Automated analyzer

Abstract

The present invention relates to an automatic analysis device, which can realize an appropriate transfer action even if the amount of liquid to be transferred from a reaction tube to another reaction tube by using a probe is large. An automatic analyzer includes a transfer mechanism, a first dispensing probe, a second dispensing probe, and a control unit. The transfer mechanism transfers the sample ejection reaction tube and the transfer reaction tube. The first dispensing probe dispenses a mixed solution containing a sample. The second dispensing probe dispenses a reagent or a diluent. When the amount of the mixed liquid to be transferred from the sample discharge reaction tube to the transfer reaction tube exceeds a threshold value, the control unit controls the first dispensing probe such that the first dispensing probe sucks the mixed liquid from the sample discharge reaction tube in a first cycle and discharges the sucked mixed liquid to the transfer reaction tube in a second cycle.

Description

Technical Field

[0001] The embodiments disclosed in this specification and the accompanying drawings relate to an automatic analysis device. Background Art

[0002] Conventionally, an automatic analysis device for qualitative / quantitative analysis of test specimens such as blood and urine has been known. In the case of performing analysis of a double-reagent type, first, a first reagent is dispensed into a reaction tube storing the test specimen. Then, after a predetermined time has elapsed, a second reagent is dispensed into the reaction tube. After a predetermined time has elapsed since the second reagent was dispensed, a predetermined measurement is performed in the measurement unit. The time from when the first reagent is dispensed into the reaction tube until the second reagent is dispensed into the reaction tube and the time from when the second reagent is dispensed into the reaction tube until the measurement in the measurement unit is performed are determined by the operation cycle of a reaction disk that holds the reaction tube and transfers it to each dispensing position and measurement position. For example, the time from when the first reagent is dispensed into the reaction tube until the second reagent is dispensed into the reaction tube can be set to 5 minutes, and the time from when the second reagent is dispensed into the reaction tube until the measurement in the measurement unit is performed can be set to 5 minutes.

[0003] Depending on the type of measurement item, as the measurement time in the measurement unit after the second reagent is dispensed into the reaction tube, it may be desired to ensure a longer time (for example, 10 minutes). For this reason, consideration is given to the timing of dispensing the second reagent into the reaction tube earlier. For example, a test specimen is dispensed into the reaction tube, and the first reagent is dispensed at the timing when the diluent was conventionally dispensed. After that, the test specimen and the reagent in the reaction tube are transferred to another reaction tube using a probe, and the second reagent is dispensed into the reaction tube at the timing when the first reagent was conventionally dispensed. Thus, it is considered that the timing of dispensing the second reagent into the reaction tube can be advanced.

[0004] In an automatic analysis device, generally, the processing time for one cycle is determined. Therefore, there is also an upper limit to the amount of liquid that can be transferred within the processing time for one cycle using a probe. Thus, when the amount of liquid to be transferred using the probe is large, there is a concern that the liquid transfer cannot be completed within one cycle. To solve this problem, consideration is also given to changing the pump connected to the probe to a pump with a higher liquid suction speed and ejection speed, but this may cause a reduction in the measurement stability performance in the automatic analysis device. Summary of the Invention

[0005] One of the problems to be solved by the embodiments disclosed in this specification and the accompanying drawings is to achieve an appropriate transfer operation even when the amount of liquid to be transferred from a reaction tube to another reaction tube using a probe is large. However, the problems to be solved by the embodiments disclosed in this specification and the accompanying drawings are not limited to the above problems. It is also possible to define the problems corresponding to the respective effects of the respective configurations shown in the embodiments described later as other problems.

[0006] The automatic analysis device according to the embodiment includes: a transfer mechanism that transfers a reaction tube for sample ejection and a reaction tube for transfer; a first dispensing probe that dispenses a mixed solution containing a sample; a second dispensing probe that dispenses a reagent or a diluent; and a control unit that controls the first dispensing probe to suck the mixed solution from the reaction tube for sample ejection in a first cycle and eject the sucked mixed solution into the reaction tube for transfer in a second cycle when the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer exceeds a threshold value. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] Figure 1 is a block diagram showing an example of the configuration of the automatic analysis device.

[0008] Figure 2 is a diagram showing an example of the functional configuration of the analysis control unit of the automatic analysis device.

[0009] Figure 3 is a diagram showing an example of the configuration of the analysis unit of the automatic analysis device.

[0010] Figure 4 is a diagram showing an example of the operation timing in the case of performing a dilution operation.

[0011] Figure 5 is a diagram showing an example of the operation timing in the case of measuring an extended reaction time.

[0012] Figure 6 is a flowchart showing an example of the dispensing method according to the present embodiment.

[0013] Figure 7 is a flowchart showing an example of the dispensing method according to the present embodiment.

[0014] Figure 8 is a flowchart showing an example of the dispensing method according to the present embodiment.

[0015] Figure 9 is a diagram showing an example of the setting screen of the automatic analysis device.

[0016] Figure 10 is a diagram showing an example of the setting screen of the automatic analysis device.

[0017] Figure 11 is a diagram showing an example of the setting screen of the automatic analysis device.

[0018] Figure 12 is a diagram showing an example of the setting screen of the automatic analysis device.

[0019] Figure 13This is a diagram showing an example of the setting screen of the automatic analysis device.

[0020] Figure 14 This is a diagram explaining the transfer of the reaction tube by the transfer mechanism.

[0021] Figure 15 This is a diagram explaining the transfer of the reaction tube by the transfer mechanism.

[0022] Figure 16 This is a diagram explaining the transfer of the reaction tube by the transfer mechanism.

[0023] Figure 17 This is a diagram explaining the transfer of the reaction tube by the transfer mechanism.

[0024] Figure 18 This is a diagram showing an example of the operation timing of another example of the automatic analysis device, and is also a diagram showing an example of the operation timing in the case of performing measurement using the third reagent.

[0025] Figure 19 This is a diagram showing an example of the setting screen of the automatic analysis device in the case of performing measurement using the third reagent.

[0026] Figure 20 This is a diagram showing an example of the setting screen of the automatic analysis device in the case of performing measurement using the third reagent. Detailed implementation mode

[0027] Hereinafter, the implementation mode will be described with reference to the accompanying drawings. In addition, in the accompanying drawings attached to this specification, for the convenience of illustration and understanding, the scale, the aspect ratio in the vertical and horizontal directions, etc. are appropriately changed and exaggerated with respect to the actual object.

[0028] Figure 1 This is a block diagram showing an example of the configuration of the automatic analysis device 10. Figure 2 This is a diagram showing an example of the functional configuration of the analysis control unit 11 of the automatic analysis device 10. Figure 3 This is a diagram showing an example of the configuration of the analysis unit 20 of the automatic analysis device 10.

[0029] The automatic analysis device 10 includes an analysis unit 20, an analysis control unit 11, an analysis data processing unit 13, an output unit 15, an operation unit 17, and a system control unit 19. The analysis unit 20 measures and analyzes the test sample or calibration sample. The analysis control unit 11 controls the analysis unit 20. The analysis data processing unit 13 processes the analysis signal output from the analysis unit 20 and calculates the analysis data. The output unit 15 outputs the analysis data from the analysis data processing unit 13. The operation unit 17 accepts the input of analysis conditions or various command signals. The system control unit 19 exercises overall control over these units.

[0030] The analysis data processing unit 13 includes: an arithmetic unit 131 that creates a calibration table, calculates analysis data, etc. based on the calibration signal, analysis signal, etc. output from the analysis unit 20; and a storage unit 132 that stores the calibration table created by the arithmetic unit 131, the calculated analysis data, etc.

[0031] The arithmetic unit 131 creates a calibration table for each item based on the calibration signal of each item output from the analysis unit 20, outputs it to the output unit 15, and stores it in the storage unit 132. In addition, for the analysis signal of each item output from the analysis unit 20, after reading the calibration table corresponding to the item of the analysis signal from the storage unit 132, the arithmetic unit 131 calculates the analysis data using the calibration table, outputs it to the output unit 15, and stores it in the storage unit 132.

[0032] The storage unit 132 includes a hard disk, etc., and stores the calibration table, analysis data, etc. output from the arithmetic unit 131 for each test specimen to be inspected.

[0033] The output unit 15 includes a printing unit 151 that prints and outputs the calibration table, analysis data, etc. output from the analysis data processing unit 13, a display unit 152 that displays and outputs them, and an online unit 153 for outputting analysis data, etc. to an external information system, etc. In addition, the printing unit 151 includes a printer, etc., and prints and outputs the calibration table, analysis data, etc. output from the analysis data processing unit 13 on printing paper based on a preset format. In addition, the display unit 152 includes monitors such as a CRT (Cathode Ray Tube), a liquid crystal display monitor, and an organic EL display monitor, and displays the calibration table, analysis data, etc. output from the analysis data processing unit 13, or displays a screen for setting analysis conditions according to an instruction from the system control unit 19.

[0034] The operation unit 17 includes input devices such as a keyboard, a mouse, buttons, and a touch panel, and performs various operations such as setting analysis conditions, inputting specimen information such as the specimen ID or specimen name of the object to be inspected, selecting measurement items for each test specimen of the object to be inspected, calibration operations for each item, and test specimen analysis operations.

[0035] The system control unit 19 includes a CPU and a storage circuit (not shown). After storing information such as the command signal of the operator, analysis conditions, specimen information, and measurement items for each test specimen provided from the operation unit 17, based on this information, it performs overall system control such as controlling each unit constituting the analysis unit 20 to operate in a specified timing with a certain period, or control related to the creation of the calibration table, calculation and output of analysis data.

[0036] The analysis unit 20 analyzes the test sample. In particular, the analysis unit 20 generates blank data based on blank measurement, generates standard data based on standard measurement, or generates inspected data based on the inspected measurement, etc. The standard measurement is to measure a mixed solution of a standard sample for each inspection item and a reagent used in the analysis of each inspection item, and the inspected measurement is to measure a mixed solution of an inspected sample and a reagent. The analysis unit 20 includes a sample tray 21, a reagent library 22, a reagent library 23, a transfer mechanism (reaction tray) 24, a first dispensing mechanism 25, a second dispensing mechanism 26, a third dispensing mechanism 27, a first stirring mechanism 28, and a second stirring mechanism 29.

[0037] The sample tray 21 holds a plurality of sample containers 31, in which samples such as standard samples, serum, and other inspected samples are stored. The sample container 31 is, for example, placed on a sample tray and held by the sample tray 21. One or more sample containers 31 are placed on one sample tray.

[0038] In the reagent library 22, there is provided a reagent tray 35 that holds a plurality of reagent containers 32 rotatably, and the reagent tray 35 refrigerates and holds the first reagent stored in the reagent container 32. That is, the reagent container 32 stores the first reagent such as single reagent types and double reagent types that react with the components of each inspection item included in the standard sample, the inspected sample, etc. In the reagent library 23, there is provided a reagent tray 36 that holds a plurality of reagent containers 33 rotatably, and the reagent tray 36 refrigerates and holds the second reagent stored in the reagent container 33. That is, the reagent container 33 stores the second reagent paired with the first reagent. In addition, the reagent tray 35 may hold both the reagent container 32 storing the first reagent and the reagent container 33 storing the second reagent.

[0039] The transfer mechanism (reaction tray) 24 holds a plurality of fixing members detachably on the circumference. The fixing members hold a plurality of reaction tubes 41, 42 at a predetermined interval in an arc shape. That is, the transfer mechanism 24 mounts a plurality of fixing members as fixing members for the plurality of reaction tubes 41, 42 and holds the plurality of reaction tubes 41, 42 so as to be movable.

[0040] The first dispensing mechanism 25 includes a first dispensing probe 251, an arm, and a cleaning tank. The first dispensing probe 251 attracts the sample stored in the sample container 31 held by the sample tray 21 and performs dispensing by spraying it into the reaction tube 41. In addition, the first dispensing probe 251 attracts the mixed solution stored in the reaction tube 41 and performs dispensing by spraying it into the reaction tube 42. The arm holds the first dispensing probe 251 so as to be rotatable and vertically movable. Each time the dispensing of one sample from the first dispensing probe 251 is completed, the cleaning tank cleans the first dispensing probe 251.

[0041] The second reagent dispensing mechanism 26 includes a second reagent dispensing probe 261, an arm, and a cleaning bath. The second reagent dispensing probe 261 sucks and holds the first reagent in the reagent container 32 held on the reagent holder 35, and performs reagent dispensing by ejecting the first reagent into the reaction tubes 41 and 42 into which the specimen has been ejected. The second reagent dispensing probe 261 may also suck the diluent and perform reagent dispensing by ejecting the diluent into the reaction tubes 41 and 42 into which the specimen has been ejected. The arm holds the second reagent dispensing probe 261 so as to be rotatable and vertically movable. Each time the dispensing of one reagent from the second reagent dispensing probe 261 is completed, the cleaning bath cleans the second reagent dispensing probe 261.

[0042] The third reagent dispensing mechanism 27 includes a third reagent dispensing probe 271, an arm, and a cleaning bath. The third reagent dispensing probe 271 sucks and holds the second reagent in the reagent container 33 held on the reagent holder 36, and performs reagent dispensing by ejecting it into the reaction tubes 41 and 42. The arm holds the third reagent dispensing probe 271 so as to be rotatable and vertically movable. Each time the dispensing of one reagent from the third reagent dispensing probe 271 is completed, the cleaning bath cleans the third reagent dispensing probe 271.

[0043] The first stirring mechanism 28 includes a stirring member, an arm, and a cleaning bath. The stirring member stirs the mixture of the specimen and the first reagent dispensed into the reaction tubes 41 and 42. The arm holds the stirring member so as to be rotatable and vertically movable. The cleaning bath cleans the stirring member each time the stirring of the mixture is completed.

[0044] The second stirring mechanism 29 includes a stirring member, an arm, and a cleaning bath. The stirring member stirs the mixture of the specimen, the first reagent, and the second reagent dispensed into the reaction tubes 41 and 42. The arm holds the stirring member so as to be rotatable and vertically movable. The cleaning bath cleans the stirring member each time the stirring of the mixture is completed.

[0045] In addition, the automatic analyzer 10 further includes a reaction tube cleaning mechanism 38 and a measurement unit 39. The measurement unit 39 measures the light that has passed through the reaction tubes 41 and 42 among the light irradiated to the reaction tubes 41 and 42 containing solutions such as stored water and the mixture. The reaction tube cleaning mechanism 38 performs a cleaning process, which is to clean and dry the inside of the reaction tubes 41 and 42 after the measurement of the mixture by the measurement unit 39. In addition, the reaction tube cleaning mechanism 38 ejects a blank solution, which is a liquid such as pure water, into the cleaned reaction tubes 41 and 42 for blank measurement.

[0046] In addition, the measurement unit 39 generates blank data through blank measurement by detecting the light transmitted through the reaction tubes 41 and 42 filled with the blank liquid. In addition, the measurement unit 39 generates standard data through standard measurement by detecting the light transmitted through the mixed liquid in the reaction tubes 41 and 42 filled with the standard sample and the reagent. Furthermore, the measurement unit 39 generates measured data through the measurement of the sample by detecting the light transmitted through the mixed liquid in the reaction tubes 41 and 42 filled with the test sample and the reagents 51 and 52.

[0047] The analysis control unit 11 controls various components of the analysis unit 20. For example, for inspection, the analysis control unit 11 sequentially distributes the inspection items input for each test sample into the reaction tubes 41 and 42 that have been cleaned by the reaction tube cleaning mechanism 38. Then, the reaction tube cleaning mechanism 38 sprays the blank liquid with the combined volume obtained by adding the dispensed volume of the sample and the dispensed volumes of the reagents 51 and 52, which is set to the analysis parameters for the inspection item, into the reaction tubes 41 and 42 to which the inspection items have been distributed. Next, the measurement unit 39 performs blank measurement on the reaction tubes 41 and 42 after the blank liquid has been sprayed and generates blank data.

[0048] The analysis control unit 11 includes a control circuit 110, a storage circuit 118, and a drive mechanism 120. The drive mechanism 120 drives the analysis unit 20 according to the control of the control circuit 110. The drive mechanism 120 is implemented by, for example, gears, stepping motors, conveyor belts, and lead screws. The drive mechanism 120 individually rotates and drives, for example, the sample tray 21, the reagent tray 35, and the reagent tray 36 to move the sample container 31, the reagent container 32, and the reagent container 33, respectively. In addition, the drive mechanism 120 rotationally drives the transfer mechanism (reaction disk) 24 to move the reaction tubes 41 and 42. Moreover, the drive mechanism 120 individually drives the above-mentioned respective arms up and down and rotates them to move the first dispensing probe 251 and the second dispensing probe 261, respectively.

[0049] The storage circuit 118 stores at least a program for implementing the functions of the control circuit 110. In addition to storing the program for implementing the functions of the control circuit 110, the storage circuit 118 may also store other programs, data input via the operation unit 17, other information such as data generated by the analysis unit 20, etc. The storage circuit 118 includes a magnetic or optical recording medium or a recording medium such as a semiconductor memory that can be read by a processor. In addition, the storage circuit 118 does not necessarily have to be implemented by a single storage device. For example, the storage circuit 118 may also be implemented by multiple storage devices.

[0050] The control circuit 110 is a processor that functions as the center of the automatic analysis device 10. The control circuit 110 realizes functions corresponding to the executed program by executing the program stored in the storage circuit 118. In addition, the control circuit 110 may also have a storage area for storing at least a part of the data stored in the storage circuit 118. Figure 2 The control circuit 110 shown realizes, for example, a first dispensing function 111, a second dispensing function 112, a reaction tube transfer function 113 for sample ejection, and a reaction tube transfer function 114 for transfer by executing the program stored in the storage circuit 118. In addition, in the present embodiment, the case where the first dispensing function 111, the second dispensing function 112, the reaction tube transfer function 113 for sample ejection, and the reaction tube transfer function 114 for transfer are realized by a single processor is described, but it is not limited thereto. For example, a control circuit may be configured by combining a plurality of independent processors, and the above various functions may be realized by each processor executing a program.

[0051] In each embodiment of the present specification, the first dispensing function 111 of the control circuit 110 constitutes a first dispensing unit, the second dispensing function 112 constitutes a second dispensing unit, the reaction tube transfer function 113 for sample ejection constitutes a reaction tube transfer unit for sample ejection, and the reaction tube transfer function 114 for transfer constitutes a reaction tube transfer unit for transfer.

[0052] The first dispensing function 111 is a function of controlling the first dispensing probe 251 and dispensing a mixed solution containing a reagent into the reaction tube. For example, in the first dispensing function 111, the control circuit 110 controls the first dispensing probe 251 so that the first dispensing probe 251 dispenses the mixed solution containing the sample from the reaction tube 41 for sample ejection to the reaction tube 42 for transfer.

[0053] The second dispensing function 112 is a function of controlling the second dispensing probe 261 and dispensing a reagent or a diluent into the reaction tube. For example, in the second dispensing function 112, the control circuit 110 controls the second dispensing probe 261 so that the second dispensing probe 261 dispenses at least one of the first reagent stored in the reagent container 32 and the second reagent stored in the reagent container 33 into at least one of the reaction tubes 41 and 42. In addition, in the second dispensing function 112, the control circuit 110 may also control the second dispensing probe 261 so that the second dispensing probe 261 dispenses the diluent into at least one of the reaction tubes 41 and 42.

[0054] The reaction tube transfer function 113 for sample ejection is a function of controlling the transfer mechanism (reaction disk) 24 and transferring the reaction tube 41 for sample ejection. For example, in the reaction tube transfer function 113 for sample ejection, the control circuit 110 controls the transfer mechanism 24 so that the transfer mechanism 24 transfers the reaction tube 41 for sample ejection from the second dispensing position 242 described later to the suction position 245.

[0055] The transfer reaction tube transfer function 114 is a function of controlling the transfer mechanism (reaction disk) 24 to transfer the transfer reaction tube 42. For example, in the transfer reaction tube transfer function 114, the control circuit 110 controls the transfer mechanism 24 so that the transfer mechanism 24 transfers the transfer reaction tube 42 from the first dispensing position 241 to the second dispensing position 242.

[0056] Next, embodiments of the present disclosure will be described with reference to the drawings. In the present embodiment, as the reaction tubes 41 and 42, a sample ejection reaction tube 41 and a transfer reaction tube 42 are used.

[0057] The automatic analyzer 10 intermittently transfers the reaction tubes 41 and 42 held by the transfer mechanism 24 by repeatedly moving (rotating) and stopping the transfer mechanism 24. During the period when the transfer mechanism 24 stops, various processes are performed on the reaction tubes 41 and 42. Examples of the processes for the reaction tubes 41 and 42 include ejecting liquids such as samples, reagents, and diluents into the reaction tubes 41 and 42, sucking liquids from the reaction tubes 41 and 42, stirring the liquids in the reaction tubes 41 and 42, and measuring the liquids in the reaction tubes 41 and 42. One movement and one stop in the transfer mechanism 24 constitute one cycle.

[0058] In the automatic analyzer 10 of the present embodiment, it is configured that the transfer mechanism 24 moves about one week through 5 cycles. That is, the reaction tubes 41 and 42 stop every about 1 / 5 week to receive processing. In addition, it is not necessary to perform processing on the reaction tubes 41 and 42 in all cycles. That is, there may also be cycles in which no processing is performed on the reaction tubes 41 and 42 during the stop period. In addition, the automatic analyzer 10 is not limited to moving the transfer mechanism 24 about one week through 5 cycles. The automatic analyzer 10 may also be configured to move the transfer mechanism 24 about one week through 1 to 4 cycles, or may be configured to move the transfer mechanism 24 about one week through 6 or more cycles.

[0059] In the present embodiment, after 5 cycles, the reaction tubes 41 and 42 move from the original position to a position advanced by the amount of one reaction tube. Therefore, the reaction tubes 41 and 42 advance by the amount of one reaction tube in the forward direction (downstream side) of the moving direction every 5 cycles (about one week). In addition, not limited to this, the reaction tubes 41 and 42 may also move from the original position to a position advanced by the amount of two or more reaction tubes every prescribed number of cycles equivalent to about one week (5 cycles in the present embodiment). In addition, the reaction tubes 41 and 42 may also move from the original position to a retracted position every prescribed number of cycles equivalent to about one week.

[0060] Figure 4This is a diagram showing an example of the operation timing of the automatic analysis device 10 when performing a dilution operation. In Figure 4 In the example shown, the sample is dispensed into the reaction tube 41 for sample ejection, and after one cycle, the diluent is dispensed into the reaction tube 41 for sample ejection. Five cycles after the dispensing of the sample (about one week later), the mixture of the sample and the diluent is transferred from the reaction tube 41 for sample ejection to the transfer reaction tube 42. After another cycle, the first reagent is dispensed into the transfer reaction tube 42. Approximately five minutes after the dispensing of the first reagent, the second reagent is dispensed into the transfer reaction tube 42. Approximately five minutes after the dispensing of the second reagent, the measurement is performed by the measurement unit 39. Therefore, in Figure 4 In the example shown, the reaction time from the dispensing of the second reagent to the measurement by the measurement unit 39 is about five minutes.

[0061] However, depending on the type of measurement item, it may be desired to ensure a longer time as the measurement time in the measurement unit 39 from the dispensing of the second reagent into the reaction tube. Therefore, consideration is given to performing reaction time extension measurement to extend the reaction time by advancing the timing of dispensing the second reagent into the reaction tube. Figure 5 This is a diagram showing an example of the operation timing of the automatic analysis device 10 when performing reaction time extension measurement.

[0062] In Figure 5 In the example shown, the first reagent is dispensed at the timing of dispensing the diluent in the example shown in Figure 4 . In addition, the second reagent is dispensed at the timing of dispensing the first reagent in the example shown in Figure 4 . Specifically, the sample is dispensed into the reaction tube 41 for sample ejection, and after one cycle, the first reagent is dispensed into the reaction tube 41 for sample ejection. Five cycles after the dispensing of the first reagent (about one week later), the mixture of the sample and the first reagent is transferred from the reaction tube 41 for sample ejection to the transfer reaction tube 42. After another cycle, the second reagent is dispensed into the transfer reaction tube 42. Approximately ten minutes after the dispensing of the second reagent, the measurement is performed by the measurement unit 39. Therefore, in Figure 5 In the example shown, the reaction time from the dispensing of the second reagent to the measurement by the measurement unit 39 is about ten minutes. Thus, without changing the time from the dispensing of the sample into the reaction tube 41 for sample ejection to the measurement by the measurement unit 39, it is possible to extend the reaction time from the dispensing of the second reagent to the measurement by the measurement unit 39.

[0063] Next, with reference to Figures 6 to 17 , this reaction time extension measurement will be described in detail. Figures 6 to 8 This is a flowchart showing an example of the dispensing method of the present embodiment. Figures 9 to 13 This is a diagram showing an example of the setting screen of the automatic analysis device 10.Figures 14 to 17 This is a diagram for explaining the transfer of reaction tubes 41 and 42 based on the transfer mechanism 24. Figures 14 to 17 The transfer mechanism 24 is shown as viewed from above.

[0064] In this embodiment, first, the user inputs parameters for each measurement item (step S1). The control unit 11 accepts the input from the user via the operation unit 17. Figure 9 An example of the item list screen is shown. In Figure 9 "Item 1" to "Item 9", the specific measurement item names are actually displayed. When the test subject is blood, the measurement items can also be, for example, red blood cell count, white blood cell count, platelet count, albumin, ALP, LDH, AST, GLB, γ-GTP, etc. The user selects the item for which parameters should be input from the items displayed on the item list screen.

[0065] Figure 10 An example of the parameter input screen is shown. In Figure 10 As an example of the parameter input screen, a measurement type selection screen is shown. In this input screen, if the user selects "Measurement with Extended Reaction Time", the measurement with extended reaction time is performed according to the Figure 5 shown operation timing. Additionally, in this input screen, if the user selects a parameter other than "Measurement with Extended Reaction Time", the measurement is performed according to the Figure 4 shown operation timing.

[0066] Figure 11 An example of the threshold setting screen during the transfer operation is shown. In this setting screen, the user can set the threshold for the amount of the mixed solution during the transfer operation (step S2). The threshold for the amount of the mixed solution can also be set in the setting screen for each measurement item. That is, the threshold for the amount of the mixed solution can also be set for each measurement item. This setting screen can be configured such that the user can input the desired threshold, or it can be configured such that the user selects the desired threshold from multiple options. Additionally, but not limited to this, the threshold for the amount of the mixed solution during the transfer operation can also be fixed to a specified value.

[0067] Figure 12 An example of the dispensing setting screen in the second dispensing probe 261 is shown. In Figure 12In the displayed screen, it is possible to set which one of the first reagent and the diluent is to be dispensed by the second dispensing probe 261 in the subsequent step S14. In this case, the control unit controls the second dispensing probe 261 based on the user's setting so that the second dispensing probe 261 dispenses one of the reagent and the diluent. Similarly, it is also possible to set which one of the first reagent and the second reagent is to be dispensed by the second dispensing probe 261 in the subsequent step S18. In this case, the control unit controls the second dispensing probe 261 based on the user's setting so that the second dispensing probe 261 dispenses one of the first reagent and the second reagent.

[0068] After inputting the parameters for each measurement item, the user creates measurement request information and instructs the automatic analyzer 10 to execute the measurement. Figure 13 An example of the measurement request screen is shown. In Figure 13 the example shown, the specimen ID and the patient name are input, and the items to be measured are selected from among the items displayed in "Measurement Items". In Figure 13 as an example, "Item 1", "Item 2", "Item 4", and "Item 6" are selected as the items to be measured. Thus, the user can create measurement request information by combining the measurement items (step S3). In addition, the input of the patient name can be omitted. In addition, it is also possible to set which one of the reagent and the diluent is to be dispensed using the second dispensing probe 261 in the measurement request screen for each measurement item.

[0069] If the execution of the measurement is instructed, the control unit 11 calculates the amount of the mixed solution to be transferred from the reaction tube 41 for sample ejection to the transfer reaction tube 42 based on the input parameters, and determines whether the amount of the mixed solution exceeds a set threshold value (step S4). In step S4, when it is determined that the amount of the mixed solution is equal to or less than the set threshold value (in the case of "No" in step S4), the process proceeds to Figure 6 process "A" (refer to Figure 7 ). In addition, in step S4, when it is determined that the amount of the mixed solution exceeds the set threshold value (in the case of "Yes" in step S4), the process proceeds to Figure 6 process "B" (refer to Figure 8 ).

[0070] The transfer mechanism 24, the first dispensing probe 251, and the second dispensing probe 261 are respectively controlled by the control circuit 110 via the drive mechanism 120.

[0071] In the present embodiment, the reagent container 32 storing the first reagent and the reagent container 33 storing the second reagent are held in the reagent tray 35 of the reagent storage 22. Moreover, the second dispensing probe 261 is configured to be able to suck the first reagent and be able to suck the second reagent.

[0072] The transfer mechanism 24 transfers a plurality of reaction tubes 41 and 42. In particular, the plurality of reaction tubes 41 and 42 are separated by a predetermined interval and held in an arc shape. In the present embodiment, the transfer mechanism 24 can hold the reaction tube 41 for sample ejection and the transfer reaction tube 42. In Figures 14 to 17 the example shown, the transfer mechanism 24 transfers the plurality of reaction tubes 41 and 42 counterclockwise.

[0073] The transfer mechanism 24 is provided with a first dispensing position 241, a second dispensing position 242, and a suction position 245. The first dispensing position 241 is a position where the mixed solution is dispensed into the transfer reaction tube 42 by the first dispensing probe 251. The second dispensing position 242 is a position where the reagents 51 and 52 sucked from the reagent containers 32 and 33 are dispensed into the reaction tubes 41 and 42 by the second dispensing probe 261 of the second dispensing mechanism 26. In addition, at the second dispensing position 242, the dilution solution can also be dispensed into the reaction tube 41 for sample ejection by the second dispensing probe 261. The suction position 245 is a position for sucking the mixed solution stored in the reaction tube 41 for sample ejection by the first dispensing probe 251.

[0074] In Figures 14 to 17 the example shown, the suction position 245 and the first dispensing position 241 are adjacent in the transfer direction (circumferential direction of the reaction disk 24) of the transfer mechanism 24. In addition, it is not limited thereto, and the suction position 245 and the first dispensing position 241 may not be adjacent in the transfer direction. In the illustrated example, the first dispensing position 241 is located on the rear side (upstream side) in the transfer direction of the transfer mechanism 24 with respect to the suction position 245. In addition, it is not limited thereto, and the first dispensing position 241 may be located on the front side in the transfer direction of the transfer mechanism 24 with respect to the suction position 245. In the present embodiment, the first dispensing probe 251 is configured to be able to enter the sample container 31 held on the sample disk 21, the reaction tube 41 for sample ejection located at the suction position 245, and the transfer reaction tube 42 located at the first dispensing position 241.

[0075] The transfer mechanism 24 rotates about 1 / 5 of a circle in one cycle and about 1 circle in 5 cycles. However, the reaction tubes 41 and 42 held by the transfer mechanism 24 are arranged at a position shifted by one in the transfer direction from the original position after 5 cycles. In the illustrated example, the reaction tubes 41 and 42 held by the transfer mechanism 24 are arranged at a position shifted by one to the front side (downstream side) in the transfer direction from the original position after 5 cycles. That is, every about 1 week, the positions of the reaction tubes 41 and 42 are each shifted by one in the transfer direction.

[0076] Refer to Figure 7 and Figures 14 to 16, the operation of the automatic analysis device 10 in the case where the determination in step S4 is "No" will be described. In the case where the determination in step S4 is "No", that is, when the control unit 11 determines that the amount of the mixed solution to be transferred from the reaction tube 41 for sample ejection to the reaction tube 42 for transfer is equal to or less than the threshold value, the control unit 11 controls the first dispensing probe 251 so that the first dispensing probe 251 sucks the mixed solution from the reaction tube 41 for sample ejection in a single cycle and ejects the sucked mixed solution into the reaction tube 42 for transfer.

[0077] In the present embodiment, first, the reaction tube 41 for sample ejection is disposed at the first dispensing position 241 (refer to step S11, Figure 14 ). Next, at the first dispensing position 241, the sample is dispensed into the reaction tube 41 for sample ejection by using the first dispensing probe 251 (step S12). In the present embodiment, the dispensing of the sample is controlled and executed by the first dispensing function 111 of the control circuit 110. More specifically, in this step S12, first, the first dispensing probe 251 moves toward the sample container 31 held on the sample tray 21 and sucks a predetermined amount of the sample from the sample container 31. Next, the first dispensing probe 251 moves toward the reaction tube 41 for sample ejection located at the first dispensing position 241 and ejects (dispenses) the sample held in the first dispensing probe 251 into the reaction tube 41 for sample ejection. Thus, the sample is held in the reaction tube 41 for sample ejection.

[0078] Next, the reaction tube 41 for sample ejection is transferred to the second dispensing position 242 by using the transfer mechanism 24 (refer to step S13, Figure 15 ). In the present embodiment, the transfer of the reaction tube 41 for sample ejection is controlled and executed by the reaction tube transfer function 113 of the control circuit 110. In the illustrated example, after one cycle from step S11, the reaction tube 41 for sample ejection is located at the second dispensing position 242.

[0079] Thereafter, at the second dispensing position 242, the first reagent is dispensed into the reaction tube 41 for sample ejection by using the second dispensing probe 261 (step S14). Thus, in the present embodiment, Figure 4The timed dispensing of the dispensing diluent in the illustrated example is the first reagent. In the present embodiment, the dispensing of the first reagent is controlled and executed by the second dispensing function 112 of the control circuit 110. More specifically, in this step S14, first, the second dispensing probe 261 moves toward the reagent container 32 held by the reagent carrier 35 of the reagent library 22, and aspirates a predetermined amount of the first reagent from the reagent container 32. Next, the second dispensing probe 261 moves toward the reaction tube 41 for sample ejection located at the second dispensing position 242, and ejects (dispenses) the first reagent held in the second dispensing probe 261 into the reaction tube 41 for sample ejection. Thus, a mixed solution of the sample and the first reagent is held in the reaction tube 41 for sample ejection.

[0080] After that, the reaction tube 41 for sample ejection is transferred by the transfer mechanism 24 by an amount for one cycle, and the sample and the first reagent in the reaction tube 41 for sample ejection are stirred by the first stirring mechanism 28.

[0081] Next, the reaction tube 41 for sample ejection is transferred to the aspiration position 245 by the transfer mechanism 24 (refer to step S15, Figure 16 ). In the present embodiment, the transfer of the reaction tube 41 for sample ejection is controlled and executed by the reaction tube transfer function 113 for sample ejection of the control circuit 110. In the illustrated example, after 4 cycles from step S13, the reaction tube 41 for sample ejection is located at the second dispensing position 242.

[0082] Next, within one cycle, the mixed solution in the reaction tube 41 for sample ejection is transferred to the transfer reaction tube 42 by the first dispensing probe 251 (step S16). Specifically, the mixed solution is aspirated from the reaction tube 41 for sample ejection by the first dispensing probe 251, and the aspirated mixed solution is ejected into the transfer reaction tube 42. In the present embodiment, the transfer of the mixed solution is controlled and executed by the first dispensing function 111 of the control circuit 110.

[0083] Next, the transfer reaction tube 42 is transferred to the second dispensing position 242 by the transfer mechanism 24 (step S17). In the present embodiment, the transfer of the transfer reaction tube 42 is controlled and executed by the transfer reaction tube transfer function 114 of the control circuit 110. In the illustrated example, after one cycle from step S16, the transfer reaction tube 42 is located at the second dispensing position 242.

[0084] After that, at the second dispensing position 242, the second reagent is dispensed into the transfer reaction tube 42 by the second dispensing probe 261 (step S18). Thus, in the present embodiment, in Figure 4In the example shown, the second reagent is dispensed at a timed interval after the first reagent is dispensed. After the second dispensing probe 261 aspirates the second reagent, the second dispensing probe 261 moves toward the transfer reaction tube 42 located at the second dispensing position 242, and ejects (dispenses) the second reagent held in the second dispensing probe 261 into the transfer reaction tube 42. Thus, the first reagent, the second reagent, and the sample are held in the transfer reaction tube 42. In the present embodiment, the dispensing of the second reagent is controlled and executed by the second dispensing function 112 of the control circuit 110.

[0085] In a subsequent cycle, the first reagent, the second reagent, and the sample in the transfer reaction tube 42 are stirred by the stirring mechanism 29, and after a predetermined time (e.g., 10 minutes), measurement is performed by the measurement unit 39.

[0086] Next, with reference to Figure 8 and Figure 14 、 Figure 15 and Figure 17 , the operation of the automatic analyzer 10 when the determination in step S4 is "Yes" will be described. Steps S11 to S15 are the same as steps S11 to S15 described with reference to Figure 7 , and thus detailed description thereof is omitted.

[0087] When the determination in step S4 is "Yes", that is, when the control unit 11 determines that the amount of the mixed solution to be transferred from the sample ejection reaction tube 41 to the transfer reaction tube 42 exceeds the threshold, the control unit 11 controls the first dispensing probe 251 so that the first dispensing probe 251 aspirates the mixed solution from the sample ejection reaction tube 41 in the first cycle and ejects the aspirated mixed solution into the transfer reaction tube 42 in the second cycle.

[0088] After the sample ejection reaction tube 41 is disposed at the aspiration position 245 in step S15, the first dispensing probe 251 aspirates the mixed solution from the sample ejection reaction tube 41 (step S21). In the present embodiment, the aspiration of the mixed solution is controlled and executed by the first dispensing function 111 of the control circuit 110.

[0089] Next, the transfer reaction tube 42 is transferred by the transfer mechanism 24, and the transfer reaction tube 42 is disposed at the first dispensing position 241 (step S22). In the present embodiment, the transfer of the transfer reaction tube 42 is controlled and executed by the transfer reaction tube transfer function 114 of the control circuit 110. In the illustrated example, one cycle after step S22, the transfer reaction tube 42 is located at the first dispensing position 241.

[0090] Thereafter, using the first dispensing probe 251, the mixed solution aspirated in step S21 is ejected (dispensed) into the transfer reaction tube 42 located at the first dispensing position 241 (step S23).

[0091] Next, the transfer reaction tube 42 is transferred to the second dispensing position 242 by the transfer mechanism 24 (step S24). In the present embodiment, the transfer of the transfer reaction tube 42 is controlled and executed by the transfer reaction tube transfer function 114 of the control circuit 110. In the illustrated example, after one cycle from step S23, the transfer reaction tube 42 is located at the second dispensing position 242.

[0092] Thereafter, at the second dispensing position 242, a second reagent is dispensed into the transfer reaction tube 42 by the second dispensing probe 261 (step S25). Also in this case, the second reagent is dispensed at the timing of dispensing the first reagent in the illustrated example. After aspirating the second reagent using the second dispensing probe 261, the second dispensing probe 261 moves to the transfer reaction tube 42 located at the second dispensing position 242, and the second reagent held in the second dispensing probe 261 is ejected (dispensed) into the transfer reaction tube 42. Thus, the first reagent, the second reagent, and the sample are held in the transfer reaction tube 42. In the present embodiment, the dispensing of the second reagent is controlled and executed by the second dispensing function 112 of the control circuit 110. Figure 4 In subsequent cycles, the first reagent, the second reagent, and the sample in the transfer reaction tube 42 are stirred by the stirring mechanism 29, and after a predetermined time (e.g., 10 minutes), measurement is performed by the measurement unit 39.

[0093] The automatic analyzer 10 of the present embodiment includes: a transfer mechanism 24 for transferring the sample ejection reaction tube 41 and the transfer reaction tube 42; a first dispensing probe 251 for dispensing the mixed solution containing the sample; a second dispensing probe 261 for dispensing a reagent or a diluent; and a control unit 11. When the amount of the mixed solution to be transferred from the sample ejection reaction tube 41 to the transfer reaction tube 42 exceeds a threshold value, the control unit 11 controls the first dispensing probe 251 so that the first dispensing probe 251 aspirates the mixed solution from the sample ejection reaction tube 41 in the first cycle and ejects the aspirated mixed solution into the transfer reaction tube 42 in the second cycle.

[0094] In the automatic analyzer 10 of the present embodiment, when the amount of the mixed solution to be transferred from the sample ejection reaction tube 41 to the transfer reaction tube 42 is equal to or less than the threshold value, the control unit 11 controls the first dispensing probe 251 so that the first dispensing probe 251 aspirates the mixed solution from the sample ejection reaction tube 41 in a single cycle and ejects the aspirated mixed solution into the transfer reaction tube 42.

[0095] ​

[0096] In the automatic analysis device 10 of the present embodiment, the control unit 11 controls the second dispensing probe 261 based on the user's setting so that the second dispensing probe 261 dispenses either the reagent or the diluent.

[0097] In the automatic analysis device 10 of the present embodiment, the control unit 11 controls the second dispensing probe 261 based on the user's setting so that the second dispensing probe 261 dispenses either the first reagent or the second reagent.

[0098] The automatic analysis device 10 of the present embodiment has a function of setting a threshold value for each measurement item.

[0099] The automatic analysis device 10 of the present embodiment has a function of setting which one of the reagent and the diluent is to be dispensed using the second dispensing probe 261.

[0100] The automatic analysis device 10 of the present embodiment has a function of setting which one of the first reagent and the second reagent is to be dispensed using the second dispensing probe 261.

[0101] The automatic analysis device 10 of the present embodiment has a function of setting a threshold value in the setting screen for each measurement item.

[0102] The automatic analysis device 10 of the present embodiment has a function of setting which one of the reagent and the diluent is to be dispensed using the second dispensing probe 261 in the measurement order screen for each measurement item.

[0103] The method for transferring the mixed solution in the automatic analysis device 10 of the present embodiment is a method for transferring the mixed solution in an automatic analysis device, the automatic analysis device including: a transfer mechanism for transferring the reaction tube for ejecting the sample and the reaction tube for transfer; a first dispensing probe for dispensing the mixed solution containing the sample; and a second dispensing probe for dispensing the reagent or the diluent, the transfer method including the following transfer steps: when the amount of the mixed solution to be transferred from the reaction tube for ejecting the sample to the reaction tube for transfer exceeds the threshold value, sucking the mixed solution from the reaction tube for ejecting the sample in the first cycle and ejecting the sucked mixed solution into the reaction tube for transfer in the second cycle.

[0104] The method for transferring the mixed solution in the automatic analysis device 10 of the present embodiment includes the following other transfer steps: when the amount of the mixed solution to be transferred from the reaction tube for ejecting the sample to the reaction tube for transfer is less than or equal to the threshold value, sucking the mixed solution from the reaction tube for ejecting the sample in a single cycle and ejecting the sucked mixed solution into the reaction tube for transfer.

[0105] The method for transferring the mixed solution in the automatic analysis device 10 of the present embodiment includes the following determination step before the transfer step: the control unit of the automatic analysis device determines whether the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer exceeds the threshold value.

[0106] According to such an automatic analysis device 10 and the method for transferring the mixed solution in the automatic analysis device 10, even when the amount of the mixed solution to be transferred from the reaction tube 41 for sample ejection to the reaction tube 42 for transfer is large and it is impossible to complete the suction of the mixed solution from the reaction tube 41 for sample ejection and the ejection of the mixed solution to the reaction tube 42 for transfer within one cycle, an appropriate transfer operation can be achieved. In particular, when the amount of the mixed solution to be transferred is relatively large, by controlling the first dispensing probe 251 so that the first dispensing probe 251 sucks the mixed solution from the reaction tube 41 for sample ejection in the first cycle and ejects the sucked mixed solution to the reaction tube 42 for transfer in the second cycle, an appropriate transfer operation can be achieved.

[0107] Various modifications can be made to the above-described embodiment. Hereinafter, other embodiments will be described while appropriately referring to the drawings. In the following description and the drawings used in the following description, for the parts that can be configured in the same manner as those in the above-described embodiment, the same reference numerals as those used for the corresponding parts in the above-described embodiment are used, and the repeated description is omitted.

[0108] Figure 18 It is a diagram showing an example of the operation timing of another example of the automatic analysis device 10, and is a diagram showing an example of the operation timing in the case of performing measurement using a third reagent. Figure 19 and Figure 20 It is a diagram showing an example of the setting screen of the automatic analysis device 10 in the case of performing measurement using a third reagent.

[0109] In Figure 18 the example shown, the first reagent is dispensed at the timing of dispensing the dilution liquid in Figure 4 the example shown. In addition, the second reagent is dispensed at the timing of dispensing the first reagent in Figure 4 the example shown. Moreover, in Figure 4In the example shown, the third reagent is dispensed at a timed interval after the second reagent is dispensed in portions. Specifically, the sample is dispensed into the reaction tube 41 for sample ejection, and after one cycle, the first reagent is dispensed into the reaction tube 41 for sample ejection. After 5 cycles (about 1 week) from the dispensing of the first reagent, the mixture of the sample and the first reagent is transferred from the reaction tube 41 for sample ejection to the transfer reaction tube 42. After another cycle, the second reagent is dispensed into the transfer reaction tube 42. Approximately 5 minutes after the dispensing of the second reagent, the third reagent is dispensed into the transfer reaction tube 42. Approximately 5 minutes after the dispensing of the third reagent, the measurement is performed by the measurement unit 39. Therefore, in Figure 18 the example shown, it is possible to perform the measurement using three reagents without changing the time from dispensing the sample into the reaction tube 41 for sample ejection until the measurement unit 39 performs the measurement.

[0110] Figure 19 An example of the input screen for the parameters in this modified example is shown. Figure 19 Corresponding to the input screen for the parameters described with reference to Figure 10 in the above-described embodiment. In Figure 19 , as an example of the input screen for the parameters, a selection screen for the measurement type is shown. On this input screen, if the user selects "Measurement using the third reagent", the measurement using the third reagent is performed according to the Figure 18 shown operation timing. Additionally, on this input screen, if the user selects parameters other than "Measurement using the third reagent", the measurement is performed according to the Figure 4 or Figure 5 shown operation timing.

[0111] As another modified example, the third dispensing probe 271 of the third dispensing mechanism 27 can also suck the third reagent and perform the dispensing by ejecting it into the reaction tubes 41 and 42 storing the sample or the mixture. Therefore, the control circuit 110 can also have a third dispensing function. The third dispensing function is implemented by executing the program stored in the storage circuit 118. The third dispensing function is the function of controlling the third dispensing probe 271 to dispense the third reagent into the reaction tubes 41 and 42. For example, in the third dispensing function, the control circuit 110 controls the third dispensing probe 271 so that the third dispensing probe 271 dispenses the third reagent stored in the reagent container into at least one of the reaction tubes 41 and 42. Additionally, the third dispensing function can also constitute the third dispensing unit.

[0112] In Figure 9 the example shown, the user can also call up the screen for editing the parameters of the existing items and the screen for inputting the parameters for the newly added items from the item list screen.

[0113] In Figure 12In the example shown, for instance, when "diluent" is selected in "type", aliquoting is performed according to the Figure 4 action timing sequence shown, and when "first reagent" is selected in "type", aliquoting is performed according to the Figure 5 action timing sequence shown.

[0114] In addition, in the example shown in Figure 12 it is also possible to select one from the three types of "diluent", "first reagent", and "second reagent" in the item of "type".

[0115] The preferred mode in the present embodiment is shown below. [1]

[0117] An automatic analysis device, comprising:

[0118] a transfer mechanism for transferring a reaction tube for sample ejection and a reaction tube for transfer;

[0119] a first aliquoting probe for aliquoting a mixed solution containing a sample;

[0120] a second aliquoting probe for aliquoting a reagent or a diluent; and

[0121] a control unit that, when the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer exceeds a threshold value, controls the first aliquoting probe so that the first aliquoting probe aspirates the mixed solution from the reaction tube for sample ejection in a first cycle and ejects the aspirated mixed solution into the reaction tube for transfer in a second cycle. [2]

[0123] According to the automatic analysis device described in [1], when the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer is below the threshold value, the control unit controls the first aliquoting probe so that the first aliquoting probe aspirates the mixed solution from the reaction tube for sample ejection in a single cycle and ejects the aspirated mixed solution into the reaction tube for transfer. [3]

[0125] According to the automatic analysis device described in [1] or [2], the control unit controls the second aliquoting probe based on the user's setting so that the second aliquoting probe aliqouts one of the reagent and the diluent. [4]

[0127] According to the automatic analysis device described in any one of [1] to [3], the control unit controls the second aliquoting probe based on the user's setting so that the second aliquoting probe aliqouts one of the first reagent and the second reagent. [5]

[0129] The automatic analysis device according to any one of [1] to [4] has a function of setting the threshold value for each measurement item. [6]

[0131] The automatic analysis device according to any one of [1] to [5] has a function of setting which one of the reagent and the diluent is dispensed using the second dispensing probe. [7]

[0133] The automatic analysis device according to any one of [1] to [6] has a function of setting which one of the first reagent and the second reagent is dispensed using the second dispensing probe. [8]

[0135] The automatic analysis device according to any one of [1] to [7] has a function of setting the threshold value in the setting screen for each measurement item. [9]

[0137] The automatic analysis device according to any one of [1] to [8] has a function of setting which one of the reagent and the diluent is dispensed using the second dispensing probe in the measurement order screen for each measurement item.

[10]

[0139] A method for transferring a mixed solution in an automatic analysis device, the automatic analysis device comprising:

[0140] A transfer mechanism for transferring a reaction tube for sample ejection and a reaction tube for transfer;

[0141] A first dispensing probe for dispensing a mixed solution containing a sample; and

[0142] A second dispensing probe for dispensing a reagent or a diluent,

[0143] The transfer method includes the following transfer steps:

[0144] When the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer exceeds the threshold value, the mixed solution is aspirated from the reaction tube for sample ejection in the first cycle, and the aspirated mixed solution is ejected into the reaction tube for transfer in the second cycle.

[11]

[0146] According to the method for transferring the mixed solution in the automatic analysis device described in

[10] , the following additional transfer steps are included: when the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer is equal to or less than the threshold value, the mixed solution is aspirated from the reaction tube for sample ejection in a single cycle, and the aspirated mixed solution is ejected into the reaction tube for transfer.

[12]

[0148] According to the method for transferring the mixed solution in the automatic analysis device described in

[10] or

[11] , before the transfer step, a determination step is included in which the control unit of the automatic analysis device determines whether the amount of the mixed solution to be transferred from the reaction tube for sample ejection to the reaction tube for transfer exceeds the threshold value.

[0149] In addition, the term "processor" in the above description means, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an Application Specific Integrated Circuit (ASIC), a programmable logic device (e.g., a Simple Programmable Logic Device (SPLD), a Complex Programmable Logic Device (CPLD), and a Field Programmable Gate Array (FPGA)), etc. When the processor is, for example, a CPU, the processor realizes each processing function by reading and executing a program stored in a storage circuit. On the other hand, when the processor is, for example, an ASIC, instead of storing the program in the storage circuit, the processing function is directly incorporated into the circuit of the processor as a logic circuit. In addition, each processor of the present embodiment is not limited to the case where each processor is configured as a single circuit, and multiple independent circuits may be combined to form one processor and realize its processing function. Furthermore, multiple constituent elements in Figure 1 may be integrated into one processor to realize its processing function.

[0150] Although several embodiments have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other ways, and various omissions, substitutions, changes, and combinations of the embodiments can be made without departing from the gist of the invention. These embodiments are included in the scope and gist of the invention, and are equally included in the scope of the invention described in the claims and its equivalents.

Claims

1. An automatic analysis device, wherein: have: A transfer mechanism for transferring the reaction tube for sample ejection and the reaction tube for transfer; A first dispensing probe is used to dispense a mixed liquid containing a sample; A second dispensing probe for dispensing reagents or diluents; and The control unit controls the first dispensing probe to cause the first dispensing probe to suck the mixed liquid from the sample ejecting reaction tube in a first cycle and eject the sucked mixed liquid to the transfer reaction tube in a second cycle when the amount of the mixed liquid to be transferred from the sample ejecting reaction tube to the transfer reaction tube exceeds a threshold value.

2. The automatic analysis device according to claim 1, wherein: When the amount of the mixed liquid to be transferred from the sample ejection reaction tube to the transfer reaction tube is below the threshold, the control unit controls the first dispensing probe so that the first dispensing probe sucks the mixed liquid from the sample ejection reaction tube in a single cycle and ejects the sucked mixed liquid into the transfer reaction tube.

3. The automatic analysis device according to claim 1, wherein: The control unit controls the second dispensing probe based on a setting by a user so that the second dispensing probe dispenses one of the reagent and the diluent.

4. The automatic analysis device according to claim 1, wherein: The control unit controls the second dispensing probe based on a setting by a user so that the second dispensing probe dispenses one of the first reagent and the second reagent.

5. The automatic analysis device according to claim 1, wherein: The function of setting the threshold value for each measurement item is provided.

6. The automatic analysis device according to claim 1, wherein: The device has a function of setting whether the second dispensing probe is used to dispense the reagent or the diluent.

7. The automatic analysis device according to claim 1, wherein: The device has a function of setting whether the first reagent or the second reagent is to be dispensed using the second dispensing probe.

8. The automatic analysis device according to claim 1, wherein: The function of setting the threshold value in the setting screen of each measurement item is provided.

9. The automatic analysis device according to claim 3, wherein: The device has a function of setting whether the reagent or the diluent is to be dispensed using the second dispensing probe on the measurement request screen for each measurement item.

10. A method for transferring a mixed solution in an automatic analysis device, wherein: The automatic analysis device comprises: A transfer mechanism for transferring the reaction tube for sample ejection and the reaction tube for transfer; a first dispensing probe for dispensing the mixed solution containing the sample; and The second dispensing probe is used to dispense reagents or diluents. The method for transferring the mixed solution in the automatic analysis device comprises the following transfer steps: When the amount of the mixed solution to be transferred from the sample ejection reaction tube to the transfer reaction tube exceeds a threshold value, the mixed solution is sucked from the sample ejection reaction tube in a first cycle, and the sucked mixed solution is ejected to the transfer reaction tube in a second cycle.

11. The method for transferring a mixed solution in an automatic analysis device according to claim 10, wherein: Other transfer processes are available as follows: When the amount of the mixed solution to be transferred from the sample ejection reaction tube to the transfer reaction tube is less than the threshold, the mixed solution is sucked from the sample ejection reaction tube and ejected to the transfer reaction tube in a single cycle.

12. The method for transferring a mixed solution in an automatic analysis device according to claim 10, wherein: Prior to the transfer step, a determination step is provided in which the control unit of the automatic analyzer determines whether the amount of the mixed solution to be transferred from the sample ejection reaction tube to the transfer reaction tube exceeds the threshold value.

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