Application of 1-methyl nicotinamide in preparation of medicine for treating necrotizing enterocolitis

By using 1-methylnicotinamide in the treatment of neonatal necrotizing enterocolitis (NEC), the problems of surgical risks and lack of drug treatment options in the prior art were solved, and the effects of significantly reducing mortality and tissue damage and improving intestinal function and flora structure were achieved.

CN119837874AInactive Publication Date: 2025-04-18CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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Patent Information

Application Number
CN202510122182.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-26
Publication Date
2025-04-18
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art relies on surgery in the treatment of neonatal necrotizing enterocolitis (NEC), with surgical risks such as postoperative infection, intestinal fistula and short bowel syndrome, and lacks effective drug treatment options.

Method used

1-methylnicotinamide is used as a drug ingredient, and the effective dose is 80~120mg/kg/day through oral liquid or injection solution, which is used to treat necrotic enterocolitis.

Benefits of technology

1-methylnicotinamide significantly reduces the mortality and histopathological damage in NEC rats, reduces the concentration of TNF-α and IL-1β in intestinal tissues, improves intestinal barrier function, inhibits the activation of TLR4 and NF-κB pathways, improves the structure of the intestinal flora, and effectively treats necrotic enterocolitis.

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Abstract

The invention discloses application of 1-methyl nicotinamide in preparation of a medicine for treating necrotizing enterocolitis, and belongs to the technical field of medicines. According to the application of the 1-methyl nicotinamide in preparation of the medicine for treating the necrotizing enterocolitis, the medicine contains the 1-methyl nicotinamide with an effective dose, and the 1-methyl nicotinamide has a good effect when being used for treating the necrotizing enterocolitis.
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Citation Information

Patent Citations

  • Compositions and Methods for Treating Necrotizing Enterocolitis

    US20090105188A1

  • Compositions and methods for diagnosing and treating inflammatory conditions

    US20240350456A1

Cited By

  • Application of nicotinic acid in preparation of medicine for preventing and treating neonatal necrotizing enterocolitis

    CN121818639A