Intermittent high-oxygen system

Abstract

The invention relates to the technical field of medical equipment, in particular to an intermittent high-oxygen system. The intermittent hyperoxia system provided by the invention can monitor the oxygen concentration, temperature, humidity, pressure and other environmental parameters in the hyperoxia cabin in real time, has alarm and automatic correction functions, can ensure the safety in the hyperoxia treatment process, and avoids the harm to a testee due to the fact that the parameters exceed a set range. The intermittent hyperoxia system can be used for intermittent hyperoxia intervention in the acute stage of ischemic brain injury and other types of brain injury, can effectively improve the neurological function and reduce the cerebral infarction volume, and has important application value and market prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to an intermittent hyperoxia system. Background Art

[0002] Ischemic stroke is the most common type of stroke, which is mainly caused by acute interruption of cerebral blood flow, leading to neuronal necrosis and brain tissue damage. In the acute phase of stroke, timely restoration of cerebral blood flow, protection of neurons and reduction of secondary damage are key. At present, thrombolysis and mechanical thrombectomy techniques are mainly used clinically to restore local blood perfusion, but this type of intervention has indications and time window limitations and cannot cover all patients. At the same time, the inflammatory response and oxidative stress associated with brain tissue ischemia and reperfusion in the acute phase of stroke further aggravate brain damage, and existing treatments have limited effect in alleviating this series of pathological processes.

[0003] Oxygen therapy has gradually attracted attention as a potential auxiliary intervention in neuroprotection. Although traditional continuous hyperoxia therapy can temporarily increase tissue oxygen supply, it is easy to cause oxygen poisoning and excessive oxidative stress, and even aggravate brain damage. In contrast, intermittent hyperoxia can not only relieve the hypoxic state through periodic changes in oxygen supply, but also reduce the side effects of continuous hyperoxia. Therefore, intermittent hyperoxia intervention in the acute stage of ischemic brain injury has become an effective intervention method.

[0004] Therefore, it is of great significance to provide an intermittent hyperoxia system. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides an intermittent hyperoxia system that can monitor the environmental parameters such as oxygen concentration, temperature, humidity, pressure, etc. in the hyperoxia chamber in real time, and has alarm and automatic correction functions, which can ensure the safety during hyperoxia treatment and avoid harm to the test subject due to parameters exceeding the set range. The intermittent hyperoxia system of the present invention can be used for intermittent hyperoxia intervention in the acute stage of ischemic brain injury and other types of brain injury, which can effectively improve neurological function and reduce cerebral infarction volume, and has important application value and market prospects.

[0006] In a first aspect, the present invention provides an intermittent hyperoxia system, the intermittent hyperoxia system comprising a power module, a control module, a hyperoxia generating module and a display module;

[0007] The hyperoxia generating module comprises an oxygen supply module, a nitrogen supply module, a carbon dioxide supply module, an air inlet, a valve control module, a gas flow control module, a gas mixing module, an air outlet and a hyperoxia chamber;

[0008] The oxygen supply module is used to provide oxygen required by the hyperoxia cabin, the nitrogen supply module is used to provide nitrogen required by the hyperoxia cabin, the carbon dioxide supply module is used to provide carbon dioxide required by the hyperoxia cabin, the valve control module is used to control the valve switches of the oxygen supply module, the nitrogen supply module and the carbon dioxide supply module, the gas inlet is used to allow the gases in the oxygen supply module, the nitrogen supply module and the carbon dioxide supply module to enter the gas mixing module, the gas flow control module is used to control the flow of the gas, the gas mixing module is used to mix the gases, and the gas outlet is used to allow the mixed gas in the gas mixing module to enter the hyperoxia cabin;

[0009] The power module is used to supply power to the intermittent hyperoxia system;

[0010] The control module is used to control the environmental parameters in the hyperoxia chamber, including target values ​​and fluctuation ranges of parameters such as oxygen concentration, nitrogen concentration, carbon dioxide concentration, temperature, humidity, pressure, and brightness;

[0011] The display module is used to display the environmental parameters in the hyperoxia chamber, including oxygen concentration, nitrogen concentration, carbon dioxide concentration, temperature, humidity, pressure, etc. and the progress of intermittent hyperoxia, and at the same time display the status of the test subject in the hyperoxia chamber in real time to improve the safety of the system.

[0012] As a preferred technical solution of the present invention, the hyperoxia cabin is provided with a brightness module, a detection module and an observation module;

[0013] The brightness module is used to control the switch, light effect and light intensity of the lights in the hyperoxia chamber;

[0014] The detection module is used to detect the environmental parameters in the hyperoxia chamber and transmit the data to the display module for real-time display, and transmit the data to the control module to determine whether the environment in the hyperoxia chamber is normal;

[0015] The observation module is used to observe the status of the test subject in the hyperoxia chamber in real time and transmit the data to the display module.

[0016] As a preferred technical solution of the present invention, the control module includes a setting module, an alarm module and a correction module;

[0017] The setting module is used to set the environmental parameters in the hyperoxia chamber, including target values ​​and fluctuation ranges of parameters such as oxygen concentration, nitrogen concentration, carbon dioxide concentration, temperature, humidity, pressure, and brightness;

[0018] The alarm module is used to alarm when the environmental parameters displayed by the display module exceed the environmental parameter range set by the setting module;

[0019] The correction module is used to perform correction when the environmental parameters displayed by the display module deviate from the environmental parameters set by the setting module; after the correction module performs correction, if the environmental parameters return to normal, intermittent hyperoxia continues; if the environmental parameters cannot return to normal, that is, correction cannot be performed (for example, the oxygen concentration exceeds or falls below the set threshold), the alarm system is activated to terminate the intermittent hyperoxia in advance or decide whether to continue the hyperoxia according to the state of the test subject or the specific experimental progress.

[0020] As a preferred technical solution of the present invention, the oxygen content in the hyperoxic chamber is 21-40%, wherein the oxygen content in the hyperoxic state is 33-40%, preferably 33%, and the oxygen content in the normoxic state is 21%. The hyperoxic state and the normoxic state last for 5-10 minutes (e.g., 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, etc., preferably 5 minutes) for a hyperoxic-normoxic cycle, and the intermittent hyperoxic state is to maintain the normoxic state after 5-15 (e.g., 5, 8, 10, 12 or 15, etc., preferably 10) hyperoxic-normoxic cycles within 24 hours. That is to say, preferably, within 24 hours, the interval between hyperoxic and normoxic is 5 minutes, the frequency is 10 cycles, a total of about 2-3 hours of hyperoxic state, and 21-22 hours of normoxic state.

[0021] As a preferred technical solution of the present invention, the oxygen content in the hyperoxia chamber is 21-33%.

[0022] As a preferred technical solution of the present invention, the intermittent hyperoxia state is set for 3 days.

[0023] The intermittent hyperoxia system provided by the present invention is used to perform intermittent hyperoxia intervention on animals with neurological dysfunction caused by ischemic brain injury (such as mice, rats, rabbits, etc.), and the oxygen concentration in the cabin and the activity status of the animals can be observed in real time. At the same time, the present invention adjusts and optimizes parameters such as the hyperoxia concentration, duration, interval time and alternating frequency of the intermittent hyperoxia state. After 3 days of intervention in the above-mentioned intermittent hyperoxia state, the brain-injured animals can effectively improve neurological function, reduce infarction volume, and increase cerebral blood flow, especially in terms of neurological function recovery and infarction volume reduction.

[0024] It is understandable that the ischemic brain injury includes acute ischemic stroke, traumatic brain injury (TBI), ischemic optic neuropathy, neurodegenerative diseases, etc. In these diseases, limited oxygen supply and oxidative stress response of brain tissue are often important links in the development of pathology. Intermittent hyperoxia therapy can improve oxygen supply, reduce oxidative damage, and promote neurological function recovery and tissue repair. The parameters such as high oxygen concentration, duration, interval time and alternating frequency of the intermittent hyperoxia state can be adjusted according to actual needs. For example, the intervention effect of different parameters on acute brain injury can be evaluated by adjusting the oxygen content (such as 33%-40%) in the hyperoxia state or extending the duration of treatment. For stroke patients at different pathological stages, the oxygen supply mode can also be adjusted (such as increasing or decreasing the duration of hyperoxia, shortening the interval time of normoxia, etc.) to achieve personalized treatment. In addition, other treatment methods can be combined, such as drug intervention, gene therapy or biomarker monitoring to improve the treatment effect.

[0025] As a preferred technical solution of the present invention, the temperature in the hyperoxia chamber is 22-25°C, for example, 22°C, 23°C, 24°C, 25°C, etc.; the humidity is 40-60%, for example, 40%, 45%, 50%, 55%, 60%, etc.; the pressure is 100-110Kpa, for example, 102Kpa, 104Kpa, 106Kpa, 108Kpa, 110Kpa, etc.; the light intensity is natural light level 1.

[0026] As a preferred technical solution of the present invention, the gas flow control module sets the gas flow rate to 200-300mL / min, for example, 200mL / min, 220mL / min, 240mL / min, 260mL / min, 280mL / min, 300mL / min, etc.

[0027] The technical solution provided by the embodiment of the present invention has the following advantages compared with the prior art:

[0028] 1. The intermittent hyperoxia system provided by the present invention can monitor the environmental parameters such as oxygen concentration, temperature, humidity, pressure, etc. in the hyperoxia chamber in real time, and has alarm and automatic correction functions, which can ensure the safety during hyperoxia treatment and avoid harm to the test subject due to parameters exceeding the set range. In addition, the intermittent hyperoxia system of the present invention can be used for intermittent hyperoxia intervention in the acute stage of ischemic brain injury and other types of brain injury, which can effectively improve neurological function and reduce cerebral infarction volume, and has important application value and market prospects.

[0029] 2. The intermittent hyperoxia system provided by the present invention is used to perform intermittent hyperoxia intervention on animals with neurological dysfunction caused by ischemic brain damage, and by adjusting and optimizing parameters such as the high oxygen concentration, duration, interval time and alternating frequency of the intermittent hyperoxia state, it can effectively alleviate the hypoxic state, enhance the neuroprotective effect, and reduce adverse reactions, thereby avoiding the side effects of oxidative stress and oxygen poisoning caused by traditional continuous hyperoxia therapy.

[0030] 3. The intermittent hyperoxia system provided by the present invention can not only be used for the treatment of ischemic brain injury, but also can be extended to the field of chronic diseases and rehabilitation treatment. For example, patients with chronic hypoxia (such as chronic obstructive pulmonary disease, sleep apnea syndrome, etc.) can use the intermittent hyperoxia system of the present invention for intermittent hyperoxia treatment during the rehabilitation period or chronic stage to help restore the damaged nervous system function and improve the quality of life of patients. In addition, it can also be used in the research of tissue regeneration and repair, promote the development of regenerative medicine, especially in the fields of trauma repair, fracture healing, skin burns, etc., and has potential application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0032] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0033] Figure 1 This is a schematic diagram of the structure of the intermittent high oxygen system of Example 1 of the present invention.

[0034] Figure 2 This is a flow chart of the method for intermittent hyperoxia intervention in Example 2 of the present invention.

[0035] Figure 3 This is the intermittent high oxygen mode diagram of Example 2 of the present invention.

[0036] Figure 4 The figures are the results of the step-error rate of different groups of mice in the grid step-error experiment in Example 2 of the present invention.

[0037] Figure 5 The results of the touch time of the sticker removal experiment of different groups of mice in Example 2 of the present invention are shown.

[0038] Figure 6 The figures are the removal time results of the sticker removal experiment for different groups of mice in Example 2 of the present invention.

[0039] Figure 7 These are the MRI T2 evaluation results of cerebral infarction volume of mice in different groups according to Example 2 of the present invention.

[0040] Figure 8 These are the quantitative calculation results of cerebral infarction volumes in different groups of mice in Example 2 of the present invention.

[0041] Fig. 9 This is a diagram of cerebral blood flow of mice in different groups according to Example 2 of the present invention.

[0042] Fig.10 These are the quantitative results of cerebral blood flow of mice in different groups in Example 2 of the present invention. DETAILED DESCRIPTION

[0043] In order to more clearly understand the above-mentioned objectives, features and advantages of the present invention, the scheme of the present invention will be further described below. It should be noted that the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

[0044] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein; it is obvious that the embodiments in the specification are only part of the embodiments of the present invention, rather than all of the embodiments.

[0045] Example 1

[0046] This embodiment provides an intermittent high oxygen system, and its structural schematic diagram is as follows: Figure 1 As shown, the intermittent hyperoxia system includes a power module 1, a control module 2, a hyperoxia generating module 3 and a display module 4;

[0047] The hyperoxia generating module 3 includes an oxygen supply module 31, a nitrogen supply module 32, a carbon dioxide supply module 33, an air inlet 34, a valve control module 35, a gas flow control module 36, a gas mixing module 37, an air outlet 38 and a hyperoxia chamber 39; wherein the oxygen supply module 31 is used to provide the oxygen required by the hyperoxia chamber 39, the nitrogen supply module 32 is used to provide the nitrogen required by the hyperoxia chamber 39, the carbon dioxide supply module 33 is used to provide the carbon dioxide required by the hyperoxia chamber 39, the valve control module 35 is used to control the valve switches of the oxygen supply module 31, the nitrogen supply module 32 and the carbon dioxide supply module 33, the air inlet 34 is used to allow the gases in the oxygen supply module 31, the nitrogen supply module 32 and the carbon dioxide supply module 33 to enter the gas mixing module 37, the gas flow control module 36 is used to control the flow of the gas, and the gas flow is set to 200-30mL / min, the gas mixing module 37 is used to mix the gases, and the air outlet 38 is used to allow the mixed gas in the gas mixing module 37 to enter the hyperoxia chamber 39;

[0048] The hyperoxia chamber 39 is provided with a brightness module 391, a detection module 392 and an observation module 393; the brightness module 391 is used to control the switch of the light in the hyperoxia chamber 39 as well as the light efficiency and light intensity; the detection module 392 is used to detect the environmental parameters in the hyperoxia chamber 39 and transmit the data to the display module 4 for real-time display, and transmit the data to the control module 2 to determine whether the environment in the hyperoxia chamber 39 is normal; the observation module 393 is used to observe the state of the test subject in the hyperoxia chamber 39 in real time and transmit the data to the display module 4;

[0049] The power module 1 is used to supply power to the intermittent high oxygen system;

[0050] The control module 2 is used to control the environmental parameters in the hyperoxia chamber 39, and the control module 2 includes a setting module 21, an alarm module 22 and a correction module 23; the setting module 21 is used to set the environmental parameters in the hyperoxia chamber 39, the temperature is set to 22-25°C, the humidity is set to 40%-60%, the pressure is set to 100-110KPa, and the light intensity is set to natural light level 1; the alarm module 22 is used to alarm when the environmental parameters displayed by the display module 4 exceed the environmental parameter range set by the setting module 21; the correction module 23 is used to correct when the environmental parameters displayed by the display module 4 deviate from the environmental parameters set by the setting module 21, that is, when the environmental parameters exceed the range set by the setting module 21, the correction module 23 will be started, and if the environmental parameters of the hyperoxia chamber return to normal, hyperoxia will continue; if the hyperoxia chamber parameters cannot be corrected, the alarm module 22 will be started to end hyperoxia in advance; after hyperoxia ends, the valve control module 35 is automatically closed;

[0051] The display module 4 is used to display the environmental parameters in the hyperoxia chamber 39 .

[0052] Example 2

[0053] This example is used to explore the effect of the intermittent hyperoxia system of the present invention on ischemic stroke animals.

[0054] 1. Preparation of ischemic stroke animal model:

[0055] Forty 8-week-old mice were randomly divided into 4 groups. All animals were kept at room temperature (23±2°C) with a light / dark (12 / 12 h) cycle. Each mouse had free access to food and water.

[0056] In three groups, mice were first induced with 5% volume of isoflurane, and after the mice were fully anesthetized, anesthesia was maintained with 2% volume of isoflurane. The neck tissue was carefully separated, and the left common carotid artery was exposed and permanently ligated. After exposing the left distal branch of the middle cerebral artery through a small craniotomy, an electrocoagulator was used to permanently block the branch, taking care to avoid damaging surrounding tissues. The body temperature was maintained between 36.5-37.5°C during surgery. To confirm the occlusion of the distal middle cerebral artery, laser speckle was used to measure mouse cerebral blood flow before, during, and after surgery.

[0057] The model construction steps for another group were the same as above, except that the left common carotid artery was not ligated, the distal branches of the middle cerebral artery were not cauterized, and oxygen therapy was not performed, which served as the sham operation group.

[0058] Exclusion criteria: cerebral blood flow after modeling decreased by less than 30% compared with the baseline level; subarachnoid hemorrhage during surgery; surrounding tissue damage caused by electrocoagulation leading to massive bleeding.

[0059] 2. Grouping of animal models:

[0060] The three groups of mice except the sham operation group were randomly divided into intermittent hyperoxia group, continuous hyperoxia group and model group, among which:

[0061] Intermittent hyperoxia group: On the day after model preparation, as well as on the second and third days, the intermittent hyperoxia group was placed in the hyperoxia chamber of the intermittent hyperoxia system described in Example 1 for intermittent hyperoxia intervention. The flow chart of the intermittent hyperoxia intervention method is as follows: Figure 2 As shown, the oxygen concentration parameter settings are as follows: the low value is 21%, the high value is 33%, that is, hyperoxia-normoxia are alternated; the interval is 5 minutes, that is, 33% oxygen inhalation for 5 minutes and then 21% oxygen inhalation for 5 minutes is one cycle; the alternating frequency is 10 times, that is, 10 cycles; this 33%-21%, 5 minutes, 10 cycles mode is carried out continuously for 3 days, and the intermittent hyperoxia mode is as shown in the figure Figure 3 shown.

[0062] Continuous hyperoxia group: On the day after model preparation, as well as on the 2nd and 3rd days, the mice in the continuous hyperoxia group were placed in the hyperoxia chamber of the intermittent hyperoxia system described in Example 1 and given continuous hyperoxia (33% oxygen) intervention. The daily continuous hyperoxia time was the same as that of the intermittent hyperoxia group.

[0063] Model group: no further intervention was performed after the model was built.

[0064] Sham operation group: The left common carotid artery was not ligated, the distal branches of the middle cerebral artery were not cauterized, and no oxygen therapy intervention was performed during model construction.

[0065] 3. Neurological function assessment of mice

[0066] 3.1 Grid misstep test: The mice in the sham operation group, model group, continuous hyperoxia group, and intermittent hyperoxia group were placed on a grid (40 cm × 40 cm, small grid diameter: 2 cm × 2 cm, 50 cm above the ground). The mice were allowed to walk freely on the grid. When the right forelimbs missed a step, it was defined as an error. The error rate was measured by the percentage of the number of wrong steps of the right forelimb to the total number of steps of the right forelimb. The error rate results of the grid misstep experiment of mice in different groups are shown in Figure 2. Figure 4 As shown, n=5 for each group, *p<0.05, ****p<0.0001.

[0067] 3.2 Sticker Removal Experiment: This is a classic method for measuring sensorimotor deficits. The mice in the sham operation group, model group, continuous hyperoxia group, and intermittent hyperoxia group were placed in clean, transparent cages for 1 minute to adapt to the environment. Then, a sticky sticker (4mm×4mm) was attached to the palm side of the right front paw of the mouse with the same force. Afterwards, the mouse was gently placed back in the cage, and the time it took the mouse to touch and remove the sticker was recorded, with a maximum of 60 seconds. The results are as follows: Figure 5 and 6 As shown, Figure 5 The results of the touch time of the sticky paper removal experiment in different groups of mice, n = 10 per group, ****p < 0.0001; Figure 6 The results of the removal time of the sticker removal experiment in different groups of mice, n = 10 per group, ****p < 0.0001.

[0068] Depend on Figure 4-6 It can be found that compared with continuous hyperoxia, intermittent hyperoxia intervention on ischemic stroke mice using the intermittent hyperoxia system provided by the present invention can better shorten the time for sticker removal in ischemic stroke mice, reduce the grid misstep rate, and more effectively improve their motor sensory function deficits.

[0069] 4. Assessment of cerebral infarction volume

[0070] The cerebral infarction volume was evaluated on the 3rd day after the intervention of ischemic stroke model in mice in the sham operation group, model group, continuous hyperoxia group and intermittent hyperoxia group.

[0071] Among them, the MRI T2 evaluation results of cerebral infarction volume in different groups of mice are as follows: Figure 7 The quantitative calculation results of cerebral infarction volume of mice in different groups are shown in Figure 8 As shown, n=9 per group, ***p<0.001.

[0072] Depend on Figure 7-8 It can be found that intermittent hyperoxia treatment can significantly reduce the cerebral infarction volume of ischemic stroke mice, while continuous hyperoxia treatment failed to significantly reduce its infarction volume.

[0073] 5. Cerebral blood flow assessment

[0074] Laser speckle contrast imaging (LSCI) technology can non-invasively and with high resolution collect blood perfusion images of exposed tissues in real time, and monitor and record blood flow changes in real time.

[0075] First, the mice in the sham operation group, model group, continuous hyperoxia group, and intermittent hyperoxia group were completely anesthetized with inhaled anesthetic (isoflurane), and the mice were fixed in a prone position with a stereotaxic instrument. The skin on the top of the skull was disinfected and prepared, and a longitudinal skin incision was made to fully expose the skull. During the measurement, the mouse should be placed parallel to the laser speckle host. Turn on the laser speckle imaging system and turn on the "real-time imaging" function. Turn on the indicator light, adjust the position of the mouse, and illuminate the light source vertically in the middle of the exposed skull of the mouse. Magnify the image 2.4 times, and fill the field of view with cerebral blood flow images of different groups and different time points at the same position. Click autofocus, and turn off the indicator light after successful focus. Click "shoot" to capture the image. Export the image. After the measurement, suture the skin. During the measurement, pay attention to dripping physiological saline to keep the skull moist; pay attention to keep warm, and use a heating pad to maintain the body temperature at 37±0.5℃.

[0076] The test results are as follows Figure 9-10 As shown, Fig. 9 The cerebral blood flow diagram of mice in different groups. Fig.10 The quantitative results of cerebral blood flow in different groups of mice, n = 5 in each group. **p < 0.01, ****p < 0.0001, ### p<0.001.

[0077] Depend on Figure 9-10 It can be found that both intermittent hyperoxia and continuous hyperoxia treatment can increase the cerebral blood flow of ischemic stroke mice, but the degree of improvement of intermittent hyperoxia intervention using the intermittent hyperoxia system of the present invention is more obvious.

[0078] In summary, intermittent hyperoxia intervention on ischemic stroke mice using the intermittent hyperoxia system of the present invention can significantly improve the neurological function and cerebral infarction volume of the mice in the acute phase.

[0079] It should be noted that, in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0080] The above description is only a specific embodiment of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments described herein, but should conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An intermittent hyperoxia system, characterized in that: The intermittent hyperoxia system comprises a power supply module (1), a control module (2), a hyperoxia generating module (3) and a display module (4); The hyperoxia generating module (3) comprises an oxygen supply module (31), a nitrogen supply module (32), a carbon dioxide supply module (33), an air inlet (34), a valve control module (35), a gas flow control module (36), a gas mixing module (37), an air outlet (38) and a hyperoxia chamber (39); The oxygen supply module (31) is used to provide oxygen required by the hyperoxia chamber (39), the nitrogen supply module (32) is used to provide nitrogen required by the hyperoxia chamber (39), the carbon dioxide supply module (33) is used to provide carbon dioxide required by the hyperoxia chamber (39), the valve control module (35) is used to control the valve switches of the oxygen supply module (31), the nitrogen supply module (32) and the carbon dioxide supply module (33), the gas inlet (34) is used to allow the gas in the oxygen supply module (31), the nitrogen supply module (32) and the carbon dioxide supply module (33) to enter the gas mixing module (37), the gas flow control module (36) is used to control the flow of the gas, the gas mixing module (37) is used to mix the gas, and the gas outlet (38) is used to allow the mixed gas in the gas mixing module (37) to enter the hyperoxia chamber (39); The power module (1) is used to supply power to the intermittent hyperoxia system; The control module (2) is used to control the environmental parameters in the hyperoxia chamber (39); The display module (4) is used to display the environmental parameters in the hyperoxia chamber (39).

2. The intermittent hyperoxia system according to claim 1, characterized in that: The hyperoxia chamber (39) is provided with a brightness module (391), a detection module (392) and an observation module (393); The brightness module (391) is used to control the switch, light effect and light intensity of the light in the hyperoxia chamber (39); The detection module (392) is used to detect environmental parameters in the hyperoxia chamber (39) and transmit the data to the display module (4) for real-time display, and at the same time transmit the data to the control module (2) to determine whether the environment in the hyperoxia chamber (39) is normal; The observation module (393) is used to observe the state of the test subject in the hyperoxia chamber (39) in real time and transmit the data to the display module (4).

3. The intermittent hyperoxia system according to claim 2, characterized in that: The control module (2) comprises a setting module (21), an alarm module (22) and a correction module (23); The setting module (21) is used to set the environmental parameters in the hyperoxia chamber (39); The alarm module (22) is used to generate an alarm when the environmental parameter displayed by the display module (4) exceeds the environmental parameter range set by the setting module (21); The correction module (23) is used to perform correction when the environmental parameters displayed by the display module (4) deviate from the environmental parameters set by the setting module (21).

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