Method for testing the stability of a proficiency testing liquid sample and related apparatus

Abstract

The application provides a capability verification liquid sample stability test method and related equipment, and relates to the technical field of radionuclide analysis.The method comprises the following steps: randomly drawing a preset number of to-be-processed liquid samples from a liquid sample, determining a stability test parameter, placing the to-be-processed liquid samples into corresponding test environments for processing, obtaining to-be-tested liquid samples, and the stability test parameter at least comprising a temperature.An analysis is performed according to a standard analysis method to obtain a measurement average value of a radionuclide, the measurement average value is corrected to a preset test date according to a half-life of the radionuclide to obtain a corrected average value, and a stability conclusion of the liquid sample under the stability test parameter is obtained according to the corrected average value.The method can test factors affecting the stability of the capability verification liquid sample, avoid the influence of these factors during the analysis of the activity concentration of the radionuclide, and improve the reliability of the analysis result of the activity concentration of the radionuclide.

Description

Technical Field

[0001] This invention relates to the field of radionuclide analysis technology, and in particular to a method and related equipment for proficiency testing of the stability of liquid samples. Background Technology

[0002] Radioactivity, as an intrinsic property of the atomic nucleus, does not change with external conditions. Therefore, the concentration of radioactive nuclides in a liquid sample remains constant.

[0003] However, radionuclides exist in a medium, such as a proficiency testing liquid sample. Changes in the mass of the proficiency testing liquid sample may cause changes in the concentration of radionuclides. During analysis, testing, distribution, and storage, various factors may affect the proficiency testing liquid sample, leading to insufficient stability and thus affecting the concentration of radionuclides, thereby impacting the reliability of the radionuclide activity concentration analysis results.

[0004] It should be noted that the information disclosed in the background section above is only used to enhance the understanding of the background of this disclosure, and therefore may include information that does not constitute prior art known to those skilled in the art. Summary of the Invention

[0005] This disclosure provides a method and related equipment for testing the stability of liquid samples, which at least to some extent tests the factors that affect the stability of proficiency testing liquid samples, and solves the problem of reduced reliability of radionuclide activity concentration analysis results due to the stability of proficiency testing liquid samples.

[0006] Other features and advantages of this disclosure will become apparent from the following detailed description, or may be learned in part from practice of this disclosure.

[0007] The technical solution of the present invention,

[0008] In a first aspect, the present invention provides a method for testing the stability of liquid samples in proficiency testing, the method comprising the following specific steps:

[0009] S202. Randomly select a preset number of liquid samples to be processed from the liquid samples;

[0010] S204. Determine the stability test parameters of the liquid sample to be processed, and place the liquid sample to be processed in the test environment corresponding to the stability test parameters to obtain the liquid sample to be tested; the stability test parameters include at least: temperature;

[0011] S206. Analyze the radionuclides in the preset number of liquid samples to be tested according to the standard analytical method, and obtain the average measured value of the radionuclides in the preset number of liquid samples to be tested.

[0012] S208. Based on the half-life of the radionuclide, the average measurement value is corrected to a preset inspection date to obtain a corrected average value;

[0013] S210. Based on the corrected average value, the stability conclusion of the liquid sample under the stability test parameters is obtained.

[0014] Preferably, in step S204, the stability test parameter is determined to be temperature;

[0015] The liquid sample to be processed is placed in an environment at a first preset temperature for a first preset number of days, then in an environment at a second preset temperature for a second preset number of days, and then returned to room temperature to obtain a liquid sample to be tested that has passed the temperature test.

[0016] Preferably, the stability test parameter in step S204 further includes: time;

[0017] The stability test parameter is determined to be time;

[0018] Each of the liquid samples to be processed is placed in an environment with a preset temperature range and a preset humidity range for a target time period to obtain a liquid sample to be tested that has passed the time storage test.

[0019] The target time period includes a start time node and an end time node;

[0020] The starting time point is the time point at which each of the liquid samples to be processed is placed in an environment with a preset temperature range and a preset humidity range.

[0021] The end time point is the time when the liquid sample is distributed to the participants for proficiency testing and the testing results are obtained.

[0022] Preferably, the stability test parameters in step S204 further include: sample packaging;

[0023] The stability test parameters were determined to be the sample packaging.

[0024] Each of the liquid samples to be processed is placed in the same sealed packaging to obtain the packaged liquid samples; the testing environment in the sealed packaging is a normal environment;

[0025] Each of the liquid samples to be processed is mailed at a preset distance via a delivery order to obtain the liquid samples to be tested.

[0026] Preferably, the stability testing parameters further include at least: time and sample packaging;

[0027] The method further includes:

[0028] The stability test parameters were determined as follows: first stability conclusion with temperature as the stability test parameter, second stability conclusion with time as the stability test parameter, and third stability conclusion with sample packaging as the stability test parameter.

[0029] Based on the first stability conclusion, the second stability conclusion, and the third stability conclusion, the stability conclusion of the liquid sample is determined.

[0030] Preferably, step S206 further includes the following steps:

[0031] During the analysis of radionuclides in a preset number of liquid samples to be tested according to standard analytical methods, the radionuclides in each liquid sample to be tested are detected in parallel to obtain the measured value of the radionuclides in each liquid sample to be tested.

[0032] For each of the liquid samples to be tested, the radionuclide is measured repeatedly a preset number of times to obtain the total number of measurements; the total number of measurements is the product of the preset number of measurements and the preset quantity.

[0033] The average measurement value is determined based on the total number of measurements.

[0034] Preferably, step S210 further includes the following steps:

[0035] The statistical value is determined based on the corrected average value;

[0036] Obtain the critical value for stability testing;

[0037] If the statistical value is less than the critical value, then the stability conclusion of the liquid sample under the stability test parameters is determined to be stable.

[0038] Secondly, the present invention provides a proficiency testing liquid sample stability testing apparatus, which tests the stability of proficiency testing liquid samples according to the steps of the above method, including:

[0039] The acquisition unit is used to randomly extract a preset number of liquid samples to be processed from the liquid sample;

[0040] A processing unit is used to determine the stability test parameters of the liquid sample to be processed, place the liquid sample to be processed in a test environment corresponding to the stability test parameters, and obtain the liquid sample to be tested; the stability test parameters include at least: temperature;

[0041] The analysis and measurement unit is used to analyze the radionuclides in a preset number of liquid samples to be tested according to standard analysis methods, and to obtain the average measurement value of the radionuclides in the preset number of liquid samples to be tested.

[0042] The correction unit is used to correct the average measurement value to a preset inspection date based on the half-life of the radionuclide, thereby obtaining a corrected average value.

[0043] The output unit is used to obtain the stability conclusion of the liquid sample under the stability test parameters based on the corrected average value.

[0044] Thirdly, the present invention provides an electronic device, comprising:

[0045] Processor; and

[0046] Memory for storing the executable instructions of the processor;

[0047] The processor is configured to perform the steps of the above method by executing the executable instructions.

[0048] Fourthly, the present invention provides a computer-readable storage medium having a computer program stored thereon, wherein the computer program, when executed by a processor, implements the steps of the above-described method.

[0049] Fifthly, the present invention provides a computer program product, comprising: a computer program or instructions, wherein the computer program or instructions, when executed by a processor, implement the steps of the above-described method.

[0050] Compared with the prior art, the present invention has the following beneficial technical effects:

[0051] This invention provides a complete and reproducible method for testing the stability of proficiency testing liquid samples for the detection of radionuclides. The method of this invention can test the factors that affect the stability of proficiency testing liquid samples, avoid the influence of these factors during the analysis of radionuclide activity concentration, and improve the reliability of radionuclide activity concentration analysis results. Attached Figure Description

[0052] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with this disclosure and, together with the description, serve to explain the principles of this disclosure. It is obvious that the drawings described below are merely some embodiments of this disclosure, and those skilled in the art can obtain other drawings based on these drawings without any inventive effort.

[0053] Figure 1This diagram illustrates a proficiency testing system for liquid sample stability according to an embodiment of the present disclosure.

[0054] Figure 2 This diagram shows a flowchart of a proficiency testing method for verifying the stability of liquid samples according to an embodiment of the present disclosure.

[0055] Figure 3 A schematic diagram illustrating an embodiment of this disclosure for obtaining a stability conclusion is shown;

[0056] Figure 4 A flowchart illustrating a sample processing procedure in which temperature is used as a stability testing parameter in an embodiment of this disclosure is shown.

[0057] Figure 5 A flowchart illustrating a sample processing procedure in which time is used as the stability testing parameter in an embodiment of this disclosure is shown.

[0058] Figure 6 This document illustrates a flowchart of a sample processing procedure in which the stability testing parameter is the sample packaging, as shown in an embodiment of the present disclosure.

[0059] Figure 7 This diagram illustrates a proficiency testing apparatus for liquid sample stability in an embodiment of the present disclosure.

[0060] Figure 8 A schematic diagram of an electronic device according to an embodiment of the present disclosure is shown. Detailed Implementation

[0061] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the examples set forth herein; rather, they are provided so that this disclosure will be more comprehensive and complete, and will fully convey the concept of the exemplary embodiments to those skilled in the art. The described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

[0062] Furthermore, the accompanying drawings are merely illustrative of this disclosure and are not necessarily drawn to scale. The same reference numerals in the drawings denote the same or similar parts, and therefore repeated descriptions of them will be omitted. Some block diagrams shown in the drawings are functional entities and do not necessarily correspond to physically or logically independent entities. These functional entities may be implemented in software, in one or more hardware modules or integrated circuits, or in different network and / or processor devices and / or microcontroller devices.

[0063] Figure 1 A schematic diagram is shown of a proficiency testing method for liquid sample stability that can be applied to embodiments of this disclosure.

[0064] like Figure 1 As shown, the proficiency testing system 100 for liquid sample stability testing may include a terminal device 101, a network 102, and a server 103.

[0065] Network 102 is a medium used to provide a communication link between terminal device 101 and server 103, and can be a wired network or a wireless network.

[0066] Optionally, the aforementioned wireless or wired networks use standard communication technologies and / or protocols. The network is typically the Internet, but can also be any network, including but not limited to Local Area Networks (LANs), Metropolitan Area Networks (MANs), Wide Area Networks (WANs), mobile, wired or wireless networks, private networks, or any combination of virtual private networks. In some embodiments, technologies and / or formats including Hyper Text Markup Language (HTML), Extensible Markup Language (XML), etc., are used to represent data exchanged over the network. Furthermore, conventional encryption technologies such as Secure Socket Layer (SSL), Transport Layer Security (TLS), Virtual Private Networks (VPNs), and Internet Protocol Security (IPsec) can be used to encrypt all or some links. In other embodiments, custom and / or dedicated data communication technologies can be used to replace or supplement the aforementioned data communication technologies.

[0067] Terminal device 101 can be various electronic devices, including but not limited to smartphones, tablets, laptops, desktop computers, wearable devices, augmented reality devices, virtual reality devices, etc.

[0068] Optionally, the client of the application installed on different terminal devices 101 may be the same, or the client of the same type of application based on different operating systems. Depending on the terminal platform, the specific form of the application client may also be different; for example, the application client may be a mobile client, a PC client, etc.

[0069] Server 103 can be a server that provides various services, such as a backend management server that supports the device operated by the user using terminal device 101. The backend management server can analyze and process received requests and other data, and feed the processing results back to the terminal device.

[0070] Optionally, the server can be a standalone physical server, a server cluster or distributed system composed of multiple physical servers, or a cloud server providing basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communication, middleware services, domain name services, security services, CDN (Content Delivery Network), and big data and artificial intelligence platforms. The terminal can be a smartphone, tablet, laptop, desktop computer, smart speaker, smartwatch, etc., but is not limited to these. The terminal and server can be directly or indirectly connected via wired or wireless communication, and this disclosure does not impose any restrictions.

[0071] Those skilled in the art will know that Figure 1 The number of terminal devices, networks, and servers shown is merely illustrative; any number of terminal devices, networks, and servers can be included depending on actual needs. This disclosure does not limit the scope of the embodiments.

[0072] The following detailed description of this exemplary implementation method is provided in conjunction with the accompanying drawings and embodiments.

[0073] First, this disclosure provides a method for testing the stability of liquid samples for proficiency testing. This method can be executed by any electronic device with computing capabilities. In the following process, an electronic device is used as an example as the terminal device.

[0074] Figure 2 A flowchart illustrating a proficiency testing method for liquid sample stability is shown in an embodiment of this disclosure, as follows: Figure 2 As shown in the embodiments of this disclosure, the method for testing the stability of liquid samples for proficiency testing includes the following steps:

[0075] S202: Randomly select a preset number of liquid samples to be processed from the liquid samples.

[0076] In one possible embodiment, the preset number of liquid samples to be processed can be randomly drawn from the original liquid samples.

[0077] In one possible embodiment, the preset quantity can include multiple types. For ease of verification, the preset quantity can be selected as 3.

[0078] In one possible embodiment, the random sampling process may include: taking the existence of k liquid samples as an example, the k liquid samples are sequentially numbered, and three random numbers can be randomly generated using an Excel random number generator program, which will be used as the numbers of the randomly sampled liquid samples.

[0079] In one possible embodiment, the liquid sample may include various types, such as water samples, oil samples, and mixtures of oil and water. The liquid sample is a medium containing radioactive nuclides. This disclosure does not limit the specific type of liquid sample; the following embodiments use water samples as an example.

[0080] This disclosure does not limit the radionuclide and can be any kind of radionuclide. In this disclosure, strontium-90 is used as an example.

[0081] S204: Determine the stability test parameters for the liquid sample to be processed, place the liquid sample to be processed in the test environment corresponding to the stability test parameters, and obtain the liquid sample to be tested. The stability test parameters include at least: temperature.

[0082] In one possible embodiment, stability testing of liquid samples may be affected by various factors. Depending on the actual situation, staff can input corresponding stability testing parameters during the testing process. The terminal device can determine the stability testing parameters of the liquid sample to be processed and perform corresponding processing based on the stability testing parameters to obtain the liquid sample to be tested.

[0083] The content of radionuclides remains unchanged, but various factors can affect the liquid sample, causing changes in the liquid sample and ultimately leading to changes in the concentration of radionuclides.

[0084] For example, during transportation, both high and low temperatures may affect liquid samples, causing them to evaporate or other problems to occur.

[0085] For example, in actual proficiency testing, prolonged storage of liquid samples can affect their stability.

[0086] For example, the packaging used for storing liquid samples may also affect the liquid samples during each proficiency test.

[0087] Different types of liquid samples may require different stability testing parameters.

[0088] For example, for water samples, stability testing parameters may include temperature, time, and sample packaging.

[0089] For petroleum samples, stability testing parameters may also include factors that may affect the stability of the petroleum during transportation.

[0090] In one possible embodiment, the stability test parameters determined by the terminal device can be input by the operator through an input interface displayed by the terminal device after determining the type of liquid sample. Alternatively, they can be pre-set according to different types of liquid samples.

[0091] In one possible embodiment, the specific method for determining the stability testing parameters of the liquid sample to be processed may further include: according to the target type of the liquid sample, traversing the historical stability testing records of liquid samples of the target type from the database; according to the historical stability testing records, obtaining a dataset of proficiency testing analysis results of radionuclides when the liquid sample of the target type is used as a proficiency testing medium for radionuclides; obtaining the abnormal analysis results of proficiency testing of radionuclides from the dataset; obtaining the first liquid sample of the target type in the abnormal analysis process corresponding to the abnormal analysis results, and the second liquid sample of the target type in the normal analysis process corresponding to the normal analysis results; comparing the first liquid sample and the second liquid sample to obtain the influencing factors of the stability of the first liquid sample, and using the influencing factors as stability testing parameters.

[0092] S206: Analyze the radionuclides in a predetermined number of liquid samples to be tested according to the standard analytical method, and obtain the average measured value of the radionuclides in the predetermined number of liquid samples to be tested.

[0093] In one possible embodiment, the standard analytical method may include a standard analytical method specified for analyzing radionuclides, such as the HJ815-2016 standard analytical method, but this disclosure is not limited thereto.

[0094] In one possible embodiment, the corresponding standard analytical methods may differ for different radionuclides.

[0095] In one possible embodiment, the method for obtaining the average measurement value of a radionuclide may include: during the analysis of radionuclides in a preset number of liquid samples to be tested according to a standard analytical method, performing parallel detection of radionuclides in each liquid sample to be tested to obtain the measured value of radionuclides in each liquid sample to be tested; for each liquid sample to be tested, repeating the measurement of radionuclides a preset number of times to obtain the measured value of the total number of measurements; the total number of measurements is the product of the preset number of measurements and the preset quantity; and determining the average measurement value based on the measured value of the total number of measurements.

[0096] There are many other ways to analyze and measure radionuclides. This disclosure uses the α / β counter measurement method as an example, but it is not limited to this.

[0097] The standard analytical methods all include specific analytical procedures for radionuclides. The specific analytical procedures in the standard analytical methods will not be described in detail in this disclosure.

[0098] Using the standard analytical method described above, the measured value of each liquid sample to be tested is obtained. For each liquid sample to be tested, the measurement can be repeated a preset number of times to obtain the total number of measurements and determine the average value.

[0099] The total number of measurements, n, is the product of the preset number of measurements and the preset quantity. In this disclosure, the preset number of measurements can be set to 2, then n = 6.

[0100] The measured value of the radionuclide is the activity concentration of strontium-90.

[0101] S208: Based on the half-life of the radionuclide, the average measurement value is corrected to the preset inspection date to obtain the corrected average value.

[0102] In one possible embodiment, the radionuclide has a half-life. After obtaining the average measurement value, it is necessary to correct the average measurement value according to the half-life, and correct it to a preset inspection date to obtain the corrected average value.

[0103] For example, if the current date for obtaining the average measurement value is September 2, 2024, the preset verification date can also be understood as a specified date, such as September 20, 2024. In this case, the average measurement value obtained is not on the specified date. It is corrected according to the half-life of the radionuclide to obtain the corrected average value of the radionuclide on September 20, 2024.

[0104] This disclosure does not specify the particular method of modification.

[0105] S210: Based on the corrected average value, obtain the stability conclusion of the liquid sample under the stability test parameters.

[0106] By using the above method, the stability conclusions of liquid samples under different stability testing parameters can be obtained. When liquid samples are distributed to participants for radionuclide analysis, it is ensured that the stability of liquid samples will not be affected by certain stability testing parameters, thus preventing insufficient reliability of radionuclide analysis results. The method in this disclosure can test the stability of proficiency testing liquid samples, thereby improving the reliability of radionuclide proficiency testing analysis results, as well as improving the accuracy and credibility of the results.

[0107] In one possible embodiment, when performing stability testing on liquid samples, the corresponding stability testing parameters can be flexibly selected.

[0108] For example, if the stability test parameter only includes temperature, then only temperature can be selected as the stability test parameter. After performing the temperature test, if the stability conclusion of the liquid sample is stable, then it means that the liquid sample is stable.

[0109] For example, if the stability test parameters include temperature and time, for instance, if the liquid sample may evaporate due to long storage time, then the stability test parameters can be selected as temperature and time. After performing temperature and time tests, if the stability conclusion of the liquid sample is stable, then it means that the liquid sample is stable.

[0110] For example, if the stability test parameters include temperature, time, packaging, and other parameters, all of them can be tested, and the liquid sample is considered stable only if the stability conclusion for all the stability test parameters is obtained.

[0111] In this disclosure, taking stability testing parameters including temperature, time, and sample packaging as an example, the method for determining whether a liquid sample is stable may include: obtaining a first stability conclusion with temperature as the stability testing parameter, a second stability conclusion with time as the stability testing parameter, and a third stability conclusion with sample packaging as the stability testing parameter; and determining the stability conclusion of the liquid sample based on the first stability conclusion, the second stability conclusion, and the third stability conclusion.

[0112] For example, if the first stability conclusion, the second stability conclusion, and the third stability conclusion are all stable, then the stability conclusion of the liquid sample is stable.

[0113] For example, if the first and second stability conclusions are stable, and the third stability conclusion is unstable, then the stability conclusion of the liquid sample is unstable. It can be concluded that the instability is caused by the sample packaging, and therefore the sample packaging should be improved. For instance, if the sample packaging is a plastic bag and is damaged during transportation, causing leakage or seepage and resulting in a change in the sample's quality, then improving the packaging could involve replacing it with a more robust one to ensure the stability of the liquid sample.

[0114] In one possible implementation, after distributing liquid samples to participants for one round of proficiency testing, the remaining liquid samples are retained as reserve samples. When the retained samples are needed for a second round of proficiency testing and are redistributed to participants, the stability test should be performed on the retained samples again before redistribution. The samples can only be redistributed after the stability test is passed.

[0115] In a proficiency testing process for a single round, when conducting stability testing on liquid samples, a stability testing process with temperature and sample packaging parameters needs to be completed before distributing the liquid samples to the participants. For a stability testing process with time as the stability testing parameter, the liquid sample to be tested needs to be obtained.

[0116] In one possible embodiment, Figure 3 A flowchart illustrating one embodiment of the present disclosure for obtaining a stability conclusion is shown, such as... Figure 3 As shown, it includes the following steps:

[0117] S302: Determine the statistical value based on the corrected average.

[0118] S304: Obtain the critical value for stability testing.

[0119] S306: Determine if the statistical value is less than the critical value. If yes, execute S308; otherwise, execute S310.

[0120] S308: Determine that the stability of the liquid sample under the stability test parameters is stable.

[0121] S310: The conclusion that the stability of the liquid sample under the stability test parameters is unstable is determined.

[0122] In one possible embodiment, the stability of a sample containing a radionuclide can be determined based on the average measured value of the radionuclide, and may include various methods such as the t-test and the xy≤0.3σ criterion. The t-test can take many forms, such as comparing a corrected average with a standard / reference / specified value, or comparing two corrected averages to determine if there is a significant difference.

[0123] The specific method used can be illustrated by the following examples:

[0124] Example 1:

[0125] In this disclosure, the t-test method can be selected to compare whether there is a significant difference between a mean and a specified value in order to determine stability.

[0126] For example, determining a statistical value based on a corrected average may include the following steps: obtaining a specified value of the activity concentration of a radionuclide on a preset test date, and determining a statistical value based on the corrected average of the stability test and the specified value.

[0127] For example, determining the statistic may include: determining the deviation value based on the corrected mean of the stability test and a specified value; determining the median value based on the deviation value and the total number of measurements; determining the standard deviation of the stability test over the total number of measurements; and determining the statistic based on the median value and the standard deviation.

[0128] For example, the statistical value can be determined by formula (1), as shown below:

[0129]

[0130] Where t represents the statistical value; μ is a specified value; and n represents the total number of measurements for the stability test. represents the corrected mean of the stability tests conducted n times; s represents the standard deviation of the measurements conducted n times in the stability tests.

[0131] Based on Example 1, the method for obtaining the critical value of the stability test may include: determining the degree of freedom of the critical value based on the total number of measurements of the stability test, and determining the critical value in the t-distribution based on the pre-set confidence level and degree of freedom.

[0132] For example, taking n=6 as an example, then n-1 gives the degrees of freedom, and the degrees of freedom is 5. We can take a significance level, i.e., a confidence level of α=0.05, and then determine the critical value t in the t-distribution. 0.05( 5 ) .

[0133] If the statistical value t <t 0.05( 5 ) If the stability of the liquid sample meets the requirements, the conclusion that the liquid sample is stable can be drawn.

[0134] Example 2:

[0135] In this disclosure, the t-test method can be selected to compare whether there is a significant difference between two means in order to determine stability.

[0136] For example, determining the statistical value based on the corrected average value may include the following steps: obtaining the homogeneity average value of the homogeneity test from the homogeneity test of the liquid sample, correcting the homogeneity average value to a preset test date according to the half-life of the radionuclide, to obtain the homogeneity corrected average value, and determining the statistical value based on the homogeneity corrected average value and the stability test corrected average value.

[0137] The statistical value can be determined using formula (2), as shown below:

[0138]

[0139] Where t represents the statistical value; n represents the total number of measurements for the stability test; represents the corrected mean of n stability tests; s represents the standard deviation of n stability tests; n1 represents the total number of measurements for the uniformity test. s1 represents the homogeneity-corrected mean of the homogeneity test; s2 represents the standard deviation of n measurements in the homogeneity test.

[0140] Based on Example 2, the method for obtaining the critical value of the stability test may include: determining the degree of freedom of the critical value based on the total number of measurements of the stability test and the total number of measurements of the uniformity test, and determining the critical value in the t-distribution based on the pre-set confidence level and degree of freedom.

[0141] The specific methods will not be elaborated here.

[0142] In one possible embodiment, the liquid sample processing procedure for three stability testing parameters—temperature, time, and sample packaging—is illustrated through the following three examples.

[0143] It should be noted that other factors may also affect liquid samples, and these can all be used as stability testing parameters for testing liquid samples. Other stability testing parameters will not be elaborated upon, and all factors that may affect liquid samples are included in the stability testing parameters disclosed herein.

[0144] Example 3: Temperature.

[0145] Figure 4 A flowchart illustrating a sample processing procedure in which temperature is used as a stability testing parameter, as shown in an embodiment of this disclosure, is provided. Figure 4 As shown, it includes the following steps:

[0146] S402: Determine the stability test parameter as temperature.

[0147] S404: Place the liquid sample to be processed in an environment at a first preset temperature for a first preset number of days, then place it in an environment at a second preset temperature for a second preset number of days, and then return it to room temperature to obtain a liquid sample to be tested that has passed the temperature test.

[0148] In one possible embodiment, taking water as an example of a liquid sample, the first preset temperature can be 60°C; the first preset number of days can be 3 days; the second preset temperature can be -17°C; and the second preset number of days can be 1 day.

[0149] The high-temperature environment can be an oven, and the low-temperature environment can be a refrigerator.

[0150] The time period from when the liquid sample is sent from its origin to when it reaches the participant and begins proficiency testing can be called the liquid sample distribution period.

[0151] The above method simulates whether the stability of liquid samples changes after returning to room temperature due to high or low temperatures during the distribution period.

[0152] After analyzing the radionuclides in the liquid sample to be tested that has undergone temperature testing, a stability conclusion is obtained, and the stability of the liquid sample under high and low temperature conditions is determined.

[0153] It should be noted that the first preset temperature can be any temperature value within a temperature range greater than the first temperature value. The second preset temperature can be any temperature value within a temperature range less than the second temperature value. The first and second preset number of days can be dynamically set according to the time period for distributing the liquid samples. The first temperature value is the highest temperature that the liquid sample may encounter during transportation, storage, and analysis; the second temperature value is the lowest temperature that the sample may encounter during transportation, storage, and analysis.

[0154] For example, taking water as a liquid sample, three samples are randomly selected, stored in an oven at 60°C for three days, and then frozen at -17°C for one day to obtain the liquid sample to be tested corresponding to the temperature test.

[0155] After obtaining the liquid sample to be tested, the stability conclusion corresponding to the temperature test is obtained.

[0156] Example 4: Time.

[0157] Figure 5 A flowchart illustrating a sample processing procedure in which time is used as the stability testing parameter in an embodiment of this disclosure is shown, as follows: Figure 5 As shown, it includes the following steps:

[0158] S502: Determine the stability test parameter as time.

[0159] S504: Place each liquid sample to be processed into an environment within a preset temperature range and a preset humidity range for a target time period to obtain a liquid sample to be tested that has passed the time storage test.

[0160] This includes: the start time node and the end time node.

[0161] The start time point is the time point at which each liquid sample to be processed is placed in an environment with a preset temperature range and a preset humidity range.

[0162] The end time point is the time when liquid samples are distributed to participants for proficiency testing and the testing results are obtained.

[0163] In one possible embodiment, taking water as an example of a liquid sample, the preset humidity range is less than 60%; the preset temperature range is 10℃ to 35℃.

[0164] The purpose of placing the sample within the target time period is twofold. First, it eliminates the possibility that the results obtained from proficiency testing by participants are due to long storage times. This can be understood as follows: if the stability of the liquid sample tested after the target time period is confirmed to be stable, then the length of storage time has no impact on the stability of the liquid sample, and the unexpected results obtained by participants in proficiency testing are not due to storage time. Second, the storage time can be extended; the time span for storage time testing can be up to 6 months.

[0165] For example, taking water samples as an example, three samples are randomly selected and stored in an environment where the temperature is maintained between 10°C and 35°C and the ambient humidity is less than 60%. After the participants return their results, the samples are retrieved to obtain the liquid samples to be tested for storage time.

[0166] It should be noted that this disclosure may also perform different stability test parameters separately for different rounds. For example, only temperature test may be performed for the first round, and only storage time test may be performed for the second round.

[0167] Multiple testing processes, such as storage time testing and temperature testing, can be performed simultaneously in the same round. If multiple tests are performed at the same time, liquid samples for storage time testing and temperature testing need to be directly extracted from the same batch of liquid samples.

[0168] For example, taking the simultaneous performance of multiple tests in the same round as an example, the specific methods may include:

[0169] Taking the existence of k liquid samples as an example, we can choose to use k1 samples for homogeneity testing, k2 samples for humidity testing, k3 samples for proficiency testing distribution to participants, and k4 samples for storage time testing. If other stability testing parameters need to be tested, we can continue to randomly select from the k liquid samples.

[0170] It should be noted that when randomly generating the number of the sampled liquid to be processed, the number will not be the same as the number of the previously sampled liquid to be processed.

[0171] Taking the example of drawing 4 times from k liquid samples, the specific limit for the number can be: k2 = k4 = 3. k2 is 3 randomly drawn from k-k1, and k4 is 3 randomly drawn from k-k1-k2-k3.

[0172] After obtaining the liquid sample to be tested, the stability conclusion corresponding to the storage time test is obtained.

[0173] Example 5: Sample packaging.

[0174] Figure 6 A flowchart illustrating a sample processing procedure in which the stability testing parameter is the sample packaging, as shown in an embodiment of this disclosure, is provided. Figure 6 As shown, it includes the following steps:

[0175] S602: Determine the stability test parameters for sample packaging.

[0176] S604: Set up the same sealed packaging for each liquid sample to be processed, and obtain the packaged liquid sample. The testing environment in the sealed packaging is a normal environment.

[0177] Here, "normal environment" can be understood as a situation where the temperature and humidity are both at normal temperature and normal humidity.

[0178] S606: Each liquid sample to be processed will be mailed to a preset distance via a delivery order to obtain the liquid sample to be tested.

[0179] In one possible embodiment, the sealed packaging can be a single-use plastic bottle.

[0180] By mailing delivery orders over a preset distance (which can be greater than 1000 kilometers), sufficient time is allowed for the transportation process. The liquid sample to be tested is then obtained, and corresponding analyses and measurements are performed on the sample to obtain the stability conclusions corresponding to the sample packaging inspection.

[0181] Based on the same inventive concept, this disclosure also provides a proficiency testing apparatus for liquid sample stability, as shown in the following embodiment. Since the principle by which this apparatus solves the problem is similar to that of the method embodiments described above, the implementation of this apparatus embodiment can refer to the implementation of the method embodiments described above, and repeated details will not be elaborated further.

[0182] Figure 7 This diagram illustrates the structure of a proficiency testing liquid sample stability testing device according to an embodiment of the present disclosure, as shown below. Figure 7 As shown, the proficiency testing liquid sample stability testing device 70 includes:

[0183] The acquisition unit 701 is used to acquire a preset number of liquid samples to be processed; the processing unit 702 is used to determine the stability test parameters of the liquid samples to be processed, and to place the liquid samples to be processed in the test environment corresponding to the stability test parameters to obtain the liquid samples to be tested; the stability test parameters include at least: temperature; the analysis and measurement unit 703 is used to analyze the radionuclides in the preset number of liquid samples to be tested according to the standard analysis method to obtain the average measurement value of the radionuclides in the preset number of liquid samples to be tested; the correction unit 704 is used to correct the average measurement value to the preset test date according to the half-life of the radionuclides to obtain the corrected average value; the output unit 705 is used to obtain the stability conclusion of the liquid sample under the stability test parameters according to the corrected average value.

[0184] Those skilled in the art will understand that various aspects of this disclosure can be implemented as a system, method, or program product. Therefore, various aspects of this disclosure can be specifically implemented in the following forms: a completely hardware implementation, a completely software implementation (including firmware, microcode, etc.), or a combination of hardware and software aspects, collectively referred to herein as a "circuit," "module," or "system."

[0185] The following reference Figure 8 To describe an electronic device 800 according to such an embodiment of the present disclosure. Figure 8 The electronic device 800 shown is merely an example and should not impose any limitation on the functionality and scope of use of the embodiments disclosed herein.

[0186] like Figure 8 As shown, the electronic device 800 is manifested in the form of a general-purpose computing device. The components of the electronic device 800 may include, but are not limited to: at least one processing unit 810, at least one storage unit 820, and a bus 830 connecting different system components (including storage unit 820 and processing unit 810).

[0187] The storage unit stores program code that can be executed by the processing unit 810, causing the processing unit 810 to perform the steps described in the "Exemplary Methods" section of this specification according to various exemplary embodiments of this disclosure. For example, the processing unit 810 can perform the steps of any of the above-described method embodiments.

[0188] Storage unit 820 may include a readable medium in the form of a volatile storage unit, such as random access memory (RAM) 8201 and / or cache memory 8202, and may further include a read-only memory (ROM) 8203.

[0189] The storage unit 820 may also include a program / utility 8204 having a set (at least one) of program modules 8205, including but not limited to: an operating system, one or more application programs, other program modules, and program data, each or some combination of these examples may include an implementation of a network environment.

[0190] Bus 830 can represent one or more of several types of bus structures, including a memory cell bus or memory cell controller, a peripheral bus, a graphics acceleration port, a processing unit, or a local bus using any of the various bus structures.

[0191] Electronic device 800 can also communicate with one or more external devices 840 (e.g., keyboard, pointing device, Bluetooth device, etc.), and with one or more devices that enable a user to interact with electronic device 800, and / or with any device that enables electronic device 800 to communicate with one or more other computing devices (e.g., router, modem, etc.). This communication can be performed via input / output (I / O) interface 850. Furthermore, electronic device 800 can also communicate with one or more networks (e.g., local area network (LAN), wide area network (WAN), and / or public networks, such as the Internet) via network adapter 860. As shown, network adapter 860 communicates with other modules of electronic device 800 via bus 830. It should be understood that, although not shown in the figures, other hardware and / or software modules can be used in conjunction with electronic device 800, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems.

[0192] From the above description of the embodiments, those skilled in the art will readily understand that the exemplary embodiments described herein can be implemented by software or by combining software with necessary hardware. Therefore, the technical solutions according to the embodiments of this disclosure can be embodied in the form of a software product, which can be stored in a non-volatile storage medium (such as a CD-ROM, USB flash drive, external hard drive, etc.) or on a network, including several instructions to cause a computing device (such as a personal computer, server, terminal device, or network device, etc.) to execute the methods according to the embodiments of this disclosure.

[0193] Specifically, according to embodiments of this disclosure, the processes described above with reference to the flowcharts can be implemented as a computer program product or a computer program, which includes computer instructions stored in a computer-readable storage medium. A processor of a computer device reads the computer instructions from the computer-readable storage medium and executes the computer instructions, causing the computer device to perform the methods described above.

[0194] In exemplary embodiments of this disclosure, a computer-readable storage medium is also provided, which may be a readable signal medium or a readable storage medium. A program product capable of implementing the methods described above is stored thereon. In some possible implementations, various aspects of this disclosure may also be implemented as a program product including program code, which, when run on a terminal device, causes the terminal device to perform the steps described in the "Exemplary Methods" section of this specification according to various exemplary embodiments of this disclosure.

[0195] More specific examples of computer-readable storage media in this disclosure may include, but are not limited to: electrical connections having one or more wires, portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage devices, magnetic storage devices, or any suitable combination of the foregoing.

[0196] In this disclosure, a computer-readable storage medium may include a data signal propagated in baseband or as part of a carrier wave, carrying readable program code. Such propagated data signals may take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. A readable signal medium may also be any readable medium other than a readable storage medium, capable of transmitting, propagating, or transmitting a program for use by or in connection with an instruction execution system, apparatus, or device.

[0197] Optionally, the program code contained on the computer-readable storage medium may be transmitted using any suitable medium, including but not limited to wireless, wired, optical fiber, RF, etc., or any suitable combination thereof.

[0198] In practical implementation, program code for performing the operations of this disclosure can be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java and C++, and conventional procedural programming languages ​​such as C or similar languages. The program code can execute entirely on the user's computing device, partially on the user's computing device, as a standalone software package, partially on the user's computing device and partially on a remote computing device, or entirely on a remote computing device or server. In cases involving remote computing devices, the remote computing device can be connected to the user's computing device via any type of network, including a local area network (LAN) or a wide area network (WAN), or it can be connected to an external computing device (e.g., via the Internet using an Internet service provider).

[0199] It should be noted that although several modules or units for the device used to perform actions have been mentioned in the detailed description above, this division is not mandatory. In fact, according to embodiments of this disclosure, the features and functions of two or more modules or units described above can be embodied in one module or unit. Conversely, the features and functions of one module or unit described above can be further divided and embodied by multiple modules or units.

[0200] Furthermore, although the steps of the method in this disclosure are described in a specific order in the accompanying drawings, this does not require or imply that the steps must be performed in that specific order, or that all the steps shown must be performed to achieve the desired result. Additional or alternative steps may be omitted, multiple steps may be combined into one step, and / or a step may be broken down into multiple steps.

[0201] From the above description of the embodiments, those skilled in the art will readily understand that the exemplary embodiments described herein can be implemented by software or by combining software with necessary hardware. Therefore, the technical solutions according to the embodiments of this disclosure can be embodied in the form of a software product, which can be stored in a non-volatile storage medium (such as a CD-ROM, USB flash drive, external hard drive, etc.) or on a network, including several instructions to cause a computing device (such as a personal computer, server, mobile terminal, or network device, etc.) to execute the methods according to the embodiments of this disclosure.

[0202] Other embodiments of this disclosure will readily occur to those skilled in the art upon consideration of the specification and practice of the invention disclosed herein. This disclosure is intended to cover any variations, uses, or adaptations of this disclosure that follow the general principles of this disclosure and include common knowledge or customary techniques in the art not disclosed herein. The specification and examples are to be considered exemplary only, and the true scope and spirit of this disclosure are indicated by the appended claims.

[0203] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited thereto. Various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention.

Claims

1. A capability verification liquid sample stability test method, characterized by, The method comprises the following specific steps: S202, randomly sampling a preset number of liquid samples to be processed from the liquid sample; S204, determining a stability test parameter of the liquid sample to be processed, placing the liquid sample to be processed in a test environment corresponding to the stability test parameter for processing to obtain a liquid sample to be tested; The stability test parameter at least includes temperature; S206, according to a standard analysis method, analyzing a radionuclide in a preset number of the liquid sample to be tested to obtain a measurement average value of the radionuclide in the preset number of the liquid sample to be tested; S208, according to the half-life of the radionuclide, correcting the measurement average value to a preset test date to obtain a corrected average value; S210, according to the corrected average value, obtaining a stability conclusion of the liquid sample under the stability test parameter.

2. The capability verification liquid sample stability test method according to claim 1, characterized by, The stability test parameter determined in step S204 is temperature; The liquid sample to be processed is placed in an environment of a first preset temperature for a first preset number of days, then placed in an environment of a second preset temperature for a second preset number of days, and then restored to normal temperature to obtain a liquid sample to be tested after temperature test.

3. The capability verification liquid sample stability test method according to claim 1, characterized by, The stability test parameter in step S204 further includes time; The stability test parameter is determined as time; Each of the liquid samples to be processed is placed in an environment of a preset temperature range and a preset humidity range for a target time period to obtain a liquid sample to be tested after time storage test; The target time period includes a starting time node and an ending time node; The starting time node is the time node when each of the liquid samples to be processed is placed in an environment of a preset temperature range and a preset humidity range; The ending time node is the time node when the liquid sample is delivered to a participant for capability verification and a verification result is obtained.

4. The capability verification liquid sample stability test method according to claim 1, characterized by, The stability test parameter in step S204 further includes sample packaging; The stability test parameter is determined as sample packaging; Each of the liquid samples to be processed is set with the same sealed packaging to obtain a packaged liquid sample; the test environment in the sealed packaging is a normal environment; Each of the liquid samples to be processed is mailed through a distribution order for a preset distance to obtain a liquid sample to be tested.

5. The capability verification liquid sample stability test method according to claim 1, characterized by, The stability test parameter at least further includes time and sample packaging; The method further comprises: Obtaining a first stability conclusion with the stability test parameter as temperature, a second stability conclusion with the stability test parameter as time, and a third stability conclusion with the stability test parameter as sample packaging; According to the first stability conclusion, the second stability conclusion, and the third stability conclusion, determining a stability conclusion of the liquid sample.

6. The capability verification liquid sample stability test method according to claim 1, characterized by, Step S206 further comprises the following steps: During the process of analyzing the radionuclide in a preset number of the liquid sample to be tested according to a standard analysis method, the radionuclide in each of the liquid samples to be tested is detected in parallel to obtain a measurement value of the radionuclide in each of the liquid samples to be tested; For each of the liquid samples to be tested, the radionuclide is repeatedly measured a preset number of times to obtain a measurement value of a total number of measurements; the total number of measurements is a product of the preset number of times and the preset quantity; According to the measurement value of the total number of measurements, a measurement average value is determined.

7. The capability verification liquid sample stability test method according to claim 1, characterized by, Step S210 further includes the following steps: According to the corrected average value, a statistical value is determined; A critical value for stability testing is obtained; If the statistical value is less than the critical value, it is determined that the stability of the liquid sample under the stability testing parameter is stable.

8. A device for testing the stability of a proficiency testing liquid sample according to the steps of the method of any one of claims 1 to 7, characterized in that, Comprise: An acquisition unit is configured to randomly select a preset quantity of liquid samples to be processed from a liquid sample; A processing unit is configured to determine a stability testing parameter of the liquid sample to be processed, and place the liquid sample to be processed in a testing environment corresponding to the stability testing parameter for processing to obtain a liquid sample to be tested; The stability testing parameter at least includes temperature; An analysis and measurement unit is configured to analyze a radionuclide in the preset quantity of liquid samples to be tested according to a standard analysis method to obtain a measurement average value of the radionuclide in the preset quantity of liquid samples to be tested; A correction unit is configured to correct the measurement average value to a preset testing date according to a half-life of the radionuclide to obtain a corrected average value; An output unit is configured to obtain a stability conclusion of the liquid sample under the stability testing parameter according to the corrected average value.

9. An electronic device, comprising: Comprise: A processor; And A memory is configured to store executable instructions of the processor; Wherein, the processor is configured to execute the executable instructions to perform the steps of the method of any one of claims 1-7.

10. A computer-readable storage medium having stored thereon a computer program, characterized in that, The computer program is executed by the processor to implement the steps of the method of any one of claims 1-7.

11. A computer program product, comprising: Computer program or instructions, characterized in that the computer program or instructions are executed by the processor to implement the steps of the method of any one of claims 1-7.

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