Mosquito-repellent shower balm containing natural plant mosquito-repellent extract as well as preparation method and application of mosquito-repellent shower balm

Abstract

The invention provides mosquito-repellent shower balm containing natural plant mosquito-repellent extracts as well as a preparation method and application of the mosquito-repellent shower balm, and belongs to the technical field of balm preparation. The mosquito-repelling shower head balsam is prepared from the following components in percentage by weight: 1.5 to 3 percent of a thickening agent, 15 to 25 percent of a solubilizer, 40 to 50 percent of plant essential oil, 0.2 to 0.5 percent of an emulsifying agent, 0.1 to 0.3 percent of a chelating agent, 0.1 to 0.5 percent of an antioxidant, 0.5 to 1.5 percent of a preservative, 0.3 to 0.8 percent of a slow release agent and the balance of water. A mixture of eucalyptus citriodora oil, rosemary essential oil, lavender essential oil and clove essential oil is used as mosquito-repelling essential oil, a mixture of propylene glycol algal protein acid ester, algal protein acid sodium and microcrystalline cellulose is used as a thickening agent, and in the implementation process, it is accidentally found that when the plant essential oil and the thickening agent are mixed for use, not only can the mosquito-repelling effect be achieved, but also the mosquito-repelling effect is achieved. And long-acting mosquito repelling can be realized.

Description

Technical Field

[0001] The invention belongs to the technical field of ointment preparation, and particularly relates to a mosquito repellent shower ointment containing a natural plant mosquito repellent extract, and a preparation method and application thereof. Background Art

[0002] After entering the summer, due to the influence of humid weather and high temperature, mosquitoes are active, biting people to suck blood, disturbing people, affecting people's rest and sleep, and thus affecting the quality of life and work. Because there are several chemical substances in mosquito saliva, it can cause skin redness, swelling, pain and itching, and even cause secondary infection. Through bites, mosquitoes can also spread a variety of diseases. They are carriers and spreaders of bacteria and viruses of infectious diseases such as dengue fever, malaria, Japanese encephalitis, yellow fever, chikungunya fever, West Nile encephalitis, etc. Since ancient times, people have known how to use various plant materials to fumigate mosquitoes, such as mugwort, mint, cloves, etc. This is because these plants contain natural fragrance ingredients that have mosquito repellent effects. With the development of the chemical industry, people have extracted natural fragrances from these plants, that is, various plant essential oils, and use these plant essential oils to achieve the purpose of mosquito repellent.

[0003] As people's quality of life improves, their requirements for bathing are no longer limited to cleaning and cleansing the skin, but also require certain functions while bathing. Most of the shower heads on the market currently only provide people with simple shower functions. In today's rapidly developing world, simple shower functions can no longer meet people's needs. Bath balm is a product used with a shower head during bathing. It is dissolved in water in the shower head and sprayed on the user through the shower head, thereby achieving whitening, moisturizing, mosquito repellent and other effects.

[0004] For example, Chinese patent CN210614058U discloses a slow-release perfume stick for perfume atomizing nozzle, which can realize that the water spray head sprays out bath liquid with perfume, and the bath liquid sprayed by the water spray head has perfume, which makes people feel refreshed and comfortable, and bathing is cleaner.

[0005] Chinese patent CN102648707A discloses a mosquito repellent filter element, comprising porous material powder particles, wherein the porous material separation carries a medicament with a mosquito repellent smell. The preparation method of this mosquito repellent filter element comprises the following steps: placing the porous material powder particles in the medicament with a mosquito repellent smell, heating in a water bath, cooling after sufficient hot soaking, and then filtering to obtain the mosquito repellent filter element. The prepared filter element is placed in a shower head for showering. During showering, water flows through the filter element, and the medicament will be dissolved and slowly released with the water flow and sprinkled on the body. The medicament has a smell that mosquitoes hate and retreat but the human body itself can accept. After spraying on the body, it can achieve the effect of refreshing and repelling mosquitoes, and can also resist antibacterial. After the shower is finished, the smell attached to the body surface can still last for several hours. Mosquitoes can be repelled by showering every day. The method is simple and effective.

[0006] However, the existing mosquito repellent bath ointments generally have defects such as poor mosquito repellent effect and short duration. Therefore, it is necessary to develop a mosquito repellent shower ointment containing natural plant mosquito repellent extracts with good mosquito repellent effect, long duration, high stability and good sustained release effect, and a preparation method thereof. Summary of the invention

[0007] In view of the deficiencies in the prior art, the present invention aims to provide a mosquito repellent shower ointment containing natural plant mosquito repellent extracts, which has good mosquito repellent effect, long duration, high stability and good sustained-release effect, as well as a preparation method and application thereof.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions: On the one hand, the present invention provides a mosquito repellent shower ointment containing a natural plant mosquito repellent extract, which comprises the following components by weight percentage: 1.5-3% thickener, 15-25% solubilizer, 40-50% plant essential oil, 0.2-0.5% emulsifier, 0.1-0.3% chelating agent, 0.1-0.5% antioxidant, 0.5-1.5% preservative, 0.3-0.8% sustained-release agent and the remainder water.

[0009] Preferably, the essential oil shower ointment comprises the following components by weight percentage: 2-2.5% thickener, 18-20% solubilizer, 42-55% plant essential oil, 0.3-0.4% emulsifier, 0.2-0.3% chelating agent, 0.2-0.3% antioxidant, 0.8-1.2% preservative, 0.4-0.6% sustained-release agent and the remainder water.

[0010] in, The thickener is a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose; The mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1-3:1-3:5-10; Preferably, the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 2:2:8.

[0011] The present invention uses a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose as a thickener, and controls the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose to be 1-3:1-3:5-10, which can achieve a thickening effect on the one hand, and can better absorb plant essential oils on the skin surface on the other hand, thereby achieving a long-lasting mosquito repellent effect.

[0012] As some preferred embodiments, the propylene glycol alginate has a weight percentage of 0.2-0.6%, preferably 0.3-0.5%, more preferably 0.4-0.5%, and further preferably 0.4%.

[0013] As some preferred embodiments, the sodium alginate has a weight percentage of 0.2-0.6%, preferably 0.3-0.5%, more preferably 0.4-0.5%, and further preferably 0.4%.

[0014] As some preferred embodiments, the microcrystalline cellulose has a weight percentage of 1-2%, preferably 1.2-1.8%, more preferably 1.5-1.7%, and further preferably 1.6%.

[0015] As a preferred embodiment, the thickener is composed of 0.4% propylene glycol alginate, 0.4% sodium alginate and 1.6% microcrystalline cellulose by weight percentage.

[0016] As some preferred embodiments, the solubilizer is glycerol.

[0017] The plant essential oil is a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil; Preferably, the mass ratio of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 5-10:3-5:3-5:1-2; More preferably, the mass ratio of the lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 8:4:4:2.

[0018] As some preferred embodiments, the emulsifier is microcrystalline wax.

[0019] As some preferred embodiments, the chelating agent is disodium EDTA.

[0020] As some preferred embodiments, the antioxidant is a mixture of tocopherol and ascorbic acid; The mass ratio of tocopherol to ascorbic acid is 1:1; As some preferred embodiments, the tocopherol has a weight percentage of 0.05-0.25%, preferably 0.08-0.2%, more preferably 0.1-0.15%, and further preferably 0.1%.

[0021] As some preferred embodiments, the ascorbic acid has a weight percentage of 0.05-0.25%, preferably 0.08-0.2%, more preferably 0.1-0.15%, and further preferably 0.1%.

[0022] As a preferred embodiment, the antioxidant consists of 0.1% tocopherol and 0.1% ascorbic acid by weight.

[0023] As some preferred implementation schemes, the preservative is a mixture of phenoxyethanol and sodium benzoate, and the mass ratio of the two is 1:1.

[0024] As some preferred embodiments, the sustained-release agent is silica.

[0025] As a preferred embodiment, the essential oil shower ointment comprises the following components by weight percentage: 0.4% propylene glycol alginate, 0.4% sodium alginate, 1.6% microcrystalline cellulose, 20% glycerin, 20% lemon eucalyptus oil, 10% rosemary essential oil, 10% lavender essential oil, 5% clove essential oil, 0.3% microcrystalline wax, 0.2% disodium EDTA, 0.1% tocopherol, 0.1% ascorbic acid, 0.5% phenoxyethanol, 0.5% sodium benzoate, 0.5% silica and the balance water.

[0026] On the other hand, the present invention also provides a method for preparing the mosquito repellent shower ointment containing the natural plant mosquito repellent extract, comprising the following steps: (1) Mix and disperse the plant essential oil and the sustained-release agent for 3-5 minutes to obtain solution 1; (2) mixing part of the thickener, solubilizer and part of the preservative and dispersing them for 3-5 minutes to obtain solution 2; (3) Add the remaining thickener and the remaining preservative into water, stir evenly and heat to 80-90°C. After the mixture is completely dissolved, keep the temperature constant for 10-20 minutes to obtain a mixed solution. (4) Add the chelating agent to the mixed solution and continue to stir at a constant temperature for 3-5 minutes, then cool it to 60-70°C, add solution 1 and solution 2, stir at a constant temperature for 3-5 minutes, then cool it to 40-50°C, add the antioxidant, continue to stir for 10-15 minutes, pour it into a mold, cool it down, and then obtain the mosquito repellent shower ointment.

[0027] In another aspect, the present invention further provides the use of the mosquito repellent showerhead ointment as a showerhead filter element, which is applied in the field of bathing.

[0028] Compared with the prior art, the present invention has the following beneficial effects: (1) The present invention uses a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil as mosquito repellent essential oil and controls the mass ratio of the four essential oils to obtain a mosquito repellent ointment with better mosquito repellent effect.

[0029] (2) The present invention uses a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose as a thickener. During the implementation process, it was unexpectedly found that by controlling the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose and mixing them with the plant essential oil used in this application, the plant essential oil can be better absorbed and the plant essential oil can be better adsorbed on the skin surface, thereby achieving a long-lasting mosquito repellent effect. DETAILED DESCRIPTION

[0030] The above features mentioned in the present invention or the features mentioned in the embodiments can be combined in any way. All the features explained in the specification of this case can be used in combination with any method form, and each feature disclosed in the specification can be replaced by any alternative feature that can provide the same, equal or similar purpose. Therefore, unless otherwise specified, the disclosed features are only general examples of equal or similar features.

[0031] The present invention will be further described below in conjunction with specific examples. These examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In the following examples, the implementation methods for specifying specific conditions are usually based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise specified, all percentages and fractions are by weight.

[0032] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those known to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein can be applied to the methods of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0033] The components used in the following examples were all purchased from Guangzhou Huayue Medical Aesthetics Research Institute.

[0034] Example 1 A mosquito repellent shower ointment containing natural plant mosquito repellent extract

[0035] Preparation method: The steps include: (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1; (2) mixing propylene glycol alginate, glycerin and phenoxyethanol and dispersing them for 5 minutes to obtain solution 2; (3) Add sodium alginate, microcrystalline cellulose and sodium benzoate into water, stir evenly and heat to 85°C. After the water is completely dissolved, keep the temperature constant for 15 minutes to obtain a mixed solution. (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes. The mixture is then cooled to 65°C, and solution 1 and solution 2 are added. The mixture is stirred at a constant temperature for 5 minutes. The mixture is then cooled to 45°C, tocopherol and ascorbic acid are added, and stirring is continued for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0036] Example 2 A mosquito repellent shower ointment containing natural plant mosquito repellent extract

[0037] Preparation method: The steps include: (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1; (2) mixing propylene glycol alginate, glycerin and phenoxyethanol and dispersing them for 5 minutes to obtain solution 2; (3) Add sodium alginate, microcrystalline cellulose and sodium benzoate into water, stir evenly and heat to 85°C. After the water is completely dissolved, keep the temperature constant for 15 minutes to obtain a mixed solution. (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes. The mixture is then cooled to 65°C, and solution 1 and solution 2 are added. The mixture is stirred at a constant temperature for 5 minutes. The mixture is then cooled to 45°C, tocopherol and ascorbic acid are added, and stirring is continued for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0038] Example 3 A mosquito repellent shower ointment containing natural plant mosquito repellent extract

[0039] Preparation method: The steps include: (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1; (2) mixing propylene glycol alginate, glycerin and phenoxyethanol and dispersing them for 5 minutes to obtain solution 2; (3) Add sodium alginate, microcrystalline cellulose and sodium benzoate into water, stir evenly and heat to 85°C. After the water is completely dissolved, keep the temperature constant for 15 minutes to obtain a mixed solution. (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes. The mixture is then cooled to 65°C, and solution 1 and solution 2 are added. The mixture is stirred at a constant temperature for 5 minutes. The mixture is then cooled to 45°C, tocopherol and ascorbic acid are added, and stirring is continued for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0040] Comparative Example 1 The difference from Example 3 is that the type of thickener is different, only microcrystalline cellulose is added, and the rest is the same as Example 3.

[0041] Comparative Example 2 The difference from Example 3 is that the component ratio of the thickener is different, and the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1:1:1, that is:

[0042] The rest is the same as Example 3.

[0043] Comparative Example 3 The difference from Example 3 is that the type of plant essential oil is different, only lemon eucalyptus oil is added, and the rest is the same as Example 3.

[0044] Comparative Example 4 The difference from Example 3 is that the component ratio of the plant essential oil is different, and the mass ratio of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 10:1:1:3, that is:

[0045] Effect test: 1. Irritation test Take 40 adult, healthy rabbits with intact skin and divide them into 10 groups, 4 rabbits in each group; try the mosquito repellent ointment (as the test substance) prepared in Examples 1-3 and Comparative Examples 1-4 respectively. 24 hours before the test, cut the hair on both sides of the rabbit's back spine without damaging the epidermis. The hair removal range is 3cm×3cm on the left and right, and the application area is 2.5cm×2.5cm. Take 0.5g of the test substance and apply it on the left side of the skin, and apply an equal amount of distilled water on the right side as a control. Apply once a day for 14 consecutive days. Starting from the second day, the hair should be removed before each application, and the residual test substance should be removed with warm water. Observe the skin irritation reaction one hour later and score and judge the irritation according to the "Safety Technical Specifications for Cosmetics" (2015 Edition).

[0046] The test results show that the reaction integral after using the mosquito repellent ointment prepared in Examples 1-3 and Comparative Examples 1-4 is 0.00, which is non-irritating. This result shows that the mosquito repellent ointment prepared in Examples 1-3 and Comparative Examples 1-4 is non-irritating, indicating that the raw materials used have good safety.

[0047] 2. Mosquito repellent effect test 1. Test materials: Examples 1-3, Comparative Examples 1-4; 2. Test subjects: Test insects: Aedes albopictus, adults that have not fed blood for 4 days after emergence, half male and half female; reared indoors; rearing conditions: temperature (26±1)℃, relative humidity (65±5)%; Testers: 14 test personnel with qualified attack capabilities.

[0048] 3. Test method: The mosquito repellent effect test was conducted using the method of GB / T 13917.9-2009 “Indoor efficacy test and evaluation of public health insecticides for registered pesticides Part 9: Repellents”.

[0049] Mosquito attack power test: 300 mosquitoes are placed in a mosquito cage with a length × width × height of 40cm × 30cm × 30cm respectively. The experimenter's arm is exposed to a 4cm × 4cm skin area, and the rest is covered. Put the arm into the mosquito cage for 2 minutes, and record the number of mosquitoes that come and land. If there are more than 30 mosquitoes, the attack power is qualified, and the experimenter and the mosquito cage can be used for repellent experiments. Repellency test: 7 subjects with qualified attack power were selected, and a 4 cm × 4 cm skin area was exposed on each of their two arms as described above. One arm was set as a blank control without any application, and the exposed part of the other arm was applied with 1.5 μg / cm 2 Apply the test substance evenly at a dose of 1000 mg / kg, then rinse with clean water and put your arm into a mosquito cage with qualified attack power for 2 minutes to observe whether there are mosquitoes coming to suck blood. Then test once every hour. As long as there are mosquitoes coming to suck blood, the repellent is considered to be ineffective and the effective protection time (h) of the repellent is recorded. Each person repeats 5 times in each case.

[0050] Effective protection rate test: 7 test subjects with qualified attack power were selected, and 4cm × 4cm skin area was exposed on both arms as described above. One arm was set as a blank control without any application, and the exposed part of the other arm was applied at 1.5μg / cm 2 Apply the test substance evenly with a dose of 100 mg / kg. Then rinse with clean water, leave for 10 hours, and then put your hand into the cage and stay for 100 seconds. Repeat 5 times per person in each case. Calculate the effective protection rate (%) based on the number of Aedes albopictus staying on the arm.

[0051] Effective protection rate (%) = [(average number of stings in the control group - average number of stings in the test group) / average number of stings in the control group] × 100.

[0052] The test results are shown in Table 1 below.

[0053] Table 1

[0054] According to the test results in Table 1 above, the effective protection time of the mosquito repellent shower ointment in the present invention can reach more than 8 hours, and the effective protection rate of 10 hours can reach more than 78%. From the test results of Comparative Examples 1-2, it can be seen that the type and ratio of the thickener in the mosquito repellent shower ointment have no significant effect on the effective protection time of mosquito repellent, but the effective protection rate after 10 hours is significantly reduced; it shows that the type of thickener will affect the long-term mosquito repellent effect of the ointment; from the test results of Comparative Examples 3-4, it can be seen that the plant essential oils in the mosquito repellent shower ointment interact with each other, and the specific composition and mass ratio of the essential oils have a significant effect on the effective protection time of its mosquito repellent, but the effective protection rate of 10 hours can still reach more than 70%.

[0055] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A mosquito repellent shower ointment containing natural plant mosquito repellent extracts, characterized in that: The composition comprises the following components by weight percentage: thickener 1.5-3%, solubilizer 15-25%, plant essential oil 40-50%, emulsifier 0.2-0.5%, chelating agent 0.1-0.3%, antioxidant 0.1-0.5%, preservative 0.5-1.5%, sustained-release agent 0.3-0.8% and the balance of water; The thickener is a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose; the plant essential oil is a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil.

2. The mosquito repellent shower ointment according to claim 1, characterized in that: The composition includes the following components by weight percentage: 2-2.5% thickener, 18-20% solubilizer, 42-55% plant essential oil, 0.3-0.4% emulsifier, 0.2-0.3% chelating agent, 0.2-0.3% antioxidant, 0.8-1.2% preservative, 0.4-0.6% sustained-release agent and 30-40% water.

3. The mosquito repellent shower ointment according to claim 1, characterized in that: The mass ratio of the propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1-3:1-3:5-10.

4. The mosquito repellent shower ointment according to claim 3, characterized in that: The mass ratio of the propylene glycol alginate, sodium alginate and microcrystalline cellulose is 2:2:

8.

5. The mosquito repellent shower ointment according to claim 1, characterized in that: The mass ratio of the lemon eucalyptus oil, the rosemary essential oil, the lavender essential oil and the clove essential oil is 5-10:3-5:3-5:1-2.

6. The mosquito repellent shower ointment according to claim 5, characterized in that: The mass ratio of the lemon eucalyptus oil, the rosemary essential oil, the lavender essential oil and the clove essential oil is 8:4:4:

2.

7. The mosquito repellent shower ointment according to claim 1, characterized in that: The emulsifier is microcrystalline wax; the chelating agent is disodium EDTA; the solubilizer is glycerol; the antioxidant is a mixture of tocopherol and ascorbic acid; the preservative is a mixture of phenoxyethanol and sodium benzoate; and the sustained-release agent is silica.

8. The mosquito repellent shower ointment according to claim 7, characterized in that: The composition comprises the following components by weight percentage: 0.4% propylene glycol alginate, 0.4% sodium alginate, 1.6% microcrystalline cellulose, 20% glycerin, 20% lemon eucalyptus oil, 10% rosemary essential oil, 10% lavender essential oil, 5% clove essential oil, 0.3% microcrystalline wax, 0.2% disodium EDTA, 0.1% tocopherol, 0.1% ascorbic acid, 0.5% phenoxyethanol, 0.5% sodium benzoate, 0.5% silica and the balance water.

9. The method for preparing the mosquito repellent shower ointment according to any one of claims 1 to 8, characterized in that: The steps include: (1) Mix and disperse the plant essential oil and the sustained-release agent for 3-5 minutes to obtain solution 1; (2) mixing part of the thickener, solubilizer and part of the preservative and dispersing them for 3-5 minutes to obtain solution 2; (3) Add the remaining thickener and the remaining preservative into water, stir evenly and heat to 80-90°C. After the mixture is completely dissolved, keep the temperature constant for 10-20 minutes to obtain a mixed solution. (4) Add the chelating agent and emulsifier to the mixed solution and continue to stir at a constant temperature for 3-5 minutes, then cool it to 60-70°C, add solution 1 and solution 2, stir at a constant temperature for 3-5 minutes, then cool it to 40-50°C, add the antioxidant, continue to stir for 10-15 minutes, pour it into a mold, cool it down, and then obtain the mosquito repellent shower ointment.

10. Use of the mosquito repellent shower ointment according to any one of claims 1 to 8 in preparing a shower filter element.

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