Amber-containing traditional Chinese medicine preparation capable of relieving encephalatrophy and preparation method thereof

Abstract

The invention discloses an amber-containing traditional Chinese medicine preparation capable of relieving encephalatrophy and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from, by weight, 5-15 parts of amber, 5-15 parts of hawthorn leaves, 10-20 parts of tortoise shells, 15-25 parts of cornu cervi degelatinatum, 6-10 parts of rhizoma cimicifugae, 10-15 parts of radix curcumae, 6-10 parts of radix angelicae, 10-18 parts of tabasheer, 1-10 parts of arisaema cum bile, 5-15 parts of rhodomyrtus tomentosa roots, 2-8 parts of rhizoma nardostachyos, 2-8 parts of benzoin and 5-10 parts of semen cuscutae. The traditional Chinese medicine preparation disclosed by the invention has the effects of relieving encephalatrophy, delaying dementia and improving clinical symptoms, and is good in treatment effect, quick to take effect, definite in curative effect and free from toxic and side effects.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and in particular to a traditional Chinese medicine preparation containing amber and capable of alleviating brain atrophy, and a preparation method thereof. Background Art

[0002] Brain atrophy is a brain disease named after pathological changes. Modern medicine believes that brain atrophy mainly refers to the reduction of brain tissue structure volume, the decrease of cell number, mild gliosis and different degrees of degenerative lesions of cerebral arteries. Clinical manifestations are clinical syndromes of severe cognitive deficits or decline, such as progressive thinking, memory, behavior and personality disorders, which may be accompanied by symptoms of mental and motor dysfunction, and damage and affect occupational, social functions or living ability.

[0003] Although there is no disease name of "brain atrophy" in traditional Chinese medicine, discussions related to brain atrophy can be found in dementia, fatigue, depression, amnesia, dizziness, etc. The key pathological factors of brain atrophy are deficiency and stasis, which can be defined as brain atrophy in traditional Chinese medicine; its pathogenesis is mainly due to deficiency of qi, blood, yin and essence in the internal organs, stasis in the blood vessels leading to insufficient upward transport and loss of filling of the marrow sea.

[0004] At present, there is no specific medicine for the treatment of cerebral atrophy in Western medicine. Only Western medicine with early control or prevention and relief effects can be taken, but Western medicine has great side effects, single efficacy, and only treats the symptoms but not the root cause. Traditional Chinese medicine treatment has the characteristics of treating both the symptoms and the root cause. Based on this, it is very meaningful to develop a Chinese medicine preparation with fast effect, good efficacy and no toxic side effects to relieve cerebral atrophy. Summary of the invention

[0005] In view of the above problems, the present invention provides a Chinese medicine preparation containing amber and capable of alleviating cerebral atrophy and a preparation method thereof, thereby solving the problems in the prior art that Chinese and Western medicines have large side effects, single efficacy, and only treat the symptoms but not the root cause.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is as follows: The invention provides a traditional Chinese medicine preparation containing amber and capable of alleviating brain atrophy. The traditional Chinese medicine preparation is composed of the following raw materials in parts by weight: 5-15 parts of amber, 5-15 parts of hawthorn leaves, 10-20 parts of tortoise shells, 15-25 parts of antler frost, 6-10 parts of cimicifuga, 10-15 parts of curcuma, 6-10 parts of angelica dahurica, 10-18 parts of rhizoma jasminoides, 1-10 parts of arisaema cinerea, 5-15 parts of rhizoma schoenoprasum, 2-8 parts of nardostachys grandiflora, 2-8 parts of benzoin and 5-10 parts of dodder seeds.

[0007] Furthermore, the Chinese medicine preparation is composed of the following raw materials in parts by weight: 10 parts of amber, 10 parts of hawthorn leaves, 15 parts of tortoise shells, 20 parts of antler frost, 8 parts of cimicifuga, 12 parts of curcuma, 8 parts of angelica dahurica, 15 parts of gardenia, 5 parts of arisaema, 10 parts of rhizoma schoenoprasum, 5 parts of nardostachys grandiflora, 5 parts of benzoin, and 8 parts of dodder seeds.

[0008] The present invention also provides a method for preparing a Chinese medicine preparation containing amber that can alleviate brain atrophy, which specifically comprises the following steps: S1: Mix amber, hawthorn leaves, tortoise shell, antler frost, cimicifuga, curcuma, angelica dahurica, rhizoma dahliae, smilax china, rhizoma strychnifoliae, rhizoma sutchuenensis, rhizoma sutchuenensis, rhizoma sutchuenensis, benzoin and dodder seed according to weight proportions, grind and sieve to obtain Chinese medicine powder; S2: adding water to the Chinese medicine powder, soaking, boiling and extracting, filtering, and obtaining a filtrate; repeating the extraction three times, combining the filtrates, obtaining a drug extract, and concentrating the drug extract by reduced pressure evaporation to obtain a drug paste; S3: adding pharmaceutically acceptable excipients to the thick paste, mixing evenly, to prepare the traditional Chinese medicine preparation.

[0009] Furthermore, in step S1, the number of sieving is 20-40 meshes.

[0010] Furthermore, in step S2, the mass ratio of Chinese medicine powder to water is 1:10-15; the soaking time is 1.5-2.5 hours, the extraction time is 2.5-3.5 hours; the concentration temperature is 55°C; and the relative density of the thick paste is 1.22-1.28 g / mL.

[0011] Furthermore, in step S3, the dosage form of the Chinese medicine preparation is tablets, pills or granules.

[0012] Brain atrophy belongs to the category of "brain marrow consumption" in traditional Chinese medicine. From the perspective of traditional Chinese medicine, the kidney qi of the elderly gradually declines, the yin essence is depleted, the marrow cannot be produced to fill the brain, the soul is not nourished, and the brain marrow is consumed, leading to brain atrophy. At the same time, the spleen of the elderly fails to function properly, phlegm is generated internally, obscuring the clear orifices, qi deficiency and blood stasis, brain collaterals are blocked, and phlegm and blood stasis damage the brain nerves, just like clouds covering the sunset, the sun is not bright, and the spirit is not used, resulting in a series of manifestations of brain function decline and intellectual impairment. Combined with the etiology and pathology of Western medicine, brain atrophy often coexists with pathological morphological changes such as lacunar cerebral infarction and demyelination of white matter. At this time, simply replenishing the kidney and filling the essence to replenish the brain marrow has certain limitations. Aiming at the pathological characteristics of senile brain atrophy, the Chinese medicine preparation containing amber that can relieve brain atrophy according to the theory of "monarch, minister, assistant and messenger" compatibility uses tortoise shell, antler frost, curcuma, and rhizoma jasminoides as monarch medicines, which have the effects of warming the kidney and assisting yang, clearing away heat and removing phlegm, and cooling the heart and calming the nerves; uses amber, hawthorn leaves, cimicifuga, benzoin, and dodder seeds as minister medicines, which have the effects of clearing away heat and detoxifying, calming the nerves and tranquilizing the mind, regulating qi and unblocking meridians, opening the mind and invigorating the kidney and replenishing essence; uses angelica dahurica, arisaema ciliata, rhizoma strychnifoliae, rhizoma serratae, and liquorice as assistant and messenger medicines, which have the effects of clearing heat and removing phlegm, soothing the liver and unblocking the meridians, relieving depression and invigorating the spleen, and harmonizing the properties of the medicine. After clinical verification, this prescription has the effects of alleviating brain atrophy, delaying dementia, and improving clinical symptoms.

[0013] The pharmacological effects of the above-mentioned Chinese medicine raw materials are as follows: Turtle shell: slightly cold in nature, salty and sweet in taste. Enters the liver meridian, kidney meridian, and heart meridian. It has the effects of nourishing yin and suppressing yang, benefiting the kidney and strengthening bones, nourishing blood and nourishing the heart. It is used for yin deficiency, hot flashes, bone steaming and night sweats, dizziness, internal wind movement, weakness of tendons and bones, and forgetfulness due to heart deficiency.

[0014] Deer antler frost: salty, astringent, warm. Enters the liver and kidney meridians. Has the effects of warming the kidney and supporting yang, astringing and stopping bleeding. Used for spleen and kidney yang deficiency, excessive leucorrhea, enuresis and frequent urination, metrorrhagia, and sores that do not heal.

[0015] Curcuma: pungent, bitter, cold. Enters the liver, heart, and lung meridians. It has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood, promoting bile and relieving jaundice. It is used for chest and flank pain, chest obstruction and heart pain, amenorrhea and dysmenorrhea, breast pain, febrile coma, epilepsy, vomiting and bleeding due to blood heat, and jaundice and red urine.

[0016] Tianzhuhuang: cold in nature, sweet in taste. It enters the heart meridian and liver meridian. It has the effects of clearing away heat and dispelling phlegm, cooling the heart and calming the nerves. It is used to treat fever, coma, stroke, phlegm, phlegm-heat convulsions, convulsions, and night crying in children.

[0017] Amber: neutral in nature, sweet in taste. It enters the heart meridian, liver meridian, and bladder meridian. It has the effects of calming the nerves, dispersing blood stasis and stopping bleeding, promoting diuresis and relieving stranguria, and removing cataracts and improving eyesight. It is used to treat insomnia, palpitations, convulsions, epilepsy, amenorrhea due to blood stasis, abdominal pain after childbirth, accumulation of masses, blood in the urine, and cataracts.

[0018] Hawthorn leaf: neutral in nature, sour in taste. Enters the liver meridian. Has the effects of promoting blood circulation and removing blood stasis, regulating qi and unblocking meridians, removing turbidity and reducing lipids. It is used for qi stagnation and blood stasis, chest pain, chest tightness and shortness of breath, palpitations and forgetfulness, dizziness and tinnitus, and hyperlipidemia.

[0019] Cimicifuga: slightly cold in nature, pungent in taste, slightly sweet. It enters the lung meridian, spleen meridian, stomach meridian, and large intestine meridian. It has the effects of relieving rashes, clearing away heat and detoxifying, and raising Yang Qi. It is used to treat wind-heat headaches, toothaches, mouth sores, sore throats, measles that do not break out, Yang poison spots, rectal prolapse, uterine prolapse, etc.

[0020] Benzoin: neutral in nature, pungent and bitter in taste. It enters the heart meridian and spleen meridian. It has the effects of opening the orifices and clearing the mind, promoting qi, activating blood circulation, and relieving pain. It is used to treat stroke, phlegm syncope, qi stagnation, coma, heart and abdomen pain, postpartum blood fainting, and infantile convulsions.

[0021] Cuscuta: neutral in nature, pungent and sweet in taste. It enters the liver meridian, kidney meridian, and spleen meridian. It has the effects of nourishing the kidney and replenishing essence, nourishing the liver and improving eyesight. It is used for kidney deficiency and low back pain, impotence, premature ejaculation, turbid urine, leucorrhea, frequent urination; restless fetus, threatened abortion; liver and kidney deficiency, blurred vision, and decreased vision.

[0022] Angelica dahurica: warm in nature, pungent in taste. Enters the stomach meridian, large intestine meridian, and lung meridian. It has the effects of dispersing wind and dampness, clearing the orifices and relieving pain, and reducing swelling and draining pus. It is used to treat colds, headaches, brow pain, nasal congestion, sinusitis, toothache, leucorrhea, and sores and swelling.

[0023] Arisaema: Cool in nature, bitter and slightly pungent in taste. Enters the lung, liver and spleen meridians. Has the effects of clearing away heat and resolving phlegm, calming wind and calming convulsions. Used to treat phlegm-heat cough, yellow and thick phlegm, stroke and epilepsy.

[0024] Root of Ganoderma lucidum: It is mild in nature, sweet and slightly astringent in taste. It enters the liver meridian and kidney meridian. It has the effects of soothing the liver and dredging the meridians, and relieving pain. It is used to treat chest and flank pain caused by liver qi stagnation, rheumatic bone pain, and lumbar muscle strain.

[0025] Nardostachys grandiflora: warm in nature, pungent and sweet in taste. It enters the spleen and stomach meridians. It has the effects of regulating qi and relieving pain, relieving depression and invigorating the spleen. It is used to treat abdominal distension, loss of appetite, vomiting, and external treatment of toothache and swollen feet. It can also be used to treat neurasthenia, hysteria, insomnia, and fright.

[0026] Licorice: It is mild in nature, sweet in taste, and enters the heart meridian, stomach meridian, spleen meridian, and lung meridian. It has the effects of tonifying the spleen and replenishing qi, relieving cough and expectoration, relieving pain, and harmonizing the properties of medicines.

[0027] Compared with the prior art, the present invention has the following beneficial effects: In the present invention, by adopting Chinese medicines with the functions of nourishing the kidney, replenishing essence and nourishing marrow, resolving phlegm, invigorating the brain and opening the orifices, clearing away heat, detoxifying and unblocking meridians as raw materials, according to the Chinese medicine compatibility theory of "monarch, minister, assistant and messenger", a Chinese medicine preparation containing amber that can relieve brain atrophy is prepared, and the formula is reasonable; the Chinese medicine preparation of the present invention has the functions of relieving brain atrophy, delaying dementia, and improving clinical symptoms, has good therapeutic effect, is quick in effect, has definite therapeutic effect, and has no toxic side effects. DETAILED DESCRIPTION

[0028] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0029] The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are all conventional instruments, reagents, materials, etc. in the prior art and can be obtained through regular commercial channels. The experimental methods, detection methods, etc. involved in the following examples, unless otherwise specified, are all conventional experimental methods, detection methods, etc. in the prior art.

[0030] Example 1 The present embodiment provides a traditional Chinese medicine preparation containing amber that can relieve brain atrophy, which is composed of the following raw materials in parts by weight: 5 parts of amber, 5 parts of hawthorn leaves, 10 parts of tortoise shells, 15 parts of antler frost, 6 parts of cimicifuga, 10 parts of curcuma, 6 parts of angelica dahurica, 10 parts of rhizoma jasminoides, 1 part of arisaema, 5 parts of rhizoma schoenoprasum, 2 parts of nardostachys grandiflora, 2 parts of benzoin, and 5 parts of dodder seeds.

[0031] The preparation method of the traditional Chinese medicine preparation specifically comprises the following steps: S1: Mix amber, hawthorn leaves, tortoise shell, antler frost, cimicifuga, curcuma, angelica dahurica, rhizoma dahliae, smilax china, rhizoma strychnifoliae, rhizoma sutchuenensis ... benzoin and dodder seed according to weight proportions, and grind through a 20-mesh sieve to obtain a Chinese medicine powder; S2: Add 10 times of water to the Chinese medicine powder, soak for 1.5 hours, boil and extract for 2.5 hours, filter to obtain a filtrate; repeat the extraction 3 times, combine the filtrates to obtain a drug extract, evaporate and concentrate the drug extract at 55°C under reduced pressure to obtain a drug paste with a relative density of 1.22 g / mL; S3: Add pharmaceutically acceptable excipients to the thick paste, mix well, and prepare a tablet Chinese medicine preparation.

[0032] Example 2 The present embodiment provides a traditional Chinese medicine preparation containing amber that can relieve brain atrophy, which is composed of the following raw materials in parts by weight: 10 parts of amber, 10 parts of hawthorn leaves, 15 parts of tortoise shells, 20 parts of antler frost, 8 parts of cimicifuga, 12 parts of curcuma, 8 parts of angelica dahurica, 15 parts of gardenia, 5 parts of arisaema, 10 parts of rhizoma schoenoprasum, 5 parts of nardostachys grandiflora, 5 parts of benzoin, and 8 parts of dodder seeds.

[0033] The preparation method of the traditional Chinese medicine preparation specifically comprises the following steps: S1: Mix amber, hawthorn leaves, tortoise shell, antler frost, cimicifuga, curcuma, angelica dahurica, rhizoma dahliae, smilax china, rhizoma strychnifoliae, rhizoma sutchuenensis ... benzoin and dodder seed according to weight proportions, and grind through a 30-mesh sieve to obtain a Chinese medicine powder; S2: Add 12 times of water to the Chinese medicine powder, soak for 2 hours, boil and extract for 3 hours, filter to obtain a filtrate; repeat the extraction 3 times, combine the filtrates to obtain a drug extract, evaporate and concentrate the drug extract at 55°C under reduced pressure to obtain a drug paste with a relative density of 1.25 g / mL; S3: Add pharmaceutically acceptable excipients to the thick paste, mix well, and prepare a pill-shaped Chinese medicine preparation.

[0034] Example 3 The present embodiment provides a traditional Chinese medicine preparation containing amber that can relieve brain atrophy, which is composed of the following raw materials in parts by weight: 15 parts of amber, 15 parts of hawthorn leaves, 20 parts of tortoise shells, 25 parts of antler frost, 10 parts of cimicifuga, 15 parts of curcuma, 10 parts of angelica dahurica, 18 parts of gardenia, 10 parts of arisaema, 15 parts of rhizoma schoenoprasum, 8 parts of nardostachys grandiflora, 8 parts of benzoin, and 10 parts of dodder seeds.

[0035] The preparation method of the traditional Chinese medicine preparation specifically comprises the following steps: S1: Mix amber, hawthorn leaves, tortoise shell, antler frost, cimicifuga, turmeric, angelica dahurica, rhizoma dahliae, strychnos nux vomica, rhizoma strychnos, rhizoma serratae, rhizoma serratae, rhizoma serratae, benzoin, and dodder seed according to weight, and grind through a 40-mesh sieve to obtain a Chinese medicine powder; S2: Add 15 times of water to the Chinese medicine powder, soak for 2.5 hours, boil and extract for 3.5 hours, filter to obtain a filtrate; repeat the extraction 3 times, combine the filtrates to obtain a drug extract, evaporate and concentrate the drug extract at 55°C under reduced pressure to obtain a drug paste with a relative density of 1.28 g / mL; S3: Add pharmaceutically acceptable excipients to the thick paste, mix well, and prepare a granular Chinese medicine preparation.

[0036] The clinical efficacy of the Chinese medicine preparation prepared in the above examples is observed as follows: 1. Clinical data and methods: 60 patients with cerebral atrophy admitted to our hospital from January 2022 to August 2023 were selected. All samples had clinical manifestations such as dizziness, headache, insomnia, amnesia, tremor, slow reaction, soreness of waist and knees, numbness, dementia, intellectual decline and memory impairment, which met the clinical diagnostic criteria for cerebral atrophy. The samples were randomly divided into treatment group 1, treatment group 2, treatment group 3 and control group, with 15 cases in each group. There were 9 males and 6 females in treatment group 1, with an average age of (65±2.3) years old; there were 8 males and 7 females in treatment group 2, with an average age of (63±3.4) years old; there were 9 males and 6 females in treatment group 3, with an average age of (64±3.5) years old; there were 10 males and 5 females in the control group, with an average age of (64±2.9) years old. There was no statistical difference in the age and clinical data of the subjects in the four groups, and they were comparable.

[0037] 2. Treatment method: Treatment groups 1-3 took the Chinese medicine preparations prepared in Examples 1-3 (10 g / time, 2 times / d, washed with appropriate amount of warm water). The control group selected piracetam injection, intramuscular injection 1 g / time, 2 times / d; Citicoline injection, 0.2 g of the drug was injected into 5% glucose injection for intravenous drip, 1 time / d; and Thromboton injection, 5 mL was injected into 10% glucose injection for intravenous drip, 1 time / d. The two groups were treated with the above methods, 7 days as a course of treatment, and 4 courses of treatment were continued.

[0038] 3. Efficacy standards Significant effect: Clinical symptoms such as dizziness, headache, insomnia disappeared, and memory and intelligence levels improved; Effective: Clinical symptoms such as dizziness, headache, and insomnia improved, and memory and intelligence levels partially improved; Ineffective: All clinical symptoms were not improved or even aggravated.

[0039] Total effective rate = significant effect + effective.

[0040] Table 1 Comparison of efficacy

[0041] From the results in Table 1, it can be seen that the total effective rates of treatment groups 1-3 were 86.7%-93.3%, which were significantly better than those of the control group. Based on this, the Chinese medicine preparation prepared in this embodiment has a significant therapeutic effect on relieving cerebral atrophy, has a definite therapeutic effect, is effective quickly, and has no toxic side effects.

[0042] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine preparation containing amber that can alleviate brain atrophy, characterized in that: The Chinese medicine preparation is composed of the following raw materials in parts by weight: 5-15 parts of amber, 5-15 parts of hawthorn leaves, 10-20 parts of tortoise shells, 15-25 parts of antler frost, 6-10 parts of cimicifuga, 10-15 parts of curcuma, 6-10 parts of angelica dahurica, 10-18 parts of rhizoma jasminoides, 1-10 parts of gentiana bile, 5-15 parts of rhizoma schoenoprasum, 2-8 parts of nardostachys grandiflora, 2-8 parts of benzoin, and 5-10 parts of dodder seeds.

2. A Chinese medicine preparation containing amber capable of alleviating brain atrophy according to claim 1, characterized in that: The Chinese medicine preparation is composed of the following raw materials in parts by weight: 10 parts of amber, 10 parts of hawthorn leaves, 15 parts of tortoise shells, 20 parts of antler frost, 8 parts of cimicifuga, 12 parts of curcuma, 8 parts of angelica dahurica, 15 parts of rhizoma jasminoides, 5 parts of gentiana bile, 10 parts of rhizoma schoenoprasum, 5 parts of nardostachys grandiflora, 5 parts of benzoin, and 8 parts of dodder seeds.

3. A method for preparing a Chinese medicine preparation containing amber capable of alleviating brain atrophy as claimed in any one of claims 1 to 2, characterized in that: The specific steps include: S1: Mix amber, hawthorn leaves, tortoise shell, antler frost, cimicifuga, curcuma, angelica dahurica, rhizoma dahliae, smilax china, rhizoma strychnifoliae, rhizoma sutchuenensis, rhizoma sutchuenensis, rhizoma sutchuenensis, benzoin and dodder seed according to weight proportions, grind and sieve to obtain Chinese medicine powder; S2: adding water to the Chinese medicine powder, soaking, boiling and extracting, filtering, and obtaining a filtrate; repeating the extraction three times, combining the filtrates, obtaining a drug extract, and concentrating the drug extract by reduced pressure evaporation to obtain a drug paste; S3: adding pharmaceutically acceptable excipients to the thick paste, mixing evenly, to prepare the traditional Chinese medicine preparation.

4. A method for preparing a Chinese medicine preparation containing amber capable of alleviating brain atrophy according to claim 3, characterized in that: In the step S1, the number of sieving is 20-40 meshes.

5. The method for preparing a Chinese medicine preparation containing amber capable of alleviating brain atrophy according to claim 3, characterized in that: In the step S2, the mass ratio of the Chinese medicine powder to water is 1:10-15; the soaking time is 1.5-2.5 hours, the extraction time is 2.5-3.5 hours; the concentration temperature is 55° C.; and the relative density of the thick paste is 1.22-1.28 g / mL.

6. The method for preparing a Chinese medicinal preparation containing amber capable of alleviating brain atrophy according to claim 3, characterized in that: In step S3, the dosage form of the Chinese medicine preparation is tablets, pills or granules.

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