Vibration stimulation treatment system

Abstract

The invention discloses a vibration stimulation treatment system, and the system comprises a first collection unit which is used for collecting a first electric signal set of a hand part of a target object in a process of carrying out the stimulation treatment of the target object through employing an initial vibration stimulation parameter; the second acquisition unit is used for acquiring a second electric signal set of the legs of the target object; the first analysis unit is used for carrying out quantitative analysis on signals in the first electric signal set and the second electric signal set to obtain an analysis result; the first adjusting unit is used for adjusting the initial vibration stimulation parameter according to the analysis result to obtain a target vibration stimulation parameter; the first control unit is used for carrying out vibration stimulation treatment on the target object by adopting the target vibration stimulation parameters; according to the invention, quantitative evaluation analysis is carried out on the electric signal set collected in the stimulation treatment process of the target object, and the vibration stimulation parameters are dynamically adjusted according to the analysis result, so that the treatment effect of vibration stimulation treatment is improved.

Description

Technical Field

[0001] The present invention relates to a non-invasive treatment system, and in particular to a vibration stimulation treatment system. Background Art

[0002] Coordinate reset (CR) stimulation is a pattern stimulation that destroys abnormal synchronization and can induce persistent desynchronization by modifying the structure and function of the connections between neurons. Studies have applied this pattern to vibration stimulation devices to form a coordinated reset vibration stimulation (Coordinate reset vibration stimulation) system. This therapy is a non-invasive treatment system that uses weak, painless vibration pulses delivered to the fingertips instead of electrical pulses delivered through implanted electrodes. Since the vibration pulse input applied to the fingertips can be fed into the motor basal ganglia thalamocortical circuit through different projections, for example, through the thalamus (Vc)-cortex (SI)-striatum projection, the system can achieve the purpose of specific stimulation of neurons, so that they can readjust and restore normal activity patterns, thereby achieving the purpose of alleviating movement disorders and improving quality of life.

[0003] At present, in clinical trials for coordinated reset vibration stimulation, a glove-style vibration tactile stimulation device is used, in which a vibration tactile stimulator (piezoelectric motor) is fixed at the place in contact with each fingertip (except the thumb). The glove is connected to a controller, and the controller sends a control signal to the vibration tactile stimulator at each fingertip according to the set CR stimulation mode to achieve the purpose of coordinated reset vibration stimulation. The patent application with publication number CN117481944A discloses a hand function rehabilitation system and control method, which realizes the rehabilitation of finger function and the reshaping of brain function, combines multi-sensory stimulation with hand movement, and realizes mirroring steps, emergency stop steps, electrical stimulation steps, vibration stimulation steps, and light stimulation steps. However, the vibration stimulation parameters used by the prior art for all target objects are fixed and cannot be adjusted, which may lead to obvious individual differences in the treatment effects of different target objects, that is, the efficacy of some target objects is obvious, and the efficacy of other target objects is not significant. In addition, the existing products cannot objectively and timely give an evaluation of the treatment effect, resulting in doctors, target objects and follow-up personnel being unable to obtain the efficacy and compliance in time, affecting the efficiency and accuracy of treatment.

[0004] Therefore, there is currently no effective solution to the problem of poor therapeutic effect of the above-mentioned vibration stimulation therapy. Summary of the invention

[0005] In order to overcome the defects of the above-mentioned prior art, the purpose of the present invention is to provide a vibration stimulation therapy system, which quantitatively evaluates and analyzes the set of electrical signals collected during the stimulation therapy of the target object, and dynamically adjusts the vibration stimulation parameters in the vibration stimulation therapy system according to the analysis results, thereby improving the therapeutic effect of the vibration stimulation therapy, so as to achieve the best therapeutic effect for the target object.

[0006] In order to achieve the above object, the technical solution of the present invention is:

[0007] A vibration stimulation therapy system, comprising:

[0008] The first acquisition unit 10 is used to acquire a first set of electrical signals of a hand of the target object during the vibration stimulation therapy, in the process of stimulating the target object with the initial vibration stimulation parameters, wherein the first set of electrical signals at least includes: the acceleration of the hand, the angular velocity of the hand, the posture signal of the hand, and the electromyographic signal of the hand, wherein the initial vibration stimulation parameters at least include the initial vibration frequency;

[0009] The second acquisition unit 20 is used to acquire a second electrical signal set of the target object's legs, wherein the second electrical signal set includes at least: an acceleration of the legs, an angular velocity of a gyroscope, and a posture signal of the legs;

[0010] A first analysis unit 30, configured to perform quantitative analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results;

[0011] A first adjustment unit 40, configured to adjust the initial vibration stimulation parameters according to the analysis result to obtain target vibration stimulation parameters;

[0012] The first control unit 50 is used to perform vibration stimulation therapy on the target object using the target vibration stimulation parameters.

[0013] The first analysis unit 30 comprises:

[0014] A first calculation module, configured to monitor the motor symptoms of the target object according to the first electrical signal set and the second electrical signal set, and calculate a score set of the target object, wherein the score set at least includes: a tremor score, a bradykinesia score, a dyskinesia score, and a freezing gait score;

[0015] The first acquisition module is used to obtain a first movement score of the target object according to the tremor score, the bradykinesia score, the dyskinesia score and the freezing gait score.

[0016] The first adjustment unit 40 includes:

[0017] A first adjustment module, configured to adjust the first vibration frequency according to the first exercise score to obtain a second vibration frequency;

[0018] A first control module, configured to perform stimulation therapy on the target object by using the second vibration frequency and calculate a second motion score of the target object;

[0019] The second control module is used to cyclically execute the operation of adjusting the second vibration frequency through the first adjustment module according to the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment, and the target motion score of the target object is a minimum value, and the vibration frequency corresponding to the target motion score is used as the target vibration frequency, and the target vibration frequency is used to stimulate the target object until the vibration stimulation treatment cycle for the target object is completed.

[0020] The first adjustment module includes: a second acquisition module, which is used to increase a preset frequency value on the basis of the first vibration frequency to obtain the second vibration frequency.

[0021] The second control module includes:

[0022] a first adjustment submodule, configured to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is a negative number;

[0023] The second adjustment submodule is configured to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is zero or a positive number.

[0024] The second control module further includes:

[0025] a third adjustment submodule, configured to increase the second vibration frequency by a preset frequency value when the difference between the second exercise score and the first exercise score is a negative number;

[0026] The fourth adjustment submodule is configured to reduce the second vibration frequency by a preset frequency value when the difference between the second exercise score and the first exercise score is zero or a positive number.

[0027] The system further comprises:

[0028] The hand vibration stimulation module 60 is controlled by the first control unit 50 to perform vibration stimulation on the hand; it includes: a controller, a sensor unit, an amplifier unit and a motor array unit;

[0029] The leg vibration stimulation module 70 is controlled by the first control unit 50 to perform vibration stimulation on the legs; it includes: a controller, a sensor unit, an amplifier unit and a motor array unit.

[0030] The hand vibration stimulation module 60 or the leg vibration stimulation module 70 specifically includes:

[0031] A receiving unit, configured to receive a vibration stimulation parameter set before using the initial vibration stimulation parameters to perform stimulation therapy on the target object, wherein the vibration stimulation parameter set includes at least the following vibration stimulation parameters: a single sequence stimulation frequency, a motor vibration stimulation frequency, a duration of vibration stimulation of a single finger in each stimulation cycle, a number of continuous stimulation on cycles, and a number of continuous stimulation off cycles;

[0032] a determining unit, configured to determine initial vibration stimulation parameters according to the vibration stimulation parameter set;

[0033] A generating unit, configured to generate an initial vibration control signal according to the initial vibration stimulation parameter;

[0034] A first transmission unit, configured to transmit the initial vibration control signal to a controller of each vibration stimulation module via Bluetooth;

[0035] The second transmission unit is used to transmit the initial vibration control signal to the amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

[0036] Further, the system also includes:

[0037] A first calculation unit is used to calculate the score difference between the motor score of the target object after the second treatment and the motor score before the first treatment every day during the vibration stimulation treatment, to obtain N score differences, wherein N is the number of treatment days during the vibration stimulation treatment;

[0038] An acquisition unit, configured to acquire an initial motion score of the target object before the vibration stimulation treatment period and a final motion score of the target object after the vibration stimulation treatment period;

[0039] A second calculation unit, configured to calculate a benefit value of the target object during the vibration stimulation treatment according to a preset weight value, the N score differences, the initial motion score, and the final motion score;

[0040] The second analysis unit is used to analyze the therapeutic effect of the vibration stimulation therapy on the target object according to the benefit value.

[0041] The vibration stimulation therapy system is used for non-invasive treatment of Parkinson's disease and / or essential tremor disease.

[0042] Compared with the prior art, the advantages of the present invention are:

[0043] (1) The present invention is based on the hand acceleration, hand angular velocity, hand posture signal, hand electromyographic signal of a first electrical signal set, and the leg acceleration, gyroscope angular velocity and leg posture signal of a second electrical signal set; the signals of the two electrical signal sets are quantitatively analyzed to obtain analysis results, the initial vibration stimulation parameters are adjusted to obtain target vibration stimulation parameters; vibration stimulation therapy is performed, thereby solving the problem of poor therapeutic effect of vibration stimulation therapy in related technologies.

[0044] (2) The first adjustment unit of the present invention realizes dynamic adjustment of the vibration stimulation parameters in the vibration stimulation therapy system, thereby improving the therapeutic effect of the vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0045] To summarize, the present invention quantitatively evaluates and analyzes the set of electrical signals collected during the stimulation treatment of the target object, and dynamically adjusts the vibration stimulation parameters in the vibration stimulation treatment system according to the analysis results, thereby improving the therapeutic effect of the vibration stimulation treatment, so as to achieve the best therapeutic effect for the target object. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 Schematic diagram of the vibration stimulation therapy system of the present invention.

[0047] Figure 2 It is a schematic diagram of the vibration stimulation parameter adjustment of the present invention.

[0048] Figure 3 It is a schematic diagram of the target subject wearing the hand vibration stimulation module and the leg vibration stimulation module.

[0049] Figure 4 is a schematic diagram of an optional vibration stimulation therapy system provided according to an embodiment of the present invention. DETAILED DESCRIPTION

[0050] The present invention is described in detail below with reference to the accompanying drawings.

[0051] Figure 1 FIG. 1 is a flow chart of a vibration stimulation treatment system according to an embodiment of the present invention. Figure 1 As shown, a vibration stimulation therapy system comprises:

[0052] The first acquisition unit 10 is used to acquire a first set of electrical signals of a hand of the target object during the vibration stimulation therapy, in the process of stimulating the target object with the initial vibration stimulation parameters, wherein the first set of electrical signals at least includes: the acceleration of the hand, the angular velocity of the hand, the posture signal of the hand, and the electromyographic signal of the hand, wherein the initial vibration stimulation parameters at least include the initial vibration frequency;

[0053] The second acquisition unit 20 is used to acquire a second set of electrical signals of the target object's legs, wherein the first set of electrical signals at least includes: acceleration of the legs, angular velocity of the gyroscope, and posture signals of the legs;

[0054] A first analysis unit 30, configured to perform quantitative analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results;

[0055] A first adjustment unit 40, configured to adjust the initial vibration stimulation parameters according to the analysis result to obtain target vibration stimulation parameters;

[0056] The first control unit 50 is used to perform vibration stimulation therapy on the target object using the target vibration stimulation parameters.

[0057] The above-mentioned vibration stimulation therapy system quantitatively evaluates and analyzes the set of electrical signals collected during the stimulation therapy of the target object, and dynamically adjusts the vibration stimulation parameters in the vibration stimulation therapy system according to the analysis results, thereby improving the therapeutic effect of the vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0058] Optionally, in the vibration stimulation therapy system provided by the embodiment of the present invention, the first analysis unit 30 further includes:

[0059] A first calculation module, configured to monitor the motor symptoms of the target object according to the first electrical signal set and the second electrical signal set, and calculate a score set of the target object, wherein the score set at least includes: a tremor score, a bradykinesia score, a dyskinesia score, and a freezing gait score;

[0060] The first acquisition module is used to obtain a first movement score of the target object according to the tremor score, the bradykinesia score, the dyskinesia score and the freezing gait score.

[0061] In the above scheme, the first electrical signal set of the target object's hand and the second electrical signal set of the leg are collected, and after fusion analysis, the target object (for example, the target object with Parkinson's disease) is monitored for motor symptoms in daily life, and several indicators such as tremor, bradykinesia, dissociative symptoms, and freezing of gait are quantitatively evaluated. The analysis result of the target object is obtained, that is, the first motor score.

[0062] Through the above solution, the first motion score can be accurately and quickly analyzed based on the electrical signal set of the target object, so as to adjust the vibration stimulation parameters of the target object more accurately later.

[0063] Optionally, in the vibration stimulation therapy system provided by an embodiment of the present invention, the first adjustment unit 40 includes:

[0064] A first adjustment module, configured to adjust the first vibration frequency according to the first exercise score to obtain a second vibration frequency;

[0065] A first control module, configured to perform stimulation therapy on the target object by using the second vibration frequency and calculate a second motion score of the target object;

[0066] The second control module is used to cyclically execute the operation of adjusting the second vibration frequency through the first adjustment module according to the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment, and the target motion score of the target object is a minimum value, and the vibration frequency corresponding to the target motion score is used as the target vibration frequency, and the target vibration frequency is used to stimulate the target object until the vibration stimulation treatment cycle for the target object is completed.

[0067] like Figure 2 As shown, for example, fburst_t-1 is the first vibration frequency mentioned above, and the first exercise score at the first vibration frequency is Sdt-1. The first vibration frequency is adjusted according to the first exercise score to obtain the second vibration frequency (fburst_t). It should be noted that the first vibration frequency can be adjusted by increasing or decreasing 20Hz on the basis of fburst_t-1, and the second vibration frequency is used to stimulate the target object, and the second exercise score of the target object (corresponding to Figure 2Sdt in, if Sdt-Sdt-1>0, the first vibration frequency is adjusted to increase 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to decrease 20Hz based on fburst_t-1; if Sdt-Sdt-1>0, the first vibration frequency is adjusted to decrease 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to increase 20Hz based on fburst_t-1. If Sdt-Sdt-1≤0, the first vibration frequency is adjusted to increase 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to increase 20Hz based on fburst_t-1; if Sdt-Sdt-1≤0, the first vibration frequency is adjusted to decrease 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to decrease 20Hz based on fburst_t-1. The target object is stimulated and treated with the adjusted second vibration frequency, the third motion score of the target object is calculated, and the operation of adjusting the vibration frequency is cyclically performed until the adjusted vibration frequency is used for treatment, and the target motion score of the target object is a minimum value (that is, Sdmin=Sdt), the vibration frequency corresponding to the target motion score (Sdt) is used as the target vibration frequency (fburst_t), and the target object is stimulated and treated with the target vibration frequency until the vibration stimulation treatment cycle for the target object is completed.

[0068] Through the above scheme, dynamic adjustment of vibration stimulation parameters in the vibration stimulation therapy system is achieved, thereby improving the therapeutic effect of vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0069] Optionally, in the vibration stimulation therapy system provided by an embodiment of the present invention, the second control module includes:

[0070] a first adjustment submodule, configured to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is a negative number;

[0071] The second adjustment submodule is configured to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is zero or a positive number.

[0072] For example, when the difference between the second motion score and the first motion score is a negative number, the second vibration frequency is adjusted in the same direction as the adjustment direction of the first vibration frequency. For example, if Sdt-Sdt-1 is less than 0, the first vibration frequency is adjusted to increase 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to increase 20Hz based on fburst_t-1; if the first vibration frequency is adjusted to decrease 20Hz based on fburst_t-1, the second vibration frequency is adjusted to decrease 20Hz based on fburst_t-1.

[0073] When the difference between the second motion score and the first motion score is zero or a positive number, the second vibration frequency is adjusted in the direction opposite to the adjustment direction of the first vibration frequency. For example, if Sdt-Sdt-1≥0, the first vibration frequency is adjusted to increase 20Hz based on fburst_t-1, and the second vibration frequency is adjusted to reduce 20Hz based on fburst_t-1; if the first vibration frequency is adjusted to reduce 20Hz based on fburst_t-1, the second vibration frequency is adjusted to increase 20Hz based on fburst_t-1.

[0074] Through the above scheme, it is ensured that the vibration stimulation parameters in the vibration stimulation therapy system are dynamically adjusted according to the difference between the second motion score and the first motion score in a timely manner, thereby improving the therapeutic effect of the vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0075] Optionally, in the vibration stimulation therapy system provided by an embodiment of the present invention, the first adjustment module includes: a second acquisition module, configured to increase a preset frequency value on the basis of the first vibration frequency to obtain the second vibration frequency.

[0076] Optionally, in the vibration stimulation therapy system provided in an embodiment of the present invention, the second control module includes: a third adjustment submodule, used to increase the second vibration frequency by the preset frequency value when the difference between the second motion score and the first motion score is a negative number; and a fourth adjustment submodule, used to reduce the second vibration frequency by the preset frequency value when the difference between the second motion score and the first motion score is zero or a positive number.

[0077] If the preset frequency value is increased on the basis of the first vibration frequency (fburst_t-1), the second vibration frequency (fburst_t) is obtained. If Sdt-Sdt-1<0, the adjustment of the second vibration frequency is to increase 20Hz on the basis of fburst_t-1; if Sdt-Sdt-1≥0, the adjustment of the second vibration frequency is to reduce 20Hz on the basis of fburst_t-1.

[0078] Through the above scheme, it is ensured that the vibration stimulation parameters in the vibration stimulation therapy system are dynamically adjusted according to the difference between the second motion score and the first motion score in a timely manner, thereby improving the therapeutic effect of the vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0079] Optionally, in the vibration stimulation therapy system provided in an embodiment of the present invention, the vibration stimulation therapy system also includes: a hand vibration stimulation module 60 and a leg vibration stimulation module 70, wherein each vibration stimulation module includes at least: a power management unit, a controller, a sensor unit, an amplifier unit and a motor array unit.

[0080] Optionally, in the vibration stimulation therapy system provided by an embodiment of the present invention, the system further includes: a receiving unit, used to receive a vibration stimulation parameter set before using the initial vibration stimulation parameters to perform stimulation therapy on the target object, wherein the vibration stimulation parameter set includes at least the following vibration stimulation parameters: a single sequence stimulation frequency, a motor vibration stimulation frequency, a duration of a single finger vibration stimulation in each stimulation cycle, a number of continuous stimulation on cycles and a number of continuous stimulation off cycles; a determining unit, used to determine the initial vibration stimulation parameters according to the vibration stimulation parameter set; a generating unit, used to generate an initial vibration control signal according to the initial vibration stimulation parameters; a first transmission unit, used to transmit the initial vibration control signal to a controller of each vibration stimulation module via Bluetooth; and a second transmission unit, used to transmit the initial vibration control signal to an amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

[0081] Optionally, the vibration stimulation treatment system provided in the embodiment of the present invention is composed of a motor symptom analysis subsystem and a vibration stimulation subsystem. Figure 4 shown.

[0082] The motor symptom analysis subsystem collects the acceleration, angular velocity, posture, and electromyographic signals of the target object's wrist, as well as the acceleration, gyroscope and posture signals of the legs, and performs fusion analysis to monitor the motor symptoms of the target Parkinson's disease in daily life, and conducts quantitative evaluation of several indicators such as tremor, bradykinesia, dissociative symptoms, and freezing of gait.

[0083] The vibration stimulation subsystem consists of a hand vibration stimulation module and a leg vibration stimulation module. Each vibration stimulation module consists of a power management unit, a controller, an amplifier unit, and a motor array unit. The hand vibration stimulation module is worn on the left and right hands respectively, and a piezoelectric vibration motor is fixed at the contact point with each finger. The leg vibration stimulation module is worn at the left and right ankle positions, and multiple piezoelectric vibration motors are fixed around a circle. The switching mode of each vibration motor is independently controlled by the controller in the vibration stimulation module.

[0084] The motor symptom analysis subsystem dynamically adjusts the stimulation parameters according to the evaluation of the wearer's motor symptom improvement during the treatment period, and transmits them to the controller of each vibration stimulation module via Bluetooth. The stimulation parameters are used for the vibration control signal generated by the vibration stimulation module. The stimulation parameters include a single sequence stimulation frequency f sequence , motor vibration stimulation frequency f burst , and the duration t of the vibration stimulation of a single finger in each stimulation cycle cont , the number of continuous stimulation cycles n on and the number of consecutive stimulation-off cycles n off The controller generates a vibration control signal based on the received parameters and applies it to each amplifier of the amplifier unit, thereby driving the motor in each part to vibrate according to the control signal, thereby achieving coordinated reset vibration stimulation of the peripheral nerves. The motor symptom quantitative evaluation system continuously and dynamically adjusts the stimulation parameters in the vibration stimulation system according to the wearer's motor function evaluation results to achieve the best treatment effect for individualized target objects.

[0085] Through the above scheme, precise control of vibration stimulation of the target object is achieved, thereby improving the therapeutic effect of vibration stimulation therapy to achieve the best therapeutic effect for the target object.

[0086] In addition, it should be noted that, in order to facilitate wearing, each system and module is independently powered and transmitted wirelessly. The motor symptom analysis subsystem serves as the host of the entire closed-loop coordinated reset vibration stimulation system, and uses Bluetooth to communicate with the hand vibration stimulation modules of the left and right hands and the leg vibration stimulation modules of the left and right legs.

[0087] Optionally, in the vibration stimulation therapy system provided by an embodiment of the present invention, the system further includes: a first calculation unit, used to calculate the score difference between the motion score of the target object after the second treatment and the motion score before the first treatment every day during the vibration stimulation therapy, to obtain N score differences, wherein N is the number of treatment days during the vibration stimulation therapy; an acquisition unit, used to obtain the initial motion score of the target object before the vibration stimulation therapy period and the final motion score of the target object after the vibration stimulation therapy period; a second calculation unit, used to calculate the benefit value of the target object during the vibration stimulation therapy based on a preset weight value, the N score differences, the initial motion score and the final motion score; and a second analysis unit, used to analyze the therapeutic effect of the vibration stimulation therapy on the target object based on the benefit value.

[0088] On the initial treatment day of the target subject, the preset vibration stimulation parameters are used for treatment. Thereafter, the stimulation parameters in the vibration stimulation system are dynamically adjusted every day according to the analysis results of the symptom evaluation system, and the improvement of the target subject's motor state is continuously evaluated. Then, based on multiple sets of motor state evaluation results, the date with the best therapeutic effect for the target subject and the corresponding stimulation parameter combination are found. This stimulation parameter combination is used as the treatment parameters in the subsequent formal treatment period, and after the treatment, an efficacy evaluation of the treatment period is given.

[0089] Specifically, the target subject receives vCR treatment twice a day through the vibration stimulation system, while the symptom evaluation system continuously monitors the target subject's motor symptoms and calculates the motor score for the day. That is, the sum of the scores of tremor, bradykinesia, dyskinesia, and freezing of gait after the second vCR treatment on the same day, as shown in Formula 1. A record is generated every day as the short-term / acute evaluation score of the treatment.

[0090]

[0091] After one month, n records are obtained, and the scores of these n sports (s d ) and average, as shown in formula 3, to get s m and m_ave Two values ​​serve as stage evaluation scores for treatment.

[0092]

[0093] Vibration frequency f burst Parameter Adjustment

[0094] The sports score for the day is obtained according to formula 1 As a result, the vibration frequency f burst Adjust to find the vibration frequency f that can achieve the best vCR treatment effect burstThe specific implementation steps are as follows:

[0095] (1) Get the first day's exercise score and the initial vibration frequency f burst_1 (250Hz)

[0096] (2) During the second day of vCR treatment, the vibration frequency f burst_2 Compared with the initial vibration frequency, the current vibration frequency f is reduced or increased by 20Hz. burst_2 Next day sports scores

[0097] (3) If This indicates that the vCR treatment on that day has a certain therapeutic effect. In the same way as the last time, the vibration frequency is adjusted, and the frequency is continued to be reduced or increased by 20Hz, and the current vibration frequency f is calculated. burst_3 The third day of sports scores like This indicates that the target subject’s motor symptoms have not been alleviated to a certain extent on that day, that is, the current vibration frequency f burst_2 It is not the optimal vibration frequency, so the method used to adjust the vibration frequency last time is opposite to that used to adjust the vibration frequency at the initial vibration frequency f burst_1 Increase or decrease 20Hz based on the current vibration frequency f burst_3 The third day of sports scores The parameter adjustment process of this step can be summarized as Formula 4.

[0098]

[0099] (4) Repeat step 3 until the exercise score on the mth day drops to the lowest value The vibration frequency f obtained at this time burst_m As the optimal vibration frequency, and calculate the current vibration frequency f burst_m The exercise score on the mth day Stop adjusting the vibration frequency parameters and use the optimal vibration frequency for subsequent vCR treatment until the end of this stage of treatment.

[0100] During the treatment period, the second vCR treatment was calculated on each day. Compared with the day before the first vCR treatment The score difference Δd i After the treatment period, the overall benefit GI (corresponding to the above-mentioned benefit value) of the target subject during the treatment period is calculated according to formula (4) to achieve an objective evaluation index of the therapeutic effect of the target subject during the treatment period, where w is the benefit weight index and n is the number of days in the treatment period.

[0101]

[0102] During the treatment cycle, the vibration stimulation system is turned on and off by the symptom evaluation system. The vibration stimulation system records each on and off and sends it to the symptom evaluation system to generate treatment compliance statistics.

[0103] Through the above scheme, a more accurate analysis and evaluation of the therapeutic effect of the vibration stimulation therapy on the target object is achieved.

[0104] The vibration stimulation therapy system provided in the embodiment of the present invention is essentially a closed-loop coordinated resetting vibration stimulation therapy system, which can be used for non-invasive treatment of Parkinson's disease and / or essential tremor disease.

[0105] The vibration stimulation therapy system includes a processor and a memory. The above-mentioned first acquisition unit, second acquisition unit, first analysis unit, first adjustment unit and first control unit are all stored in the memory as program units, and the processor executes the above-mentioned program units stored in the memory to realize corresponding functions.

[0106] The processor includes a kernel, which retrieves the corresponding program unit from the memory. One or more kernels can be set, and the therapeutic effect of vibration stimulation therapy can be improved by adjusting kernel parameters.

[0107] The memory may include non-permanent memory in a computer-readable medium, random access memory (RAM) and / or non-volatile memory, such as read-only memory (ROM) or flash RAM, and the memory includes at least one memory chip.

[0108] An embodiment of the present invention provides a computer-readable storage medium on which a program is stored. When the program is executed by a processor, the vibration stimulation therapy system is implemented.

[0109] An embodiment of the present invention provides a processor, which is used to run a program, wherein the vibration stimulation therapy system is executed when the program is run.

[0110] Those skilled in the art will appreciate that embodiments of the present invention may be provided as methods, systems, or computer program products. Therefore, the present invention may take the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Moreover, the present invention may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0111] The present invention is described in terms of flowcharts and / or block diagrams of methods, devices (systems), and computer program products. It should be understood that each process and / or block in the flowchart and / or block diagram, as well as the combination of processes and / or blocks in the flowchart and / or block diagram, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing device to generate a machine, so that the instructions executed by the processor of the computer or other programmable data processing device generate instructions for implementing the processes in the flowchart and / or block diagram. Figure 1 A process or multiple processes and / or boxes Figure 1 A device that provides the functions specified in a block or multiple blocks.

[0112] These computer program instructions may also be stored in a computer readable memory capable of directing a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer readable memory produce an article of manufacture including an instruction device, which implements the process Figure 1 A process or multiple processes and / or boxes Figure 1 A function specified in one or more boxes.

[0113] These computer program instructions can also be loaded onto a computer or other programmable data processing device so that a series of operating steps are executed on the computer or other programmable device to produce a computer-implemented process, thereby providing instructions for implementing the process. Figure 1 A process or multiple processes and / or boxes Figure 1 A step that specifies a function in one or more boxes.

[0114] In a typical configuration, a computing device includes one or more processors (CPU), input / output interfaces, network interfaces, and memory.

[0115] The memory may include non-permanent memory in a computer-readable medium, random access memory (RAM) and / or non-volatile memory in the form of read-only memory (ROM) or flash RAM. The memory is an example of a computer-readable medium.

[0116] Computer readable media include permanent and non-permanent, removable and non-removable media that can be implemented by any method or technology to store information. Information can be computer readable instructions, data structures, program modules or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disk read-only memory (CD-ROM), digital versatile disk (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices or any other non-transmission media that can be used to store information that can be accessed by a computing device. As defined herein, computer readable media does not include temporary computer readable media (transitory media), such as modulated data signals and carrier waves.

[0117] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0118] It will be appreciated by those skilled in the art that embodiments of the present invention may be provided as methods, systems or computer program products. Therefore, the present invention may take the form of a complete hardware embodiment, a complete software embodiment or an embodiment combining software and hardware. Moreover, the present invention may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program codes.

[0119] The above are only embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A vibration stimulation therapy system, characterized in that: include: A first collection unit (10) is used to collect a first set of electrical signals of a hand of a target object during vibration stimulation therapy, in the process of using initial vibration stimulation parameters to stimulate the target object, wherein the first set of electrical signals at least includes: acceleration of the hand, angular velocity of the hand, posture signal of the hand, and myoelectric signal of the hand, wherein the initial vibration stimulation parameters at least include an initial vibration frequency; A second acquisition unit (20) is used to acquire a second electrical signal set of the target object's legs, wherein the second electrical signal set at least includes: an acceleration of the legs, an angular velocity of a gyroscope, and a posture signal of the legs; A first analysis unit (30) is used to perform quantitative analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results; A first adjustment unit (40) is used to adjust the initial vibration stimulation parameters according to the analysis results to obtain target vibration stimulation parameters; A first control unit (50) is used to perform vibration stimulation treatment on the target object using the target vibration stimulation parameters.

2. A vibration stimulation therapy system according to claim 1, characterized in that: The first analysis unit (30) comprises: A first calculation module, configured to monitor the motor symptoms of the target object according to the first electrical signal set and the second electrical signal set, and calculate a score set of the target object, wherein the score set at least includes: a tremor score, a bradykinesia score, a dyskinesia score, and a freezing gait score; The first acquisition module is used to obtain a first movement score of the target object according to the tremor score, the bradykinesia score, the dyskinesia score and the freezing gait score.

3. A vibration stimulation therapy system according to claim 2, characterized in that: The first adjustment unit (40) comprises: A first adjustment module, configured to adjust the first vibration frequency according to the first exercise score to obtain a second vibration frequency; A first control module, configured to perform stimulation therapy on the target object by using the second vibration frequency and calculate a second motion score of the target object; The second control module is used to cyclically execute the operation of adjusting the second vibration frequency through the first adjustment module according to the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment, and the target motion score of the target object is a minimum value, and the vibration frequency corresponding to the target motion score is used as the target vibration frequency, and the target vibration frequency is used to stimulate the target object until the vibration stimulation treatment cycle for the target object is completed.

4. A vibration stimulation therapy system according to claim 3, characterized in that: The first adjustment module includes: a second acquisition module, which is used to increase a preset frequency value on the basis of the first vibration frequency to obtain the second vibration frequency.

5. A vibration stimulation therapy system according to claim 4, characterized in that: The second control module includes: a first adjustment submodule, configured to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is a negative number; The second adjustment submodule is configured to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second exercise score and the first exercise score is zero or a positive number.

6. A vibration stimulation therapy system according to claim 5, characterized in that: The second control module further includes: a third adjustment submodule, configured to increase the second vibration frequency by a preset frequency value when the difference between the second exercise score and the first exercise score is a negative number; The fourth adjustment submodule is configured to reduce the second vibration frequency by a preset frequency value when the difference between the second exercise score and the first exercise score is zero or a positive number.

7. A vibration stimulation therapy system according to claim 6, characterized in that: The system further comprises: A hand vibration stimulation module (60) is controlled by a first control unit (50) to perform vibration stimulation on the hand; it comprises: a controller, a sensor unit, an amplifier unit and a motor array unit; The leg vibration stimulation module (70) is controlled by a first control unit (50) to perform vibration stimulation on the legs; and comprises a controller, a sensor unit, an amplifier unit and a motor array unit.

8. The system according to claim 7, characterized in that The hand vibration stimulation module (60) or the leg vibration stimulation module (70) specifically comprises: A receiving unit, configured to receive a vibration stimulation parameter set before using the initial vibration stimulation parameters to perform stimulation therapy on the target object, wherein the vibration stimulation parameter set includes at least the following vibration stimulation parameters: a single sequence stimulation frequency, a motor vibration stimulation frequency, a duration of vibration stimulation of a single finger in each stimulation cycle, a number of continuous stimulation on cycles, and a number of continuous stimulation off cycles; a determining unit, configured to determine initial vibration stimulation parameters according to the vibration stimulation parameter set; A generating unit, configured to generate an initial vibration control signal according to the initial vibration stimulation parameter; A first transmission unit, configured to transmit the initial vibration control signal to a controller of each vibration stimulation module via Bluetooth; The second transmission unit is used to transmit the initial vibration control signal to the amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

9. A vibration stimulation therapy system according to claim 8, characterized in that: The system further comprises: A first calculation unit is used to calculate the score difference between the motor score of the target object after the second treatment and the motor score before the first treatment every day during the vibration stimulation treatment, to obtain N score differences, wherein N is the number of treatment days during the vibration stimulation treatment; An acquisition unit, configured to acquire an initial motion score of the target object before the vibration stimulation treatment period and a final motion score of the target object after the vibration stimulation treatment period; A second calculation unit, configured to calculate a benefit value of the target object during the vibration stimulation treatment according to a preset weight value, the N score differences, the initial motion score, and the final motion score; The second analysis unit is used to analyze the therapeutic effect of the vibration stimulation therapy on the target object according to the benefit value.

10. The system according to claim 1, characterized in that The vibration stimulation therapy system is used for non-invasive treatment of Parkinson's disease and / or essential tremor disease.

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