Pharmaceutical composition for treating skin ulceration and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a pharmaceutical composition for treating skin ulceration and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 45 to 55g of radix astragali seu hedysari, 20 to 30g of frankincense, 23 to 27g of myrrh, 28 to 32g of radix scutellariae, 24 to 26g of rhizoma coptidis, 28 to 32g of cortex phellodendri, 23 to 27g of raw radix et rhizoma rhei, 24 to 26g of cooked radix et rhizoma rhei, 18 to 22g of honeycomb, 7 to 9g of dragon's blood, 8 to 12g of snake slough, 14 to 16g of rhizoma bletillae, 17 to 23g of radix ampelopsis, 1 to 2g of borneol, 9 to 11g of borax, 8 to 12g of catechu, 28 to 32g of herba portulacae and 49 to 51g of crucible powder. The medicine composition prepared through processing has multiple functions of clearing away heat and toxic materials, removing necrotic tissue and promoting granulation, promoting blood circulation to remove blood stasis, stopping bleeding and relieving pain, diminishing swelling and relieving itching, fading scars and the like, and can effectively treat skin ulcers and burns and scalds caused by pressure sores, sitting sores, bedsore ulcers and various reasons.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a pharmaceutical composition for treating skin ulcers and a preparation method thereof. Background Art

[0002] Skin ulcers are a common and difficult-to-cure surgical disease that not only causes great physical pain to patients, but also seriously affects their quality of life. This type of disease usually occurs in people who are bedridden, have difficulty in moving, or suffer from chronic diseases. Due to long-term pressure, friction, or external stimulation on the skin, the skin tissue is damaged, which in turn causes infection and inflammation, forming ulcers.

[0003] At present, although there are many therapeutic drugs for skin ulcers on the market, their efficacy varies and there are many shortcomings. For example, although some chemical synthetic drugs have rapid anti-inflammatory and analgesic effects, long-term use often irritates the skin and even causes allergic reactions; while some traditional Chinese medicine preparations are relatively safe, but the efficacy is relatively slow, and the preparation process is complicated, which is not conducive to large-scale production and promotion.

[0004] In traditional Chinese medicine theory, skin ulcers are mostly caused by invasion of damp-heat toxic evils and stagnation of qi and blood. Therefore, treatment should focus on the principles of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, removing dead tissue and promoting tissue regeneration. In recent years, with the continuous deepening of traditional Chinese medicine research, more and more Chinese herbal medicines have been confirmed to have pharmacological effects such as antibacterial, anti-inflammatory, and promoting tissue repair, providing new ideas and methods for the treatment of skin ulcers. Based on this, it is particularly important to develop a skin ulcer treatment drug with significant efficacy, high safety, simple preparation process and easy promotion. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a pharmaceutical composition for treating skin ulcers and a preparation method thereof.

[0006] To solve the above technical problems, the technical solution provided by the present invention is a pharmaceutical composition for treating skin ulcers, which comprises the following raw materials in parts by weight: 45-55g of astragalus, 20-30g of frankincense, 23-27g of myrrh, 28-32g of scutellaria, 24-26g of coptis, 28-32g of phellodendron, 23-27g of raw rhubarb, 24-26g of cooked rhubarb, 18-22g of honeycomb, 7-9g of dragon's blood, 8-12g of snake skin, 14-16g of bletilla striata, 17-23g of white ampel, 1-2g of borneol, 9-11g of borax, 8-12g of catechu, 28-32g of purslane, and 49-51g of earth crucible powder.

[0007] Furthermore, the pharmaceutical composition includes the following raw materials in parts by weight: 50g of astragalus, 25g of frankincense, 25g of myrrh, 30g of scutellaria, 25g of coptis, 30g of phellodendron, 25g of raw rhubarb, 25g of cooked rhubarb, 20g of honeycomb, 8g of dragon's blood, 10g of snake skin, 15g of bletilla striata, 20g of white ampel, 1.5g of borneol, 10g of borax, 10g of catechu, 30g of purslane, and 50g of earth crucible powder.

[0008] Furthermore, the earthen crucible powder is a fine powder obtained by crushing, grinding and passing through a 100-mesh sieve of a forged copper and silver earthen crucible.

[0009] Furthermore, the preparation method of the pharmaceutical composition comprises the following steps:

[0010] Step 1) respectively taking the above raw materials, grinding them into fine powder, passing through a 100-mesh sieve, and obtaining fine powder of each raw material for later use;

[0011] Step 2) Take the fine powder of each raw material by weight, mix them evenly and set aside.

[0012] Step 3) taking an appropriate amount of rapeseed oil, adding the uniformly mixed drug powder thereto, and fully blending the drug and the oil to form a uniform paste;

[0013] Step 4) Pour the prepared drug paste into a copper pot, heat to 100°C, and keep for 1-2 minutes to ensure that the drug ingredients are fully integrated and exert the best efficacy. Stir constantly during the heating process to prevent the paste from burning;

[0014] Step 5) After the drug paste is cooled naturally to room temperature, it can be bottled and stored.

[0015] The sources of raw materials used in the present invention are as follows:

[0016] Astragalus: tonifies Qi and raises Yang, consolidates the exterior and stops sweating, promotes diuresis and reduces swelling, promotes fluid production and nourishes blood, relieves stagnation and arthritis, expels toxins and discharges pus, and heals sores and promotes tissue regeneration.

[0017] Frankincense and myrrh: promote blood circulation and relieve pain, reduce swelling and promote tissue regeneration. They are used for various pain syndromes caused by blood stasis and the initial stage of sores, carbuncles, or pus that has not yet ulcerated.

[0018] Scutellaria baicalensis, Coptis chinensis, and Phellodendron amurense: All of them are heat-clearing and dampness-drying medicines, with the effects of clearing heat and dampness, purging fire and detoxifying, and are used for damp-heat diarrhea, jaundice, hot stranguria, eczema, etc.

[0019] Raw rhubarb and cooked rhubarb: have a laxative effect, clear away heat and purge fire, cool blood and detoxify, remove blood stasis and dredge menstruation, and remove dampness and jaundice. Cooked rhubarb has a mild laxative effect and a stronger blood circulation effect.

[0020] Honeycomb: It can attack toxins and kill insects, dispel wind and relieve pain. It is used for sores, swellings, mastitis, scrofula, stubborn skin tinea, etc.

[0021] Xuejie: ​​promotes blood circulation and relieves pain, removes blood stasis and stops bleeding, heals sores and promotes tissue regeneration. It is used for bruises, pain in the heart and abdomen caused by blood stasis, bleeding from trauma, and sores that do not heal.

[0022] Snake skin: dispels wind, calms the nerves, detoxifies, and removes cataracts. It is used for children's convulsions, convulsions, cataracts in the throat, skin itching, etc.

[0023] Bletilla striata and Bletilla striata: Both are astringent hemostatic drugs with the effects of astringent hemostasis, swelling reduction and tissue regeneration. They are used for hemoptysis, hematemesis, traumatic bleeding, sores and swelling, etc.

[0024] Borneol: It can invigorate the mind, clear away heat and relieve pain. It is used for coma caused by febrile disease, convulsions, syncope caused by phlegm, sudden syncope caused by qi stagnation, coma caused by poisoning, etc.

[0025] Borax: clears away heat and detoxifies. It can be used for preservation, detoxification and tissue regeneration when applied externally. It is used for sore throat, mouth sores, red eyes and cataracts, etc.

[0026] Catechu: absorbs dampness and heals sores, promotes fluid production and stops bleeding, clears the lungs and resolves phlegm. It is used for eczema, wet sores, ulcers that do not heal, vomiting blood, nosebleeds, etc.

[0027] Portulaca oleracea: clears away heat and detoxifies, cools blood and stops bleeding, and stops dysentery. It is used for heat-toxic bloody dysentery, carbuncles, furuncles, eczema, erysipelas, etc.

[0028] The advantages of the present invention compared with the prior art are:

[0029] The pharmaceutical composition of the present invention has multiple functions such as clearing away heat and detoxifying, removing dead tissue and promoting tissue regeneration, promoting blood circulation and removing blood stasis, stopping bleeding and relieving pain, reducing swelling and relieving itching, and fading scars. Through the multiple action mechanisms such as clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, stopping bleeding and relieving pain, the pharmaceutical composition of the present invention effectively improves the microenvironment of the skin ulcer site, promotes inflammation regression and tissue repair, can effectively treat bedsores, scalds, bedsores, and skin ulcers caused by various reasons, and can also be used for the treatment of burns and scalds, with significant clinical efficacy and broad application prospects. DETAILED DESCRIPTION

[0030] The following is a further detailed description of a pharmaceutical composition for treating skin ulcers and a preparation method thereof according to the present invention in conjunction with examples.

[0031] Example 1

[0032] A pharmaceutical composition for treating skin ulcers, comprising the following raw materials in parts by weight: 50g of astragalus, 25g of frankincense, 25g of myrrh, 30g of scutellaria, 25g of coptis root, 30g of phellodendron, 25g of raw rhubarb, 25g of cooked rhubarb, 20g of honeycomb, 8g of dragon's blood, 10g of snake skin, 15g of white striata, 20g of white ampel, 1.5g of borneol, 10g of borax, 10g of catechu, 30g of purslane, and 50g of earth crucible powder;

[0033] The earthen crucible powder is the fine powder obtained by crushing, grinding and passing through a 100-mesh sieve of forged copper and silver earthen crucible;

[0034] The preparation method of the pharmaceutical composition comprises the following steps:

[0035] Step 1) respectively taking the above raw materials, grinding them into fine powder, passing through a 100-mesh sieve, and obtaining fine powder of each raw material for later use;

[0036] Step 2) Take the fine powder of each raw material by weight, mix them evenly and set aside.

[0037] Step 3) taking an appropriate amount of rapeseed oil, adding the uniformly mixed drug powder thereto, and fully blending the drug and the oil to form a uniform paste;

[0038] Step 4) Pour the prepared drug paste into a copper pot, heat to 100°C, and keep for 1 minute to ensure that the drug ingredients are fully integrated and exert the best efficacy. Stir continuously during the heating process to prevent the paste from burning;

[0039] Step 5) After the drug paste is cooled naturally to room temperature, it can be bottled and stored.

[0040] Usage: For external use, clean the affected area before use, apply the drug group to the affected area, then wrap it with clean gauze, and change the medicine every 4-5 days.

[0041] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A pharmaceutical composition for treating skin ulcers, characterized in that: The pharmaceutical composition comprises the following raw materials in parts by weight: 45-55g of astragalus, 20-30g of frankincense, 23-27g of myrrh, 28-32g of scutellaria, 24-26g of coptis, 28-32g of phellodendron, 23-27g of raw rhubarb, 24-26g of cooked rhubarb, 18-22g of honeycomb, 7-9g of dragon's blood, 8-12g of snake skin, 14-16g of bletilla striata, 17-23g of white ampel, 1-2g of borneol, 9-11g of borax, 8-12g of catechu, 28-32g of purslane and 49-51g of earth crucible powder.

2. The pharmaceutical composition according to claim 1, characterized in that: The pharmaceutical composition comprises the following raw materials in parts by weight: 50g of astragalus, 25g of frankincense, 25g of myrrh, 30g of scutellaria, 25g of coptis, 30g of phellodendron, 25g of raw rhubarb, 25g of cooked rhubarb, 20g of honeycomb, 8g of dragon's blood, 10g of snake skin, 15g of bletilla striata, 20g of white ampel, 1.5g of borneol, 10g of borax, 10g of catechu, 30g of purslane, and 50g of earth crucible powder.

3. The pharmaceutical composition according to claim 1 or 2, characterized in that: The earthen crucible powder is a fine powder obtained by crushing, grinding and passing through a 100-mesh sieve of a forged copper and silver earthen crucible.

4. The method for preparing the pharmaceutical composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1) respectively taking the above raw materials, grinding them into fine powder, passing through a 100-mesh sieve, and obtaining fine powder of each raw material for later use; Step 2) Take the fine powder of each raw material by weight, mix them evenly and set aside. Step 3) taking an appropriate amount of rapeseed oil, adding the uniformly mixed drug powder thereto, and fully blending the drug and the oil to form a uniform paste; Step 4) Pour the prepared drug paste into a copper pot, heat to 100°C, and keep for 1-2 minutes to ensure that the drug ingredients are fully integrated and exert the best efficacy. Stir constantly during the heating process to prevent the paste from burning; Step 5) After the drug paste is cooled naturally to room temperature, it can be bottled and stored.