 -23.6 Application Example 3 -25.8 Comparative application example 1 -30.4 Comparative Application Example 2 -31.2 Comparative Application Example 3 -29.1 Comparative Application Example 4 -33.2 Comparative Application Example 5 -32.4

[0097] It can be seen from the data in Table 2 that the toothpaste prepared by the present invention has a certain preventive ability for stains, and the honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and Panax notoginseng extract have a certain synergistic effect.

[0098] Test Example 3

[0099] Whitening effect test

[0100] Test method:

[0101] (1) Select a tooth without caries and clean and sterilize it.

[0102] (2) Soak the tooth block in 1% hydrochloric acid, saturated sodium carbonate, and 1% phytic acid alternately for 1 min each, rinse it clean, and place it in the prepared staining solution for 48 hours. The staining source used in this experiment is a mixture of black tea, coffee, soy sauce, and ferric chloride.

[0103] (3) Take out the tooth blocks from the staining solution, rinse them, dry them, and use a colorimeter to measure the whiteness value of the enamel surface of each tooth block, which is recorded as L before.

[0104] (4) The tooth blocks were randomly divided into groups, with 8 in each group, and analysis software was used to perform a difference test. No significant difference was found between the groups.

[0105] (5) The sample and water were mixed in a mass ratio of 1:3 to prepare toothpaste slurry. The tooth blocks of each group were simulated brushing with the same amount of toothpaste slurry twice a day for 7 days.

[0106] (6) After rinsing the tooth block after simulating toothbrushing, dry it and use a colorimeter to measure the whiteness value of the enamel surface of the tooth block, which is recorded as L.

[0107] (7) Calculate the whiteness value difference △L before and after the simulated brushing respectively, and the calculation formula is as follows:

[0108] △L=L rear-L front

[0109] Table 3

[0110] △L Application Example 1 17.69 Application Example 2 16.72 Application Example 3 16.27 Comparative application example 1 14.21 Comparative Application Example 2 13.65 Comparative Application Example 3 13.14 Comparative Application Example 4 12.85 Comparative Application Example 5 12.41

[0111] It can be seen from the data in Table 3 that the toothpaste prepared by the present invention has a certain whitening effect, and the honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and Panax notoginseng extract have a certain synergistic effect.

[0112] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a toothpaste for removing dental plaque and a preparation method thereof, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0113] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0114] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A toothpaste for removing dental plaque, characterized in that: The raw materials for preparing the toothpaste include a dental plaque removing composition, an abrasive, a thickener, a foaming agent and water. The dental plaque removing composition includes honeysuckle extract, rosemary extract, magnolia bark extract, chamomile extract and notoginseng extract.

2. The toothpaste for removing dental plaque according to claim 1, characterized in that: The raw materials for preparing the toothpaste include, by weight, 0.5-4 parts of a plaque removing composition, 18-25 parts of an abrasive, 0.5-2 parts of a thickener, 2-5 parts of a foaming agent and 22-28 parts of water.

3. The toothpaste for removing dental plaque according to claim 1 or 2, characterized in that: The dental plaque removing composition comprises, by weight, 1-4 parts of honeysuckle extract, 0.5-2 parts of rosemary extract, 0.5-2 parts of magnolia bark extract, 0.2-1 parts of chamomile extract and 0.5-2 parts of notoginseng extract.

4. The toothpaste for removing dental plaque according to any one of claims 1 to 3, characterized in that: The foaming agent includes sodium lauroyl sarcosinate and / or cocamidopropyl betaine.

5. The toothpaste for removing dental plaque according to any one of claims 1 to 4, characterized in that: The abrasive comprises calcium carbonate and / or hydrated silica; Preferably, the thickener comprises hydroxypropyl guar gum.

6. The toothpaste for removing dental plaque according to any one of claims 1 to 5, characterized in that: The raw materials for preparing the toothpaste for removing dental plaque also include any one of a moisturizer, a preservative, a chelating agent, a pH regulator or a flavor, or a combination of at least two of them.

7. The toothpaste for removing dental plaque according to claim 6, characterized in that: The raw materials for preparing the toothpaste for removing dental plaque also include, by weight, any one of 40-50 parts of moisturizer, 0.1-0.8 parts of preservative, 0.1-1 parts of chelating agent, 0.1-1 parts of pH regulator or 0.1-1.5 parts of flavor, or a combination of at least two of them.

8. The toothpaste for removing dental plaque according to claim 6 or 7, characterized in that: The pH adjuster includes sodium hydroxide; Preferably, the preservative comprises sodium benzoate; Preferably, the humectant comprises glycerin.

9. The toothpaste for removing dental plaque according to any one of claims 6 to 8, characterized in that: The chelating agent includes EDTA-disodium.

10. The method for preparing a toothpaste for removing dental plaque according to any one of claims 1 to 9, characterized in that: The preparation method comprises: physically mixing the preparation raw materials and defoaming to obtain the product.