Sterile transfer equipment for freeze-dried medicine for injection and use method of sterile transfer equipment

Abstract

The invention discloses sterile transfer equipment for freeze-dried drugs for injection and a using method of the sterile transfer equipment, and relates to the technical field of material transfer. The sterile transfer equipment comprises a box body, a storage cavity is formed in the box body, and a bottom plate is mounted at the bottom of the storage cavity; first moving parts are fixedly connected to the inner walls of the surfaces of the other opposite sides, located at the position of the storage cavity, of the box body correspondingly, the moving output ends of the first moving parts are fixedly connected with a first connecting frame which is horizontally placed, and a sterilization lamp is fixedly installed below the first connecting frame; a first scanning part is fixedly connected to the middle of the top of the first connecting frame, a liquid storage box is arranged at the top of the box body, a degerming liquid is stored in the liquid storage box, a transfer lifting part is arranged on the outer side of the box door, a supporting rod is fixedly connected to the output end of the transfer lifting part, and a lifting frame is fixedly mounted at the bottom of the supporting rod; according to the equipment, intelligent transfer and sterile treatment procedures of freeze-dried medicines are realized.

Description

Technical Field

[0001] The present invention relates to the technical field of material transportation, and in particular to a sterile transportation device for injection of freeze-dried medicines and a method for using the device. Background Art

[0002] Lyophilized drugs for injection are an important form of preparation in the modern pharmaceutical industry. The production process involves multiple key links, including aseptic packaging, freeze-drying and aseptic transportation. Lyophilization technology freezes the drug solution at low temperature and then sublimates it under vacuum conditions to remove water, thereby obtaining a stable and easy-to-store powdered injection.

[0003] In the production process of freeze-dried drugs, aseptic transfer equipment plays a vital role, mainly involving canning, packaging, loading and unloading of packaging boxes, etc. Each link needs to strictly control the risk of contamination to ensure the sterility and quality of the product.

[0004] The transportation process of pharmaceutical packaging boxes can also be understood as the storage and transportation of semi-finished products. The boxes carrying the transportation packaging boxes usually need to enter different levels of clean environments for operation to ensure the sterile conditions of the transportation process. In addition, in the aseptic conversion process, human intervention is usually reduced to reduce the risk of contact for operators. However, in actual transportation, most of them still adopt macro-control of the aseptic environment and manual handling to move the pharmaceutical packaging boxes into the box. Combined with the current development needs of intelligent manufacturing, how to realize the intelligent aseptic transportation of products has become an urgent problem to be solved by people in this field. Summary of the invention

[0005] The object of the present invention is to provide a sterile transport device for freeze-dried drugs for injection and a method of using the same to solve the problems raised in the above-mentioned background technology.

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions: an aseptic transport device for freeze-dried drugs for injection, comprising a box body, the interior of the box body is configured as a storage cavity, a group of box doors are rotatably installed on the surface of one side opposite to the storage cavity, a bottom plate is installed at the bottom of the storage cavity, a first moving part is fixedly connected to the inner wall of the other side surface opposite to the storage cavity, a first connecting frame placed horizontally is fixedly connected to the moving output end of the first moving part, a sterilization lamp is fixedly installed below the first connecting frame, a first scanning part is fixedly connected to the middle of the top of the first connecting frame, a liquid storage tank is arranged on the top of the box body, and a sterilization liquid is stored in the liquid storage tank; The outer side of the box door is provided with a transfer lifting part, the output end of the transfer lifting part is fixedly connected to a support rod, the bottom of the support rod is fixedly installed with a lifting frame, a first clamping part is fixedly connected to the middle of the frame body on one side of the lifting frame close to the box body, a second clamping part is provided below the first clamping part, a first telescopic part is fixedly provided on the lifting frame above the middle of the first clamping part, the downward output end of the first telescopic part is fixedly connected to the first clamping part, and a suction part is evenly penetrated and fixedly connected to the first clamping part on all sides; A data receiving terminal is arranged on the outside of the box body or the transfer lifting part, a first data processing terminal is arranged at the transfer lifting part, a second data processing terminal is arranged on the box body, an infection monitoring part is installed on the surface of the support rod, an air inlet pipe is penetrated through the side wall of the infection monitoring part, a humidity detector is installed at the air inlet pipe, an air outlet pipe is penetrated through the top of the infection monitoring part, a partition cavity is opened on the upper part of the interior of the infection monitoring part, a monitoring cavity is opened in the middle part, a dust collection pump is connected to the lower end of the air outlet pipe inside the partition cavity, the monitoring cavity is communicated with the air inlet pipe, the suction parts are connected to the air inlet pipe, and a second scanning part and a display panel are respectively arranged on both sides of the monitoring cavity along the airflow direction.

[0007] The present invention further illustrates that a first pump body is fixedly connected to one side of the top of the first connecting frame, an input end of the first pump body is connected to a liquid storage tank through a pipeline, a plurality of first atomization parts are installed through the surface of the first connecting frame, and the plurality of first atomization parts are communicated with an output end of the first pump body.

[0008] The present invention further describes that the bottom height of the suction part is consistent with the bottom height of the first clamping part, and the diameter length of the lower end of the suction part is not less than the diameter length of the middle and upper end of the suction part, and the outer surface of the middle and upper end of the suction part penetrates and is slidably connected to the frame body of the lifting frame.

[0009] The present invention further illustrates that a pushing assembly is also provided on the lifting frame, and the pushing assembly includes a third driving part fixed on the lifting frame, the output end of the third driving part is transmission-connected with a conveyor belt, the other end of the conveyor belt is supported and connected with a supporting part, the surface of the conveyor belt located below is fixedly connected with a fixed block, the bottom surface of the fixed block is fixedly connected with a connecting block, and the bottom surface of the connecting block is fixedly connected with an L-shaped block.

[0010] The present invention further describes that the L-shaped block is fixedly connected to at least one group of second sliders on the upper surface of the lifting frame body, and a second slide rail is fixedly connected to the position of the bottom of the lifting frame body corresponding to the second slider. The second slide rail is slidably connected to the second slider, and a push block is fixedly connected to one end of the second slide rail close to the first clamping part.

[0011] The present invention further illustrates that the first data processing end is connected to the dust collecting pump, the second scanning unit, and the humidity detector signal to monitor the infection of the particle debris on the surface of the packaging box and establish an infection prediction coefficient Ψ, which indicates the degree of infection;

[0012] in, The environmental humidity is determined by the environmental influence coefficient, and the scanning area of ​​the second scanning unit is recorded as R. The second scanning unit determines the debris particle ratio by photographing the area occupied by the debris particles in the R area, which is recorded as r i , the maximum allowable proportion of debris particles is pre-set to r max , i is the serial number of the clamped packaging box.

[0013] The present invention further illustrates that a liquid pump is installed on the top of the storage cavity of the box body, and the liquid pump is connected to a flow part through a pipeline, and the flow part is connected to the liquid storage tank by a pipeline, and a sterilization tube is fixedly installed above the side wall of the storage cavity, and a plurality of second atomization parts are evenly installed on the surface of the sterilization tube facing the inside of the storage cavity, and the sterilization tube and the flow part are connected by a pipeline and a control valve is arranged on the pipeline.

[0014] The present invention further illustrates that a plurality of first grid plate groups are provided on the surface of the bottom plate, a group of third slide rails are fixedly connected to both sides of the surface of the bottom plate below the first grid plate group, a pumping box is slidably connected between the third slide rails, a pumping pipe is connected through one side of the bottom of the pumping box, the pumping pipe is connected to a dehumidification pump through a pipeline, and a switch valve is installed on the pumping pipe; A second grid plate group is arranged below the first grid plate group, the first grid plate group and the second grid plate group can be plugged in, a connecting plate is fixedly connected to the bottom surface of the second grid plate group, and a second telescopic part is fixedly connected to both sides of the connecting plate, and the second data processing end is connected to the first pump body, a one-way valve, a sterilization lamp, a liquid pump, a control valve, a dehumidification pump, a switch valve, and a second telescopic part signal.

[0015] Compared with the prior art, the beneficial effects achieved by the present invention are: By arranging the transfer lifting part, the first clamping part, the second clamping part, the suction part, the infection monitoring part, the sterilization lamp and the atomization part, on the one hand, the intelligent clamping and loading and unloading process of the medicine packaging box is realized, and on the other hand, with the help of the internal setting of the infection monitoring part, the infection situation on the surface of the packaging box is monitored, and the infection prediction coefficient is determined according to the environmental humidity and the amount of debris particles, so as to judge the degree of infection, and take corresponding supplementary sterilization measures according to the obtained infection degree, so as to improve the sterilization effect and ensure the sterilization of the box during transportation. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings: Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a structural schematic diagram of the first atomization part of the present invention; Figure 3 The present invention Figure 1 A schematic diagram of a top view structure; Figure 4 It is a structural schematic diagram of the transfer lifting part of the present invention; Figure 5 The present invention Figure 4 A schematic diagram of the enlarged structure of region A; Figure 6 It is a schematic diagram of the external structure of the infection monitoring unit of the present invention; Figure 7 The present invention Figure 6 Schematic diagram of the partial cross-section structure; Figure 8 The present invention Figure 7 Schematic diagram of the structure viewed from above; Fig. 9 is a schematic diagram of the R region of the present invention; Fig.10 It is a schematic diagram of the structure of the sterilization tube of the present invention; Fig.11 It is a schematic diagram of the connection of the pipeline of the liquid storage tank of the present invention; Fig.12 It is a schematic diagram of the bottom plate structure of the present invention; Fig.13 The present invention Fig.12 A schematic diagram of a top view structure; Fig.14 The present invention Fig.12 A schematic diagram of a side cross-section structure; Fig.15 The present invention Fig.14 A schematic diagram of the enlarged structure of region B; Fig.16 The present invention Fig.14 Schematic diagram of the closed state; Fig.17 The present invention Fig.14 A schematic diagram of the enlarged structure of the C region; In the figure: 1, box body; 2, box door; 3, first driving part; 4, bottom plate; 5, first connecting frame; 6, first moving part; 7, first sliding block; 8, first pump body; 9, sterilization lamp; 10, first atomization part; 11, liquid storage tank; 12, first scanning part; 13, transport lifting part; 14, lifting frame; 15, infection monitoring part; 151, air inlet pipe; 152, air outlet pipe; 153, compartment; 154, second driving part; 155, display board; 156, scraping part; 157, slideway; 158, slide; 159, second scanning part; 16, The second connecting frame; 17, the third driving part; 18, the conveyor belt; 19, the fixed block; 20, the supporting part; 21, the connecting block; 22, the L-shaped block; 23, the second sliding block; 24, the second slide rail; 25, the first clamping part; 26, the pushing block; 27, the second clamping part; 28, the first telescopic part; 29, the suction part; 30, the flow part; 31, the sterilization tube; 32, the control valve; 33, the third slide rail; 34, the suction box; 35, the suction tube; 36, the switch valve; 37, the first grid plate group; 38, the connecting plate; 39, the second grid plate group; 40, the second telescopic part. DETAILED DESCRIPTION

[0017] Embodiments The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0018] Example: Figure 1-Figure 5 As shown, the present invention is an aseptic transport device for freeze-dried drugs for injection, comprising a box 1, a packaging box for transporting and storing freeze-dried drugs for injection, hereinafter referred to as a packaging box, the box 1 is in a cubic shape and the interior is arranged as a storage cavity, which is convenient for stacking the packaging boxes; a group of box doors 2 are rotatably mounted on the surface of the box 1 on the opposite side of the storage cavity, wherein the number of the two box doors in a group is set to 2, and the box doors 2 are closed and opened by changing their rotation state, respectively performing the transport storage and loading and unloading processes; the box door 2 is connected to the top of one side of the box 1, and is connected to a first driving part 3 through a rod transmission, which is used to drive the rotation of the box door 2; It is also noted that rollers are installed around the bottom of the box 1 to move the box 1 to the corresponding loading and unloading location; a hand-push or electric control mode can be used, which will not be described in detail here; Figure 1 As shown, a position sensor is provided at the loading and unloading location to determine the loading and unloading position of the box body 1 and ensure the accuracy of the loading and unloading position.

[0019] A bottom plate 4 is installed at the bottom of the storage cavity in the box body 1. The bottom plate 4 can be connected by plugging, snapping, threading, etc. The upper surface of the bottom plate 4 is used to support the packaging box; among them, a linear array stacking method is preferably used.

[0020] The first moving part 6 is fixedly connected to the inner wall of the other side surface of the box body 1 at the storage cavity position. The first moving part 6 can be set as a linear motor or a screw nut mechanism that moves up and down. The first moving part 6 includes a first slide rail, and the moving output end of the first slide rail is fixedly connected to the first slider 7; like Figure 2 As shown, the top of the first slider 7 is fixedly connected to a first connecting frame 5 placed horizontally, and the first connecting frame 5 is a U-shaped structure. The first connecting frame 5 is fixedly connected to a first pump body 8 near the top of the first slider 7. The input end of the first pump body 8 is connected to a liquid storage tank 11 through a pipeline, and a one-way valve is installed on the pipeline. The liquid storage tank 11 stores a sterilizing liquid inside; the sterilizing liquid stock solution can be but is not limited to peracetic acid, ethanol, and quaternary ammonium salt disinfectants, which are mixed with water in a certain proportion to form a sterilizing liquid for sterilization treatment, thereby improving the sterilization of the transportation environment; Furthermore, a plurality of first atomizing parts 10 are installed through the surface of the first connecting frame 5. The first atomizing parts 10 can be set as an atomizer structure. The sterilizing liquid is in an atomized state when spraying, which, on the one hand, expands the sterilization coverage and has a longer suspension time, and on the other hand, reduces liquid residue and reduces the damage to the surface of the packaging box; A plurality of first atomization parts 10 are connected to the output end of the first pump body 8. When the first pump body 8 is started, the one-way valve opens. According to the set operating power, the sterilizing liquid enters the first connecting frame 5 through the pipeline and is sprayed out through the first atomization part 10 to carry out the sterilization process of the packaging box during shipment.

[0021] A sterilization lamp 9 is fixedly installed below the first connecting frame 5 for performing ultraviolet disinfection on the surface of the packaging box.

[0022] like Figure 4 , Figure 5 As shown, a transfer lifting part 13 is correspondingly arranged on the outer side of the box door 2 at the loading and unloading location. Referring to the setting of the manipulator, the transfer lifting part 13 is composed of a telescopic rod and a rotating motor, which can realize the adjustment of the height of different positions of the output end, and realize the rotation of different angles at the corresponding position height, which will not be described in detail here; the output end of the transfer lifting part 13 is fixedly connected to a support rod, and a lifting frame 14 is fixedly installed at the bottom of the support rod, and the lifting frame 14 is welded by a plurality of trusses; When the transfer lifting part 13 places the packaging box into the storage cavity of the box body 1, the lifting frame 14 is fixedly connected to the middle of the frame body on one side close to the box body 1, and a second clamping part 27 is arranged below the first clamping part 25. Specifically, the lifting frame 14 is fixed with a first telescopic part 28 above the middle of the first clamping part 25, and the downward output end of the first telescopic part 28 is fixedly connected to the first clamping part 25. The first clamping part 25 is uniformly penetrated and fixedly connected with a suction Part 29, the bottom height of the suction part 29 is consistent with the bottom height of the first clamping part 25, the suction part 29 adopts a tubular structure, and the diameter of the lower end of the suction part 29 is not less than the diameter of the middle and upper end of the suction part 29, and the outer surface of the middle and upper end of the suction part 29 passes through and is slidably connected to the frame body of the lifting frame 14; the first clamping part 25 and the bottom surface of the suction part 29 are directly in contact with the upper surface of the packaging box, and the second clamping part 27 is in contact with the lower surface of the packaging box, so as to realize the upper and lower clamping of the packaging box.

[0023] The lifting frame 14 is also provided with a pushing assembly for pushing and stacking the packaging box. The pushing assembly includes a third driving part 17 fixed on the lifting frame 14, and the third driving part 17 is arranged on the side of the lifting frame 14 away from the first telescopic part 28. The output end of the third driving part 17 is connected to the conveyor belt 18 by transmission. The other end of the conveyor belt 18 is supported and connected to the support part 20. The support part 20 includes a gear and an ear seat connected to the middle bearing of the gear. The ear seat is fixed on the frame body of the lifting frame 14. The gear and the conveyor belt 18 are connected by meshing transmission. A fixed block 19 is fixedly connected to the surface of the conveyor belt 18, a connecting block 21 is fixedly connected to the bottom of the fixed block 19, an L-shaped block 22 is fixedly connected to the bottom of the connecting block 21, at least one set of second sliders 23 are fixedly connected to the upper surface of the L-shaped block 22 facing the upper surface of the lifting frame 14, a second slide rail 24 is fixedly connected to the position of the bottom of the lifting frame 14 corresponding to the second slider 23, the second slide rail 24 is slidably connected to the second slider 23, and the movement stability of the second clamping portion 27 is ensured; a push block 26 is fixedly connected to one end of the second slide rail 24 close to the first clamping portion 25; A data receiving terminal is arranged outside the box body 1 or the transfer lifting part 13, a first data processing terminal is arranged at the transfer lifting part 13, and a second data processing terminal is arranged on the box body 1. The data receiving terminal is signal-connected with the first data processing terminal and the second data processing terminal for receiving and analyzing the received monitoring data, and outputting corresponding execution instructions to the corresponding data processing terminal to complete the aseptic transfer process.

[0024] In this embodiment, the first data processing end is signal-connected with the transfer lifting unit 13, the third driving unit 17, and the first telescopic unit 28, and executes the loading and unloading process of the packaging box through a pre-set program.

[0025] Specifically, when the box body 1 moves to the set loading location, the box door 2 remains in the open state, wherein the number of the box doors 2 on both sides that are opened is related to the number of packaging boxes placed. For the position where the box door 2 is opened, the transfer lifting part 13 drives the lifting frame 14 to move and rotate to the packaging box loading point. The packaging box loading point can be placed by manual handling or by intelligent loading method, so as to realize the clamping and unloading of the packaging box during the transfer process; the intelligent loading method is that the lifting frame 14 moves to one side of the packaging box to be clamped under program control, the second clamping part 27 maintains the longest extended state, the downward output end of the first telescopic part 28 controls the first clamping part 25 to be in the retracted state, and then the lifting frame 14 contacts the packaging box to the lower surface of the packaging box under the drive of the transfer lifting part 13, and the downward output end of the first telescopic part 28 controls the first clamping part 25 to move downward to the extended state, so as to realize the clamping of the packaging box by the lifting frame 14; Then, the container is moved to the unloading point of the packaging box set on the bottom plate 4 to unload. Specifically, during unloading, the suction part 29 maintains the suction state and applies suction force to the upper surface of the packaging box. When the packaging box is above the unloading point, the pushing component is started, that is, the third driving part 17 is started to Figure 4 For example, the conveyor belt 18 is driven in a clockwise direction, and the transmission belt 18 drives the second clamping part 27 to retract through the connected fixed block 19, the connecting block 21, and the L-shaped block 22, and under the blocking action of the push block 26, until the second clamping part 27 is no longer in contact with the packaging box, at a preset height, the first telescopic part 28 drives the first clamping part 25 and the suction part 29 to move downward. After being stably placed at the bottom of the packaging box, the suction part 29 stops suction, and the first telescopic part 28 returns to the retracted state, thereby completing the loading and unloading process of the packaging box.

[0026] During the loading process, the sterilization lamp 9 is used as needed. In addition, the first movable part 6 can be adjusted in height synchronously according to the height of the package box moved during loading. During the unloading process of the package box, the sterilization lamp 9 can sterilize the package box from bottom to top with the maximum irradiation area. After the package box is placed stably, the sterilization lamp 9 remains at a position not lower than the height of the upper surface of the package box and prepares for the irradiation and sterilization of the next package box.

[0027] like Figure 6-Figure 8 As shown, an infection monitoring unit 15 is installed on the surface of the support rod above the lifting frame 14, and a second connecting frame 16 is fixedly connected to the back of the infection monitoring unit 15, and the second connecting frame 16 is fixedly installed on the support rod to complete the fixed installation of the infection monitoring unit 15; like Figure 6 As shown, the side wall of the infection monitoring unit 15 is connected with an air inlet pipe 151, and a humidity detector is installed at the air inlet pipe 151. The top of the infection monitoring unit 15 is connected with an air outlet pipe 152. Figure 7As shown, a compartment 153 is provided at the upper part of the infection monitoring part 15, a monitoring chamber is provided at the middle part of the interior, a dust collecting pump is provided at the lower end of the air outlet pipe 152 in the compartment 153, the input end of the dust collecting pump passes through the bottom of the compartment 153 through a pipeline and communicates with the monitoring chamber, the monitoring chamber communicates with the air inlet pipe 151, the above-mentioned suction parts 29 are connected to the air inlet pipe 151, and the dust collecting pump can provide the suction force required by the suction part 29; like Figure 8 As shown, the second scanning unit 159 and the display panel 155 are respectively arranged on both sides of the monitoring cavity along the airflow direction; Fig. 9 As shown, the scanning area of ​​the second scanning unit 159 is denoted as R. The second scanning unit 159 determines the debris particle ratio by photographing the area occupied by the debris particles in the R area, which is denoted as r. i , i is the serial number of the clamped packaging box, and the maximum proportion of the allowed debris particles is preset to r max During the period when the first telescopic portion 28 controls the first clamping portion 25 to move downward to the extended state, the dust collecting pump is started and absorbs the ambient air near the packaging box. After the clamping is completed, the suction process is suspended, and then the debris particle ratio coefficient is obtained.

[0028] In this embodiment, the first data processing end is also connected to the dust collecting pump, the second scanning unit 159, and the humidity detector signal to monitor the infection of the particle debris on the surface of the packaging box and establish an infection prediction coefficient Ψ to indicate the degree of infection;

[0029] in, It is determined by the ambient humidity, recorded as the environmental impact coefficient. The real-time humidity measured by the humidity detector is recorded as Si, and the maximum humidity that the freeze-dried drug can adapt to is recorded as Smax. It should be noted that the humidity of the transportation environment in most warehouses or workshops is controllable, but there is also a phenomenon that the ambient humidity cannot be macro-controlled, so the environmental impact coefficient is established. ; When Si≤Smax, Take 1, the environment belongs to normal humidity state; when Si>Smax, If -1 is selected, the environment is in a high humidity state; Therefore, the infection prediction coefficient Ψ is determined by the environmental impact coefficient and the debris particle ratio coefficient. The first data processing end transmits the infection prediction coefficient to the data receiving end. The data receiving end predicts the infection degree on the surface of the packaging box according to the infection prediction coefficient, and transmits the treatment measures to the second data processing end. According to the obtained infection degree, corresponding supplementary sterilization measures are taken to improve the sterility level during transportation.

[0030] Furthermore, a transparent cover is installed on the side of the scanning end of the second scanning unit 159 facing the inside of the monitoring cavity, preferably made of glass, to facilitate cleaning of debris particles at the scanning end; a lamp bead for brightening is installed in the middle of the display panel 155 to improve the clarity of the scanning result.

[0031] A group of scraping parts 156 are also provided inside the monitoring chamber for cleaning the transparent shield and the surface of the display panel 155. The upper and lower ends of the scraping parts 156 are slidably connected with a slide groove 157, and the slide groove 157 is fixed on the inner wall of the monitoring chamber. A slide 158 is fixedly connected between the tops of the group of scraping parts 156. The middle part of the slide 158 is rotatably connected with a screw structure, and one end of the screw is fixedly connected with the second driving part 154. After the particle monitoring of the packaging box marked i is completed, if If the value is lower than a preset comparison parameter, usually not higher than 0.5, the second driving unit 154 will not start; otherwise, the second driving unit 154 will start to perform the scraping process. When the airflow flows next time, the particles are extracted and separated from the airflow under the action of the dust collecting pump. For example, the compartment 153 is provided with a space for storing debris particles, and the airflow is discharged from the air outlet pipe 152. This is a conventional debris filtering and isolation process when the dust collecting pump is used, which will not be elaborated here, and is intended to achieve clean outflow of airflow and collection of debris.

[0032] like Fig.10 As shown, a liquid pump is installed on the top of the storage chamber of the box body 1, and the liquid pump is connected to the flow part 30 through a pipeline. The flow part 30 is connected to the liquid storage tank 11 by a pipeline, and a sterilization tube 31 is fixedly installed on the top of the side wall of the storage chamber. A plurality of second atomization parts are evenly installed on the surface of the sterilization tube 31 facing the inside of the storage chamber. The sterilization tube 31 is connected to the flow part 30 by a pipeline and a control valve 32 is provided on the pipeline to control the output state of the sterilization liquid.

[0033] like Figure 12-14 As shown, a plurality of first grid plate groups 37 are provided on the surface of the bottom plate 4, and the first grid plate group 37 is arranged in an array with a certain gap. A group of third slide rails 33 are fixedly connected to both sides of the surface of the bottom plate 4 below the first grid plate group 37, and a pumping box 34 is slidably connected between the third slide rails 33. A pumping pipe 35 is connected through one side of the bottom of the pumping box 34, and the pumping pipe 35 is connected to a dehumidification pump through a pipeline. A switch valve 36 is installed on the pumping pipe 35 to control the connection state of the pumping pipe 35; Furthermore, a second grid plate group 39 is provided below the first grid plate group 37. The second grid plate group 39 is composed of a plurality of second grids arranged in an array with a certain gap, and the first grid plate group 37 can be completely plugged into the second grid plate group 39 to fill the gap, so that the bottom plate 4 has a flat upper surface without gaps; preferably, the positions of the first grid and the second grid are staggered, and the cross-section is a trapezoidal structure; The bottom surface of the second grid plate group 39 is fixedly connected to a connecting plate 38, and the two sides of the connecting plate 38 are fixedly connected to the second telescopic portion 40. Through the extension and contraction of the second telescopic portion 40, the first grid plate group 37 and the second grid plate group 39 switch the separation and closing states of the bottom plate 4; Fig.15 As shown, the bottom plate 4 is in a separated state, and the airflow containing the atomized sterilizing liquid in the box body 1 can be discharged from the suction pipe 35 through the gap between the first grid plate group 37 and the second grid plate group 39, as shown in FIG. Fig.16 , Fig.17 As shown, the bottom plate 4 is in a closed state, and the air flow cannot flow out through the bottom plate 4.

[0034] In this embodiment, the second data processing end is signal-connected to the first pump body 8, the one-way valve, the sterilization lamp 9, the liquid pump, the control valve 32, the dehumidification pump, the switch valve 36, and the second telescopic part 40; In addition, a first scanning unit 12 is fixedly connected to the top middle of the first connecting frame 5 for monitoring moisture on the surface of the packaging box during the sterilization process; it can be combined with the above-mentioned supplementary sterilization measures to ensure the normal storage state of the packaging box in the box body 1.

[0035] Specifically, a qualified infection coefficient ∂1 and a severe infection coefficient ∂2 are established, 0<∂1≤1, -1≤∂2<0, the qualified infection coefficient ∂1 is used to judge the degree of infection under normal environmental conditions, and the severe infection coefficient ∂2 is used to judge the degree of infection under high humidity environments; When Ψ=0, it means that the environment has reached an ideal sterile environment and no additional sterilization measures are needed. During the transportation of the packaging box, the sterilization lamp 9 is at the top of the box body 1 and lights up, and conventional sterilization is performed on the box body 1, and the bottom plate 4 is in a closed state; When 0<Ψ≤∂1, it indicates that the environmental humidity is normal and the infection level is low. During the transportation of the packaging box, the germ lamp 9 is at the top of the box body 1 and lights up, and the sterilization tube 31 sprays a first-level quantitative atomized sterilization liquid downward to enhance the sterilization effect, which is reflected by the spraying time. The bottom plate 4 is in a separated state, and the dehumidification pump is started with the primary power to accelerate the flow of atomized molecules and improve the sterilization effect. When Ψ>∂1, it indicates that the environmental humidity is normal and the infection degree is high. During the transportation of the packaging box, the sterilization lamp 9 is at the top position in the box body 1 and lights up, and the sterilization tube 31 sprays the secondary quantitative atomized sterilization liquid downward, wherein the secondary quantitative is higher than the primary quantitative, and the sterilization lamp 9 is at the top position in the box body 1 and lights up. In addition, the bottom plate 4 is in a separated state, and the dehumidification pump is started at a high power to further accelerate the flow and discharge of the atomized molecules, which not only improves the sterilization effect, but also prevents the atomized molecules from staying on the surface of the packaging box for too long, thereby accelerating the drying speed after sterilization; When ∂2≤Ψ<0, it means that the environment is in high humidity and the infection degree is low. The high humidity environment will reduce the sterilization effect of the sterilization lamp 1. Therefore, in order to ensure its sterilization effect, the sterilization lamp 9 follows the position of the packaging box at the loading point to adjust the height synchronously; the sterilization pipe 31 stops spraying the sterilization liquid to avoid excessive increase in environmental humidity. In addition, the first pump body 8 is started with primary power, and the first atomization part 10 accurately realizes enhanced sterilization of the surface of the packaging box by following the operation of the sterilization lamp 9. The bottom plate 4 is in a separated state, and the dehumidification pump is started with primary power; When Ψ<∂2, it indicates that the environment is in high humidity and the infection degree is high. Therefore, the sterilization lamp 9 adjusts its height synchronously with the position of the packaging box at the loading point, the sterilization pipe 31 stops spraying the sterilization liquid, the first pump body 8 starts at high power, the bottom plate 4 is in a separated state, and the dehumidification pump starts at high power to improve the sterilization effect.

[0036] In addition, when the first pump body 8 is started, the first scanning unit 12 monitors the moisture phenomenon on the surface of the packaging box, that is, after the sterilization liquid is sprayed, the first scanning unit 12 obtains the moisture points on the surface of the packaging box that can be measured. If there are moisture points, the second data processing end will transmit the moisture data to the data receiving end and perform alarm processing to prevent the packaging box from getting damp and rotting, which will affect the medicines.

[0037] According to the above-mentioned method for using the sterile transport device for injectable freeze-dried drugs, the specific contents are as follows: S1: Box 1 moves to the set loading location and clamps the packaging box; S2: When the first telescopic portion 28 controls the first clamping portion 25 to move downward, the dust collecting pump is started, and the first data processing end monitors the infection status of the particles and debris on the surface of the packaging box and establishes an infection prediction coefficient; S3: The first data processing end transmits the infection prediction coefficient to the data receiving end, and the data receiving end predicts the infection degree of the surface of the packaging box according to the infection prediction coefficient, and transmits the treatment measures to the second data processing end; S4: After the lifting frame 14 completes clamping the packaging box, it moves to the unloading point for unloading; S5: During unloading, the second data processing terminal performs corresponding supplementary sterilization measures according to the obtained infection degree, so as to improve the sterilization effect and ensure the aseptic transportation of the box 1.

[0038] In the description of the present invention, it is necessary to understand that the terms "up", "down", "front", "back", "left", "right", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention.

[0039] Finally, it should be pointed out that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them. Although the present invention has been described in detail with reference to the above embodiments, a person skilled in the art should understand that the technical solutions described in the above embodiments can still be modified, or some of the technical features can be replaced by equivalents, and these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A sterile transport device for freeze-dried drugs for injection, comprising a box body (1), the interior of the box body (1) is arranged as a storage cavity, and a set of box doors (2) are rotatably mounted on the surface of one side of the box body (1) opposite to the storage cavity, characterized in that: A bottom plate (4) is installed at the bottom of the storage cavity; a first moving part (6) is fixedly connected to the inner wall of the other opposite side surface of the box body (1) located at the storage cavity; a moving output end of the first moving part (6) is fixedly connected to a first connecting frame (5) placed horizontally; a sterilization lamp (9) is fixedly installed below the first connecting frame (5); a first scanning part (12) is fixedly connected to the middle of the top of the first connecting frame (5); a liquid storage tank (11) is arranged on the top of the box body (1); a sterilization liquid is stored in the liquid storage tank (11); A transfer lifting part (13) is arranged on the outer side of the box door (2), the output end of the transfer lifting part (13) is fixedly connected to a support rod, a lifting frame (14) is fixedly installed on the bottom of the support rod, a first clamping part (25) is fixedly connected to the middle of the lifting frame (14) on one side close to the box body (1), a second clamping part (27) is arranged below the first clamping part (25), a first telescopic part (28) is fixedly arranged above the middle of the lifting frame (14) located in the middle of the first clamping part (25), the downward output end of the first telescopic part (28) is fixedly connected to the first clamping part (25), and a suction part (29) is evenly penetrated and fixedly connected to the periphery of the first clamping part (25); A data receiving terminal is arranged outside the box (1) or the transfer lifting part (13), a first data processing terminal is arranged at the transfer lifting part (13), a second data processing terminal is arranged on the box (1), an infection monitoring part (15) is installed on the surface of the support rod, an air inlet pipe (151) is connected through the side wall of the infection monitoring part (15), a humidity detector is installed at the air inlet pipe (151), an air outlet pipe (152) is connected through the top of the infection monitoring part (15), a partition (153) is opened at the upper part of the infection monitoring part (15), a monitoring chamber is opened in the middle part of the interior, a dust collecting pump is arranged in the interior of the partition (153) at the lower end of the air outlet pipe (152), the monitoring chamber is in communication with the air inlet pipe (151), the suction part (29) is connected to the air inlet pipe (151), and a second scanning part (159) and a display panel (155) are respectively arranged on both sides of the monitoring chamber along the air flow direction.

2. The aseptic transport device for freeze-dried drugs for injection according to claim 1, characterized in that: A first pump body (8) is fixedly connected to one side of the top of the first connecting frame (5); an input end of the first pump body (8) is connected to a liquid storage tank (11) via a pipeline; a plurality of first atomizing parts (10) are installed through the surface of the first connecting frame (5); and the plurality of first atomizing parts (10) are in communication with an output end of the first pump body (8).

3. The aseptic transport device for freeze-dried drugs for injection according to claim 1, characterized in that: The bottom height of the suction portion (29) is consistent with the bottom height of the first clamping portion (25), and the diameter of the lower end of the suction portion (29) is not less than the diameter of the middle and upper end of the suction portion (29). The outer surface of the middle and upper end of the suction portion (29) penetrates through and is slidably connected to the frame body of the lifting frame (14).

4. The aseptic transport device for freeze-dried drugs for injection according to claim 1, characterized in that: The lifting frame (14) is also provided with a pushing assembly, and the pushing assembly includes a third driving part (17) fixed on the lifting frame (14); the output end of the third driving part (17) is drivingly connected to a conveyor belt (18); the other end of the conveyor belt (18) is supported and connected to a supporting part (20); the surface of the conveyor belt (18) located below is fixedly connected to a fixed block (19); the bottom surface of the fixed block (19) is fixedly connected to a connecting block (21); and the bottom surface of the connecting block (21) is fixedly connected to an L-shaped block (22).

5. The aseptic transport device for freeze-dried drugs for injection according to claim 1, characterized in that: The L-shaped block (22) is fixedly connected to at least one set of second sliding blocks (23) on the upper surface of the lifting frame (14), and a second slide rail (24) is fixedly connected to the bottom of the lifting frame (14) at a position corresponding to the second sliding block (23). The second slide rail (24) is slidably connected to the second sliding block (23), and a push block (26) is fixedly connected to one end of the second slide rail (24) close to the first clamping portion (25).

6. The aseptic transport device for freeze-dried drugs for injection according to claim 2, characterized in that: The first data processing end is connected to the dust collection pump, the second scanning unit (159), and the humidity detector signal to monitor the infection status of the particles on the surface of the packaging box and establish an infection prediction coefficient Ψ, which represents the degree of infection: in, The environmental humidity is determined by the environmental influence coefficient, the scanning area of ​​the second scanning unit (159) is recorded as R, and the second scanning unit (159) determines the debris particle ratio coefficient by photographing the area occupied by the debris particles in the R area, recorded as r i , the maximum allowable proportion of debris particles is pre-set to r max , i is the serial number of the clamped packaging box.

7. The aseptic transport device for freeze-dried drugs for injection according to claim 6, characterized in that: A liquid pump is installed at the top of the storage chamber of the box body (1), and the liquid pump is connected to a flow portion (30) via a pipeline. The flow portion (30) is connected to the liquid storage box (11) via a pipeline. A sterilization tube (31) is fixedly installed above the side wall of the storage chamber, and a plurality of second atomization portions are evenly installed on the surface of the sterilization tube (31) facing the inside of the storage chamber. The sterilization tube (31) is connected to the flow portion (30) via a pipeline, and a control valve (32) is provided on the pipeline.

8. The aseptic transport device for freeze-dried drugs for injection according to claim 7, characterized in that: A plurality of first grid plate groups (37) are provided on the surface of the bottom plate (4); a group of third slide rails (33) are fixedly connected to both sides of the surface of the bottom plate (4) below the first grid plate group (37); a pumping box (34) is slidably connected between the third slide rails (33); a pumping pipe (35) is connected through one side of the bottom of the pumping box (34); the pumping pipe (35) is connected to a dehumidification pump via a pipeline; and a switch valve (36) is installed on the pumping pipe (35); A second grid plate group (39) is arranged below the first grid plate group (37); the first grid plate group (37) and the second grid plate group (39) are pluggable; a connecting plate (38) is fixedly connected to the bottom surface of the second grid plate group (39); second telescopic parts (40) are fixedly connected to both sides of the connecting plate (38); and the second data processing end is signal-connected to the first pump body (8), the one-way valve, the sterilization lamp (9), the liquid pump, the control valve (32), the dehumidification pump, the switch valve (36), and the second telescopic part (40).

9. The aseptic transport device for freeze-dried drugs for injection according to claim 6, characterized in that: A transparent shield is installed on the side of the scanning end of the second scanning unit (159) facing the inside of the monitoring chamber, a lamp bead is installed in the middle of the display panel (155), and a group of scraping units (156) are also arranged inside the monitoring chamber, and the scraping units (156) are transmission-connected to the second driving unit (154).

10. The method for using the sterile transport device for freeze-dried drugs for injection according to claim 8, characterized in that: Here’s how: S1: The box body (1) moves to the set loading location and clamps the packaging box; S2: When the first telescopic portion (28) controls the first clamping portion (25) to move downward, the dust collection pump is started, and the first data processing end monitors the infection status of the particle debris on the surface of the packaging box and establishes an infection prediction coefficient; S3: The first data processing end transmits the infection prediction coefficient to the data receiving end, and the data receiving end predicts the infection degree of the surface of the packaging box according to the infection prediction coefficient, and transmits the treatment measures to the second data processing end; S4: After the lifting frame (14) completes clamping the packaging box, it moves to the unloading point for unloading; S5: During unloading, the second data processing end performs corresponding supplementary sterilization measures according to the obtained infection degree, so as to improve the sterilization effect and ensure the aseptic transportation of the box (1).

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