A mosquito repellent shower ointment containing natural plant mosquito repellent extracts and its preparation method and application

Abstract

The present invention provides a mosquito repellent shower ointment containing a natural plant mosquito repellent extract, and its preparation method and application, belonging to the technical field of ointment preparation. The mosquito repellent shower ointment comprises the following components by weight percentage: a thickener 1.5-3%, a solubilizer 15-25%, a plant essential oil 40-50%, an emulsifier 0.2-0.5%, a chelating agent 0.1-0.3%, an antioxidant 0.1-0.5%, a preservative 0.5-1.5%, a sustained-release agent 0.3-0.8% and a water balance. The present invention uses a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil as the mosquito repellent essential oil, and a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose as the thickener. During implementation, it was unexpectedly found that the combination of the plant essential oil and the thickener can not only repel mosquitoes, but also repel mosquitoes in a long-lasting manner.

Description

Technical Field

[0001] The invention belongs to the technical field of ointment preparation, and particularly relates to a mosquito repellent shower ointment containing a natural plant mosquito repellent extract, and a preparation method and application thereof. Background Art

[0002] With the arrival of summer, the humid and hot weather encourages mosquito activity, causing them to bite and suck blood, disturbing people and disrupting their rest and sleep, thus affecting their quality of life and work. Mosquito saliva contains several chemicals that can cause skin redness, swelling, itching, and even secondary infections. Through their bites, mosquitoes can also spread a variety of diseases, acting as carriers and transmitters of bacteria and viruses such as dengue fever, malaria, Japanese encephalitis, yellow fever, chikungunya, and West Nile encephalitis. Since ancient times, people have used various plant materials, such as mugwort, mint, and cloves, to repel mosquitoes. This is because these plants contain natural fragrance ingredients with mosquito repellent properties. With the development of the chemical industry, natural fragrances, namely various plant essential oils, have been extracted from these plants to repel mosquitoes.

[0003] As people's quality of life improves, their bathing needs go beyond simply cleansing and purifying their skin; they also demand benefits. Most showerheads currently on the market simply provide a shower, but in today's rapidly developing world, this simple function no longer meets these needs. Bath balms are products used in conjunction with showerheads. They dissolve in water and are sprayed onto the user's skin through the showerhead, achieving benefits such as whitening, moisturizing, and mosquito repellent.

[0004] For example, Chinese patent CN210614058U discloses a slow-release perfume stick for a perfume atomizing nozzle, which can enable the spray head to spray perfumed bath liquid. The bath liquid sprayed by the spray head has perfume, which makes people feel refreshed and comfortable, and makes bathing cleaner.

[0005] Chinese patent CN102648707A discloses a mosquito repellent filter element comprising a porous material powder containing a mosquito repellent odorant. The method for preparing this mosquito repellent filter element comprises the following steps: placing the porous material powder in the mosquito repellent odorant, heating the porous material powder in a water bath, fully hot-soaking the powder, cooling the powder, and then filtering the powder to obtain the mosquito repellent filter element. The prepared filter element is placed in a shower head. During showering, water flows through the filter element, dissolving the odorant in the water and slowly releasing it onto the body. The odorant has an odor that mosquitoes dislike and avoid, but is acceptable to the human body. When sprayed on the body, the odorant not only refreshes the body but also repels mosquitoes. It also has antibacterial properties. After showering, the odorant remains on the body for several hours. This simple and effective method allows mosquito repellent by showering daily.

[0006] However, existing mosquito repellent bath ointments generally have defects such as poor mosquito repellent effect and short duration. Therefore, it is necessary to develop a mosquito repellent shower ointment containing natural plant mosquito repellent extracts with good mosquito repellent effect, long duration, high stability and good sustained release effect, and a preparation method thereof. Summary of the Invention

[0007] In view of the deficiencies in the prior art, the present invention aims to provide a mosquito repellent shower ointment containing natural plant mosquito repellent extracts, which has good mosquito repellent effect, long duration, high stability and good sustained-release effect, as well as a preparation method and application thereof.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] In one aspect, the present invention provides a mosquito repellent shower ointment containing a natural plant mosquito repellent extract, which comprises the following components by weight: 1.5-3% thickener, 15-25% solubilizer, 40-50% plant essential oil, 0.2-0.5% emulsifier, 0.1-0.3% chelating agent, 0.1-0.5% antioxidant, 0.5-1.5% preservative, 0.3-0.8% sustained-release agent and the balance water.

[0010] Preferably, the essential oil shower gel comprises the following components by weight percentage: 2-2.5% thickener, 18-20% solubilizer, 42-55% plant essential oil, 0.3-0.4% emulsifier, 0.2-0.3% chelating agent, 0.2-0.3% antioxidant, 0.8-1.2% preservative, 0.4-0.6% sustained-release agent and the balance water.

[0011] in,

[0012] The thickener is a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose;

[0013] The mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1-3:1-3:5-10;

[0014] Preferably, the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 2:2:8.

[0015] The present invention uses a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose as a thickener, and controls the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose to be 1-3:1-3:5-10. On the one hand, it can achieve a thickening effect, and on the other hand, it can better absorb plant essential oils, so that the plant essential oils are better absorbed on the skin surface, thereby achieving a long-lasting mosquito repellent effect.

[0016] As some preferred embodiments, the propylene glycol alginate has a weight percentage of 0.2-0.6%; preferably 0.3-0.5%; more preferably 0.4-0.5%; further preferably 0.4%.

[0017] As some preferred embodiments, the sodium alginate has a weight percentage of 0.2-0.6%; preferably 0.3-0.5%; more preferably 0.4-0.5%; further preferably 0.4%.

[0018] As some preferred embodiments, the microcrystalline cellulose has a weight percentage of 1-2%; preferably 1.2-1.8%; more preferably 1.5-1.7%; further preferably 1.6%.

[0019] As a preferred embodiment, the thickener consists of 0.4% propylene glycol alginate, 0.4% sodium alginate and 1.6% microcrystalline cellulose in terms of weight percentage.

[0020] As some preferred embodiments, the solubilizer is glycerol.

[0021] The plant essential oil is a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil;

[0022] Preferably, the mass ratio of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 5-10:3-5:3-5:1-2;

[0023] More preferably, the mass ratio of the lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 8:4:4:2.

[0024] As some preferred embodiments, the emulsifier is microcrystalline wax.

[0025] As some preferred embodiments, the chelating agent is disodium EDTA.

[0026] As some preferred embodiments, the antioxidant is a mixture of tocopherol and ascorbic acid;

[0027] The mass ratio of tocopherol to ascorbic acid is 1:1;

[0028] As some preferred embodiments, the tocopherol content is 0.05-0.25% by weight, preferably 0.08-0.2%, more preferably 0.1-0.15%, and further preferably 0.1%.

[0029] As some preferred embodiments, the ascorbic acid has a weight percentage of 0.05-0.25%, preferably 0.08-0.2%, more preferably 0.1-0.15%, and further preferably 0.1%.

[0030] As a preferred embodiment, the antioxidant consists of 0.1% tocopherol and 0.1% ascorbic acid by weight.

[0031] As some preferred embodiments, the preservative is a mixture of phenoxyethanol and sodium benzoate, with a mass ratio of 1:1.

[0032] As some preferred embodiments, the sustained-release agent is silica.

[0033] As a preferred embodiment, the essential oil shower gel comprises the following components by weight percentage: 0.4% propylene glycol alginate, 0.4% sodium alginate, 1.6% microcrystalline cellulose, 20% glycerin, 20% lemon eucalyptus oil, 10% rosemary essential oil, 10% lavender essential oil, 5% clove essential oil, 0.3% microcrystalline wax, 0.2% disodium EDTA, 0.1% tocopherol, 0.1% ascorbic acid, 0.5% phenoxyethanol, 0.5% sodium benzoate, 0.5% silica, and the balance water.

[0034] On the other hand, the present invention also provides a method for preparing the mosquito repellent shower ointment containing the natural plant mosquito repellent extract, comprising the following steps:

[0035] (1) Mix and disperse the plant essential oil and the sustained-release agent for 3-5 minutes to obtain solution 1;

[0036] (2) Mix part of the thickener, solubilizer, and preservative and disperse for 3-5 minutes to obtain solution 2;

[0037] (3) Add the remaining thickener and preservative to water, stir evenly, and heat to 80-90°C. After complete dissolution, keep the temperature constant for 10-20 minutes to obtain a mixed solution;

[0038] (4) Add the chelating agent to the mixed solution and continue to stir at a constant temperature for 3-5 minutes, then cool it to 60-70°C, add solution 1 and solution 2, stir at a constant temperature for 3-5 minutes, then cool it to 40-50°C, add the antioxidant, continue to stir for 10-15 minutes, pour it into a mold and cool it to obtain the mosquito repellent shower ointment.

[0039] In another aspect, the present invention further provides the use of the mosquito repellent showerhead ointment as a showerhead filter element, which is applied in the field of bathing.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] (1) The present invention uses a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil as mosquito repellent essential oil and controls the mass ratio of the four to make the obtained mosquito repellent ointment have a better mosquito repellent effect.

[0042] (2) The present invention uses a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose as a thickener. During the implementation process, it was unexpectedly found that by controlling the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose and mixing them with the plant essential oil used in this application, the plant essential oil can be better absorbed and better adsorbed on the skin surface, thereby achieving a long-lasting mosquito repellent effect. DETAILED DESCRIPTION

[0043] The features described above in the present invention, or in the embodiments, may be combined in any combination. All features described in this specification may be used in conjunction with any method or form, and each feature disclosed in this specification may be replaced by any alternative feature that serves the same, equivalent, or similar purpose. Therefore, unless otherwise specified, the features disclosed are merely general examples of equivalent or similar features.

[0044] The present invention will be further described below in conjunction with specific examples. These examples are intended to illustrate the present invention only and are not intended to limit the scope of the invention. The following examples are implementation methods for which specific conditions are noted, generally according to conventional conditions or according to the conditions recommended by the manufacturer. Unless otherwise specified, all percentages and fractions are by weight.

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those known to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the methods of the present invention. The preferred methods and materials described herein are for illustrative purposes only.

[0046] The components used in the following examples were purchased from Guangzhou Huayue Medical Aesthetics Research Institute.

[0047] Example 1 A mosquito repellent shower ointment containing natural plant mosquito repellent extracts

[0048]

[0049] Preparation method:

[0050] The steps include:

[0051] (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1;

[0052] (2) Propylene glycol alginate, glycerin, and phenoxyethanol were mixed and dispersed for 5 minutes to obtain solution 2;

[0053] (3) Sodium alginate, microcrystalline cellulose and sodium benzoate are added to water, stirred evenly and heated to 85°C. After complete dissolution, the mixture is kept at this temperature for 15 minutes to obtain a mixed solution.

[0054] (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes, then cooled to 65°C, solution 1 and solution 2 are added, stirred at a constant temperature for 5 minutes, then cooled to 45°C, tocopherol and ascorbic acid are added, and stirred for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0055] Example 2 A mosquito repellent shower ointment containing natural plant mosquito repellent extracts

[0056]

[0057] Preparation method:

[0058] The steps include:

[0059] (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1;

[0060] (2) Propylene glycol alginate, glycerin, and phenoxyethanol were mixed and dispersed for 5 minutes to obtain solution 2;

[0061] (3) Sodium alginate, microcrystalline cellulose and sodium benzoate are added to water, stirred evenly and heated to 85°C. After complete dissolution, the mixture is kept at this temperature for 15 minutes to obtain a mixed solution.

[0062] (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes, then cooled to 65°C, solution 1 and solution 2 are added, stirred at a constant temperature for 5 minutes, then cooled to 45°C, tocopherol and ascorbic acid are added, and stirred for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0063] Example 3 A mosquito repellent shower ointment containing natural plant mosquito repellent extracts

[0064]

[0065] Preparation method:

[0066] The steps include:

[0067] (1) Mix and disperse the plant essential oil and silica for 3 minutes to obtain solution 1;

[0068] (2) Propylene glycol alginate, glycerin, and phenoxyethanol were mixed and dispersed for 5 minutes to obtain solution 2;

[0069] (3) Sodium alginate, microcrystalline cellulose and sodium benzoate are added to water, stirred evenly and heated to 85°C. After complete dissolution, the mixture is kept at this temperature for 15 minutes to obtain a mixed solution.

[0070] (4) Disodium EDTA and microcrystalline wax are added to the mixture and stirred at a constant temperature for 5 minutes, then cooled to 65°C, solution 1 and solution 2 are added, stirred at a constant temperature for 5 minutes, then cooled to 45°C, tocopherol and ascorbic acid are added, and stirred for 15 minutes. The mixture is poured into a mold and cooled to obtain the essential oil flower shower ointment.

[0071] Comparative Example 1

[0072] The difference from Example 3 is that the type of thickener is different, and only microcrystalline cellulose is added. Other aspects are the same as Example 3.

[0073] Comparative Example 2

[0074] The difference from Example 3 is that the component ratio of the thickener is different, and the mass ratio of propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1:1:1, that is:

[0075]

[0076] The rest is the same as Example 3.

[0077] Comparative Example 3

[0078] The difference from Example 3 is that the type of plant essential oil is different, and only lemon eucalyptus oil is added. Other aspects are the same as Example 3.

[0079] Comparative Example 4

[0080] The difference from Example 3 is that the component ratio of the plant essential oils is different, and the mass ratio of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 10:1:1:3, that is:

[0081]

[0082] Effect test:

[0083] 1. Irritation test

[0084] Take 40 adult, healthy rabbits with no skin damage and divide them into 10 groups, 4 rabbits in each group; try the mosquito repellent ointment prepared in Examples 1-3 and Comparative Examples 1-4 (as the test substance) respectively. 24 hours before the test, cut off the hair on both sides of the rabbit's spine on the back, without damaging the epidermis. The hair removal range is 3cm×3cm on the left and right, and the application area is 2.5cm×2.5cm. Take 0.5g of the test substance and apply it on the left side of the skin, and apply an equal amount of distilled water on the right side as a control. Apply once a day for 14 consecutive days. Starting from the second day, the hair should be removed before each application, and the residual test substance should be removed with warm water. Observe the skin irritation reaction after one hour and score and judge the irritation according to the "Cosmetic Safety Technical Specifications" (2015 edition).

[0085] The test results showed that the reaction score of the mosquito repellent ointments prepared in Examples 1-3 and Comparative Examples 1-4 was 0.00, indicating that they were non-irritating. This result indicates that the mosquito repellent ointments prepared in Examples 1-3 and Comparative Examples 1-4 were non-irritating, indicating that the raw materials used were all safe.

[0086] 2. Mosquito repellent effect test

[0087] 1. Test materials: Examples 1-3, Comparative Examples 1-4;

[0088] 2. Test subjects: Test insects: Aedes albopictus, adults that have not fed blood for 4 days after emergence, half male and half female; reared indoors; rearing conditions: temperature (26±1)°C, relative humidity (65±5)%;

[0089] Testers: 14 test personnel with qualified attack capabilities.

[0090] 3. Test method: The mosquito repellent effect test was conducted using the method specified in GB / T 13917.9-2009, “Indoor efficacy testing and evaluation of public health insecticides for registered pesticides – Part 9: Repellents.”

[0091] Mosquito Attack Test: 300 mosquitoes were placed in a mosquito cage measuring 40cm x 30cm x 30cm (length x width x height). The subject's arm was exposed with a 4cm x 4cm skin area, while the rest of the arm was covered. The subject's arm was placed in the cage for 2 minutes. The number of mosquitoes that landed was recorded. A test with more than 30 mosquitoes was considered to have acceptable attack capacity, and the subject and the cage could be used in the repellent test.

[0092] Repellency test: 7 subjects with qualified attack ability were selected and a 4cm×4cm skin area was exposed on each of their arms as described above. One arm was set as a blank control without any application, and the exposed part of the other arm was sprayed with 1.5μg / cm 2Apply the test substance evenly at a dose of 100 mg / kg. Rinse thoroughly with clean water and place your arm into a mosquito cage with acceptable attack power for 2 minutes. Observe for mosquitoes that come to feed on your blood. Repeat the test every hour thereafter. If mosquitoes come to feed on your blood, the repellent is deemed ineffective. Record the effective protection time (hours). Repeat this test five times per person per instance.

[0093] Effective protection rate test: 7 subjects with qualified attack capacity were selected and exposed to 4cm × 4cm skin area on both arms as described above. One arm was set as a blank control without any application, and the exposed part of the other arm was treated with 1.5μg / cm 2 Apply the test substance evenly at a dose of 100 mg / kg. Rinse thoroughly with clean water, allow the hand to rest for 10 hours, and then place the hand in the cage for 100 seconds. Repeat this five times per person per instance. Calculate the effective protection rate (%) based on the number of Aedes albopictus mosquitoes that land on the arm.

[0094] Effective protection rate (%) = [(average number of stings in the control group - average number of stings in the experimental group) / average number of stings in the control group] × 100.

[0095] The test results are shown in Table 1 below.

[0096] Table 1

[0097]

[0098] The test results in Table 1 above show that the mosquito repellent shower ointment of the present invention has an effective protection duration of over 8 hours, with a 10-hour effective protection rate of over 78%. The test results of Comparative Examples 1-2 show that the type and ratio of the thickener in the mosquito repellent shower ointment has no significant effect on the effective protection duration, but significantly reduces the effective protection rate after 10 hours, indicating that the type of thickener affects the ointment's long-lasting mosquito repellent effect. The test results of Comparative Examples 3-4 show that the plant essential oils in the mosquito repellent shower ointment interact with each other, and the specific composition and mass ratio of the essential oils have a significant impact on the effective protection duration, but the 10-hour effective protection rate can still reach over 70%.

[0099] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A mosquito repellent shower ointment containing a natural plant mosquito repellent extract, characterized by: The composition comprises the following components by weight percentage: thickener 1.5-3%, solubilizer 15-25%, plant essential oil 40-50%, emulsifier 0.2-0.5%, chelating agent 0.1-0.3%, antioxidant 0.1-0.5%, preservative 0.5-1.5%, sustained-release agent 0.3-0.8% and the balance water; The thickener is a mixture of propylene glycol alginate, sodium alginate and microcrystalline cellulose; the mass ratio of the propylene glycol alginate, sodium alginate and microcrystalline cellulose is 1-3:1-3:5-10; The plant essential oil is a mixture of lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil; the mass ratio of the lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 5-10:3-5:3-5:1-2.

2. The mosquito repellent shower ointment according to claim 1, characterized in that: The composition includes the following components by weight percentage: 2-2.5% thickener, 18-20% solubilizer, 42-50% plant essential oil, 0.3-0.4% emulsifier, 0.2-0.3% chelating agent, 0.2-0.3% antioxidant, 0.8-1.2% preservative, 0.4-0.6% sustained-release agent and 30-40% water.

3. The mosquito repellent shower ointment according to claim 1, characterized in that: The mass ratio of the propylene glycol alginate, sodium alginate and microcrystalline cellulose is 2:2:

8.

4. The mosquito repellent shower ointment according to claim 1, characterized in that: The mass ratio of the lemon eucalyptus oil, rosemary essential oil, lavender essential oil and clove essential oil is 8:4:4:

2.

5. The mosquito repellent shower ointment according to claim 1, characterized in that: The emulsifier is microcrystalline wax; the chelating agent is disodium EDTA; the solubilizer is glycerin; the antioxidant is a mixture of tocopherol and ascorbic acid; the preservative is a mixture of phenoxyethanol and sodium benzoate; and the sustained-release agent is silica.

6. The mosquito repellent shower ointment according to claim 5, characterized in that: The composition includes the following components by weight percentage: 0.4% propylene glycol alginate, 0.4% sodium alginate, 1.6% microcrystalline cellulose, 20% glycerin, 20% lemon eucalyptus oil, 10% rosemary essential oil, 10% lavender essential oil, 5% clove essential oil, 0.3% microcrystalline wax, 0.2% disodium EDTA, 0.1% tocopherol, 0.1% ascorbic acid, 0.5% phenoxyethanol, 0.5% sodium benzoate, 0.5% silica and the balance water.

7. The method for preparing the mosquito repellent shower ointment according to any one of claims 1 to 6, characterized in that: The steps include: (1) Mix and disperse the plant essential oil and the sustained-release agent for 3-5 minutes to obtain solution 1; (2) Mix part of the thickener, solubilizer, and preservative and disperse for 3-5 minutes to obtain solution 2; (3) Add the remaining thickener and preservative to water, stir evenly, and heat to 80-90°C. After complete dissolution, keep the temperature constant for 10-20 minutes to obtain a mixed solution; (4) Add the chelating agent and emulsifier to the mixed solution and continue to stir at a constant temperature for 3-5 minutes, then cool it to 60-70°C, add solution 1 and solution 2, stir at a constant temperature for 3-5 minutes, then cool it to 40-50°C, add the antioxidant, continue to stir for 10-15 minutes, pour it into a mold and cool it to obtain the mosquito repellent shower ointment.

8. Use of the mosquito repellent shower ointment according to any one of claims 1 to 6 in the preparation of a shower filter element.

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