Fluxapyroxad and epoxiconazole degerming agent and preparation method thereof

Abstract

The invention discloses a bactericide containing fluxapyroxad and epoxiconazole, which is prepared from the following raw materials in percentage by weight: 5 to 20 percent of epoxiconazole, 5 to 20 percent of fluxapyroxad, 0.01 to 0.5 percent of defoaming agent and the balance of solvent. The weight ratio of the fluxapyroxad to the epoxiconazole is 1: (1-5), the fluxapyroxad and the epoxiconazole are prepared into the suspension liquid, the prepared pesticide suspension liquid can improve the sterilization and antibacterial capacity of a system and cannot generate cross resistance, and formed pesticide spray is small in particle size and can be used for spraying pesticide. The wetting dispersant adopts the combination of sodium polycarboxylate and alkyl naphthaldehyde condensate, so that the wetting permeability of the liquid medicine can be improved, fog drops are prevented from falling off in the spraying process, the adhesion of the liquid medicine is enhanced, and the deposition amount of the liquid medicine on the surface of a target is increased.

Description

Technical Field

[0001] The present invention relates to the field of pesticides or bactericides, and particularly to a bactericide containing fluxapyroxad and epoxiconazole and a preparation method thereof. Background Art

[0002] Fluxapyroxad and epoxiconazole are common bactericides for grains, fruits and vegetable plants. Using a single agent alone is likely to cause drug resistance, which is not conducive to the sustainable growth and use of crops. The synergistic effect of fluxapyroxad and epoxiconazole can reduce the generation of drug resistance. However, when the two agents act together, the interaction between the technical material and the preparation needs to be considered. Therefore, it is crucial to develop a medicament with good dissolution and permeability and a long residence time on plants.

[0003] Chinese Patent CN113519538A discloses a bactericidal composition preparation and its application, which uses a combination bactericidal preparation of a pyrazole-carboxamide compound and a triazole bactericide, in combination with at least one carrier and an adjuvant, formulated into an emulsifiable concentrate, a water emulsion, a microemulsion, a suspension concentrate, a suspoemulsion, or a dispersible oil suspension concentrate, expanding the control range of various crop diseases and reducing environmental pollution. However, its thermal stability is poor, and the particle size will change significantly after high-temperature storage of the suspension concentrate, affecting the drug efficacy. Chinese Patent CN119014427A discloses the use of β-nicotinamide mononucleotide as a plant growth regulator. Exogenous application of NMN (β-nicotinamide mononucleotide) has a good regulatory effect on crop growth, especially excellent in increasing yield, but it does not have a long-term bactericidal effect. Summary of the Invention

[0004] In order to develop a medicament with good dissolution and permeability and a long residence time on plants, a first aspect of the present invention provides a bactericide containing fluxapyroxad and epoxiconazole. By weight percentage, the raw materials for preparation include at least 5-20% of epoxiconazole, 5-20% of fluxapyroxad, 0.01-0.5% of an antifoaming agent, and the solvent is supplemented to 100%.

[0005] As a preferred embodiment, the dosage form of the bactericide is selected from one of an emulsifiable concentrate, a microemulsion, a suspension concentrate, a water dispersible granule, and a soluble concentrate.

[0006] As a preferred embodiment, the weight ratio of epoxiconazole to fluxapyroxad is 1:(1-5).

[0007] As a preferred embodiment, the weight ratio of epoxiconazole to fluxapyroxad is 1:1.

[0008] During the experiment, the inventor found that preparing a suspension with the combination of fluxapyroxad and epoxiconazole can improve the bactericidal and antibacterial abilities and will not produce cross-resistance. Fluxapyroxad inhibits the respiration of fungi by inhibiting the activity of succinate dehydrogenase in the complex of the mitochondrial respiratory chain, and epoxiconazole achieves the antibacterial effect by inhibiting the activity of C-14 demethylase in biosynthesis, showing a mutually promoting antibacterial effect. Moreover, the structures of fluxapyroxad and epoxiconazole have certain similarities, enabling them to be atomized into smaller atomized droplets for uniform spraying application.

[0009] As a preferred embodiment, by weight percentage, the raw materials for preparing the suspending agent further include 3 - 10% of a wetting dispersant, 1 - 5% of a dispersant, 1 - 8% of antifreeze agent I, 0.1 - 2% of a thickener, and 0.01 - 0.5% of a preservative.

[0010] As a preferred embodiment, by weight percentage, the raw materials for preparing the suspending agent include 7% of a wetting dispersant, 3% of a dispersant, 5% of antifreeze agent I, 0.38% of a thickener, 0.15% of a preservative, and 0.05% of an antifoaming agent.

[0011] As a preferred embodiment, the solvent of the suspending agent is water.

[0012] As a preferred embodiment, by weight percentage, the raw materials for preparing the microemulsion include 20 - 30% of an emulsifying dispersant, 5 - 10% of an emulsifier, 5 - 10% of antifreeze agent II, 10 - 20% of a cosolvent, and 1 - 5% of deionized water.

[0013] As a preferred embodiment, by weight percentage, the raw materials for preparing the microemulsion include 24% of an emulsifying dispersant, 8% of an emulsifier, 8% of antifreeze agent II, 15% of a cosolvent, 0.02% of an antifoaming agent, and 4.78% of deionized water.

[0014] As a preferred embodiment, the solvent of the microemulsion is a combination of ADMA10 and solvent oil 200#. Preferably, the weight ratio of ADMA10 to solvent oil 200# is (3 - 5) : 2.

[0015] As a preferred embodiment, the wetting dispersant includes at least one of polycarboxylate dispersants, sulfonate dispersants, and alkylnaphthalene formaldehyde condensates.

[0016] As a preferred embodiment, the sulfonate dispersant is selected from at least one of sodium naphthalene sulfonate, rosin-based naphthalene sulfonate, alkylaryl naphthalene sulfonate, and naphthalene sulfonate formaldehyde polymer.

[0017] As a preferred embodiment, the wetting dispersant comprises sodium polycarboxylate and alkylnaphthalene formaldehyde condensate. Preferably, the weight ratio of the alkylnaphthalene formaldehyde condensate to the sodium polycarboxylate is (3 - 5):(1 - 3). More preferably, the weight ratio of the alkylnaphthalene formaldehyde condensate to the sodium polycarboxylate is 4:3.

[0018] As a preferred embodiment, the dispersant is a mixture of vegetable oil polyoxyethylene ether and fatty alcohol ether sulfonate.

[0019] As a preferred embodiment, the density of the polycarboxylate dispersant at 25 °C is 1 - 3 kg / m 3 , and the kinematic viscosity at 40 °C is 1250 - 1400 mPa·s.

[0020] As a preferred embodiment, the density of the polycarboxylate dispersant at 25 °C is 1.1 kg / m 3 , and the kinematic viscosity at 40 °C is 1310 mPa·s.

[0021] As a preferred embodiment, the surface tension of the dispersant at 25 °C and 65% condition is 25 - 30 mN / m.

[0022] As a preferred embodiment, the surface tension of the dispersant at 25 °C and 65% condition is 27 mN / m.

[0023] During the experiment, the inventors used a combination of sodium polycarboxylate and alkylnaphthalene formaldehyde condensate as the wetting dispersant, which can improve the wetting and permeability of the liquid medicine, prevent the droplets from bouncing off during spraying, enhance the adhesion of the liquid medicine, and increase the deposition amount of the liquid medicine on the target surface. The possible reasons are speculated as follows: Sodium polycarboxylate is a comb-shaped macromolecular structure dispersant. At a density of 1.1 kg / m 3 , the heterocyclic-containing side chains are easy to adsorb with pesticide molecules. The combination of sodium polycarboxylate and alkylnaphthalene formaldehyde condensate can form an interfacial protective film on the surface of the technical drug particles. The electrostatic repulsion between the drug particles and the steric hindrance of the macromolecular chains maintain the long-term stability of the suspension. And the longer comb-shaped side chains can swing to reduce the resistance between the drug particles and the target, increase the adhesion of the agent, and improve the deposition amount of the liquid medicine on the target surface.

[0024] During the experiment, the inventor found that by introducing a mixture of 3% vegetable oil polyoxyethylene ether and fatty alcohol ether sulfonate as a tank mix adjuvant, the growth of particle size in the heat storage environment was avoided, the viscosity stability of heat storage was improved, the adhesion of the medicament on the plant surface was further enhanced, and the utilization rate of pesticides was increased. The possible reasons are speculated as follows: The critical micelle concentration of the tank mix adjuvant of the mixture of vegetable oil polyoxyethylene ether and fatty alcohol ether sulfonate is relatively low, and its dispersibility after mixing with water is good, which can reduce droplet drift, prevent droplet bounce, increase the deposition amount of the liquid medicine, and its permeability is good, avoiding the evaporation of droplet moisture and improving the rain erosion resistance of the liquid medicine.

[0025] As a preferred embodiment, both the antifreeze I and antifreeze II are selected from at least one of ethylene glycol, propylene glycol, glycerol, urea, n-butanol, and butanediol.

[0026] As a preferred embodiment, the antifreeze I is ethylene glycol; the antifreeze II is n-butanol.

[0027] As a preferred embodiment, the thickener is selected from at least one of magnesium aluminum silicate and xanthan gum.

[0028] As a preferred embodiment, the thickener is a combination of magnesium aluminum silicate and xanthan gum, and the weight ratio of magnesium aluminum silicate to xanthan gum is (0.1 - 0.3):(0.1 - 0.2).

[0029] As a preferred embodiment, the weight ratio of magnesium aluminum silicate to xanthan gum is 0.2:0.18.

[0030] As a preferred embodiment, the defoamer is selected from at least one of silicone defoamers and polyether defoamers.

[0031] As a preferred embodiment, the preservative is an isothiazolinone preservative. Preferably, the preservative is benzisothiazolin-3-one.

[0032] The second aspect of the present invention provides a method for preparing a bactericide of fluxapyroxad and epoxiconazole, comprising the following steps:

[0033] S1 Add the wetting dispersant, preservative, defoamer, and solvent to the mixing kettle according to the ratio, and stir and mix for ≥15 min;

[0034] S2 Premix the antifreeze I and the thickener, and add them to the mixing kettle in step S1, and pre-shear for 1 - 2 h;

[0035] S3 Continuously add epoxiconazole and fluxapyroxad, and shear for 1 - 2 h;

[0036] S4 Transfer the mixture sheared in step S3 into a sand mill to make the particle size D90 < 5 μm;

[0037] S5 After sand grinding in step S4, add a dispersant and continue sand grinding for 20 - 40 min to obtain the product.

[0038] As a preferred embodiment, the preparation method of the bactericide of fluxapyroxad and epoxiconazole includes the following steps:

[0039] S1 Add the antifreeze, cosolvent, and solvent into a preparation kettle, turn on the stirrer, first add fluxapyroxad and stir until completely dissolved, and then add epoxiconazole into the preparation kettle for dissolution and mixing;

[0040] S2 Weigh the emulsifying dispersant and emulsifier accurately according to the feeding ratio and add them into the preparation kettle in sequence, then turn on the stirrer for mixing;

[0041] S3 Add the defoamer into the preparation kettle and stir evenly, then add deionized water into the preparation kettle and mix for 30 - 60 min to obtain the product.

[0042] As a preferred embodiment, the bactericide of fluxapyroxad and epoxiconazole is applied to cereal crops, leguminous vegetables, and tuberous vegetable crops.

[0043] Compared with the prior art, the present invention has the following beneficial effects:

[0044] (1) For the bactericide of fluxapyroxad and epoxiconazole of the present invention, fluxapyroxad and epoxiconazole are in a weight ratio of 1:(1 - 5), and fluxapyroxad and epoxiconazole are prepared into a suspension. The prepared medicament suspension can improve the bactericidal and antibacterial abilities of the system, will not produce cross-resistance, and the particle size of the formed pesticide spray is small, enabling spray application.

[0045] (2) For the bactericide of fluxapyroxad and epoxiconazole of the present invention, the combination of polycarboxylate salt and alkylnaphthalene formaldehyde condensate is used as the wetting dispersant, which can improve the wetting and permeability of the liquid medicine, prevent the droplets from bouncing off during spraying, enhance the adhesion of the liquid medicine, and increase the deposition amount of the liquid medicine on the target surface.

[0046] (3) For the bactericide of fluxapyroxad and epoxiconazole of the present invention, a mixture of 3% vegetable oil polyoxyethylene ether and fatty alcohol ether sulfonate is added as a dispersant, which avoids the increase in particle size under the hot storage environment, improves the viscosity stability of hot storage, further improves the adhesion of the medicament on the plant surface, and improves the utilization rate of the pesticide.

[0047] (4) For the bactericide of fluxapyroxad and epoxiconazole of the present invention, it uses a density of 1.1 kg / m 3, The sodium polycarboxylate with a kinematic viscosity of 1310 mPa·s improves the dispersibility of the bactericide suspension, makes the inclusion of sodium polycarboxylate and the original drug closer, effectively controls the particle size growth, and can achieve stable dispersibility.

[0048] (5) The bactericide of fluxapyroxad and epoxiconazole in the present invention uses fluxapyroxad and epoxiconazole as effective active ingredients. Under the action of specific dispersants and wetting dispersants, the compound combination of the two not only does not produce cross-resistance, but also can effectively improve the bactericidal and antibacterial ability of the preparation. For crops such as cereals, leguminous vegetables, and tuber vegetables, it has both protective and therapeutic effects, inhibits the germination of spore seeds of target fungi, the growth of germ tubes and mycelia, and achieves the bactericidal effect. Description of the Drawings

[0049] Figure 1 Particle size distribution diagram before storage of Example 1;

[0050] Figure 2 Particle size distribution diagram after storage of Example 1;

[0051] Figure 3 Particle size distribution diagram before storage of Comparative Example 1;

[0052] Figure 4 Particle size distribution diagram after storage of Comparative Example 1;

[0053] Figure 5 Particle size distribution diagram before storage of Comparative Example 2;

[0054] Figure 6 Particle size distribution diagram after storage of Comparative Example 2;

[0055] Figure 7 Particle size distribution diagram before storage of Comparative Example 4;

[0056] Figure 8 Particle size distribution diagram after storage of Comparative Example 4;

[0057] Figure 9 Photo of pasting during grinding of Comparative Example 3;

[0058] Figure 10 Photo of wetting and permeability test of Example 1 and Comparative Example 4, left: Comparative Example 4; right: Example 1. Detailed Description of the Invention

[0059] Example 1

[0060] A bactericide of fluxapyroxad and epoxiconazole, calculated by weight percentage, the preparation raw materials include 15% of epoxiconazole, 15% of fluxapyroxad, 0.05% of defoamer, 7% of wetting dispersant, 3% of dispersant, 5% of antifreeze I, 0.38% of thickener, and 0.15% of preservative. The solvent is supplemented to 100%.

[0061] The dosage form of the bactericide is a suspension.

[0062] The solvent is water; the wetting and dispersing agent includes sodium polycarboxylate and alkylnaphthalene formaldehyde condensate, and the weight ratio is 3:4. The density of the sodium polycarboxylate at 25 °C is 1.1 kg / m 3 , and the kinematic viscosity at 40 °C is 1310 mPa·s.

[0063] The sodium polycarboxylate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., and the model is SP-27001. The alkylnaphthalene formaldehyde condensate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., and the model is SP-3219.

[0064] The dispersing agent is a mixture of vegetable oil polyoxyethylene ether and fatty alcohol ether sulfonate. The surface tension at 25 °C and 65% condition is 27 mN / m. It is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., and the model is SP-6535sj.

[0065] The antifreeze I is ethylene glycol.

[0066] The thickening agent is a combination of magnesium aluminum silicate and xanthan gum, and the weight ratio is 0.2:0.18.

[0067] The defoaming agent is an organosilicon defoaming agent, and the model is MOMENTIVE SAG 1572.

[0068] The preservative is benzisothiazolin-3-one, and its purity is 20 wt%.

[0069] A preparation method of a bactericide containing fluxapyroxad and epoxiconazole, comprising the following steps:

[0070] S1 Add the wetting and dispersing agent, preservative, defoaming agent, and solvent to the mixing kettle according to the ratio, and stir and mix for ≥15 min;

[0071] S2 Premix the antifreeze I and the thickening agent, and add them to the mixing kettle in step S1, and pre-shear for 1 h;

[0072] S3 Continue to add epoxiconazole and fluxapyroxad, and shear for 1 h;

[0073] S4 Transfer the mixture sheared in step S3 to a sand mill to make the particle size D90 < 5 μm;

[0074] S5 After sand grinding in step S4, add the dispersing agent and continue sand grinding for 30 min to obtain the product.

[0075] Comparative Example 1

[0076] A bactericide of fluxapyroxad and epoxiconazole and its preparation method. The specific implementation manner is the same as that of Example 1, except that the wetting dispersant includes sodium polycarboxylate and rosin ether modifier, and the weight ratio is 3:4. The sodium polycarboxylate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-27001, and the rosin ether modifier is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-SC3.

[0077] Comparative Example 2

[0078] A bactericide of fluxapyroxad and epoxiconazole and its preparation method. The specific implementation manner is the same as that of Example 1, except that the wetting dispersant includes sodium polycarboxylate, a mixture of rosin-based naphthalene sulfonate polymer dispersant and alkylbenzene sulfonate, and the weight ratio is 3:4. The sodium polycarboxylate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-27001, and the mixture of rosin-based naphthalene sulfonate polymer dispersant and alkylbenzene sulfonate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-SC29.

[0079] Comparative Example 3

[0080] A bactericide of fluxapyroxad and epoxiconazole and its preparation method. The specific implementation manner is the same as that of Example 1, except that the wetting dispersant includes sodium polycarboxylate and polycarboxylate, and the weight ratio is 3:4. The sodium polycarboxylate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-27001, and the polycarboxylate is purchased from Jiangsu Qingyu Chemical Technology Co., Ltd., with the model number SP-3275.

[0081] Comparative Example 4

[0082] A bactericide of fluxapyroxad and epoxiconazole and its preparation method. The specific implementation manner is the same as that of Example 1, except that the addition amount of the dispersant is 0.

[0083] Example 2

[0084] A bactericide of fluxapyroxad and epoxiconazole. By weight percentage, the preparation raw materials include 5.1% of epoxiconazole, 5.1% of fluxapyroxad, 0.02% of defoamer, 24% of emulsifying dispersant, 8% of emulsifier, 8% of antifreeze II, 15% of cosolvent, 4.78% of deionized water, and the solvent is supplemented to 100%.

[0085] The dosage form of the bactericide is microemulsion.

[0086] The defoamer is defoamer 3114, purchased from BASF.

[0087] The emulsifying dispersant is Kaiyuan 5031D, and the emulsifier is EL10.

[0088] The solvent is a combination of ADMA10 and solvent oil 200#, and the weight ratio is 20:10.

[0089] The co-solvent is dimethylacetamide. The antifreeze II is n-butanol.

[0090] A method for preparing a bactericide of fluxapyroxad and epoxiconazole, comprising the following steps:

[0091] S1 Add the antifreeze, co-solvent, and solvent to a preparation kettle, turn on the stirrer, first add fluxapyroxad and stir until completely dissolved, and then add epoxiconazole to the preparation kettle for dissolution and mixing;

[0092] S2 Weigh the emulsifying dispersant and emulsifier accurately according to the feeding ratio and add them to the preparation kettle in sequence, and turn on the stirrer for mixing;

[0093] S3 Add the defoamer to the preparation kettle and stir evenly, and then add deionized water to the preparation kettle and mix for 60 minutes to obtain the product.

[0094] Performance test

[0095] 1. Stability test: After storing the bactericide suspensions of Example 1 and Comparative Examples 1-3 at 54 °C for 14 days, observe the change in the D90 particle size. The test results are shown in Table 1. The particle size distribution before storage of Example 1 is shown in Figure 1 , and the particle size distribution after storage is shown in Figure 2 , the particle size distribution before storage of Comparative Example 1 is shown in Figure 3 , and the particle size distribution after storage is shown in Figure 4 , the particle size distribution before storage of Comparative Example 2 is shown in Figure 5 , and the particle size distribution after storage is shown in Figure 6 , the particle size distribution before storage of Comparative Example 4 is shown in Figure 7 , and the particle size distribution after storage is shown in Figure 8 , and the photos of the pasty state during the grinding process of Comparative Example 3 are shown in Figure 9 .

[0096] Table 1

[0097]

[0098] 2. Wetting and permeability: Add pigments to the bactericides prepared in Example 1 and Comparative Example 4 and place them in a petri dish. Use 2 completely identical wooden strips and place them in the liquid in the petri dish. The liquid heights are the same, and observe the climbing of the wooden strips. The test results are shown in Figure 10 . Left: Comparative Example 4; Right: Example 1. The higher the climbing height of the wooden strip, the better, indicating that the wetting and permeability of the medicament are stronger. The wetting and permeability effect of the medicament in Example 1 is the best.

[0099] 3. Viscosity: Measure the viscosity before stirring in Example 1, and then measure the viscosity using a #2 rotor at a rotational speed of 6 rpm. The viscosity before stirring in Example 1 was 1021 mPa·s, and the viscosity after stirring was 1503 mPa·s. This proves that in the condition of introducing dispersant SP-6535sj in Example 1, the viscosity is relatively high, and the formed suspending agent is not prone to sedimentation.

[0100] 3. Physicochemical property test: Measure the physicochemical properties of the microemulsion bactericide in Example 2 after storage at 0°C for 14 days and at 54°C for 14 days. If no crystals precipitate in the dilution solution after 1 hour, it is recorded as qualified dilution stability.

[0101] Persistent foaming property: Invert the graduated cylinder 180° up and down 30 times (2 s each time) with the middle of the graduated cylinder as the center; after inverting the graduated cylinder 30 times, record the foam volume after standing for 1 min ± 10 s.

[0102] The test results are shown in Table 2.

[0103] Table 2

[0104] Stored at 0°C for 14 days Stored at 54°C for 14 days Dilution stability Qualified Qualified pH 7.66 7.58 <![CDATA[Persistent foaming property / cm 3 > 0 1

[0105] 4. Toxicity test:

[0106] Using acetone as a solvent, prepare stock solutions of the test agents fluxapyroxad technical (A) and epoxiconazole technical (B) at 1×10 4 mg / L respectively, and store them in the refrigerator for later use.

[0107] The effective ingredient ratios of the mixture of the two are fluxapyroxad:epoxiconazole at 3:1, 2:1, 1:1, 1:2, and 1:3 for five formulations, and also prepare stock solutions at 1.0×10 4 mg / L respectively, and store them in the refrigerator for later use.

[0108] Dilute the stock solutions with an aqueous solution containing 0.1 wt% Tween 80. Design 5 concentrations for each treatment. The concentration settings of the two agents and their different formulations are as follows (actual concentration in the culture medium):

[0109] Fluxapyroxad (A): 2.4, 1.2, 0.6, 0.3, 0.15 mg / L

[0110] Epoxiconazole (B): 1, 0.5, 0.25, 0.125, 0.0625 mg / L

[0111] A:B (3:1): 1.8, 0.9, 0.45, 0.225, 0.1125 mg / L

[0112] A:B (2:1): 1.5, 0.75, 0.375, 0.1875, 0.09375 mg / L

[0113] A: B (1:1): 1.3, 0.65, 0.325, 0.1625, 0.08125 mg / L

[0114] A: B (1:2): 1.2, 0.6, 0.3, 0.15, 0.075 mg / L

[0115] A: B (1:3): 1.2, 0.6, 0.3, 0.15, 0.075 mg / L

[0116] An aqueous solution containing 0.1 wt% Tween 80 was used as a control.

[0117] The bacterial strain was the colony growing on the PDA medium plate, with a colony diameter of about 4 - 5 cm and consistent colony growth.

[0118] Referring to the mycelial growth rate method (NY / T 1156.2 - 2006) (petri dish method) specified in the "Guidelines for Indoor Biomonitoring Tests of Pesticides - Bactericides" and the determination of the combined effect of bactericide mixtures.

[0119] Calculate the mycelial growth inhibition rate of each treatment concentration on the test strain, and then use DPS data processing software to calculate the test results, and separately obtain the toxicity regression equations, EC 50 and EC 90 as well as the 95% confidence limits, and calculate the co - toxicity coefficient (CTC) of different ratios of the two agents.

[0120] The test results are shown in Table 3.

[0121] Table 3

[0122]

[0123]

[0124] In the range of the test - designed ratios of 2:1 to 1:1 for fluxapyroxad and epoxiconazole, the co - toxicity coefficients are all greater than 120, showing synergistic effects to varying degrees. Among them, the co - toxicity coefficient of the 1:1 ratio is the largest, with a significant synergistic effect.

Claims

1. A fungicide of fluopyraclostrobin and epoxiconazole, characterized in that: The raw materials for preparation include at least 5-20% of epoxiconazole, 5-20% of fluopyraclostrobin, 0.01-0.5% of defoamer, and the solvent is supplemented to 100%.

2. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 1, characterized in that: The dosage form of the bactericide is selected from a microemulsion and a suspension.

3. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 2, characterized in that: Calculated by weight percentage, the raw materials for preparing the suspension further include 3-10% wetting and dispersing agent, 1-5% dispersing agent, 1-8% antifreeze agent I, 0.1-2% thickener, and 0.01-0.5% preservative.

4. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 2, characterized in that: In terms of weight percentage, the raw materials for preparing the microemulsion also include 20-30% of emulsifying dispersant, 5-10% of emulsifier, 5-10% of antifreeze agent II, 10-20% of cosolvent and 1-5% of deionized water.

5. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 3, characterized in that: The wetting dispersant includes at least one of a polycarboxylate dispersant, a sulfonate dispersant, and an alkylnaphthalene formaldehyde condensate.

6. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 5, characterized in that: The density of the polycarboxylate dispersant at 25°C is 1-3 kg / m 3 , the kinematic viscosity at 40°C is 1250-1400mPa·s.

7. The fungicide of trifloxystrobin and epoxiconazole according to claim 3, characterized in that: The surface tension of the dispersant under the conditions of 25° C. and 65% is 25-30 mN / m.

8. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 3, characterized in that: The antifreeze agent I is selected from at least one of ethylene glycol, propylene glycol, glycerol, urea, n-butanol and butanediol.

9. The fungicide of fluopyraclostrobin and epoxiconazole according to claim 3, characterized in that: The thickener is selected from at least one of magnesium aluminum silicate and xanthan gum.

10. A method for preparing the fungicide of fluopyraclostrobin and epoxiconazole according to any one of claims 5 to 9, characterized in that: The following steps are involved: S1 Add the wetting dispersant, preservative, defoamer and water into the preparation kettle according to the proportion, and stir and mix for ≥15 minutes; S2: pre-mix the antifreeze agent I and the thickener, add them into the preparation kettle of step S1, and pre-shear for 1-2 hours; S3 continues to add fluopicolide and fluopicolide, and shears for 1-2h; S4: transferring the mixture sheared in step S3 into a sand mill to make the particle size D90 less than 5 μm; S5: adding a dispersant after sand milling in step S4, and continuing sand milling for 20-40 minutes to obtain the product.

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