Skin disease traditional Chinese medicine composition for dermatitis and preparation method of skin disease traditional Chinese medicine composition
By preparing a dermatitis Chinese medicine composition for dermatitis, combined with an oral Chinese medicine preparation and external honeysuckle, the problem of long treatment cycle in the prior art is solved, and faster and more effective dermatitis treatment effect is achieved.
Patent Information
- Application Number
- CN202510254365.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-05
- Publication Date
- 2025-05-13
AI Technical Summary
The prior art cannot be taken orally and externally at the same time, resulting in a long treatment cycle of dermatitis, unable to fully alleviate the pain of patients, and increases medical costs and the harm of drugs to the body.
A Chinese medicine composition for dermatitis for dermatitis, including monarch, minister, adjuvant and medicine, is used to prepare Chinese medicine preparations and honeysuckle dew through decoction or extraction, and combine with external application of specific medicines to achieve simultaneous treatment inside and outside.
It shortens the treatment cycle of dermatitis, significantly reduces the pain of patients, reduces medical costs and the harm of drugs to the body, and improves the treatment effect.
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Figure CN119970887A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of dermatitis treatment, and in particular to a skin disease Chinese medicine composition for dermatitis and a preparation method thereof. Background Art
[0002] As the part of the human body with the largest contact area with the outside world, the skin is easily affected by the internal and external conditions and environment, and is prone to various skin symptoms. Eczema and dermatitis are common and frequent skin diseases in clinical practice, accounting for about 15% to 30% of the outpatient visits to dermatology departments. Acute eczema and dermatitis are particularly common. Because they often have strong itching, a lot of exudate, and are prone to recurrence, especially long-term recurrence and widespread skin lesions, they are more painful. They are one of the key topics in clinical and basic research on skin diseases at home and abroad. Modern medicine has proved that the pathological changes of eczema are intercellular edema (sponge formation) and intracellular edema in the epidermis, and there are capillary dilation, edema and mononuclear cell infiltration in the superficial dermis. From a clinical point of view, it is often difficult to find a clear cause for eczema.
[0003] After searching, Chinese patent number CN106728166B discloses a Chinese medicine composition for treating eczema dermatitis. Although the Chinese medicine composition has simple ingredients, clear efficacy, does not contain toxic ingredients, has a special fragrance, no odor, is easy to apply externally, has a significant therapeutic effect on eczema dermatitis, is not prone to recurrence, and can achieve the effect of treating both the symptoms and the root cause, it cannot be taken orally and applied externally at the same time, which makes the patient's treatment cycle longer and cannot fully alleviate the patient's pain, which not only increases the patient's medical costs, but also increases the harm of the drug to the body. Summary of the invention
[0004] The purpose of the present invention is to solve the defects in the prior art and to propose a Chinese medicine composition for treating dermatitis and a preparation method thereof.
[0005] In order to achieve the above object, the present invention adopts the following technical solutions:
[0006] A Chinese medicine composition for skin diseases of dermatitis, the Chinese medicine composition is composed of the following Chinese medicines in parts by weight:
[0007] The main drug is selected from one or more of the following drugs: 10 parts of Gentiana scabra, 10 parts of Saposhnikovia divaricata and 30 parts of Sophora flavescens;
[0008] The ministerial drug is selected from one or more of the following drugs: 10 parts of Scutellaria baicalensis, 10 parts of Gardenia jasminoides, 10 parts of Alisma orientalis, 6 parts of Akebia, 10 parts of Plantago, 10 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 10 parts of Astragalus membranaceus and 20 parts of Phellodendron chinense;
[0009] The adjuvant is selected from one or more of the following drugs: 6 parts of Gardenia, 6 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 10 parts of Ephedra, 10 parts of Nepeta spicate, 10 parts of Mentha, 10 parts of Rhubarb, 10 parts of Sodium Sulfate, 60 parts of Talcum, 10 parts of Angelica sinensis, 15 parts of Rehmannia glutinosa, 6 parts of Bupleurum, 10 parts of White Peony Root, 10-30 parts of Salvia miltiorrhiza, 10-30 parts of Red Peony Root, 10-30 parts of Lithospermum officinale, 15 parts of Dictamni Cortex, 15 parts of Kochia scoparia, 15 parts of Cnidium monnieri, 20 parts of Honeysuckle and 20 parts of Forsythia suspensa;
[0010] The adjuvant drug is selected from one or more of the following drugs: 6 parts of raw (roasted) licorice;
[0011] In addition, honeysuckle dew and specific medicine can be used for external application.
[0012] Furthermore, the Chinese medicine composition is prepared as a Chinese medicine preparation, which is a paste prescription, pill, pill, decoction, granule, capsule, powder or tablet; the specific medicine is prepared from 30 parts of Xanthium sibiricum, 15 parts of Cnidium monnieri and 15 parts of Dictamni cortex.
[0013] Furthermore, the dermatitis includes one or more of eczema, dermatitis, atopic dermatitis, allergic dermatitis, urticaria, and psoriasis, and the atopic dermatitis includes simple atopic dermatitis and mixed atopic dermatitis.
[0014] A method for preparing a Chinese medicine composition for treating dermatitis, wherein the specific steps of the method for preparing the Chinese medicine composition for treating dermatitis are as follows:
[0015] S1. Pretreatment: Select the required medicinal materials according to the Chinese medicine prescription, ensure the quality and source of the medicinal materials, and then accurately weigh each medicinal material according to the weight specified in the prescription;
[0016] S2. Pretreatment of medicinal materials: Clean the medicinal materials as necessary to remove impurities and dirt on the surface, and then slice or crush the medicinal materials as needed to facilitate decoction or extraction;
[0017] S3, decoction or extraction: put the pretreated medicinal materials into a decoction pot, add an appropriate amount of water, and then decoct with a slow fire for 10 to 30 minutes to fully dissolve the effective ingredients in the medicinal materials in the water to obtain a decoction liquid. During the decoction process, the heat and time can be adjusted as needed to ensure the extraction effect. At the same time, the crushed honeysuckle is dynamically extracted with petroleum ether, and the extract is filtered to recover the petroleum ether to form a honeysuckle extract;
[0018] S4, filtering and concentrating: after the decoction is completed, the decoction liquid is cooled to 40 degrees Celsius, the liquid is filtered to remove the residue, and the filtered liquid is concentrated to reduce the volume and increase the concentration to form a concentrated liquid, and the honeysuckle extract is concentrated to obtain a honeysuckle fragrant extract;
[0019] S5. Formulation: The concentrated liquid medicine is made into different dosage forms, such as decoction, pills, powder or paste, as needed. During the formulation forming process, the stability and effectiveness of the dosage form need to be ensured;
[0020] S6. Preparation of honeysuckle dew: subjecting the honeysuckle extracted with petroleum ether in step S3 to reflux extraction with ethyl acetate, filtering the extract to recover ethyl acetate, and concentrating the extract to obtain total honeysuckle flavonoids, and then mixing the obtained honeysuckle extract with total honeysuckle flavonoids and performing steam distillation to obtain honeysuckle dew.
[0021] Furthermore, the decoction pot in step S3 should be made of a ceramic pot, a casserole or a stainless steel vessel, and avoid using corrosive vessels such as iron and aluminum to prevent chemical reactions with the medicinal materials that affect the efficacy.
[0022] Furthermore, the medicinal materials used for decoction in step S3 need to be soaked for a period of time before decoction so that the active ingredients in the medicinal materials can be better dissolved in water. When decocting, they should be boiled over high heat first, and then simmered over low heat to ensure that the medicinal liquid is fully decocted.
[0023] Furthermore, during the preparation molding process in step S5, if it is necessary to add glue or auxiliary materials, it should be ensured that they are compatible with the drug solution and avoid affecting the efficacy of the drug.
[0024] Compared with the prior art, the present invention has the following beneficial effects:
[0025] The Chinese medicine composition prepared by the invention has a short treatment cycle for dermatitis and a better effect. The Chinese medicine preparation can be taken orally, and honeysuckle dew and specific medicine liquid can be applied externally. The two can be carried out simultaneously to shorten the treatment cycle of the patient, fully alleviate the pain of the patient, not only reduce the medical cost of the patient, but also reduce the harm of the medicine to the patient's body. At the same time, the scutellaria baicalensis, phellodendron chinense and sophora flavescens in the Chinese medicine composition assist the main medicine to strengthen the effect of clearing heat and drying dampness, the sophora flavescens can also dispel wind and relieve itching, the kochia scoparia can dispel wind and relieve itching, and the poria can strengthen the spleen and eliminate dampness for the skin itching caused by damp heat, and prevent the bitter and cold medicines from damaging the spleen and stomach, all of which can improve the treatment effect of the Chinese medicine composition on dermatitis. BRIEF DESCRIPTION OF THE DRAWINGS
[0026] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention.
[0027] Figure 1 The present invention provides a process flow chart of a method for preparing a Chinese medicine composition for treating dermatitis. DETAILED DESCRIPTION
[0028] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.
[0029] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.
[0030] Embodiment 1:
[0031] See also Figure 1 The present invention provides a technical solution: a method for preparing a Chinese medicine composition for treating dermatitis. The specific operation steps of the method for preparing a Chinese medicine composition for treating dermatitis are as follows:
[0032] S1. Pretreatment: According to the Chinese medicine prescription, the required medicinal materials are selected, and the Chinese medicine composition is composed of the following Chinese medicines in parts by weight: the main medicine is selected from one or more of the following medicines: 10 parts of Gentiana scabra, 10 parts of Saposhnikovia divaricata and 30 parts of Sophora flavescens; the auxiliary medicine is selected from one or more of the following medicines: 10 parts of Scutellaria baicalensis, 10 parts of Gardenia jasminoides, 10 parts of Alisma orientalis, 6 parts of Akebia tonga, 10 parts of Plantago asiatica, 10 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 10 parts of Astragalus membranaceus and 20 parts of Phellodendron chinense; the adjuvant is selected from one or more of the following medicines: 6 parts of Gardenia jasminoides, 6 parts of Poria cocos, 20 parts of Atractylodes macrocephala 10 parts, ephedra 10 parts, schizonepeta spicate 10 parts, mint 10 parts, rhubarb 10 parts, sodium sulfate 10 parts, talc 60 parts, angelica 10 parts, raw rehmannia 15 parts, bupleurum 6 parts, white peony 10 parts, salvia miltiorrhiza 30 parts, red peony root 30 parts, lithospermum officinale 30 parts, Dictamni 15 parts, Kochia scoparia 15 parts, Cnidium monnieri 15 parts, honeysuckle 20 parts and forsythia suspensa 20 parts; the medicine is selected from one or more of the following medicines: 6 parts of raw (roasted) licorice, and the quality and source of the medicinal materials are ensured to be reliable, and then each medicinal material is accurately weighed according to the weight portion specified in the prescription;
[0033] S2. Pretreatment of medicinal materials: Clean the medicinal materials as necessary to remove impurities and dirt on the surface, and then slice or crush the medicinal materials as needed to facilitate decoction or extraction;
[0034] S3, decoction or extraction: put the pretreated medicinal materials into a decoction pot, add an appropriate amount of water, and then decoct for 30 minutes with a slow fire to fully dissolve the effective ingredients in the medicinal materials in the water to obtain a decoction. During the decoction process, the heat and time can be adjusted as needed to ensure the extraction effect. At the same time, the crushed honeysuckle is dynamically extracted with petroleum ether, and the extract is filtered to recover the petroleum ether to form a honeysuckle extract;
[0035] S4, filtering and concentrating: after the decoction is completed, the decoction liquid is cooled to 40 degrees Celsius, the liquid is filtered to remove the residue, and the filtered liquid is concentrated to reduce the volume and increase the concentration to form a concentrated liquid, and the honeysuckle extract is concentrated to obtain a honeysuckle fragrant extract;
[0036] S5. Formulation: The concentrated liquid medicine is made into different dosage forms, such as decoction, pills, powder or paste, as needed. During the formulation forming process, the stability and effectiveness of the dosage form need to be ensured;
[0037] S6. Preparation of honeysuckle dew: subjecting the honeysuckle extracted with petroleum ether in step S3 to reflux extraction with ethyl acetate, filtering the extract to recover ethyl acetate, and concentrating the extract to obtain total honeysuckle flavonoids, and then mixing the obtained honeysuckle extract with total honeysuckle flavonoids and performing steam distillation to obtain honeysuckle dew.
[0038] Embodiment 2:
[0039] See also Figure 1 The present invention provides a technical solution: a method for preparing a Chinese medicine composition for treating dermatitis. The specific operation steps of the method for preparing a Chinese medicine composition for treating dermatitis are as follows:
[0040] S1. Pretreatment: According to the Chinese medicine prescription, the required medicinal materials are selected, and the Chinese medicine composition is composed of the following Chinese medicines in parts by weight: the main medicine is selected from one or more of the following medicines: 10 parts of Gentiana scabra, 10 parts of Saposhnikovia divaricata and 30 parts of Sophora flavescens; the auxiliary medicine is selected from one or more of the following medicines: 10 parts of Scutellaria baicalensis, 10 parts of Gardenia jasminoides, 10 parts of Alisma orientalis, 6 parts of Akebia tonga, 10 parts of Plantago asiatica, 10 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 10 parts of Astragalus membranaceus and 20 parts of Phellodendron chinense; the adjuvant is selected from one or more of the following medicines: 6 parts of Gardenia jasminoides, 6 parts of Poria cocos, 20 parts of Atractylodes macrocephala 10 parts, ephedra 10 parts, schizonepeta spicate 10 parts, mint 10 parts, rhubarb 10 parts, sodium sulfate 10 parts, talc 60 parts, angelica 10 parts, raw rehmannia glutinosa 15 parts, bupleurum 6 parts, white peony root 10 parts, salvia miltiorrhiza 10 parts, red peony root 10 parts, lithospermum officinale 10 parts, Dictamni 15 parts, Kochia scoparia 15 parts, Cnidium monnieri 15 parts, honeysuckle 20 parts and forsythia suspensa 20 parts; the medicine is selected from one or more of the following medicines: 6 parts of raw (roasted) licorice, and the quality and source of the medicinal materials are ensured to be reliable, and then each medicinal material is accurately weighed according to the weight portion specified in the prescription;
[0041] S2. Pretreatment of medicinal materials: Clean the medicinal materials as necessary to remove impurities and dirt on the surface, and then slice or crush the medicinal materials as needed to facilitate decoction or extraction;
[0042] S3, decoction or extraction: put the pretreated medicinal materials into a decoction pot, add an appropriate amount of water, and then decoct for 10 minutes with a slow fire to fully dissolve the effective ingredients in the medicinal materials in the water to obtain a decoction. During the decoction process, the heat and time can be adjusted as needed to ensure the extraction effect. At the same time, the crushed honeysuckle is dynamically extracted with petroleum ether, and the extract is filtered to recover the petroleum ether to form a honeysuckle extract;
[0043] S4, filtering and concentrating: after the decoction is completed, the decoction liquid is cooled to 40 degrees Celsius, the liquid is filtered to remove the residue, and the filtered liquid is concentrated to reduce the volume and increase the concentration to form a concentrated liquid, and the honeysuckle extract is concentrated to obtain a honeysuckle fragrant extract;
[0044] S5. Formulation: The concentrated liquid medicine is made into different dosage forms, such as decoction, pills, powder or paste, as needed. During the formulation forming process, the stability and effectiveness of the dosage form need to be ensured;
[0045] S6. Preparation of honeysuckle dew: subjecting the honeysuckle extracted with petroleum ether in step S3 to reflux extraction with ethyl acetate, filtering the extract to recover ethyl acetate, and concentrating the extract to obtain total honeysuckle flavonoids, and then mixing the obtained honeysuckle extract with total honeysuckle flavonoids and performing steam distillation to obtain honeysuckle dew.
[0046] Embodiment 3:
[0047] See also Figure 1 The present invention provides a technical solution: a method for preparing a Chinese medicine composition for treating dermatitis. The specific operation steps of the method for preparing a Chinese medicine composition for treating dermatitis are as follows:
[0048] S1. Pretreatment: According to the Chinese medicine prescription, the required medicinal materials are selected, and the Chinese medicine composition is composed of the following Chinese medicines in parts by weight: the main medicine is selected from one or more of the following medicines: 10 parts of Gentiana scabra, 10 parts of Saposhnikovia divaricata and 30 parts of Sophora flavescens; the auxiliary medicine is selected from one or more of the following medicines: 10 parts of Scutellaria baicalensis, 10 parts of Gardenia jasminoides, 10 parts of Alisma orientalis, 6 parts of Akebia tonga, 10 parts of Plantago asiatica, 10 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 10 parts of Astragalus membranaceus and 20 parts of Phellodendron chinense; the adjuvant is selected from one or more of the following medicines: 6 parts of Gardenia jasminoides, 6 parts of Poria cocos, 20 parts of Atractylodes macrocephala 10 parts, ephedra 10 parts, schizonepeta spicate 10 parts, mint 10 parts, rhubarb 10 parts, sodium sulfate 10 parts, talc 60 parts, angelica 10 parts, raw rehmannia glutinosa 15 parts, bupleurum 6 parts, white peony root 10 parts, salvia miltiorrhiza 20 parts, red peony root 20 parts, lithospermum officinale 20 parts, Dictamni 15 parts, Kochia scoparia 15 parts, Cnidium monnieri 15 parts, honeysuckle 20 parts and forsythia suspensa 20 parts; the medicine is selected from one or more of the following medicines: 6 parts of raw (roasted) licorice, and the quality and source of the medicinal materials are ensured to be reliable, and then each medicinal material is accurately weighed according to the weight portion specified in the prescription;
[0049] S2. Pretreatment of medicinal materials: Clean the medicinal materials as necessary to remove impurities and dirt on the surface, and then slice or crush the medicinal materials as needed to facilitate decoction or extraction;
[0050] S3, decoction or extraction: put the pretreated medicinal materials into a decoction pot, add an appropriate amount of water, and then decoct for 20 minutes with a slow fire to fully dissolve the effective ingredients in the medicinal materials in the water to obtain a decoction. During the decoction process, the heat and time can be adjusted as needed to ensure the extraction effect. At the same time, the crushed honeysuckle is dynamically extracted with petroleum ether, and the extract is filtered to recover the petroleum ether to form a honeysuckle extract;
[0051] S4, filtering and concentrating: after the decoction is completed, the decoction liquid is cooled to 40 degrees Celsius, the liquid is filtered to remove the residue, and the filtered liquid is concentrated to reduce the volume and increase the concentration to form a concentrated liquid, and the honeysuckle extract is concentrated to obtain a honeysuckle fragrant extract;
[0052] S5. Formulation: The concentrated liquid medicine is made into different dosage forms, such as decoction, pills, powder or paste, as needed. During the formulation forming process, the stability and effectiveness of the dosage form need to be ensured;
[0053] S6. Preparation of honeysuckle dew: subjecting the honeysuckle extracted with petroleum ether in step S3 to reflux extraction with ethyl acetate, filtering the extract to recover ethyl acetate, and concentrating the extract to obtain total honeysuckle flavonoids, and then mixing the obtained honeysuckle extract with total honeysuckle flavonoids and performing steam distillation to obtain honeysuckle dew.
[0054] Comparative Example 1:
[0055] This comparative example is a Chinese medicine composition prepared from the Chinese medicine composition for treating eczema dermatitis disclosed in Chinese patent number CN106728166B.
[0056] Two portions of the Chinese medicine compositions prepared in Examples 1-3 were respectively extracted, recorded as A1, A2, B1, B2, C1 and C2, and then compared with two portions of the Chinese medicine compositions of Comparative Example 1, recorded as E1 and E2, and dermatitis medical experiments were carried out at room temperature, and the following data were measured:
[0057]
[0058] By comparison, it can be seen that the Chinese medicine composition prepared in Examples 1, 2 and 3 has a short treatment cycle for dermatitis and a better effect. At the same time, the Chinese medicine preparation can be taken orally, and the honeysuckle dew and specific medicine can be applied externally. The two are carried out simultaneously to shorten the patient's treatment cycle, which can fully alleviate the patient's pain, not only reducing the patient's medical costs, but also reducing the harm of the drug to the patient's body. At the same time, the scutellaria baicalensis, phellodendron chinense and sophora flavescens in the Chinese medicine composition assist the main medicine in strengthening the effect of clearing heat and drying dampness, sophora flavescens can also dispel wind and relieve itching, and the fructus kochiae dispels wind and relieves itching. For skin itching caused by damp heat, Poria invigorates the spleen and eliminates dampness, and prevents bitter and cold drugs from damaging the spleen and stomach, which can improve the therapeutic effect of the Chinese medicine composition on dermatitis.
[0059] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.
Claims
1. A Chinese medicine composition for treating dermatitis, characterized in that: The Chinese medicine composition is composed of the following Chinese medicines in parts by weight: The main drug is selected from one or more of the following drugs: 10 parts of Gentiana scabra, 10 parts of Saposhnikovia divaricata and 30 parts of Sophora flavescens; The ministerial drug is selected from one or more of the following drugs: 10 parts of Scutellaria baicalensis, 10 parts of Gardenia jasminoides, 10 parts of Alisma orientalis, 6 parts of Akebia, 10 parts of Plantago, 10 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 10 parts of Astragalus membranaceus and 20 parts of Phellodendron chinense; The adjuvant is selected from one or more of the following drugs: 6 parts of Gardenia, 6 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 10 parts of Ephedra, 10 parts of Nepeta spicate, 10 parts of Mentha, 10 parts of Rhubarb, 10 parts of Sodium Sulfate, 60 parts of Talcum, 10 parts of Angelica sinensis, 15 parts of Rehmannia glutinosa, 6 parts of Bupleurum, 10 parts of White Peony Root, 10-30 parts of Salvia miltiorrhiza, 10-30 parts of Red Peony Root, 10-30 parts of Lithospermum officinale, 15 parts of Dictamni Cortex, 15 parts of Kochia scoparia, 15 parts of Cnidium monnieri, 20 parts of Honeysuckle and 20 parts of Forsythia suspensa; The adjuvant drug is selected from one or more of the following drugs: 6 parts of raw (roasted) licorice; In addition, honeysuckle dew and specific medicine can be used for external application.
2. A Chinese medicine composition for treating dermatitis according to claim 1, characterized in that: The Chinese medicine composition is prepared as a Chinese medicine preparation, which is a paste prescription, a pill, a pill, a decoction, a granule, a capsule, a powder or a tablet; the specific medicine solution is prepared from 30 parts of Xanthium sibiricum, 15 parts of Cnidium monnieri and 15 parts of Dictamni cortex.
3. A Chinese medicine composition for treating dermatitis according to claim 1, characterized in that: The dermatitis includes one or more of eczema, dermatitis, atopic dermatitis, allergic dermatitis, urticaria, and psoriasis. The atopic dermatitis includes simple atopic dermatitis and mixed atopic dermatitis.
4. A method for preparing a Chinese medicine composition for treating dermatitis according to any one of claims 1 to 3, characterized in that: The specific operation steps of the preparation method of the skin disease Chinese medicine composition for dermatitis are: S1. Pretreatment: Select the required medicinal materials according to the Chinese medicine prescription, ensure the quality and source of the medicinal materials, and then accurately weigh each medicinal material according to the weight specified in the prescription; S2. Pretreatment of medicinal materials: Clean the medicinal materials as necessary to remove impurities and dirt on the surface, and then slice or crush the medicinal materials as needed to facilitate decoction or extraction; S3, decoction or extraction: put the pretreated medicinal materials into a decoction pot, add an appropriate amount of water, and then decoct with a slow fire for 10 to 30 minutes to fully dissolve the effective ingredients in the medicinal materials in the water to obtain a decoction liquid. During the decoction process, the heat and time can be adjusted as needed to ensure the extraction effect. At the same time, the crushed honeysuckle is dynamically extracted with petroleum ether, and the extract is filtered to recover the petroleum ether to form a honeysuckle extract; S4, filtering and concentrating: after the decoction is completed, the decoction liquid is cooled to 40 degrees Celsius, the liquid is filtered to remove the residue, and the filtered liquid is concentrated to reduce the volume and increase the concentration to form a concentrated liquid, and the honeysuckle extract is concentrated to obtain a honeysuckle fragrant extract; S5. Formulation: The concentrated liquid medicine is made into different dosage forms, such as decoction, pills, powder or paste, as needed. During the formulation forming process, the stability and effectiveness of the dosage form need to be ensured; S6. Preparation of honeysuckle dew: subjecting the honeysuckle extracted with petroleum ether in step S3 to reflux extraction with ethyl acetate, filtering the extract to recover ethyl acetate, and concentrating the extract to obtain total honeysuckle flavonoids, and then mixing the obtained honeysuckle extract with total honeysuckle flavonoids and performing steam distillation to obtain honeysuckle dew.
5. The method for preparing a skin disease Chinese medicine composition for dermatitis according to claim 4, characterized in that: The decoction pot in step S3 should be a ceramic pot, a casserole or a stainless steel vessel, and avoid using corrosive vessels such as iron and aluminum to avoid chemical reactions with the medicinal materials that affect the efficacy.
6. The method for preparing a Chinese medicine composition for treating dermatitis according to claim 4, characterized in that: The medicinal materials used for decoction in step S3 need to be soaked for a period of time before decoction so that the effective ingredients in the medicinal materials can be better dissolved in water. When decocting, they should be boiled over high heat first, and then decocted over low heat to ensure that the medicinal liquid is fully decocted.
7. The method for preparing a Chinese medicine composition for treating dermatitis according to claim 4, characterized in that: During the preparation molding process in step S5, if it is necessary to add glue or auxiliary materials, it should be ensured that they are compatible with the drug solution and avoid affecting the efficacy of the drug.
Citation Information
Patent Citations
Traditional Chinese medicine composition for treating eczema and dermatitis
CN106728166B