An electronic air-oxygen mixer and a method for detecting carbon dioxide removal rate

Abstract

The embodiments of the present application provide an electronic air-oxygen mixer and a method for detecting carbon dioxide clearance, relating to the field of extracorporeal life support technology. The embodiments of the present application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time, enabling the electronic air-oxygen mixer to calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly based on carbon dioxide clearance rate data, promptly detecting functional decline or blockage of the membrane oxygenator, and avoiding carbon dioxide retention in the patient's body, thereby enhancing patient safety.

Description

Technical Field

[0001] The present application relates to the field of extracorporeal life support technology, and in particular to an electronic air-oxygen mixer and a method for detecting carbon dioxide clearance rate. Background Art

[0002] In extracorporeal life support technology, extracorporeal membrane oxygenation (ECMO) and extracorporeal CO2 removal (ECMO) are ) are two important treatment methods. These two treatment methods draw the patient's blood out of the body, oxygenate the blood and remove carbon dioxide through a membrane oxygenator, and then return the treated blood to the patient's body to maintain or assist the patient's life functions. In ECMO and During the treatment process, carbon dioxide clearance is an important indicator for evaluating the performance of membrane oxygenator.

[0003] Currently, the most common method for measuring CO2 clearance from membrane oxygenators is blood gas analysis. This method requires periodic collection of blood samples from the inlet and outlet ports of the membrane oxygenator. A blood gas analyzer is then used to measure key parameters in these blood samples (such as CO2 partial pressure, bicarbonate concentration, and total CO2). These parameters are then input into a CO2 solubility model to calculate CO2 clearance.

[0004] However, this method only periodically collects and analyzes blood samples and cannot perform real-time, continuous CO2 clearance monitoring. This is not only prone to errors caused by periodic sampling, reducing the accuracy and reliability of CO2 clearance data, but also hinders doctors from responding quickly to CO2 clearance data, limiting their ability to promptly detect membrane oxygenator dysfunction or blockage, which can lead to CO2 accumulation in patients and even worsen their condition. Summary of the Invention

[0005] Based on the above problems, the present application provides an electronic air-oxygen mixer and a method for detecting carbon dioxide removal rate, which can calculate and update the carbon dioxide removal rate in real time and continuously.

[0006] The embodiments of this application disclose the following technical solutions:

[0007] In a first aspect, the present application discloses an electronic air-oxygen mixer, comprising:

[0008] A mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor, and a main control module; wherein the mixing chamber is provided with an air inlet, an oxygen inlet, and a mixed gas outlet; the oxygen concentration flow sensor is provided on the gas flow path between the mixed gas outlet and the air inlet of the membrane oxygenator; the carbon dioxide gas concentration sensor is provided at the air outlet of the membrane oxygenator; the main control module is in communication with the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor;

[0009] The mixing chamber is used to mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet to obtain a mixed gas; and to input the mixed gas into the air inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor.

[0010] The oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time;

[0011] The carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration at the gas outlet of the membrane oxygenator in real time;

[0012] The main control module is configured to determine a carbon dioxide removal rate according to the volume flow of the mixed gas and the carbon dioxide concentration.

[0013] Optionally, the formula for determining the carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows:

[0014]

[0015] in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0016] Optionally, the electronic air-oxygen mixer further includes a first regulating valve and a second regulating valve; wherein the first regulating valve is connected to the air inlet, and is used to regulate the flow of medical compressed air entering the mixing chamber; the second regulating valve is connected to the oxygen inlet, and is used to regulate the flow of oxygen entering the mixing chamber;

[0017] The main control module is further configured to control the openings of the first regulating valve and the second regulating valve according to the carbon dioxide removal rate.

[0018] Optionally, the main control module is specifically configured to, when the carbon dioxide removal rate is lower than a first value, increase the opening of the second regulating valve, and / or decrease the opening of the first regulating valve;

[0019] When the carbon dioxide removal rate is higher than a second value, the opening of the first regulating valve is increased, and / or the opening of the second regulating valve is decreased, wherein the second value is higher than the first value.

[0020] Optionally, the main control module is further configured to trigger an alarm indication when the carbon dioxide clearance rate is higher than a third value, or when the carbon dioxide clearance rate is lower than a fourth value, wherein the third value is higher than the fourth value.

[0021] Optionally, the electronic air-oxygen mixer is used to communicate with a display module;

[0022] The main control module is further configured to send the carbon dioxide removal rate, the volume flow rate of the mixed gas, and the carbon dioxide concentration to the display module in real time, so that the display module displays at least one of the carbon dioxide removal rate, the volume flow rate of the mixed gas, and the carbon dioxide concentration.

[0023] Optionally, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation (ECMO) host or an extracorporeal carbon dioxide removal device. Host communication connection;

[0024] The main control module is also used to send real-time The host sends the carbon dioxide removal rate.

[0025] In a second aspect, the present application discloses a method for detecting carbon dioxide clearance rate, which is applied to the electronic air-oxygen mixer described in the first aspect, and the method comprises:

[0026] Obtaining the gas flow of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor;

[0027] A carbon dioxide removal rate is determined based on the volume flow rate of the mixed gas and the carbon dioxide concentration.

[0028] Optionally, the formula for determining the carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows:

[0029]

[0030] in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0031] Optionally, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation (ECMO) host or an extracorporeal carbon dioxide removal device. Host communication connection;

[0032] The method further comprises: providing real-time information to the ECMO host or the The host sends the carbon dioxide removal rate.

[0033] Compared with the existing technology, this application has the following beneficial effects:

[0034] An embodiment of the present application provides an electronic air-oxygen mixer and a method for detecting a carbon dioxide clearance rate. The electronic air-oxygen mixer includes a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor, and a main control module. The mixing chamber is provided with an air inlet, an oxygen inlet, and a mixed gas outlet. The oxygen concentration flow sensor is disposed in a gas flow path between the mixed gas outlet and the inlet of a membrane oxygenator. The carbon dioxide gas concentration sensor is disposed at the outlet of the membrane oxygenator. The main control module is communicatively connected to the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor. The mixing chamber is configured to mix medical compressed air input through the air inlet and oxygen input through the oxygen inlet to obtain a mixed gas. The mixed gas is input through the mixed gas outlet via the oxygen concentration flow sensor to the inlet of the membrane oxygenator. The oxygen concentration flow sensor is configured to monitor the volume flow of the mixed gas in real time. The carbon dioxide gas concentration sensor is configured to monitor the carbon dioxide concentration at the outlet of the membrane oxygenator in real time. The main control module is configured to determine a carbon dioxide clearance rate based on the volume flow and carbon dioxide concentration of the mixed gas. Thus, the embodiments of the present application utilize the oxygen concentration flow sensor and carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time, enabling the electronic air-oxygen mixer to continuously calculate and update the carbon dioxide clearance rate in real time. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables physicians to quickly respond based on carbon dioxide clearance rate data, promptly identifying any functional degradation or blockage of the membrane oxygenator, and preventing carbon dioxide retention in the patient's body, thereby enhancing patient safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0036] Figure 1 A schematic diagram of an electronic air-oxygen mixer provided in an embodiment of the present application;

[0037] Figure 2 A schematic diagram of another electronic air-oxygen mixer provided in an embodiment of the present application;

[0038] Figure 3 A schematic diagram of a data transmission system provided in an embodiment of the present application;

[0039] Figure 4 A flow chart of a method for detecting carbon dioxide removal rate provided in an embodiment of the present application;

[0040] Figure 5 A schematic diagram of a computer-readable medium provided in an embodiment of the present application. DETAILED DESCRIPTION

[0041] First, the technical terms involved in the embodiments of this application are explained:

[0042] Extracorporeal Membrane Oxygenation (ECMO) is an important extracorporeal life support technology, mainly used to provide continuous extracorporeal respiration and circulation for patients with severe cardiopulmonary failure. It draws the patient's blood out of the body, oxygenates it and removes carbon dioxide through a membrane oxygenator, and then returns the blood to the patient's body, thereby maintaining the patient's vital functions.

[0043] Extracorporeal CO2Removal ) is a treatment method that draws the patient's blood out of the body through an extracorporeal circulation device and removes carbon dioxide in the blood through a membrane oxygenator. It can effectively remove carbon dioxide generated by the body's metabolism to reduce the patient's ventilation needs and ventilator support level.

[0044] As previously described, the current method for measuring CO2 clearance from membrane oxygenators is typically blood gas analysis. This method requires periodic collection of blood samples from the inlet and outlet ports of the membrane oxygenator. A blood gas analyzer is then used to measure key parameters in these blood samples (such as partial pressure of carbon dioxide, bicarbonate concentration, and total carbon dioxide). These parameters are then input into a carbon dioxide solubility model to calculate CO2 clearance.

[0045] However, this method only periodically collects and analyzes blood samples and cannot perform real-time, continuous CO2 clearance monitoring. This is not only prone to errors caused by periodic sampling, reducing the accuracy and reliability of CO2 clearance data, but also hinders doctors from responding quickly to CO2 clearance data, limiting their ability to promptly detect membrane oxygenator dysfunction or blockage, which can lead to CO2 accumulation in patients and even worsen their condition.

[0046] After research, the inventors have proposed an electronic air-oxygen mixer and a method for detecting carbon dioxide clearance. The embodiments of this application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time. This allows the electronic air-oxygen mixer to continuously calculate and update the carbon dioxide clearance rate in real time. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables physicians to respond quickly based on carbon dioxide clearance rate data, promptly identifying any functional impairment or blockage of the membrane oxygenator, preventing carbon dioxide retention in the patient's body and thus enhancing patient safety.

[0047] In order to help those skilled in the art better understand the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of this application.

[0048] Example 1

[0049] See also Figure 1 , which is a schematic diagram of an electronic air-oxygen mixer provided in an embodiment of the present application. The electronic air-oxygen mixer includes a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor, and a main control module (not shown in the figure).

[0050] The mixing chamber is equipped with an air inlet, an oxygen inlet, and a mixed gas outlet. The air inlet and oxygen inlet are typically located at the top of the mixing chamber, while the mixed gas outlet is typically located on the side or bottom of the mixing chamber. The mixing chamber is used to thoroughly mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet to produce a mixed gas with a certain oxygen concentration. The mixed gas is then input into the membrane oxygenator's air inlet through the mixed gas outlet via an oxygen concentration flow sensor.

[0051] The oxygen concentration flow sensor is installed in the gas flow path between the mixed gas outlet and the membrane oxygenator's inlet. It monitors the volumetric flow rate of the mixed gas in real time. By accurately measuring the volumetric flow rate, the oxygen concentration flow sensor provides important data support for subsequent gas mixing control and monitoring.

[0052] The carbon dioxide gas concentration sensor is installed at the outlet of the membrane oxygenator. It monitors the carbon dioxide concentration of the oxygenated gas at the outlet in real time. Specifically, the carbon dioxide gas concentration sensor uses infrared absorption, utilizing the characteristic absorption peak of carbon dioxide molecules at 4.26μm in the infrared spectrum, to measure carbon dioxide concentration in real time.

[0053] The main control module is in communication with the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor. The main control module is used to determine the carbon dioxide removal rate based on the volume flow rate and carbon dioxide concentration of the mixed gas. Specifically, the carbon dioxide removal rate can be determined based on the volume flow rate and carbon dioxide concentration of the mixed gas using the following formula (1):

[0054] (1)

[0055] in, is the carbon dioxide clearance rate (mL / min), is the volume flow rate of the mixed gas (mL / min), is the carbon dioxide concentration (%).

[0056] It is understood that the overall workflow of the electronic air-oxygen mixer and membrane oxygenator is as follows: the oxygen inlet and air inlet of the electronic air-oxygen mixer are used to input oxygen and medical compressed air, respectively. After mixing, the oxygen and medical compressed air flow through the oxygen concentration flow sensor, and then are transported through the outlet of the electronic air-oxygen mixer to the membrane oxygenator's inlet, where they enter the membrane oxygenator's gas chamber. At this point, blood flows through the blood chamber on the other side of the membrane oxygenator's gas chamber, which is separated by an oxygenation membrane. Due to the semipermeability of the oxygenation membrane, oxygen diffuses from the gas side to the blood side, while carbon dioxide diffuses from the blood side to the gas side, thereby achieving blood oxygenation and carbon dioxide removal. The carbon dioxide gas that diffuses from the blood side to the gas side, along with the remaining mixed gas in the gas chamber, flows out of the membrane oxygenator's outlet. A carbon dioxide concentration sensor is located at the membrane oxygenator's outlet to measure the carbon dioxide in the mixed gas flowing out of the membrane oxygenator's outlet in real time. The carbon dioxide removal rate can be determined based on the volume flow rate and carbon dioxide concentration of the mixed gas.

[0057] In summary, this application discloses an electronic air-oxygen mixer. The embodiments of this application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time. This allows the electronic air-oxygen mixer to continuously calculate and update the carbon dioxide clearance rate in real time. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly based on the patient's carbon dioxide clearance rate data, promptly identifying any functional degradation or blockage of the membrane oxygenator, and preventing carbon dioxide retention in the patient's body, thereby enhancing patient safety.

[0058] Example 2

[0059] See also Figure 2 , which is a schematic diagram of another electronic air-oxygen mixer provided in an embodiment of the present application. Figure 2 The electronic air-oxygen mixer shown includes a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module, which are similar to those in the first embodiment and will not be described in detail here.

[0060] In a specific implementation, Figure 2 The electronic air-oxygen mixer shown also includes a first regulating valve and a second regulating valve. The first regulating valve is connected to the air inlet and is used to adjust the flow of medical compressed air entering the mixing chamber. The second regulating valve is connected to the oxygen inlet and is used to adjust the flow of oxygen entering the mixing chamber. It is understood that medical compressed air requires rigorous filtration and drying to ensure its purity and safety.

[0061] Then, the main control module is further used to dynamically adjust the openings of the first regulating valve and the second regulating valve according to the carbon dioxide removal rate to control the oxygen concentration and flow rate of the mixed gas.

[0062] Specifically, when the carbon dioxide clearance rate is low (for example, the carbon dioxide clearance rate is lower than the first value), this generally means that the patient may need a higher oxygen concentration to promote the excretion of carbon dioxide. In this case, the main control module will increase the opening of the second regulating valve to increase the oxygen flow rate, and / or reduce the opening of the first regulating valve to reduce the air flow rate, thereby reducing inactive gas components such as nitrogen in the mixed gas and indirectly increasing the oxygen concentration. When the carbon dioxide clearance rate is high (for example, the carbon dioxide clearance rate is higher than the second value), this means that the current oxygen concentration is too high and needs to be appropriately reduced to avoid the potential risk of oxygen poisoning. In this case, the main control module will reduce the opening of the second regulating valve to reduce the oxygen flow rate, and / or increase the opening of the first regulating valve to increase the air flow rate, thereby increasing nitrogen and other components in the mixed gas and indirectly reducing the oxygen concentration.

[0063] Through this dynamic adjustment mechanism, the electronic air-oxygen mixer automatically adjusts the ratio of oxygen to air in the mixed gas based on the patient's real-time respiratory status, ensuring the safety and effectiveness of treatment. This automated process not only reduces the need for manual intervention by medical staff, lowering operational difficulty and the risk of error, but also provides more precise and personalized treatment support to meet the specific needs of different patients.

[0064] In some specific implementations, the main control module is further configured to trigger an alarm indication to alert an operator or medical staff of a possible device operational anomaly when the carbon dioxide clearance rate exceeds a third value or falls below a fourth value (i.e., the carbon dioxide clearance rate exceeds a preset safety range). The third value is a preset maximum value, the fourth value is a preset minimum value, and the third value is higher than the fourth value.

[0065] Specifically, when the CO2 clearance rate exceeds the third value, it generally indicates that the oxygen concentration in the mixed gas may be too high, resulting in excessive CO2 removal. Excessive CO2 removal can lead to respiratory alkalosis, an acid-base imbalance caused by a decrease in blood bicarbonate concentration. To avoid this risk, the main control module triggers an alarm, alerting the operator or medical staff to immediately check and adjust the oxygen-air mixture to ensure that the oxygen concentration is within a safe range.

[0066] Conversely, when the CO2 clearance rate falls below the fourth value, this typically indicates low oxygen concentration in the mixed gas or insufficient gas flow, leading to inefficient CO2 removal. In this case, the patient may be at risk for respiratory acidosis, a condition characterized by excessively high blood bicarbonate concentrations, leading to an acid-base imbalance. To ensure patient safety, the main control module also triggers an alarm, alerting the operator or medical staff to take prompt action to increase the oxygen flow rate or adjust the mixing ratio to improve CO2 clearance and avoid acidosis.

[0067] Alarm indications are typically triggered through audible, visual, or other forms of alarm signals to ensure that operators or medical personnel are quickly aware of the current operating status of the device. These alarm signals may include, but are not limited to, audible, visual, and remote alarms.

[0068] The introduction of the alarm indication function not only improves the safety and reliability of electronic air-oxygen mixers but also enhances the operator's or medical staff's ability to monitor the device's operating status. By promptly responding to alarm indications, potential medical risks can be quickly identified and corrected, ensuring that patients receive safe and effective treatment. This also reduces the risk of medical accidents caused by equipment failure or operational errors, improving the overall quality of medical services.

[0069] In some specific implementations, the electronic air-oxygen mixer can be powered by a 12V DC power supply and connected to the display module via a communication protocol such as the Controller Area Network (CAN). The CAN bus is a multi-host serial communication bus with high communication speeds, strong anti-interference capabilities, and long transmission distances. In medical devices, the CAN bus is often used to connect various functional modules, enabling high-speed and reliable data transmission.

[0070] The main control module is further configured to transmit the CO2 clearance rate, the volumetric flow rate of the mixed gas, and the CO2 concentration to the display module in real time, so that the display module displays at least one of the CO2 clearance rate, the volumetric flow rate of the mixed gas, and the CO2 concentration via an intuitive interface. These interfaces may include digital displays or graphical interfaces. Users (e.g., patients, family members, and physicians) can view this data to understand treatment effectiveness and make more informed decisions.

[0071] In summary, this application discloses an electronic air-oxygen mixer. The embodiments of this application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time. This allows the electronic air-oxygen mixer to continuously calculate and update the carbon dioxide clearance rate in real time. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly based on the patient's carbon dioxide clearance rate data, promptly identifying any functional degradation or blockage of the membrane oxygenator, and preventing carbon dioxide retention in the patient's body, thereby enhancing patient safety.

[0072] Example 3

[0073] See also Figure 3 , which is a schematic diagram of a data transmission system provided by an embodiment of the present application. Figure 3 As shown, the data transmission system includes the electronic air-oxygen mixer disclosed in the above embodiment 1 or embodiment 2, and the ECMO host or Host. Among them, ECMO host or The host is used to support or replace the patient's lung function, especially in cases of severe respiratory failure or heart failure. They exchange gas through the membrane oxygenator, providing the patient with necessary oxygen and nutrients, while removing carbon dioxide and other wastes from the body. In addition, the electronic air-oxygen mixer communicates with the ECMO host or The host establishes a communication connection.

[0074] Then, the main control module is also used to send real-time The host sends the carbon dioxide clearance rate. By receiving carbon dioxide clearance data from the electronic air-oxygen mixer, the host can more accurately adjust treatment parameters such as gas flow and oxygen concentration. This precise adjustment helps optimize treatment outcomes, reduce complications, and improve patients' survival rates and quality of life.

[0075] In summary, the embodiment of the present application provides a data transmission system, which integrates an electronic air-oxygen mixer and an ECMO host or The system connects the host and enables data exchange through efficient communication protocols, significantly improving the accuracy and safety of treatment. This not only helps physicians more accurately assess patients' treatment progress and response, but also provides strong support for precise adjustment of treatment parameters. The application of this technical solution will help improve the effectiveness of extracorporeal membrane oxygenation or extracorporeal carbon dioxide removal therapy, bringing better treatment outcomes and quality of life to patients.

[0076] Example 4

[0077] See also Figure 4 , which is a flow chart of a method for detecting carbon dioxide removal rate provided in an embodiment of the present application. The method is applied to the electronic air-oxygen mixer disclosed in Example 1 or Example 2, and the method includes:

[0078] S401: Acquire the gas flow rate of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor.

[0079] S402: Determine a carbon dioxide removal rate based on the volume flow rate and carbon dioxide concentration of the mixed gas.

[0080] In some specific implementations, the carbon dioxide removal rate can be determined based on the volume flow rate and carbon dioxide concentration of the mixed gas using the following formula (2):

[0081] (2)

[0082] in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0083] In some specific implementations, the method further includes: triggering an alarm indication when the carbon dioxide clearance rate is higher than a third value, or when the carbon dioxide clearance rate is lower than a fourth value, wherein the third value is higher than the fourth value.

[0084] In some specific implementations, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation (ECMO) host or an extracorporeal carbon dioxide removal system. Host communication connection;

[0085] The method further comprises: providing real-time information to the ECMO host or The host sends the CO2 removal rate.

[0086] In summary, this application discloses a method for detecting carbon dioxide clearance rate. The embodiments of this application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into an electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of a membrane oxygenator in real time. This allows the electronic air-oxygen mixer to continuously calculate and update the carbon dioxide clearance rate in real time. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables physicians to quickly respond to patients' carbon dioxide clearance rate data, promptly identifying any functional impairment or blockage of the membrane oxygenator, and preventing carbon dioxide retention in the patient's body, thereby enhancing patient safety.

[0087] See also Figure 5 , which is a schematic diagram of a computer readable medium provided by an embodiment of the present application. The computer readable medium 500 stores a computer program 511, which implements the above-mentioned Figure 4 The steps of the method for detecting the carbon dioxide removal rate.

[0088] It should be noted that in the context of the present application, a machine-readable medium may be a tangible medium that may contain or store a program for use by an instruction execution system, device or equipment or used in conjunction with an instruction execution system, device or equipment. A machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or equipment, or any suitable combination of the foregoing. A more specific example of a machine-readable storage medium may include an electrical connection based on one or more lines, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0089] It should be noted that the machine-readable medium mentioned above in this application can be a computer-readable signal medium or a computer-readable storage medium, or any combination of the two. A computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or device, or any combination of the above. More specific examples of computer-readable storage media can include, but are not limited to: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above. In this application, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, device, or device. In this application, a computer-readable signal medium can include a data signal propagated in baseband or as part of a carrier wave, which carries computer-readable program code. This propagated data signal can take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. A computer-readable signal medium may also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport a program for use by or in conjunction with an instruction execution system, apparatus, or device. The program code contained on the computer-readable medium may be transmitted using any suitable medium, including but not limited to wires, optical cables, RF (radio frequency), etc., or any suitable combination thereof.

[0090] The computer-readable medium may be included in the electronic device, or may exist independently without being incorporated into the electronic device.

[0091] Although the subject matter has been described in language specific to structural features and / or methodological logical acts, it should be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or acts described above. Rather, the specific features and acts described above are merely example forms of implementing the claims.

[0092] Although several specific implementation details are included in the above discussion, these should not be construed as limiting the scope of this application. Certain features described in the context of separate embodiments may also be implemented in combination in a single embodiment. Conversely, various features described in the context of a single embodiment may also be implemented in multiple embodiments individually or in any suitable sub-combination.

[0093] The above description is merely a preferred embodiment of the present application and an illustration of the technical principles employed. Those skilled in the art should understand that the scope of disclosure in this application is not limited to the technical solutions formed by a specific combination of the above-mentioned technical features, but also encompasses other technical solutions formed by any combination of the above-mentioned technical features or their equivalents without departing from the above-mentioned disclosed concepts. For example, a technical solution formed by replacing the above-mentioned features with (but not limited to) technical features with similar functions disclosed in this application.

Claims

1. An electronic air-oxygen mixer, characterized in that: The electronic air-oxygen mixer comprises: a mixing chamber, an oxygen concentration flow sensor, a membrane oxygenator, a carbon dioxide gas concentration sensor, a main control module, a first regulating valve and a second regulating valve; The mixing chamber is provided with an air inlet, an oxygen inlet, and a mixed gas outlet; the oxygen concentration flow sensor is provided on the gas flow path between the mixed gas outlet and the air inlet of the membrane oxygenator; the carbon dioxide gas concentration sensor is provided at the air outlet of the membrane oxygenator; the main control module is communicatively connected to the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor; the first regulating valve is connected to the air inlet, and the first regulating valve is used to regulate the flow rate of medical compressed air entering the mixing chamber; the second regulating valve is connected to the oxygen inlet, and the second regulating valve is used to regulate the flow rate of oxygen entering the mixing chamber; The mixing chamber is used to mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet to obtain a mixed gas; and to input the mixed gas into the air inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor. The oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time; The membrane oxygenator is configured to allow oxygen in the mixed gas to diffuse from the gas side to the blood side and carbon dioxide in the mixed gas to diffuse from the blood side to the gas side based on the semipermeability of the oxygenation membrane of the membrane oxygenator; after mixing the carbon dioxide diffused from the blood side to the gas side with the remaining mixed gas, the secondary mixed gas is input into the gas outlet of the membrane oxygenator via the carbon dioxide gas concentration sensor; The carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration at the gas outlet of the membrane oxygenator in real time; The main control module is used to determine a carbon dioxide removal rate based on the product of the volume flow rate of the mixed gas and the carbon dioxide concentration; when the carbon dioxide removal rate is lower than a first value, increase the opening of the second regulating valve and / or reduce the opening of the first regulating valve; when the carbon dioxide removal rate is higher than a second value, increase the opening of the first regulating valve and / or reduce the opening of the second regulating valve, wherein the second value is higher than the first value.

2. The electronic air-oxygen mixer according to claim 1, characterized in that: The main control module is further configured to trigger an alarm indication when the carbon dioxide removal rate is higher than a third value or the carbon dioxide removal rate is lower than a fourth value, wherein the third value is higher than the fourth value.

3. The electronic air-oxygen mixer according to claim 1, characterized in that: The electronic air-oxygen mixer is used to communicate with the display module; The main control module is further configured to send the carbon dioxide removal rate, the volume flow rate of the mixed gas, and the carbon dioxide concentration to the display module in real time, so that the display module displays at least one of the carbon dioxide removal rate, the volume flow rate of the mixed gas, and the carbon dioxide concentration.

4. The electronic air-oxygen mixer according to any one of claims 1 to 3, characterized in that: The electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation ECMO host or an extracorporeal carbon dioxide removal ECCO2R host; The main control module is also used to send the carbon dioxide clearance rate to the ECMO host or the ECCO2R host in real time.

5. A method for detecting carbon dioxide removal rate, characterized in that: Applied to an electronic air-oxygen mixer according to any one of claims 1 to 4, the method comprises: Obtaining the gas flow of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor; determining a carbon dioxide removal rate according to a product of the volume flow rate of the mixed gas and the carbon dioxide concentration; When the carbon dioxide removal rate is lower than a first value, increasing the opening of the second regulating valve, and / or decreasing the opening of the first regulating valve; When the carbon dioxide removal rate is higher than a second value, the opening of the first regulating valve is increased, and / or the opening of the second regulating valve is decreased, wherein the second value is higher than the first value.

6. The method according to claim 5, characterized in that The formula for determining the carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows: ； in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

7. The method according to claim 5 or 6, characterized in that The electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation ECMO host or an extracorporeal carbon dioxide removal ECCO2R host; The method further includes: sending the carbon dioxide clearance rate to the ECMO host or the ECCO2R host in real time.

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