Nasal administration device for small animals

Abstract

The invention relates to a nasal administration device for small animals, which comprises an injection mechanism, and the injection mechanism comprises a needle; the injection mechanism is arranged on the shell, and the injection mechanism can rotate relative to the shell around the axial direction of the needle head; the sleeve is arranged at the front end of the shell, and the periphery of the needle head is movably sleeved with the sleeve; and the position measuring module is arranged at the front end of the sleeve. The medicine can be safely and accurately delivered into the nasal cavity of the mouse.

Description

Technical Field

[0001] The invention relates to the technical field of drug delivery equipment, and in particular to a nasal drug delivery device for small animals. Background Art

[0002] When delivering drugs to the mouse nose-brain, due to the narrow nasal cavity of mice, the structure inside the nasal cavity cannot be visualized during drug delivery. If the insertion is too shallow, the drug absorption rate will be reduced. If the insertion is too deep, the drug will be delivered to the trachea. Therefore, it is difficult to insert the syringe into the accurate area, thus affecting the drug administration effect. In addition, the size of ordinary syringes is difficult to insert into the mouse nasal cavity, and the mouse nasal tissue is easily damaged during the insertion process. When administering drugs using ordinary injection methods, the drug stays in the nasal cavity for a short time and is easily removed by breathing or nasal clearance mechanisms, resulting in a low absorption rate. Summary of the invention

[0003] In view of the above problems, the purpose of the present invention is to provide a small animal nasal drug delivery device that can safely and accurately deliver drugs to the nasal cavity of mice.

[0004] To achieve the above object, the present invention adopts the following technical solutions: The small animal nasal drug delivery device described in the present invention includes an injection mechanism, which includes a needle; a shell, on which the injection mechanism is arranged, and the injection mechanism can rotate relative to the shell around the axial direction of the needle; a sleeve, which is arranged at the front end of the shell and movably sleeved on the outer periphery of the needle; and a position measurement module, which is arranged at the front end of the sleeve.

[0005] In the small animal nasal drug delivery device, preferably, the needle is coaxially arranged with the sleeve, the front end of the sleeve is provided with a hemispherical end surface, and the hemispherical end surface is provided with a through hole capable of inserting the needle.

[0006] In the small animal nasal drug delivery device, preferably, the position measurement module comprises a signal transmitting unit and a signal receiving unit, and both the signal transmitting unit and the signal receiving unit are arranged on the hemispherical end surface.

[0007] In the small animal nasal drug delivery device, preferably, the signal transmitting unit and the signal receiving unit are both provided in plurality, and the signal transmitting unit and the plurality of signal receiving units are alternately arranged on the hemispherical end surface around the circumference of the needle.

[0008] In the small animal nasal drug delivery device, preferably, the sleeve is provided with a sensor, and the signal transmitting unit and the signal receiving unit are both electrically connected to the sensor.

[0009] In the small animal nasal drug delivery device, preferably, the sleeve comprises an inner wall and an outer wall, a receiving space is formed between the inner wall and the outer wall, and the sensor is located in the receiving space.

[0010] The small animal nasal drug delivery device is preferably provided with an electric wire in the sleeve, the front end of the electric wire is connected to the rear end of the sensor, and the rear end of the electric wire extends along the accommodating space to the outside of the sleeve.

[0011] The small animal nasal drug delivery device preferably comprises a display screen, and the rear end of the wire is connected to the display screen.

[0012] In the small animal nasal drug delivery device, preferably, the injection mechanism comprises an atomizing pump, the atomizing pump is connected to the needle, and the atomizing pump is arranged in the housing.

[0013] In the small animal nasal drug delivery device, preferably, the injection mechanism comprises a syringe, the outer periphery of the syringe is fixedly connected to a positioning component, and the positioning component is limit-connected to the shell.

[0014] The present invention adopts the above technical solution, which has the following advantages: The injection mechanism of the small animal nasal drug delivery device of the present invention can realize drug injection, and the position measurement module can obtain the internal environment position of the mouse nasal cavity. When in use, the front end of the sleeve is inserted into the mouse nasal cavity. Since the sleeve is movably sleeved on the periphery of the needle, the needle tip of the needle is wrapped, which is not easy to damage the mouse nasal cavity tissue. The experimenter can observe the target tissue structure through the position measurement module. When the front end of the sleeve reaches the target tissue, the injection mechanism is then extended and rotated to make the needle tip section of the needle parallel to the target site, thereby realizing drug delivery at the best injection site. The small animal nasal drug delivery device of the present invention improves the accuracy, safety and efficiency of drug delivery, and is beneficial to the research and treatment of central nervous system diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Throughout the accompanying drawings, the same reference numerals are used to represent the same components. In the accompanying drawings: Figure 1 is a cross-sectional view of an embodiment of the present invention; Figure 2 It is one of the partial structural schematic diagrams of an embodiment of the present invention; Figure 3 This is the second schematic diagram of a partial structure of an embodiment of the present invention; Figure 4 It is a perspective view of an embodiment of the present invention. DETAILED DESCRIPTION

[0016] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0017] In the present application, if there is a description of directions (up, down, left, right, front and back), it is only for the convenience of describing the technical solution of the present application, and does not indicate or imply that the technical features referred to must have a specific orientation, be constructed and operate in a specific orientation. Therefore, it cannot be understood as a limitation on the present application.

[0018] In this application, "several" means one or more, "multiple" means more than two, "greater than", "less than", "exceed" and the like are understood to exclude the number itself; "above", "below", "within" and the like are understood to include the number itself. In the description of this application, if there is a description of "first" or "second", it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0019] In this application, unless otherwise clearly defined, the words "set", "install", "connect" and the like should be understood in a broad sense, for example, it can be directly connected or indirectly connected through an intermediate medium; it can be fixedly connected or detachably connected or integrally formed; it can be mechanically connected or electrically connected or able to communicate with each other; it can be the internal connection of two components or the interaction relationship between two components. The specific meanings of the above words in this application should be reasonably determined in combination with the specific content of the technical solution.

[0020] in, Figure 1 , Figure 2 and Figure 3 and Figure 4 The reference direction coordinate system of the embodiment of the present application is given. Figure 1 , Figure 2 and Figure 3 and Figure 4 The embodiment of the present application is described with reference to the direction shown.

[0021] The embodiment of the present application provides a small animal nasal drug delivery device, Figure 1 , Figure 2 and Figure 3 and Figure 4 , including an injection mechanism 100, a shell 200, a sleeve 300 and a position measurement module 400. The injection mechanism 100 includes a needle 110; the injection mechanism 100 is arranged on the shell 200, and the injection mechanism 100 can rotate relative to the shell 200 around the axial direction of the needle 110; the sleeve 300 is arranged at the front end of the shell 200, and the sleeve 300 is movably sleeved on the outer periphery of the needle 110; the position measurement module 400 is arranged at the front end of the sleeve 300.

[0022] The injection mechanism 100 of the small animal nasal drug delivery device can realize drug injection, and the position measurement module 400 can obtain the internal environment position of the mouse nasal cavity. When in use, the front end of the sleeve 300 penetrates into the mouse nasal cavity. Since the sleeve 300 is movably sleeved on the outer periphery of the needle 110, the needle tip of the needle 110 is wrapped, and it is not easy to damage the mouse's nasal tissue. The experimenter can observe the target tissue structure through the position measurement module 400. When the front end of the sleeve 300 reaches the target tissue, the injection mechanism 100 is then rotated and extended to make the needle tip section of the needle 110 parallel to the target site, so as to achieve drug delivery at the optimal injection site. The small animal nasal drug delivery device improves the accuracy, safety and efficiency of drug delivery, which is beneficial to the research and treatment of central nervous system diseases.

[0023] In some embodiments, the injection mechanism 100 can move axially relative to the shell 200. When the small animal transnasal drug delivery device is inserted into the mouse nasal cavity, the needle tip of the needle 110 is retracted into the sleeve 300. After the injection position is determined by the position measurement module 400, the needle tip of the needle 110 is extended out of the sleeve 300 to align with the injected area for injection. After confirmation, the target site is accurately administered. The administration speed and volume are selected by the control platform to control the injection needle for injection, which effectively reduces the damage to the mouse nasal cavity. The mouse nasal cavity is narrow, and the distance from the nasal cavity to the cribriform plate is about 5mm to 7mm. The front end diameter of the sleeve 300 of the small animal transnasal drug delivery device is 0.5mm, and the sleeve 300 contains a channel with a diameter of 0.2mm, which can be used for the injection needle 110 to retract and rotate. During the nose-to-brain delivery process, the drug enters the brain mainly through the nasal mucosa through the cribriform plate, and enters various areas of the brain such as the olfactory bulb (OB) along the olfactory nerve pathway. After the injection position is determined, the needle tip of the needle 110 is extended to the sieve plate to improve the drug absorption rate.

[0024] In some embodiments, the needle 110 is coaxially arranged with the sleeve 300 , and a hemispherical end surface 310 is provided at the front end of the sleeve 300 , and a through hole into which the needle 110 can be inserted is provided on the hemispherical end surface 310 .

[0025] In some embodiments, the position measurement module 400 includes a signal transmitting unit 410 and a signal receiving unit 420 to form an ultrasonic probe. The ultrasonic probe sends ultrasonic waves to the tissue. After the signal receiving unit 420 receives the ultrasonic signal, it is displayed on a display screen. The signal transmitting unit 410 and the signal receiving unit 420 are both arranged on the hemispherical end surface 310. The hemispherical end surface 310 has a smooth surface. Even if the sleeve 300 rotates in the mouse nasal cavity, it will not cause damage to the inner wall of the mouse nasal cavity, effectively reducing the damage to the mouse tissue. It can be understood that the hemispherical end surface 310 at the front end of the sleeve 300 requires appropriate surface treatment technology, such as coating or polishing, to improve the wear resistance and smoothness of the probe.

[0026] In some embodiments, a plurality of signal transmitting units 410 and a plurality of signal receiving units 420 are provided, and the signal transmitting units 410 and the plurality of signal receiving units 420 are alternately arranged on the hemispherical end surface 310 around the circumference of the needle 110. Specifically, the signal transmitting unit 410 and the signal receiving unit 420 utilize the technical principle of ultrasonic imaging, that is, a method of obtaining a visible image of an object using ultrasonic waves, and have the advantages of safe, non-invasive, and real-time imaging. The signal transmitting unit 410 and the signal receiving unit 420 can monitor the distance between the end and the sieve plate in real time, realize visualization of the image in the nasal cavity during drug administration, and significantly improve the accuracy and success rate of nasal drug administration.

[0027] In some embodiments, a sensor 360 is provided on the sleeve 300, and the signal transmitting unit 410 and the signal receiving unit 420 are both electrically connected to the sensor 360 to collect acquired information and transmit it to the sensor. The sensor 360 is connected to the display screen. Specifically, the sensor 360 includes a spatial position sensor, which receives the ultrasonic emission time of the signal transmitting unit 410 and the time when the signal receiving unit 420 receives the echo, and measures the propagation time and intensity between the two. By calculating the propagation time, the distance between the object and the probe can be determined. The spatial position sensor combined with multiple probes or multiple measuring points can obtain the position information of the front end of the sleeve 300 in three-dimensional space.

[0028] Specifically, a processor is provided between the sensor 360 and the display screen. The sensor 360 transmits a signal to the processor, and the processor processes the signal to obtain an image and displays it on the display screen.

[0029] In some embodiments, the sleeve 300 includes an inner wall 320 and an outer wall 330, and a receiving space 340 is formed between the inner wall 320 and the outer wall 330. The sensor 360 is located in the receiving space 340. This optimizes the overall structure of the small animal nasal drug delivery device, protects the sensor 360, avoids the direct impact of the external environment on the sensor 360, ensures the improved measurement accuracy of the sensor 360, reduces external interference, and facilitates the installation and maintenance of the sensor 360, making it easy to assemble and disassemble.

[0030] In some embodiments, a wire 350 is provided in the sleeve 300, and the front end of the wire 350 is connected to the rear end of the sensor 360, and the rear end of the wire 350 extends along the accommodating space 340 to the outside of the sleeve 300, hiding the wire 350 between the inner wall 320 and the outer wall 330 of the sleeve 300. This can effectively protect the wire 350, reduce damage to the wire 350 caused by external factors, and effectively improve safety, reduce the risk of electric shock to workers, and such a setting is beautiful and neat, so that the wire 350 is hidden inside the sleeve 300.

[0031] In some embodiments, the small animal nasal drug delivery device also includes a display screen, and the rear end of the wire 350 is connected to the display screen. The small animal nasal drug delivery device is connected to a control platform, and the control platform is connected to the sensor and the display screen for use, which is convenient and fast. The display screen can display the signals collected by the signal transmitting unit 410 and the signal receiving unit 420 on the display screen, which is convenient for real-time monitoring and operation.

[0032] It is understandable that the rear end of the housing 200 is provided with a wire outlet for passing the wires 350 through.

[0033] In some embodiments, the injection mechanism 100 includes an atomizer pump 120, which is connected to the needle 110 and is disposed in the housing 200. The atomizer pump 120 can fully atomize the drug to ensure the absorption rate of the drug in the nasal mucosa. The atomizer pump 120 can increase the fluid pressure to make the drug delivery and absorption more uniform and efficient, thereby improving the drug absorption effect of mice. It can be understood that the atomizer pump 120 can be a centrifugal pump, a screw pump, a plunger pump, etc., so as to achieve the atomization of the drug.

[0034] In some embodiments, the injection mechanism 100 includes a syringe 130, and a positioning component 140 is fixedly connected to the outer periphery of the syringe 130. The positioning component 140 is limitedly connected to the shell 200. The measuring range of the syringe 130 is 20 μL and is provided with a fine scale. When in use, the amount of medicine to be administered to the mouse can be judged by observing the scale on the outer wall of the syringe 130.

[0035] The injection mechanism 100 includes a core rod 150 and a positioning plate 160 that are fixedly connected. The positioning plate 160 is arranged in the shell 200 and can move along the axial direction of the needle 110. The entire section of the core rod 150 extends into the syringe 130. The positioning plate 160 drives the core rod 150 to move, squeezes the medicine in the syringe 130, and makes the medicine atomized by the atomization pump 120 and then transported from the needle 110 to the mouse nasal cavity.

[0036] The small animal nasal drug delivery device is also provided with a control platform, a display screen is arranged on the control platform, and a pushing mechanism is also arranged on the control platform, and the pushing mechanism is connected to the positioning plate 160 to achieve accurate control of the drug delivery amount. It can be understood that the pushing mechanism may include a motor, a ball screw and a nut seat, the output shaft of the motor is connected to the ball screw, and the nut seat is connected to the positioning plate 160. By changing the speed and working time of the motor, the ball screw drives the nut seat to move, so as to adjust the speed of the drug delivery amount and the total injection amount; the pushing mechanism may also include an electric push rod, which is connected to the positioning plate 160 to drive the movement of the core rod 150 to adjust the drug delivery amount. The greater the pushing distance, the greater the drug delivery amount. The drug delivery speed is adjusted by controlling the speed of the electric push rod. The above two methods can accurately control the injection rate and volume, making the drug delivery more stable and accurate.

[0037] The method of using the small animal nasal drug delivery device is: 1. Drug preparation: Load the required drug into the injection mechanism 100.

[0038] 2. Insert the front end of the sleeve 300 into the nasal cavity of the mouse and monitor it in real time through the display screen. The specific operation method is: grab the lightly anesthetized mouse with the left hand, make the mouse lie on its back, appropriately raise the head and neck of the mouse, hold the small animal nasal drug delivery device with the right hand, carefully and slowly insert the front end of the sleeve 300 into the mouse nostril, and at the same time, monitor in real time through the display screen whether the end position of the probe reaches the sieve plate area.

[0039] 3. Injection: After confirming the injection position, operate the injection mechanism 100 to push out (the injection mechanism 100 moves relative to the housing 200) until the needle 110 extends out of the front end of the sleeve 300, and rotate the injection mechanism 100 to make the needle tip section of the needle 110 parallel to the target site, set the pushing speed of the core rod 150 to between 2.5μL / 2 minutes and 2.5μL / 3 minutes, and set the administration volume for each nasal cavity to 10μL.

[0040] 4. After the drug administration is completed, the control platform is operated to sequentially retract the needle 110 (i.e., the needle 110 is retracted to the front end of the sleeve 300), slowly withdraw the front end of the sleeve 300 from the mouse nasal cavity, and turn off the switches of each part of the equipment.

[0041] 5. Keep the mouse in supine position for at least 30 min to ensure complete absorption of the drug.

[0042] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A nasal drug delivery device for small animals, characterized in that: include an injection mechanism, the injection mechanism comprising a needle; A housing, the injection mechanism being arranged on the housing, and the injection mechanism being capable of rotating relative to the housing around the axial direction of the needle; A sleeve, the sleeve is arranged at the front end of the housing, and the sleeve is movably sleeved on the outer periphery of the needle; A position measurement module is arranged at the front end of the sleeve.

2. The small animal nasal drug delivery device according to claim 1, characterized in that: The needle is coaxially arranged with the sleeve, the front end of the sleeve is provided with a hemispherical end surface, and the hemispherical end surface is provided with a through hole capable of inserting the needle.

3. The small animal nasal drug delivery device according to claim 2, characterized in that: The position measurement module comprises a signal transmitting unit and a signal receiving unit, and both the signal transmitting unit and the signal receiving unit are arranged on the hemispherical end surface.

4. The small animal nasal drug delivery device according to claim 3, characterized in that: There are a plurality of the signal transmitting units and a plurality of the signal receiving units, and the signal transmitting units and the plurality of the signal receiving units are alternately arranged on the hemispherical end surface around the circumference of the needle.

5. The small animal nasal drug delivery device according to claim 3, characterized in that: The sleeve is provided with a sensor, and the signal transmitting unit and the signal receiving unit are both electrically connected to the sensor.

6. The small animal nasal drug delivery device according to claim 5, characterized in that: The sleeve comprises an inner wall and an outer wall, an accommodating space is formed between the inner wall and the outer wall, and the sensor is located in the accommodating space.

7. The small animal nasal drug delivery device according to claim 6, characterized in that: An electric wire is arranged in the sleeve, the front end of the electric wire is connected to the rear end of the sensor, and the rear end of the electric wire extends along the accommodating space to the outside of the sleeve.

8. The small animal nasal drug delivery device according to claim 7, characterized in that: A display screen is included, and the rear end of the electric wire is connected to the display screen.

9. The small animal nasal drug delivery device according to claim 1, characterized in that: The injection mechanism comprises an atomizing pump, the atomizing pump is communicated with the needle, and the atomizing pump is arranged in the housing.

10. The small animal nasal drug delivery device according to claim 9, characterized in that: The injection mechanism comprises a syringe, the outer periphery of which is fixedly connected with a positioning component, and the positioning component is limitatively connected to the housing.

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