Gel compound for muscle spasm and preparation method and application thereof

Abstract

The invention discloses a gel compound for muscle spasm and a preparation method and application thereof, and the gel compound comprises the following components in percentage by weight: 45%-55% of an active component, 10%-15% of an emollient, 2%-4% of an emulsifier, 1%-1.5% of a thickening agent and the balance of water, wherein the active ingredients comprise 12%-16% of sodium bicarbonate, 10%-14% of peptides, 1%-3% of magnesium chloride, 6%-8% of sodium citrate, 2%-4% of sodium lactate, 4%-6% of magnesium glycinate, 0.5%-1.5% of menthyl lactate, 0.5%-1.5% of menthol, 0.1%-0.3% of hyaluronic acid and 4%-6% of urea. The gel compound has the efficacy of relieving muscle spasm and pain through the synergistic effect of multiple active ingredients, the skin feeling is comfortable, the stability is excellent, and lasting and effective treatment support is provided for patients.

Description

Technical Field

[0001] The invention relates to a gel compound for treating muscle spasm and a preparation method and application thereof, belonging to the technical field of gel compounds. Background Art

[0002] Muscle spasms are a common health problem that can cause great distress to patients’ daily lives. Muscle spasms can not only cause severe pain and discomfort, but can also affect patients’ mobility and quality of life.

[0003] However, existing gel products for relieving muscle spasms have deficiencies in many aspects. First, in terms of skin feel, many products have unreasonable formula design, which makes the skin feel greasy or dry after use, affecting the patient's experience. Secondly, in terms of gel forming, some products are prone to stratification, water precipitation or uneven texture due to poor formula stability, which affects the product's use effect and safety. In addition, many products perform poorly in relieving muscle spasms and cannot quickly and effectively relieve patients' pain and discomfort. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art and provide a gel compound for muscle spasm, a preparation method and use thereof. The gel compound uses sodium bicarbonate, sodium citrate, sodium lactate, peptides, magnesium chloride and magnesium glycinate as active ingredients, which have the effect of relieving muscle spasm and pain through synergistic effects, and has a comfortable skin feel and excellent stability, thereby being able to provide patients with long-lasting and effective treatment support.

[0005] To achieve the above object, the present invention is implemented by adopting the following technical solutions:

[0006] In a first aspect, the present invention discloses a gel compound, which comprises the following raw material components, measured by weight percentage of the gel compound: 45% to 55% of an active ingredient, 10% to 15% of an emollient, 2% to 4% of an emulsifier, 1% to 1.5% of a thickener, and the balance of water;

[0007] Among them, calculated by weight percentage of the gel compound, the active ingredients include 12% to 16% sodium bicarbonate, 10% to 14% peptides, 1% to 3% magnesium chloride, 6% to 8% sodium citrate, 2% to 4% sodium lactate, 4% to 6% magnesium glycinate, 0.5% to 1.5% menthyl lactate, 0.5% to 1.5% menthol, 0.1% to 0.3% hyaluronic acid, and 4% to 6% urea.

[0008] Furthermore, in the active ingredient,

[0009] The mass ratio of the sodium bicarbonate, sodium citrate and sodium lactate is (4-5): (2-3): 1;

[0010] The mass ratio of magnesium chloride to magnesium glycinate is 1:(2-3);

[0011] The peptide is L-carnosine;

[0012] The molecular weight of the hyaluronic acid is 500,000 to 1,000,000 Daltons.

[0013] Furthermore, based on the weight percentage of the gel compound, the emollient includes 4% to 6% glycerin, 2% to 4% propylene glycol, and 4% to 6% aloe leaf extract.

[0014] Furthermore, the aloe polysaccharide content in the aloe leaf extract is ≥4000 mg / 100 g, and the water content is ≤7%.

[0015] Furthermore, the emulsifier includes palmityl alcohol and stearyl alcohol; the mass ratio of palmityl alcohol to stearyl alcohol is (1~3):1.

[0016] Furthermore, the thickener includes xanthan gum.

[0017] Furthermore, the gel compound further comprises the following raw material components, measured by weight percentage of the gel compound: 0.1% to 0.3% preservative, 0.1% to 0.5% pH adjuster, 4% to 6% carrier solvent, 0.1% to 0.3% additive, and 0.1% to 0.3% colorant.

[0018] Further, the additive includes essential oil containing silicon-based components, and the silicon-based components include decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane;

[0019] The mass ratio of the decamethylcyclopentasiloxane to the dodecamethylcyclohexasiloxane is (2-4):1.

[0020] In a second aspect, the present invention discloses a method for preparing the gel compound according to the first aspect, comprising the following steps:

[0021] After heating water to 70-75°C, add an emulsifier and stir until completely melted, then add an emollient and stir evenly at a speed of 500-700 rpm to obtain substance 1;

[0022] Stirring the substance 1 at a speed of 1000-1200 rpm, adding a thickener, and stirring until the viscosity is 20000-30000 cP to obtain a substance 2;

[0023] The temperature of the substance 2 is lowered to 30-35° C., and active ingredients are added in sequence. After each addition of active ingredients, the mixture is stirred evenly, and then new active ingredients are added. The mixture is stirred evenly at a speed of 300-500 rpm to obtain a substance 3.

[0024] Various auxiliary materials are added to the substance three in sequence, stirred evenly and then cooled to room temperature to obtain the final gel compound.

[0025] In a third aspect, the present invention discloses use of the gel compound according to the first aspect in preparing a drug for treating muscle spasm diseases.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The gel compound for muscle spasm of the present invention, and its preparation method and use, firstly, sodium bicarbonate, sodium citrate, sodium lactate, peptides, magnesium chloride, and magnesium glycinate are selected as active ingredients, so that the prepared gel compound has the effect of relieving muscle spasm and pain. Secondly, by controlling the composition and addition of emulsifiers and thickeners, the gel formation is promoted while the stability of the gel is improved. Finally, by selecting a specific emollient and combining menthyl lactate, menthol, and hyaluronic acid in the active ingredients, the skin feel of the prepared gel can be greatly improved, and it is comfortable and non-greasy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 The present invention provides a flow chart of a method for preparing a gel compound. DETAILED DESCRIPTION

[0029] The present invention will be further described below in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and cannot be used to limit the protection scope of the present invention.

[0030] This embodiment provides a gel compound, which includes the following raw material components, measured by weight percentage of the gel compound: 45% to 55% of an active ingredient, 10% to 15% of an emollient, 2% to 4% of an emulsifier, 1% to 1.5% of a thickener, and the balance of water;

[0031] Among them, calculated by weight percentage of the gel compound, the active ingredients include 12%~16% sodium bicarbonate, 10%~14% peptides, 1%~3% magnesium chloride, 6%~8% sodium citrate, 2%~4% sodium lactate, 4%~6% magnesium glycinate, 0.5%~1.5% menthyl lactate, 0.5%~1.5% menthol, 0.1%~0.3% hyaluronic acid, and 4%~6% urea.

[0032] The technical concept of the present invention is as follows: first, sodium bicarbonate, sodium citrate, sodium lactate, peptides, magnesium chloride, and magnesium glycinate are selected as active ingredients, so that the prepared gel compound has the effect of relieving muscle spasms and pain. Secondly, by controlling the composition and addition of emulsifiers and thickeners, the gel formation is promoted while the stability of the gel is improved. Finally, by selecting a specific emollient and combining it with menthyl lactate, menthol, and hyaluronic acid in the active ingredients, the skin feel of the prepared gel can be greatly improved, and it is comfortable and non-greasy to use.

[0033] Specifically, among the active ingredients,

[0034] The mass ratio of sodium bicarbonate, sodium citrate and sodium lactate is (4-5): (2-3): 1. The preferred mass ratio of sodium bicarbonate, sodium citrate and sodium lactate is 14:7:3.

[0035] The mass ratio of magnesium chloride to magnesium glycinate is 1:(2-3). The preferred mass ratio of magnesium chloride to magnesium glycinate is 2:5.

[0036] The peptide was L-carnosine; histidine and alanine were not detected, and the loss on drying was 0.14%. It was purchased from Guangdong Mingtong Biotechnology Co., Ltd.

[0037] The molecular weight of hyaluronic acid is 500,000 to 1,000,000 Daltons. The preferred hyaluronic acid molecular weight is 800,000 Daltons, purchased from Zhengzhou Best Food Additive Co., Ltd.

[0038] Sodium bicarbonate, sodium citrate, sodium lactate, peptides, magnesium chloride and magnesium glycinate are selected as active ingredients. Through the synergistic effect between the active ingredients, the prepared gel compound can have the effect of relieving muscle spasms and pain.

[0039] Sodium citrate, sodium bicarbonate and sodium lactate, as electrolytes and acid-base regulators, can not only neutralize acidic metabolites such as lactic acid and reduce muscle fatigue and soreness, but also help maintain the osmotic pressure and acid-base balance of body fluids through their electrolyte properties. They work synergistically to maintain the acid-base balance inside and outside muscle cells and reduce muscle fatigue and soreness caused by lactic acid accumulation.

[0040] Magnesium chloride and magnesium glycinate, as magnesium supplements, work together with sodium ions in the active ingredients to regulate electrolyte balance in cells, reduce muscle tension by reducing the difference in ion concentration and pH changes inside and outside muscle cells, and reduce muscle cramps caused by electrolyte disorders. L-carnosine, as a peptide substance, has antioxidant properties and can work synergistically with other ingredients to reduce the damage to muscle cells caused by free radicals produced during intense exercise or stress, protect cells from oxidative stress, promote cell health and recovery, and thus help relieve muscle cramps.

[0041] In addition, sodium lactate, magnesium chloride and magnesium glycinate can, on the one hand, reduce muscle cramps caused by insufficient energy by improving the energy metabolism of muscle cells, and on the other hand, help promote the synthesis and utilization of adenosine triphosphate in cells, provide energy for muscle contraction and relaxation. These ingredients work synergistically to improve the energy supply and utilization efficiency of muscle cells, which helps to relax muscles and relieve cramps. The content of each raw material must be strictly controlled during the actual preparation process. Excessive sodium bicarbonate may cause the pH value of the gel to be too high, thereby irritating the skin or causing discomfort. Excessive addition of magnesium chloride and magnesium glycinate may cause the osmotic pressure of the gel to be too high, causing irritation or dehydration to the skin, causing allergic reactions such as skin redness, swelling and itching. Excessive addition of sodium citrate may make the gel too acidic, irritating the skin, and may also react adversely with other ingredients in the formula, affecting the overall performance of the gel. Excessive addition of sodium lactate may make the gel too viscous, affecting the user experience. Excessive L-carnosine may cause phase separation in the gel system, which not only affects the stability and use effect of the gel, but may also form precipitation or crystals in the gel, affecting the appearance of the gel.

[0042] Calculated by weight percentage of the gel compound, the emollient includes 4% to 6% glycerin, 2% to 4% propylene glycol, and 4% to 6% aloe leaf extract.

[0043] The aloe polysaccharide content in the aloe leaf extract is ≥4000 mg / 100 g, and the moisture content is ≤7%, which was purchased from Zhengzhou Givaudan Chemical Products Co., Ltd.

[0044] Furthermore, the emulsifier includes palmityl alcohol and stearyl alcohol, and the mass ratio of palmityl alcohol to stearyl alcohol is (1-3):1; more preferably, it is 2:1.

[0045] Further, the thickener includes xanthan gum. The shear performance value of xanthan gum is 7.6, the pH value of 1% xanthan gum aqueous solution is 7.2, and the viscosity of xanthan gum at 1% mass fraction in 1% KCl solution is 1370 mPa·s. Xanthan gum is purchased from Guangzhou Huayu Biotechnology Co., Ltd.

[0046] Furthermore, the gel compound also includes the following raw material components, based on the weight percentage of the gel compound: 0.1% to 0.3% preservative, 0.1% to 0.5% pH adjuster, 4% to 6% carrier solvent, 0.1% to 0.3% additive, and 0.1% to 0.3% colorant.

[0047] Among them, the preservative is one or more of phenoxyethanol, caprylhydroxamic acid, and 1,2-hexanediol; and further preferred preservatives are caprylhydroxamic acid and 1,2-hexanediol.

[0048] The mass ratio of octanoylhydroxamic acid to 1,2-hexanediol is 1:(4-6). A further preferred mass ratio of octanoylhydroxamic acid to 1,2-hexanediol is 1:5.

[0049] The pH adjuster was citric acid.

[0050] The carrier solvent was diethylene glycol ethyl ether.

[0051] The additives include essential oils containing silicon-based components. The essential oils are not specifically limited, and any essential oils sold on the market can be used, including but not limited to sandalwood essential oil, coconut essential oil, rose essential oil, magnolia essential oil, and orange essential oil. Silicon-based components include decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane;

[0052] The mass ratio of decamethylcyclopentasiloxane to dodecamethylcyclohexasiloxane is (2~4):1.

[0053] By selecting specific emollients and silicon-based ingredients, and combining them with menthyl lactate, menthol, and hyaluronic acid in the active ingredients, the skin feel of the prepared gel can be greatly improved, and it is comfortable and non-greasy to use. This may be because menthyl lactate, menthol, and hyaluronic acid work together to not only deeply moisturize the skin and enhance the skin's barrier function, but also provide a cooling sensation, which helps to relieve muscle pain and discomfort. The synergistic effect of the two silicon-based ingredients, hyaluronic acid, and three specific emollients in a specific ratio allows the prepared gel to not only deeply moisturize and effectively maintain the moisture of the skin after being applied to the skin, but also increase the volatility of the gel, so that the part of the gel remaining on the skin can evaporate quickly, leaving no residue on the skin, making the skin feel particularly moisturized, refreshing, and non-greasy, greatly improving the user experience.

[0054] Decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane have similar structures but are still different. This property enables them to attract and arrange each other in the gel system, forming a more stable and orderly structure, which helps to improve the moisturizing performance and skin feel of the gel. In the actual formula, the amount of each raw material added needs to be strictly controlled. Although hyaluronic acid, glycerin and propylene glycol have moisturizing and hydrating effects, excessive amounts will make the gel feel greasy and affect the user experience; aloe leaf extract is a plant extract, and excessive amounts will affect the stability of the gel; excessive amounts of menthyl lactate and menthol will make the gel feel too cool and cause skin discomfort; excessive amounts of silicone-based ingredients may make the gel texture too thick, which is not conducive to application and uniform distribution.

[0055] There is no specific limitation on the colorant, and any colorant sold on the market can be used, including but not limited to red, blue, yellow, green, orange, and purple.

[0056] like Figure 1 As shown, the preparation method of the gel compound comprises the following steps:

[0057] S1. Heat water to 70-75°C, add emulsifier and stir until completely melted, then slowly add emollient and stir at medium speed for 15-20 minutes until evenly stirred to obtain substance 1;

[0058] S2, stirring substance 1 at high speed, adding thickener at the same time, stirring until the viscosity is 20000~30000 cP, to obtain substance 2;

[0059] S3, lowering the temperature of substance 2 to 30-35°C, adding active ingredients in sequence, stirring evenly after each addition of active ingredients, and then adding new active ingredients, stirring evenly at a low speed to obtain substance 3;

[0060] S4. Add pH adjuster to substance 3, stir evenly, add additives and stir for 5 to 10 minutes, add carrier solvent, stir at medium speed for 5 to 10 minutes to obtain a gel mixture.

[0061] S5. Add colorant and preservative to the gel mixture, stir at low speed for 5 to 10 minutes, and then cool to room temperature to obtain the final gel compound.

[0062] The speed of medium-speed stirring is 500-700 rpm, the speed of high-speed stirring is 1000-1200 rpm, and preferably, the speed of low-speed stirring is 300-500 rpm.

[0063] Selecting specific emulsifiers, thickeners and carrier solvents, and adding them in the order of the present invention and controlling the speed during the preparation process can promote gel formation while improving the stability of the gel. This may be because the two specific emulsifiers work synergistically, can reduce interfacial tension, enhance emulsification performance and stabilize the crystal structure, thereby significantly improving the stability of the gel, preventing the occurrence of phenomena such as stratification and water precipitation, and the stable gel system makes its texture more delicate and uniform, easy to apply and absorb, and increases the overall efficacy of the gel product. First, the emulsifier is evenly dispersed in water to form an emulsion to prevent the active ingredients and oily ingredients from precipitating in the gel, thereby maintaining the transparency and uniformity of the gel; then xanthan gum is added as a thickener and forms a network structure or polymer chain in the solution, increasing the viscosity of the system to stabilize the sol and promote gelation; finally, a specific carrier solvent is added, whose good solubility and volatility not only provide the necessary reaction environment and solubility for the gelation reaction, but also help to form a uniform and transparent gel matrix, so that the sol is gradually transformed into a gel. The synergistic effect of the emulsifier, thickener and carrier solvent ensures the uniformity, stability and transparency of the gel. However, too much thickener may cause the gel to become opaque, affecting its sensory experience and stability. If the addition order and rotation speed of the present invention are changed, the emulsion and gel structure may be unstable and uneven, thereby affecting the transparency, stability, formability, etc. of the prepared gel.

[0064] Example 1

[0065] This embodiment 1 provides a gel compound, which includes the following raw material components, measured by weight percentage of the gel compound: 50.2% active ingredient, 13% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and water to make up the balance to 100%.

[0066] Calculated by weight percentage of the gel compound, the active ingredients include 14% sodium bicarbonate, 12% peptides, 2% magnesium chloride, 7% sodium citrate, 3% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0067] The peptide is L-carnosine.

[0068] By weight percentage of the gel compound, the emollients include glycerin 5%, propylene glycol 3%, and aloe leaf extract 5%.

[0069] The emulsifiers are palmityl alcohol and stearyl alcohol, and the mass ratio of palmityl alcohol to stearyl alcohol is 2:1.

[0070] The thickener is xanthan gum.

[0071] The preservatives are octanoyl hydroxamic acid and 1,2-hexanediol, and the mass ratio of octanoyl hydroxamic acid to 1,2-hexanediol is 1:5.

[0072] The pH adjuster was citric acid.

[0073] The carrier solvent was diethylene glycol ethyl ether.

[0074] The additive is an essential oil containing a silicon-based component. The essential oil is coconut essential oil. The silicon-based components are decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane. The mass ratio of decamethylcyclopentasiloxane to dodecamethylcyclohexasiloxane is 3:1.

[0075] The colorant is red; CAS number is 4548-53-2.

[0076] The preparation method of the gel for relieving muscle spasms comprises the following steps:

[0077] S1. Heat water to 72°C, add emulsifier and stir to ensure that it is completely melted, then slowly add emollient and stir at medium speed for 18 minutes to obtain substance 1;

[0078] S2, stirring substance 1 at high speed, adding thickener at the same time, stirring until the viscosity reaches 25000 cP, to obtain substance 2;

[0079] S3, lowering the temperature of substance 2 to 32°C, adding active ingredients in sequence, ensuring thorough mixing after each addition, and stirring at a low speed for 12 minutes to obtain substance 3;

[0080] S4, adding a pH adjuster to substance 3, stirring evenly, adding an additive and stirring for 8 minutes, adding a carrier solvent, stirring at a medium speed for 8 minutes, and obtaining a gel mixture;

[0081] S5. Add colorant and preservative to the gel mixture, stir at low speed for 8 minutes, and then cool to room temperature.

[0082] The speed of medium-speed stirring was 600 rpm.

[0083] The rotation speed of the high-speed stirring was 1100 rpm.

[0084] The rotation speed of the low-speed stirring was 400 rpm.

[0085] Example 2

[0086] This embodiment 2 provides a gel compound, the raw material components of which are the same as those of embodiment 1, and the preparation method is the same as that of embodiment 1 except for the stirring speed. The specific differences are as follows:

[0087] The speed of medium-speed stirring was 700 rpm.

[0088] The rotation speed of the high-speed stirring was 1200 rpm.

[0089] The rotation speed of low-speed stirring was 300 rpm.

[0090] Example 3

[0091] This Example 3 provides a gel compound, whose raw material components are the same as those of Example 1 except for the ratio of active ingredients, and the preparation method is exactly the same as that of Example 1.

[0092] Specifically, the active ingredients of Example 3 include 13% sodium bicarbonate, 12% peptides, 2% magnesium chloride, 8% sodium citrate, 3% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0093] Comparative Example 1

[0094] Comparative Example 1 provides a gel compound, which is different from Example 1 in that, based on the weight percentage of the gel compound, the gel compound includes the following raw material components: 54.2% of active ingredient, 13% of emollient, 3% of emulsifier, 1.2% of thickener, 0.2% of preservative, 0.3% of pH adjuster, 5% of carrier solvent, 0.2% of additive, 0.2% of colorant, and water supplementing the balance to 100%.

[0095] Calculated by weight percentage of the gel compound, the active ingredients include 18% sodium bicarbonate, 12% peptides, 2% magnesium chloride, 7% sodium citrate, 3% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0096] Comparative Example 2

[0097] Comparative Example 2 provides a gel compound, which is different from Example 1 in that, based on the weight percentage of the gel compound, the gel compound includes the following raw material components: 56.2% active ingredient, 13% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and water to make up the balance to 100%.

[0098] Calculated by weight percentage of the gel compound, the active ingredients include 14% sodium bicarbonate, 18% peptides, 2% magnesium chloride, 7% sodium citrate, 3% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0099] Comparative Example 3

[0100] Comparative Example 3 provides a gel compound, which is different from Example 1 in that, based on the weight percentage of the gel compound, the gel compound includes the following raw material components: 53.2% active ingredient, 13% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and water to make up the balance to 100%.

[0101] Calculated by weight percentage of the gel compound, the active ingredients include 14% sodium bicarbonate, 12% peptides, 2% magnesium chloride, 7% sodium citrate, 6% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0102] Comparative Example 4

[0103] Comparative Example 4 provides a gel compound, which is different from Example 1 in that, based on the weight percentage of the gel compound, the gel compound includes the following raw material components: 53.2% active ingredient, 13% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and water to make up the balance to 100%.

[0104] Calculated by weight percentage of the gel compound, the active ingredients include 14% sodium bicarbonate, 12% peptides, 5% magnesium chloride, 7% sodium citrate, 3% sodium lactate, 5% magnesium glycinate, 1% menthyl lactate, 1% menthol, 0.2% hyaluronic acid, and 5% urea.

[0105] Comparative Example 5

[0106] Comparative Example 5 provides a gel compound, which is different from Example 1 in that, based on the weight percentage of the gel compound, the gel compound includes the following raw material components: 50.2% active ingredient, 13% emollient, 3% emulsifier, 2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and water to make up the balance to 100%.

[0107] Comparative Example 6

[0108] The difference between this comparative example 6 and example 1 is that the preparation method of the gel compound comprises the following steps:

[0109] S1. After heating water to 72°C, add the emulsifier and stir to ensure that it is completely melted, then slowly add the emollient while stirring at a low speed for 18 minutes to obtain substance 1;

[0110] S2, stirring substance 1 at high speed, adding thickener at the same time, stirring until the viscosity reaches 25000 cP, to obtain substance 2;

[0111] S3, lowering the temperature of substance 2 to 32°C, adding active ingredients in sequence, ensuring thorough mixing after each addition, and stirring at a low speed for 12 minutes to obtain substance 3;

[0112] S4, adding a pH adjuster to substance 3, stirring evenly, adding an additive and stirring for 8 minutes, adding a carrier solvent, stirring at a low speed for 8 minutes, and obtaining a gel mixture;

[0113] S5. Add colorant and preservative to the gel mixture, stir at a low speed for 8 minutes, and then cool to room temperature to obtain the final gel compound.

[0114] Comparative Example 7

[0115] The difference between this comparative example 7 and example 1 is that the preparation method of the gel compound comprises the following steps:

[0116] S1. Heat water to 72°C, add emulsifier and stir to ensure that it is completely melted, then slowly add emollient and stir at medium speed for 18 minutes to obtain substance 1;

[0117] S2, stirring substance 1 at high speed, adding a thickener and a carrier solvent, stirring until the viscosity reaches 25000 cP, to obtain substance 2;

[0118] S3, lowering the temperature of substance 2 to 32°C, adding active ingredients in sequence, ensuring thorough mixing after each addition, and stirring at a low speed for 12 minutes to obtain substance 3;

[0119] S4, adding a pH adjuster to substance 3, stirring evenly, adding an additive and stirring at a medium speed for 8 minutes to obtain a gel mixture;

[0120] S5. Add colorant and preservative to the gel mixture, stir at a low speed for 8 minutes, and then cool to room temperature to obtain the final gel compound.

[0121] Comparative Example 8

[0122] The difference between this comparative example 8 and example 1 is that the emulsifier is palmityl alcohol.

[0123] Comparative Example 9

[0124] The difference between this comparative example 9 and example 1 is that, in terms of weight percentage of the gel compound, the gel compound includes the following raw material components: 50.2% active ingredient, 18% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and the balance is supplemented with water to 100%.

[0125] In terms of weight percentage of the gel compound, the emollient includes 10% glycerin, 3% propylene glycol, and 5% aloe leaf extract.

[0126] Comparative Example 10

[0127] The difference between this comparative example 10 and example 1 is that, in terms of weight percentage of the gel compound, the gel compound includes the following raw material components: 50.2% active ingredient, 18% emollient, 3% emulsifier, 1.2% thickener, 0.2% preservative, 0.3% pH adjuster, 5% carrier solvent, 0.2% additive, 0.2% colorant, and the balance is supplemented with water to 100%.

[0128] Calculated by weight percentage of the gel compound, the emollient includes glycerin 5%, propylene glycol 3%, and aloe leaf extract 10%.

[0129] Performance Testing

[0130] With reference to the method in QB / T 2874-2007 "Skin Care Gel", the heat and cold resistance of the prepared gel was tested. The gel was placed at (40±1)℃ and (-10±1)℃ for 24 hours and then returned to room temperature. The appearance before and after the test was observed to see if there was a significant difference. If there was no difference, it was qualified. The gel samples were provided to patients who had continuous muscle cramps in the calves, neck, waist, etc. after fatigue for a 4-week use experience. Ten patients aged 20 to 50 years old were randomly selected for each sample. They were both male and female. After daily cleaning of the muscle spasm area, they were applied twice in the morning and evening according to their own habits. After use, the volunteers scored according to the evaluation indicators. The refreshing feeling was scored from low to high with a score of 0 to 10 points. The more refreshing and non-sticky, the higher the score. The effect of relieving muscle spasms was scored from low to high with a score of 0 to 10 points. The better the relief effect, the higher the score. The soothing score was 0 to 10 points. The more soothing and non-irritating, the higher the score. The scores were rounded to integers, and the average score of 10 people was finally taken. The results are shown in Table 1.

[0131] Table 1 Measurement results

[0132]

[0133] According to statistics, the gel for relieving muscle spasm prepared by Examples 1 to 3 of the present invention has high stability, good cold and heat resistance, and refreshing and non-greasy skin feel, effectively relieving pain and discomfort caused by muscle spasm, and soothing without irritation. In comparative example 1, sodium bicarbonate is added excessively, in comparative example 2, peptides are added excessively, in comparative example 3, sodium lactate is added excessively, in comparative example 4, magnesium chloride is added excessively, in comparative example 5, thickener is added excessively, in comparative example 6, the stirring rate of step S1 and step S4 is too slow, in comparative example 7, the carrier solvent is not added in step S4, in comparative example 8, stearyl alcohol is not added as an emulsifier, in comparative example 9, glycerol is added excessively, in comparative example 10, aloe leaf extract is added excessively, and the prepared gel has poor stability, skin feel, muscle spasm relief, and soothing performance. Therefore, the gel for relieving muscle spasm prepared by the raw materials and methods of the present application can not only effectively relieve the pain and discomfort caused by muscle spasm, but also has refreshing and non-greasy skin feel, ensuring the comfort of long-term use. At the same time, the product has excellent stability, ensuring that its performance can be maintained under various conditions, providing patients with long-lasting and effective treatment support.

[0134] If the specific conditions are not specified in the examples, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer. If the manufacturers of the reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0135] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

[0136] For the purpose of this specification and the appended claims, unless otherwise stated, all numbers expressing amounts, percentages or ratios and other numerical values ​​used in this specification and the appended claims are understood to be modified in all cases by the term "about". In addition, all ranges disclosed herein are inclusive and independently combinable.

[0137] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A gel compound, characterized in that: The gel compound comprises the following raw material components in terms of weight percentage: 45% to 55% of active ingredient, 10% to 15% of emollient, 2% to 4% of emulsifier, 1% to 1.5% of thickener and the balance of water; Among them, calculated by weight percentage of the gel compound, the active ingredients include 12% to 16% sodium bicarbonate, 10% to 14% peptides, 1% to 3% magnesium chloride, 6% to 8% sodium citrate, 2% to 4% sodium lactate, 4% to 6% magnesium glycinate, 0.5% to 1.5% menthyl lactate, 0.5% to 1.5% menthol, 0.1% to 0.3% hyaluronic acid, and 4% to 6% urea.

2. The gel compound according to claim 1, characterized in that: Among the active ingredients, The mass ratio of the sodium bicarbonate, sodium citrate and sodium lactate is (4-5): (2-3): 1; The mass ratio of magnesium chloride to magnesium glycinate is 1:(2-3); The peptide is L-carnosine; The molecular weight of the hyaluronic acid is 500,000 to 1,000,000 Daltons.

3. The gel compound according to claim 1, characterized in that: Calculated by weight percentage of the gel compound, the emollient includes 4% to 6% glycerin, 2% to 4% propylene glycol, and 4% to 6% aloe leaf extract.

4. The gel compound according to claim 3, characterized in that: The aloe polysaccharide content in the aloe leaf extract is ≥4000 mg / 100 g, and the water content is ≤7%.

5. The gel compound according to claim 1, characterized in that: The emulsifier includes palmityl alcohol and stearyl alcohol; the mass ratio of palmityl alcohol to stearyl alcohol is (1-3):

1.

6. The gel compound according to claim 1, characterized in that: The thickener includes xanthan gum.

7. The gel compound according to claim 1, characterized in that: The gel compound further comprises the following raw material components in percentage by weight of the gel compound: 0.1% to 0.3% preservative, 0.1% to 0.5% pH adjuster, 4% to 6% carrier solvent, 0.1% to 0.3% additive, and 0.1% to 0.3% colorant.

8. The gel compound according to claim 7, characterized in that: The additive includes an essential oil containing a silicon-based component, wherein the silicon-based component includes decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane; The mass ratio of the decamethylcyclopentasiloxane to the dodecamethylcyclohexasiloxane is (2-4):

1.

9. The method for preparing a gel compound according to any one of claims 1 to 8, characterized in that: The following steps are involved: After heating water to 70-75°C, add an emulsifier and stir until completely melted, then add an emollient and stir evenly at a speed of 500-700 rpm to obtain substance 1; Stirring the substance 1 at a speed of 1000-1200 rpm, adding a thickener, and stirring until the viscosity is 20000-30000 cP to obtain a substance 2; The temperature of the substance 2 is lowered to 30-35° C., and active ingredients are added in sequence. After each addition of active ingredients, the mixture is stirred evenly, and then new active ingredients are added. The mixture is stirred evenly at a speed of 300-500 rpm to obtain a substance 3. Various auxiliary materials are added to the substance three in sequence, stirred evenly and then cooled to room temperature to obtain the final gel compound.

10. Use of the gel compound according to any one of claims 1 to 8 in the preparation of a medicament for treating muscle spasm diseases.

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