Nutritional composition capable of promoting growth and development and application thereof

Abstract

The invention provides a nutritional composition capable of promoting growth and development and application thereof. The invention provides a composition for the first time, and the composition comprises hydrolyzed protein, medium chain triglyceride (MCT) and 1, 3-dioleic acid 2-palmitic acid triglyceride (OPO structure lipid). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product for promoting growth and development.

Description

Technical Field

[0001] The present invention belongs to the technical field of nutritional compositions, and particularly relates to a nutritional composition capable of promoting growth and development and related applications. Background Art

[0002] The birth weight of a newborn is an important indicator to measure the health of the newborn. A number of data show that the birth weight is closely related to the health after birth. The birth weight of premature / low birth weight infants is less than 2500 g, and their organ functions and adaptability are worse than those of full-term infants or normal weight infants. They are a group that requires special attention. In terms of growth and development, weight gain, immunity, organ development, digestion and absorption, etc. are mainly concerned.

[0003] Reasonable nutritional support is one of the key links to improve the survival rate of premature / low birth weight infants, which is not only related to recent growth and disease outcome, but also directly affects long-term prognosis. Sufficient and balanced nutrition is the material basis for ensuring the healthy growth of premature / low birth weight infants.

[0004] Currently, in the fields of premature / low birth weight infant formula, infant formula, complementary foods and nutritional supplements, etc., solutions for promoting growth and development are needed. Summary of the Invention

[0005] One object of the present invention is to provide a composition capable of promoting growth and development.

[0006] Another object of the present invention is to provide a product containing the composition, such as food.

[0007] Another object of the present invention is to provide related applications of the composition or food in promoting growth and development.

[0008] On the one hand, the present invention provides a composition, which includes: hydrolyzed protein, medium-chain triglyceride (MCT), and 1,3-dioleoyl-2-palmitoyl glycerol (OPO structured lipid).

[0009] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of hydrolyzed protein, MCT to OPO structured lipid is (0.1 - 3.6):(0.1 - 3):1.

[0010] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of hydrolyzed protein, MCT to OPO structured lipid is (0.1 - 3.2):(0.1 - 3):1.

[0011] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of hydrolyzed protein, MCT to OPO structured lipid is (0.2 - 3.2):(0.2 - 3):1.

[0012] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of hydrolyzed protein, MCT and OPO structured lipid is (0.2 - 3.0):(0.2 - 2.8):1.

[0013] According to the specific embodiments of the present invention, in the composition of the present invention, the hydrolyzed protein is hydrolyzed milk protein or hydrolyzed whey protein. Specifically, the hydrolyzed protein in the present invention refers to proteins and polypeptide fragments with a molecular weight less than 10,000 Da. The raw material for providing the hydrolyzed protein of the present invention can be hydrolyzed milk protein powder or hydrolyzed whey protein powder. Preferably, the content of proteins and polypeptide fragments with a molecular weight less than 10,000 Da in such raw material powder is not less than 30%, preferably not less than 40%.

[0014] According to the specific embodiments of the present invention, in the composition of the present invention, the MCT is medium-chain fatty acids with a carbon chain length of 8 - 12. The source of the MCT of the present invention can be coconut oil, palm oil, MCT oil, and other edible oils that can provide MCT.

[0015] According to the specific embodiments of the present invention, in the composition of the present invention, the OPO can be provided by edible oil or fat powder rich in 1,3-dioleoyl-2-palmitoyl glycerol. Generally, when the raw material providing OPO is directly added to the composition, the content of 1,3-dioleoyl-2-palmitoyl glycerol is preferably not less than 40%.

[0016] According to the specific embodiments of the present invention, the composition of the present invention is a nutritional composition or a food composition. Specifically, in the nutritional composition or food composition, in addition to the hydrolyzed protein, MCT and OPO, other components can also be included, such as one or more of other proteins, other oils and fats, carbohydrates, vitamins, minerals, etc. In some specific embodiments of the present invention, the hydrolyzed protein (i.e., proteins and polypeptides with a molecular weight less than 10,000 Da) accounts for 10% - 100% of the total protein content in the composition; preferably 10% - 80%, more preferably 10% - 60%. In some specific embodiments of the present invention, MCT accounts for 1% - 40% of the total fat content in the composition. In some specific embodiments of the present invention, the content of OPO structured lipid accounts for 1% - 10% of the final product.

[0017] In some specific embodiments of the present invention, the food of the present invention is milk powder, which can be prepared by adding hydrolyzed protein, MCT and OPO to a basic formula powder. Among them, after the milk powder of the present invention is prepared, the contents of hydrolyzed protein, MCT and OPO can be determined by conventional methods in the art, such as high performance liquid chromatography detection and analysis techniques. There is no particular limitation on the basic formula powder in the present invention, as long as it is a commonly used milk powder formula in the art. For example, the basic formula powder can be an ordinary infant formula or a toddler formula. As an example, the basic formula powder of the present invention can use milk powder of animal origin as the main raw material, and can further be added with whey powder, vitamins, minerals, etc. As the milk powder of animal origin, cow milk powder or goat milk powder can be used.

[0018] On the other hand, the present invention also provides the application of the described composition in the preparation of a product for promoting growth and development.

[0019] In some specific embodiments of the present invention, the product is food.

[0020] In some specific embodiments of the present invention, the product is an infant formula food, a formula food for infants and young children, or an infant formula food for special medical purposes.

[0021] On the other hand, the present invention also provides a food, which comprises the composition described in the present invention.

[0022] According to the specific embodiments of the present invention, in the food of the present invention, the hydrolyzed protein accounts for 10%-100% of the total protein content in the food; preferably 10%-80%, more preferably 10%-60%.

[0023] According to the specific embodiments of the present invention, in the food of the present invention, MCT accounts for 1%-40% of the total fat content in the food.

[0024] According to the specific embodiments of the present invention, in the food of the present invention, the proportion of OPO structured lipid in the final food product is 1%-10%.

[0025] In some specific embodiments of the present invention, the food is an infant formula food, a formula food for infants and young children, or an infant formula food for special medical purposes.

[0026] On the other hand, the present invention also provides the application of the described food in the preparation of a product for promoting growth and development.

[0027] According to the specific embodiments of the present invention, in the present invention, the promotion of growth and development includes promoting the weight and / or organ development of infants and young children.

[0028] In some specific embodiments of the present invention, the infants and young children are premature and / or low birth weight infants and young children.

[0029] In some specific embodiments of the present invention, the promotion of growth and development includes promoting the increase in body weight, heart weight, spleen weight, small intestine weight, and / or small intestine length. According to the specific embodiments of the present invention, the composition of the present invention is a protein composition.

[0030] The composition of the present invention containing hydrolyzed protein, MCT, and OPO can promote the growth and development of premature and / or low-birth-weight infants and is beneficial to their healthy growth. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 Showing the initial body weights and final body weights of experimental animals in different groups in specific embodiments of the present invention.

[0032] Figure 2 Showing the average daily weight gains of experimental animals in different groups in specific embodiments of the present invention.

[0033] Figure 3 Showing the milk weight ratios of experimental animals in different groups in specific embodiments of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0034] Before further describing the specific embodiments of the present invention, it should be understood that the protection scope of the present invention is not limited to the following specific embodiments; it should also be understood that the terms used in the embodiments of the present invention are for describing specific embodiments and not for limiting the protection scope of the present invention.

[0035] When the embodiments give a numerical range, it should be understood that unless otherwise specified in the present invention, both endpoints of each numerical range and any value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as commonly understood by those skilled in the art of the present technology. In addition to the specific methods, devices, and materials used in the embodiments, according to the knowledge of those skilled in the art of the present technology and the description of the present invention, any methods, devices, and materials of the prior art similar or equivalent to those described in the embodiments of the present invention can also be used to implement the present invention.

[0036] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt the conventional techniques in the art of the present technology.

[0037] In the embodiments, the raw material of the hydrolyzed protein used is hydrolyzed whey protein powder, and the protein and polypeptide fragments with a molecular weight less than 10,000 Da are not less than 40%. In the embodiments, the amount of the hydrolyzed protein is calculated based on the amount of the protein and polypeptide fragments with a molecular weight less than 10,000 Da.

[0038] In the examples, the source of the MCT used was commercially available conventional MCT oil, and its main components were medium-chain fatty acids with a carbon chain length of 8-12.

[0039] In the examples, the OPO used was commercially available conventional OPO.

[0040] Efficacy experiment of the nutritional composition in promoting growth and development

[0041] 1 Experimental animals and grouping

[0042] Three-day-old low-birth-weight piglets (BW = 1.05 - 1.25 kg) were selected for the experiment. According to the principle of similar average body weight, the piglets were randomly divided into 6 groups, and each group was fed with the formula for 7 days to observe the weight gain of the piglets. One day before the end of the experiment, the piglets were fasted for 10 h, weighed on an empty stomach, anesthetized, bled to death. After blood collection, all piglets were dissected according to the conventional method, and the heart, liver, and kidneys were separated and weighed respectively. The entire intestine was taken out, and the duodenum, jejunum, and ileum of the entire small intestine were separated for length measurement and weighing.

[0043] The food fed to each group was formed by adding or not adding one or more of hydrolyzed protein, OPO structured lipid, and MCT to the basic powder (piglet powder). The specific composition of the formula is shown in Table 1.

[0044] Table 1

[0045]

[0046] Note: Vitamins and minerals were added according to regulatory requirements, and the contents were the same in the examples and the comparative examples.

[0047] 2 Experimental results

[0048] 1) Feeding situation of piglets in different groups

[0049] The weight changes of low-weight piglets in different groups were tracked during the feeding period to evaluate the effects of different nutritional compositions on the weight gain of piglets ( Figure 1 ). The results showed that the groups added with the hydrolyzed protein + OPO + MCT nutritional composition in Examples 1-3 had better weight gain effects compared with Comparative Examples 1-3. It was shown that adding only one or two nutritional compositions, such as OPO, or hydrolyzed protein + MCT, could not achieve a weight gain effect similar to that of the nutritional composition added with hydrolyzed protein + OPO + MCT.

[0050] The average daily gain of piglets in different groups was analyzed, and the results were similar to the weight gain situation ( Figure 2)。Compared with Comparative Examples 1-3, the average daily weight gain of Examples 1-3 was significantly increased. The experimental results showed that the addition of the hydrolyzed protein + MCT + OPO nutritional composition in Examples 1-3 had an effect of promoting the weight gain of piglets compared with Comparative Example 1 (without the addition of hydrolyzed protein + MCT + OPO), Comparative Example 2 (only adding OPO), or Comparative Example 3 (adding hydrolyzed protein + MCT). Adding only one or two nutritional compositions, such as OPO, or hydrolyzed protein + MCT, could not achieve an effect similar to that of the nutritional composition adding hydrolyzed protein + MCT + OPO in promoting weight gain.

[0051] The milk weight ratio refers to the ratio of the weight of milk powder consumed to increase 1 kg of body weight, which can reflect the utilization efficiency of nutrients in the milk powder. The lower the milk weight ratio, the less milk powder is required to increase 1 kg of body weight, and the higher the utilization efficiency of nutrients in the milk powder. Compared with Comparative Example 1, Examples 1-3 had a significantly lower milk weight ratio ( Figure 3 ), indicating that adding the hydrolyzed protein + OPO + MCT nutritional composition could significantly improve the utilization efficiency of nutrients in the milk powder. Taking Example 1 as an example, only 1.66 kg of the formula powder of Example 1 was consumed to increase 1 kg of body weight. In contrast, 3.32 kg of the formula powder of Comparative Example 1 was required.

[0052] The organ index of the experimental animals is one of the main biological characteristic indicators, and the size of the organs can also indicate the strength of their functions to a certain extent. Compared with the comparative examples, the examples had significant advantages in promoting the weight and length of the heart, spleen, and small intestine, etc. (Table 2). The results showed that the nutritional composition of the present invention not only had advantages in promoting growth catch-up, but also had advantages in promoting the organ development of special infant populations.

[0053] Table 2. Effects of different formulas on organ development

[0054] Organ Comparative Example 1 Comparative Example 2 Comparative Example 3 Heart (g) 8.0±0.38b 8.4±0.33b 8.62±0.43b Spleen (g) 2.56±0.31b 2.66±0.28ab 2.82±0.32ab Small intestine weight (g) 71.8±1.63b 72.04±4.22b 82.38±4.88a Small intestine length (cm) 334.6±16.98b 373.6±22.1ab 402.2±5.92a Organ Example 1 Example 2 Example 3 Heart (g) 9.9±0.58a 9.4±0.51a 10.1±0.44a Spleen (g) 3.2±0.15a 3.08±0.29a 3.0±0.22a Small intestine weight (g) 89.65±4.55a 84.56±4.52a 84.2±3.77a Small intestine length (cm) 396.2±13.55a 390.5±5.01a 389.3±14.29a

[0055] The above description of the embodiments is for the convenience of those of ordinary skill in the art to understand and use the invention. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative labor. Therefore, the present invention is not limited to the above embodiments, and the improvements and modifications made by those skilled in the art without departing from the scope of the present invention should be within the protection scope of the present invention.

Claims

1. A composition, which comprises: hydrolyzed protein, medium-chain triglycerides (MCT), and 1,3-dioleoyl-2-palmitoyl glycerol (OPO structured lipid).

2. The composition according to claim 1, wherein the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is (0.1 - 3.6):(0.1 - 3):1; preferably, the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is (0.1 - 3.2):(0.1 - 3):1; preferably, the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is (0.2 - 3.2):(0.2 - 3):1; more preferably, the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is (0.2 - 3.0):(0.2 - 2.8):

1.

3. The composition according to claim 1 or 2, wherein: the hydrolyzed protein is hydrolyzed milk protein or hydrolyzed whey protein.

4. The composition according to any one of claims 1 - 3, which is a nutritional composition or a food composition.

5. Use of the composition according to any one of claims 1 - 3 in the preparation of a product for promoting growth and development; preferably, the product is a food.

6. A food, which comprises the composition according to any one of claims 1 - 3.

7. The food according to claim 6, wherein the hydrolyzed protein accounts for 10% - 100% of the total protein content; preferably 10% - 80%, more preferably 10% - 60%; MCT accounts for 1% - 40% of the total fat content in the food; the content of OPO structured lipid accounts for 1% - 10% of the final product.

8. The food according to claim 6, which is the food is milk powder or liquid milk; preferably, the food is infant formula, toddler formula, or infant formula for special medical purposes.

9. Use of the food according to any one of claims 6 - 8 in the preparation of a product for promoting growth and development.

10. The use according to claim 5 or 9, wherein the promoting of growth and development includes promoting the weight and / or organ development of infants and young children; preferably, the infants and young children are premature and / or low birth weight infants and young children; preferably, the promoting of growth and development includes promoting the increase in weight, heart weight, spleen weight, small intestine weight, and / or small intestine length.

Images