Relieving nutritional cream suitable for skin of diabetic patient

Abstract

The invention belongs to the field of daily necessities, and particularly relates to a soothing nutritional cream suitable for the skin of a diabetic patient, which takes ceramide NP, 4-tert-butyl cyclohexanol, a cynanchum atratum extract, bisabolol and a robinia pseudoacacia flower extract as main active ingredients of a repair cream, and is matched with a humectant, an emulsifier, an emollient, an antioxidant, an oil phase and a water phase matrix. The obvious effects of relieving the phenomena of decrustation, chap and the like caused by dry skin of hands and feet of the diabetic patient, strengthening the natural barrier function of the skin and relieving the symptom of skin itch are synergistically realized.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities, and in particular relates to a soothing and nourishing cream suitable for the skin of diabetic patients. Background Art

[0002] When blood sugar in diabetic patients rises, it can cause an inexplicable itching of the skin. This itching usually occurs in the hands and feet, causing patients to want to scratch their skin all the time, which causes great trouble in their lives. Studies have shown that pruritus is the second most common skin symptom of diabetes. High blood sugar can cause inflammatory substances to be produced in the body, which can damage nerve endings over time and cause frequent itching of the skin. According to statistics, about 20% of diabetic patients have experienced skin itching symptoms of varying degrees of severity. The severity of the itching symptoms is basically positively correlated with the size of the blood sugar value. The higher the blood sugar, the more severe the itching. The skin itching of diabetic patients is very stubborn, and the itching of the hands and feet brings many inconveniences to the daily life and daily social life of diabetic patients. In addition, diabetic patients may experience peripheral neuropathy, which can cause abnormal sensations such as numbness, tingling, pain or burning in the skin of the hands and feet.

[0003] Dry skin is also a typical skin symptom of diabetic patients. In fact, many reasons can cause dry skin, but diabetic patients have symptoms of dry skin because high blood sugar can cause frequent urination and skin dehydration, which in turn leads to xerosis. Dry skin in diabetic patients is often accompanied by fine cracks and peeling, and dryness will also aggravate the symptoms of skin itching. Dryness symptoms will be more severe in the cold winter, because the humidity of the air will decrease as the temperature drops, causing the skin to lose moisture and dry out more easily. Moreover, dry skin caused by diabetes usually occurs in the elderly, because the sweat glands and sebaceous glands of the elderly degenerate, and the skin will be more susceptible to dehydration and dryness.

[0004] Therefore, providing a soothing nourishing cream suitable for the skin of diabetic patients to repair the skin of hands and feet and relieve the symptoms of skin itching is an important issue that needs to be solved urgently. Summary of the invention

[0005] The invention belongs to the technical field of daily necessities and provides a soothing and nourishing cream suitable for the skin of diabetic patients.

[0006] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, comprising a water phase, an oil phase, and a repairing composition;

[0007] The aqueous phase includes purified water and a moisturizer;

[0008] The oil phase includes oil, emulsifier, emollient and antioxidant;

[0009] The repair composition comprises ceramide NP, 4-tert-butyl cyclohexanol, iris odoratus extract, bisabolol, and acacia flower extract.

[0010] The moisturizing agent is selected from at least one of glycerin, 1,2-pentanediol, panthenol, sodium hyaluronate, chlorella extract, and hydrolyzed soy protein;

[0011] The oil is selected from at least one of coconut oil, moringa seed oil, avocado butter, caprylic / capric triglyceride, dimethicone, mineral oil, petrolatum, and cetearyl alcohol;

[0012] The emulsifier is selected from at least one of steareth-2, steareth-21, cetearyl glucoside and glyceryl monostearate;

[0013] The emollient is selected from at least one of coconut oil alcohol-caprylate / caprate, C13-14 isoparaffin, neopentyl glycol diheptanoate, and caprylyl polymethicone;

[0014] The antioxidant is selected from cashew seed oil, vitamin E or both.

[0015] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, which comprises, by mass percentage, a water phase, 31.7-61.2% of an oil phase, and 0.81-11.7% of a repairing composition;

[0016] The aqueous phase includes the balance of purified water and 14.7-29.1% of a moisturizer;

[0017] The oil phase comprises 25.0-44.5% of oil, 1.4-3.2% of emulsifier, 5.0-13.0% of emollient, and 0.3-0.5% of antioxidant;

[0018] The repair composition comprises 0.5-10% ceramide NP, 0.1-0.5% 4-tert-butyl cyclohexanol, 0.1-0.5% white violet extract, 0.1-0.5% bisabolol, and 0.01-0.2% acacia flower extract;

[0019] The moisturizing agent is 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soy protein;

[0020] The oil is 2.5-5.0% coconut oil, 7.0-10.0% avocado butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol;

[0021] The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21;

[0022] The emollient is 1.5-4.0% coconut oil alcohol-caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate;

[0023] The antioxidant is 0.1% cashew seed oil and 0.2-0.4% vitamin E.

[0024] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, which comprises, by mass percentage, a water phase, 31.7-61.2% of an oil phase, and 3.5-6.15% of a repairing composition;

[0025] The aqueous phase includes the balance of purified water and 14.7-29.1% of a moisturizer;

[0026] The oil phase comprises 25.0-44.5% of oil, 1.4-3.2% of emulsifier, 5.0-13.0% of emollient, and 0.3-0.5% of antioxidant;

[0027] The repair composition comprises 3.0-5.0% ceramide NP, 0.1-0.3% 4-tert-butyl cyclohexanol, 0.15-0.35% white violet extract, 0.2-0.35% bisabolol, and 0.05-0.15% acacia flower extract;

[0028] The moisturizing agent is 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soy protein;

[0029] The oil is 2.5-5.0% coconut oil, 7.0-10.0% avocado butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol;

[0030] The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21;

[0031] The emollient is 1.5-4.0% coconut oil alcohol-caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate;

[0032] The antioxidant is 0.1% cashew seed oil and 0.2-0.4% vitamin E.

[0033] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, which comprises, by mass percentage, a water phase, 31.8-61.1% of an oil phase, and 4.85% of a repairing composition;

[0034] The aqueous phase includes the balance of purified water and 14.7-29.1% of a moisturizer;

[0035] The oil phase includes 25.0-44.5% oil, 1.4-3.2% emulsifier, 5.0-13.0% emollient, and 0.4% antioxidant;

[0036] The repair composition includes 4.0% ceramide NP, 0.2% 4-tert-butyl cyclohexanol, 0.25% white osmanthus extract, 0.3% bisabolol, and 0.1% acacia flower extract;

[0037] The moisturizing agent is 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soy protein;

[0038] The oil is 2.5-5.0% coconut oil, 7.0-10.0% avocado butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol;

[0039] The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21;

[0040] The emollient is 1.5-4.0% coconut oil alcohol-caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate;

[0041] The antioxidants are 0.1% cashew seed oil and 0.3% vitamin E.

[0042] The present invention provides application of the soothing nourishing cream suitable for the skin of diabetic patients in improving the itching of the skin of diabetic patients and / or repairing the skin of the hands and feet of diabetic patients.

[0043] The present invention provides a method for preparing a soothing and nourishing cream suitable for the skin of diabetic patients, comprising the following preparation steps:

[0044] S1, water phase preparation process: heat purified water to 50-65°C, slowly add moisturizer while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 50-65°C, and set aside;

[0045] S2, oil phase preparation process: heat the oil to 70-80°C, add the emulsifier, emollient and antioxidant in sequence while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 70-80°C, and set aside;

[0046] S3, primary emulsification process: slowly add the water phase into the oil phase, stirring while adding, until a uniform emulsion is formed, and use a homogenizer to homogenize to improve the emulsification effect;

[0047] S4, repair composition addition process: lower the temperature to 30-40°C to prevent high temperature from destroying the active ingredients in the repair composition, and add 4-tert-butyl cyclohexanol, bisabolol, ceramide NP, white osmanthus extract, and acacia flower extract in sequence while maintaining stirring until they are completely dissolved and dispersed;

[0048] S5, cooling and packaging process: continue stirring, cool the mixture to room temperature, stop stirring, let it stand for 0.5 to 2 hours to obtain a soothing nourishing cream suitable for the skin of diabetic patients, and aseptically package the prepared soothing nourishing cream.

[0049] The aseptic packaging can be made of aluminum tubes, plastic bottles, or glass bottles.

[0050] Compared with the prior art, the present invention has the following beneficial effects:

[0051] (1) The skin moisture content test confirms that the soothing and nourishing cream suitable for the skin of diabetic patients of the present invention has good moisturizing ability and can effectively alleviate the phenomena of peeling, chapped skin, etc. caused by dry skin;

[0052] (2) The skin moisture loss test confirms that the soothing and nourishing cream suitable for the skin of diabetic patients of the present invention has good repairing ability, can strengthen the natural barrier function of the skin, enhance the skin's resistance to external stimuli, and maintain the healthy and stable state of the skin;

[0053] (3) Subjective evaluation confirmed that the soothing nourishing cream for diabetic patients' skin of the present invention effectively and significantly improved the skin roughness phenomenon and increased the skin smoothness. The added anti-inflammatory soothing ingredients, 4-tert-butyl cyclohexanol, white osmanthus extract, and bisabolol can effectively alleviate the symptoms of skin itching. DETAILED DESCRIPTION

[0054] In order to more fully understand the technical content of the present invention, the present invention will be further introduced and illustrated in conjunction with specific embodiments below; obviously, the embodiments described below are only part of the embodiments of the present invention, rather than all of the embodiments; based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0055] The components involved in the present invention are all purchased from commercial raw materials on the market.

[0056] The invention provides a repairing composition suitable for the hands and feet of diabetic patients, comprising ceramide NP, 4-tert-butyl cyclohexanol, iris sibiricum extract, bisabolol and acacia flower extract.

[0057] The present invention provides an application of a repairing composition suitable for the hands and feet of diabetic patients in preparing a soothing and nourishing cream suitable for the skin of diabetic patients, wherein the mass percentage of the repairing composition in the soothing and nourishing cream is 0.81-11.7%;

[0058] The mass percentages of the ingredients in the repair composition suitable for the hands and feet of diabetic patients in the soothing nourishing cream are as follows: 0.5-10% ceramide NP, 0.1-0.5% 4-tert-butyl cyclohexanol, 0.1-0.5% white osmanthus extract, 0.1-0.5% bisabolol, and 0.01-0.2% acacia flower extract.

[0059] The mass percentages of the ingredients in the soothing nourishing cream in the repair composition suitable for the hands and feet of diabetic patients are as follows: 3.0-5.0% ceramide NP, 0.1-0.3% 4-tert-butyl cyclohexanol, 0.15-0.35% white osmanthus extract, 0.2-0.35% bisabolol, and 0.05-0.15% acacia flower extract.

[0060] The mass percentages of the ingredients in the repair composition for the hands and feet of diabetic patients in the soothing nourishing cream are as follows: 4.0% ceramide NP, 0.2% 4-tert-butyl cyclohexanol, 0.25% white osmanthus extract, 0.3% bisabolol, and 0.1% acacia flower extract.

[0061] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, comprising a water phase, an oil phase, and a repairing composition;

[0062] The aqueous phase includes purified water and a humectant;

[0063] The oil phase includes oils, emulsifiers, emollients, and antioxidants;

[0064] The repairing composition includes ceramide NP, 4-tert-butylcyclohexanol, white osmanthus extract, bisabolol, and acacia flower extract.

[0065] The moisturizer is selected from one or more of glycerin, 1,2-pentanediol, panthenol, sodium hyaluronate, chlorella extract, and hydrolyzed soy protein;

[0066] The oil is selected from one or more of coconut oil, moringa seed oil, shea butter, caprylic / capric triglyceride, dimethicone, mineral oil, petrolatum, and cetearyl alcohol;

[0067] The emulsifier is selected from one or more of steareth-2, steareth-21, cetearyl glucoside, and glyceryl monostearate;

[0068] The emollient is selected from one or more of coconut oil alcohol-caprylate / caprate, C13-14 isoparaffin, neopentyl glycol diheptanoate, and caprylyl polymethicone;

[0069] The antioxidant is selected from cashew seed oil, vitamin E or both.

[0070] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, which comprises, by mass percentage, a water phase, 31.7-61.2% of an oil phase, and 0.81-11.7% of a repairing composition;

[0071] The aqueous phase includes the balance of purified water and 14.7-29.1% of a humectant;

[0072] The oil phase includes 25.0-44.5% oil, 1.4-3.2% emulsifier, 5.0-13.0% emollient, and 0.3-0.5% antioxidant;

[0073] The repair composition includes 0.5-10% ceramide NP, 0.1-0.5% 4-tert-butyl cyclohexanol, 0.1-0.5% white osmanthus extract, 0.1-0.5% bisabolol, and 0.01-0.2% acacia flower extract;

[0074] The moisturizing agent is 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soy protein;

[0075] The oil is 2.5-5.0% coconut oil, 7.0-10.0% shea butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol;

[0076] The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21;

[0077] The emollients are 1.5-4.0% coconut oil alcohol caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate;

[0078] The antioxidants are 0.1% cashew seed oil and 0.2-0.4% vitamin E.

[0079] The present invention provides a soothing and nourishing cream suitable for the skin of diabetic patients, which comprises, by mass percentage, a water phase, 31.7-61.2% of an oil phase, and 3.5-6.15% of a repairing composition;

[0080] The aqueous phase includes the balance of purified water and 14.7-29.1% of a humectant;

[0081] The oil phase includes 25.0-44.5% oil, 1.4-3.2% emulsifier, 5.0-13.0% emollient, and 0.3-0.5% antioxidant;

[0082] The repair composition comprises 3.0-5.0% ceramide NP, 0.1-0.3% 4-tert-butyl cyclohexanol, 0.15-0.35% white osmanthus extract, 0.2-0.35% bisabolol, and 0.05-0.15% acacia flower extract;

[0083] The moisturizing agent is 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soy protein;

[0084] The oil is 2.5-5.0% coconut oil, 7.0-10.0% shea butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol;

[0085] The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21;

[0086] The emollients are 1.5-4.0% coconut oil alcohol caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate;

[0087] The antioxidants are 0.1% cashew seed oil and 0.2-0.4% vitamin E.

[0088] The present invention provides application of the soothing nourishing cream suitable for the skin of diabetic patients in improving the itching of the skin of diabetic patients and / or repairing the skin of the hands and feet of diabetic patients.

[0089] The present invention provides a method for preparing a soothing and nourishing cream suitable for the skin of diabetic patients, comprising the following preparation steps:

[0090] S1, water phase preparation process: heat purified water to 50-65°C, slowly add moisturizer while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 50-65°C, and set aside;

[0091] S2, oil phase preparation process: heat the oil to 70-80°C, add the emulsifier, emollient and antioxidant in sequence while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 70-80°C, and set aside;

[0092] S3, primary emulsification process: slowly add the water phase into the oil phase, stirring while adding, until a uniform emulsion is formed, and use a homogenizer to homogenize to improve the emulsification effect;

[0093] S4, repair composition addition process: lower the temperature to 30-40°C to prevent high temperature from destroying the active ingredients in the repair composition, and add 4-tert-butyl cyclohexanol, bisabolol, ceramide NP, white osmanthus extract, and acacia flower extract in sequence while maintaining stirring until they are completely dissolved and dispersed;

[0094] S5, cooling and packaging process: continue stirring, cool the mixture to room temperature, stop stirring, let it stand for 0.5 to 2 hours to obtain a soothing nourishing cream suitable for the skin of diabetic patients, and aseptically package the prepared soothing nourishing cream.

[0095] Aseptic packaging can be made from aluminum tubes, plastic bottles, and glass bottles.

[0096] Examples and Comparative Examples

[0097] 1. The formula (wt%) is shown in Table 1.

[0098] Table 1 Formula table of embodiments and comparative examples (wt%)

[0099]

[0100]

[0101] The preparation method comprises the following steps:

[0102] S1, water phase preparation process: heat purified water to 55°C, slowly add the moisturizer while stirring, stir evenly until it is completely dissolved, continue stirring, maintain the temperature at 55°C, and set aside;

[0103] S2, oil phase preparation process: heat the oil to 75°C, add the emulsifier, emollient and antioxidant in sequence while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 75°C, and set aside;

[0104] S3, primary emulsification process: slowly add the water phase into the oil phase, stirring while adding, until a uniform emulsion is formed, and use a homogenizer to homogenize to improve the emulsification effect;

[0105] S4, repair composition addition process: lower the temperature to 35°C to prevent high temperature from destroying the active ingredients in the repair composition, and add 4-tert-butyl cyclohexanol, bisabolol, ceramide NP, white osmanthus extract, and acacia flower extract in sequence while maintaining stirring until they are completely dissolved and dispersed;

[0106] S5, cooling and packaging process: continue stirring, cool the mixture to room temperature, stop stirring, let it stand for 1 hour to obtain a soothing nourishing cream suitable for the skin of diabetic patients, and aseptically package the prepared soothing nourishing cream in an aluminum tube.

[0107] 2. Skin moisture content test

[0108] Recruit a number of test volunteers, requirements: 45-60 years old, type 2 diabetes patients, dry skin on hands and feet (rough skin on the back of hands and heels, slight peeling or slight chapped skin, etc.), and sign the informed consent form before testing. Test conditions: ambient temperature 20 ° C, relative humidity 40% to 60%. Test instrument: Corneometer CM 825. Before the test, volunteers need to wash their hands and feet with clean water, and sit quietly for 30 minutes under the test conditions after washing. Mark the test area on the symmetrical parts of the back of the hands and heels of the volunteers, and use the instrument to measure the blank value of the test area. Each area is fixedly measured at 3 points in a certain order, and the results are averaged and recorded as MMV0. Then apply about 0.3g of the soothing and nourishing cream of Example 1-2 or Comparative Example 1-3 to the test area, and use the instrument again after 4h to measure the skin moisture value of the test area. Each area is fixedly measured at 3 points in the same order, and the results are averaged and recorded as MMV. The results are shown in Table 2.

[0109] The formula for calculating the change in skin moisture content is as follows:

[0110] Skin moisture content change rate % = (MMV-MMV0) / MMV0*100%.

[0111] 3. Skin moisture loss test

[0112] Recruit a number of test volunteers, requirements: 45-60 years old, type 2 diabetes patients, dry skin on hands and feet (rough skin on the back of hands and heels, slight peeling or slight cracking, etc.), and sign an informed consent form before conducting the test. Test instrument: Tewameter TM 300. Test site: Symmetrical area of ​​the back of hands and heels. Volunteers apply the soothing and nourishing cream of Example 1-2 or Comparative Example 1-3 to both hands in the morning, noon and evening every day, and apply the soothing and nourishing cream of Example 1-2 or Comparative Example 1-3 to both feet in the morning and evening every day for 3 consecutive weeks. During the test, avoid using products that affect the test results and avoid activities that affect the test results. Before and after the test, use the Tewameter TM 300 instrument to measure the skin water loss (TEWL) value of the test area of ​​hands and feet. The unit of TEWL is g / hm 2 , calculate the change rate of skin water loss before and after using moisturizer. The results are shown in Table 2.

[0113] The formula for calculating the rate of change of skin water loss is as follows:

[0114] Skin water loss change rate % = (TEWL 测试后 -TEWL 测试前 ) / TEWL 测试前 *100%.

[0115] Table 2 Skin moisture content test

[0116]

[0117] The skin moisture content test can directly reflect the moisturizing effect of the product, and the skin moisture loss test is an important indicator for evaluating the state of the skin barrier function. The soothing nourishing cream of the present invention has good moisturizing ability, and contains rich moisturizing ingredients, which can keep the skin of the hands and feet of diabetic patients in a relatively moisturized state, and alleviate the peeling, chapped and other phenomena caused by dry skin. At the same time, the soothing nourishing cream of the present invention has good repair ability, can strengthen the natural barrier function of the skin, enhance the skin's resistance to external stimuli, and maintain the healthy and stable state of the skin. The test results show that the soothing nourishing cream of Example 1-2 has a more significant improvement effect on the test effect of the back of the hand and the heel than that of Comparative Example 1-3.

[0118] 4. Volunteers’ subjective evaluation

[0119] After using the soothing and nourishing cream of Examples 1-2 or Comparative Examples 1-3 for 3 consecutive weeks, the volunteers who performed the skin moisture loss test subjectively evaluated the smoothness and roughness improvement of the skin on the hands and feet, and the improvement of itching. The subjective evaluation was scored on a scale of 1-5, with the higher the score, the better the skin condition. The results are shown in Table 3.

[0120] Table 3 Statistics of volunteers' subjective evaluation

[0121] Smoothness Rough Improvement Improved itching Example 1 3.6 4.2 4.6 Example 2 3.4 4.4 4.5 Comparative Example 1 3.1 3.9 3.8 Comparative Example 2 2.8 3.5 2.4 Comparative Example 3 3.0 3.6 2.7

[0122] The subjective evaluation of volunteers confirmed that the soothing and nourishing cream of the present invention has a significant effect on the repair of the skin on the hands and feet of diabetic patients. The soothing and nourishing cream of the present invention replenishes the nutrients and moisturizing ingredients required by the skin, repairs the damaged skin barrier, and enhances the skin's moisturizing ability, thereby significantly improving the rough skin phenomenon and increasing the smoothness of the skin. At the same time, the anti-inflammatory soothing ingredients, 4-tert-butyl cyclohexanol, white violet extract, and bisabolol added to the soothing and nourishing cream of the present invention can effectively inhibit skin inflammatory reactions, relieve itching discomfort caused by dry skin, environmental irritation, etc., and reduce skin itching symptoms. The test results show that the soothing and nourishing cream of Example 1-2 has a more significant improvement effect than Comparative Examples 1-3.

[0123] The above contents are further detailed descriptions of the present invention in combination with specific preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as falling within the protection scope of the present invention.

Claims

1. A soothing and nourishing cream suitable for the skin of diabetic patients, comprising, by mass percentage, a water phase, 31.7-61.2% of an oil phase, and 0.81-11.7% of a repairing composition.

2. The soothing and nourishing cream according to claim 1, characterized in that: The aqueous phase includes the balance of purified water and 14.7-29.1% of a moisturizer; The oil phase comprises 25.0-44.5% of oil, 1.4-3.2% of emulsifier, 5.0-13.0% of emollient, and 0.3-0.5% of antioxidant; The repair composition comprises 0.5-10% ceramide NP, 0.1-0.5% 4-tert-butyl cyclohexanol, 0.1-0.5% white osmanthus extract, 0.1-0.5% bisabolol, and 0.01-0.2% acacia flower extract.

3. The soothing and nourishing cream according to claim 2, characterized in that: The moisturizing agent is selected from at least one of glycerin, 1,2-pentanediol, panthenol, sodium hyaluronate, chlorella extract, and hydrolyzed soy protein.

4. The soothing nourishing cream according to claim 2, characterized in that: The oil is selected from at least one of coconut oil, moringa seed oil, avocado butter, caprylic / capric triglyceride, dimethicone, mineral oil, petrolatum, and cetearyl alcohol; The emulsifier is selected from at least one of steareth-2, steareth-21, cetearyl glucoside and glyceryl monostearate; The emollient is selected from at least one of coconut oil alcohol-caprylate / caprate, C13-14 isoparaffin, neopentyl glycol diheptanoate, and caprylyl polymethicone.

5. The soothing and nourishing cream according to claim 2, characterized in that: The antioxidant is selected from cashew seed oil, vitamin E or both.

6. The soothing and nourishing cream according to claim 3, characterized in that: The moisturizing agent comprises 7.0-10.0% glycerin, 3.0-5.0% 1,2-pentanediol, 1.0-4.0% panthenol, 0.2-0.6% sodium hyaluronate, 1.5-4.0% chlorella extract, and 2.0-5.5% hydrolyzed soybean protein.

7. The soothing and nourishing cream according to claim 4, characterized in that: The oil is 2.5-5.0% coconut oil, 7.0-10.0% avocado butter, 6.0-9.0% caprylic / capric triglyceride, 3.0-7.5% dimethicone, 5.0-8.0% petrolatum, and 1.5-5.0% cetearyl alcohol; The emulsifier is 0.6-1.5% steareth-2 and 0.8-1.7% steareth-21; The emollient is 1.5-4.0% coconut oil alcohol-caprylate / caprate, 2.5-5.5% C13-14 isoparaffin, and 1.0-3.5% neopentyl glycol diheptanoate.

8. The soothing and nourishing cream according to claim 5, characterized in that: The antioxidant is 0.1% cashew seed oil and 0.2-0.4% vitamin E.

9. Use of the soothing and nourishing cream suitable for the skin of diabetic patients as claimed in any one of claims 1 to 8 in improving itchy skin of diabetic patients and / or repairing the skin of hands and feet of diabetic patients.

10. The method for preparing the soothing and nourishing cream suitable for the skin of diabetic patients according to any one of claims 1 to 8, comprising the following preparation steps: S1, water phase preparation process: heat purified water to 50-65°C, slowly add moisturizer while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 50-65°C, and set aside; S2, oil phase preparation process: heat the oil to 70-80°C, add the emulsifier, emollient and antioxidant in sequence while stirring, stir evenly until completely dissolved, continue stirring, maintain the temperature at 70-80°C, and set aside; S3, primary emulsification process: slowly add the water phase into the oil phase, stirring while adding, until a uniform emulsion is formed, and use a homogenizer to homogenize to improve the emulsification effect; S4, repair composition addition process: lower the temperature to 30-40°C to prevent high temperature from destroying the active ingredients in the repair composition, and add 4-tert-butyl cyclohexanol, bisabolol, ceramide NP, white osmanthus extract, and acacia flower extract in sequence while maintaining stirring until they are completely dissolved and dispersed; S5, cooling and packaging process: continue stirring, cool the mixture to room temperature, stop stirring, let it stand for 0.5 to 2 hours to obtain a soothing nourishing cream suitable for the skin of diabetic patients, and aseptically package the prepared soothing nourishing cream.

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