Device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension

Abstract

The present invention discloses a device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, which relates to the field of medical instrument testing technology. The device and method include an eyeball environment simulation component and a corneal suture loading component. The corneal suture loading component includes a scraping assembly and a transmission assembly. The eyeball environment simulation component includes an intraocular pressure bubbler, a hydraulic tube, a T-shaped tube and a tear duct. The tear duct is connected to the scraping assembly. The lower end opening on one side of the T-shaped tube is connected to the intraocular pressure bubbler through a hydraulic tube. The lower end opening on the other side of the T-shaped tube is provided with a hydraulic sensor. The present invention adopts the above-mentioned device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension to achieve uniformity of corneal suture, reduce secondary corneal damage caused by uneven suture, reduce the risk of postoperative complications, and provide an experimental basis for the research and development of corneal substitutes.

Description

Technical Field

[0001] The present invention relates to the technical field of medical instrument testing, and in particular to a device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension. Background Art

[0002] Corneal transplant surgery is an important means of treating corneal diseases and improving vision. During surgery, the quality of corneal suture directly affects postoperative recovery and visual outcomes. However, existing corneal suturing technologies have significant limitations. First, monitoring suture tension after corneal suturing has always been an unresolved technical problem. Corneal suture tension has a significant impact on the deformation and stress of corneal tissue, but there is currently no effective means to monitor corneal suture tension in real time, which limits the control of suture quality and the assessment of postoperative recovery.

[0003] In clinical practice, corneal suture tension is primarily determined by the physician's experience and feel, lacking objective quantitative standards and precise monitoring methods. This subjective judgment method has certain limitations and risks. Studies have shown that uneven, shallow, or deep sutures can cause secondary damage to the cornea and generate significant stress concentration at the suture interface, factors that are direct causes of corneal suture failure. Therefore, there is an urgent clinical need for a testing device that can provide standardized and accurate monitoring of corneal suture tension.

[0004] Corneal suturing is a complex and delicate surgical procedure that requires not only the surgeon's exceptional skill but also a deep understanding of the cornea's physical properties and mechanical environment. In the real world, corneal suturing is affected by multiple factors, including eyelid scraping, changes in intraocular pressure, and suture tension. These factors act together on the cornea, influencing the distribution of stress and strain fields. Eyelid scraping can cause additional mechanical stress on the corneal surface. Excessive stress can cause further damage to the sutured cornea or compromise the stability of the suture. Intraocular pressure, a significant factor in the corneal environment, also exerts shear forces on the corneal suture. Suture tension is the force directly acting on the cornea during suturing. It must be precisely balanced—neither too loose to stabilize the wound nor too tight to compress the corneal tissue and compromise subsequent procedures. Understanding these mechanical characteristics is crucial for evaluating the effectiveness of corneal suturing.

[0005] Despite this, there is currently a lack of a test device that can simultaneously simulate eyelid scraping and intraocular pressure loading to evaluate the biomechanical response and suturing effect of the cornea under the influence of these factors. This is a major technical challenge for the development and evaluation of corneal substitutes. Existing studies mostly rely on animal models or cadaver eyes. Although these models provide certain mechanical information, they are still different from the physiological environment of living bodies. Therefore, the development of a system that can simulate eyelid scraping and intraocular pressure loading and monitor corneal suture tension is of great significance for improving corneal suturing technology, developing new corneal substitutes, and evaluating surgical results. In summary, the existing corneal suturing technology and research methods have the following problems:

[0006] It is difficult to accurately simulate corneal eyelid scraping and intraocular pressure changes: The biomechanical properties of the cornea are extremely complex, including its anisotropy, heterogeneity, and dynamic changes related to intraocular pressure, eyelid movement, etc. Existing simulation methods are often unable to fully reproduce this relatively complex corneal service environment, resulting in an inability to accurately simulate the mechanical response of the cornea under actual physiological conditions. For example, although the existing in vitro corneal expansion test can maintain the integrity of the corneal tissue structure, it is unable to accurately simulate the mechanical behavior of the cornea in the actual intraocular environment due to its simplified assumptions about the spherical structure and homogeneity of the cornea, as well as the inability to achieve eyelid scraping and load intraocular pressure.

[0007] 2) Lack of quantitative loading methods for corneal sutures: In corneal transplant surgery, the uniformity and accuracy of sutures are crucial to the success of the operation. However, currently, the clinical practice mainly relies on the doctor's experience and feel to determine the suture tension, and there is a lack of objective quantitative standards and precise monitoring methods. This subjective judgment method has certain limitations and risks, which may lead to secondary damage to the cornea or suture failure. Monitoring the tension after corneal suture is the key to ensuring the success of the operation and preventing complications. However, there is currently a lack of effective technical means to monitor and quantify the corneal suture tension in real time, which limits the accurate evaluation of surgical results and postoperative management.

[0008] 3) Existing measurement methods are unable to evaluate the suturing effect: The recovery process after corneal transplantation is complex, involving the interaction of multiple biomechanical factors, namely corneal eyelid scraping, intraocular pressure changes, and suture tension. The lack of accurate evaluation tools and methods makes it difficult for doctors to effectively monitor and intervene in the postoperative recovery process, and it is also difficult for researchers of corneal substitutes to directly evaluate the biomechanical response of the research subjects under actual physiological conditions. In order to solve these problems, the present invention proposes a corneal suture physical environment simulation and feedback test system, which aims to provide doctors and scientific researchers with a standardized and repeatable testing device by simulating the real corneal suture environment and loading conditions. Through this device, suture tension can be accurately monitored, and corneal service environments such as eyelid scraping and intraocular pressure control can be simulated, providing guidance value for clinical medicine and providing strong technical support for the performance evaluation of cornea and its substitutes. Summary of the Invention

[0009] The purpose of the present invention is to provide a device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, so as to solve the problems in existing corneal suturing technology such as the lack of standardized and accurate monitoring methods, the difficulty in simulating the complex working environment of the cornea, and the lack of an effective testing platform or system to evaluate the performance of corneal substitutes.

[0010] To achieve the above-mentioned objectives, the present invention provides a device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, comprising an eyeball environment simulation component and a cornea suturing loading component, the cornea suturing loading component comprising a scraping assembly and a transmission assembly, the eyeball environment simulation component comprising an intraocular pressure bubbler, a hydraulic tube, a T-shaped tube and a tear duct, the tear duct being connected to the scraping assembly, the lower end opening on one side of the T-shaped tube being connected to the intraocular pressure bubbler through the hydraulic tube, and the lower end opening on the other side of the T-shaped tube being provided with a hydraulic sensor.

[0011] Preferably, the intraocular pressure bubble instrument includes a base, a curved cover is provided on the base, a groove 1 and a groove 2 are respectively provided on the outer side of the curved cover and the inner side of the base, and limit rods are provided in the groove 2 and the groove 1;

[0012] A cornea model is provided on the base, the cornea model is pressed by the curved cover, and is screwed and fixed to the base by a screw cap, and the base and the screw cap are connected by threads.

[0013] Preferably, the scraping assembly includes a rotary motor, the output end of the rotary motor is fixedly connected to the upper part of the connecting rod, the lower end of the connecting rod is connected to a scraping pressure head, and a scraping head with an arc structure is fixedly provided below the scraping pressure head, and the scraping head is adapted to the curvature of the corneal model;

[0014] The connecting rod is configured as a hollow structure, a reserved hole is provided on the scraping head, and the tear duct passes through the connecting rod and the reserved hole and is fixed above the cornea model.

[0015] Preferably, the transmission assembly includes two racks arranged on both sides of the intraocular pressure bubbler, a moving block is provided above each of the two racks, a gear is provided inside the moving block, the gear and the rack are meshed and connected, the center of the gear is fixedly connected to a knob, and the knob extends to the outside of the moving block;

[0016] A support rod is provided above the moving block, a sleeve is provided on the support rod, a support member is provided on the sleeve, a mechanical sensor is provided on the support member, induction rings are provided on both sides of the mechanical sensors, and sutures are connected to the induction rings on both sides.

[0017] Preferably, the T-shaped tube is fixed on the iron frame by a clamp, and the lower end opening position of the T-shaped tube is the same as the height of the reserved hole.

[0018] Preferably, the interior of the T-shaped tube is filled with liquid, and the hydraulic pressure provided is changed by changing the height of the internal liquid, and the hydraulic pressure is set to 0-10 kPa.

[0019] Preferably, a through opening is provided on the base, a hydraulic cavity is provided in the base, and the hydraulic pipe passes through the through opening and communicates with the hydraulic cavity.

[0020] A method for using a device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension comprises the following steps:

[0021] S1. Equipment preparation: Ensure all components are intact, assemble them correctly, calibrate the hydraulic and mechanical sensors, connect the data acquisition system, and start the data acquisition system to warm up to a stable working state;

[0022] S2. Corneal operating environment simulation: Install the corneal model, adjust the eyeball environment simulation components, simulate the tear environment, and monitor environmental parameters;

[0023] S3. Suturing cornea loading: setting suturing parameters, simulating eyelid movement, applying suturing force, and monitoring suturing force.

[0024] Preferably, the specific steps of S2 are as follows:

[0025] S21. Installing the corneal model: Fix the corneal model to be tested on the curved cover of the intraocular pressure bubbler, and adjust the position until the center of the intraocular pressure bubbler and the corneal model are on the same horizontal line to simulate the real eyeball structure;

[0026] S22. Adjust the eyeball environment simulation component: inject liquid into the hydraulic chamber of the intraocular pressure bubbler through the T-tube and adjust the hydraulic pressure to the required intraocular pressure level;

[0027] S23, simulated tear environment: simulated tears are continuously dripped onto the bulging cornea model in the form of water drops through the tear duct to form a uniform tear film environment;

[0028] S24. Monitoring environmental parameters: Monitoring intraocular pressure levels using a hydraulic sensor;

[0029] S25. Adjust corneal curvature: Adjust the curved cover on the outside of the intraocular pressure bubbler as needed to adapt to corneal models with different curvatures so that the cornea is not affected by wrinkles caused by rotating the cover.

[0030] Preferably, the specific steps of S3 are as follows:

[0031] S31. According to the experimental purpose, set the rotation frequency and amplitude of the rotary motor and adjust the height of the scraping head to change the scraping force and frequency provided by the scraping head;

[0032] S32, scraping the cornea model back and forth using the scraping head to simulate the movement of the eyelids during blinking, and simultaneously applying suture tension to the cornea model through the transmission assembly and the mechanical sensor, using the suture to transmit force on the cornea to simulate the application of force during actual suturing;

[0033] S33. Monitor the data output by the mechanical sensor in real time, monitor the suture tension and keep it within a predetermined range, and use a camera to record the corneal morphology in real time, obtain the corneal surface coordinates through calculation, and finally determine the configuration.

[0034] Therefore, the present invention uses the above-mentioned device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, which has the following beneficial effects:

[0035] (1) Quantitative simulation environment: The present invention realizes standardized simulation of the corneal working environment. By precisely controlling the intraocular pressure and tear environment, the present invention provides a quantitative eyeball simulation environment that can be used to perform corresponding tests on corneal materials, and can be used to evaluate the corneal suturing effect and provide corresponding optimization suggestions, thereby improving the repeatability and reliability of the experiment.

[0036] (2) Precise suture tension monitoring: Precise suture tension monitoring technology is an innovative medical monitoring method. This invention is achieved by combining mechanical sensors and precise transmission devices. It can accurately measure and monitor the size and distribution of suture tension, simulating real surgical conditions. Precise suture tension plays a decisive role in wound healing and vision recovery. Therefore, this system helps to study the influence of suture parameters on corneal healing.

[0037] (3) Providing an effective feedback testing platform: The present invention provides an effective testing platform for the research and development of corneal substitutes. The sensors and data acquisition system equipped in the present invention can monitor the intraocular pressure and suture tension in real time. The configuration changes of the cornea before and after the test process can be obtained by camera recording, etc., thereby providing instant feedback to the operator. This can accelerate the evaluation and optimization process of new corneal-related products and shorten the time from laboratory to clinic.

[0038] (4) Obtaining corneal material properties: Based on the simulated corneal service environment, the present invention designs a scraping head to simulate the eyelid, and designs a channel in the scraping head to allow the capillaries that transmit tear fluid to pass through, ensuring that the cornea remains moist during the scraping process. The cornea can be scraped at a specific frequency for a long time to obtain the material property evolution of the tested corneal material under long-term service. The fatigue performance of the corneal model can be tested by scraping action, and its service life can be predicted.

[0039] (5) Reduce animal experiment costs: By providing a testing platform that simulates a real eyeball environment, the present invention utilizes a simplified experimental operation process to obtain test feedback information that cannot be obtained from animal experiments in corneal substitute research, reducing reliance on animal experiments and thus reducing the economic and time costs of related research. It also facilitates in-depth analysis of the mechanical properties of corneal suturing and the causes of postoperative complications. It also helps promote scientific research in the field of corneal suturing and corneal substitutes and promotes the development of new technologies and methods.

[0040] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 A schematic diagram of a portion of an embodiment of a device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension according to the present invention;

[0042] Figure 2 A schematic structural diagram of a scraping assembly of the device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension of the present invention;

[0043] Figure 3 A partially enlarged schematic diagram of suture loading of the device and method for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension of the present invention;

[0044] Figure 4 A schematic diagram of the structure of an intraocular pressure bubbler for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension according to the present invention;

[0045] Figure 5A schematic diagram of the exploded structure of the intraocular pressure bubbler of the present invention for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension;

[0046] Figure numerals: 1. intraocular pressure bubbler; 101. port; 2. hydraulic tube; 3. T-shaped tube; 31. clamp; 4. iron stand; 5. hydraulic sensor; 61. rack; 62. moving block; 63. knob; 64. support rod; 65. sleeve; 66. support member; 7. suture; 8. corneal model; 9. mechanical sensor; 10. rotating motor; 11. connecting rod; 12. scraping head; 121. scraping head; 13. tear duct; 14. screw cap; 15. curved cover; 151. groove one; 16. limit rod; 17. base; 171. groove two. DETAILED DESCRIPTION

[0047] The technical solution of the present invention is further described below with reference to the accompanying drawings and embodiments.

[0048] Unless otherwise defined, the technical or scientific terms used in the present invention shall have the usual meanings understood by persons of ordinary skill in the field to which the present invention belongs. The words "first", "second" and similar terms used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Words such as "include" or "comprise" mean that the elements or objects preceding the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. Words such as "connect" or "connected" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0049] Example

[0050] See also Figure 1-5 The present invention provides a device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, including an eyeball environment simulation component and a cornea suturing loading component. The cornea suturing loading component includes a scraping assembly and a transmission assembly. The eyeball environment simulation component includes an intraocular pressure bubbler 1, a hydraulic tube 2, a T-tube 3 and a tear duct 13. The tear duct 13 is connected to the scraping assembly. The lower end opening on one side of the T-tube 3 is connected to the intraocular pressure bubbler 1 through the hydraulic tube 2. Before the test begins, it is necessary to check the airtightness to prevent liquid leakage. The lower end opening on the other side of the T-tube 3 is provided with a hydraulic sensor 5. The hydraulic sensor 5 is used to measure and display the hydraulic pressure value. The measured hydraulic pressure value is displayed on an external LCD digital display screen with an accuracy of 0.01kPa.

[0051] The T-tube 3 is secured to the iron stand 4 by a clamp 31. The clamp 31 consists of two connected clamps, one clamped to the iron stand 4 and the other clamped to the T-tube 3. By adjusting the height of the clamp on the iron stand 4, the T-tube 3 is adjusted to the appropriate height, aligning the lower opening of the T-tube 3 with the height of the pre-set hole. This ensures that the pressure applied to the corneal model 8 matches the hydraulic pressure value displayed by the hydraulic sensor 5, thereby enabling real-time monitoring of the internal corneal pressure. The design of the iron stand 4 allows for fine-tuning of the height and angle of the T-tube 3 to accommodate different experimental setups and testing requirements.

[0052] The interior of the T-tube 3 is filled with a liquid. The hydraulic pressure is varied by changing the liquid's height, with a range of 0-10 kPa. The liquid is a phosphate buffered saline solution. When the hydraulic pressure sensor 5 is connected to a power source, the phosphate buffered saline solution is injected into the opening 101 of the T-tube 3 as needed. This solution serves as a medium to simulate the aqueous humor environment within the eyeball. The phosphate buffered saline solution is chosen to simulate the physiological environment within the eyeball and ensure the biocompatibility of the corneal model 8 during testing.

[0053] The intraocular pressure bubbler 1 is made of metal and includes a base 17, on which a curved cover 15 is mounted. Grooves 151 and 171 are defined on the outside of the curved cover 15 and the inside of the base 17, respectively. Limit rods 16 are located within grooves 171 and 151, restricting the planar movement of the curved cover 15 to downward movement only. This design prevents wrinkling of the corneal model 8 due to friction caused by twisting. Even when internal pressure increases, the smooth curved surface is maintained, facilitating subsequent corneal loading tests. A corneal model 8 is positioned above the base 17, compressed by the curved cover 15 and secured to the base 17 by a screw cap 14. The base 17 and screw cap 14 are connected by threads.

[0054] A through opening 101 is provided on the base 17, and a hydraulic cavity is provided in the base 17. The hydraulic tube 2 passes through the through opening 101 and is connected to the hydraulic cavity. The hydraulic tube 2 is made of nylon material. The intraocular pressure bubbler 1 is used to simulate the aqueous humor environment in the eyeball. By connecting with the hydraulic tube 2, hydraulic pressure can be applied to the inside, so that the fixed cornea can simulate the bulging state in the real eyeball. Such a design allows the deformation of the cornea to be precisely controlled in the experiment to more realistically reflect the physiological conditions during the operation. The external design is a special curved surface structure used to adapt to the curvature geometry of the corneal model 8, and can prevent the corneal model 8 from being affected by the bulging effect caused by wrinkles caused by the knob fixation.

[0055] The scraping assembly includes a rotary motor 10, a Xiaomi CyberGear servo micromotor. By controlling the frequency and amplitude of rotation via a microprocessor, the movement of a scraping head 12 can be precisely controlled to simulate different eyelid movement patterns. The output end of the rotary motor 10 is fixedly connected to the upper portion of a connecting rod 11, the lower end of which is connected to the scraping head 12. The scraping head 12 is used to reciprocate and scrape the corneal graft to simulate the movement of the eyelid during blinking. A curved scraping head 121 is fixedly mounted below the scraping head 12. This scraping head 121 matches the curvature of the corneal model 8, simulating the scraping action of a real eyelid on the cornea with high fidelity. Both the scraping head 12 and the scraping head 121 are made of rubber. The connecting rod 11 is hollow, with a 1 mm diameter pre-set hole in the scraping head 121. The tear duct 13 passes through the connecting rod 11 and the pre-set hole and is fixed above the corneal model 8. The tear duct 13 is made of PDMS capillaries and is used to continuously drip tears in the form of water drops onto the bulging cornea at a quantitative frequency of 5 μl / min to form a uniform tear film environment. The design of the tear duct 13 takes into account the fluidity and distribution uniformity of tears to simulate the real tear secretion and distribution process.

[0056] The morphological changes of the cornea model 8 during the scraping process can be recorded by an industrial camera. The industrial camera is selected with consideration given to high resolution and high frame rate to capture subtle changes of the cornea model 8 during the scraping process.

[0057] The transmission assembly includes two racks 61 arranged on both sides of the intraocular pressure bubbler 1, and a moving block 62 is arranged above the two racks 61. A gear is arranged in the moving block 62, and the gear and the rack 61 are meshed and connected. The center of the gear is fixedly connected to the knob 63, and the knob 63 extends to the outside of the moving block 62. A support rod 64 is arranged above the moving block 62, and a sleeve 65 is arranged on the support rod 64. A rotating knob is arranged on the sleeve 65. By rotating the rotating knob, the tightness of the sleeve 65 is adjusted so that it can move up and down on the support rod 64 and change the longitudinal position. A support member 66 is arranged on the sleeve 65, and a mechanical sensor 9 is arranged on the support member 66. The mechanical sensor 9 is used to measure the suture force transmitted by the connected suture 7 with an accuracy of 0.001N. Induction rings are arranged on the mechanical sensors 9 on both sides, and sutures are connected to the induction rings on both sides. The transmission assembly is used to achieve free movement in the longitudinal and transverse directions and to be fixed at any position. It is connected to the mechanical sensor 9 to realize the loading of the corneal suture force. When in use, by rotating the knob 63, the gear is driven to move left and right on the rack 61, thereby adjusting the transverse position of the mechanical sensor 9, and by changing the height of the sleeve 65, the longitudinal position of the mechanical sensor 9 is adjusted.

[0058] The method for using the device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension comprises the following steps:

[0059] S1. Equipment preparation: Ensure all components are intact, assemble them correctly, calibrate the hydraulic sensor 5 and the mechanical sensor 9, connect the data acquisition system, and start the data acquisition system to warm up to a stable working state. The specific steps are as follows:

[0060] S11. Assemble the bubbler, hydraulic tube 2, T-tube 3, iron stand 4, hydraulic sensor 5, transmission device, force sensor 9, micromotor, connecting rod 11, scraping head 12, and tear duct 13. Connect all components, ensuring that the hydraulic sensor 5, the bubbler's port 101, and the scraping head 12 are aligned horizontally. After applying hydraulic pressure, the corneal model 8 and the hydraulic sensor 5 display equal data. The scraping head 12 remains stable during pressure application to prevent uneven pressure or equipment vibration from affecting the test.

[0061] S12. Connect the sensor to a data acquisition system, such as a computer or other data logging device, to monitor and record data in real time during the test.

[0062] S2. Corneal operating environment simulation: Install the corneal model 8, adjust the eyeball environment simulation components, simulate the tear environment, and monitor the environmental parameters. The specific steps are as follows:

[0063] S21. Install the cornea model 8: Fix the cornea model 8 to be tested on the curved cover 15 of the tonometer 1, and adjust the position until the tonometer 1 and the center of the cornea model 8 are on the same horizontal line, so as to simulate the real eyeball structure.

[0064] S22. Adjust the eyeball environment simulation component: inject liquid into the hydraulic chamber of the intraocular pressure bubbler 1 through the T-tube 3, and adjust the hydraulic pressure to the required intraocular pressure level.

[0065] S23 , simulating tear environment: continuously dripping simulated tears in the form of water drops onto the bulging cornea model 8 through the tear duct 13 to form a uniform tear film environment.

[0066] S24. Monitoring environmental parameters: using the hydraulic pressure sensor 5 to monitor the intraocular pressure level.

[0067] S25 , adjusting corneal curvature: as needed, adjust the curved cover 15 outside the intraocular pressure bubbler 1 to adapt to corneal models 8 with different curvatures so that the cornea is not affected by wrinkles caused by rotating the cover 14 .

[0068] S3. Suturing cornea loading: Set suturing parameters, simulate eyelid movement, apply suturing force, and monitor suturing force. The specific steps are as follows:

[0069] S31. According to the experimental purpose, the rotation frequency and amplitude of the rotary motor 10 are set, and the height of the scraping head 12 is adjusted to change the scraping force and frequency provided by the scraping head 12.

[0070] S32. Use the scraping head 12 to scrape the cornea model 8 back and forth to simulate the movement of the eyelids when blinking. At the same time, apply tension to the cornea model 8 through the transmission component and the mechanical sensor 9, and use the suture 7 to transmit the force on the cornea to simulate the actual suturing process.

[0071] S33, monitor the data output by the mechanical sensor 9 in real time, monitor the tension of the suture 7 and make the tension of the suture 7 within a predetermined range, use a camera to record the corneal morphology in real time, obtain the corneal surface coordinates through calculation, and finally determine the configuration.

[0072] Therefore, the present invention adopts the above-mentioned device and method for simulating eyelid scraping and intraocular pressure loading and monitoring the tension of suture 7 to achieve uniformity of corneal suturing, reduce secondary damage to the cornea caused by uneven suturing, reduce the risk of postoperative complications, and provide an experimental basis for the research and development of corneal substitutes.

[0073] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the same. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solutions of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension, characterized by: The device comprises an eyeball environment simulation component and a cornea suturing loading component, wherein the cornea suturing loading component comprises a scraping assembly and a transmission assembly, wherein the eyeball environment simulation component comprises an intraocular pressure bubbler, a hydraulic tube, a T-shaped tube and a tear duct, wherein the tear duct is connected to the scraping assembly, wherein the lower end opening on one side of the T-shaped tube is connected to the intraocular pressure bubbler via the hydraulic tube, and the lower end opening on the other side of the T-shaped tube is provided with a hydraulic pressure sensor, wherein the interior of the T-shaped tube is filled with liquid, and the hydraulic pressure provided is changed by changing the height of the internal liquid, and the hydraulic pressure is set to 0-10kPa; The intraocular pressure bubble instrument includes a base, a curved cover is provided on the base, a groove 1 and a groove 2 are respectively provided on the outer side of the curved cover and the inner side of the base, and limit rods are provided in the groove 2 and the groove 1; a cornea model is provided on the base, the cornea model is pressed by the curved cover and is screwed to the base by a screw cap, the base and the screw cap are connected by threads, a through opening is provided on the base, a hydraulic chamber is provided in the base, and the hydraulic pipe passes through the through opening and is connected to the hydraulic chamber; The scraping assembly includes a rotary motor, the output end of which is fixedly connected to the upper part of a connecting rod, the lower end of which is connected to a scraping head, a scraping head with an arc-shaped structure fixedly provided below the scraping head, the scraping head being adapted to the curvature of the cornea model, and the height of the scraping head being adjusted to change the scraping force and frequency provided by the scraping head; the connecting rod is configured as a hollow structure, the scraping head being provided with a reserved hole, the tear duct passing through the connecting rod and the reserved hole and being fixed above the cornea model, the tear duct being made of a PDMS capillary tube and being used to continuously drip tears in the form of water drops onto the bulging cornea model at a quantitative frequency of 5 μl / min; The transmission assembly includes two racks arranged on both sides of the intraocular pressure bubble meter, and a moving block is arranged above the two racks. A gear is arranged in the moving block, and the gear and the rack are meshed and connected. The center of the gear is fixedly connected to the knob, and the knob extends to the outside of the moving block; a support rod is arranged above the moving block, and a sleeve is arranged on the support rod. A rotating knob is provided on the sleeve, and the tightness of the sleeve is adjusted by rotating the rotating knob so that it can move up and down on the support rod and change the longitudinal position. A support member is provided on the sleeve, and a mechanical sensor is provided on the support member. Induction rings are provided on the mechanical sensors on both sides, and sutures are connected to the induction rings on both sides, and the sutures are used to transmit the force on the cornea to simulate the actual suturing process.

2. The device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension according to claim 1, characterized in that: The T-shaped tube is fixed on the iron frame by a clamp, and the lower end opening position of the T-shaped tube is at the same height as the reserved hole.

3. A method for using the device for simulating eyelid scraping and intraocular pressure loading and monitoring suture tension as described in claim 2, characterized in that: The following steps are involved: S1. Equipment preparation: Ensure that all components are intact, assemble each component correctly, calibrate the hydraulic sensor and mechanical sensor, connect the data acquisition system, start the data acquisition system and preheat it to a stable working state; S2. Corneal service environment simulation: Install the corneal model, adjust the eyeball environment simulation components, simulate the tear environment, and monitor the environmental parameters; S3. Suturing corneal loading: Set suturing parameters, simulate eyelid movement, apply suturing force, and monitor the suturing force.

4. The method of simulating eyelid scraping and intraocular pressure loading and monitoring suture tension according to claim 3, characterized in that: The specific steps of S2 are as follows: S21. Installing the corneal model: Fixing the corneal model to be tested on the curved cover of the tonometer, and adjusting the position until the tonometer and the center of the corneal model are on the same horizontal line to simulate the real eyeball structure; S22. Adjusting the eyeball environment simulation component: Injecting liquid into the hydraulic chamber of the tonometer through the T-tube, and adjusting the hydraulic pressure to the required intraocular pressure level; S23. Simulating the tear environment: Continuously dripping simulated tears in the form of water droplets onto the bulging corneal model through the tear duct to form a uniform tear film environment; S24. Monitoring environmental parameters: Using a hydraulic sensor to monitor the intraocular pressure level; S25. Adjusting the corneal curvature: Adjusting the curved cover on the outside of the tonometer as needed to adapt to corneal models with different curvatures so that the cornea is not affected by wrinkles caused by rotating the cover.

5. The method of simulating eyelid scraping and intraocular pressure loading and monitoring suture tension according to claim 4, characterized in that: The specific steps of S3 are as follows: S31. According to the experimental purpose, the rotation frequency and amplitude of the rotating motor are set, and the height of the scraping head is adjusted to change the scraping force and frequency provided by the scraping head; S32. The corneal model is scraped back and forth using the scraping head to simulate the movement of the eyelids during blinking, and at the same time, suture tension is applied to the corneal model through the transmission component and the mechanical sensor, and the force applied on the cornea during the actual suturing process is transmitted through the suture; S33. The data output by the mechanical sensor is monitored in real time, the suture tension is monitored and the suture tension is kept within a predetermined range, and the corneal morphology is recorded in real time using a camera, the corneal surface coordinates are obtained by calculation, and finally the configuration is determined.

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