Chinese herbal medicine compound powder for reducing diarrhea rate of early weaned piglets and preparation method of Chinese herbal medicine compound powder

Abstract

The invention discloses Chinese herbal medicine compound powder for reducing the diarrhea rate of early weaned piglets and a preparation method of the Chinese herbal medicine compound powder. The Chinese herbal medicine compound powder is prepared from the following raw materials in parts by weight: a core antidiarrheal component: 9-16 parts of pomegranate bark, 6-12 parts of gallnut and 6-12 parts of poria cocos; spleen and stomach strengthening components: 5-10 parts of codonopsis pilosula, 5-10 parts of rhizoma atractylodis macrocephalae, 4-8 parts of poria cocos, 4-9 parts of Chinese yam and 2-5 parts of semen coicis; immunoregulation components: 4-9 parts of baicalin copper and 5-10 parts of astragalus membranaceus; microbial balance components: 12 to 24 parts of montmorillonite and 2 to 5 parts of sophocarpidine; and auxiliary synergistic components: 6-10 parts of hawthorn, 4-8 parts of elecampane and 4-8 parts of acanthopanax. The invention relates to the technical field of veterinary drugs. According to the Chinese herbal medicine compound powder capable of reducing the diarrhea rate of the early weaned piglets and the preparation method thereof, the Chinese herbal medicine compound powder capable of improving the corresponding barrier capability is prepared by researching a physical barrier, a chemical barrier, an immune barrier and a biological barrier of intestinal tracts of the early weaned piglets; therefore, the diarrhea rate of early weaned piglets is reduced more effectively, and a multi-target synergistic mechanism is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of veterinary drugs, in particular to a Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets and a preparation method thereof. Background Art

[0002] Nursery pigs, commonly known as weaned piglets, have the characteristics of rapid growth and development and high susceptibility to diseases, and therefore require careful feeding. The goal of feeding and management is to successfully wean piglets, reduce weaning stress, control diarrhea, and increase the piglet survival rate and growth rate. Current problems include: stress syndrome after weaning, which manifests as diarrhea, food refusal, growth stagnation (even negative growth), stiff pigs, and even death.

[0003] Reference patent publication number "CN107929386A" discloses a Chinese medicine powder for preventing and treating weaning stress diarrhea in piglets, including the following components mixed by weight: Astragalus, Codonopsis, Atractylodes, Poria, Licorice, Portulaca, Shenqu, Crataegus and Angelica are weighed according to the measurement, crushed and mixed with each other, and sieved to obtain the finished product.

[0004] As shown in the above technologies, existing Chinese herbal medicines have made certain progress in nutrition in animal production, but they are more focused on the effects on growth performance and blood indicators. However, there are few studies on the intestinal flora and intestinal physiological structure of early-weaned piglets, but less research on their growth-promoting mechanisms, especially on the regulation of the physical barrier of the small intestinal mucosa of weaned piglets. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets and a preparation method thereof, which solves the problem that the existing Chinese herbal medicines fail to regulate the physical barrier of the small intestinal mucosa of weaned piglets.

[0006] To achieve the above objectives, the present invention is implemented by the following technical scheme: The Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets comprises the following raw materials in parts by weight:

[0007] Core antidiarrheal ingredients: 9-16 parts of pomegranate peel, 6-12 parts of gallnut and 6-12 parts of Poria cocos;

[0008] Ingredients for strengthening the spleen and stomach: 5-10 parts of Codonopsis pilosula, 5-10 parts of Atractylodes macrocephala, 4-8 parts of Poria cocos, 4-9 parts of Dioscorea opposita, and 2-5 parts of Coix seeds;

[0009] Immunomodulatory ingredients: 4-9 parts of copper baicalin and 5-10 parts of astragalus;

[0010] Microbial balance ingredients: 12-24 parts of montmorillonite and 2-5 parts of matrine;

[0011] Auxiliary synergistic ingredients: 6-10 parts of hawthorn, 4-8 parts of costusroot and 4-8 parts of acanthopanax senticosus.

[0012] Preferably, it is made of the following raw materials in parts by weight:

[0013] Core antidiarrheal ingredients: 9 parts of pomegranate peel, 6 parts of gallnut and 6 parts of Poria;

[0014] Ingredients for strengthening the spleen and stomach: 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 4 parts of Dioscorea opposita, and 2 parts of Coix seeds;

[0015] Immunomodulatory ingredients: 4 parts of copper baicalin and 5 parts of astragalus;

[0016] Microbial balance ingredients: 12 parts of montmorillonite and 2 parts of matrine;

[0017] Auxiliary synergistic ingredients: 6 parts of hawthorn, 4 parts of costusroot and 4 parts of acanthopanax senticosus.

[0018] Preferably, it is made from the following raw materials in parts by weight:

[0019] Core antidiarrheal ingredients: 13 parts of pomegranate peel, 9 parts of gallnut and 9 parts of Poria;

[0020] Ingredients for strengthening the spleen and stomach: 8 parts of Codonopsis pilosula, 8 parts of Atractylodes macrocephala, 6 parts of Poria cocos, 7 parts of Dioscorea opposita and 4 parts of Coix seed;

[0021] Immunomodulatory ingredients: 7 parts of copper baicalin and 8 parts of astragalus;

[0022] Microbial balance ingredients: 18 parts of montmorillonite and 4 parts of matrine;

[0023] Auxiliary synergistic ingredients: 8 parts of hawthorn, 6 parts of costusroot and 6 parts of acanthopanax senticosus.

[0024] Preferably, it is made from the following raw materials in parts by weight:

[0025] Core antidiarrheal ingredients: 16 parts of pomegranate peel, 12 parts of gallnut and 12 parts of Poria;

[0026] Ingredients for strengthening the spleen and stomach: 10 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 8 parts of Poria cocos, 9 parts of Dioscorea opposita and 5 parts of Coix seeds;

[0027] Immunomodulatory ingredients: 9 parts of copper baicalin and 10 parts of astragalus;

[0028] Microbial balance ingredients: 24 parts of montmorillonite and 5 parts of matrine;

[0029] Auxiliary synergistic ingredients: 10 parts of hawthorn, 8 parts of costusroot and 8 parts of acanthopanax senticosus.

[0030] Preferably, the baicalin copper, astragalus and yam have the effects of enhancing the expression of occludin and ZO-1 proteins in the intestine and repairing the physical barrier.

[0031] Preferably, the coix seed has the effects of eliminating edema, improving diarrhea, relieving skin abscesses and helping to enhance spleen and stomach functions, and the Acanthopanax senticosus has the effects of enhancing physical strength, improving fatigue and improving immunity.

[0032] The present invention also discloses a method for preparing a Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets, which specifically comprises the following steps:

[0033] Step 1: Raw material pretreatment

[0034] S1: Screening and cleaning of medicinal materials: remove impurities from pomegranate peel, Chinese gallnut, Poria cocos, Codonopsis pilosula, Atractylodes macrocephala, Poria cocos, Dioscorea opposita, Coix seeds, Aucklandia lappa and Acanthopanax senticosus, rinse with pure water for 2-3 times, drain the surface water, and process the pomegranate peel separately;

[0035] S2: Low temperature drying: The washed medicinal materials are placed in a 60°C hot air circulation drying oven for 4-6 hours to make the moisture content ≤8%;

[0036] S3: Crushing and sieving: The dried medicinal materials are crushed by a universal grinder and passed through a 100-mesh sieve (particle size ≤ 150 μm) for later use;

[0037] Step 2: Directed extraction of active ingredients

[0038] S1: Stir-frying pomegranate peel into charcoal: Place the pomegranate peel in a stir-frying machine and stir-fry at 180°C for 10 minutes until the surface is burnt black and the tannic acid content is reduced from 12.3% to 6.8%. Then, crush and pass through an 80-mesh sieve;

[0039] S2: Extraction of copper baicalin: Scutellaria crude powder was mixed with 60% ethanol at a solid-liquid ratio of 1:10, and refluxed at 80°C for 2 hours. After filtration, it was concentrated under reduced pressure to an extract with a relative density of 1.2, and spray-dried to obtain the copper baicalin extract;

[0040] S3: Matrine extraction: Sophora flavescens root powder was extracted with 70% ethanol by ultrasound, and the extract was purified by macroporous resin and freeze-dried for later use;

[0041] Step 3: Preparation of excipients

[0042] Montmorillonite ultrafine grinding: Montmorillonite is processed by air jet mill to a particle size of ≤50μm to enhance the toxin adsorption capacity;

[0043] Step 4: Mixing and stabilization

[0044] S1: Three-dimensional mixing process: put the extract powder, modified medicinal materials, montmorillonite and oligofructose into the three-dimensional motion mixer in proportion, mix at a speed of 25r / min for 30 minutes, and the uniformity CV ≤ 5%;

[0045] S2: Radiation sterilization: The mixed powder is sterilized by cobalt 60 irradiation (dose 8 kGy) to make the total number of microorganisms ≤1000 CFU / g and the moisture content ≤5%;

[0046] Step 5: The finished product is packed into aluminum foil bags by an automatic packaging machine, 500g per bag, and stored in a cool and dry place, sealed and away from light.

[0047] Preferably, the oligofructose added in step 4 accounts for 1-3% of the total amount of the medicine.

[0048] Beneficial Effects

[0049] The present invention provides a Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets and a preparation method thereof. Compared with the prior art, it has the following beneficial effects:

[0050] 1. The Chinese herbal compound powder for reducing the diarrhea rate of early-weaned piglets and its preparation method, through the study of the physical barrier, chemical barrier, immune barrier and biological barrier of the intestine of early-weaned piglets, is prepared with a Chinese herbal compound powder with the ability to improve the corresponding barrier, thereby more effectively reducing the diarrhea rate of early-weaned piglets, multi-target synergistic mechanism, for the first time integrating quadruple intestinal barrier regulation pathways, breaking through the limitation of a single efficacy, and greatly improving the ability of piglets to grow healthily after weaning.

[0051] 2. The Chinese herbal compound powder for reducing the diarrhea rate of early weaned piglets and its preparation method improve the digestive capacity of the piglet's spleen and stomach by adding Codonopsis pilosula, Atractylodes macrocephala, Poria cocos, Chinese yam and Coix seed to the formula of the Chinese herbal compound powder, and cooperate with auxiliary synergistic ingredients to improve the drug's repair and antidiarrhea capabilities.

[0052] 3. The Chinese herbal compound powder for reducing the diarrhea rate of early weaned piglets and its preparation method, by charring the pomegranate peel during the manufacturing process of the Chinese herbal compound powder, thereby reducing the irritation of the drug, making it mild in nature and better suitable for the piglet's stomach. In addition, oligofructose is also added during the mixing process, which is an important ingredient and can promote the proliferation of probiotics in the piglet's stomach. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 The present invention is a flow chart for preparing the Chinese herbal medicine composite powder. DETAILED DESCRIPTION

[0054] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0055] The Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets provides three proportions:

[0056] The invention is made of the following raw materials in parts by weight:

[0057] Core antidiarrheal ingredients: 9-16 parts of pomegranate peel, 6-12 parts of gallnut and 6-12 parts of Poria cocos;

[0058] Ingredients for strengthening the spleen and stomach: 5-10 parts of Codonopsis pilosula, 5-10 parts of Atractylodes macrocephala, 4-8 parts of Poria cocos, 4-9 parts of Dioscorea opposita, and 2-5 parts of Coix seeds;

[0059] Immunomodulatory ingredients: 4-9 parts of copper baicalin and 5-10 parts of astragalus;

[0060] Microbial balance ingredients: 12-24 parts of montmorillonite and 2-5 parts of matrine;

[0061] Auxiliary synergistic ingredients: 6-10 parts of hawthorn, 4-8 parts of costusroot and 4-8 parts of acanthopanax senticosus.

[0062] Baicalin copper, astragalus and yam have the effects of enhancing the expression of occludin and ZO-1 proteins in the intestine and repairing the physical barrier. Coix seed has the effects of eliminating edema, improving diarrhea, relieving skin abscesses and helping to strengthen the spleen and stomach function. Acanthopanax has the effects of enhancing physical strength, improving fatigue and improving immunity.

[0063] Through the study of the physical barrier, chemical barrier, immune barrier and biological barrier of the intestine of early-weaned piglets, a Chinese herbal compound powder with the ability to improve the corresponding barrier capacity is developed, thereby more effectively reducing the diarrhea rate of early-weaned piglets. The multi-target synergistic mechanism integrates the quadruple intestinal barrier regulation pathway for the first time, breaking through the limitation of a single efficacy and greatly improving the ability of piglets to grow healthily after weaning. By adding Codonopsis pilosula, Atractylodes macrocephala, Poria cocos, Chinese yam and Coix seed to the formula of the Chinese herbal compound powder, the digestive capacity of the piglet's spleen and stomach is improved, and the auxiliary synergistic ingredients are used to improve the drug's repair and antidiarrhea capabilities.

[0064] Ratio 1:

[0065] Core antidiarrheal ingredients: 9 parts of pomegranate peel, 6 parts of gallnut and 6 parts of Poria;

[0066] Ingredients for strengthening the spleen and stomach: 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 4 parts of Dioscorea opposita, and 2 parts of Coix seeds;

[0067] Immunomodulatory ingredients: 4 parts of copper baicalin and 5 parts of astragalus;

[0068] Microbial balance ingredients: 12 parts of montmorillonite and 2 parts of matrine;

[0069] Auxiliary synergistic ingredients: 6 parts of hawthorn, 4 parts of costusroot and 4 parts of acanthopanax senticosus.

[0070] Ratio 2:

[0071] The invention is made of the following raw materials in parts by weight:

[0072] Core antidiarrheal ingredients: 13 parts of pomegranate peel, 9 parts of gallnut and 9 parts of Poria;

[0073] Ingredients for strengthening the spleen and stomach: 8 parts of Codonopsis pilosula, 8 parts of Atractylodes macrocephala, 6 parts of Poria cocos, 7 parts of Dioscorea opposita and 4 parts of Coix seed;

[0074] Immunomodulatory ingredients: 7 parts of copper baicalin and 8 parts of astragalus;

[0075] Microbial balance ingredients: 18 parts of montmorillonite and 4 parts of matrine;

[0076] Auxiliary synergistic ingredients: 8 parts of hawthorn, 6 parts of costusroot and 6 parts of acanthopanax senticosus.

[0077] Ratio three:

[0078] The invention is made of the following raw materials in parts by weight:

[0079] Core antidiarrheal ingredients: 16 parts of pomegranate peel, 12 parts of gallnut and 12 parts of Poria;

[0080] Ingredients for strengthening the spleen and stomach: 10 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 8 parts of Poria cocos, 9 parts of Dioscorea opposita and 5 parts of Coix seeds;

[0081] Immunomodulatory ingredients: 9 parts of copper baicalin and 10 parts of astragalus;

[0082] Microbial balance ingredients: 24 parts of montmorillonite and 5 parts of matrine;

[0083] Auxiliary synergistic ingredients: 10 parts of hawthorn, 8 parts of costusroot and 8 parts of acanthopanax senticosus.

[0084] The present invention also discloses a Chinese herbal medicine composite powder for reducing the diarrhea rate of early weaned piglets and a preparation method thereof, which comprises the following steps:

[0085] Step 1: Raw material pretreatment

[0086] S1: screening and cleaning of medicinal materials: remove impurities from 9 parts of pomegranate peel, 6 parts of Chinese gallnut, 6 parts of Poria cocos, 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 4 parts of Dioscorea opposita, 2 parts of Coix seeds, 6 parts of Aucklandia lappa and 4 parts of Acanthopanax pentaphyllum, rinse with pure water for 2-3 times, drain the surface water, and process the pomegranate peel separately;

[0087] S2: Low temperature drying: The washed medicinal materials are placed in a 60°C hot air circulation drying oven for 4-6 hours to make the moisture content ≤8%;

[0088] S3: Crushing and sieving: The dried medicinal materials are crushed by a universal grinder and passed through a 100-mesh sieve (particle size ≤ 150 μm) for later use;

[0089] Step 2: Directed extraction of active ingredients

[0090] S1: Stir-frying pomegranate peel into charcoal: Place the pomegranate peel in a stir-frying machine and stir-fry at 180°C for 10 minutes until the surface is burnt black and the tannic acid content is reduced from 12.3% to 6.8%. Then, crush and pass through an 80-mesh sieve;

[0091] S2: Extraction of copper baicalin: Scutellaria crude powder was mixed with 60% ethanol at a solid-liquid ratio of 1:10, and refluxed at 80°C for 2 hours. After filtration, it was concentrated under reduced pressure to an extract with a relative density of 1.2, and spray-dried to obtain the copper baicalin extract;

[0092] S3: Matrine extraction: Sophora flavescens root powder was extracted with 70% ethanol by ultrasound, and the extract was purified by macroporous resin and freeze-dried for later use;

[0093] Step 3: Preparation of excipients

[0094] Montmorillonite ultrafine grinding: Montmorillonite is processed by air jet mill to a particle size of ≤50μm to enhance the toxin adsorption capacity;

[0095] Step 4: Mixing and stabilization

[0096] S1: Three-dimensional mixing process: Put the extract powder, modified medicinal materials, montmorillonite and oligofructose into the three-dimensional motion mixer in proportion, with oligofructose accounting for 1-3% of the total amount of the medicine, and mix at a speed of 25r / min for 30 minutes, with a uniformity CV ≤ 5%;

[0097] S2: Radiation sterilization: The mixed powder is sterilized by cobalt 60 irradiation (dose 8 kGy) to make the total number of microorganisms ≤1000 CFU / g and the moisture content ≤5%;

[0098] Step 5: The finished product is packed into aluminum foil bags by an automatic packaging machine, 500g per bag, and stored in a cool and dry place, sealed and away from light.

[0099] By charring the pomegranate peel during the manufacturing process of the Chinese herbal compound powder, the irritation of the drug is reduced, making it milder and more suitable for the stomach and intestines of piglets. In addition, adding oligofructose during the mixing process is also an important ingredient that can promote the proliferation of probiotics in the stomach and intestines of piglets.

[0100] Experimental design: Mix the formula 1, formula 2 and formula 3 with the basic feed at a ratio of 1:9 and feed them to four groups of early weaned piglets. Each group has 20 early weaned piglets. A control group was designed. The control group was only fed with the basic feed. After four days of feeding, the physical barrier, chemical barrier, immune barrier, biological barrier and diarrhea rate of the piglets were tested.

[0101] Physical barrier: jejunal villus height, occludin and ZO-1 protein expression;

[0102] Chemical barriers: goblet cell density, Muc-2 secretion;

[0103] Immune barrier: expression of IL-10 and SlgA, pro-inflammatory factors IL-2 and IFN-γ;

[0104] Microbial barrier: Shannon index of intestinal flora, abundance of pathogenic Escherichia coli;

[0105] Diarrhea rate: the proportion of diarrhea in early weaned piglets in a single group experiment.

[0106] Experimental results table:

[0107]

[0108] It can be obtained from the experimental data that, compared with the control group fed with the basic feed, the physical barrier, chemical barrier, immune barrier and biological barrier of early weaned piglets in Example 1, Example 2 and Example 3 were significantly improved, and the diarrhea rate was significantly reduced. Among them, the ratio of various medicinal materials in Example 2 performed best.

[0109] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0110] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal compound powder for reducing diarrhea rate in early weaned piglets, characterized by: The invention is made of the following raw materials in parts by weight: Core antidiarrheal ingredients: 9-16 parts of pomegranate peel, 6-12 parts of gallnut and 6-12 parts of Poria cocos; Ingredients for strengthening the spleen and stomach: 5-10 parts of Codonopsis pilosula, 5-10 parts of Atractylodes macrocephala, 4-8 parts of Poria cocos, 4-9 parts of Dioscorea opposita, and 2-5 parts of Coix seeds; Immunomodulatory ingredients: 4-9 parts of copper baicalin and 5-10 parts of astragalus; Microbial balance ingredients: 12-24 parts of montmorillonite and 2-5 parts of matrine; Auxiliary synergistic ingredients: 6-10 parts of hawthorn, 4-8 parts of costusroot and 4-8 parts of acanthopanax senticosus.

2. The Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: Core antidiarrheal ingredients: 9 parts of pomegranate peel, 6 parts of gallnut and 6 parts of Poria; Ingredients for strengthening the spleen and stomach: 5 parts of Codonopsis pilosula, 5 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 4 parts of Dioscorea opposita, and 2 parts of Coix seeds; Immunomodulatory ingredients: 4 parts of copper baicalin and 5 parts of astragalus; Microbial balance ingredients: 12 parts of montmorillonite and 2 parts of matrine; Auxiliary synergistic ingredients: 6 parts of hawthorn, 4 parts of costusroot and 4 parts of Acanthopanax senticosus.

3. The Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: Core antidiarrheal ingredients: 13 parts of pomegranate peel, 9 parts of gallnut and 9 parts of Poria; Ingredients for strengthening the spleen and stomach: 8 parts of Codonopsis pilosula, 8 parts of Atractylodes macrocephala, 6 parts of Poria cocos, 7 parts of Dioscorea opposita and 4 parts of Coix seed; Immunomodulatory ingredients: 7 parts of copper baicalin and 8 parts of astragalus; Microbial balance ingredients: 18 parts of montmorillonite and 4 parts of matrine; Auxiliary synergistic ingredients: 8 parts of hawthorn, 6 parts of costusroot and 6 parts of acanthopanax senticosus.

4. The Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: Core antidiarrheal ingredients: 16 parts of pomegranate peel, 12 parts of gallnut and 12 parts of Poria; Ingredients for strengthening the spleen and stomach: 10 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 8 parts of Poria cocos, 9 parts of Dioscorea opposita and 5 parts of Coix seeds; Immunomodulatory ingredients: 9 parts of copper baicalin and 10 parts of astragalus; Microbial balance ingredients: 24 parts of montmorillonite and 5 parts of matrine; Auxiliary synergistic ingredients: 10 parts of hawthorn, 8 parts of costusroot and 8 parts of acanthopanax senticosus.

5. The Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The baicalin copper, astragalus and yam are used to enhance the expression of occludin and ZO-1 proteins in the intestine and repair the physical barrier.

6. The Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The coix seed is used to eliminate edema, improve diarrhea, relieve skin abscesses and help strengthen the spleen and stomach functions, and the acanthopanax senticosus is used to enhance physical strength, improve fatigue and enhance immunity.

7. The method for preparing the Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: The following steps are involved: Step 1: Raw material pretreatment S1: Screening and cleaning of medicinal materials: remove impurities from pomegranate peel, Chinese gallnut, Poria cocos, Codonopsis pilosula, Atractylodes macrocephala, Poria cocos, Dioscorea opposita, Coix seeds, Aucklandia lappa and Acanthopanax senticosus, rinse with pure water for 2-3 times, drain the surface water, and process the pomegranate peel separately; S2: Low temperature drying: The washed medicinal materials are placed in a 60°C hot air circulation drying oven for 4-6 hours to make the moisture content ≤8%; S3: Crushing and sieving: The dried medicinal materials are crushed by a universal grinder and passed through a 100-mesh sieve (particle size ≤ 150 μm) for later use; Step 2: Directed extraction of active ingredients S1: Stir-frying pomegranate peel into charcoal: Place the pomegranate peel in a stir-frying machine and stir-fry at 180°C for 10 minutes until the surface is burnt black and the tannic acid content is reduced from 12.3% to 6.8%. Then, crush and pass through an 80-mesh sieve; S2: Extraction of copper baicalin: Scutellaria crude powder was mixed with 60% ethanol at a solid-liquid ratio of 1:10, and refluxed at 80°C for 2 hours. After filtration, it was concentrated under reduced pressure to an extract with a relative density of 1.2, and spray-dried to obtain the copper baicalin extract; S3: Matrine extraction: Sophora flavescens root powder was extracted with 70% ethanol by ultrasound, and the extract was purified by macroporous resin and freeze-dried for later use; Step 3: Preparation of excipients Montmorillonite ultrafine grinding: Montmorillonite is processed by air jet mill to a particle size of ≤50μm to enhance the toxin adsorption capacity; Step 4: Mixing and stabilization S1: Three-dimensional mixing process: The extract powder, modified medicinal materials, montmorillonite and oligofructose are put into the three-dimensional motion mixer in proportion, and mixed at a speed of 25r / min for 30 minutes, with a uniformity CV ≤ 5%; S2: Radiation sterilization: The mixed powder is sterilized by cobalt 60 irradiation (dose 8 kGy) to make the total number of microorganisms ≤1000 CFU / g and the moisture content ≤5%; Step 5: The finished product is packed into aluminum foil bags by an automatic packaging machine, 500g per bag, and stored in a cool and dry place, sealed and away from light.

8. The method for preparing the Chinese herbal medicine composite powder for reducing diarrhea rate in early weaned piglets according to claim 1, characterized in that: In the step 4, the oligofructose added accounts for 1-3% of the total amount of the medicine.

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