Human tissue scaffold spliced by medical modules

Abstract

The invention discloses a human tissue scaffold spliced by medical modules. The human tissue scaffold is formed by splicing a plurality of medical modules. Compared with the prior art, the method has the advantages that 1, the medical module finished product can better meet the sterile requirement after quality inspection, the medical module finished product is spliced and rapidly implanted into the body on the operation site, the operation time is greatly shortened, the module can be flexibly, rapidly and accurately repaired and manually assembled in the operation according to actual requirements, the operation is simple and convenient, and the clinical popularization value is high; 2, the titanium clip module is accurately configured, the position and the number of titanium clips can be flexibly adjusted according to the specific form of the tissue in the operation and the size of the residual cavity, and accurate positioning of the radiotherapy after the operation is ensured;

Description

Technical Field

[0001] The present invention relates to the field of medical materials, in particular to the field of human tissue scaffolds. Background Art

[0002] Human tissue repair and reconstruction surgery is a common surgical procedure that aims to repair tissue defects caused by radical surgery or trauma. After searching, it was found that the authorization announcement number "CN109172044B" discloses a degradable gradient porosity breast scaffold. Although 3D printing can meet the needs of morphological accuracy, it requires special printing equipment and has special requirements for the cleanliness of the printing environment, and printing takes a long time to complete. When the amount of tissue removed during surgery changes, it is necessary to reprint or replace other specifications of human tissue scaffolds, which will extend the operation time, increase the risk of anesthesia accidents, and increase the economic burden. Therefore, how to quickly, accurately, safely and low-cost fill tissue defects and restore the original morphology of tissues is an important topic in human tissue repair and reconstruction surgery. Summary of the invention

[0003] In order to solve the above technical problems, the human tissue scaffold filling technology of the medical module splicing of the present invention adopts a modular design of medical materials. According to the amount and shape of the lesion tissue removed in human tissue reconstruction surgery, the medical module materials can be flexibly spliced ​​to construct a filling structure that is highly consistent with the morphology of the tissue defect. Compared with the traditional fixed-shape scaffold, this design allows the filling materials to be combined and adjusted in real time according to actual needs during surgery, ensuring that the filling materials can accurately repair tissue defects, significantly improving the personalization and accuracy of the repair effect. Compared with 3D printing, the finished medical module can better ensure the sterility requirements after quality inspection, and the manual splicing and rapid implantation at the surgical site can greatly shorten the operation time.

[0004] Technical solution of the present invention A human tissue scaffold spliced ​​by medical modules, which is composed of scaffold components, can flexibly and accurately fill the tissue area according to the actual morphology of the excised tissue, thereby optimizing the postoperative recovery effect.

[0005] The support assembly of the human tissue support is formed by splicing a connector module and a columnar module.

[0006] The support assembly of the human tissue support is formed by splicing a rectangular module, a T-shaped module, an L-shaped module and a cross-shaped module.

[0007] The surface of the connector module of the human tissue stent is provided with a socket, and a plurality of columnar modules can be combined with the socket in a mutually plugged manner.

[0008] The socket of the human tissue scaffold spliced ​​by the medical modules can accurately fit one end of the columnar module, and the connector module and the columnar module can be spliced ​​during surgery according to the actual required quantity and volume shape of the removed tissue.

[0009] The rectangular module, T-shaped module, L-shaped module and cross-shaped module of the human tissue support spliced ​​by the medical module are provided with a plurality of protrusions on one side and a plurality of recesses on the other side which is vertically symmetrical to the protrusions. The protrusions and the recesses can be combined by mutual plugging.

[0010] The rectangular module, T-shaped module, L-shaped module, and cross-shaped module of the human tissue scaffold spliced ​​by the medical modules have mutually adapted lengths, widths, and heights, and can be spliced ​​during surgery according to the actual required quantity and volume shape of the resected tissue.

[0011] The medical modules of the human tissue support spliced ​​by the medical modules are made of medical metal or medical silicone material.

[0012] The human tissue scaffold spliced ​​by the medical modules is a high molecular biomaterial that can be degraded in the human body.

[0013] The polymer biomaterial of the human tissue scaffold spliced ​​by the medical modules is one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-glycolic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer.

[0014] The connector module of the human tissue scaffold spliced ​​by the medical modules and the cross-shaped module are embedded with titanium clips. The position and number of the titanium clips can be flexibly adjusted according to the specific morphology of the tissue during surgery and the size of the residual cavity to ensure the precise positioning of postoperative radiotherapy.

[0015] The method for splicing a human tissue scaffold spliced ​​by medical modules is characterized by comprising the following steps: S1. Perform resection surgery according to the scope of preoperative clinical examination and imaging evaluation; S2. Measure the length (x), width (y), and height (z) of the resected specimen or surgical cavity; S3. Assemble different medical modules into the required stent assembly according to the actual needs of the patient; S4. Repeat step 3 to make multiple scaffold components, and splice the multiple scaffold components into a tissue plane layer; S5. Repeat steps 3 and 4 to splice multiple tissue plane layers, and the length (x) and width (y) of each tissue plane layer are the same as the length (x) and width (y) of the resected specimen; S6. Connect different tissue plane layers using modules, and repeat this operation until the height of z is reached to gradually assemble them into a modular human tissue scaffold.

[0016] Beneficial effects of the present invention 1. The present invention flexibly splices medical module materials into medical tissue scaffolds of different shapes, which can accurately respond to individual differences in patient tissues and intraoperative changes during surgery.

[0017] 2. The present invention embeds a titanium clip on a module of a human tissue scaffold spliced ​​by medical modules. The position and number of the titanium clip can be flexibly adjusted according to the specific morphology of the tissue during surgery and the size of the residual cavity to ensure accurate positioning of postoperative radiotherapy.

[0018] 3. The present invention has strong adaptability of production process and possibility of standardized production. Different from the traditional single-molded medical tissue scaffold, this technology can be quickly assembled according to the actual needs of the operation, and is easy to operate. No special printing equipment is required, and the conventional operating room environment can meet the operation needs, which has high clinical promotion value. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 , 2 3 is a plan view of a human tissue scaffold made of medical modules Figure 4 , 5 6 is a diagram of a human tissue scaffold assembled from medical modules Figure 7 Schematic diagram of the connector module Figure 8 Schematic diagram of column module Fig. 9 , 10 Schematic diagram of a rectangular module Fig.11 , 12 Schematic diagram of T-type module Fig.13 , 14 Schematic diagram of L-type module Fig.15 , 16 Schematic diagram of a cross-shaped module Fig.17 Cross-shaped module cross-section Fig.18 Sectional view of the connector module DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example 1

[0021] See also Figure 1-2 , perform the resection surgery according to the scope of preoperative clinical examination and imaging evaluation, and then measure the resected specimen to obtain the length (x), width (y), and height (z) of the specimen. Based on the measurement results, select the polymer connector module and the cylindrical medical module for splicing.

[0022] See also Figure 7-8 The diameter of the connector module of the human tissue scaffold is 1 cm, and the length of the cylindrical medical module is 1.6 cm. The medical modules can be spliced ​​into the required shape according to the actual surgical situation.

[0023] See also Figure 4 , 5 , 18. A socket is provided on the connector module, and the depth of the socket is 0.3 cm, so that the connector module can be spliced ​​with the cylindrical medical module. Both ends of the cylindrical medical module are inserted into the socket of the connector module to form a tissue component.

[0024] See also Figure 1 , 4 5. Repeat the splicing of components according to the actual situation of the patient during the operation, and connect two adjacent medical modules with a cylindrical medical module, and gradually splice them into a tissue plane layer; See also Figure 2 During the operation, the tissue components are repeatedly spliced ​​according to the actual situation of the patient, and two adjacent medical modules are connected with a cylindrical medical module to repeatedly splice multiple tissue plane layers. The length (x) and width (y) parameters of each tissue plane layer are the same as the length (x) and width (y) parameters of the corresponding layer of the specimen removed during the operation. Then the two adjacent tissue plane layers are connected with a cylindrical medical module. This operation is repeated to the height (z), and the spliced ​​human tissue scaffold structure is implanted into the surgical cavity after resection, drainage is placed, and the wound is closed layer by layer.

[0025] The medical module material is medical metal or medical silicone material, or it can be a degradable biomaterial, including one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-hydroxyacetic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer. It has excellent biodegradability and can be gradually absorbed by the body after surgery, avoiding long-term residual foreign body reactions in the body and promoting the patient's postoperative recovery. Example 2

[0026] See also Figure 3 , perform the resection surgery according to the scope of preoperative clinical examination and imaging evaluation, and then measure the resected specimen to obtain the length (x), width (y), and height (z) of the specimen. According to the measurement results, select rectangular medical modules, T-shaped modules, L-shaped modules, and cross-shaped modules for splicing human tissue scaffolds.

[0027] See also Fig. 9 , 10 , 11, 12, 13, 14, 15, 16, the medical modules of the human tissue scaffold are rectangular modules, T-shaped modules, L-shaped modules, and cross-shaped modules, and the particle height is 0.5 cm. The medical modules can be spliced ​​into the required shape according to the actual needs of the operation.

[0028] See also Fig. 9 , 10 , 11, 12, 13, 14, 15, 16, a plurality of protrusions are arranged on one side of the rectangular module, the T-shaped module, the L-shaped module, and the cross-shaped module, the height of the protrusions is 0.2 cm, and a plurality of recesses are arranged on the other side perpendicular to the protrusions, the depth of the recesses is 0.2 cm, and during the operation, the protrusions and the recesses can be combined by mutual plugging to form a tissue component.

[0029] See also Figure 6 During the operation, the rectangular modules, T-shaped modules, L-shaped modules, and cross-shaped modules are repeatedly spliced ​​according to the actual situation of the patient, and they are spliced ​​into multiple tissue components, and then the tissue components are gradually spliced ​​into tissue plane layers; See also Figure 3 , repeatedly splice multiple tissue plane layers, the length (x) and width (y) parameters of each tissue plane layer are the same as the length (x) and width (y) parameters of the corresponding layer of the specimen removed during surgery, and then plug the two adjacent tissue plane layers into each other, repeat this operation to the height (z), implant the spliced ​​human tissue scaffold structure into the surgical cavity after resection, place drainage, and close the wound layer by layer.

[0030] The medical module material is medical metal or medical silicone material, or it can be a degradable biomaterial, including one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-hydroxyacetic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer. It has excellent biodegradability and can be gradually absorbed by the body after surgery, avoiding long-term residual foreign body reactions in the body and promoting the patient's postoperative recovery.

Claims

1. A human tissue scaffold (1, 13) composed of medical modules, characterized in that: The human tissue scaffold (1, 13) spliced ​​by medical modules is composed of scaffold components (2, 14) spliced ​​together, and can flexibly and accurately fill the tissue area according to the actual morphology of the excised tissue, thereby optimizing the postoperative recovery effect.

2. The human tissue scaffold composed of medical modules according to claim 1, characterized in that: The support assembly (2) is formed by splicing a connector module (4) and a columnar module (5).

3. The human tissue scaffold composed of medical modules according to claim 1, characterized in that: The support assembly (14) is formed by splicing a rectangular module (7), a T-shaped module (8), an L-shaped module (9), and a cross-shaped module (10).

4. The human tissue scaffold composed of medical modules according to claim 2, characterized in that: The surface of the connector module (4) is provided with a socket (3), and a plurality of columnar modules (5) and the socket (3) can be combined in a mutually plugged manner.

5. The human tissue scaffold composed of medical modules according to claim 4, characterized in that: The socket (3) can accurately fit one end of the columnar module (5), and the connector module (4) and the columnar module (5) can be spliced ​​during surgery according to the actual required quantity and volume shape of the resected tissue.

6. The human tissue scaffold composed of medical modules according to claim 3, characterized in that: A plurality of protrusions (11) are provided on one side of the rectangular module (7), T-shaped module (8), L-shaped module (9), and cross-shaped module (10), and a plurality of recesses (12) are provided on the other side vertically symmetrical to the protrusions (11); the protrusions (11) and the recesses (12) can be combined by plugging into each other.

7. The human tissue scaffold composed of medical modules according to claim 6, characterized in that: The rectangular module (7), T-shaped module (8), L-shaped module (9), and cross-shaped module (10) have mutually adapted lengths, widths, and heights, and can be spliced ​​together during surgery according to the actual required number and volume of the resected tissue.

8. The human tissue scaffold assembled by medical modules according to any one of claims 1 to 7, characterized in that: The medical module is made of medical metal or medical silicone material.

9. The human tissue scaffold assembled by medical modules according to any one of claims 1 to 7, characterized in that: The human tissue scaffold (1, 13) spliced ​​by medical modules is a high molecular biomaterial that can be degraded in the human body.

10. The human tissue scaffold composed of medical modules according to claim 9, characterized in that: The polymer biomaterial of the human tissue scaffold (1, 13) spliced ​​by the medical modules is one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-hydroxyacetic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer.

11. The human tissue scaffold assembled by medical modules according to claim 2 or 3, characterized in that: Titanium clips (6) are embedded inside the connector module (4) and the cross-shaped module (10), and the position and number of the titanium clips (6) can be flexibly adjusted according to the specific morphology of the tissue during surgery and the size of the residual cavity, thereby ensuring accurate positioning of postoperative radiotherapy.

12. The method for splicing a human tissue scaffold by splicing medical modules according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1. Perform resection surgery according to the scope of preoperative clinical examination and imaging evaluation; S2. Measure the length (x), width (y), and height (z) of the resected specimen or surgical cavity; S3. Assemble different medical modules into the required stent assembly according to the actual needs of the patient; S4. Repeat step 3 to make multiple scaffold components, and splice the multiple scaffold components into a tissue plane layer; S5. Repeat steps 3 and 4 to splice multiple tissue plane layers, and the length (x) and width (y) of each tissue plane layer are the same as the length (x) and width (y) of the resected specimen; S6. Connect different tissue plane layers using modules, and repeat this operation until the height of z is reached to gradually assemble them into a modular human tissue scaffold.

Images