Weakly acidic shampoo for improving scalp environment and preparation method thereof

Abstract

The invention provides faintly acid shampoo for improving the scalp environment and a preparation method of the faintly acid shampoo, and belongs to the technical field of cosmetic washing and care. Comprising the following raw material components: 0.1-10% of a polygonum multiflorum extract, 0.1-10% of a rheum officinale extract, 0.1-10% of a cacumen biotae extract, 0.1-10% of a Chinese honey locust extract, 0.1-10% of an eclipta prostrata leaf extract, 0.1-10% of a glossy privet fruit extract, 0.1-10% of a ginger root extract and 0.1-10% of an almond extract. By researching and developing a preparation process technology for compounding a high-concentration Chinese herbal medicine dry powder aqueous solution and a special matrix, the problem that high-concentration shampoo is easy to layer and demulsify due to inconsistent ion activity or emulsification system is solved, and gain substitution of active components in the shampoo is realized through plant extracts; the scalp problems such as scalp folliculitis, scurf, tinea capitis and alopecia are effectively solved, the scalp environment is remarkably improved, and the effects of blacking and brightening hair, preventing alopecia and growing hair are achieved.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetic washing and care, and in particular to a weakly acidic shampoo for improving scalp environment and a preparation method thereof. Background Art

[0003] As people's living standards and health awareness improve, their expectations for toiletries have gone beyond the simple cleaning function, and they are pursuing safe, healthy and multifunctional products. Natural toiletries are very popular. Among them, shampoo products developed using traditional Chinese medicine resources are in urgent demand in the shampoo market segment because of their natural and mild characteristics and dual washing and conditioning effects.

[0004] As an important part of the skin microecology, the scalp microecology plays a key role in scalp health. The scalp barrier is composed of a sebum membrane composed of sebum, water and keratinocytes, and its microecology covers host cells, secretions, microorganisms and the microenvironment in which it is located. Scalp resident bacteria such as Propionibacterium, Staphylococcus, Malassezia, etc. can maintain the balance of the microecology under normal circumstances, but when the balance is broken, such as excessive reproduction of Malassezia to decompose lipids, sebum metabolism disorders, etc., it will cause diseases such as scalp inflammation, and cytokines in the scalp immune mechanism are also involved. Therefore, it is crucial to develop scalp care products that can maintain the balance of the scalp microecology.

[0005] At present, there are also some toiletries based on Chinese herbal extracts, such as Chinese herbal shampoo soaps or Chinese herbal shampoos. Among them, Chinese herbal shampoo soaps are mostly made of natural oils and have multiple functions such as anti-hair loss, degreasing, black hair, and anti-itching. They are also environmentally friendly and have little irritation to the scalp. They are loved by many consumers, but the hair is prone to dryness, astringency, and greasy after washing with shampoo soap, and the experience is not good. Traditional Chinese herbal shampoo is usually prepared using Chinese herbal extracts. After concentration, the concentration of Chinese herbal extracts is relatively high and the alcohol content is low. Although it has certain advantages, such as anti-hair loss, degreasing, black hair, and anti-itching functions, their efficacy is often relatively single, mainly targeting certain specific problems, and not repairing the scalp microecology as a whole. In addition, the amount of Chinese herbal extracts added in existing Chinese herbal shampoos is often small, resulting in a low content of active ingredients and a short residence time on the hair or scalp, which directly affects the actual use effect. If the proportion of Chinese herbal extracts in shampoo is directly increased, due to the strong ionic activity of Chinese herbal extracts, their content will increase and the drug concentration will become higher, making it difficult to compound into a stable shampoo product, causing stratification or collapse of the emulsification system. Summary of the invention

[0006] The object of the present invention is to provide a weakly acidic shampoo for improving the scalp environment and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A weakly acidic shampoo for improving scalp environment and a preparation method thereof, comprising the following raw material components, measured by mass percentage: 0.1-10% of Polygonum multiflorum extract, 0.1-10% of Rhubarb extract, 0.1-10% of Platycladus orientalis leaf extract, 0.1-10% of Gleditsia sinensis leaf extract, 0.1-10% of Channa ulmoides leaf extract, 0.1-10% of Ligustrum lucidum fruit extract, 0.1-10% of Ginger root extract and 0.1-10% of Apricot kernel extract.

[0009] Preferably, the raw materials further include, by mass percentage: 1-5% sublimed sulfur, 0.1-1% hydrolyzed wheat protein, 10-15% sodium laureth sulfate, 0.2-0.5% polyquaternium-10, 3-8% cocamidopropyl betaine, 0.1-0.5% citric acid, 0.05-0.2% disodium EDTA, 3-5% sodium lauroyl agar, 0.5-2% cocamide MEA, 0.5-1% guar hydroxypropyltrimethylammonium chloride and 0.01-0.08% methylisothiazolinone, and the balance is deionized water.

[0010] Preferably, the dry powder mixture of Polygonum multiflorum extract, Gleditsia sinensis extract, Rhubarb extract, Platycladus orientalis leaf extract, Channa chinensis leaf extract, Ligustrum lucidum fruit extract, ginger root extract and almond extract is added in an amount of not less than 5wt% of the total amount of raw materials.

[0011] The present invention also discloses a method for preparing a weakly acidic shampoo for improving the scalp environment, comprising the following steps:

[0012] S1, preparation of matrix compound liquid: deionized water, disodium EDTA, sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-10, guar hydroxypropyltrimonium chloride and cocamide MEA are placed in an emulsifying pot, heated to 82-85°C, stirred and dissolved, and finally a viscous transparent emulsion is formed; then the emulsion is cooled with cooling water at 21-25°C to 60°C, sodium lauroyl amino acid is added, stirred evenly, and cooled to 40°C;

[0013] S2, extract dissolution: add a dry powder mixture of Polygonum multiflorum extract, Rhubarb extract, Platycladus orientalis leaf extract, Gleditsia sinensis extract, Channa chus leaf extract, Ligustrum lucidum fruit extract, Ginger root extract and Apricot kernel extract into 80° C. deionized water at a concentration of 30-40%, stir to dissolve, place to cool to 40° C., and take the supernatant for later use;

[0014] S3, preparation of sulfur-water mixture: sublimated sulfur and deionized water were mixed in a weight ratio of 1:2.5-3.5, and then stirred at 2000 r / min for 30 min.

[0015] S4, compounding: adding the supernatant obtained in step S2 to the matrix compounding liquid, the compounding temperature is 40°C, mixing evenly, then adding the sulfur water mixture, citric acid, methylisothiazolinone, and hydrolyzed wheat protein prepared in step S3, stirring evenly, standing to defoam, and obtaining the weakly acidic shampoo for improving the scalp environment.

[0016] Preferably, in step S2, the method for preparing the dry powder mixture comprises the following steps:

[0017] (1) crushing the Polygonum multiflorum, adding it to boiling water and boiling it for 1-2 hours, cooling and filtering, then centrifuging the filtrate in a centrifuge, taking the upper layer liquid, and continuing to centrifuge the collected upper layer liquid until no precipitate is precipitated to obtain a clear liquid; then vacuum distilling and concentrating the obtained clear liquid, spray drying, crushing, and passing through a 100-mesh sieve to obtain a Polygonum multiflorum extract;

[0018] (2) preparing rhubarb, arborvitae leaf, sapodilla fruit, chrysanthemum leaf, glossy privet fruit, ginger root and almond respectively according to the preparation method of Polygonum multiflorum extract in step (1) above, to obtain rhubarb extract, arborvitae leaf extract, sapodilla fruit extract, chrysanthemum leaf extract, glossy privet fruit extract, ginger root extract and almond extract;

[0019] (3) Mixing the extract of Polygonum multiflorum, the extract of Rhubarb, the extract of Platycladus orientalis, the extract of Gleditsia sinensis, the extract of Channa chushen leaf, the extract of Ligustrum lucidum, the extract of ginger root and the extract of almond according to a certain proportion to obtain the dry powder mixture.

[0020] The beneficial effects of the above technical solution of the present invention are as follows:

[0021] 1. The present invention has developed a high-concentration Chinese herbal medicine dry powder aqueous solution and a special matrix compound preparation process technology, using hydrolyzed wheat protein, sodium lauryl polyol ether sulfate, cocamidopropyl betaine and the like as main raw ingredients, and through formula optimization, ensuring the emulsification effect of concentrated Chinese herbal medicine dry powder, especially sublimated sulfur, which is insoluble in water, has a large mass and is easy to precipitate. This solution prevents the sedimentation and stratification of sublimated sulfur, and achieves the stability of various physical and chemical indicators of the emulsified shampoo.

[0022] 2. This solution achieves the gain replacement of silicone softeners (such as polydimethylsiloxane), chemical anti-dandruff agents (such as piroctone olamine salt), hair growth agents (such as minoxidil), etc., and effectively solves scalp problems such as dry and yellow hair, scalp folliculitis, dandruff, tinea capitis, and hair loss. Long-term use can significantly improve the scalp environment and play a role in blackening hair, shining hair, preventing hair loss and promoting hair growth.

[0023] 3. This program is neither a simple addition of the effects of several ingredients nor a direct deduction of the effects of each Chinese medicine alone, but is obtained through the actual use of the users. The therapeutic effect is enhanced through synergy, making the interaction between drugs more harmonious and effective; through multi-target regulation, the human body functions are adjusted from multiple angles, which not only treats symptoms, but also improves the causes of the disease, achieving the purpose of treating both the symptoms and the root causes. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] By reading the following detailed description with reference to the accompanying drawings, the above and other objects, features and advantages of the exemplary embodiments of the present invention will become readily understood. In the accompanying drawings, several embodiments of the present invention are shown in an exemplary and non-limiting manner, and the same or corresponding reference numerals represent the same or corresponding parts, wherein:

[0025] Figure 1 Observation and follow-up efficacy chart provided for Application Example 2;

[0026] Figure 2 Observation and follow-up efficacy chart provided for Application Example 3;

[0027] Figure 3 Observation and follow-up efficacy diagram provided for Application Example 4;

[0028] Figure 4 Observation and follow-up efficacy diagram provided for Application Example 5;

[0029] Figure 5 Observation and follow-up efficacy diagram provided for Application Example 6;

[0030] Figure 6 This is the observation and follow-up efficacy chart provided for Application Example 7. DETAILED DESCRIPTION

[0031] In order to make the present application easier to understand, the present application will be further described in detail below in conjunction with embodiments. These embodiments are only for illustration and are not limited to the scope of application of the present application.

[0032] The invention discloses a weakly acidic shampoo for improving scalp environment. The shampoo comprises the following raw material components by mass percentage: 0.1-10% of polygonum multiflorum extract, 0.1-10% of rhubarb extract, 0.1-10% of orientalis leaf extract, 0.1-10% of sapodilla extract, 0.1-10% of chrysanthemum indica leaf extract, 0.1-10% of glossy privet fruit extract, 0.1-10% of ginger root extract and 0.1-10% of almond extract.

[0033] The above raw materials are disclosed as follows according to the TCM formula principle of "monarch, minister, assistant and messenger":

[0034] Platycladus orientalis leaves have the functions of clearing away heat and dampness, cooling blood and nourishing blood, and promoting hair growth and darkening hair. The flavonoids, tannins and volatile oils contained in Platycladus orientalis leaves can activate hair matrix cells, improve blood circulation of the scalp, revitalize hair follicles with declining hair growth ability, and promote healthy hair growth. By enhancing blood circulation, Platycladus orientalis leaves can also provide the scalp with necessary nutrients and play its role in nourishing and promoting hair growth. In addition, it can inhibit the rate of degeneration of hair epidermal cells, delay shedding, and help reduce the occurrence of seborrheic dermatosis.

[0035] The leaves of Channa intestine, Polygonum multiflorum, Gleditsia sinensis, and Rhubarb have the effects of hemostasis, cooling blood, astringency and antipruritic, tonifying liver and kidney, and promoting hair growth and blackening hair. They are all ministerial drugs. The leaves of Channa intestine contain flavonoid components such as quercetin, luteolin, apigenin, etc., as well as coumarin components, which have antibacterial effects on Staphylococcus aureus, Typhoid Bacillus, Shigella dysenteriae, and Pseudomonas aeruginosa. Polygonum multiflorum nourishes the liver and kidney, blackens hair, and is rich in anthraquinone compounds such as rhubarb, which has the effect of eliminating carbuncle and pus. Gleditsia sinensis is rich in various saponins, which can open the mind and eliminate phlegm, disperse nodules and reduce swelling, and has antibacterial and anti-inflammatory effects. At the same time, the soap base in the Gleditsia sinensis can well remove scalp oil. Rhubarb has the effects of purging heat and relieving constipation, cooling blood and detoxifying, removing blood stasis and dredge menstruation. It is rich in aloe-emodin, chrysophanol, physophanol methyl ether, etc., and has the effects of antibacterial, anti-inflammatory and hemostatic.

[0036] Ligustrum lucidum has the function of nourishing liver and kidney, improving eyesight and blackening hair. It is rich in various ingredients such as Ligustrum lucidum glycosides. Clinically, it is called Erzhi Pills together with Chanchangcao, becoming a pair of important medicines for nourishing liver and kidney and blackening hair. Ginger root has the function of warming yang and transforming water. Local application of the medicine can dilate scalp blood vessels and improve scalp microcirculation. Ligustrum lucidum and ginger root are adjuvants.

[0037] Almonds have the effect of resolving phlegm and removing phlegm and blood stasis, which can guide the medicine to the lung meridian. The lung governs the skin and hair.

[0038] For specific scalp problems, such as Malassezia overgrowth and sebum metabolism disorders, the various Chinese herbal ingredients in the formula show synergistic antibacterial and metabolic regulation capabilities. The antibacterial and anti-inflammatory effects of Platycladus orientalis, Gleditsia sinensis and Rhubarb can effectively inhibit the growth of harmful bacteria such as Malassezia and regulate the balance of scalp microbial flora; the nourishing effects of Polygonum multiflorum and Ligustrum lucidum on the liver and kidneys and the function of ginger root to improve microcirculation can help regulate scalp oil and nutrient metabolism, improve the scalp environment from the root, and solve scalp problems, which is more advantageous than single-function Chinese herbal formulas. In this formula, removing any Chinese herbal extract will cause a significant decrease in the body's immunity and tissue repair ability, reducing the repair ability of problematic skin.

[0039] The combination of various drugs regulates human functions from multiple targets. It is not a simple superposition of drug effects, but through the overall adjustment of the scalp microecological environment, improves the physiological state of the scalp, and plays the effects of clearing away heat and detoxification, reducing swelling and inflammation, cooling blood and activating blood circulation, removing dandruff and relieving itching, and blackening hair. This is the main drug mechanism of the present invention that can remove dandruff and treat folliculitis and tinea capitis.

[0040] The present invention also adds sublimated sulfur. Although sublimated sulfur is insoluble in water, it plays a very important role in the present formula. It has an inhibitory effect on common fungi and bacteria on the scalp, can enhance the antibacterial range of the shampoo, further improve the scalp microbial environment, and assist in solving problems such as scalp inflammation and tinea capitis. It works synergistically with the Chinese medicine extract and exerts a unique effect in maintaining the microecological balance of the scalp.

[0041] The raw materials, measured in percentage by mass, also include: 1-5% of sublimated sulfur, 0.1-1% of hydrolyzed wheat protein, 10-15% of sodium laureth sulfate, 0.2-0.5% of polyquaternium-10, 3-8% of cocamidopropyl betaine, 0.1-0.5% of citric acid, 0.05-0.2% of disodium EDTA, 3-5% of sodium lauroyl aminoacid, 0.5-2% of cocamide MEA, 0.5-1% of guar hydroxypropyltrimethylammonium chloride and 0.01-0.08% of methylisothiazolinone, and the balance is deionized water.

[0042] The present invention also discloses a method for preparing a weakly acidic shampoo for improving the scalp environment, which specifically comprises the following steps:

[0043] S1, preparation of matrix compound liquid: deionized water, disodium EDTA, sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-10, guar hydroxypropyltrimonium chloride and cocamide MEA are placed in an emulsifying pot, heated to 82-85°C, stirred and dissolved, and finally a viscous transparent emulsion is formed; then the emulsion is cooled with cooling water at 21-25°C to 60°C, sodium lauroyl amino acid is added, stirred evenly, and cooled to 40°C;

[0044] S2, extract dissolution: add a dry powder mixture of Polygonum multiflorum extract, Rhubarb extract, Platycladus orientalis leaf extract, Gleditsia sinensis extract, Channa chus leaf extract, Ligustrum lucidum fruit extract, Ginger root extract and Apricot kernel extract into 80° C. deionized water at a concentration of 30-40%, stir to dissolve, place to cool to 40° C., and take the supernatant for later use;

[0045] S3, preparation of sulfur-water mixture: sublimated sulfur and deionized water were mixed in a weight ratio of 1:2.5-3.5, and then stirred at 2000 r / min for 30 min.

[0046] S4, compounding: adding the supernatant obtained in step S2 to the matrix compounding liquid, the compounding temperature is 40°C, mixing evenly, then adding the sulfur water mixture prepared in step S3, and then adding citric acid, methylisothiazolinone and hydrolyzed wheat protein, stirring evenly, standing to defoam, and obtaining the weakly acidic shampoo for improving the scalp environment.

[0047] Wherein, the amount of dry powder mixture added in step S2 is not less than 5wt% of the total amount of raw materials. The preparation method of the dry powder mixture comprises: (1) crushing Polygonum multiflorum, adding it to boiling water and continuously boiling it for 1-2 hours, cooling and filtering, and then centrifuging the filtrate in a centrifuge at 2000r / min for 3 times, each time for 10 minutes, taking the upper layer of liquid, and continuing to centrifuge the collected upper layer of liquid until no precipitate is precipitated to obtain a clear liquid; then vacuum distilling and concentrating the obtained clear liquid, spray drying, crushing, and passing through a 100-mesh sieve to obtain Polygonum multiflorum extract; (2) preparing rhubarb, Platycladus orientalis leaf, Gleditsia sinensis leaf, Ligustrum lucidum fruit, ginger root and almond according to the preparation method of the Polygonum multiflorum extract, respectively, to obtain rhubarb extract, Platycladus orientalis leaf extract, Gleditsia sinensis leaf extract, Ligustrum lucidum fruit extract, ginger root extract and almond extract; (3) mixing Polygonum multiflorum extract, rhubarb extract, Platycladus orientalis leaf extract, Gleditsia sinensis leaf extract, Ligustrum lucidum fruit extract, ginger root extract and almond extract in proportion to obtain the dry powder mixture.

[0048] Compared with conventional processes, this method pays more attention to the compatibility of the matrix compound liquid with the high-concentration Chinese medicine extract. In step S1, during the preparation of the matrix compound liquid, specific raw materials such as polyquaternium-10, sodium laureth sulfate, cocamide MEA, etc. are selected, and the heating temperature of the emulsifying pot and the subsequent cooling and feeding process are strictly controlled to allow each component to fully dissolve and react to form a stable emulsion system. The composition and preparation conditions of this matrix lay the foundation for the subsequent addition of high-concentration Chinese medicine extracts, ensuring that the extracts can be evenly dispersed and stably present in the system, and the stability of the system is improved by finely controlling the raw materials and temperature.

[0049] In steps S2-S4, the dry powder mixture of the Chinese herbal extract is dissolved in deionized water at 80°C at a concentration of 30-40%, and the supernatant is taken and added to the matrix compounding liquid at 40°C for compounding, thereby ensuring the activity and stability of the components when mixed and effectively avoiding stratification or demulsification caused by temperature inappropriateness.

[0050] Sublimed sulfur is insoluble in water. During the preparation process, a specific sulfur-water mixture preparation step is used to make the sublimed sulfur form a relatively stable dispersed state of extremely fine particles in the system. Under the action of surfactants and stabilizers, the extremely fine particles can be evenly distributed in the shampoo, and will not cause product stratification due to their own sedimentation characteristics. Instead, it helps to increase the stability of the system. This is a unique application in high-concentration Chinese medicine shampoo systems.

[0051] Example 1

[0052] A weakly acidic shampoo for improving the scalp environment is prepared according to the above method. The weight of each raw material component is kg, and the total weight after proportioning is 100 kg, including: 3 kg of Polygonum multiflorum extract, 2 kg of Rhubarb extract, 4 kg of Platycladus orientalis leaf extract, 1.5 kg of Gleditsia sinensis extract, 2 kg of Channa chus leaf extract, 1 kg of Ligustrum lucidum extract, 1 kg of ginger root extract and 0.5 kg of almond extract, 3 kg of sublimated sulfur, 0.1 kg of hydrolyzed wheat protein, 15 kg of sodium laureth sulfate, 0.2 kg of polyquaternium-10, 8 kg of cocamidopropyl betaine, 0.1 kg of citric acid, 0.2 kg of disodium EDTA, 3 kg of sodium lauroyl amino acid, 0.5 kg of cocamide MEA, 0.5 kg of guar hydroxypropyltrimonium chloride, 0.08 kg of methylisothiazolinone, and the balance is deionized water.

[0053] The weakly acidic shampoo for improving the scalp environment is prepared by the above-mentioned preparation method: wherein the dry powder mixture is added to deionized water at a concentration of 35%; the sublimated sulfur and deionized water are mixed at a weight ratio of 1:2.5.

[0054] Example 2

[0055] A weakly acidic shampoo for improving the scalp environment is prepared according to the above method. The weight of each raw material component is kg, and the total weight after proportioning is 100 kg, including: 4 kg of Polygonum multiflorum extract, 3 kg of Rhubarb extract, 7 kg of Platycladus orientalis leaf extract, 2 kg of Gleditsia sinensis extract, 1 kg of Channa ulmoides leaf extract, 1.5 kg of Ligustrum lucidum extract, 0.4 kg of ginger root extract and 1.1 kg of almond extract, 2 kg of sublimated sulfur, 1 kg of hydrolyzed wheat protein, 10 kg of sodium laureth sulfate, 0.5 kg of polyquaternium-10, 3 kg of cocamidopropyl betaine, 0.5 kg of citric acid, 0.05 kg of disodium EDTA, 5 kg of sodium lauroyl amino acid, 2 kg of cocamide MEA, 1 kg of guar hydroxypropyltrimonium chloride, 0.01 kg of methylisothiazolinone, and the balance is deionized water.

[0056] The weakly acidic shampoo for improving the scalp environment is prepared by the above-mentioned preparation method: wherein the dry powder mixture is added to deionized water at a concentration of 30%; and the sublimated sulfur and deionized water are mixed at a weight ratio of 1:3.

[0057] Example 3

[0058] A weakly acidic shampoo for improving the scalp environment is prepared according to the above method. The weight of each raw material component is kg, and the total weight after proportioning is 100 kg, including: 1 kg of Polygonum multiflorum extract, 1 kg of Rhubarb extract, 3 kg of Platycladus orientalis leaf extract, 1 kg of Gleditsia sinensis extract, 3 kg of Channa chus leaf extract, 1.5 kg of Ligustrum lucidum extract, 0.8 kg of ginger root extract and 0.7 kg of almond extract, 1 kg of sublimated sulfur, 0.5 kg of hydrolyzed wheat protein, 13 kg of sodium laureth sulfate, 0.4 kg of polyquaternium-10, 6 kg of cocamidopropyl betaine, 0.3 kg of citric acid, 0.1 kg of disodium EDTA, 4 kg of sodium lauroyl amino acid, 1 kg of cocamide MEA, 0.8 kg of guar hydroxypropyltrimonium chloride, 0.05 kg of methylisothiazolinone, and the balance is deionized water.

[0059] The weakly acidic shampoo for improving the scalp environment is prepared by the above-mentioned preparation method: wherein the dry powder mixture is added to deionized water at a concentration of 30%; the sublimated sulfur and deionized water are mixed at a weight ratio of 1:3.5.

[0060] Example 4

[0061] A weakly acidic shampoo for improving the scalp environment is prepared according to the above method. The weight of each raw material component is kg, and the total weight after proportioning is 100 kg, including: 2 kg of Polygonum multiflorum extract, 2 kg of Rhubarb extract, 6 kg of Platycladus orientalis leaf extract, 3 kg of Gleditsia sinensis extract, 1.5 kg of Channa chus leaf extract, 2 kg of Ligustrum lucidum extract, 0.2 kg of ginger root extract and 0.3 kg of almond extract, 3 kg of sublimated sulfur, 0.5 kg of hydrolyzed wheat protein, 12 kg of sodium laureth sulfate, 0.3 kg of polyquaternium-10, 5 kg of cocamidopropyl betaine, 0.4 kg of citric acid, 0.09 kg of disodium EDTA, 4 kg of sodium lauroyl amino acid, 1.5 kg of cocamide MEA, 0.6 kg of guar hydroxypropyltrimonium chloride, 0.03 kg of methylisothiazolinone, and the balance is deionized water.

[0062] The weakly acidic shampoo for improving the scalp environment is prepared by the above-mentioned preparation method: wherein the dry powder mixture is added to deionized water at a concentration of 40%; and the sublimated sulfur and deionized water are mixed at a weight ratio of 1:3.

[0063] Comparative Example 1

[0064] The difference from Example 1 is that no sublimed sulfur is added.

[0065] Comparative Example 2

[0066] The difference between this embodiment and Example 1 is that no extract of Channa chuata leaves is added.

[0067] Comparative Example 3

[0068] The difference between this embodiment and Example 1 is that ginger root extract is not added.

[0069] Comparative Example 4

[0070] The difference between this embodiment and Example 1 is that no almond extract is added.

[0071] Comparative Example 5

[0072] The difference between this embodiment and Example 1 is that no rhubarb extract is added.

[0073] Comparative Example 6

[0074] The difference between the embodiment 1 and the embodiment 1 is that no cocamide MEA is added to the matrix compound liquid.

[0075] Comparative Example 7

[0076] The difference from Example 1 is that in the preparation of the matrix compound solution, the subsequent raw material components are directly added without cooling to 60° C.

[0077] Comparative Example 8

[0078] The difference from Example 1 is that in step S4, the compounding temperature is 50°C.

[0079] Comparative Example 9

[0080] The difference between this embodiment and Example 1 is that in step S4, the compounding temperature is 30°C.

[0081] The products of Examples 1-4 and Comparative Examples 1-9 were subjected to stability tests, wherein heat resistance and cold resistance were tested according to GB / T 29679-2013, and pH value was measured according to the dilution method in GB / T13531.1-2008. The test results are shown in Table 1:

[0082] Table 1

[0083]

[0084]

[0085] The products of Examples 1-4 and Comparative Examples 1-9 were tested for antibacterial ability against two common bacteria, Malassezia and Staphylococcus aureus, respectively, using the Oxford cup method. The experimental result judgment criteria are: the diameter of the antibacterial circle ≤ 10 mm indicates that the antibacterial effect is not obvious, the diameter of the antibacterial circle 10 mm-15 mm indicates moderate antibacterial effect, and the diameter of the antibacterial circle ≥ 15 mm indicates high antibacterial effect. The test results are shown in the following table:

[0086] Table 2

[0087]

[0088]

[0089] By comparison, it can be seen that this scheme can not only well retain the high concentration of active ingredients in these extracts, but also ensure that the Chinese medicine extracts can be evenly dispersed and remain stable in the system, so that the prepared shampoo can be stably stored without stratification, demulsification and thinning.

[0090] The antibacterial effect of the product of the present invention on Malassezia and Staphylococcus aureus showed a high antibacterial zone diameter of ≥18.3 mm, which shows that the shampoo prepared by this scheme has excellent antibacterial performance, among which the antibacterial property of comparative example 4 is also good, because the almond extract has a small effect on the overall antibacterial effect, and other ingredients compensate for this deficiency. Almond extract mainly plays a role in regulating the balance of scalp oil, preventing excessive oil accumulation from causing pore blockage and folliculitis, which is very important for maintaining a healthy scalp microenvironment.

[0091] Application Example 1

[0092] The product prepared in Example 1 was used for clinical testing, and 3,000 users with scalp or hair problems were collected and divided into five groups, as shown below:

[0093] Group A: 1000 patients with dandruff, including 580 males and 420 females, aged 12 to 73 years, with an average age of 40.3 years, and a disease course of 3 months to 8 years, with an average disease course of 3.1 years;

[0094] Group B: 800 patients with folliculitis, including 430 males and 370 females; aged 16-62 years, average age 39.0 years, disease course 1 month to 5 years, average disease course 1.2 years;

[0095] Group C: 500 patients with tinea capitis, including 230 males and 270 females, aged 6 to 76 years, with an average age of 41.0 years, and a disease course of 6 months to 12 years, with an average disease course of 3.6 years;

[0096] Group D: 500 patients with seborrheic alopecia, including 380 males and 120 females, aged 32 to 52 years old, with an average age of 41.0 years, and a disease course of 12 months to 10 years, with an average disease course of 5.1 years;

[0097] Group E: 200 patients with alopecia areata, including 80 males and 120 females, aged 8 months to 50 years, with an average age of 10.6 years, and a disease course of 1 month to 6 years, with an average disease course of 1.2 years;

[0098] Groups A, B, C, D and E all used the weakly acidic shampoo for improving the scalp environment provided by the present invention. The method of use was to wash the hair with the shampoo and gently massage for 5 minutes. Stay for 5 minutes, and the use time was 1 to 3 months. After 3 to 12 months of follow-up observation of all treatment groups, the changes in the main symptoms of dandruff, folliculitis, tinea capitis, etc. before and after treatment were observed, and the changes in the microecology of the scalp environment were observed with a scalp detector, and the clinical effectiveness was summarized.

[0099] The total effective rate is calculated according to the following formula:

[0100] Total effective rate = [(number of cured cases + number of improved cases) ÷ total number of cases] × 100%

[0101] Among them, Group A, cure criteria: complete disappearance of dandruff, disappearance of itching, normal results of scalp detector, and no recurrence after two weeks of observation; improvement criteria: significant reduction of dandruff, relief or disappearance of itching; ineffective criteria: no improvement of dandruff and itching.

[0102] Group B, cure criteria: complete disappearance of folliculitis, disappearance of local redness, swelling, itching and pain, and normal results of scalp detector; improvement criteria: reduction in the number of folliculitis, and significant relief of redness, swelling, itching and pain; ineffectiveness criteria: no reduction in the number of folliculitis, and no relief of redness, swelling, itching and pain.

[0103] Group C, cure criteria: tinea capitis scales and rashes disappear, itching disappears, and scalp detector tests are normal; improvement criteria: tinea capitis rashes disappear but there are still a few scales, itching disappears; ineffective criteria: tinea capitis remains the same as before.

[0104] Group D, cure criteria: hair loss is within the normal range, hair volume increases by more than double, and the hair is thick and strong; improvement criteria: hair loss is within the normal range, hair volume increases by less than double or the new hair is still fine and fluffy; ineffective criteria: no improvement in hair loss.

[0105] Group E, cure criteria: normal hair growth in alopecia areata; improvement criteria: sparse or fine hair growth in alopecia areata; ineffective criteria: no obvious changes in alopecia areata, no hair growth.

[0106] The test results are shown in Table 3:

[0107] Table 3

[0108] cure Improvement invalid Total Effectiveness Group A (Dandruff) 860(86.0％) 125(12.5％) 15(1.5％) 98.5％ Group B (folliculitis) 686(85.8％) 102(12.8％) 12(4.2％) 95.8％ Group C (tinea capitis) 386(77.2％) 94(18.8％) 20(4.0％) 96.0％ Group D (Seborrheic Alopecia) 136(27.2％) 332(66.4％) 32(6.4％) 93.6％ Group E (Alopecia Areata) 182(91.0％) 11(5.5％) 7(3.5％) 96.5％

[0109] Application Example 2

[0110] Hai, female, 19 years old, from Xinghualing District, Shanxi Province, was diagnosed with dandruff and folliculitis. From June 10, 2023 to September 1, 2023, she used the weakly acidic shampoo provided in Example 1 of the present invention to improve the scalp environment. After more than 2 months of use, the symptoms disappeared and there was no recurrence after 7 months of follow-up. The effects before and after use and the comparison of the scalp detector are shown in Figure 1: Before using the scalp detector, there was a lot of dandruff, the skin was flushed, and the vortex at the root of the hair follicle disappeared ( Figure 1 a) A lot of dandruff can be seen on the hair ( Figure 1 c) After using the scalp detector, the scalp turned bluish white, returning to normal, and the roots of the hair follicles were clearly visible ( Figure 1 b), dandruff completely disappeared ( Figure 1 d).

[0111] Application Example 3

[0112] Zhang, male, 26 years old, from Langfang City, Hebei Province, has alopecia all over his head and has suffered from alopecia symptoms for 3 years. He used the weakly acidic shampoo for improving the scalp environment provided by Example 1 of the present invention from September 29, 2022 to April 21, 2023, and there was no recurrence after 10 months of follow-up. The effects before and after using the shampoo of the present invention and the comparison of the scalp detector are shown in Figure 2 :Occlusion of hair follicle opening under scalp detector before use ( Figure 2 a), no hair growth visible to the naked eye ( Figure 2 c) After using the scalp detector, the scalp is bluish white and the growth of hair follicles is clearly visible ( Figure 2 b), good hair growth ( Figure 2 d).

[0113] Application Example 4

[0114] Zhang, male, 78 years old, from Shanghai, was diagnosed with white ringworm; from August 8, 2023 to November 26, 2023, he used the weakly acidic shampoo provided in Example 2 of the present invention to improve the scalp environment, and there was no recurrence after 3 months of follow-up. The effects before and after using the shampoo of the present invention and the scalp detector are compared. Figure 3 : Before using the scalp detector, the scalp was flushed and a lot of scales accumulated on the surface ( Figure 3 a), scalp white ringworm can be seen with naked eyes ( Figure 3 c) After using the scalp detector, the scalp is bluish white and the scales disappear ( Figure 3 b), scalp returns to normal ( Figure 3 d).

[0115] Application Example 5

[0116] Liu, male, 43 years old, from Zhenjiang, Jiangsu Province, was diagnosed with tinea capitis, scalp flushing, and white scaly spots. From December 29, 2023 to February 10, 2024, he used the weakly acidic shampoo provided in Example 2 of the present invention to improve the scalp environment, and there was no recurrence after one month of follow-up. The effects before and after using the shampoo of the present invention and the scalp detector are compared. Figure 4 : Before using the scalp detector, the scalp was flushed and a lot of scales accumulated on the surface ( Figure 4 a), tinea capitis can be seen with naked eyes ( Figure 4 c) After using the scalp detector, the scalp is bluish white and the scales disappear ( Figure 4 b), scalp returns to normal ( Figure 4 d).

[0117] Application Example 6

[0118] Zhang, male, 43 years old, from Yanshan County, Cangzhou City, Hebei Province, was diagnosed with seborrheic alopecia; from August 25, 2023 to December 28, 2023, he used the weakly acidic shampoo provided in Example 3 of the present invention to improve the scalp environment, and there was no recurrence after 3 months of follow-up. The effects before and after using the shampoo of the present invention and the scalp detector are compared. Figure 5 : Before using the scalp detector, the hair under the scalp detector is fine and soft, and the exit of the hair follicle is mostly single hair ( Figure 5 a), sparse hair is visible to the naked eye ( Figure 5 c) After using the scalp detector, the hair is thick and double hair can be seen at the exit of the hair follicle ( Figure 5 b), the brightness increased significantly ( Figure 5 d).

[0119] Application Example 7

[0120] Gong, male, 19 years old, from Heshan District, Yiyang City, Hunan Province, was diagnosed with folliculitis. From July 12, 2023 to August 4, 2023, he used the weakly acidic shampoo for improving the scalp environment provided by Example 4 of the present invention. There was no recurrence during the 9-month follow-up. The effects before and after using the shampoo of the present invention and the scalp detector were compared. Figure 6 : Before using the scalp detector, the scalp was flushed and a lot of scales accumulated on the surface ( Figure 6 a), folliculitis can be seen all over the head with naked eyes ( Figure 6 c) After using the scalp detector, the scalp is bluish white, the hair roots are clearly visible, and the scales disappear ( Figure 6 b), scalp returns to normal ( Figure 6 d).

[0121] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in the field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A weakly acidic shampoo for improving scalp environment, characterized in that: Calculated by mass percentage, the raw material components include: 0.1-10% of Polygonum multiflorum extract, 0.1-10% of Rhubarb extract, 0.1-10% of Platycladus orientalis leaf extract, 0.1-10% of Gleditsia sinensis leaf extract, 0.1-10% of Channa ulmoides leaf extract, 0.1-10% of Ligustrum lucidum fruit extract, 0.1-10% of Ginger root extract and 0.1-10% of Apricot kernel extract.

2. The weakly acidic shampoo for improving scalp environment according to claim 1, characterized in that: Calculated by mass percentage, the raw materials also include: 1-5% sublimated sulfur, 0.1-1% hydrolyzed wheat protein, 10-15% sodium laureth sulfate, 0.2-0.5% polyquaternium-10, 3-8% cocamidopropyl betaine, 0.1-0.5% citric acid, 0.05-0.2% disodium EDTA, 3-5% sodium lauroyl acid, 0.5-2% cocamide MEA, 0.5-1% guar hydroxypropyltrimethylammonium chloride and 0.01-0.08% methylisothiazolinone, and the balance is deionized water.

3. The weakly acidic shampoo for improving scalp environment according to claim 1, characterized in that: The dry powder mixture of the extract of Polygonum multiflorum, the extract of Gleditsia sinensis, the extract of Rhubarb, the extract of Platycladus orientalis, the extract of Channa chinensis, the extract of Ligustrum lucidum, the extract of ginger root and the extract of Apricot kernel is added in an amount not less than 5wt% of the total amount of the raw materials.

4. A method for preparing a weakly acidic shampoo for improving scalp environment according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1, preparation of matrix compound liquid: deionized water, disodium EDTA, sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-10, guar hydroxypropyltrimonium chloride and cocamide MEA are placed in an emulsifying pot, heated to 82-85°C, stirred and dissolved, and finally a viscous transparent emulsion is formed; then the emulsion is cooled with cooling water at 21-25°C to 60°C, sodium lauroyl amino acid is added, stirred evenly, and cooled to 40°C; S2, extract dissolution: add a dry powder mixture of Polygonum multiflorum extract, Rhubarb extract, Platycladus orientalis leaf extract, Gleditsia sinensis extract, Channa chus leaf extract, Ligustrum lucidum fruit extract, Ginger root extract and Apricot kernel extract into 80° C. deionized water at a concentration of 30-40%, stir to dissolve, place to cool to 40° C., and take the supernatant for later use; S3, preparation of sulfur-water mixture: sublimated sulfur and deionized water were mixed in a weight ratio of 1:2.5-3.5, and then stirred at 2000 r / min for 30 min. S4, compounding: adding the supernatant obtained in step S2 to the matrix compounding liquid, the compounding temperature is 40°C, mixing evenly, then adding the sulfur water mixture prepared in step S3, adding citric acid, methylisothiazolinone and hydrolyzed wheat protein, stirring evenly, standing to defoam, and obtaining the weakly acidic shampoo for improving the scalp environment.

5. The method for preparing the weakly acidic shampoo for improving the scalp environment according to claim 4, characterized in that: In step S2, the method for preparing the dry powder mixture comprises the following steps: (1) crushing the Polygonum multiflorum, adding it to boiling water and boiling it for 1-2 hours, cooling and filtering, then centrifuging the filtrate in a centrifuge, taking the upper layer liquid, and continuing to centrifuge the collected upper layer liquid until no precipitate is precipitated to obtain a clear liquid; then vacuum distilling and concentrating the obtained clear liquid, spray drying, crushing, and passing through a 100-mesh sieve to obtain a Polygonum multiflorum extract; (2) preparing rhubarb, arborvitae leaf, sapodilla fruit, chrysanthemum leaf, glossy privet fruit, ginger root and almond respectively according to the preparation method of Polygonum multiflorum extract in step (1) above, to obtain rhubarb extract, arborvitae leaf extract, sapodilla fruit extract, chrysanthemum leaf extract, glossy privet fruit extract, ginger root extract and almond extract; (3) Mixing the extract of Polygonum multiflorum, the extract of Rhubarb, the extract of Platycladus orientalis, the extract of Gleditsia sinensis, the extract of Channa chushen leaf, the extract of Ligustrum lucidum, the extract of ginger root and the extract of almond according to a certain proportion to obtain the dry powder mixture.

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