Composition for promoting longitudinal growth of bones, related product and application

Abstract

The invention provides a composition for promoting longitudinal growth of bones, a related product and application, and belongs to the technical field of bone health. The composition for promoting longitudinal growth of bones is prepared from the following components in parts by weight: 3-20 parts of hydrolyzed yolk powder, 2-15 parts of gamma-aminobutyric acid and 5-35 parts of yeast beta-glucan. The composition provided by the invention can effectively improve the nose-tail length and nose-anus length of rats, and improve the levels of osteocalcin (OC), alkaline phosphatase (ALP) and I-type procollagen carboxyl terminal peptide (PICP) of serum bone formation markers of the rats, has synergistic interaction, can be used for preparing food which is good in stability and good in taste and can promote longitudinal growth of bones, and has good application compatibility.

Description

Technical Field

[0001] The present invention belongs to the technical field of bone health and relates to a composition, related products and applications for promoting longitudinal bone growth. Background Art

[0002] Bone nutrition refers to the nutrients that make up bones, joints and teeth. The components of bone nutrition are very complex and include four categories. The first category is proteins, including multiple sub-categories such as collagen, glycoprotein, osteonectin, osteogenic protein, polypeptide, etc. Protein substances play an important role in the process of bone formation. They not only play a structural role in maintaining and bonding the inorganic structure of bones and improving bone toughness, but also play functional roles such as nourishing bone cells and reflecting enzyme activity. The second category is minerals. Calcium and phosphorus are the main bone-forming minerals. Other essential bone-forming minerals include magnesium, strontium, manganese, fluorine, etc. Calcium and phosphorus are the main inorganic components of bone tissue, and the content of calcium and phosphorus is closely related to bone density. The third category is lipids, including fats, phospholipids, cholesterol, etc., which are important components of bone marrow. The fourth category is polysaccharides, including chondroitin sulfate, hyaluronic acid and keratan sulfate protein, etc. Polysaccharides are important components of articular cartilage and synovial fluid, and a certain proportion of polysaccharides also exist in hard bones. The full absorption and utilization of bone nutrition are directly related to bone development and bone health, and are directly related to bone mass, bone density, etc.

[0003] Chinese invention patent CN114947138A provides a milk calcium composition for preventing and improving calcium deficiency diseases, its preparation and application. The raw material components include: milk mineral salts, concentrated whey protein, whole milk powder, colostrum, fructooligosaccharide, freeze-dried powder of Aronia melanocarpa, oat β-glucan, Pleurotus ostreatus powder, tart cherry powder. The milk calcium composition for preventing and improving calcium deficiency diseases described in this technology starts from supplementing easily absorbable calcium and improving multiple influencing factors including the human intestinal barrier, immune barrier, gastric acid secretion level, etc. that affect calcium absorption. Through the mutual cooperation and synergistic effect of each component, it can effectively prevent and improve various calcium deficiency symptoms in calcium-deficient populations.

[0004] Chinese invention patent CN112568294A provides a children's milk powder helpful for bone health and height development and its preparation method. The children's milk powder is prepared from components such as milk powder, demineralized whey powder, condensed milk powder, prebiotics, unsaturated fatty acids, hydrolyzed egg yolk powder, colostrum basic protein, lutein, vitamin K 2 , compound nutritional fortifiers, etc. The children's milk powder helpful for bone health and height development provided by this technology covers all-round nutrition required for children's growth and development, and is comprehensive and balanced. At the same time, on the basis of all-round nutrition, the children's milk powder helpful for bone health and height development in this technology assists in children's height development, forming a complete system for assisting bone development that organically combines supplementing calcium elements, promoting calcium absorption, and exerting the osteogenic effect of calcium, and the design is more scientific.

[0005] However, none of the above-mentioned prior arts can provide a composition for promoting longitudinal bone growth and related products with simpler components and better effects. Summary of the Invention

[0006] In view of this, aiming at the problems of the above-mentioned prior arts, the object of the present invention is to provide a composition, related products and applications for promoting longitudinal bone growth.

[0007] To achieve the above object of the invention, on the one hand, the present invention provides a composition for promoting longitudinal bone growth, which is composed of the following components by weight: 3-20 parts of hydrolyzed egg yolk powder, 2-15 parts of γ-aminobutyric acid, and 5-35 parts of yeast β-glucan.

[0008] Preferably, the composition is composed of the following components by weight: 8-12 parts of hydrolyzed egg yolk powder, 9-11 parts of γ-aminobutyric acid, and 6-8 parts of yeast β-glucan.

[0009] More preferably, the composition is composed of the following components by weight: 10 parts of hydrolyzed egg yolk powder, 10 parts of γ-aminobutyric acid, and 7 parts of yeast β-glucan.

[0010] On the other hand, the present invention provides a solid composition composed of the above composition and milk mineral salts, and the weight ratio of the composition to the milk mineral salts is 27:120-320.

[0011] Preferably, the weight ratio of the composition to the milk mineral salts is 27:220.

[0012] On the other hand, the present invention provides a solid composition composed of the above composition and mushroom powder, and the weight ratio of the composition to the mushroom powder is 27:1-5.

[0013] Preferably, the weight ratio of the composition to the mushroom powder is 27:3.

[0014] On the other hand, the present invention provides a solid composition composed of the above composition, mushroom powder and milk mineral salts, and the weight ratio of the composition, the mushroom powder and the milk mineral salts is 27:1-5:120-320.

[0015] Preferably, the weight ratio of the composition, the mushroom powder and the milk mineral salts is 27:3:220.

[0016] On the other hand, the present invention provides a product for promoting longitudinal bone growth, including the above composition or the above solid composition.

[0017] The product includes but is not limited to foods, medicines, etc.

[0018] The dosage forms of the product include, but are not limited to, those selected from liquid dosage forms, jelly dosage forms, gummy candies, chewable tablets, powders, tablets, solutions, granules, jelly, gummies, milkshakes, capsules, etc.

[0019] On the other hand, the present invention provides a food for promoting longitudinal bone growth, comprising the above composition or the above solid composition;

[0020] The dosage form of the food is selected from one of liquid, jelly, gummy candy, chewable tablet, powder, and capsule.

[0021] Preferably, the food further comprises one or more of food additives, fruit and vegetable juices, and fruit and vegetable powders.

[0022] As an example of the present invention, the food is composed of the following components by weight percentage:

[0023] Raw material 1%-20%, brown dextrin 0.1%-5%, chitosan oligosaccharide 0.1%-5% and the balance of water;

[0024] Wherein, the raw material is the above composition or the above solid composition.

[0025] Finally, the present invention provides the application of the above composition or the above solid composition in the production of products for promoting longitudinal bone growth.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The present invention provides a composition with a simple formula. By reasonably matching the proportions of three components, namely hydrolyzed egg yolk powder, γ-aminobutyric acid, and yeast β-glucan, it has the effect of significantly increasing the nose-to-tail length and nose-to-anus length of rats at 6 weeks and 9 weeks of age, and to a certain extent, improving the levels of serum bone formation markers osteocalcin (OC), alkaline phosphatase (ALP), and carboxy-terminal propeptide of type I procollagen (PICP) in 9-week-old rats, showing a synergistic effect. In addition, the composition of the present invention can be compounded with substances such as mushroom powder and milk mineral salts to prepare a food for promoting longitudinal bone growth with good stability and taste, and has good application compatibility. Detailed Embodiments

[0028] Terms and statements of the present invention:

[0029] 1. Articles "a", "an", and "the": Unless otherwise explicitly limited to one (kind) of object, it includes plural objects.

[0030] 2. Numerical Ranges: Unless otherwise explicitly indicated, all ranges or ratios disclosed herein will be understood to include any and all sub-ranges or sub-ratios contained therein. For example, a stated range or ratio of 1 to 30 should be considered to include any sub-range or sub-ratio, integer, decimal, or sub-range or sub-ratio consisting of integers or decimals between the minimum value of 1 and the maximum value of 30, including the endpoints.

[0031] The following non-limiting examples can enable those of ordinary skill in the art to more comprehensively understand the present invention, but do not limit the present invention in any way. The following content is merely an exemplary illustration of the scope claimed for the present invention. Those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, and such changes and modifications should also fall within the scope claimed for the present invention.

[0032] The present invention will be further described below by way of specific examples. All various chemical reagents used in the examples of the present invention are obtained through conventional commercial channels unless otherwise specified. Unless otherwise specified, the contents described below are mass contents. Unless otherwise specified, it is understood to be carried out at room temperature.

[0033] In the following examples, the sources of some reagents are as shown in Table 1 below:

[0034] Table 1

[0035] Name Manufacturer Hydrolyzed Egg Yolk Powder Hangzhou Kangyuan Food Technology Co., Ltd. γ-Aminobutyric Acid Bloomage Biotechnology Corporation Limited Yeast β-Glucan Angel Nutritech Co., Ltd. Milk Mineral Salt Arla Food Ingredients Group Mushroom Powder Linyi Youkang Biotechnology Co., Ltd. Chitosan Oligosaccharide Guangdong Mingcheng Biotechnology Co., Ltd. Brown Dextrin Shijiazhuang Tangtian Starch Co., Ltd.

[0036] Examples 1 - 5 provide a composition for promoting longitudinal bone growth, and the components are as shown in Table 2 below (unit: parts by weight).

[0037] Table 2

[0038] Group Hydrolyzed Egg Yolk Powder γ-Aminobutyric Acid Yeast β-Glucan Example 1 10 10 7 Example 2 8 11 8 Example 3 12 9 6 Example 4 3 2 35 Example 5 20 15 5

[0039] Examples 6 - 14 provide a solid-state composition, and the components are as shown in Table 3 below (unit: parts by weight).

[0040] Table 3

[0041] Group Hydrolyzed Egg Yolk Powder γ-Aminobutyric Acid Yeast β-Glucan Milk Mineral Salt Mushroom Powder Example 6 10 10 7 220 - Example 7 8 11 8 120 - Example 8 12 9 6 320 - Example 9 10 10 7 - 3 Example 10 8 11 8 - 1 Example 11 12 9 6 - 5 Example 12 10 10 7 220 3 Example 13 8 11 8 120 1 Example 14 12 9 6 320 5

[0042] Comparative Examples 1 - 5 provide a composition, and the components are as shown in Table 4 below (unit: parts by weight, "-" indicates that the component is not contained).

[0043] Table 4

[0044]

[0045]

[0046] Preparation Example 1

[0047] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0048] Mix hydrolyzed egg yolk powder, yeast β-glucan with an appropriate amount of water, and raise the temperature to 40-45 °C. After stirring and dissolving, add γ-aminobutyric acid, brown dextrin and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain the drink for promoting longitudinal bone growth.

[0049] The compositions provided in Examples 1-5 and Comparative Example 1 can be made into drinks according to the method of Preparation Example 1, and are respectively denoted as Drink Example 1-Drink Example 5 and Drink Comparative Example 1 in sequence.

[0050] Drink Comparative Example 6: Compared with Drink Example 1, the difference is that the dosage of brown dextrin is changed to 0.08% and the dosage of chitosan oligosaccharide is changed to 1%, and the rest are the same.

[0051] The formulas of Drink Example 1-Drink Example 5, Drink Comparative Example 1 and Drink Comparative Example 6 are shown in Table 5 below (weight percentage content).

[0052] Table 5

[0053] Group Hydrolyzed Egg Yolk Powder γ-Aminobutyric Acid Yeast β-Glucan Brown Dextrin Chitosan Oligosaccharide Water Beverage Example 1 2％ 2％ 1.4％ 0.54％ 0.54％ The balance Beverage Example 2 1.6％ 2.2％ 1.6％ 0.54％ 0.54％ The balance Beverage Example 3 2.4％ 1.8％ 1.2％ 0.54％ 0.54％ The balance Beverage Example 4 0.405％ 0.27％ 4.725％ 0.54％ 0.54％ The balance Beverage Example 5 2.7％ 2.025％ 0.675％ 0.54％ 0.54％ The balance Beverage Comparative Example 1 4.5％ 0.45％ 0.45％ 0.54％ 0.54％ The balance Beverage Comparative Example 6 2％ 2％ 1.4％ 0.08％ 1％ The balance

[0054] Preparation Example 2

[0055] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0056] Mix hydrolyzed egg yolk powder, yeast β-glucan with an appropriate amount of water, and raise the temperature to 40-45 °C. After stirring and dissolving, add γ-aminobutyric acid and auxiliary materials (one of chitosan oligosaccharide and brown dextrin), dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain the drink for promoting longitudinal bone growth. This method can prepare Drink Comparative Example 7 and Drink Comparative Example 8.

[0057] The formulas of Drink Comparative Example 7 and Drink Comparative Example 8 are shown in Table 6 below (weight percentage content).

[0058] Table 6

[0059] Group Hydrolyzed Egg Yolk Powder γ-Aminobutyric Acid Yeast β-Glucan Brown Dextrin Chitosan Oligosaccharide Water Beverage Comparative Example 7 2％ 2％ 1.4％ - 1.08％ The balance Beverage Comparative Example 8 1.6％ 2.2％ 1.6％ 1.08％ - The balance

[0060] Preparation Example 3

[0061] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0062] Mix hydrolyzed egg yolk powder, yeast β-glucan and milk mineral salts with an appropriate amount of water, and raise the temperature to 40-45 °C. After stirring and dissolving, add γ-aminobutyric acid, brown dextrin and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain the drink for promoting longitudinal bone growth.

[0063] The compositions provided in Examples 6 - 8 can be made into beverages according to the method of Preparation Example 3, and are respectively denoted as Beverage Example 6 - Beverage Example 8 in sequence.

[0064] The formulas of Beverage Example 6 - Beverage Example 8 are shown in Table 7 below (weight percentage content).

[0065] Table 7

[0066]

[0067] Preparation Example 4

[0068] Beverage for promoting longitudinal bone growth. The preparation method is as follows:

[0069] Mix hydrolyzed egg yolk powder, yeast β - glucan and mushroom powder with appropriate amount of water, and heat the temperature to 40 - 45°C. After stirring and dissolving, add γ - aminobutyric acid, brown dextrin and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain the beverage for promoting longitudinal bone growth.

[0070] The compositions provided in Examples 9 - 11 can be made into beverages according to the method of Preparation Example 4, and are respectively denoted as Beverage Example 9 - Beverage Example 11 in sequence.

[0071] The formulas of Beverage Example 9 - Beverage Example 11 are shown in Table 8 below (weight percentage content).

[0072] Table 8

[0073]

[0074] Preparation Example 5

[0075] Beverage for promoting longitudinal bone growth. The preparation method is as follows:

[0076] Mix hydrolyzed egg yolk powder, yeast β - glucan and mushroom powder with appropriate amount of water, and heat the temperature to 40 - 45°C. After stirring and dissolving, add γ - aminobutyric acid, brown dextrin and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain the beverage for promoting longitudinal bone growth.

[0077] The compositions provided in Examples 12 - 14 can be made into beverages according to the method of Preparation Example 5, and are respectively denoted as Beverage Example 12 - Beverage Example 14 in sequence.

[0078] The formulas of Beverage Example 12 - Beverage Example 14 are shown in Table 9 below (weight percentage content).

[0079] Table 9

[0080]

[0081] Preparation Example 6

[0082] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0083] Mix hydrolyzed egg yolk powder, yeast β-glucan with an appropriate amount of water, and raise the temperature to 40 - 45°C. After stirring and dissolving, add calcium aspartate, brown dextrin, and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain a drink for promoting longitudinal bone growth.

[0084] The composition provided in Comparative Example 2 was prepared according to the preparation method of Preparation Example 6, and the obtained drink was designated as Drink Comparative Example 2.

[0085] Preparation Example 7

[0086] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0087] Mix hydrolyzed egg yolk powder, yeast β-glucan with an appropriate amount of water, and raise the temperature to 40 - 45°C. After stirring and dissolving, add glutamic acid, brown dextrin, and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain a drink for promoting longitudinal bone growth.

[0088] The composition provided in Comparative Example 3 was prepared according to the preparation method of Preparation Example 7, and the obtained drink was designated as Drink Comparative Example 3.

[0089] Preparation Example 8

[0090] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0091] Mix hydrolyzed protein powder, soy lecithin powder, yeast β-glucan with an appropriate amount of water, and raise the temperature to 40 - 45°C. After stirring and dissolving, add brown dextrin and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain a drink for promoting longitudinal bone growth.

[0092] The composition provided in Comparative Example 4 was prepared according to the preparation method of Preparation Example 8, and the obtained drink was designated as Drink Comparative Example 4.

[0093] Drink Comparative Example 3

[0094] Preparation Example 9

[0095] A drink for promoting longitudinal bone growth. The preparation method is as follows:

[0096] Mix hydrolyzed protein powder, oat β-glucan with an appropriate amount of water, and raise the temperature to 40 - 45°C. After stirring and dissolving, add γ-aminobutyric acid, brown dextrin, and chitosan oligosaccharide, dissolve, make up the remaining amount of water, homogenize, and pasteurize to obtain a drink for promoting longitudinal bone growth.

[0097] The composition provided in Comparative Example 5 was prepared according to the preparation method of Preparation Example 9, and the obtained drink was denoted as Drink Comparative Example 5.

[0098] Effect Evaluation

[0099] Effect Example 1

[0100] Effect evaluation of the composition in promoting the longitudinal growth of rat bones.

[0101] Specific pathogen-free (SPF) male SD rats were selected and weaned at 21 days of age. After weighing the body weight at 23 days of age, they were randomly grouped and different treatments were carried out on rats in different groups. After 19 days of gavage treatment (at this time, the rats were 6 weeks old), the rats were anesthetized with ether, and in the ventral recumbent position, the nasotail length (the distance from the tip of the nose to the end of the tail) and nasoanal length (the distance from the tip of the nose to the anus) of the rats were measured. Each value of each rat was measured 3 times and the average value was taken. After the rats recovered from anesthesia, the gavage treatment was continued for 21 days. When the rats were 9 weeks old after 21 days, venous blood was taken from the orbital cavity, and the serum bone formation markers OC, ALP, and PICP were measured using a kit. After taking the blood, the rats were sacrificed, and the nasotail length and nasoanal length were measured again.

[0102] The gavage treatment methods for rats in different groups are as follows:

[0103] Blank control group: Normal diet, and gavaged with deionized water daily.

[0104] Example / Comparative Example group: Normal diet, and gavaged with the gavage solution formed by mixing the compositions of Examples 1 - 8 and Comparative Examples 1 - 5 with an appropriate amount of deionized water daily. The daily gavage dose was 0.84 g per kilogram of rat.

[0105] Milk mineral salt group: Normal diet, and gavaged with an aqueous solution of milk mineral salts, and the daily gavage dose was 0.84 g per kilogram of rat.

[0106] The compositions provided in Examples 1 - 8 and Comparative Examples 1 - 5 were mixed with an appropriate amount of quantified water to form a gavage solution.

[0107] The nasotail length and nasoanal length of rats in each group at 6 weeks and 9 weeks of age are shown in the following table (mean ± standard deviation, n = 7).

[0108] Table 10

[0109]

[0110]

[0111] Among them, in the data of the same column, aaa represents a significant difference compared with the blank control group and p < 0.001, aa represents a significant difference compared with the blank control group and p < 0.01, and a represents a significant difference compared with the blank control group and p < 0.05.

[0112] As can be seen from the data in Table 10, compared with the compositions provided in the comparative examples, the compositions provided in each of the examples have achieved an increase in the average lengths of the nose-tail length and nose-anus length of rats at 6 weeks and 9 weeks to varying degrees.

[0113] The levels of serum OC, ALP, and PICP in rats at 9 weeks of age in each group are shown in Table 11 below (mean ± standard deviation, n = 7).

[0114] Table 11

[0115] Group OC (ng / mL) ALP (U / L) PICP (pg / mL) Blank Control Group 0.48±0.09 78.10±13.43 39.06±7.64 Example 1 0.55±0.12 84.98±13.97 43.58±8.35 Example 2 0.54±0.11 84.88±13.57 43.14±8.54 Example 3 0.54±0.12 84.80±12.69 42.91±7.55 Example 4 0.53±0.14 83.76±14.75 42.62±7.68 Example 5 0.53±0.11 83.22±10.50 42.08±8.90 Example 6 0.66±0.10 88.30±11.92 46.42±6.27 Example 7 0.63±0.14 85.69±12.31 45.88±7.44 Example 8 0.64±0.13 85.24±12.90 45.84±6.75 Comparative Example 1 0.49±0.12 81.27±11.70 41.31±7.99 Comparative Example 2 0.50±0.12 80.61±13.60 40.35±6.76 Comparative Example 3 0.50±0.14 79.60±13.89 41.11±8.23 Comparative Example 4 0.48±0.17 81.95±12.12 40.14±8.77 Comparative Example 5 0.49±0.15 80.77±12.37 41.38±8.19 Milk Mineral Salt Group 0.52±0.13 82.07±12.14 42.90±8.69

[0116] As can be seen from the data in Table 11, compared with the blank control group, the compositions provided in each of the examples can increase the average level of OC in rat serum from 0.48 ng / mL to 0.53 - 0.66 ng / mL; the compositions provided in each of the examples can increase the average level of ALP in rat serum from 78.10 U / L to 83.22 - 88.30 U / L; the compositions provided in each of the examples can increase the average level of PICP in rat serum from 39.06 pg / mL to 42.08 - 46.42 pg / mL; while the compounds provided in each of the comparative examples cannot achieve this effect.

[0117] Effect Example 2

[0118] Evaluation of the taste of the drink: 20 volunteers were recruited to evaluate the taste of the drink. The specific process was as follows: 10 mL of the drink in each group was taken for drinking, and then its taste was immediately scored, and the sum of the taste score + texture score was recorded, and the average value was taken. After each group of drinks was scored, rinse the mouth thoroughly and then score the next group of drinks.

[0119] The evaluation criteria are shown in Table 12:

[0120] Table 12

[0121]

[0122] The scoring results are shown in Table 13 below.

[0123] Table 13

[0124]

[0125]

[0126] It can be seen that the beverage embodiment provided by the present invention has better taste and mouthfeel compared with each comparative example.

[0127] 2. Evaluation of beverage stability.

[0128] Referring to the "Requirements for the Stability Study of Formula Foods for Special Medical Purposes" (2017 Revised Edition), 10 mL of the beverages of each group of beverage embodiments and beverage comparative examples were taken and filled into transparent glass bottles. They were stored for 30 days, 60 days, and 90 days in an environment of 30°C ± 2°C and relative humidity of 60% ± 5% on the day of preparation and after preparation, and stored for 5 days and 10 days in an environment of 40°C to evaluate the stability of the beverages.

[0129] The evaluation criteria are shown in Table 14:

[0130] Table 14

[0131]

[0132] The scoring results are shown in Table 15 below.

[0133] Table 15

[0134]

[0135]

[0136]

[0137] It can be seen that the beverage provided by the present invention has good storage stability.

[0138] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than a limitation on the protection scope of the present invention. Any simple modification or equivalent replacement made by those of ordinary skill in the art to the technical solution of the present invention does not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for promoting longitudinal growth of bones, characterized in that: The invention comprises the following ingredients by weight: 3-20 parts of hydrolyzed egg yolk powder, 2-15 parts of gamma-aminobutyric acid and 5-35 parts of yeast beta-glucan.

2. The composition according to claim 1, characterized in that The invention comprises the following ingredients by weight: 8-12 parts of hydrolyzed egg yolk powder, 9-11 parts of gamma-aminobutyric acid and 6-8 parts of yeast beta-glucan.

3. The composition according to claim 2, characterized in that The invention comprises the following ingredients by weight: 10 parts of hydrolyzed egg yolk powder, 10 parts of gamma-aminobutyric acid and 7 parts of yeast beta-glucan.

4. A solid composition consisting of the composition according to any one of claims 1 to 3 and milk mineral salts, characterized in that: The weight ratio of the composition to the milk mineral salt is 27:120-320.

5. A solid composition consisting of the composition according to any one of claims 1 to 3 and mushroom powder, characterized in that: The weight ratio of the composition to the mushroom powder is 27:1-5.

6. A solid composition consisting of the composition according to any one of claims 1 to 3, mushroom powder and milk mineral salt, characterized in that: The weight ratio of the composition, the mushroom powder and the milk mineral salt is 27:1-5:120-320.

7. A product for promoting longitudinal growth of bones, characterized in that: The invention comprises the composition according to any one of claims 1 to 3 or the solid composition according to any one of claims 4 to 6.

8. A food for promoting longitudinal growth of bones, characterized in that: A composition comprising any one of claims 1 to 3 or a solid composition according to any one of claims 4 to 6; The dosage form of the food is selected from one of liquid, jelly, gel candy, tablet candy, powder and capsule.

9. The food according to claim 8, characterized in that It also includes one or more of food additives, fruit and vegetable juices, and fruit and vegetable powders.

10. Use of the composition according to any one of claims 1 to 3 or the solid composition according to any one of claims 4 to 6 in the production of a product for promoting longitudinal bone growth.

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