Test system for verifying transcranial electrical stimulation effect in nuclear magnetic resonance environment

Abstract

The embodiment of the invention provides a test system for verifying a transcranial electrical stimulation effect in a nuclear magnetic resonance environment, the system comprises a brain phantom and an electric field acquisition array arranged on the brain phantom, the brain phantom and the electric field acquisition array are made of non-ferromagnetic materials, and the conductivity of the brain phantom is the same as that of a real brain; the electric field acquisition array comprises a plurality of electrodes, and the electrodes are used for acquiring voltage signals on the brain phantom under the condition that the brain phantom is subjected to transcranial electrical stimulation in a high-field magnetic resonance environment. By adopting the technical scheme provided by the embodiment of the invention, the distribution condition of the electric field in the brain is comprehensively and accurately acquired in a high-field magnetic resonance environment on the premise of not generating invasive injury to the brain of a patient, so that the verification of the transcranial electrical stimulation effect is realized.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of medical technology, and in particular to a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment. Background Art

[0002] Transcranial Electrical Stimulation (tES) is a non-invasive neuromodulation technology that affects the neural activity in the scalp layer of the brain by applying a weak current to the scalp. tES can change the excitability of specific areas of the brain, thereby regulating functions related to these areas, such as cognition, emotion, and motor control. It has been widely used in clinical treatment and scientific research because of its non-invasiveness, simple operation, and low cost. In order to ensure the safety and effectiveness of tES treatment, its effectiveness needs to be verified.

[0003] When verifying the effect of tES treatment, it is necessary to obtain the distribution of the electric field in the brain. There are currently some non-invasive technologies that can be used to verify the effect of tES, such as Magnetic Resonance Imaging (MRI) and computed tomography. However, these methods in the existing technology cannot accurately describe the distribution of the electric field in the brain in a high-field MRI environment. In addition, for the emerging temporal interference deep brain stimulation (tTIS) technology, when it is used in a high-field magnetic resonance environment, due to the influence of the magnetic field on the current path and the stimulation effect, it is impossible to fully capture the complex changes in the electric field in the electromagnetic environment, resulting in the inability to accurately verify the effect of tTIS.

[0004] Therefore, there is an urgent need for a technology that can comprehensively and accurately obtain the distribution of electric fields in the brain under a high-field magnetic resonance environment. Summary of the invention

[0005] In order to overcome the problems existing in the related art, an embodiment of the present application provides a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment.

[0006] According to a first aspect of an embodiment of the present application, a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment is provided, the system comprising: a brain phantom and an electric field acquisition array arranged on the brain phantom, the brain phantom and the electric field acquisition array are made of non-ferromagnetic materials, and the conductivity of the brain phantom is the same as that of a real brain; the electric field acquisition array comprises a plurality of electrodes, and the electrodes are used to collect voltage signals on the brain phantom when the brain phantom is subjected to transcranial electrical stimulation in a high-field magnetic resonance environment.

[0007] Optionally, the electric field collection array comprises a printed circuit board PCB, a plurality of electrodes and wires arranged on the PCB, and the plurality of electrodes are arranged on the PCB at equal intervals;

[0008] One end of the wire is connected to the electrode, and the other end of the wire is used to connect to a voltage collection device.

[0009] Optionally, the distance between any two adjacent electrodes in the electric field collection array is between 3 mm and 20 mm.

[0010] Optionally, for each electrode in the electric field collection array, a plurality of signal collection points are arranged at equal intervals along the extension direction of the electrode, and one of the signal collection points is connected to a wire.

[0011] Optionally, a voltage signal acquisition port is also provided on the PCB;

[0012] One end of the voltage signal acquisition port is connected to the wire, and the other end of the voltage signal acquisition port is used to connect to the voltage acquisition device.

[0013] Optionally, the electric field collection array further includes a shielding structure disposed on the PCB, and the shielding structure includes a conductive film disposed on the upper and lower surfaces of the PCB.

[0014] Optionally, the material of the brain phantom includes any one of the following materials:

[0015] polymeric materials, resins and biocompatible materials;

[0016] and / or,

[0017] The material of the electrode includes any one of the following materials:

[0018] Gold, silver, platinum and silver chloride.

[0019] Optionally, the brain phantom is formed by casting in a brain model shell, the brain model shell is formed by 3D printing based on a three-dimensional digital brain model, and the electric field acquisition array is embedded in the brain phantom;

[0020] The three-dimensional digital brain model is obtained by three-dimensional reconstruction based on magnetic resonance imaging (MRI) image data of cranial brain tissue.

[0021] Optionally, the system further comprises a clamp disposed on the brain phantom, wherein the clamp is used to fix the electric field acquisition array.

[0022] Optionally, the system further comprises a voltage acquisition device, and the voltage acquisition device is used to acquire voltage signals on each electrode in the electric field acquisition array.

[0023] In the embodiment of the present application, a brain phantom with the same conductivity as the real brain is used to collect transcranial electrical stimulation signals, and there is no need to use a real brain, thereby avoiding invasive damage to the patient's brain; in addition, the brain phantom and the electric field acquisition array used for the transcranial electrical stimulation effect test in the present solution are made of non-ferromagnetic materials, so that the system can operate stably in a high-field magnetic resonance environment, avoiding the influence of the high-field magnetic resonance environment, and therefore, the voltage signal of the brain phantom can be accurately collected, that is, the distribution of the electric field in the brain can be obtained; furthermore, in the present solution, when the transcranial electrical stimulation effect test is performed, an electric field acquisition array comprising multiple electrodes is used, which can comprehensively collect electric field distribution data. Therefore, the technical solution provided by the embodiment of the present application can comprehensively and accurately obtain the distribution of the electric field in the brain in a high-field magnetic resonance environment without causing invasive damage to the patient's brain, thereby realizing the verification of the transcranial electrical stimulation effect.

[0024] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments of the present application. It should be understood that for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor.

[0026] Figure 1 A schematic diagram of the structure of a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment provided in an embodiment of the present application;

[0027] Figure 2 A schematic diagram of the structure of an electric field acquisition array in a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment provided in an embodiment of the present application;

[0028] Figure 3 A schematic diagram of the structure of electrodes in a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment provided in an embodiment of the present application. DETAILED DESCRIPTION

[0029] The technical solution of the embodiment of the present application is described below in conjunction with the drawings in the embodiment of the present application.

[0030] The terms used in the following embodiments of the present application are for the purpose of describing specific embodiments, and are not intended to be used as limitations on the technical solutions of the present application. As used in the specification and appended claims of the present application, the singular expressions "a", "an", "said", "above", "the" and "this" are intended to include plural expressions as well, unless there is a clear indication to the contrary in the context.

[0031] It should also be understood that although the terms first, second, etc. may be used to describe a certain type of object in the following embodiments, the object should not be limited to these terms. These terms are used to distinguish the specific implementation objects of this type of object.

[0032] First, the present application embodiment provides a test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment, such as Figure 1 As shown, the system includes a brain phantom 110 and an electric field acquisition array 120 disposed on the brain phantom 110. The brain phantom 110 and the electric field acquisition array 120 are made of non-ferromagnetic materials, and the conductivity of the brain phantom 110 is the same as that of a real brain.

[0033] The electric field acquisition array 120 includes a plurality of electrodes 121 . The electrodes 121 are used to acquire voltage signals on the brain phantom 110 when the brain phantom 110 is subjected to transcranial electrical stimulation in a high-field magnetic resonance environment.

[0034] Exemplarily, the brain phantom 110 is made of non-ferromagnetic material, and the conductivity of the material used to make the brain phantom 110 is the same as the conductivity of the real brain. In this way, by using the brain phantom 110, the changes in the electric field generated by the real brain during transcranial electrical stimulation can be simulated. Therefore, by collecting the voltage signal on the brain phantom, the changes in the electric field on the brain during transcranial electrical stimulation can be analyzed. Among them, a possible implementation method of setting the electric field acquisition array 120 on the brain phantom 110 can be that the electric field acquisition array 120 is embedded in the interior of the brain phantom 110.

[0035] In addition, it should be noted that the brain phantom and electric field acquisition array of the system provided in the embodiment of the present application are made of non-ferromagnetic materials, so that the acquisition system can operate stably in a high-field magnetic resonance environment and avoid interference from the high-field magnetic resonance environment, thereby comprehensively and accurately obtaining the distribution of the electric field in the brain in the high-field magnetic resonance environment, thereby realizing the verification of the effect of transcranial electrical stimulation.

[0036] In the embodiment of the present application, the brain phantom 110 can be any shape, such as cylindrical, elliptical, etc., or, in some embodiments, the brain phantom 110 can also be consistent with the shape and structure of the brain. In specific implementation, the specific shape or structure of the brain phantom 110 can be selected according to actual needs, and the embodiment of the present application does not limit this. It only needs to ensure that the brain phantom 110 is made of non-ferromagnetic material and the conductivity is consistent with the conductivity of the real brain.

[0037] It should be noted that in Figure 1 The above is only an exemplary description of the structure of the test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment, and does not constitute a limitation on the shape of the brain phantom 110 in the present application.

[0038] Exemplarily, the material of the brain phantom includes any one of the following materials: polymer material, resin and biocompatible material.

[0039] The biocompatible material may be polyvinyl alcohol (PVA) or polyurethane (PU). The polymer material and resin may be polylactic acid (PLA) or acrylonitrile-butadiene-styrene (ABS). Of course, when implementing the solution, the polymer material, resin or biocompatible material may also be other specific materials. Here, several usable materials are listed for example only, and are not intended to limit the embodiments of the present application.

[0040] In the embodiments of the present application, the selected materials can simulate the softness and shape of brain tissue and will not be interfered by the high-field magnetic resonance environment, thereby ensuring the reliability of the verification of the transcranial electrical stimulation effect.

[0041] In addition, it should be noted that in the embodiment of the present application, in order to avoid interference from the high-field magnetic resonance environment, the electric field acquisition array 120 is also made of non-ferromagnetic materials, and the electrodes in the electric field acquisition array 120 are required to be made of highly conductive materials.

[0042] Exemplarily, the material of the electrode includes any one of the following materials: gold, silver, platinum and silver chloride.

[0043] Among them, gold has excellent electrical conductivity and biocompatibility, and is suitable for electrodes implanted in the body for a long time. Silver and silver chloride have good electrical conductivity and high compatibility with biological tissues, and are often used in external electrode arrays. Platinum has excellent stability and corrosion resistance, and is particularly suitable for electrical stimulation and signal acquisition. Therefore, in the embodiments of the present application, any one of gold, silver, silver chloride and platinum can be used as the material of the electrode.

[0044] It should be noted that the examples listed here are just several optional materials for the electrodes, and are not intended to limit the embodiments of the present application. When implementing the solution, the electrode material can be selected according to actual needs.

[0045] Exemplarily, the electric field collection array 120 may be a square or rectangular matrix structure, that is, the multiple electrodes included in the electric field collection array 120 are arranged in a square matrix or a rectangular matrix. Of course, the multiple electrodes in the electric field collection array 120 may be arranged uniformly in a square or rectangular matrix, or may be arranged non-uniformly in a square or rectangular matrix. Alternatively, in some embodiments, in addition to being arranged in a square matrix or a rectangular matrix, the electric field collection array 120 may also be arranged in a matrix of any shape such as a circle or a trapezoid.

[0046] The electric field collection array 120 needs to be disposed on the brain phantom 110 . For example, it can be embedded in the brain phantom 110 .

[0047] In order to verify the effect of transcranial electrical stimulation, a high-field nuclear magnetic resonance device can be used to scan the brain phantom, and during the scanning process, the voltage signal on the brain phantom 110 is collected through the electrodes in the electric field collection array 120, so as to obtain the voltage change of the brain phantom 110. In one embodiment, the electrode can be connected to the voltage collection device to collect the voltage signal of the electrode, thereby realizing the collection of the voltage signal of the brain phantom.

[0048] In the embodiment of the present application, a brain phantom with the same conductivity as the real brain is used to collect transcranial electrical stimulation signals, and there is no need to use a real brain, thereby avoiding invasive damage to the patient's brain; in addition, the brain phantom and the electric field acquisition array used for transcranial electrical stimulation signal acquisition in the present solution are made of non-ferromagnetic materials, so that the system can operate stably in a high-field magnetic resonance environment to avoid being affected by magnetic field interference, and therefore, the voltage signal of the brain phantom can be accurately collected, that is, the distribution of the electric field in the brain can be obtained; furthermore, in the present solution, when testing the effect of transcranial electrical stimulation, an electric field acquisition array containing multiple electrodes is used, which can comprehensively collect electric field distribution data. Therefore, the technical solution provided by the embodiment of the present application can comprehensively and accurately obtain the distribution of the electric field in the brain in a high-field magnetic resonance environment without causing invasive damage to the patient's brain, thereby realizing the verification of the effect of transcranial electrical stimulation.

[0049] In one embodiment, the electric field collection array 120 includes a printed circuit board (PCB), a plurality of electrodes and wires arranged on the PCB, and the plurality of electrodes are arranged on the PCB at equal intervals; wherein one end of the wire is connected to the electrode, and the other end of the wire is used to connect to a voltage collection device.

[0050] That is, in the embodiment of the present application, the above-mentioned multiple electrodes are evenly distributed on the PCB.

[0051] Specifically, there are multiple wires, one end of a wire is connected to the electrode, and the other end is connected to the voltage acquisition device, so that the voltage signal on the electrode is transmitted to the voltage acquisition device through the wire, thereby realizing the acquisition of the voltage signal.

[0052] In the present embodiment, the electrodes are connected to the voltage acquisition device by using wires, and the electrodes are in contact with the brain phantom, so that the voltage signal of the brain phantom can be acquired. Therefore, through the above circuit connection, the voltage acquisition device can acquire the voltage signal of the brain phantom.

[0053] In one embodiment, the distance between any two adjacent electrodes in the electric field collection array 120 is between 3 mm and 20 mm.

[0054] Exemplarily, the distance between any two adjacent electrodes can be any value between 3 mm and 20 mm. In the embodiment of the present application, the electrodes in the electric field collection array 120 can be arranged evenly. For this case, a value can be selected in the range of 3 mm to 20 mm as the distance between any two adjacent electrodes according to the actual scene requirements.

[0055] In some embodiments, the multiple electrodes in the electric field acquisition array 120 may also be unevenly distributed. For example, the distribution of electrodes corresponding to different regions in the brain phantom may be set according to different brain regions. That is, the brain phantom may be divided into multiple regions, and different regions correspond to different electrode spacings.

[0056] In the embodiment of the present application, different electrode spacings will result in different resolutions of signal acquisition. In the embodiment of the present application, by setting the electrode spacing within the range of 3 mm to 20 mm, it is possible to ensure the resolution of voltage signal acquisition and avoid signal interference caused by concentrated distribution of electrodes, thereby ensuring the accuracy of voltage signal acquisition and further ensuring the reliability of transcranial electrical stimulation effect verification.

[0057] In one embodiment, in order to simulate the electric field distribution of the brain phantom at different depths, the present application embodiment can use a long strip electrode, and set multiple voltage signal collection sites on each electrode. Therefore, in the present application embodiment, the above-mentioned electrode is a long strip electrode, and for each electrode in the electric field collection array, multiple signal collection points are set at equal intervals along the extension direction of the electrode, and one signal collection point is connected to a wire.

[0058] In another embodiment, for each electrode, the distances between the signal collection points may be unequal. When implementing this solution, the distances between the signal collection points on each electrode and the number of signal collection points may be set according to actual needs.

[0059] Figure 2 A schematic diagram of the structure of the electric field acquisition array provided in an embodiment of the present application is shown. Figure 2 As shown, the electric field acquisition array includes a plurality of electrodes 121, and the plurality of electrodes 121 are evenly distributed, and a plurality of signal acquisition points 122 are provided along the extension direction of each electrode 121, and each signal acquisition point 122 is used to be connected to a voltage acquisition device through a wire, so as to realize the measurement of the voltage signal of the brain phantom.

[0060] It should be noted that, in some implementations, electrodes may be fabricated on a PCB through a metallization process such as deposition, sputtering, laser engraving, or the like.

[0061] In the embodiment of the present application, by setting multiple signal collection points in the extension direction of the long strip electrode to collect voltage signals, it is possible to simulate the electric field distribution of the brain phantom at different depths, thereby ensuring the comprehensiveness of the collected electric field signals and further improving the reliability of the transcranial electrical stimulation verification effect.

[0062] In one implementation, a voltage signal acquisition port is also provided on the PCB of the embodiment of the present application, one end of the voltage signal acquisition port is connected to a wire, and the other end of the voltage signal acquisition port is used to connect to a voltage acquisition device.

[0063] Exemplarily, in order to reduce the number of voltage signal acquisition interfaces provided on the PCB, one voltage signal acquisition interface may be provided for one electrode.

[0064] For ease of understanding, the following will take an electrode as an example to introduce its specific implementation structure. Figure 3 The schematic diagram of the structure of any electrode in the electric field collection array provided in the embodiment of the present application is shown as follows: Figure 3 As shown, for any electrode, a plurality of voltage signal collection points 122 are provided along the extension direction of the length thereof, and each signal collection point 122 is respectively connected to a corresponding wire and connected to a voltage collection device through a voltage signal collection port 123 .

[0065] It should be noted that in Figure 3 In the electrode structure shown, the left side represents the top of the electrode, and the right side represents the bottom of the electrode, at the bottom of the electrode there are provided a board-to-board connector 301 and a position calibration point 302. The board-to-board connector 301 refers to the position for soldering, which is used to solder a relatively high-density analog channel interface.

[0066] For example, the electric field collection array 120 in the embodiment of the present application can be prepared in the following manner: First, use photoresist and ultraviolet lithography equipment to finely carve out electrode lines and connection lines on the PCB. Then, on the PCB that has been photolithography and development, a layer of highly conductive metal layer, such as gold, silver or platinum, is deposited by electroplating technology to construct a solid electrode. Finally, the electrode is connected to the peripheral circuit to ensure that the current can flow smoothly through each electrode to the circuit.

[0067] It should be noted that before preparing the electric field collection array 120 through the above process, the overall size of the electric field collection array, the location of each electrode point and the interface design need to be determined. After completing the above preliminary design, the electric field collection array 120 is prepared using the above preparation process.

[0068] In one embodiment, in order to improve the electromagnetic compatibility and shielding function of the electric field collection array, the electric field collection array further includes a shielding structure disposed on the PCB, and the shielding structure includes conductive films disposed on the upper and lower surfaces of the PCB.

[0069] For example, during the processing of the electric field collection array, a conductive film layer may be added to the upper and lower surfaces of the PCB to achieve the setting of the shielding structure.

[0070] In order to further improve the reliability of the verification of the effect of transcranial electrical stimulation, the above-mentioned brain phantom can be a phantom that is consistent with the shape and structure of the brain. In this case, the above-mentioned brain phantom is formed by casting in the brain model shell, and the brain model shell is formed by 3D printing based on the three-dimensional digital brain model, and the electric field acquisition array is embedded in the brain phantom; the above-mentioned three-dimensional digital brain model is obtained by three-dimensional reconstruction based on the MRI image data of the cranial brain tissue.

[0071] In one embodiment, the MRI image data may include any one or more of T1-weighted imaging data, T2-weighted imaging data, and functional MRI data. Alternatively, in some other embodiments, the MRI image data may also be other types of data, which will not be described in detail here.

[0072] For example, after obtaining the MRI image data, the MRI data is converted into a three-dimensional digital brain model, wherein the conversion of the MRI data into a three-dimensional digital brain model requires a series of processing steps such as image segmentation, three-dimensional model calculation, surface reconstruction, and model smoothing.

[0073] In one embodiment, professional medical image processing software, such as FSL, SPM or FreeSurfer, can be used in combination with an automated segmentation algorithm to divide different brain tissues (such as gray matter, white matter, cerebrospinal fluid, etc.) to obtain brain tissues of various parts of the brain. The automated segmentation algorithm can be an Otsu threshold algorithm or a segmentation algorithm based on machine learning.

[0074] Then, a three-dimensional computing tool or software is used to calculate the three-dimensional model. For example, an open source medical image processing library can be used to calculate the three-dimensional reconstruction model.

[0075] Finally, the surface of the brain tissue is reconstructed based on the three-dimensional model and each part of the brain tissue to generate a three-dimensional mesh model representing the brain structure. Exemplarily, in this step, the model smoothing technology based on the Laplace smoothing algorithm can be used to eliminate noise, thereby improving the accuracy of the model. Further, after the surface reconstruction, the Laplace smoothing algorithm can be used to smooth the above-obtained model to obtain a three-dimensional digital brain model.

[0076] It should be noted that this is only an exemplary example of a possible implementation method for generating a three-dimensional digital brain model, and is not intended to limit the embodiments of the present application. In implementation, other methods may also be used to generate the above three-dimensional digital brain model.

[0077] After obtaining the above-mentioned three-dimensional digital brain model, the brain model shell is made based on the three-dimensional digital brain model through 3D printing technology, that is, the shell of the brain phantom is printed, and then an agar solution or other materials are poured into the brain model shell to obtain the brain phantom. In addition, it should be noted that during the pouring process of the brain model shell, the electric field acquisition array is gradually embedded into the model. Figure 1 Schematic diagram of the structure of an electric field acquisition array embedded in a brain phantom.

[0078] In the embodiment of the present application, the three-dimensional digital brain model can be accurately replicated by adopting 3D printing technology, thereby improving the similarity between the brain phantom and the real brain structure, and further ensuring the reliability of the verification of the effect of transcranial electrical stimulation.

[0079] In one embodiment, the system provided in the embodiment of the present application further includes a clamp disposed on the brain phantom, wherein the clamp is used to fix the electric field acquisition array.

[0080] In the embodiment of the present application, the electric field acquisition array is fixed by using a clamp so that the electric field acquisition array can be stably fixed at a specific position of the brain phantom, thereby ensuring the accuracy of the position of the electric field acquisition array, thereby improving the accuracy of signal acquisition and ensuring the reliability of the verification of the transcranial electrical stimulation effect.

[0081] In the system provided by the embodiment of the present application, the electric field distribution under different electrical stimulation intensities, frequencies and waveforms can be simulated by adjusting parameters, so as to achieve the simulation of the effects of different stimulation schemes on the deep areas of the brain. In the specific implementation, a high-field nuclear magnetic resonance device can be used to scan the brain phantom to simulate the effect of transcranial electrical stimulation under a high-field magnetic resonance environment. Then, simulation software is used to simulate and analyze the changing values ​​of the stimulation waveform and the electric field intensity, and then the experimental data is compared with the simulation results to verify the changing law of the electric field under the action of a high-intensity magnetic field.

[0082] The test system for verifying the effect of transcranial electrical stimulation under a nuclear magnetic resonance environment provided in an embodiment of the present application also includes a voltage acquisition device, which is used to collect voltage signals on each electrode in the electric field acquisition array.

[0083] Although the optional embodiments of the present application have been described, those skilled in the art, once informed of the basic creative concept, may make additional changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiment and all changes and modifications falling within the scope of the present application.

[0084] The specific implementation methods described above further illustrate the purpose, technical solutions and beneficial effects of the present application in detail. It should be understood that the above description is only the specific implementation methods of the present application and is not intended to limit the scope of protection of the present application. Any modifications, equivalent substitutions, improvements, etc. made on the basis of the technical solutions of the present application should be included in the scope of protection of the present application.

Claims

1. A test system for verifying the effect of transcranial electrical stimulation in a nuclear magnetic resonance environment, characterized in that: The system comprises: a brain phantom and an electric field acquisition array arranged on the brain phantom, wherein the brain phantom and the electric field acquisition array are made of non-ferromagnetic materials, and the conductivity of the brain phantom is the same as that of a real brain; The electric field acquisition array includes a plurality of electrodes, and the electrodes are used to acquire voltage signals on the brain phantom when the brain phantom is subjected to transcranial electrical stimulation in a high-field magnetic resonance environment.

2. The system according to claim 1, characterized in that The electric field collection array comprises a printed circuit board PCB, a plurality of electrodes and wires arranged on the PCB, and the plurality of electrodes are arranged on the PCB at equal intervals; One end of the wire is connected to the electrode, and the other end of the wire is used to connect to a voltage collection device.

3. The system according to claim 2, characterized in that The distance between any two adjacent electrodes in the electric field collection array is between 3 mm and 20 mm.

4. The system according to claim 2, characterized in that The electrodes are long strip electrodes. For each electrode in the electric field collection array, a plurality of signal collection points are arranged at equal intervals along the extension direction of the electrode, and one of the signal collection points is connected to a wire.

5. The system according to any one of claims 2 to 4, characterized in that: The PCB is also provided with a voltage signal acquisition port; One end of the voltage signal acquisition port is connected to the wire, and the other end of the voltage signal acquisition port is used to connect to the voltage acquisition device.

6. The system according to any one of claims 2 to 4, characterized in that: The electric field collection array further includes a shielding structure disposed on the PCB, and the shielding structure includes a conductive film disposed on the upper and lower surfaces of the PCB.

7. The system according to any one of claims 1 to 4, characterized in that: The material of the brain phantom includes any one of the following materials: polymeric materials, resins and biocompatible materials; and / or, The material of the electrode includes any one of the following materials: Gold, silver, platinum and silver chloride.

8. The system according to any one of claims 1 to 4, characterized in that: The brain phantom is formed by casting in a brain model shell, the brain model shell is formed by 3D printing based on a three-dimensional digital brain model, and the electric field acquisition array is embedded in the brain phantom; The three-dimensional digital brain model is obtained by three-dimensional reconstruction based on magnetic resonance imaging (MRI) image data of cranial brain tissue.

9. The system according to claim 8, characterized in that The system further comprises a clamp arranged on the brain phantom, wherein the clamp is used to fix the electric field acquisition array.

10. The system according to any one of claims 1 to 4, characterized in that: It also includes a voltage acquisition device, which is used to acquire voltage signals on each electrode in the electric field acquisition array.

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