Inhalation simulation device and medicine powder measuring system

Abstract

The invention discloses a simulation inhalation device and a medicine powder measuring system. The inhalation simulation device is used for being matched with a medicine powder measuring rod to distribute medicine powder, and comprises a main body part, a gas inlet, a gas outlet, a gas inlet, a gas outlet, a gas outlet, a gas inlet and a gas outlet, the gas inlet and the gas outlet are arranged on the main body part; the accommodating cavity is configured on the main body part to receive the medicine powder measuring rod and is communicated with the cavity inlet, so that the dosage groove of the medicine powder measuring rod is communicated with the cavity inlet when the medicine powder measuring rod is butted with the accommodating cavity; the gas flow can carry medicine powder in the dosage groove to the cavity outlet from the cavity inlet.

Description

Technical Field

[0001] This application relates to the technical field of airflow analysis and testing of pharmaceutical powders, and particularly to an inhalation simulation device and a powder measurement system. Background Art

[0002] The airflow analysis and testing of powders can evaluate the inhalation performance of drugs. Conducting airflow analysis and testing on devices such as airflow-based drug dispensing devices (e.g., inhalers) can evaluate the performance of the devices and the delivery and deposition of drugs in the respiratory system to ensure that patients can effectively inhale drug particles when using these devices.

[0003] However, in the airflow analysis and testing of inhalers and other airflow-based dispensing devices, on the one hand, it is necessary to ensure that the amount of powder is a certain dose, and on the other hand, it is necessary to form an airflow. This results in only being able to use the inhaler itself for sampling and consumptive testing. This method requires the completion of all development of the inhaler, and the consumptive testing causes waste of resources. Even many manufacturers do not conduct tests or conduct individual tests before leaving the factory, which is likely to lead to unsatisfactory treatment effects for users.

[0004] Therefore, how to simulate the testing of such airflow dispensing devices without using the device itself is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0005] In view of the above-mentioned disadvantages of the related art, the purpose of this application is to provide an inhalation simulation device and a powder measurement system to overcome the technical problem of only being able to conduct consumptive testing when performing airflow analysis and testing on airflow-based drug dispensing devices in the above-mentioned related art.

[0006] To achieve the above purpose and other related purposes, the first aspect of this application provides an inhalation simulation device for powder dispensing in cooperation with a powder measurement rod. The inhalation simulation device includes: a main body portion, on which a manifold is configured, the manifold having a chamber inlet and a chamber outlet; a receiving chamber configured on the main body portion to receive the powder measurement rod, which is connected to the chamber inlet so that when the powder measurement rod docks with the receiving chamber, the dose slot of the powder measurement rod communicates with the chamber inlet, enabling airflow to carry the powder in the dose slot from the chamber inlet to the chamber outlet.

[0007] The second aspect of the present application provides a powder measuring system, including: a powder measuring rod for accommodating a preset amount of powder; a simulated inhalation device for docking with the powder measuring rod to perform powder distribution, which is configured as the simulated inhalation device described in any one of the embodiments disclosed in the first aspect of the present application; a testing device for corresponding to the chamber outlet of the simulated inhalation device to complete a testing operation; and an access device for configuring the simulated inhalation device to transfer the simulated inhalation device to correspond to the testing device.

[0008] The third aspect of the present application provides a powder measuring system, including: a powder measuring rod for accommodating a preset amount of powder; a powder filling device for receiving the powder measuring rod to fill powder into the powder measuring rod; a transfer device for receiving the powder measuring rod containing powder to store or transfer the powder measuring rod; and a simulated inhalation device for docking with the powder measuring rod to perform powder distribution, which is configured as the simulated inhalation device described in any one of the embodiments disclosed in the first aspect of the present application.

[0009] In summary, for the simulated inhalation device and the powder measuring system provided by the present application, by providing a powder measuring rod, the accommodation of a preset amount of powder is realized, thereby realizing the accuracy of the test dose; by providing a powder filling device, the filling of the preset amount of powder in the powder measuring rod is realized, thereby further realizing the accuracy of the test; by providing a transfer device, the storage and transfer of the powder measuring rod are realized, which can avoid the loss and contamination of the powder; by providing a simulated inhalation device, the formation of air flow can be realized, and docking with the powder measuring rod can be completed to perform drug distribution; through the coordinated action of the powder measuring rod, the powder filling device, the transfer device and the simulated inhalation device, the air flow analysis test of air flow type dispensing devices such as inhalers can be realized, thereby avoiding the consumptive test of using the inhaler itself. Description of the Drawings

[0010] The specific features involved in the present application are shown in the appended claims. The features and advantages of the invention involved in the present application can be better understood by referring to the exemplary embodiments and the drawings described in detail below. A brief description of the drawings is as follows:

[0011] Figure 1 It shows a schematic structural diagram of the powder measuring rod in an embodiment of the present application.

[0012] Figure 2 It shows a schematic structural diagram of the powder measuring rod with an identification structure configured thereon in an embodiment of the present application.

[0013] Figure 3 It shows a schematic diagram of the proximal end face of the powder measuring rod in an embodiment of the present application.

[0014] Figure 4 It shows a schematic diagram of the proximal end face of the powder measuring rod in one embodiment of the present application.

[0015] Figure 5 It shows a schematic diagram of the powder measuring rod assembly in one embodiment of the present application.

[0016] Figure 6 It shows a schematic diagram of the proximal end face of the powder measuring rod assembly in one embodiment of the present application.

[0017] Figure 7 It shows a schematic structural diagram of the powder filling device in one embodiment of the present application from one perspective.

[0018] Figure 8 It shows a schematic structural diagram of the powder filling device in one embodiment of the present application from another perspective.

[0019] Figure 9 It shows a schematic structural diagram of the configurable tray of the powder filling device in one embodiment of the present application.

[0020] Figure 10 It shows a schematic diagram of the powder filling assembly in one embodiment of the present application.

[0021] Figure 11 It shows a schematic structural diagram of the transfer device in one embodiment of the present application.

[0022] Figure 12 It shows a schematic exploded view of the transfer device in one embodiment of the present application.

[0023] Figure 13 It shows a schematic diagram of the process of the frame moving relative to the base to lock the powder measuring rod in one embodiment of the present application.

[0024] Figure 14 It shows a schematic structural diagram of the simulated inhalation device in one embodiment of the present application.

[0025] Figure 15 It shows a schematic cross-sectional view of the manifold disposed in the main body portion in one embodiment of the present application.

[0026] Figure 16 It shows a schematic diagram of the release of the fixing mechanism and the positioning plate of the simulated inhalation device in one embodiment of the present application.

[0027] Figure 17 It shows a schematic diagram of the engagement of the fixing mechanism and the positioning plate of the simulated inhalation device in one embodiment of the present application.

[0028] Figure 18 It shows a cross-sectional view of the simulated inhalation device without the manifold installed in one embodiment of the present application.

[0029] Figure 19 It shows a schematic structural view of the simulated inhalation device in another perspective in an embodiment of the present application.

[0030] Figure 20 It shows a sectional view of the simulated inhalation device in an embodiment of the present application.

[0031] Figure 21 It shows a schematic process view of the docking of the simulated inhalation device and the powder measuring rod in an embodiment of the present application. Detailed implementation manners

[0032] The following specific embodiments illustrate the implementation manners of the present application. Those skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in this specification.

[0033] In the following description, reference is made to the accompanying drawings, which describe several embodiments of the present application. It should be understood that other embodiments may also be used, and mechanical composition, structure, electrical, and operational changes may be made without departing from the spirit and scope of the present disclosure. The following detailed description should not be considered restrictive, and the scope of the embodiments of the present application is only defined by the claims of the published patent. The terms used herein are only for describing specific embodiments and are not intended to limit the present application. Spatially related terms, such as "upper", "lower", "left", "right", "below", "beneath", "lower part", "above", "upper part", etc., may be used in the text to facilitate the description of the relationship between one element or feature shown in the figure and another element or feature.

[0034] Although in some instances the terms first, second, etc. are used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, the first powder measuring rod may be referred to as the second powder measuring rod, and similarly, the second powder measuring rod may be referred to as the first powder measuring rod, without departing from the scope of the various described embodiments. The first powder measuring rod and the second powder measuring rod are both describing a certain powder measuring rod, but unless the context clearly indicates otherwise, they are not the same powder measuring rod. Similar situations also include the first recess and the second recess, the first powder and the second powder, etc.

[0035] Furthermore, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly dictates otherwise. It should be further understood that the terms "comprising", "including" indicate the presence of the stated features, steps, operations, elements, components, items, kinds, and / or groups, but do not preclude the presence, occurrence or addition of one or more other features, steps, operations, elements, components, items, kinds, and / or groups. The terms "or" and "and / or" as used herein are to be construed as inclusive, or meaning any one or any combination. Thus, "A, B or C" or "A, B and / or C" means "any of the following: A; B; C; A and B; A and C; B and C; A, B and C". An exception to this definition occurs only when the combination of elements, functions, steps or operations are inherently mutually exclusive in some manner.

[0036] In view of the technical problems mentioned in the background art, the present application discloses a powder measuring rod, a powder measuring rod assembly, a powder filling device, a powder filling assembly, a transfer device, a transfer assembly, a simulated inhalation device and a powder measuring system. By providing the powder measuring rod, the accommodation of a preset amount of powder is achieved, thereby realizing the accuracy of the test dose. By providing the powder filling device, the filling of the preset amount of powder in the powder measuring rod is realized, thereby further realizing the accuracy of the test. By providing the transfer device, the storage and transfer of the powder measuring rod are realized, and the loss and contamination of the powder can be avoided. By providing the simulated inhalation device, the formation of an air flow can be realized, and docking with the powder measuring rod can be completed for drug dispensing. Through the synergistic effect of the powder measuring rod, the powder filling device, the transfer device and the simulated inhalation device, the air flow analysis test of an inhaler-type air flow dispensing device can be realized, thereby avoiding the consumptive test of using the inhaler itself.

[0037] To clearly illustrate the positional relationship of each component, structure, assembly, mechanism, device, or apparatus, etc. in the embodiments of the present application, in the general usage state, the side close to the operator is defined as the proximal end (which may also be referred to as the near side, front side, or front end, etc.), the side far from the operator is defined as the distal end (which may also be referred to as the far side, rear side, or rear end, etc.), the side located on the right side of the operator is defined as the right side (which may also be referred to as the right, right side, etc.), and the side located on the left side of the operator is defined as the left side (which may also be referred to as the left, left side, etc.). The side close to the operation platform (which may also be referred to as the support surface, operation surface, etc.) is defined as the lower side or the bottom, the side far from the operation platform is defined as the upper side or the top, and the plane where the operation platform is located is defined as the horizontal plane (which may also be referred to as the horizontal direction), and the plane perpendicular to the horizontal plane is defined as the vertical plane (which may also be referred to as the vertical plane, vertical direction, or perpendicular direction). It should be understood that the orientations defined here do not represent absolute positions, but relative positions.

[0038] The operator refers to a person or machine that operates various components, structures, assemblies, mechanisms, equipment, or devices. Among them, the person can be, for example, a professional responsible for performing analytical tests, collecting data, or ensuring the accuracy and smoothness of the test process. For example, it can be a test engineer, a laboratory technician, or a data collector, etc. The machine can, for example, include a robotic arm. In the following embodiments, an operator is taken as an example for illustration, which should not be construed as a limitation to this application.

[0039] The operation platform refers to a platform or workbench for placing or supporting these components, structures, assemblies, mechanisms, equipment, or devices, which can be, for example, a table, a laboratory bench, a weighing table, etc.

[0040] In some embodiments, this application discloses a powder measuring system, which includes a powder measuring rod, a powder filling device, a transfer device, and a simulated inhalation device. It should be noted here that the number and type of the powder measuring rod, powder filling device, transfer device, and simulated inhalation device included in the powder measuring system disclosed in this application are not limited. For example, in some embodiments, the powder measuring system may also include a powder measuring rod assembly, a powder filling assembly, a transfer assembly, and a simulated inhalation device. Among them, the powder measuring rod assembly includes at least two powder measuring rods, the powder filling assembly includes at least two powder filling devices, and the transfer assembly includes at least two transfer devices.

[0041] The following combines Figures 1 to 21 the shown embodiments to respectively illustrate the powder measuring rod and rod assembly, powder filling device and filling assembly, transfer device and transfer assembly, and simulated inhalation device disclosed in this application.

[0042] This application discloses a powder measuring rod in some embodiments. The powder measuring rod is used to hold a preset amount of powder. Please refer to Figure 1 , which shows a schematic structural diagram of the powder measuring rod in an embodiment of this application. As Figure 1 shown, the powder measuring rod 1 includes a rod 11 and a dose slot 12. The rod 11 further includes a rod body 110, an operation section 111, and a measuring section 112. The operation section 111 is located at the proximal end of the rod body 110, and the measuring section 112 is located at the distal end of the rod body 110. The dose slot 12 is provided on the circumferential surface of the measuring section 112 for holding a preset amount of powder. When the rod 11 is transferred to be docked with the simulated inhalation device through the operation section 111, the dose slot communicates with the chamber inlet of the simulated inhalation device so that the airflow carries the powder in the dose slot from the chamber inlet to the chamber outlet of the simulated inhalation device to complete the test operation. Among them, the structure of the simulated inhalation device will be described in detail later.

[0043] Figure 1The shape of the rod 11 shown is only a schematic representation. In an embodiment, the rod includes, but is not limited to, a straight rod and a curved rod, and its cross-section includes, but is not limited to, a circular shape, a quasi-circular shape, a polygon, and a quasi-polygon, as long as it can adapt to devices or equipment such as its insertion or docking, etc.

[0044] Among them, the operation section provides an operation space for the operator. The operator can operate the powder measuring rod by holding the operation section. For example, operations such as transfer, placement, insertion, rotation, docking, etc. that require contact with the powder measuring rod. In one embodiment, the operation section can be configured as a handle provided at the proximal end of the rod body, and the operator operates the handle to act on the powder measuring rod. In one embodiment, as Figure 1 shown, the operation section 111 is configured to be formed by the rod body extending along the proximal end. The operator can hold this part to operate the powder measuring rod 1. For example, the operator's fingers can hold this part to operate the powder measuring rod 1.

[0045] In one embodiment, as Figure 1 shown, a holding portion 113 is provided on the operation section 111 for holding the rod 11. That is, the operator can operate the powder measuring rod 1 by holding the holding portion 113. Further, the holding portion 113 can be configured as a concave structure formed on the circumferential surface of the operation section 111. The concave structure provides a holding space, and the operator's fingers can be located in the concave structure. In one example, the concave structure is configured as a concave portion formed by recessing downward on the circumferential surface of the operation section, and the operator's fingers can be placed in this concave portion for easy operation. In another example, the concave structure can also include a first concave portion and a second concave portion. The first concave portion and the second concave portion are distributed relatively on the circumferential surface of the operation section for holding. For example, the operator's thumb can be placed in the first concave portion, and the index finger or middle finger can be placed in the second concave portion to facilitate grasping the powder measuring rod and transferring it. For example, the first concave portion and the second concave portion can be distributed relatively left and right on the circumferential surface of the operation section, or can be distributed relatively up and down on the circumferential surface of the operation section. It should be understood that the holding portion 113 can be provided at any position of the operation section 111 as long as the operator's grasping can be achieved. Of course, the holding portion 113 can also not be provided, and the operator can directly grasp on the operation section.

[0046] In one embodiment, please continue to refer to Figure 1 , the measuring section 112 can be configured to be formed by the rod body 110 extending along the distal end, and the dose groove 12 can be configured as a groove formed by the measuring section 112 recessing downward. Of course, in other embodiments, the measuring section can also be configured as a component connected to the distal end of the rod body, and the dose groove is a part of the measuring section.

[0047] As described above, the dose slot 12 is used to accommodate a preset amount of powder. The powder may be, for example, a single-component drug powder or a mixed drug powder used to treat asthma and other respiratory inflammatory diseases, such as atropine, budesonide, and salmeterol, etc., or any combination thereof. The preset amount refers to the single-dose amount that can produce a therapeutic effect of the drug or the single-dose amount of a certain component that produces a therapeutic effect in the mixed powder. In one embodiment, the preset amount can be configured to any value not greater than 30 μl, such as 5 μl, 8 μl, 10 μl, 15 μl, 18 μl, 20 μl, 25 μl, 30 μl, etc. Preferably, the preset amount is configured to be 5 μl to 20 μl. It should be understood that according to the accommodation volume of the dose slot corresponding to the preset amount and the shape of the dose slot, the size that the dose slot should be set can be obtained.

[0048] In one embodiment, as Figure 1 shown, the dose slot 12 is configured to have a nearly elliptical opening. In some other embodiments, the dose slot can be configured with a circular opening, a square opening, or a V-shaped opening, but not limited thereto, and is specifically selected according to actual needs and the manufacturer's design.

[0049] To facilitate the powder to fall to the bottom of the dose slot, in one embodiment, the dose slot 12 is configured as a slot structure with a continuously decreasing cross-section from top to bottom, such as a funnel shape. This structure can, on the one hand, facilitate the filling of the powder into the dose slot, and on the other hand, is more similar to the structure of the medicine capsule in the inhaler, enabling the airflow to carry the powder distribution in a way closer to the real device during the analysis and testing process, thereby improving the accuracy of the test. Of course, the slot structure can also be set to other shapes, as long as it has the accommodation volume corresponding to the preset amount of the powder and can be adapted to the simulated inhalation device.

[0050] Please refer to Figure 2 , which shows a schematic structural diagram of the powder measuring rod with an identification structure configured thereon in one embodiment of the present application. As shown in the figure, an identification structure 115 is configured on the rod 11 to provide an indication to the operator. In one example, the identification structure can be used to indicate the type of the powder measuring rod. The type of the powder measuring rod refers to different powder measuring rods. For example, the identification structure can distinguish the types of powders accommodated in the dose slot. In one example, the identification structure can be used to indicate the state of the powder measuring rod. The state of the powder measuring rod refers to the current situation where the powder measuring rod is used by the operator to perform an operation, such as the placement state and the docking state. It should be understood that the placement state refers to the state when the powder measuring rod is placed on a horizontal plane. At this time, the opening of the dose slot faces upward, and the identification structure is in an inclined direction. The docking state refers to the state when the powder measuring rod is used to complete the docking with the simulated inhalation device. In one example, the identification structure can both indicate the type of the powder measuring rod and the state of the powder measuring rod.

[0051] The identification structure includes, but is not limited to, visual identifications such as color identification, number identification, letter identification, or any combination of the above identifications. The ways of configuring the identification structure on the rod include, but are not limited to, pasting, engraving, labeling, laser engraving, and digital display screens. Further, for the convenience of the operator to observe, the identification structure can be configured on the end face of the proximal end of the rod.

[0052] In an embodiment where the identification structure is configured as a letter identification, the letter corresponding to the letter identification can be used to indicate the type of the powder measuring rod. When the types of powders used for analysis tests are different or when it is necessary to mix the powders in different powder measuring rods during the analysis test, the letter can conveniently give a visual indication to the operator. The operator can judge which powder is contained in the powder measuring rod by observing the letter to avoid confusion. For example, as Figure 2 shown, the letter A can be marked on the end face of the rod 11 of the powder measuring rod 1 to indicate that the first powder with a preset amount is contained in its dose slot 12, and the letter B can be marked on the end face of another powder measuring rod to indicate that the second powder with a preset amount is contained in its dose slot. Thus, the operator can distinguish the two powder measuring rods by the letters A and B.

[0053] In an embodiment where the identification structure is configured as a letter identification, the pose of the letter corresponding to the letter identification can be used to indicate the state of the powder measuring rod. When the powder measuring rod is placed on a horizontal plane, the letter identification forms a preset angle with the vertical direction; when the powder measuring rod is in a docking state, the letter identification rotates from a preset angle with the vertical direction to an upright position to indicate correct docking. The rotation of the letter identification in the docking state will be described in detail later.

[0054] Please refer to Figure 3 , which shows a schematic diagram of the proximal end face of the powder measuring rod in an embodiment of the present application. For the convenience of description, the dose slot that is not visible from the perspective of the proximal end face is shown in a dashed line in the figure. As shown in the figure, the identification structure 115 is configured to have a preset angle with respect to the vertical direction of the dose slot 12. The preset angle refers to the angle α between the direction where the letter corresponding to the letter identification is located and the vertical direction of the dose slot 12. Among them, the preset angle can be a positive angle value or a negative angle value. The positive angle value represents a clockwise rotation starting from the vertical direction of the dose slot 12 (forming the preset angle α marked as in Figure 3 ), and the negative angle value represents a counterclockwise rotation starting from the vertical direction of the dose slot 12. As Figure 3In the illustrated embodiment, the preset included angle α is configured to be 45°, indicating that the letter A rotates 45° clockwise starting from the vertical direction of the dose slot 12. Of course, the preset included angle α can also be configured to be -45°, indicating that the letter A rotates 45° counterclockwise starting from the vertical direction of the dose slot 12. It should be understood that the above 45° or -45° is only an example, and those skilled in the art can also configure it to other angles under the inspiration of this application, such as 30°, -30°, 60°, -60°, etc.

[0055] In one embodiment, the rod of the powder measuring rod has a preset length, and the preset length is used to indicate the type of the powder measuring rod. The preset length refers to the length of the powder measuring rod set in advance. When the types of powders used for analysis and testing are different or when it is necessary to mix the powders in different powder measuring rods during analysis and testing, the preset length can conveniently give a visual indication to the operator. The operator can judge which powder is contained in the powder measuring rod by observing the length of the powder measuring rod, so as to avoid confusion. For example, a relatively short preset length of the rod of the powder measuring rod can indicate that a preset amount of the first powder is contained in its dose slot, and a relatively long preset length of the rod can indicate that a preset amount of the second powder is contained in its dose slot. Thus, the operator can distinguish the two powder measuring rods through the preset length of the rod.

[0056] In another embodiment, different preset lengths also play a role in facilitating the operation of the operator when the powder measuring rod is docked with the simulated inhalation device, and this role will be described in detail later.

[0057] It should be noted here that the method for the powder measuring rod to indicate the type can be one of setting different letter identifications and different preset lengths, or these two methods can be used simultaneously to minimize the possibility of confusion for the operator. Of course, the method for indicating the type of the powder measuring rod can also be changed in other ways, such as setting the rod or the end face to different colors, as long as the types of powders in the powder measuring rod can be distinguished, they all belong to the content protected by this application.

[0058] As Figure 1 shown, the powder measuring rod 1 further includes a positioning portion 114 disposed on the bottom side of the rod 11. The positioning portion 114 is used to support the rod 11 so that when the rod 11 is placed on a horizontal plane, the opening of the dose slot 12 faces upward, and at the same time, the powder measuring rod 1 is placed more stably on the operating table, avoiding its flipping and tipping. Please refer to Figure 4 and combine with Figure 1 , in which, Figure 4Shown is a schematic diagram of the proximal end face of the powder measuring rod in an embodiment of the present application. For ease of illustration, the dose slots that are not visible from the perspective of the proximal end face are shown in dashed lines in the figure. As shown in the figure, the positioning portion 114 is configured to have a preset angle with respect to the vertical direction of the dose slot 12. The preset angle refers to the included angle β between the axis direction of the positioning portion 114 and the vertical direction of the dose slot 12. Among them, the preset angle can be divided into a positive angle value and a negative angle value. The positive angle value represents a clockwise rotation starting from the vertical direction of the dose slot 12, and the negative angle value represents a counterclockwise rotation starting from the vertical direction of the dose slot 12. As Figure 4 shown, the preset angle β is configured to be -60°, indicating a counterclockwise rotation of 60° of the axis direction of the positioning portion 114 starting from the vertical direction of the dose slot 12. Of course, the preset angle β can also be configured to be 60°, indicating a clockwise rotation of 60° of the axis direction of the positioning portion 114 starting from the vertical direction of the dose slot 12.

[0059] In an embodiment, as Figures 1 to 4 shown, the positioning portion 114 is configured as a cylindrical structure protruding in the circumferential direction of the rod 11. The cylindrical structure can be configured to be integrally formed with the rod 11. When the powder measuring rod is placed on a horizontal plane, the cylindrical structure provides a point support for the rod 11. In another embodiment, the positioning portion can be configured as a convex point structure protruding in the circumferential direction of the rod. In still another embodiment, the positioning portion may not be provided. For example, when designing the powder measuring rod, its structure and center of gravity can be considered so that when the opening direction of the dose slot is in the vertical direction, the powder measuring rod can automatically be in a balanced state. At this time, stable placement of the powder measuring rod on the horizontal plane can be achieved without the aid of a positioning portion.

[0060] In order to achieve multi-channel testing of the powder or powder mixing testing in the airflow analysis test, different powders need to be accommodated in different powder measuring rods. In view of this, the present application discloses a powder measuring rod assembly in some embodiments. Please refer to Figure 5 , which shows a schematic diagram of the powder measuring rod assembly in an embodiment of the present application. As Figure 5 shown, the powder measuring rod assembly includes a first powder measuring rod 1 and a second powder measuring rod 2. The first powder measuring rod 1 is used to accommodate a preset amount of the first powder, and the second powder measuring rod 2 is used to accommodate a preset amount of the second powder, so as to cooperate with the simulated inhalation device to complete the test operation. For example, the first powder measuring rod 1 and the second powder measuring rod 2 can be respectively configured as the powder measuring rod described in any one of the embodiments such as Figures 1 to 4 and its related descriptions.

[0061] Among them, the first powder or the second powder can be configured as a drug powder for treating asthma or other respiratory inflammatory diseases. In one example, the first powder is configured to contain a bronchodilator as an active pharmaceutical ingredient, and the second powder is configured to contain an anti-inflammatory drug as an active pharmaceutical ingredient.

[0062] In order to enable the operator to distinguish the first powder and the second powder contained in the first powder measuring rod and the second powder measuring rod in the powder measuring rod assembly, in one embodiment, as Figure 5 shown, the letter identification located on the proximal end face of the rod of the first powder measuring rod 1 is configured as the letter A, and the letter identification located on the proximal end face of the rod of the second powder measuring rod 2 is configured as the letter B. Of course, the letter identification located on the proximal end face of the rod of the first powder measuring rod 1 can be configured as the letter C, and the letter identification located on the proximal end face of the rod of the second powder measuring rod 2 can be configured as the letter D. This application does not limit this, as long as the first powder measuring rod and the second powder measuring rod can be distinguished, so as to further distinguish the first powder and the second powder contained therein.

[0063] Further, the preset angle of the identification structure of the first powder measuring rod 1 with respect to the vertical direction of its dose groove 12 is configured to be opposite to the preset angle of the identification structure of the second powder measuring rod 2 with respect to the vertical direction of its dose groove 22. In Figure 5 the shown embodiment, the preset angle of the letter A on the first powder measuring rod 1 with respect to the vertical direction of its dose groove 12 is 45°, and the preset angle of the letter B on the second powder measuring rod 2 with respect to the vertical direction of its dose groove 22 is -45°, and the two directions are opposite.

[0064] In one embodiment, the first powder measuring rod 1 and the second powder measuring rod 2 have different preset lengths, and the preset length of the second powder measuring rod 2 is longer than that of the first powder measuring rod 1. For example, in Figure 5 the shown embodiment, the preset length L 1 of the first powder measuring rod 1 is less than the preset length L 2 of the second powder measuring rod 2. The preset length L 2 of the second powder measuring rod 2 and the preset length L 1 of the first powder measuring rod can differ by any value from 16 mm to 20 mm, such as 16 mm, 16.3 mm, 16.5 mm, 17 mm, 18 mm, 19 mm, 20 mm, etc. Thus, from the visual angle of the operator, the first powder measuring rod 1 is short and thick, and the second powder measuring rod 2 is long and thin. It should be understood that Figure 5 the schematic preset length identification shown is only a schematic illustration, and does not mean that the preset lengths of the rods in the two powder measuring rods must be equal or unequal. For example, the preset length L1 in relation to the preset length L of the second powder measuring rod 2 2 may also be L 1 >L 2 or L 1 =L 2 and so on.

[0065] In one embodiment, the preset angle that the positioning portion of the first powder measuring rod has with respect to the vertical direction of its dose groove is configured to be opposite to the preset angle that the positioning portion of the second powder measuring rod has with respect to the vertical direction of its dose groove. Please refer to Figure 6 and in combination with Figure 5 , wherein, Figure 6 it is shown as a schematic diagram of the proximal end face of the powder measuring rod assembly in one embodiment of the present application. As Figure 6 shown, the preset angle β that the positioning portion 114 of the first powder measuring rod 1 has with respect to the vertical direction of its dose groove 12 is -60°, and the preset angle that the positioning portion 214 of the second powder measuring rod 2 has with respect to the vertical direction of its dose groove 22 is 60°.

[0066] Based on any one or a combination of several of the above differences between the first powder measuring rod and the second powder measuring rod, the operator can easily distinguish the first powder measuring rod 1 from the second powder measuring rod 2, and thus easily distinguish the first powder and the second powder contained therein.

[0067] In order to be able to fill a preset amount of powder into the powder measuring rod, for example, filling the dose groove in the powder measuring rod described in any of the above embodiments with powder so that it contains a preset amount of powder. In some embodiments of the present application, a powder filling device is also disclosed. By providing a receiving cavity and a feeding port on the body, the powder measuring rod can be placed in the receiving cavity and the powder can be filled through the feeding port, and the powder can be accurately filled into the dose groove.

[0068] Please refer to Figure 7 , which is shown as a schematic structural diagram of the powder filling device in one embodiment of the present application from a perspective. As Figure 7 shown, the powder filling device 3 includes a body 31 and a feeding port 32. A receiving cavity 33 is provided on the body 31, and the receiving cavity 33 is used to receive the powder measuring rod. The feeding port 32 is arranged on the body 31 and communicates with the receiving cavity 33. When the powder measuring rod is placed in the receiving cavity 33, the dose groove on the powder measuring rod faces the feeding port 32 so that the powder falls into the dose groove through the feeding port 32. It should be noted here that, in order to distinguish it from the receiving cavities in other subsequent devices or components, in the embodiment, the receiving cavity included in the powder filling device is also referred to as the first receiving cavity.

[0069] As Figure 7As shown, in one embodiment, the body 31 includes a base 311 and a filling portion 312. Among them, the base 311 provides a support foundation. It can also be understood that the filling portion 312 is supported on the base 311. In one embodiment, as Figure 7 shown, the base 311 is configured as a generally cuboid base. Further, it can be flat-shaped to provide stable support. To avoid bumping into the operator, in the example as Figure 7 shown, the edge of the base facing upward is configured as a rounded edge or an edge of an inclined surface.

[0070] In one embodiment, as Figure 7 shown, the filling portion 312 is configured as a generally cuboid main body portion, whose width is smaller than the width of the base 311, and whose height is significantly higher than the height of the base 311. Further, to avoid bumping into the operator, the edges of the base facing upward and on the left and right sides can be configured as rounded edges or edges of inclined surfaces. In some examples, the filling portion 312 and the base 311 can be integrally formed or connected by a fixed connection method. The fixed connection methods include but are not limited to welding, bonding, and mortise and tenon connection. In some other examples, the body of the powder filling device may not distinguish between the base and the filling portion, and the present application does not limit this.

[0071] In one embodiment, as Figure 7 shown, the first accommodating cavity 33 and the feeding port 32 are formed on the filling portion 312 of the body 31. Please refer to Figure 8 , which shows a schematic structural diagram of the powder filling device in another perspective in one embodiment of the present application. As Figure 7 and Figure 8 shown, the first accommodating cavity 33 is formed in the filling portion 312 in a front-to-back through manner, and the feeding port 32 extends along the vertical direction at the top (or upper part) of the filling portion 312 to communicate with the first accommodating cavity 33. To facilitate the powder to fall into the dosing groove, in one example, the feeding port 32 is configured as a hole structure with a continuously decreasing cross-section from top to bottom. For example, it can be a funnel-shaped hole structure, a horn-shaped hole structure, or other hole structures with inclined side walls. Of course, the feeding port can also be set to other shapes as long as the powder can enter the dosing groove.

[0072] In one embodiment, the first receiving cavity 33 includes a rod receiving chamber 331 for inserting the rod of the powder measuring rod. In one example, the rod receiving chamber 331 is formed in the filling portion 312 in a manner that penetrates through from front to back. It should be noted here that in order to distinguish the rod receiving chamber included in the receiving cavity of this device from those of other devices or components, in this embodiment, the rod receiving chamber included in the first receiving cavity is also referred to as the first rod receiving chamber. Similarly, the positioning groove further included in the first receiving cavity in subsequent embodiments is also referred to as the first positioning groove, and no further elaboration will be made when referring to the positioning groove further included in the first receiving cavity later.

[0073] In one embodiment, the depth of the first rod receiving chamber 331 is less than the length of the rod in the powder measuring rod, so that when the rod is inserted, its operating section protrudes from the first rod receiving chamber 331, facilitating the operator to hold the operating section to insert or pull out the powder measuring rod from the first rod receiving chamber 331.

[0074] In one embodiment, the first rod receiving chamber 331 has a size that fits snugly with the rod of the powder measuring rod, so that when the rod is taken out, the first rod receiving chamber 331 blocks more than a preset amount of powder from being carried out by the rod. That is to say, the diameter of the first rod receiving chamber 331 is basically the same as that of the rod. After the powder is filled into the dose groove of the powder measuring rod from the feed port 32, when the operator holds the operating section to take out the rod, due to the limitation of the sizes of the first rod receiving chamber 331 and the rod, the first rod receiving chamber 331 acts like a scraper to scrape off more than a preset amount of powder from the rod. In this way, the operator does not need to accurately weigh the mass of the powder to be filled, and only needs to roughly fill the powder into the dose groove to ensure the accuracy of the amount of the filled powder, thereby improving the efficiency of powder filling and further improving the efficiency of the test operation.

[0075] In one embodiment, on the basis of including the first rod receiving chamber 331, the first receiving cavity 33 may further include a first positioning groove 332. The first positioning groove 332 is provided in the circumferential direction of the first rod receiving chamber 331 and is used to cooperate with the positioning portion of the powder measuring rod so that when the positioning portion is inserted to the end of the first positioning groove 332, the dose groove of the powder measuring rod is aligned with the feed port 32. In other words, the first positioning groove 332 can limit the insertion depth of the powder measuring rod through the cooperation with the positioning portion of the powder measuring rod. When the operator inserts the adapted powder measuring rod into the first receiving cavity 331 by operating the operating section of the powder measuring rod, when the positioning portion reaches the end of the first positioning groove 332, it will no longer be possible to push the powder measuring rod deeper. At this time, the dose groove of the powder measuring rod can just be aligned with the feed port 32, facilitating the operator to insert the powder measuring rod into a suitable position.

[0076] In one embodiment, the first positioning groove 332 is configured to have a preset angle with respect to the vertical direction of the feed port 32, and this preset angle is consistent with the preset angle of the positioning portion on the powder measuring rod with respect to the vertical direction of the dosage groove. For example, when the preset angle between the axial direction of the positioning portion of the powder measuring rod and the vertical direction of the dosage groove is -60°, the preset angle between the axial direction of the first positioning groove 332 of the powder filling device 3 and the vertical direction of the feed port 32 is also -60°; when the preset angle between the axial direction of the positioning portion of the powder measuring rod and the vertical direction of the dosage groove is 60°, the preset angle between the axial direction of the first positioning groove 332 of the powder filling device 3 and the vertical direction of the feed port 32 is also 60°. In this way, on the one hand, it can ensure that when the rod is inserted into the first accommodating cavity 33, the first positioning groove 332 fits with the positioning portion to play a positioning role for the powder measuring rod; on the other hand, it can prevent the operator from inserting a powder measuring rod that is not adapted to the powder filling device 3 into the first accommodating cavity 33, thereby avoiding the operator from filling the powder incorrectly. For example, when the preset angle between the axial direction of the first positioning groove 332 of the powder filling device 3 and the vertical direction of the feed port 32 is -60°, the operator cannot insert a powder measuring rod with a preset angle of 60° between the axial direction of the positioning portion and the vertical direction of the dosage groove into the first accommodating cavity 33.

[0077] In one embodiment, the depth of the first positioning groove 332 is configured to adapt to the dimensional information of the feed port, the positioning portion of the powder measuring rod, and the dosage groove. While restricting the angle of the first positioning groove 332, its depth is also restricted so that when the powder measuring rod is inserted into the first accommodating cavity 33, the dosage groove on the powder measuring rod is exactly aligned with the feed port 32 on the powder filling device 3, that is, the axis where the opening of the dosage groove is located coincides with the axis of the feed port, so as to facilitate the accurate filling of the powder from the feed port 32 into the dosage groove. In a preferred example, the depth of the first positioning groove 332 is configured to be 10 mm.

[0078] In Figure 7 In the embodiment shown, an identification structure 35 is configured on the body 31 of the powder filling device 3. The identification structure 35 is used to indicate the type of the powder filling device. The type of the powder filling device refers to different powder filling devices. Further, the identification structure 35 can distinguish the types of powders to be filled.

[0079] The identification structure includes but is not limited to visual identifications such as color identification, number identification, letter identification, or any combination of the above identifications. The ways of configuring the identification structure on the body include but are not limited to pasting, engraving, labeling, laser engraving, and digital display screens. Further, for the convenience of the operator's observation, the identification structure can be configured on the end face of the proximal end of the body.

[0080] In an embodiment where the identification structure is configured as a letter identification, when different powders need to be filled into different powder measuring rods, the letter can conveniently provide a visual indication to the operator. By observing the letter, the operator can determine which powder needs to be filled into the feed port to avoid confusion. For example, as Figure 7 shown, the letter identification A on the proximal end face of the body 31 of the powder filling device 3 can indicate to the operator to fill the first powder into the feed port 32, and the letter identification B on the proximal end face of the body of another powder filling device can indicate to the operator to fill the second powder into its feed port. Thus, the operator can distinguish the two powders to be filled through the letters A and B.

[0081] Of course, the identification structure can be provided at any position of the powder filling device as long as the operator can clearly realize the type of powder to be filled. The present application does not impose any restrictions on this.

[0082] The following takes the powder measuring rod 1 configured as shown in Figure 2 as an example to illustrate the operation process of filling it into the powder filling device shown in Figure 7 as follows.

[0083] First, the operator grasps the operation section 111 on the powder measuring rod 1 and inserts the rod body 110 into the first rod receiving chamber 331 of the powder filling device 3 with the letter identification A that is consistent with the letter identification A on the powder measuring rod 1. During this process, the positioning portion 114 on the powder measuring rod 1 is aligned with the first positioning groove 332 on the powder filling device 3 and inserted to the deepest. At this time, the dose groove 12 on the powder measuring rod 1 is exactly aligned with the feed port 32 on the powder filling device 3, waiting for the operator to perform subsequent powder filling operations.

[0084] In order to recover the excess powder after filling and avoid waste of powder, please refer to Figure 9 , which shows a schematic structural diagram of the powder filling device with a tray configured in an embodiment of the present application. As shown in the figure, the powder filling device 3 further includes a tray receiving chamber 34 for inserting a tray 5 to receive the excess powder. Further, the tray receiving chamber 34 can be configured to extend from an opening on the distal end face of the body 31 into the interior of the body 31. The opening is located below the first accommodation chamber 33 and communicates with the first accommodation chamber 33. Specifically, for example, a through hole G can be provided at the bottom of the first accommodation chamber 33, and the tray receiving chamber 34 is communicated with the first accommodation chamber 33 by means of the through hole G. In this way, when the tray 5 is placed in the tray receiving chamber 34, the powder receiving part on the tray 5 just faces the through hole G. When the powder measuring rod is taken out after filling the powder through the feed port 32, the excess powder can fall into the powder receiving part of the tray 5 through the through hole G.

[0085] In one embodiment, as Figure 8 shown, the tray receiving chamber 34 includes a first anti-misassembly structure 341. For example, the first anti-misassembly structure 341 can be configured as a recessed area formed by the lower sidewall of the tray receiving chamber 34, and the opening of the recessed area forms a part of the opening on the tray receiving chamber 34, so that the mating part on the tray 5 can be inserted.

[0086] Please continue to refer to Figure 9 , the tray 5 includes a tray body 52, and the tray body 52 is inserted through the opening of the tray receiving chamber 34. Further, the tray 5 may further include a second anti-misassembly structure 51 adapted to the first anti-misassembly structure 341. The second anti-misassembly structure 51 is disposed below the tray body 52. In Figure 9 the example shown, the second anti-misassembly structure 51 is configured as a bump structure at the bottom of the tray body 52.

[0087] As shown in Figure 9 , the second anti-misassembly structure 51 is adapted to the first anti-misassembly structure 341, so that the tray 5 can be inserted into the tray receiving chamber 34 only in a proper manner, thereby preventing the operator from making an incorrect installation. Specifically, when the operator installs the tray 5 into the tray receiving chamber 34, the bump structure corresponding to the second anti-misassembly structure 51 on the tray 5 needs to be combined with the recess corresponding to the first anti-misassembly structure 341 of the tray receiving chamber 34.

[0088] In other embodiments, the first anti-misassembly structure 341 and the second anti-misassembly structure 51 can also be configured as devices capable of emitting sound or light prompts. When the tray 5 is correctly inserted into the tray receiving chamber 34, the first anti-misassembly structure 341 or the second anti-misassembly structure 51 can emit a certain color of light or emit a specific sound to indicate a correct operation and improve the operator's perception during the operation.

[0089] In one embodiment, as Figure 9 shown, the tray body 52 may further include an operation part 521 and a powder receiving part 522. The operator can insert the tray 5 into the tray receiving chamber 34 by grasping or holding the operation part 521. When the tray 5 is inserted into the tray receiving chamber 34 through the opening of the tray receiving chamber 34, the operation part 521 protrudes from the tray receiving chamber 34 for the operator to operate. Of course, the operation part 521 may not be provided, and the operator can directly grasp the tray body 52.

[0090] In one embodiment, the powder receiving portion 522 may be provided as a groove away from the operating portion 521 to collect excess powder. Further, the groove is provided on the end face above the tray body 52. When the tray 5 is inserted into the tray receiving chamber 34, the powder receiving portion 522 is opposite to the feed port 32. After the operator inserts the powder measuring rod for powder filling and then removes the powder measuring rod, due to the limitation of the size of the first rod receiving chamber 331 and the rod, more than the preset amount of powder is scraped off the rod by the first rod receiving chamber 331 and thus can enter the powder receiving portion 522 of the tray 5 for reuse.

[0091] To achieve filling different powders in different powder measuring rods, the present application discloses a powder filling assembly in some embodiments. Please refer to Figure 10 , which shows a schematic diagram of the powder filling assembly in one embodiment of the present application. As Figure 10 shown, the filling device assembly includes a first powder filling device 3 and a second powder filling device 4. The first powder filling device 3 is matched with the first powder measuring rod and is used to fill the first powder into the first powder measuring rod; the second powder filling device 4 is matched with the second powder measuring rod and is used to fill the second powder into the second powder measuring rod. For example, the first powder measuring rod and the second powder measuring rod can be respectively configured as the powder measuring rods described in any of the embodiments such as Figures 1 to 6 and its related descriptions; the first powder filling device 3 and the second powder filling device 4 can be respectively configured as the powder filling devices described in any of the embodiments such as Figures 7 to 8 and its related descriptions. More specifically, when the first powder measuring rod is configured as the first powder measuring rod 1 as Figure 5 shown, the first powder filling device 3 is configured as the first powder filling device 3 as Figure 7 shown; when the second powder measuring rod is configured as the second powder measuring rod 2 as Figure 5 shown, the second powder filling device 4 is configured as the second powder filling device 4 as Figure 10 shown.

[0092] To enable the operator to distinguish which powder needs to be filled into the first powder filling device and the second powder filling device (it can also be understood as distinguishing the powder measuring rods respectively adapted to the first powder filling device and the second powder filling device), in one embodiment, the identification structure of the first powder filling device 3 is matched with the identification structure of the first powder measuring rod, and the identification structure of the second powder filling device is matched with the identification structure of the second powder measuring rod. Specifically, in the embodiment where the identification structure is configured as a letter identification, such as Figure 10 and Figure 5As shown, when the letter identification 115 of the first powder measuring rod 1 is configured as the letter A, the letter identification 35 of the first powder filling device 3 is also configured as the letter A; when the letter identification 215 of the second powder measuring rod 2 is configured as the letter B, the letter identification 45 of the second powder filling device 4 is also configured as the letter B.

[0093] In one embodiment, the preset angle of the first positioning groove of the first powder filling device relative to the vertical direction of its feed port is configured to be opposite to the preset angle of the positioning groove of the second powder filling device relative to the vertical direction of its feed port. Figure 10 and Figure 5 In the example shown, the preset angle of the first positioning groove 332 of the first powder filling device 3 relative to the vertical direction of the feed port 32 is -60° to match the first powder measuring rod 1; the preset angle of the positioning groove 432 of the second powder filling device 4 relative to the vertical direction of its feed port 42 is 60° to match the second powder measuring rod 2.

[0094] The operation of filling the second powder into the second powder measuring rod 2 using the second powder filling device 4 is the same as the operation of filling the first powder into the first powder measuring rod 1 using the first powder filling device 3. The following Figure 5 and Figure 10 Take the filling of the first powder as an example for detailed description:

[0095] When filling the first powder into the first powder measuring rod 1 using the first powder filling device 3, the operator first holds the operation part 521 of the tray 5 and inserts the second anti-fooling structure 51 into the first anti-fooling structure 341 at the distal end of the first powder filling device 3 to complete the installation of the tray 5. At this time, the powder receiving part 522 is inside the first powder filling device 3 and is facing the feed port 32 directly, while the operation part protrudes from the tray receiving chamber 34; then, the operator holds the gripping part 113 of the first powder measuring rod 1 and inserts the positioning part on the first powder measuring rod 1 into the first positioning groove 332 at the proximal end of the first powder filling device 3 to complete the installation of the first powder measuring rod 1. At this time, the dose groove 12 on the first powder measuring rod 1 is aligned with the feed port 32 on the first powder filling device 3; then, the operator fills the first powder into the feed port 32 and gently taps the first powder filling device 3 so that the first powder falls to the bottom of the dose groove 12 and fills the dose groove 12; after that, the operator holds the gripping part 113 of the first powder measuring rod 1 and pulls out the first powder measuring rod 1 from the first receiving cavity 33; finally, holds the operation part of the tray 5 and pulls out the tray 5 from the first powder filling device 3 to recover the first powder in the powder receiving part 522.

[0096] After the powder is filled into the powder measuring rod, due to the extremely light weight of the powder particles themselves, they are extremely vulnerable to the influence of the environment. For example, when the air flows, the powder is extremely likely to fly, resulting in the loss of the powder, leading to inaccurate powder dosage during analysis and testing. Moreover, impurities in the air will enter the powder, causing powder contamination. In view of this, in some embodiments provided in the present application, a transfer device is also disclosed, which is suitable for storing or transferring the powder measuring rod, and the powder measuring rod is, for example, the powder measuring rod described in any of the foregoing embodiments. Further, the transfer device is provided with a receiving cavity for receiving the powder measuring rod on the base, so that the receiving cavity can wrap the dosage groove of the powder measuring rod, avoiding the direct contact between the powder contained in the dosage groove and the air, thereby avoiding the loss and contamination of the powder, and further ensuring the accuracy of the analysis and testing. In addition, the transfer device also locks the operating section of the powder measuring rod by setting a frame that can be in a locked state, so that the powder measuring rod can be stored on the base or transferred with the base, and will not be accidentally pulled out or fall off, thereby enhancing the safety of storing or transferring the powder measuring rod.

[0097] Please refer to Figure 11 and Figure 12 , Figure 11 which shows a schematic structural view of the transfer device in an embodiment of the present application, Figure 12 and shows a disassembled structural view of the transfer device in an embodiment of the present application. Figure 11 It is described with the powder measuring rod 1 disposed in the transfer device 6, as shown in Figure 11 and Figure 12 . As shown, the transfer device 6 includes a base 61 and a frame 62. The base 61 is provided with a receiving cavity 611 for receiving the powder measuring rod. When the powder measuring rod is inserted into the receiving cavity 611, its operating section 111 protrudes from the receiving cavity 611 for operation (as shown in Figure 11 ). It should be noted here that, in order to distinguish it from the receiving cavities in other subsequent devices or components, in the embodiment, the receiving cavity included in the transfer device is also referred to as the second receiving cavity.

[0098] As shown in Figure 11 and Figure 12 , the frame 62 is used to support the base 61 and can move relative to the base 61 to lock the powder measuring rod. When the powder measuring rod is in the locked state, its operating section 111 is inoperable, so that the powder measuring rod can be stored on the base 61 or transferred with the base 61. Among them, the frame 62 can move relative to the base 61 means that relative movement can be generated between the base 61 and the frame 62. It can be that only the base 61 is operated to move, or only the frame 62 is operated to move, or both the base 61 and the frame 62 are operated to move.

[0099] Among them, the inoperability of the operation section 111 of the powder measuring rod in the locked state means that the operator cannot take out the powder measuring rod by operating the operation section 111. For example, the frame 62 may block part or all of the area of the operation section 111, making it difficult for the operator to act on the operation section 111, or the frame 62 may obstruct the moving path of the operation section 111, so that even if the operator can touch the operation section 111, they cannot move it. In other words, in the locked state, the operation section of the powder measuring rod can be touched or not touched by the operator, as long as the powder measuring rod cannot be withdrawn from the second receiving cavity of the transfer device.

[0100] In one embodiment, as Figure 12 shown, the base 61 is configured as a generally cuboid structure, and further, it can be elongated, so that a plurality of second receiving cavities can be configured. To avoid bumping into the operator, in the example as Figure 12 shown, the edges of the base facing upward and the left and right sides are configured as rounded edges or edges of inclined surfaces.

[0101] In one embodiment, the opening of the second receiving cavity 611 on the end face at the front end of the base 61 extends inward, and the powder measuring rod 1 is inserted into the base 61 through the opening. As Figure 12 shown, the second receiving cavity 611 includes a rod receiving chamber 6111 and a positioning groove 6112. It should be noted here that, in order to distinguish the rod receiving chamber included in the second receiving cavity from the rod receiving chambers included in other devices or components, in the embodiment, the rod receiving chamber included in the second receiving cavity is also referred to as the second rod receiving chamber. Similarly, the positioning groove further included in the second receiving cavity in the subsequent embodiments is also referred to as the second positioning groove, and it will not be repeated when referring to the positioning groove further included in the second receiving cavity later.

[0102] The second rod receiving chamber 6111 is for the rod of the powder measuring rod to be inserted. The second positioning groove 6112 is provided in the circumferential direction of the second rod receiving chamber 6111 and is used to cooperate with the positioning portion of the powder measuring rod to limit the insertion depth of the powder measuring rod.

[0103] In one embodiment, the second positioning groove 6112 is configured to have a preset angle with respect to the vertical direction of the horizontal plane where the base 61 is located, and this preset angle is consistent with the preset angle of the positioning portion of the powder measuring rod with respect to the vertical direction of the dosage groove. That is, the preset angle that the second positioning groove 6112 has with respect to the vertical direction of the horizontal plane where the base 61 is located is configured to be -60° or 60°. It can be understood that when the axial direction of the positioning portion of the powder measuring rod and the vertical direction of the dosage groove have a preset angle of -60°, the axial direction of the second positioning groove 6112 of the transfer device 6 and the vertical direction of the horizontal plane where the base 61 is located also have a preset angle of -60°; when the axial direction of the positioning portion of the powder measuring rod and the vertical direction of the dosage groove have a preset angle of 60°, the axial direction of the second positioning groove 6112 of the transfer device 6 and the vertical direction of the horizontal plane where the base 61 is located also have a preset angle of 60°, and the vertical direction of the dosage groove and the vertical direction of the horizontal plane where the base 61 is located are in the same direction. Only in this way can it be ensured that when the rod is inserted into the second receiving cavity 611, the second positioning groove 6112 fits with the positioning portion to play a role in positioning the powder measuring rod.

[0104] In one embodiment, the depth of the second rod receiving chamber 6111 is less than the length of the rod of the powder measuring rod, so that when the rod is inserted, its operating section protrudes from the second rod receiving chamber 6111. In order to ensure that when the rod is inserted into the second receiving cavity 611, the operating section on the powder measuring rod protrudes from the second receiving cavity 611, the depth of the second positioning groove 6112 can be limited. In a preferred example, the depth of the second positioning groove 6112 is configured to be 14 mm.

[0105] Specifically, when inserting any powder measuring rod, the operator needs to align the positioning portion on the powder measuring rod with the second positioning groove on the transfer device through the holding portion on the powder measuring rod and insert it to the deepest, so as to insert the rod of the powder measuring rod into the second rod receiving chamber of the transfer device.

[0106] To achieve the storage or transfer of multiple first powder measuring rods, in one embodiment, as Figure 11 and Figure 12 shown, the second receiving cavity 611 can be configured as a plurality of arranged side by side. In one implementation, the second receiving cavity 611 is configured as 6, 7, 8, 9, 10, 11, 12, 13, 14; preferably, the second receiving cavity 611 is configured as 10.

[0107] Furthermore, in order to facilitate the operator to distinguish multiple second receiving cavities, in one embodiment, as Figure 11 and Figure 12As shown, a quantity identifier is provided on the upper surface of the base 61. Specifically, the numbers 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 are sequentially provided on the upper surface directly above the base 61 corresponding to the 10 second receiving cavities 611 from left to right.

[0108] In order to indicate the type of the transfer device, in one embodiment, an identification structure is configured on the base of the transfer device. The type of the transfer device refers to different transfer devices. Further, the identification structure on the base can distinguish the types of powders contained in the second receiving cavities. The identification structure includes, but is not limited to, color identification, number identification, letter identification, or visual identification of any combination of the above identifications. The manner in which the identification structure is configured on the base includes, but is not limited to, pasting, engraving, labeling, laser engraving, and digital display screens. Further, for the convenience of the operator to observe, the identification structure can be configured at the middle position of the upper surface of the base.

[0109] In the embodiment where the identification structure is configured as letter identification, when the operator needs to distinguish the types of the inserted powder measuring rods and thus distinguish the types of powders contained in the second receiving cavities, the operator can achieve the above purpose by observing the letters to avoid confusion. For example, as Figure 12 shown, the letter identification A on the upper surface of the base 61 of the transfer device 6 can indicate to the operator to insert the powder measuring rod with the letter A on the end face, such as the first powder measuring rod, into the second receiving cavity 611; the letter identification B on the upper surface of the base 61 of the transfer device 6 can indicate to the operator to insert the powder measuring rod with the letter B on the end face, such as the second powder measuring rod, into the second receiving cavity 611. Thus, the operator can distinguish the types of the inserted powder measuring rods in the second receiving cavity 611 and further distinguish the first powder and the second powder.

[0110] As Figure 12 shown, the frame 62 further includes a support portion 621 and a blocking portion 622. A moving channel 623 is provided on the support portion 621. The base 61 is supported in the moving channel 623 and can move relative to the support portion 621 along with the moving channel. The blocking portion 622 is fixedly provided on the support portion 621 and is located on the operable path of the operating section of the powder measuring rod when the base 61 moves relative to the support portion 621 to the terminal of the moving channel 623 to prevent the operation of the operating section.

[0111] In one embodiment, the moving channel 623 is configured as an inverted L shape so that the base 61 can move horizontally and vertically relative to the support portion 621 along with the moving channel 623. The following combination with Figure 13Taking (a) to (c) in [specific context] as an example where the moving channel 623 is configured as an inverted L shape, the movement of the base 61 in response to the movement generated by the moving channel 623 relative to the support portion 621 will be described.

[0112] Please refer to Figure 13 , which shows a schematic diagram of the process of the frame moving relative to the base to lock the powder measuring rod in an embodiment of the present application, as shown in Figure 13 a, the transfer device 6 is in an initial state. The initial state means that the operator can operate the operation section 111 of the powder measuring rod 1 to move on its operable path. That is, the operator can insert or remove the 10 powder measuring rods as shown in Figure 13 a into or from the corresponding 10 second receiving cavities in sequence. Of course, the operator does not have to insert or remove exactly the same number of powder measuring rods as the number of second receiving cavities of the transfer device. The operator can insert or remove fewer or the same number of powder measuring rods as the number of second receiving cavities of the transfer device according to the application scenario.

[0113] As shown in Figure 13 b and Figure 13 c, the base 61 and the frame 62 in the transfer device 6 can move relative to each other. Specifically, as shown in Figure 13 b, the operator moves the frame 62 forward, causing the base 61 to move relative from the starting end of the horizontal structure in the inverted L-shaped structure of the moving channel 623 to the terminal end of the horizontal structure (i.e., the starting end of the vertical structure in the inverted L-shaped structure). Then, as shown in Figure 13 c, the operator moves the frame 62 upward, causing the base 61 to move relative from the starting end within the vertical structure of the inverted L-shaped structure to the terminal end state. That is, the base 61 has relative displacements in the front-back direction and the up-down direction relative to the frame 62. At this time, the blocking portion 622 on the frame 62 moves along with the frame and is located on the operable path of the operation section of the powder measuring rod, thereby preventing the operator from operating the operation section.

[0114] Furthermore, to ensure that the blocking portion 622 can remain in the position blocking the operable path, as shown in Figure 13 d, the transfer device 6 can be further fixed in a locked state. For example, the operator can operate the frame 62 to keep it in the locked state. The structure and process of fixing the transfer device 6 in the locked state will be described in detail later.

[0115] In other embodiments, the moving channel 623 can also be configured in other structural shapes. For example, the moving channel 623 is configured as a vertical structure so that the base 61 longitudinally moves relative to the support part along the moving channel. At this time, the operator first inserts the powder measuring rod into the second receiving cavity in sequence, and then operates the frame to move it to the terminal within the vertical structure of the moving channel 623, so that the blocking part is located on the operable path of the operating section of the powder measuring rod to prevent the operator from inserting or pulling out the operating section.

[0116] In one embodiment, as Figure 12 shown, the support part 621 includes a first support frame 6211 and a second support frame 6212 arranged oppositely. The moving channel 623 is configured on the first support frame 6211 and the second support frame 6212. For example, two moving channels 623 can be configured, respectively, on the opposite side walls of the first support frame 6211 and the second support frame 6212. The base 61 can move relatively across between the first support 6211 and the second support frame 6212 through the connecting part 6213. Specifically, one connecting part 6213 can be passed through the moving channel 623 on the first support frame 6211 to be connected to the base 61, and the other connecting part 6213 can be passed through the moving channel 623 on the second support frame 6212 to be connected to the base 61. In some examples, as Figure 12 shown, the first support frame 6211 and the second support frame 6212 can be configured as convex-shaped plate structures. In some examples, the connecting part 6213 can be, for example, a bolt or a screw. Correspondingly, corresponding screw holes are provided on the base 61. Specifically, the size of the nut part of the connecting part 6213 is larger than the width of the moving channel. When the connecting part is connected to the base, the connecting part interacts with the screw holes on the base. Due to the size limitation of the nut part, the base is positioned within the moving channel 623 between the first support frame 6211 and the second support frame 6212 and will not fall off from the moving channel.

[0117] In one embodiment, the support part 621 further includes a reinforcing plate 6214. The reinforcing plate 6214 is connected between the first support frame 6211 and the second support frame 6212 and is used to increase the strength of the support part 621. In Figure 12 the shown example, the reinforcing plate 6214 is arranged at the distal end of the transfer device 6. Its shape and size are completely matched with the structural surface of the support part. Its materials include, but are not limited to, composite materials, metal plates, and glass fiber-reinforced polymers. The connection manner between the reinforcing plate 6214 and the support part 621 includes adhesion, bolts, screws, or other mechanical connection manners to ensure a firm and reliable fixing manner.

[0118] In one embodiment, the blocking portion 622 is configured as a flat structure straddling the first support frame 6211 and the second support frame 6212, and is movably engaged with the base 61 within the movement channel 623 to block the operating section of the powder measuring rod. In Figure 1 and Figure 12 In the example shown, the blocking portion 622 is disposed at the proximal end of the transfer device 6. The blocking portion 622 can be connected to the first support frame 6211 and the second support frame 6212 by means of adhesion, bolts, screws or other mechanical connection means to ensure a firm and reliable fixing method.

[0119] In one embodiment, the frame 62 further includes a holding portion 624. An operator operates the holding portion 624 to move the frame 62 relative to the base 61. To leave a certain operating space for the operator, the holding portion 624 is disposed at the top of the frame 62, connecting the tops of the first support frame and the second support frame, and having a certain distance from the installation position of the base 61. The holding portion 624 can be connected to the first support frame 6211 and the second support frame 6212 by, but not limited to, adhesive connection, welding and mortise and tenon connection.

[0120] In one embodiment, the frame 62 further includes a locking portion 625. The locking portion 625 is used to lock the blocking portion 622 to maintain the operable path of the operating section of the powder measuring rod. In Figure 12 In the example shown, the holding portion 624 is rotatably connected to the support portion 621, and the locking portion 625 is fixed to the holding portion 624. The operator rotates the holding portion 624 to lock the blocking portion 622. The locking portion 625 is configured as a plate-like structure fixed to the holding portion 624, and its length is slightly smaller than the distance between the upper surface of the base 61 and the holding portion 624 when the operating section of the powder measuring rod is locked.

[0121] Please combine Figure 13 , when using the locking portion 625 to change the powder measuring rod from the initial state as shown in Figure 13 a to the locked state as shown in Figure 13 d, the operator moves the frame 62 forward by operating the holding portion 624 of the transfer device 6, causing the base 61 to move laterally along the connecting portion 6213 on the movement channel 623 to Figure 13 the state shown in b. Then, the operator operates the holding portion 624 to pull the frame upward relative to the base 61, and rotates the holding portion 624 in the clockwise direction so that the locking portion 625 connected to the holding portion 624 is vertically located above the base 61. At this time, the base 61 moves longitudinally along the connecting portion 6213 on the movement channel 623 to Figure 13The moving state shown in c. Finally, the operator can operate the holding part 624 to lower the frame (or directly release the holding part 624 so that the frame falls under its own gravity). At this time, the locking part 625 touches the upper surface of the base 61, forming as Figure 13 shown in d.

[0122] In another embodiment, the locking part 625 is used to unlock the blocking part 622 from the operable path of the operation section of the powder measuring rod. In Figure 12 the example shown, the holding part 624 is rotatably connected to the support part 621, and the locking part 625 is fixed to the holding part 624. The operator unlocks the blocking part 622 by rotating the holding part 624. Please refer to Figure 13 , when the operator needs to take out the powder measuring rod in the transfer device for testing, it is necessary to use the locking part 625 to change the powder measuring rod from the locked state shown in Figure 13 d to the initial state shown in Figure 13 a. Specifically, the operator needs to rotate the holding part 624 counterclockwise to unlock the blocking part 622, and lower the frame 62 so that the blocking part 622 of the transfer device 6 leaves the operable path of the operation section, forming the state shown in Figure 13 b. Then, the operator operates the holding part 624 to move the frame 62 backward relative to the base 61, forming the state shown in Figure 13 a. At this time, the operator can take out the powder measuring rod.

[0123] The following will be described in detail with reference to Figure 13 the operations required for storing or transferring the powder measuring rod using the transfer device 6. The operator aligns the positioning part on the powder measuring rod with the second positioning groove 6112 on the transfer device 6 through the holding part on the powder measuring rod and inserts it to the deepest, so as to insert the rod of the powder measuring rod into the second rod receiving chamber 6111 of the transfer device 6. The operator completes the insertion of each powder measuring rod according to this method, and connects the connecting part 6213 on the base 61 and the frame 62, forming the initial state shown in Figure 13 a; then, the operator operates the holding part 624 of the transfer device 6 to move the frame 62 forward relative to the base 61, and the connecting part 6213 moves accordingly, forming the moving state shown in Figure 13 b; thereafter, the operator operates the holding part 624 to pull the frame 62 upward relative to the base 61, and rotates the holding part 624 clockwise so that the locking part 625 fixedly connected to the holding part 624 is vertically above the base 61, forming the moving state shown in Figure 13 c; finally, the operator places the transfer device on a horizontal plane so that the locking part 625 falls on the base 61, forming the state shown in Figure 13The locking state shown in d is achieved to store or transfer the powder measuring rod.

[0124] When it is necessary to take out the powder measuring rod from the transfer device for analysis and testing, the unlocking step of the powder measuring rod is opposite to the above-mentioned locking step, which will not be elaborated here.

[0125] As mentioned above, when it is necessary to perform an air flow analysis test on the mixture of two powders, a powder measuring rod assembly needs to be set up. The powder measuring rod assembly includes a first powder measuring rod and a second powder measuring rod. To match it and respectively achieve the storage or transfer of the first powder measuring rod and the second powder measuring rod, in some embodiments of the present application, a transfer assembly is disclosed. The transfer assembly includes a first transfer device and a second transfer device. The first transfer device is used to store or transfer the first powder measuring rod, and the second transfer device is used to store or transfer the second powder measuring rod. For example, the first powder measuring rod and the second powder measuring rod can be respectively configured as the powder measuring rod described in any embodiment of Figures 1 to 6 and its related descriptions; the first transfer device and the second transfer device can be respectively configured as the transfer device described in any embodiment of Figures 11 to 13 and its related descriptions.

[0126] In order to enable the operator to distinguish which powder measuring rod is accommodated in the first transfer device and the second transfer device, and further distinguish which powder is stored or transferred, in one embodiment, the identification structure of the first transfer device matches the identification structure of the first measuring rod, and the identification structure of the second transfer device matches the identification structure of the second measuring rod. Specifically, in the embodiment where the identification structure is configured as a letter identification, when the letter identification of the first powder measuring rod is letter A, the letter identification of the first transfer device is also letter A; when the letter identification of the second powder measuring rod is letter B, the letter identification of the second transfer device is also letter B, so that the operator can distinguish the first powder and the second powder in the transfer device according to letter A and letter B.

[0127] In one embodiment, the preset angle of the positioning groove of the first transfer device with respect to the vertical direction of the horizontal plane is configured to be opposite to the preset angle of the positioning groove of the second transfer device with respect to the vertical direction of the horizontal plane. For example, when the preset angle of the positioning groove of the first transfer device with respect to the vertical direction of the horizontal plane is -60°, the axis direction of the positioning part of the corresponding first powder measuring rod with respect to the vertical direction of the dosing groove is also -60°; when the preset angle of the positioning groove of the second transfer device with respect to the vertical direction of the horizontal plane is 60°, the axis direction of the positioning part of the corresponding second powder measuring rod with respect to the vertical direction of the dosing groove is also 60°.

[0128] In order to cooperate with the powder measuring rod for powder dispensing and form an air flow, for example, to perform an air flow analysis test on a preset amount of powder contained in the dose slot of the powder measuring rod described in any of the foregoing embodiments, in some embodiments of the present application, a simulated inhalation device is also disclosed. By providing a manifold on the main body, the distribution and guidance of the air flow are achieved; by providing a receiving cavity on the main body, the powder measuring rod can be placed in the receiving cavity and the dose slot can be connected to the chamber inlet of the manifold, thereby forming an air flow carrying the powder.

[0129] Please refer to Figure 14 , which shows a schematic structural diagram of the simulated inhalation device in an embodiment of the present application. As shown in the figure, the simulated inhalation device 8 includes a main body 81 and a receiving cavity 82. A manifold ( Figure 14 not shown in the figure) is arranged on the main body 81, and the manifold is used for splitting the air flow and guiding the air flow direction. The receiving cavity 82 is arranged on the main body 81 to receive the powder measuring rod. The receiving cavity 82 is communicated with the manifold so that when the powder measuring rod is docked in the receiving cavity, the dose slot of the powder measuring rod is communicated with the manifold, so that the air flow can carry the powder in the dose slot and be distributed through the manifold. It should be noted here that in order to distinguish it from the receiving cavities in other devices or components, in the embodiment, the receiving cavity included in the simulated inhalation device is also referred to as the third receiving cavity.

[0130] In one embodiment, as Figure 14 shown, the main body 81 is configured as a box-shaped structure generally in the shape of a cuboid. In order to avoid bumping into the operator, in the example as Figure 14 shown, the edges of the main body 81 facing all directions are configured as rounded edges or edges with inclined surfaces.

[0131] Please refer to Figure 15 , and in combination with Figure 14 , wherein, Figure 15 shows a cross-sectional schematic diagram of the manifold arranged in the main body in an embodiment of the present application. As shown in FIGS. 15 and Figure 14 shown, a distribution cavity 83 is provided on the main body 81, and the manifold 9 is arranged in the distribution cavity 83. The distribution cavity 83 can be configured as a groove opened in the middle area of the main body 81 and having an opening facing the top surface of the main body 81 and an opening facing the side surface of the main body 81, and its shape is adapted to the manifold for the manifold to enter.

[0132] In one embodiment, the distribution chamber 83 has an air inlet for the air flow to enter the manifold 9. For example, the air inlet can be an opening on the side surface of the distribution chamber 83 facing the main body portion 81. A positioning mechanism 84 for holding the manifold 9 in the distribution chamber is provided on the air inlet. The positioning mechanism 84 is arranged on the end surface of one side of the main body portion 81 and is provided with an air intake structure corresponding to the air inlet so that the air flow can enter the air inlet. In Figure 14 the illustrated example, the air intake structure is configured as a grid 841 formed on the positioning mechanism 84. On the one hand, the grid structure helps to achieve uniform air flow distribution, thus avoiding the formation of a non-uniform flow field near the air inlet and ensuring that each area can receive relatively uniform air flow. On the other hand, it helps to prevent pollutants in the air from entering the simulated inhalation device and being tested with the air flow, thereby ensuring the accuracy of the test results. In another example, the air intake structure can be configured as an orifice plate structure formed on the positioning mechanism, that is, a plurality of uniformly distributed small holes are provided on the positioning mechanism, so that the air flow generates uniform air flow when passing through the orifice plate structure.

[0133] In one embodiment, as Figure 14 shown, the positioning mechanism 84 includes a positioning plate 842 and a fixing mechanism 843. The positioning plate 842 is detachably blocked on the air inlet through the fixing mechanism 843. It should be understood that when the positioning plate 842 is fixedly blocked on the air inlet, the manifold fixed in the main body portion 81 can be fixed; when the positioning plate 842 is disassembled at the air inlet, the manifold can be removed from the main body portion 81, so that cleaning can be carried out after the test.

[0134] In one implementation manner, as Figure 14 shown, a first engaging portion 8421 is provided on the positioning plate 842. The fixing mechanism 843 is connected to the main body portion 81 and is configured with a second engaging portion 8431. The fixing mechanism 843 is rotated so that the second engaging portion 8431 engages or releases the first engaging portion 8421. It should be understood that the engagement can refer to a state where the second engaging portion 8431 and the first engaging portion 8421 are locked to each other and cannot move relative to each other, and the release can refer to a state where the second engaging portion 8431 releases the locking of the first engaging portion 8421 so that it can be disassembled from the main body portion.

[0135] The fixing mechanism includes at least one fixing member, and the fixing member is configured as an eccentric bolt screwed on the main body portion 81. At this time, the second engaging portion 8431 is configured as the head of the eccentric bolt. The eccentric bolt includes a head and a rod portion. In one embodiment, the rod portion is arranged at a position deviating from the center of the head; in another embodiment, the head is set as a quasi-circular shape including a straight edge, and the rod portion is connected to the main body portion 81. Specifically, as Figure 14As shown, the first engaging portion 8421 is configured to be located in the grooves on both sides of the positioning plate 842. The grooves cooperate with the heads of the eccentric bolts to complete the installation and disassembly of the positioning plate 842 at the air inlet. Specifically, when the straight edge of the head of the eccentric bolt rotates to the position of the groove of the first engaging portion and is parallel to the groove, the positioning plate 842 can be disassembled from the air inlet; when the straight edge of the head of the eccentric bolt moves away from the groove position of the first engaging portion, the positioning plate 842 is fixed to the main body of the simulated inhalation device.

[0136] Please refer to Figures 14 to 17 , wherein Figure 16 is shown as a schematic diagram of the release of the fixing mechanism and the positioning plate of the simulated inhalation device in an embodiment of the present application, Figure 17 is shown as a schematic diagram of the engagement of the fixing mechanism and the positioning plate of the simulated inhalation device in an embodiment of the present application. When the installation of the manifold 9 in the distribution chamber 83 is completed, the simulated inhalation device changes from the Figure 14 state to the Figure 15 state shown. Subsequently, the operator needs to install the positioning plate 842 shown in Figure 14 to block the air inlet. The straight edge of the head of the eccentric bolt is directed vertically towards the third receiving chamber. At this time, the positioning plate 842 is installed at the position of the air inlet to form the state shown in Figure 16 ; then the operator manipulates the eccentric bolt until the straight edge of its head moves away from the groove position on the positioning plate to form the state shown in Figure 17 . When disassembling the positioning plate 842 after the test operation is completed, the operator only needs to manipulate the eccentric bolt so that the straight edge of its head is again directed vertically towards the distribution chamber to form the state shown in Figure 16 .

[0137] In one embodiment, the manifold can guide the flow direction of the air flow so that the medicament powder can be pulverized into uniform particles when carried by the air flow, which helps to improve the accuracy of the air flow analysis test. In another embodiment, the manifold can divide the air flow into multiple branches so that the air flow in each branch flows in multiple different specific directions to ensure the uniform distribution of the air flow in the test area, thereby improving the reliability of the test results.

[0138] Please continue to refer to Figure 15 and combine with Figure 14, the manifold 9 includes a chamber 91 which has a chamber inlet 911 and a chamber outlet 912. At this time, the air flow can enter the chamber inlet 911 of the manifold 9 through the air inlet on the distribution chamber 83, and then be guided from the chamber inlet 911 to the chamber outlet 912. Further, the manifold 9 further includes a ventilation passage (not shown), and the ventilation passage has a ventilation passage outlet and a ventilation passage inlet that communicate with the chamber inlet 911. At this time, the air flow can first enter the ventilation passage inlet of the manifold 9 through the air inlet on the distribution chamber 83, and then enter the chamber inlet 911 through the ventilation passage outlet and be guided to the chamber outlet 912.

[0139] In one embodiment, the third accommodation chamber 82 communicates with the distribution chamber 83. When the manifold 9 is disposed in the distribution chamber 83, the third accommodation chamber 82 realizes communication with the manifold 9. Please refer to Figure 18 , which shows a sectional view of the simulated inhalation device without the manifold installed in one embodiment of the present application. As Figure 18 shown, both the third accommodation chamber 82 and the distribution chamber 83 are formed in the main body portion 81 and are communicated through a through-hole 85. When the manifold 9 is disposed in the distribution chamber 83, the chamber inlet faces the through-hole 85.

[0140] Please continue to refer to Figure 15 and in combination with Figure 14 , as Figure 14 and Figure 15 shown, when the powder measuring rod is inserted into the third accommodation chamber 82, the dose groove of the powder measuring rod faces the through-hole 85 and is opposite to the chamber inlet, so that the air flow entering from the ventilation passage inlet enters the dose groove through the ventilation passage outlet, carries the powder, and reaches the chamber inlet, and then is guided to the chamber outlet.

[0141] In one embodiment, the chamber inlet and the ventilation passage outlet are arranged side by side to generate an air flow channel. When the rod of the powder measuring rod is docked with the simulated inhalation device, the opening of the dose groove faces the air flow channel, so that the air flow passes through the dose groove from the ventilation passage outlet to the chamber inlet, and then is guided from the chamber inlet to the chamber outlet to complete the test operation. When performing an air flow analysis test, the simulated inhalation device is connected to an interface to simulate inhalation, generating a negative pressure in the manifold, so that air enters the simulated inhalation device from the air inlet, is then inhaled from the ventilation passage inlet of the manifold, and passes through the ventilation passage outlet of the manifold. Since the opening of the dose groove of the powder measuring rod faces the ventilation passage outlet and the chamber inlet, the air enters the dose groove at the ventilation passage outlet, carries the powder, forms an air flow with uniform powder particles, and enters the chamber inlet of the manifold, and then leaves from the chamber outlet of the manifold.

[0142] In one embodiment, the third accommodation chamber is used to receive the powder measuring rod. Please refer to Figure 19, which shows a schematic structural view of the simulated inhalation device in another perspective in an embodiment of the present application. As Figure 19 shown, the third accommodation chamber includes a rod receiving chamber 821 for inserting the rod of the powder measuring rod. In one example, the rod receiving chamber 821 is configured as a hole structure that penetrates through the main body 81 in the front and rear directions. When the positioning plate 842 as shown in Figure 14 is installed on the main body 81, it can close the rear part of the hole structure and has a certain positioning effect on the powder measuring rod to a certain extent. It should be noted here that in order to distinguish the rod receiving chamber included in the third accommodation chamber from the rod receiving chambers included in other devices or components, in the embodiment, the rod receiving chamber included in the third accommodation chamber is also referred to as the third rod receiving chamber. When referring to the rod receiving chamber further included in the third accommodation chamber later, it will not be repeated.

[0143] In one embodiment, the third rod receiving chamber 821 has a size that fits snugly with the rod, so that when the third rod receiving chamber 821 is inserted into the third accommodation chamber 82, it closes the dose slot, thereby preventing external air, impurities or moisture from interfering with the powder. This helps to maintain the consistency of the test environment and thus reduces the influence of interference factors on the test results.

[0144] In one embodiment, as Figure 19 shown, on the basis of including the third rod receiving chamber 821, the third accommodation chamber may further include a groove structure 822 formed in the circumferential direction of the third rod receiving chamber 821. The groove structure 822 is used to cooperate with the positioning portion of the powder measuring rod so that the powder measuring rod docks with the third accommodation chamber 82 along the movement track of the groove structure 822.

[0145] In one embodiment, please refer to Figure 20 and combine with Figure 19 , wherein, Figure 20 shows a cross-sectional view of the simulated inhalation device in an embodiment of the present application. As Figure 19 and Figure 20As shown, the slot structure 822 includes a first slot 8221 and a second slot 8222. The first slot 8221 is axially extended and formed on the inner wall of the third receiving cavity 82, that is, extended and formed in the length direction of the third receiving cavity 82; the second slot 8222 communicates with the first slot 8221 and is configured to be continuously extended and formed in the circumferential direction of the third receiving cavity 82 by the first slot 8221, that is, the second slot 8222 extends in the circumferential direction of the third receiving cavity 82 and communicates with the first slot 8221. Wherein, the powder measuring rod is operated to convert the axial movement of the positioning part in the first slot 8221 into circumferential rotation in the second slot 8222 to complete the docking. Specifically, during the docking process, the operator holds the operating section of the powder measuring rod and inserts the rod into the third rod receiving chamber 821. During the insertion process, the positioning part of the powder measuring rod moves linearly in the first slot 8221. To make the opening of the dose slot on the powder measuring rod face the airway outlet and the chamber inlet, the operator needs to hold the operating section and rotate the rod. During this process, the positioning part of the powder measuring rod rotates in the second slot 8222.

[0146] In an embodiment, the third receiving cavity 82 can be configured into two to receive two powder measuring rods. The air flow carries and mixes the powders in the dose slots of the two powder measuring rods and guides them from the chamber inlet to the chamber outlet. In a realization mode, the two third receiving cavities are arranged on both sides of the manifold in a mirror-symmetrical manner to respectively communicate with their corresponding chamber inlets. For the convenience of distinction, the two third receiving cavities are respectively called the third receiving cavity a and the third receiving cavity b; the two powder measuring rods are respectively called the powder measuring rod a and the powder measuring rod b. As Figure 20 shown, two mirror-symmetrical third receiving cavities are arranged on the main body part 81, namely the third receiving cavity a and the third receiving cavity b. The third receiving cavity a is used to receive the powder measuring rod a, and the third receiving cavity b is used to receive the powder measuring rod b. When the manifold 9 is installed in the distribution cavity, it is exactly located in the middle of the third receiving cavity a and the third receiving cavity b. When performing the air flow analysis test, when the air flow flows from the airway inlet of the manifold to the airway outlet, it is evenly divided into two air flows. These two air flows respectively carry the powders in the dose slots of the powder measuring rod a and the powder measuring rod b, and then enter the chamber inlet of the manifold simultaneously for mixing. The mixed air flow is then guided from the chamber inlet to the chamber outlet.

[0147] In order to facilitate the operator to distinguish between the two third accommodating cavities, in one embodiment, an identification structure is provided around the third accommodating cavity, which is used to indicate the types of the two powder measuring rods received by the two third accommodating cavities, so as to indicate the types of the powders accommodated in the dose grooves of the two powder measuring rods. The identification structure includes, but is not limited to, visual identifications such as color identification, number identification, letter identification, or any combination of the above identifications. The ways of configuring the identification structure around the third accommodating cavity include, but are not limited to, pasting, engraving, labeling, laser engraving, and digital display screens. Further, for the convenience of the operator's observation, the identification structure can be configured on the end face of the proximal end of the main body part and directly above a certain third accommodating cavity corresponding to a certain powder measuring rod.

[0148] In the embodiment where the identification structure is configured as a letter identification, the letters corresponding to the letter identification can be used to indicate the types of the received powder measuring rods. When the types of the powders used for analysis and testing are different or when it is necessary to mix the powders in different powder measuring rods during the analysis and testing, the letters can conveniently give visual instructions to the operator. The operator can judge which type of powder measuring rod is received by observing the letters, so as to judge which type of powder is accommodated in the powder measuring rod to avoid confusion. For example, the letter identification A on the end face of the proximal end of the main body part can be used to indicate that the received is the first powder measuring rod, and the dose groove contains a preset amount of the first powder; if the letter identification on the end face of the proximal end of the main body part is B, it is used to indicate that the received is the second powder measuring rod, and the dose groove contains a preset amount of the second powder. The letter identification A and the letter identification B can be arranged side by side.

[0149] When the third accommodating cavity can be configured as two mirror-symmetrical ones for docking with two powder measuring rods, taking the first powder measuring rod inserted into the third accommodating cavity a and the second powder measuring rod inserted into the third accommodating cavity b as an example, where the first powder measuring rod and the second powder measuring rod can be respectively configured as Figures 1 to 6 the powder measuring rods described in any embodiment of Figure 5 and its related descriptions. For example, they can be respectively configured as Figure 21 shown in the first powder measuring rod 1 and the second powder measuring rod 2. Please refer to Figure 20 and in combination with Figure 21 which shows a schematic diagram of the process of docking the simulated inhalation device with the powder measuring rod in one embodiment of the present application. As Figure 21 shown, the operator inserts the first powder measuring rod 1 into its corresponding third accommodating cavity through the letter identification. During the insertion, specifically, the operator holds the operation section of the first powder measuring rod 1 to align the positioning part of the first powder measuring rod 1 with the groove structure of the third accommodating cavity with the letter identification A, so as to insert the first powder measuring rod 1 into the third accommodating cavity with the letter identification A, forming as Figure 21The state shown in a. At this time, the opening direction of the dose slot of the first powder measuring rod 1 is in the vertical direction, and the preset angle between the letter mark A on the proximal end face and the vertical direction of the dose slot is 45°. Then, the operator holds the operation section of the first powder measuring rod 1 and rotates the first powder measuring rod 1 counterclockwise by 45° (as shown by the arrow in Figure 21 b). At this time, the letter mark A on the proximal end face of the first powder measuring rod 1 is in the vertical direction to complete the docking of the first powder measuring rod 1, forming the state shown in Figure 21 b. At this time, the dose slot of the first powder measuring rod 1 faces the air passage outlet of the manifold and the chamber inlet.

[0150] After completing the docking of the first powder measuring rod 1, the operator then needs to complete the docking of the second powder measuring rod 2. In the example shown in Figure 5 , the second powder measuring rod 2 is longer than the first powder measuring rod 1. Therefore, when completing the docking operation shown in Figure 21 , the operator can avoid conflict with the first powder measuring rod 1. Please continue to refer to Figure 21 . The operator inserts the second powder measuring rod 2 into its corresponding third receiving cavity through the letter mark. During the insertion, specifically, the operator first holds the operation section of the second powder measuring rod 2 and aligns the positioning part of the second powder measuring rod with the groove structure of the third receiving cavity of the letter mark B, so as to insert the second powder measuring rod 2 into the third receiving cavity of the letter mark B, forming the state shown in Figure 21 c. At this time, the opening direction of the dose slot of the second powder measuring rod 2 is in the vertical direction, and the preset angle between the letter mark B on the proximal end face and the vertical direction of the dose slot is -45°. Then, the operator holds the operation section of the second powder measuring rod 2 and rotates the second powder measuring rod 2 clockwise by 45° (as shown by the arrow in Figure 21 d) until the letter mark B on the proximal end face of the second powder measuring rod 2 is in the vertical direction to complete the docking of the second powder measuring rod 2, forming the state shown in Figure 21 d. At this time, the dose slot of the second powder measuring rod 2 faces the air passage outlet of the manifold and the chamber inlet.

[0151] After completing the docking of the first powder measuring rod 1 and the second powder measuring rod 2, the operator connects the simulated inhalation device to an interface to simulate the inhalation process, thereby generating negative pressure in the simulated inhalation device, so that air enters from the air inlet, is inhaled from the air passage inlet of the manifold, and passes through the air passage outlet of the manifold, carrying the first powder and the second powder in the dose slots of the first powder measuring rod 1 and the second powder measuring rod 2 respectively, mixing the first powder and the second powder to form an airflow with uniform powder particles, then entering the chamber inlet of the manifold, and finally leaving from the chamber outlet of the manifold.

[0152] The following is combined withFigures 14 to 21 Instructions for the operation of the analytical test using a simulated inhalation device are as follows:

[0153] First, the operator rotates the fixing mechanism 843 to release the first engaging portion, thereby detaching the positioning plate 842 from the main body portion 81. Subsequently, the manifold 9 is inserted into the distribution chamber 83. At this time, the manifold 9 is located at the middle position between the two third accommodation chambers. After the installation of the manifold 9 is completed, the operator rotates the fixing mechanism 843 to make the first engaging portion and the second engaging portion in a clamped state, thereby realizing the installation of the positioning plate 842 on the main body portion 81. Then, the operator holds the operating section of the first powder measuring rod and inserts the rod along the first groove 8221 into the third accommodation chamber with the letter identification A, and then rotates the first powder measuring rod along the second groove 8222 so that its dose groove faces the airway outlet and the chamber inlet of the manifold. Thereafter, the operator holds the operating section of the second powder measuring rod and inserts the rod along the first groove 8221 into the third accommodation chamber with the letter identification B, and then rotates the second powder measuring rod along the second groove 8222 so that its dose groove faces the airway outlet and the chamber inlet of the manifold, waiting for subsequent test operations.

[0154] In some embodiments, the powder measuring system disclosed in the present application may further include a test device and an access device. The test device is used to correspond to the chamber outlet of the simulated inhalation device to complete the test operation. For example, when it is necessary to perform a particle uniformity test on the powder, the test device can be configured as a dose unit sampling device; when it is necessary to perform particle size classification on the powder, the measuring device can be configured as a new generation pharmaceutical impactor.

[0155] The access device is used to configure the simulated inhalation device to transfer the simulated inhalation device to correspond to the test device. In one example, a pin is provided on the access device. Correspondingly, holes are provided on both the left and right side surfaces of the main body portion of the simulated inhalation device, which can cooperate with the pins on the access device, so that the simulated inhalation device can be installed on the access device. Further, the installation height of the access device and the simulated inhalation device is the same as the height of the test device, so that the chamber inlet of the simulated inhalation device can correspond to the test device, thereby enabling the generation of air flow to complete the corresponding air flow analysis test.

[0156] It should be noted here that the above powder measuring system is only an exemplary illustration. In some embodiments, the powder measuring system disclosed in the present application may also include a combination of any of the above rods, components, devices, or equipment. For example, the powder measuring system may include a powder measuring rod, a simulated inhalation device, a test device, and an access device. Among them, for the powder measuring rod, please refer to Figures 1 to 6 the content in any embodiment and its related description, and for the simulated inhalation device, please refer to Figures 14 to 21The content in any embodiment and its related description will not be elaborated here; for the test device and the access device, please refer to the previous description and will not be elaborated here either.

[0157] In summary, for the powder measurement system disclosed in this application, by setting up a powder measurement rod, the accommodation of a preset amount of powder is achieved, thus realizing the accuracy of the test dose; by setting up a powder filling device, the filling of the preset amount of powder in the powder measurement rod is realized, further realizing the accuracy of the test; by setting up a transfer device, the storage and transfer of the powder measurement rod are realized, and the loss and contamination of the powder can be avoided; by setting up a simulated inhalation device, the formation of air flow can be realized, and docking with the powder measurement rod can be completed for drug dispensing; through the coordinated action of the powder measurement rod, the powder filling device, the transfer device, and the simulated inhalation device, the air flow analysis test for an inhaler-type air flow dispensing device can be realized, thus avoiding the consumptive test of using the inhaler itself.

[0158] The above embodiments are only illustrative of the principles and effects of this application and are not used to limit this application. Any person familiar with this technology can modify or change the above embodiments without departing from the spirit and scope of this application. Therefore, all equivalent modifications or changes completed by those with ordinary knowledge in the technical field without departing from the spirit and technical idea disclosed in this application should still be covered by the claims of this application.

Claims

1. A simulated inhalation device, characterized in that: Used to cooperate with the powder measuring rod to distribute the powder, the simulated inhalation device includes: a main body portion on which a manifold is disposed, the manifold having a chamber inlet and a chamber outlet; The accommodating chamber is configured on the main body to receive the powder measuring rod, and is connected to the chamber inlet so that when the powder measuring rod is docked with the accommodating chamber, the dosage groove of the powder measuring rod is connected to the chamber inlet, so that the airflow can carry the powder in the dosage groove from the chamber inlet to the chamber outlet.

2. The simulated inhalation device according to claim 1, characterized in that A distribution chamber for configuring the manifold is disposed on the main body, and the distribution chamber has an air inlet communicated with the chamber inlet for the airflow to enter the manifold.

3. The simulated inhalation device according to claim 2, characterized in that A positioning mechanism for holding the manifold in the distribution chamber is arranged on the air inlet, and an air intake structure corresponding to the air inlet is arranged on the positioning mechanism so that the airflow can enter the air inlet.

4. The simulated inhalation device according to claim 3, characterized in that The air intake structure is configured as a grid opened on the positioning mechanism.

5. The simulated inhalation device according to claim 3, characterized in that: The positioning mechanism comprises a positioning plate, and the positioning plate is detachably shielded on the air inlet through a fixing mechanism.

6. The simulated inhalation device according to claim 5, characterized in that The positioning plate is provided with a first combining portion, the fixing mechanism is connected to the main body and is provided with a second combining portion, and the fixing mechanism is rotated so that the second combining portion engages with or releases the first combining portion.

7. The simulated inhalation device according to claim 6, characterized in that The fixing mechanism includes at least one fixing member, and the fixing member is configured as an eccentric bolt screwed on the main body, and the head of the eccentric bolt is configured as the second connecting portion.

8. The simulated inhalation device according to claim 2, characterized in that The distribution chamber and the accommodating chamber are communicated with each other through a through-hole, and when the manifold is arranged in the distribution chamber, the chamber inlet faces the through-hole.

9. The simulated inhalation device according to claim 8, characterized in that When the powder measuring rod is docked with the accommodating cavity, the dosage groove faces the through-hole and is opposite to the cavity entrance.

10. The simulated inhalation device according to claim 1, characterized in that The accommodating chamber includes a rod receiving chamber, into which the rod of the medicine powder measuring rod is inserted.

11. The simulated inhalation device according to claim 10, characterized in that The rod receiving chamber has dimensions that fit snugly with the rod such that the rod receiving chamber closes the dosage slot when inserted into the receiving cavity.

12. The simulated inhalation device according to claim 10, characterized in that The accommodating cavity further comprises a groove structure formed in the circumference of the rod receiving chamber, and the groove structure is used to cooperate with the positioning portion of the powder measuring rod so that the powder measuring rod can dock with the accommodating cavity in accordance with the movement trajectory of the groove structure.

13. The simulated inhalation device according to claim 12, characterized in that The slot structure comprises: A first groove is formed and axially extends on the inner wall of the accommodating cavity; a second groove, connected to the first groove, and configured to be formed by continuing to extend the first groove in the circumferential direction of the accommodation cavity; The powder measuring rod is operated so that the positioning portion is converted from axial movement in the first groove to circumferential rotation in the second groove to complete the docking.

14. The simulated inhalation device according to claim 1, characterized in that The accommodating chamber is configured to have two to receive two powder measuring rods, and the airflow carries and mixes the powders in the dosage grooves of the two powder measuring rods and is guided from the chamber inlet to the chamber outlet.

15. The simulated inhalation device according to claim 1, characterized in that The two accommodating chambers are arranged on both sides of the manifold in a mirror-symmetrical manner to be connected to the corresponding chamber inlets respectively.

16. The simulated inhalation device according to claim 1, characterized in that An identification structure is arranged around the accommodating cavity to indicate the type of the powder measuring rod received by the accommodating cavity.

17. The simulated inhalation device according to claim 16, characterized in that The identification structure is configured as a letter identification, and the letters corresponding to the letter identification are used to indicate the type of the received powder measuring rod.

18. The simulated inhalation device according to claim 17, characterized in that There are two accommodating cavities, the letter of the letter mark corresponding to the first accommodating cavity is letter A, and the letter of the letter mark corresponding to the second accommodating cavity is letter B.

19. The simulated inhalation device according to claim 1, characterized in that The manifold comprises: a chamber having said chamber inlet and said chamber outlet; The airway has an airway outlet and an airway inlet connected to the chamber inlet. When the powder measuring rod is docked with the accommodating chamber, the opening of the dosage groove faces the airway outlet and the chamber inlet, so that the airflow entering from the airway inlet enters the dosage groove through the airway outlet and carries the powder to the chamber inlet.

20. The simulated inhalation device according to claim 19, characterized in that The chamber inlet and the airway outlet are arranged side by side.

21. A drug powder measuring system, characterized in that: include: A powder measuring rod for containing a preset amount of powder; A simulated inhalation device, used for docking with the powder measuring rod to perform powder dispensing, which is configured as the simulated inhalation device according to any one of claims 1 to 20; A testing device, used to correspond to the chamber outlet of the simulated inhalation device to complete the testing operation; The access device is used to configure the simulated inhalation device to transfer the simulated inhalation device to correspond to the test device.

22. A drug powder measuring system, characterized in that: include: A powder measuring rod for containing a preset amount of powder; a medicine powder filling device, which is used to receive the medicine powder measuring rod to fill the medicine powder into the medicine powder measuring rod; A transfer device, used to receive a powder measuring rod containing powder to store or transfer the powder measuring rod; A simulated inhalation device, used for docking with the powder measuring rod to perform powder dispensing, which is configured as the simulated inhalation device as claimed in any one of claims 1 to 20.

23. The drug powder measuring system according to claim 22, characterized in that: Also includes: A testing device, used to correspond to the chamber outlet of the simulated inhalation device to complete the testing operation; The access device is used to configure the simulated inhalation device to transfer the simulated inhalation device to correspond to the test device.

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