Method for testing stability of proficiency testing liquid sample and related equipment

Abstract

The invention provides a proficiency testing liquid sample stability testing method and related equipment, and relates to the technical field of radionuclide analys.The method comprises the steps that a preset number of to-be-treated liquid samples are randomly extracted from liquid samples, stability testing parameters are determined, the to-be-treated liquid samples are placed in a corresponding testing environment to be treated, and the to-be-treated liquid samples are obtained; the stability test parameters at least comprise temperature, analyzing according to a standard analysis method to obtain a measured average value of the radionuclides, correcting the measured average value to a preset test date according to the half-life period of the radionuclides to obtain a corrected average value, and calculating the stability of the radionuclides according to the corrected average value. And obtaining a stability conclusion of the liquid sample under the stability test parameters. According to the technical scheme, factors influencing the stability of the proficiency testing liquid sample can be tested, the influence of the factors is avoided in the process of analyzing the activity concentration of the radionuclide, and the reliability of the analysis result of the activity concentration of the radionuclide is improved.

Description

Background Art

[0002] Radioactivity is a property of the nucleus itself and will not change with changes in external conditions. For radioactive nuclides in liquid samples, the content of radioactive nuclides will not change.

[0003] However, radionuclides exist in the medium, such as the proficiency testing liquid sample. The quality change of the proficiency testing liquid sample may cause the change of the radionuclide concentration. During the process of analysis, testing, distribution and storage, there may be various reasons that affect the proficiency testing liquid sample, resulting in insufficient stability, thus affecting the concentration of radionuclides and affecting the reliability of the analysis results of radionuclide activity concentration.

[0004] It should be noted that the information disclosed in the above background technology section is only used to enhance the understanding of the background of the present disclosure, and therefore may include information that does not constitute the prior art known to ordinary technicians in the field. Summary of the invention

[0005] The present disclosure provides a liquid sample stability testing method and related equipment, which can at least to some extent test the factors that affect the stability of the proficiency testing liquid sample and solve the problem of reduced reliability of radionuclide activity concentration analysis results due to the stability of the proficiency testing liquid sample.

[0006] Other features and advantages of the present disclosure will become apparent from the following detailed description, or may be learned in part by the practice of the present disclosure.

[0007] The technical solution of the present invention,

[0008] In a first aspect, the present invention provides a method for testing the stability of a liquid sample for proficiency testing, the method comprising the following specific steps:

[0009] S202, randomly extracting a preset number of liquid samples to be processed from the liquid samples;

[0010] S204, determining stability test parameters of the liquid sample to be processed, placing the liquid sample to be processed in a test environment corresponding to the stability test parameters for processing, and obtaining the liquid sample to be tested; the stability test parameters at least include: temperature;

[0011] S206, analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to a standard analysis method to obtain a measured average value of the radioactive nuclides in the preset number of the liquid samples to be tested;

[0012] S208, correcting the measured average value to a preset inspection date according to the half-life of the radionuclide to obtain a corrected average value;

[0013] S210. Obtaining a stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

[0014] Preferably, in step S204, the stability test parameter is determined to be temperature;

[0015] The liquid sample to be processed is placed in an environment with a first preset temperature for a first preset number of days, then placed in an environment with a second preset temperature for a second preset number of days, and restored to normal temperature to obtain a liquid sample to be tested that has undergone temperature testing.

[0016] Preferably, the stability test parameters in step S204 also include: time;

[0017] Determining the stability test parameter as time;

[0018] Placing each of the liquid samples to be processed in an environment within a preset temperature range and a preset humidity range for a target period of time to obtain the liquid samples to be tested after time storage testing;

[0019] Wherein, the target time period includes: a start time node and an end time node;

[0020] The starting time node is: the time node when each of the liquid samples to be processed is placed in an environment within a preset temperature range and a preset humidity range;

[0021] The end time node is: the time node when the liquid sample is distributed to the participant for proficiency testing and the testing result is obtained.

[0022] Preferably, the stability test parameters in step S204 also include: sample packaging;

[0023] Determining the stability test parameter as sample packaging;

[0024] The same sealed package is provided for each of the liquid samples to be processed to obtain a packaged liquid sample; the inspection environment in the sealed package is a conventional environment;

[0025] Each of the liquid samples to be processed is mailed to a preset distance via a delivery order to obtain a liquid sample to be tested.

[0026] Preferably, the stability test parameters include at least: time and sample packaging;

[0027] The method further comprises:

[0028] Obtaining a first stability conclusion in which the stability test parameter is temperature, a second stability conclusion in which the stability test parameter is time, and a third stability conclusion in which the stability test parameter is sample packaging;

[0029] A stability conclusion of the liquid sample is determined based on the first stability conclusion, the second stability conclusion and the third stability conclusion.

[0030] Preferably, step S206 further includes the following steps:

[0031] In the process of analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to the standard analysis method, the radioactive nuclides in each of the liquid samples to be tested are detected in parallel to obtain the measured value of the radioactive nuclides in each of the liquid samples to be tested;

[0032] For each of the liquid samples to be tested, the radioactive nuclide is repeatedly measured for a preset number of times to obtain a measurement value of a total number of measurements; the total number of measurements is the product of the preset number of times and the preset quantity;

[0033] A measurement average value is determined based on the measurement values ​​of the total number of measurements.

[0034] Preferably, step S210 further includes the following steps:

[0035] Determining a statistical value according to the modified average value;

[0036] Get the critical value of stability test;

[0037] If the statistical value is less than the critical value, the stability conclusion of the liquid sample under the stability test parameter is determined to be stable.

[0038] In a second aspect, the present invention provides a capability verification liquid sample stability testing device, which tests the stability of the capability verification liquid sample according to the steps of the above method, including:

[0039] An acquisition unit, used for randomly extracting a preset number of liquid samples to be processed from the liquid samples;

[0040] A processing unit is used to determine the stability test parameters of the liquid sample to be processed, and place the liquid sample to be processed in a test environment corresponding to the stability test parameters to obtain the liquid sample to be tested; the stability test parameters at least include: temperature;

[0041] An analysis and measurement unit, used for analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to a standard analysis method, and obtaining a measurement average value of the radioactive nuclides in the preset number of the liquid samples to be tested;

[0042] A correction unit, used for correcting the measured average value to a preset inspection date according to the half-life of the radionuclide to obtain a corrected average value;

[0043] The output unit is used to obtain the stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

[0044] In a third aspect, the present invention provides an electronic device, comprising:

[0045] Processor; and

[0046] A memory, configured to store executable instructions of the processor;

[0047] The processor is configured to perform the steps of the above method by executing the executable instructions.

[0048] In a fourth aspect, the present invention provides a computer-readable storage medium having a computer program stored thereon, wherein the computer program implements the steps of the above method when executed by a processor.

[0049] In a fifth aspect, the present invention provides a computer program product, comprising: a computer program or instructions, which implement the steps of the above method when executed by a processor.

[0050] Compared with the prior art, the present invention has the following beneficial technical effects:

[0051] The present invention provides a complete and reproducible method for testing the stability of a liquid sample for proficiency testing of radionuclides. The method of the present invention can test factors that affect the stability of a liquid sample for proficiency testing, avoid the influence of these factors during the analysis of the activity concentration of radionuclides, and improve the reliability of the analysis results of the activity concentration of radionuclides. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] The accompanying drawings herein are incorporated into the specification and constitute a part of the specification, illustrate embodiments consistent with the present disclosure, and together with the specification are used to explain the principles of the present disclosure. Obviously, the accompanying drawings described below are only some embodiments of the present disclosure, and for ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without creative work.

[0053] Figure 1 A schematic diagram showing a stability testing system for a proficiency testing liquid sample according to an embodiment of the present disclosure is shown;

[0054] Figure 2 A flow chart showing a method for testing the stability of a liquid sample for capability testing in an embodiment of the present disclosure is shown;

[0055] Figure 3 A schematic diagram showing a method of obtaining a stability conclusion in an embodiment of the present disclosure is shown;

[0056] Figure 4 A flow chart showing a sample processing process in which the stability test parameter is temperature in an embodiment of the present disclosure;

[0057] Figure 5 A flow chart showing a sample processing process in which a stability test parameter is time in an embodiment of the present disclosure;

[0058] Figure 6 A flow chart showing a sample processing process in which a stability test parameter is sample packaging in an embodiment of the present disclosure;

[0059] Figure 7 A schematic diagram showing a stability testing device for a proficiency testing liquid sample according to an embodiment of the present disclosure is shown;

[0060] Figure 8 A schematic diagram of an electronic device in an embodiment of the present disclosure is shown. DETAILED DESCRIPTION

[0061] Example embodiments will now be described more fully with reference to the accompanying drawings. However, example embodiments can be implemented in a variety of forms and should not be construed as limited to the examples set forth herein; rather, these embodiments are provided so that the disclosure will be more comprehensive and complete and to fully convey the concepts of the example embodiments to those skilled in the art. The described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

[0062] In addition, the accompanying drawings are only schematic illustrations of the present disclosure and are not necessarily drawn to scale. The same reference numerals in the figures represent the same or similar parts, and their repeated description will be omitted. Some of the block diagrams shown in the accompanying drawings are functional entities and do not necessarily correspond to physically or logically independent entities. These functional entities can be implemented in software form, or implemented in one or more hardware modules or integrated circuits, or implemented in different networks and / or processor devices and / or microcontroller devices.

[0063] Figure 1 A schematic diagram of a liquid sample stability testing method applicable to a proficiency testing embodiment of the present disclosure is shown.

[0064] like Figure 1 As shown, the proficiency testing liquid sample stability testing system 100 may include a terminal device 101 , a network 102 and a server 103 .

[0065] The network 102 is a medium for providing a communication link between the terminal device 101 and the server 103, and can be a wired network or a wireless network.

[0066] Optionally, the wireless network or wired network described above uses standard communication technology and / or protocol. The network is typically the Internet, but may also be any network, including but not limited to a local area network (LAN), a metropolitan area network (MAN), a wide area network (WAN), a mobile, wired or wireless network, a dedicated network or any combination of a virtual private network). In some embodiments, technologies and / or formats including Hyper Text Mark-up Language (HTML), Extensible Markup Language (XML), etc. are used to represent data exchanged over the network. In addition, conventional encryption technologies such as Secure Socket Layer (SSL), Transport Layer Security (TLS), Virtual Private Network (VPN), Internet Protocol Security (IPsec), etc. may be used to encrypt all or some links. In other embodiments, customized and / or dedicated data communication technologies may also be used to replace or supplement the above data communication technologies.

[0067] The terminal device 101 can be various electronic devices, including but not limited to smart phones, tablet computers, laptop computers, desktop computers, wearable devices, augmented reality devices, virtual reality devices, etc.

[0068] Optionally, the client of the application installed in different terminal devices 101 is the same, or the client of the same type of application based on different operating systems. Based on the different terminal platforms, the specific form of the client of the application can also be different, for example, the application client can be a mobile client, a PC client, etc.

[0069] The server 103 may be a server that provides various services, such as a background management server that provides support for the device operated by the user using the terminal device 101. The background management server may analyze and process the received request and other data, and feed back the processing results to the terminal device.

[0070] Optionally, the server can be an independent physical server, or a server cluster or distributed system composed of multiple physical servers, or a cloud server that provides basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, CDN (Content Delivery Network), and big data and artificial intelligence platforms. The terminal can be a smart phone, tablet computer, laptop computer, desktop computer, smart speaker, smart watch, etc., but is not limited to this. The terminal and the server can be directly or indirectly connected via wired or wireless communication, which is not limited in this disclosure.

[0071] Those skilled in the art will know that Figure 1 The number of terminal devices, networks and servers in the embodiment is only for illustration, and any number of terminal devices, networks and servers may be provided according to actual needs, and the embodiments of the present disclosure do not limit this.

[0072] The present exemplary implementation is described in detail below with reference to the accompanying drawings and embodiments.

[0073] First, a method for testing the stability of a liquid sample for capability verification is provided in an embodiment of the present disclosure. The method can be executed by any electronic device with computing and processing capabilities. In the following process, the electronic device is taken as a terminal device as an example.

[0074] Figure 2 A flow chart of a method for testing the stability of a liquid sample for capability verification in an embodiment of the present disclosure is shown. Figure 2 As shown, the capability verification liquid sample stability test method provided in the embodiment of the present disclosure comprises the following steps:

[0075] S202: Randomly extract a preset number of liquid samples to be processed from the liquid samples.

[0076] In a possible embodiment, the preset number of liquid samples to be processed may be randomly extracted from the original liquid samples.

[0077] In a possible embodiment, the preset number may include multiple types. To facilitate verification, the preset number may be selected as 3.

[0078] In a possible embodiment, the random sampling process may include: taking the existence of k liquid samples as an example, the k liquid samples are numbered sequentially, and an Excel program for generating random numbers may be used to randomly generate 3 random numbers as the numbers of the randomly selected liquid samples.

[0079] In a possible embodiment, the liquid sample may include multiple types, such as water samples, petroleum samples, and mixtures of petroleum and water. The liquid sample is a medium containing radioactive nuclides. The present disclosure does not limit the specific type of the liquid sample, and the following embodiments take water samples as an example.

[0080] The radioactive nuclide is not limited in the present disclosure and may be any radioactive nuclide. The radioactive nuclide strontium-90 is taken as an example in the present disclosure.

[0081] S204: Determine stability test parameters of the liquid sample to be processed, place the liquid sample to be processed in a test environment corresponding to the stability test parameters for processing, and obtain the liquid sample to be tested, wherein the stability test parameters at least include: temperature.

[0082] In a possible embodiment, a stability test is performed on a liquid sample. There are various situations that may affect the stability of the liquid sample. According to the actual situation, the staff can input corresponding stability test parameters during the test process. The terminal device can determine the stability test parameters of the liquid sample to be processed, and perform corresponding processing according to the stability test parameters to obtain the liquid sample to be tested.

[0083] The content of radionuclides remains unchanged, but due to various reasons, the liquid sample will be affected, causing the liquid sample to change, and ultimately causing the concentration of radionuclides to change.

[0084] For example, during transportation, both high and low temperatures may affect the liquid sample, causing the liquid sample to volatilize or other situations.

[0085] For example, in the actual proficiency testing process, if the liquid sample is stored for too long, the stability of the liquid sample will be affected.

[0086] For example, in each proficiency test, the packaging used to store the liquid sample may also affect the liquid sample.

[0087] Among them, different types of liquid samples may have different corresponding stability test parameters.

[0088] For example, for water samples, the stability test parameters may include temperature, time, and sample packaging.

[0089] If the sample is petroleum, the stability test parameters may also include: factors that may affect the stability of the petroleum during transportation.

[0090] In a possible embodiment, the stability test parameter determined by the terminal device may be displayed by the terminal device after determining the type of the liquid sample, and then input by the staff, or may be pre-set according to different types of liquid samples.

[0091] In a possible embodiment, a specific method for determining the stability test parameters of the liquid sample to be processed may also include: according to the target type of the liquid sample, traversing the historical stability test records of the liquid sample of the target type from the database, obtaining a data set of the proficiency verification analysis results of the radionuclide when the liquid sample of the target type is used as a proficiency verification medium for the radionuclide according to the historical stability test records, obtaining the abnormal analysis results of the proficiency verification of the radionuclide from the data set, obtaining a first liquid sample of the target type in the abnormal analysis process corresponding to the abnormal analysis result, and obtaining a second liquid sample of the target type in the normal analysis process corresponding to the normal analysis result, comparing the first liquid sample and the second liquid sample, obtaining the influencing factors of the stability of the first liquid sample, and using the influencing factors as stability test parameters.

[0092] S206: Analyze the radioactive nuclides in a preset number of liquid samples to be tested according to a standard analysis method to obtain a measured average value of the radioactive nuclides in the preset number of liquid samples to be tested.

[0093] In a possible embodiment, the standard analysis method may include a standard analysis method for analyzing radioactive nuclides, for example, it may include: HJ815-2016 standard analysis method, but the present disclosure is not limited thereto.

[0094] In a possible embodiment, for different radionuclides, the corresponding standard analysis methods may also be different.

[0095] In a possible embodiment, a method for obtaining a measurement average value of radioactive nuclides may include: in the process of analyzing the radioactive nuclides in a preset number of liquid samples to be tested according to a standard analysis method, parallel detection of the radioactive nuclides in each liquid sample to be tested is performed to obtain a measurement value of the radioactive nuclides in each liquid sample to be tested; for each liquid sample to be tested, the radioactive nuclides are repeatedly measured a preset number of times to obtain a measurement value of a total number of measurements; the total number of measurements is the product of the preset number of times and the preset number; and the measurement average value is determined based on the measurement value of the total number of measurements.

[0096] There are also many specific ways to analyze and measure radioactive nuclides. The present disclosure uses the α / β counter measurement method as an example, but is not limited to this.

[0097] Among them, the standard analysis methods include specific analysis processes for radioactive nuclides, and the series of analysis processes in the standard analysis methods will not be repeated in this disclosure.

[0098] Through the above standard analysis method, the measurement value of each liquid sample to be tested is obtained. For each liquid sample to be tested, the measurement can be repeated for a preset number of times to obtain the measurement value of the total number of measurements, and the average value is determined.

[0099] The total number of measurements n is the product of the preset number and the preset quantity. In the present disclosure, the preset number can be selected as 2, then n=6.

[0100] Among them, the measured value of the radionuclide is the activity concentration of strontium-90.

[0101] S208: According to the half-life of the radioactive nuclide, the measured average value is corrected to the preset inspection date to obtain a corrected average value.

[0102] In a possible embodiment, the radioactive nuclide has a half-life. After obtaining the measured average value, the measured average value needs to be corrected according to the half-life to a preset inspection date to obtain a corrected average value.

[0103] Exemplarily, if the current date of the measurement average value is September 2, 2024, the preset inspection date can also be understood as a specified date, and the specified date is September 20, 2024. The obtained measurement average value is not on the specified date. It is corrected according to the half-life of the radionuclide to obtain the corrected average value of the radionuclide on September 20, 2024.

[0104] However, the specific modification method is not limited in this disclosure.

[0105] S210: Obtain a stability conclusion of the liquid sample under the stability test parameters based on the corrected average value.

[0106] Through the above-mentioned method, the corresponding stability conclusion of the liquid sample under different stability test parameters can be obtained. When the liquid sample is distributed to the participants for radionuclide analysis, it is ensured that the liquid sample will not have stability problems due to the influence of certain stability test parameters, thereby resulting in insufficient reliability of the radionuclide analysis results. The method disclosed in the present invention can test the stability of the proficiency testing liquid sample, thereby improving the reliability of the radionuclide proficiency testing analysis results, as well as improving the accuracy and credibility of the results.

[0107] In a possible embodiment, in the present disclosure, when performing a stability test on a liquid sample, corresponding stability test parameters can be flexibly selected.

[0108] For example, if the stability test parameter only includes temperature, then only temperature can be selected as the stability test parameter. After the temperature test, if the stability conclusion of the liquid sample is stable, it means that the liquid sample is stable.

[0109] Exemplarily, if the stability test parameters include temperature and time, for example, if the liquid sample may evaporate due to long storage time, then the stability test parameters can be selected as temperature and time. After testing the temperature and time, the stability conclusion of the liquid sample is stable, which means that the liquid sample is stable.

[0110] For example, if the stability test parameters include temperature, time, packaging and other parameters, all of them can be tested, and the stability conclusion corresponding to all stability test parameters corresponding to the liquid sample is stable, which means that the liquid sample is stable.

[0111] In the present disclosure, taking the stability test parameters including temperature, time and sample packaging as an example, the method of determining whether a liquid sample is stable may include: obtaining a first stability conclusion in which the stability test parameter is temperature, a second stability conclusion in which the stability test parameter is time, and a third stability conclusion in which the stability test parameter is sample packaging, and determining the stability conclusion of the liquid sample based on the first stability conclusion, the second stability conclusion and the third stability conclusion.

[0112] Exemplarily, if the first stability conclusion, the second stability conclusion and the third stability conclusion are all stable, then the stability conclusion of the liquid sample is stable.

[0113] For example, if the first stability conclusion and the second stability conclusion are stable, and the third stability conclusion is unstable, then the stability conclusion of the liquid sample is unstable, and it can be concluded that the instability of the liquid sample is caused by the sample packaging, and the sample packaging is improved. For example, during the stability test, the sample packaging is a plastic bag, which is damaged during transportation, causing the liquid sample to leak or seep out, resulting in a change in the quality of the liquid sample. The sample packaging can be improved by replacing it with a stronger packaging to ensure the stability of the liquid sample.

[0114] In a possible embodiment, for a round of proficiency testing, after the liquid samples are distributed to the participants, the remaining liquid samples are used as retained samples. When the retained samples are needed for a second round of proficiency testing and are distributed to the participants again, the retained samples should be retested for stability before being distributed, and samples can be distributed again only after the stability test is passed.

[0115] Among them, for a round of proficiency testing process, when conducting stability testing on liquid samples, before distributing the liquid samples to participants, it is necessary to complete the stability testing process with stability testing parameters such as temperature and sample packaging. For the stability testing process with stability testing parameters such as time, it is necessary to obtain the liquid sample to be tested.

[0116] In one possible embodiment, Figure 3 A flow chart of obtaining a stability conclusion in an embodiment of the present disclosure is shown. Figure 3 As shown, the following steps are included:

[0117] S302: Determine a statistical value according to the corrected mean value.

[0118] S304: Obtain a critical value for stability testing.

[0119] S306: Determine whether the statistical value is less than the critical value, if so, execute S308; if so, execute S310.

[0120] S308: Determine that the stability conclusion of the liquid sample under the stability test parameters is stable.

[0121] S310: Determine that the stability conclusion of the liquid sample under the stability test parameters is unstable.

[0122] In a possible embodiment, there are multiple ways to determine the stability of a sample containing radionuclides based on the measured average value of radionuclides, including: t-test method, xy≤0.3σ criterion method, etc. Among them, the t-test method can include multiple ways, such as: comparing a corrected average value with a standard value / reference value / specified value, or whether there is a significant difference between two corrected average values.

[0123] The specific method adopted can be illustrated by the following embodiments:

[0124] Embodiment 1:

[0125] In the present disclosure, the t-test method can be selected to compare whether there is a significant difference between an average value and a specified value to determine stability.

[0126] Exemplarily, determining the statistical value based on the corrected mean value may include the following steps: obtaining a specified value of the activity concentration of the radionuclide on a preset inspection date, and determining the statistical value based on the corrected mean value and the specified value of the stability inspection.

[0127] Exemplarily, the method of determining the statistical value may include: determining the deviation value based on the corrected mean value of the stability test and the specified value, determining the intermediate value based on the deviation value and the total number of measurements, determining the standard deviation of the measurement values ​​of the stability test under the total number of measurements, and determining the statistical value based on the intermediate value and the standard deviation.

[0128] Exemplarily, the statistical value may be determined by formula (1), as follows:

[0129]

[0130] Where t represents the statistical value; μ is the specified value; n represents the total number of measurements for stability testing; It represents the corrected mean value of the stability test n times; s represents the standard deviation of the measured values ​​of the stability test n times.

[0131] Based on Example 1, the method of obtaining the critical value of the stability test may include: determining the degree of freedom of the critical value according to the total number of measurements of the stability test, and determining the critical value in the t distribution according to the preset confidence level and degree of freedom.

[0132] For example, if n is 6, then n-1 is the degree of freedom, and the degree of freedom is 5. The significance level can be taken as α=0.05, and the critical value is determined as t in the t distribution. 0.05( 5 ) .

[0133] If the statistical value t <t 0.05( 5 ) , then the stability of the liquid sample meets the requirements, and the stability conclusion of the liquid sample is stable.

[0134] Embodiment 2:

[0135] In the present disclosure, the t-test method can be selected to compare whether there is a significant difference between two mean values ​​to determine stability.

[0136] Exemplarily, determining the statistical value based on the corrected mean value may include the following steps: obtaining the uniformity mean value of the uniformity test by testing the liquid sample for uniformity, and correcting the uniformity mean value to a preset test date according to the half-life of the radionuclide to obtain the uniformity corrected mean value, and determining the statistical value based on the uniformity corrected mean value and the corrected mean value of the stability test.

[0137] The statistical value can be determined by formula (2) as follows:

[0138]

[0139] Where t represents the statistical value; n represents the total number of measurements for stability testing; represents the corrected mean value of the stability test n times; s represents the standard deviation of the stability test n times; n1 represents the total number of measurements of the uniformity test; It represents the uniformity corrected mean value of the uniformity test; s1 represents the standard deviation of the n measured values ​​of the uniformity test.

[0140] Based on Example 2, the method of obtaining the critical value of the stability test may include: determining the degrees of freedom of the critical value based on the total number of measurements of the stability test and the total number of measurements of the uniformity test, and determining the critical value in the t distribution based on pre-set confidence and degrees of freedom.

[0141] The specific method will not be repeated here.

[0142] In a possible embodiment, the liquid sample processing process of the three stability test parameters of temperature, time and sample packaging is described through the following three embodiments.

[0143] It should be noted that there may be other factors that affect the liquid sample, which can be used as stability test parameters for testing the liquid sample. Other stability test parameters will not be repeated, and the factors that may affect the liquid sample are included in the stability test parameters of the present disclosure.

[0144] Example 3: Temperature.

[0145] Figure 4 A flow chart of a sample processing process in which the stability test parameter is temperature in an embodiment of the present disclosure is shown. Figure 4 As shown, the following steps are included:

[0146] S402: Determine that the stability test parameter is temperature.

[0147] S404: placing the liquid sample to be processed in an environment of a first preset temperature for a first preset number of days, then placing it in an environment of a second preset temperature for a second preset number of days, and restoring it to room temperature to obtain a liquid sample to be tested that has undergone temperature testing.

[0148] In a possible embodiment, taking the liquid sample as a water sample as an example, the first preset temperature may be 60° C.; the first preset number of days may be 3 days; the second preset temperature may be -17° C.; and the second preset number of days may be 1 day.

[0149] The high temperature environment may be an oven, and the low temperature environment may be a refrigerator.

[0150] The time period from the time the liquid sample is sent out to the time when the proficiency test begins in the hands of the participant can be called the time period for distributing the liquid sample.

[0151] Through the above method, it is simulated whether the stability of the liquid sample will change after returning to normal temperature due to high temperature and low temperature during the period of distributing the liquid sample.

[0152] After analyzing the radioactive nuclides in the liquid sample to be tested after the temperature test, a stability conclusion is obtained to determine the stability of the liquid sample under high and low temperature conditions.

[0153] It should be noted that the first preset temperature may be a temperature value within a temperature range greater than the first temperature value. The second preset temperature may be a temperature value within a temperature range less than the second temperature value. The first preset number of days and the second preset number of days may be dynamically set according to the time period for distributing the liquid sample. The first temperature value may be the highest temperature that may be encountered during the transportation, storage and analysis of the liquid sample; the second temperature value may be the lowest temperature that may be encountered during the transportation, storage and analysis of the sample.

[0154] For example, taking the liquid sample as a water sample, three samples are randomly selected, stored in an oven at 60°C for 3 days, and frozen in a refrigerator at -17°C for 1 day to obtain the liquid samples to be tested corresponding to the temperature test.

[0155] After obtaining the liquid sample to be tested, a stability conclusion corresponding to the temperature test is obtained.

[0156] Example 4: Time.

[0157] Figure 5 A flow chart of a sample processing process in which the stability test parameter is time in an embodiment of the present disclosure is shown. Figure 5 As shown, the following steps are included:

[0158] S502: Determine the stability test parameter as time.

[0159] S504: placing each liquid sample to be processed in an environment within a preset temperature range and a preset humidity range for a target period of time to obtain a liquid sample to be tested that has undergone time storage testing.

[0160] Among them, include: starting time node and ending time node.

[0161] The starting time node is: the time node when each liquid sample to be processed is placed in an environment within a preset temperature range and a preset humidity range.

[0162] The end time node is: the time node when the liquid samples are distributed to the participants for proficiency testing and the testing results are obtained.

[0163] In a possible embodiment, taking the liquid sample as a water sample as an example, the preset humidity range is less than 60%; the preset temperature range is 10°C to 35°C.

[0164] The purpose of placing the target time period is, first of all, to exclude the influence of long storage time in the results obtained by the participants in the proficiency test. It can be understood that if the stability conclusion of the liquid sample tested for time is stable after the target time period, then the storage time has no effect on the stability of the liquid sample, and the results obtained by the participants in the proficiency test that do not meet expectations are not caused by the storage time. Secondly, the storage time can also be extended, and the time span for the storage time test can be 6 months.

[0165] For example, taking the liquid sample as a water sample, three samples are randomly selected and stored in an environment where the temperature is maintained at 10°C to 35°C and the humidity is less than 60%. After the participant returns the result, the sample is taken out to obtain the liquid sample to be tested corresponding to the storage time test.

[0166] It should be noted that in the present disclosure, different stability test parameter testing processes may be performed separately for different rounds. For example, only temperature testing may be performed for the first round, and only storage time testing may be performed for the second round.

[0167] It is also possible to carry out multiple inspection processes such as storage time inspection and temperature inspection at the same time for the same round. If multiple inspections are carried out at the same time, it is necessary to directly extract liquid samples for storage time inspection and temperature inspection from the same batch of liquid samples. It is necessary to extract the same batch of liquid samples.

[0168] For example, taking the example of performing multiple tests simultaneously in the same round as an example, the specific method may include:

[0169] Taking the existence of k liquid samples as an example, you can choose to use k1 for uniformity test, k2 for humidity test, k3 for distribution to participants for proficiency testing, and k4 for storage time test. If other stability test parameters need to be tested, you can continue to randomly select from the k liquid samples.

[0170] It should be noted that when the numbers of the liquid samples to be processed are randomly generated, the numbers of the liquid samples to be processed drawn will not be repeated with the numbers of the liquid samples to be processed drawn previously.

[0171] Here, we only take 4 samples from k liquid samples as an example, and the specific limit of quantity can be: k2 = k4 = 3. k2 is 3 randomly selected from k-k1, and k4 is 3 randomly selected from k-k1-k2-k3.

[0172] After obtaining the liquid sample to be tested, a stability conclusion corresponding to the storage time test is obtained.

[0173] Example 5: Sample packaging.

[0174] Figure 6 A flow chart showing a sample processing process in which a stability test parameter is sample packaging in an embodiment of the present disclosure is shown. Figure 6 As shown, the following steps are included:

[0175] S602: Determine the stability test parameter as sample packaging.

[0176] S604: Setting the same sealed package for each liquid sample to be processed to obtain a packaged liquid sample, wherein the inspection environment in the sealed package is a normal environment.

[0177] The normal environment can be understood as a situation where the temperature and humidity are both at normal temperature and normal humidity.

[0178] S606: Each liquid sample to be processed is mailed to a preset distance via a delivery order to obtain a liquid sample to be tested.

[0179] In a possible embodiment, the sealed package may be a disposable plastic-sealed plastic bottle.

[0180] The delivery order is mailed over a preset distance, which can be greater than 1,000 kilometers, to ensure that enough time is left for the transportation process. After the preset distance is mailed, the liquid sample to be tested is obtained, and then the corresponding analysis and measurement are performed on the liquid sample to be tested, and the corresponding stability conclusion of the sample packaging inspection is obtained.

[0181] Based on the same inventive concept, the present disclosure also provides a capability verification liquid sample stability testing device, such as the following embodiment. Since the principle of solving the problem in the device embodiment is similar to that in the above method embodiment, the implementation of the device embodiment can refer to the implementation of the above method embodiment, and the repeated parts will not be repeated.

[0182] Figure 7 FIG. 1 is a schematic diagram showing a structure of a capability verification liquid sample stability testing device according to an embodiment of the present disclosure. Figure 7 As shown, the capability verification liquid sample stability testing device 70 comprises:

[0183] The acquisition unit 701 is used to acquire a preset number of liquid samples to be processed; the processing unit 702 is used to determine the stability test parameters of the liquid samples to be processed, and place the liquid samples to be processed in a test environment corresponding to the stability test parameters for processing to obtain the liquid samples to be tested; the stability test parameters at least include: temperature; the analysis and measurement unit 703 is used to analyze the radioactive nuclides in the preset number of liquid samples to be tested according to the standard analysis method, and obtain the measured average value of the radioactive nuclides in the preset number of liquid samples to be tested; the correction unit 704 is used to correct the measured average value to the preset test date according to the half-life of the radioactive nuclides, and obtain the corrected average value; the output unit 705 is used to obtain the stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

[0184] Those skilled in the art will appreciate that various aspects of the present disclosure may be implemented as systems, methods or program products. Therefore, various aspects of the present disclosure may be specifically implemented in the following forms, namely: complete hardware implementation, complete software implementation (including firmware, microcode, etc.), or a combination of hardware and software, which may be collectively referred to herein as "circuits", "modules" or "systems".

[0185] Refer to the following Figure 8 The electronic device 800 according to this embodiment of the present disclosure is described. Figure 8 The electronic device 800 shown is merely an example and should not bring any limitation to the functions and scope of use of the embodiments of the present disclosure.

[0186] like Figure 8 As shown, the electronic device 800 is in the form of a general computing device. The components of the electronic device 800 may include but are not limited to: at least one processing unit 810, at least one storage unit 820, and a bus 830 connecting different system components (including the storage unit 820 and the processing unit 810).

[0187] The storage unit stores program codes, which can be executed by the processing unit 810, so that the processing unit 810 performs the steps of various exemplary embodiments of the present disclosure described in the above “Exemplary Method” section of this specification. For example, the processing unit 810 can perform any step of the above method embodiments.

[0188] The storage unit 820 may include a readable medium in the form of a volatile storage unit, such as a random access memory unit (RAM) 8201 and / or a cache memory unit 8202 , and may further include a read-only memory unit (ROM) 8203 .

[0189] The storage unit 820 may also include a program / utility 8204 having a set (at least one) of program modules 8205, such program modules 8205 including but not limited to: an operating system, one or more application programs, other program modules, and program data, each of which or some combination may include an implementation of a network environment.

[0190] Bus 830 may represent one or more of several types of bus structures, including a memory unit bus or memory unit controller, a peripheral bus, an accelerated graphics port, a processing unit, or a local bus using any of a variety of bus architectures.

[0191] The electronic device 800 may also communicate with one or more external devices 840 (e.g., keyboards, pointing devices, Bluetooth devices, etc.), may also communicate with one or more devices that enable a user to interact with the electronic device 800, and / or communicate with any device that enables the electronic device 800 to communicate with one or more other computing devices (e.g., routers, modems, etc.). Such communication may be performed via an input / output (I / O) interface 850. Furthermore, the electronic device 800 may also communicate with one or more networks (e.g., local area networks (LANs), wide area networks (WANs), and / or public networks, such as the Internet) via a network adapter 860. As shown, the network adapter 860 communicates with other modules of the electronic device 800 via a bus 830. It should be understood that, although not shown in the figure, other hardware and / or software modules may be used in conjunction with the electronic device 800, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems, etc.

[0192] Through the description of the above implementation, it is easy for those skilled in the art to understand that the example implementation described here can be implemented by software, or by software combined with necessary hardware. Therefore, the technical solution according to the implementation of the present disclosure can be embodied in the form of a software product, which can be stored in a non-volatile storage medium (which can be a CD-ROM, a USB flash drive, a mobile hard disk, etc.) or on a network, including several instructions to enable a computing device (which can be a personal computer, a server, a terminal device, or a network device, etc.) to execute the method according to the implementation of the present disclosure.

[0193] In particular, according to an embodiment of the present disclosure, the process described above with reference to the flowchart can be implemented as a computer program product or a computer program, which includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The processor of the computer device reads the computer instructions from the computer-readable storage medium, and the processor executes the computer instructions, so that the computer device executes the method in the above embodiment.

[0194] In an exemplary embodiment of the present disclosure, a computer-readable storage medium is also provided, which may be a readable signal medium or a readable storage medium. A program product capable of implementing the above method of the present disclosure is stored thereon. In some possible implementations, various aspects of the present disclosure may also be implemented in the form of a program product, which includes a program code, and when the program product is run on a terminal device, the program code is used to enable the terminal device to execute the steps according to various exemplary implementations of the present disclosure described in the above “Exemplary Method” section of this specification.

[0195] More specific examples of computer-readable storage media in the present disclosure may include, but are not limited to, an electrical connection having one or more conductors, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0196] In the present disclosure, a computer readable storage medium may include a data signal propagated in baseband or as part of a carrier wave, wherein a readable program code is carried. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. A readable signal medium may also be any readable medium other than a readable storage medium, which may send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device.

[0197] Alternatively, the program code contained on the computer-readable storage medium may be transmitted using any appropriate medium, including but not limited to wireless, wired, optical cable, RF, etc., or any suitable combination of the foregoing.

[0198] In a specific implementation, the program code for performing the operations of the present disclosure may be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java, C++, etc., and conventional procedural programming languages ​​such as "C" or similar programming languages. The program code may be executed entirely on the user computing device, partially on the user device, as a separate software package, partially on the user computing device and partially on a remote computing device, or entirely on a remote computing device or server. In the case of a remote computing device, the remote computing device may be connected to the user computing device through any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computing device (e.g., using an Internet service provider to connect through the Internet).

[0199] It should be noted that, although several modules or units of the device for action execution are mentioned in the above detailed description, this division is not mandatory. In fact, according to the embodiments of the present disclosure, the features and functions of two or more modules or units described above can be embodied in one module or unit. On the contrary, the features and functions of one module or unit described above can be further divided into multiple modules or units to be embodied.

[0200] In addition, although the steps of the method in the present disclosure are described in a specific order in the drawings, this does not require or imply that the steps must be performed in this specific order, or that all the steps shown must be performed to achieve the desired results. Additionally or alternatively, some steps may be omitted, multiple steps may be combined into one step, and / or one step may be decomposed into multiple steps, etc.

[0201] Through the description of the above implementation, it is easy for those skilled in the art to understand that the example implementation described here can be implemented by software, or by software combined with necessary hardware. Therefore, the technical solution according to the implementation of the present disclosure can be embodied in the form of a software product, which can be stored in a non-volatile storage medium (which can be a CD-ROM, a USB flash drive, a mobile hard disk, etc.) or on a network, including several instructions to enable a computing device (which can be a personal computer, a server, a mobile terminal, or a network device, etc.) to execute the method according to the implementation of the present disclosure.

[0202] Those skilled in the art will readily appreciate other embodiments of the present disclosure after considering the specification and practicing the invention disclosed herein. The present disclosure is intended to cover any variations, uses or adaptations of the present disclosure, which follow the general principles of the present disclosure and include common knowledge or customary techniques in the art that are not disclosed in the present disclosure. The description and examples are intended to be exemplary only, and the true scope and spirit of the present disclosure are indicated by the appended claims.

[0203] The embodiments of the present invention are described in detail above with reference to the accompanying drawings, but the present invention is not limited thereto, and various changes can be made within the knowledge scope of technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A method for testing the stability of liquid samples for capability testing, characterized in that: The method comprises the following specific steps: S202, randomly extracting a preset number of liquid samples to be processed from the liquid samples; S204, determining stability test parameters of the liquid sample to be processed, placing the liquid sample to be processed in a test environment corresponding to the stability test parameters for processing, and obtaining the liquid sample to be tested; The stability test parameters include at least: temperature; S206, analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to a standard analysis method to obtain a measured average value of the radioactive nuclides in the preset number of the liquid samples to be tested; S208, correcting the measured average value to a preset inspection date according to the half-life of the radionuclide to obtain a corrected average value; S210. Obtaining a stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

2. The method for testing the stability of a liquid sample according to claim 1, wherein: In step S204, the stability test parameter is determined to be temperature; The liquid sample to be processed is placed in an environment with a first preset temperature for a first preset number of days, then placed in an environment with a second preset temperature for a second preset number of days, and restored to normal temperature to obtain a liquid sample to be tested that has undergone temperature testing.

3. The method for testing the stability of a liquid sample according to claim 1, characterized in that: The stability test parameters in step S204 also include: time; Determining the stability test parameter as time; Placing each of the liquid samples to be processed in an environment within a preset temperature range and a preset humidity range for a target period of time to obtain the liquid samples to be tested after time storage testing; Wherein, the target time period includes: a start time node and an end time node; The starting time node is: the time node when each of the liquid samples to be processed is placed in an environment within a preset temperature range and a preset humidity range; The end time node is: the time node when the liquid sample is distributed to the participant for proficiency testing and the testing result is obtained.

4. The method for testing the stability of a liquid sample according to claim 1, wherein: The stability test parameters in step S204 also include: sample packaging; Determining the stability test parameter as sample packaging; The same sealed package is provided for each of the liquid samples to be processed to obtain a packaged liquid sample; the inspection environment in the sealed package is a conventional environment; Each of the liquid samples to be processed is mailed to a preset distance via a delivery order to obtain a liquid sample to be tested.

5. The method for testing the stability of a liquid sample according to claim 1, characterized in that: The stability test parameters also include at least: time and sample packaging; The method further comprises: Obtaining a first stability conclusion in which the stability test parameter is temperature, a second stability conclusion in which the stability test parameter is time, and a third stability conclusion in which the stability test parameter is sample packaging; A stability conclusion of the liquid sample is determined based on the first stability conclusion, the second stability conclusion and the third stability conclusion.

6. The method for testing the stability of a liquid sample for capability testing according to claim 1, characterized in that: Step S206 also includes the following steps: In the process of analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to the standard analysis method, the radioactive nuclides in each of the liquid samples to be tested are detected in parallel to obtain the measured value of the radioactive nuclides in each of the liquid samples to be tested; For each of the liquid samples to be tested, the radioactive nuclide is repeatedly measured for a preset number of times to obtain a measurement value of a total number of measurements; the total number of measurements is the product of the preset number of times and the preset quantity; A measurement average value is determined based on the measurement values ​​of the total number of measurements.

7. The method for testing the stability of a liquid sample for capability testing according to claim 1, characterized in that: Step S210 also includes the following steps: Determining a statistical value according to the modified mean value; Get the critical value of stability test; If the statistical value is less than the critical value, the stability conclusion of the liquid sample under the stability test parameter is determined to be stable.

8. A capability verification liquid sample stability testing device, which tests the stability of the capability verification liquid sample according to the steps of the method according to any one of claims 1 to 7, characterized in that: include: An acquisition unit, used for randomly extracting a preset number of liquid samples to be processed from the liquid samples; A processing unit, used to determine the stability test parameters of the liquid sample to be processed, and place the liquid sample to be processed in a test environment corresponding to the stability test parameters to obtain the liquid sample to be tested; The stability test parameters include at least: temperature; An analysis and measurement unit, used for analyzing the radioactive nuclides in a preset number of the liquid samples to be tested according to a standard analysis method, and obtaining a measurement average value of the radioactive nuclides in the preset number of the liquid samples to be tested; A correction unit, used for correcting the measured average value to a preset inspection date according to the half-life of the radionuclide to obtain a corrected average value; The output unit is used to obtain the stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

9. An electronic device, characterized in that: include: processor; as well as A memory, configured to store executable instructions of the processor; The processor is configured to perform the steps of the method of any one of claims 1 to 7 by executing the executable instructions.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 7 are implemented.

11. A computer program product comprising: A computer program or instruction, characterized in that when the computer program or instruction is executed by a processor, the steps of the method described in any one of claims 1 to 7 are implemented.

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