Anti-arrhythmia traditional Chinese medicine composition

By adding trace elements such as magnesium, potassium, zinc and selenium to the anti-arrhythmia Chinese medicine composition, combined with ingredients such as syrup, Panax notoginseng and lidocaine, the problem of drug conflicts and difficulty in long-term conditioning of existing Chinese medicine compositions is solved, and stable and gentle treatment of heart rate arrhythmia is achieved.

CN119925523APending Publication Date: 2025-05-06HEILONGJIANG UNIV OF CHINESE MEDICINE
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Patent Information

Application Number
CN202311447838.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-11-02
Publication Date
2025-05-06

AI Technical Summary

Technical Problem

The existing anti-arrhythmia Chinese medicine compositions have drug conflicts in the treatment of heart rate abnormalities, making it difficult to regulate the body for a long time, and do not conform to the concept of the monarch, minister and assistant to the Chinese medicine, which may cause harm to the patient's body.

Method used

An anti-arrhythmic Chinese medicine composition is adopted, including a Class A Chinese medicinal material extract and a Class B auxiliary mixture. Through the combination of trace elements such as magnesium, potassium, zinc and selenium, the rhythm of the heart and the expansion of blood vessels are regulated, the blood supply of the heart is improved, and the repair and growth of heart muscles are promoted.

Benefits of technology

It has achieved the effect of not only being used for short-term emergency treatment of heart rate arrhythmia, but also being taken for a long time to regulate the body, avoiding drug conflicts and stably providing mild treatment to patients with heart rate arrhythmia.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses an anti-arrhythmia traditional Chinese medicine composition, which is prepared by the following steps: step 1, preparing A-type traditional Chinese medicine extract materials: respectively preparing salvia miltiorrhiza, honeysuckle, uncaria, poria cocos, radix ophiopogonis and gastrodia elata according to a weight ratio; step 2, crushing the radix salviae miltiorrhizae, the poria cocos, the radix ophiopogonis and the gastrodia elata in the step 1 into powder with the particle diameter of 15-20 microns, and uniformly mixing the powder and the radix salviae miltiorrhizae, the poria cocos, the radix ophiopogonis and the gastrodia elata; step 3, respectively putting honeysuckle and uncaria into a boiler for boiling according to the ratio of liquid medicine to 50: 1, filtering the medicinal materials after boiling, and retaining the liquid medicine; step 4, continuously boiling the liquid medicine to evaporate water, concentrating to one third of the total volume, and extinguishing the fire to cool the liquid medicine; 5, adding the medicine powder in the step 2 and the B-type auxiliary mixture into the cooled medicine liquid, and stirring; and 6, baking the stirred mixed ointment at low temperature to remove moisture, and crushing into powder to obtain the composition.
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Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, in particular to an antiarrhythmic Chinese medicine composition. Background Art

[0002] Arrhythmia is caused by abnormal excitation of the sinus node or excitation generated outside the sinus node, slow conduction, blockage or conduction through abnormal channels, that is, the origin and (or) conduction disorder of cardiac activity leads to abnormal frequency and (or) rhythm of heart beats. Arrhythmia is an important group of cardiovascular diseases. It can occur alone or with other cardiovascular diseases. Its prognosis is related to the cause, inducement, evolution trend of arrhythmia, and whether it leads to severe hemodynamic disorders. It can occur suddenly and cause sudden death, or it can continue to affect the heart and cause its failure.

[0003] For drugs for treating arrhythmias, according to their main action channels and electrophysiological characteristics, many drugs with different chemical structures are classified into four categories: Class I: sodium channel blockers; Class II: β-adrenergic receptor antagonists; Class III: drugs that prolong action potential duration (potassium ion channel blockers); Class IV: calcium channel blockers. The main drugs for treating arrhythmias in clinical practice include quinidine, lidocaine, cetirizine, amiodarone, verapamil, etc., which have certain therapeutic effects, but also show obvious adverse reactions and toxic side effects. In addition to chemical drugs, some traditional Chinese medicines have also been invented.

[0004] For example, the disclosure of an antiarrhythmic Chinese medicine composition and its application with publication number CN 115068551 A, the antiarrhythmic Chinese medicine composition can prolong the action potential interval of myocardial cells, thereby prolonging the refractory period of myocardial electrical activity. This mechanism of action has the effect of inhibiting arrhythmias induced by excitation reentry, has no toxic side effects, and provides a new drug for the clinical treatment of ventricular, atrial or supraventricular arrhythmias and other diseases, and has good application prospects.

[0005] However, this technical solution only has an inhibitory effect on arrhythmia and is an emergency medication. It cannot regulate the patient's body and treat arrhythmia from the source. At the same time, although the traditional Chinese medicines in the comparison documents can cure arrhythmia, they are all main medicines, and there are conflicts in their medicinal properties, which does not conform to the concept of monarch, minister, assistant and envoy in traditional Chinese medicine. Not only is it difficult to exert the efficacy of the medicine, but the lotus seed core, coptis chinensis and sophora flavescens are all relatively cold herbs, while ginseng is a very hot herb. The conflict between the two herbs will cause harm to the patient's body. Summary of the invention

[0006] 1. Technical issues to be resolved

[0007] In view of the deficiencies in the prior art, the present invention provides an antiarrhythmic Chinese medicine composition, which has the advantages of not only being able to be used for short-term emergency treatment of arrhythmias but also being able to be taken for a long time to regulate the body, and having a mild medicinal property and no medicinal conflict with the human body, thereby solving the problems of the above-mentioned technologies.

[0008] (II) Technical solution

[0009] To achieve the above object, the present invention provides the following technical solution: an antiarrhythmic Chinese medicine composition, the composition is in powder form, and is yellow-brown after being brewed with water. The composition comprises a Class A Chinese herbal medicine extract and a Class B auxiliary mixture, and the Class A Chinese herbal medicine extract comprises the following materials in weight ratio:

[0010]

[0011] The Class B auxiliary mixture includes the following materials in weight ratio:

[0012]

[0013] Preferably, the C-type trace elements include raw materials in the following weight ratios:

[0014]

[0015]

[0016] Through the above technical scheme, magnesium helps maintain a normal heart rhythm. Magnesium regulates the contraction and relaxation of heart muscles, which helps maintain the normal rhythm of the heart. In addition, magnesium promotes vasodilation and improves the blood supply to the heart, thereby reducing the burden on the heart and helping to prevent arrhythmia. Potassium helps maintain a normal heart rhythm. Potassium regulates the contraction and relaxation of heart muscles, which helps maintain the normal rhythm of the heart. In addition, potassium promotes the excretion of sodium and maintains electrolyte balance, thereby helping to prevent arrhythmia. Zinc promotes the growth and repair of heart muscles, which helps maintain the normal function of the heart. In addition, zinc promotes the function of the immune system, which helps prevent heart disease and arrhythmia. Selenium promotes the growth and repair of heart muscles, which helps maintain the normal function of the heart. In addition, selenium is also antioxidant, reduces damage by free radicals, and helps prevent heart disease and arrhythmia.

[0017] Preferably, the method for preparing the Class C trace elements comprises the following steps:

[0018] S1.1. Place magnesium, potassium, zinc and selenium separately according to their respective proportions, and clean and disinfect the required containers;

[0019] S1.2. Put magnesium, potassium, zinc and selenium into containers respectively and add distilled water which is ten times the total amount of the magnesium, potassium, zinc and selenium into the containers respectively and mix them;

[0020] S1.3, heat the distilled water to 30°C-45°C, and use a stirring device to fully mix the magnesium, potassium, zinc and selenium with the distilled water added to their respective containers;

[0021] S1.4. Continue to raise the temperature to 70℃-90℃ and concentrate the solution to 1 / 3 of the original level, then mix the magnesium solution, potassium solution, zinc solution and selenium solution in sequence;

[0022] S1.5, the mixed solution is continued to be concentrated at high temperature until the total weight is 50%, and then the concentration is stopped and cooled naturally;

[0023] S1.6. Add 50% of the total weight of alcohol to the concentrated mixture, mix well and seal for storage.

[0024] Through the above technical scheme, magnesium, potassium, zinc and selenium are mixed into one C-type trace elements by using a mixing, purification, drying and powdering method, thereby assisting the composition in treating arrhythmia.

[0025] Preferably, the method for preparing the type B auxiliary mixture comprises the following steps:

[0026] S2.1. Wash and dry the Cyperus rotundus and put it into the distiller, and place the Panax notoginseng powder at the outlet of the distiller.

[0027] S2.2, start the distiller to distill the Cyperus rotundus at high temperature to obtain an extract, and mix the extract in liquid form with the notoginseng powder to form a paste;

[0028] S2.3. After the paste is cooled naturally, add lidocaine and continue to stir and mix until it is uniform;

[0029] S2.4, pour the C-type trace elements into the paste and stir at a stirring rate of 60 / prm for 30 min;

[0030] S2.5. The mixture after successful stirring is sent into a container and heated in water to evaporate the alcohol in the mixture;

[0031] S2.6. After the alcohol in the mixture has evaporated, it is sent to a freeze dryer and freeze-dried into powder to obtain a Class B auxiliary mixture.

[0032] Through the above technical scheme, the cyperus contains a variety of active ingredients, such as volatile oils, alkaloids and flavonoids, etc. These ingredients play an important role in the treatment of arrhythmia. At the same time, the cyperus has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply of the heart and promote the repair and growth of cardiac muscle. In addition, the cyperus also has the effect of relaxing muscles and activating collaterals, which can regulate the rhythm of the heart and reduce the occurrence of arrhythmia. Further, the Panax notoginseng contains a variety of active ingredients, such as Panax notoginseng saponins, Panax notoginseng glycosides and Panax notoginseng alcohol, etc. These ingredients play an important role in the treatment of arrhythmia. Panax notoginseng has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply of the heart and promote the repair and growth of cardiac muscle. In addition, Panax notoginseng also has anticoagulant and antioxidant effects, which can reduce thrombosis and free radical damage, and help prevent heart disease and arrhythmia. Further, lidocaine is a sodium channel blocker that can inhibit the excitability and conductivity of cardiac muscle cells. Lidocaine blocks the sodium channels on cardiac muscle cells and reduces the influx of sodium ions, thereby inhibiting the potential rise and conduction speed of cardiac muscle cells, reducing abnormal potential conduction and the occurrence of arrhythmias. In addition, lidocaine can also reduce the automaticity of cardiac muscle cells, inhibit abnormal autonomy, and help restore normal heart rate and rhythm. Among them, tanshinone, the active ingredient in salvia miltiorrhiza, has the effect of promoting blood circulation and removing blood stasis, which can promote blood circulation and improve blood supply to the heart. The blood-activating and blood-dispelling effect of salvia miltiorrhiza can improve blood supply to the heart. The active ingredients in Panax notoginseng powder, such as notoginsenosides, notoginsenosides and notoginseng alcohol, can promote blood circulation and improve blood supply to the heart. Blood-replenishing and blood-activating can promote the repair and growth of heart muscles, improve heart function, and thus reduce the occurrence of arrhythmias. Cyperus rotundus, the active ingredient cyperus rotundus, can regulate the rhythm of the heart and balance the excitability and conductivity of the heart. The three assist each other and provide stable and gentle treatment for patients with arrhythmia.

[0033] Preferably, the water-insulated heating temperature of ten kilograms of the mixture in S2.5 is 60°C-75°C, and the water-insulated heating time is 15min-20min, and the time is increased by 10% for every additional five kilograms.

[0034] Through the above technical solution, passed.

[0035] Preferably, a stirrer is also used when heating the mixture in water bath in S2.5, and the stirring time of the stirrer is 3 min-5 min, the stirring rate is 20 / prm-40 / prm, and the freeze-drying time of the freeze dryer is 24 h.

[0036] An antiarrhythmic Chinese medicine composition comprises the following preparation steps:

[0037] Step 1, prepare Class A Chinese herbal medicine extract materials: prepare Salvia miltiorrhiza, honeysuckle, Uncaria rhynchophylla, Poria cocos, Ophiopogon japonicus and Gastrodia elata respectively according to weight ratio;

[0038] Step 2: crush the salvia miltiorrhiza, Poria cocos, Ophiopogon japonicus and Gastrodia elata in step 1 into powder, wherein the powder particles have a diameter of 15-20 microns, and mix them evenly;

[0039] Step 3: Put honeysuckle and Uncaria rhynchophylla into the boiler and boil them, with the ratio of medicine liquid being 1:50. After boiling, filter the herbs and keep the medicine liquid;

[0040] Step 4: Continue to boil the medicine to evaporate the water and concentrate it to one third of the total volume, then turn off the fire and cool the medicine;

[0041] Step 5: Add the cooled liquid medicine into the powder and the auxiliary mixture of type B in step 2 and stir;

[0042] Step 6: After stirring, the mixed ointment is baked at low temperature to remove moisture and crushed into powder to obtain a composition.

[0043] Preferably, in step three, the boiling temperature of honeysuckle and Uncaria rhynchophylla is 100° C.-110° C., the boiling time is 3 h-5 h, and the filter diameter is 300 μm-500 μm when filtering the medicinal materials.

[0044] Preferably, in step 4, the temperature for boiling and evaporating the water of the medicinal solution is 100° C., and the time for cooling the concentrated medicinal solution after turning off the fire is 24h-32h.

[0045] Preferably, the B-type auxiliary mixture accounts for 4.5%-17%.

[0046] Compared with the prior art, the present invention provides an antiarrhythmic Chinese medicine composition having the following

[0047] Beneficial effects:

[0048] 1. The present invention uses lidocaine to block the sodium channels on cardiac muscle cells and reduce the influx of sodium ions, thereby inhibiting the potential rise and conduction speed of cardiac muscle cells, reducing abnormal potential conduction and the occurrence of arrhythmia. The blood circulation and stasis-removing effect of salvia miltiorrhiza can improve the blood supply to the heart. The active ingredients in notoginseng powder, such as notoginseng saponins, notoginseng glycosides and notoginseng alcohol, can promote blood circulation, achieving the beneficial effect of not only being used for short-term emergency treatment of arrhythmia but also being used for long-term conditioning of the body.

[0049] 2. The present invention contains a variety of active ingredients in the B-type auxiliary mixing of the cyperus rotundus, such as volatile oil, alkaloids and flavonoids, etc. These ingredients play an important role in the treatment of arrhythmia, and the cyperus rotundus has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply of the heart and promote the repair and growth of cardiac muscle. In addition, the cyperus rotundus also has the effect of relaxing muscles and tendons, which can regulate the rhythm of the heart and reduce the occurrence of arrhythmia. Further, the notoginseng contains a variety of active ingredients, such as notoginseng saponins, notoginseng glycosides and notoginseng alcohol, etc. These ingredients play an important role in the treatment of arrhythmia, and the notoginseng has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply of the heart and promote the repair and growth of cardiac muscle. In addition, the notoginseng also has the effect of anticoagulation and anti-oxidation, which can reduce thrombosis and free radical damage, and is helpful to prevent heart disease and arrhythmia, and reaches the beneficial effect that the composition has mild medicinal properties and will not have medicinal properties conflicts with the human body.

[0050] 3. The present invention can improve the blood supply to the heart through the blood-activating and blood-stasis-removing effects of Salvia miltiorrhiza. The active ingredients in Panax notoginseng powder, such as notoginsenosides, notoginsenosides and notoginseng alcohol, can promote blood circulation and improve the blood supply to the heart. Blood-tonifying and blood-activating can promote the repair and growth of heart muscles and improve heart function, thereby reducing the occurrence of arrhythmia. The active ingredient in Cyperus rotundus, cyperone, can regulate the rhythm of the heart and balance the excitability and conductivity of the heart. The three ingredients assist each other and provide stable and gentle treatment for patients with arrhythmia, thereby achieving the beneficial effect of mutual assistance between the medicinal materials to enhance the efficacy of the medicines. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] Figure 1 It is a schematic diagram of the process of the present invention. DETAILED DESCRIPTION

[0052] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0053] See also Figure 1 , an antiarrhythmic Chinese medicine composition, the composition is in powder form, and is yellow-brown after being brewed with water. The composition comprises a Class A Chinese herbal medicine extract and a Class B auxiliary mixture, and the Class A Chinese herbal medicine extract comprises the following materials in weight ratio:

[0054]

[0055] Class B auxiliary mixtures include the following materials in weight ratio:

[0056]

[0057] Specifically, the Class C trace elements include the following raw materials in weight ratio:

[0058]

[0059]

[0060] The advantages are that magnesium helps maintain a normal heart rhythm. Magnesium regulates the contraction and relaxation of heart muscles, helping to maintain a normal heart rhythm. In addition, magnesium promotes vasodilation and improves blood supply to the heart, thereby reducing the burden on the heart and helping to prevent arrhythmias. Potassium helps maintain a normal heart rhythm. Potassium regulates the contraction and relaxation of heart muscles, helping to maintain a normal heart rhythm. In addition, potassium promotes the excretion of sodium and maintains electrolyte balance, thereby helping to prevent arrhythmias. Zinc promotes the growth and repair of heart muscles, helping to maintain normal heart function. In addition, zinc promotes the function of the immune system, helping to prevent heart disease and arrhythmias. Selenium promotes the growth and repair of heart muscles, helping to maintain normal heart function. In addition, selenium is also an antioxidant, reducing damage from free radicals, helping to prevent heart disease and arrhythmias.

[0061] Specifically, the method for preparing Class C trace elements comprises the following steps:

[0062] S1.1. Place magnesium, potassium, zinc and selenium separately according to their respective proportions, and clean and disinfect the required containers;

[0063] S1.2. Put magnesium, potassium, zinc and selenium into containers respectively and add distilled water which is ten times the total amount of the magnesium, potassium, zinc and selenium into the containers respectively and mix them;

[0064] S1.3, heat the distilled water to 30°C-45°C, and use a stirring device to fully mix the magnesium, potassium, zinc and selenium with the distilled water added to their respective containers;

[0065] S1.4. Continue to raise the temperature to 70℃-90℃ and concentrate the solution to 1 / 3 of the original level, then mix the magnesium solution, potassium solution, zinc solution and selenium solution in sequence;

[0066] S1.5, the mixed solution is continued to be concentrated at high temperature until the total weight is 50%, and then the concentration is stopped and cooled naturally;

[0067] S1.6. Add 50% of the total weight of alcohol to the concentrated mixture, mix well and seal for storage.

[0068] The invention has the advantage that magnesium, potassium, zinc and selenium are mixed into one as C-type trace elements by using a mixing, purification, drying and powdering method, thereby assisting the composition in treating arrhythmia.

[0069] Specifically, the method for preparing the type B auxiliary mixture comprises the following steps:

[0070] S2.1. Wash and dry the Cyperus rotundus and put it into the distiller, and place the Panax notoginseng powder at the outlet of the distiller.

[0071] S2.2, start the distiller to distill the Cyperus rotundus at high temperature to obtain an extract, and mix the extract in liquid form with the notoginseng powder to form a paste;

[0072] S2.3. After the paste is cooled naturally, add lidocaine and continue to stir and mix until it is uniform;

[0073] S2.4, pour the C-type trace elements into the paste and stir at a stirring rate of 60 / prm for 30 min;

[0074] S2.5. The mixture after successful stirring is sent into a container and heated in water to evaporate the alcohol in the mixture;

[0075] S2.6. After the alcohol in the mixture has evaporated, it is sent to a freeze dryer and freeze-dried into powder to obtain a Class B auxiliary mixture.

[0076] The advantage is that Cyperus contains a variety of active ingredients, such as volatile oils, alkaloids and flavonoids, which play an important role in the treatment of arrhythmia. At the same time, Cyperus has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply to the heart and promote the repair and growth of heart muscle. In addition, Cyperus also has the effect of relaxing muscles and activating collaterals, which can regulate the rhythm of the heart and reduce the occurrence of arrhythmia. Further, Panax notoginseng contains a variety of active ingredients, such as Panax notoginseng saponins, Panax notoginseng glycosides and Panax notoginseng alcohol, which play an important role in the treatment of arrhythmia. Panax notoginseng has the effect of promoting blood circulation and removing blood stasis, which can improve the blood supply to the heart and promote the repair and growth of heart muscle. In addition, Panax notoginseng also has anticoagulant and antioxidant effects, which can reduce thrombosis and free radical damage, and help prevent heart disease and arrhythmia. Further, lidocaine is a sodium channel blocker that can inhibit the excitability and conductivity of cardiac muscle cells. Lidocaine blocks the sodium channels on cardiac muscle cells and reduces the influx of sodium ions, thereby inhibiting the potential rise and conduction speed of cardiac muscle cells, reducing abnormal potential conduction and the occurrence of arrhythmias. In addition, lidocaine can also reduce the automaticity of cardiac muscle cells, inhibit abnormal autonomy, and help restore normal heart rate and rhythm. Among them, tanshinone, the active ingredient in salvia miltiorrhiza, has the effect of promoting blood circulation and removing blood stasis, which can promote blood circulation and improve blood supply to the heart. The blood-activating and blood-dispelling effect of salvia miltiorrhiza can improve blood supply to the heart. The active ingredients in Panax notoginseng powder, such as notoginsenosides, notoginsenosides and notoginseng alcohol, can promote blood circulation and improve blood supply to the heart. Blood-replenishing and blood-activating can promote the repair and growth of heart muscles, improve heart function, and thus reduce the occurrence of arrhythmias. Cyperus rotundus, the active ingredient cyperus rotundus, can regulate the rhythm of the heart and balance the excitability and conductivity of the heart. The three assist each other and provide stable and gentle treatment for patients with arrhythmia.

[0077] Specifically, the water-insulated heating temperature of less than ten kilograms of the mixture in S2.5 is 60°C-75°C, and the water-insulated heating time is 15min-20min. For every additional five kilograms, the time is increased by 10%.

[0078] The advantage is that it passes.

[0079] Specifically, a stirrer is used when heating the mixture in water bath in S2.5, and the stirring time of the stirrer is 3 min-5 min, the stirring rate is 20 / prm-40 / prm, and the freeze drying time of the freeze dryer is 24 h.

[0080] An antiarrhythmic Chinese medicine composition comprises the following preparation steps:

[0081] Step 1, prepare Class A Chinese herbal medicine extract materials: prepare Salvia miltiorrhiza, honeysuckle, Uncaria rhynchophylla, Poria cocos, Ophiopogon japonicus and Gastrodia elata respectively according to weight ratio;

[0082] Step 2: crush the salvia miltiorrhiza, Poria cocos, Ophiopogon japonicus and Gastrodia elata in step 1 into powder, wherein the powder particles have a diameter of 15-20 microns, and mix them evenly;

[0083] Step 3: Put honeysuckle and Uncaria rhynchophylla into the boiler and boil them, with the ratio of medicine liquid being 1:50. After boiling, filter the herbs and keep the medicine liquid;

[0084] Step 4: Continue to boil the medicine to evaporate the water and concentrate it to one third of the total volume, then turn off the fire and cool the medicine;

[0085] Step 5: Add the cooled liquid medicine into the powder and the auxiliary mixture of type B in step 2 and stir;

[0086] Step 6: After stirring, the mixed ointment is baked at low temperature to remove moisture and crushed into powder to obtain a composition.

[0087] Specifically, in step three, the boiling temperature of honeysuckle and Uncaria rhynchophylla is 100° C.-110° C., the boiling time is 3 h-5 h, and the filter diameter is 300 μm-500 μm when filtering the medicinal materials.

[0088] Specifically, in step 4, the temperature for boiling and evaporating the water of the medicinal solution is 100° C., and the time for cooling the concentrated medicinal solution after turning off the fire is 24h-32h.

[0089] Specifically, the Class B auxiliary mixture accounts for 4.5%-17%.

[0090] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An antiarrhythmic Chinese medicine composition, characterized in that: The composition is in powder form and is yellow-brown after being brewed with water. The composition comprises a Class A Chinese herbal medicine extract and a Class B auxiliary mixture. The Class A Chinese herbal medicine extract comprises the following materials in weight ratio: The Class B auxiliary mixture includes the following materials in weight ratio:

2. An antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: The Class C trace elements include the following raw materials in weight ratio:

3. An antiarrhythmic Chinese medicine composition according to claim 2, characterized in that: The method for preparing the Class C trace elements comprises the following steps: S1.

1. Place magnesium, potassium, zinc and selenium separately according to their respective proportions, and clean and disinfect the required containers; S1.

2. Put magnesium, potassium, zinc and selenium into containers respectively and add distilled water which is ten times the total amount of the magnesium, potassium, zinc and selenium into the containers respectively and mix them; S1.3, heat the distilled water to 30°C-45°C, and use a stirring device to fully mix the magnesium, potassium, zinc and selenium with the distilled water added to their respective containers; S1.

4. Continue to raise the temperature to 70℃-90℃ and concentrate the solution to 1 / 3 of the original level, then mix the magnesium solution, potassium solution, zinc solution and selenium solution in sequence; S1.5, the mixed solution is continued to be concentrated at high temperature until the total weight is 50%, and then the concentration is stopped and cooled naturally; S1.

6. Add 50% of the total weight of alcohol to the concentrated mixture, mix well and seal for storage.

4. The antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: The method for preparing the type B auxiliary mixture comprises the following steps: S2.

1. Wash and dry the Cyperus rotundus and put it into the distiller, and place the Panax notoginseng powder at the outlet of the distiller. S2.2, start the distiller to distill the Cyperus rotundus at high temperature to obtain an extract, and mix the extract in liquid form with the notoginseng powder to form a paste; S2.

3. After the paste is cooled naturally, add lidocaine and continue to stir and mix until it is uniform; S2.4, pour the C-type trace elements into the paste and stir at a stirring rate of 60 / prm for 30 min; S2.

5. The mixture after successful stirring is sent into a container and heated in water to evaporate the alcohol in the mixture; S2.

6. After the alcohol in the mixture has evaporated, it is sent to a freeze dryer and freeze-dried into powder to obtain a Class B auxiliary mixture.

5. An antiarrhythmic Chinese medicine composition according to claim 4, characterized in that: In the S2.5, the water-insulated heating temperature within ten kilograms of the mixture is 60°C-75°C, and the water-insulated heating time is 15min-20min. For every additional five kilograms, the time is increased by 10%.

6. The antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: In the S2.5, a stirrer is also used when heating the mixture in water, and the stirring time of the stirrer is 3 min-5 min, the stirring rate is 20 / prm-40 / prm, and the freeze-drying time of the freeze dryer is 24 h.

7. An antiarrhythmic Chinese medicine composition, characterized in that: The method comprises the following preparation steps: Step 1, prepare Class A Chinese herbal medicine extract materials: prepare Salvia miltiorrhiza, honeysuckle, Uncaria rhynchophylla, Poria cocos, Ophiopogon japonicus and Gastrodia elata respectively according to weight ratio; Step 2: crush the salvia miltiorrhiza, Poria cocos, Ophiopogon japonicus and Gastrodia elata in step 1 into powder, wherein the powder particles have a diameter of 15-20 microns, and mix them evenly; Step 3: Put honeysuckle and Uncaria rhynchophylla into the boiler and boil them, with the ratio of medicine liquid being 1:

50. After boiling, filter the herbs and keep the medicine liquid; Step 4: Continue to boil the medicine to evaporate the water and concentrate it to one third of the total volume, then turn off the fire and cool the medicine; Step 5: Add the cooled liquid medicine into the powder and the auxiliary mixture of type B in step 2 and stir; Step 6: After stirring, the mixed ointment is baked at low temperature to remove moisture, and then crushed into powder to obtain a composition.

8. The antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: In the step 3, the boiling temperature of honeysuckle and Uncaria rhynchophylla is 100° C.-110° C., the boiling time is 3 h-5 h, and the filter diameter is 300 μm-500 μm when filtering the medicinal materials.

9. The antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: In the step 4, the temperature for boiling and evaporating the water of the medicinal solution is 100° C., and the time for cooling the concentrated medicinal solution after the fire is turned off is 24h-32h.

10. The antiarrhythmic Chinese medicine composition according to claim 1, characterized in that: The Class B auxiliary mixture accounts for 4.5%-17%.

Citation Information

Patent Citations

  • Anti-arrhythmia traditional Chinese medicine composition and application thereof

    CN115068551A