Inflammation diminishing and pain relieving plaster for traumatic injury and preparation method thereof

Abstract

The invention discloses a swelling and pain relieving plaster for traumatic injury. The swelling and pain relieving plaster comprises an ointment and a medicinal plaster matrix, the ointment contains a traumatic rheumatism fluid extract; the traumatic rheumatism fluid extract is prepared from the following raw materials: flos carthami, radix aucklandiae, rhizoma nardostachyos, radix aconiti kusnezoffii, dragon's blood, radix aconiti kusnezoffii, rhizoma seu radix notopterygii, rhizoma corydalis, rhizoma kaempferiae, frankincense, myrrh, rhizoma sparganii, rhizoma atractylodis macrocephalae, flos caryophylli, radix angelicae sinensis, native copper, radix clematidis and raw semen strychni. According to the plaster for relieving swelling and pain after traumatic injury, volatile oil in the medicine is extracted by adopting a supercritical CO2 extraction technology in the preparation process, so that the extraction rate of the volatile oil is increased, and the damage to effective components is reduced; the volatile medicine inclusion compound is prepared by adopting an inclusion technology, so that the loss of volatile active ingredients in the preparation and storage processes of the musk traumatic injury ointment is reduced, the curative effect of the medicine is improved, and the musk traumatic injury ointment has a better curative effect on rheumatism, swelling and pain and arthralgia.

Description

Technical Field

[0001] The present invention relates to a plaster, and in particular to an anti-inflammatory and pain-relieving plaster for traumatic injuries and its preparation method. Background Art

[0002] Volatile oils (VO), also known as essential oils, are a general term for a class of oily liquids that exist in plants, are volatile, can be distilled with steam, and are immiscible with water. Volatile oils have the characteristics of strong lipophilicity and low boiling point. In the current preparation methods of anti-swelling and pain-relieving plasters for traumatic injuries on the market, the main method for extracting volatile oils is solvent extraction. Common solvents used in solvent extraction are petroleum ether, ether, carbon tetrachloride, etc. Herbs such as Notopterygium incisum, Sanguis draxonis, Olibanum, Myrrha, Angelica sinensis, and Kaempferia galanga are usually extracted by heating under reflux with 90% ethanol. Since 90% ethanol has a large polarity, it cannot fully extract the volatile oils in Notopterygium incisum, Sanguis draxonis, Olibanum, Myrrha, Angelica sinensis, and Kaempferia galanga. At the same time, the extraction process has a high temperature and a long extraction time, which is likely to cause damage to heat-unstable and easily oxidized components, and is not conducive to the exertion of the drug's efficacy. In the current preparation methods of anti-swelling and pain-relieving plasters for traumatic injuries on the market, the volatile oils are directly mixed with the matrix material to form a coating, and then the plaster is applied, cut into sections, lined, cut into pieces, which is likely to cause loss of volatile components and reduce the drug's efficacy. Traditional rubber agents are made into pulp with gasoline, which is not conducive to environmental protection, and it is painful to tear off after use and is prone to allergic reactions, resulting in poor medication compliance of patients. Summary of the Invention

[0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide an anti-swelling and pain-relieving plaster for traumatic injuries and its preparation method.

[0004] To achieve the above purpose, the technical solution adopted by the present invention is: an anti-swelling and pain-relieving plaster, comprising a medicinal paste and a medicinal plaster matrix; the medicinal paste comprises a rheumatism and trauma fluid extract; the preparation raw materials of the rheumatism and trauma fluid extract comprise the following components: Flos Carthami, Radix Aucklandiae, Radix Nardostachyos, Aconitum kusnezoffii Reichb., Sanguis draxonis, Aconitum carmichaelii Debx., Notopterygium incisum, Rhizoma Corydalis, Kaempferia galanga, Olibanum, Myrrha, Rhizoma Sparganii, Rhizoma Curcumae, Flos Caryophylli, Angelica sinensis, Pyritum, Clematis chinensis Osbeck, and Strychnos nux-vomica L.

[0005] The preparation method of the rheumatism and trauma fluid extract comprises the following steps:

[0006] (1), Weigh Notopterygium incisum, Sanguis draxonis, Olibanum, Myrrha, Angelica sinensis, and Kaempferia galanga, place them in a supercritical extraction device, and perform 2 supercritical extraction to obtain extract A and medicinal residue B;

[0007] (2) Weigh safflower, costus root, nard, kusnezoff monkshood root, sichuan aconite root, rhizoma corydalis, rhizoma sparganii, zedoary, clove, pyrite, clematis root and semen strychni, pulverize them, mix with residue B of medicine, then add 80-90% ethanol solution and heat under reflux for extraction to obtain an extract, concentrate the extract to obtain a thick paste C with a relative density of 1.2-1.25 at 80 °C;

[0008] (3) Mix extract A and thick paste C evenly to obtain the tincture of traumatic injury and rheumatism;

[0009] In the swelling-relieving and pain-killing plaster of the present invention, the extraction of the tincture of traumatic injury and rheumatism adopts supercritical CO 2 extraction method, and supercritical CO 2 extraction technology is used to extract the volatile oils from notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root. Compared with the existing technology of heating under reflux with 90% ethanol for extraction, the extraction rate of the volatile oils is significantly improved, realizing the extraction of volatile oil components at low temperature, reducing the damage to heat-unstable and easily oxidized components, the extraction solvent can be recycled and there is no solvent residue in the extract, with lower energy consumption and more environmental protection. The residue B obtained after supercritical extraction is further extracted with ethanol under reflux together with drugs such as safflower, costus root, nard, kusnezoff monkshood root, sichuan aconite root, rhizoma corydalis, rhizoma sparganii, zedoary, clove, pyrite, clematis root and semen strychni to further extract the volatile oils from notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root. The relative density of the thick paste C being 1.2-1.25 means the relative density to water is 1.2-1.25, and in the present invention, the relative density all refers to the relative density to water.

[0010] Preferably, the conditions for the CO 2 supercritical extraction are: extraction pressure is 20-30 MPa, extraction temperature is 40-50 °C, decompression pressure is 5-7 MPa, decompression temperature is 30-50 °C, and extraction time is 2.5-3.5 hours.

[0011] When the volatile oils in notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root are under the above-mentioned CO 2 supercritical extraction conditions, the recovery rate of the volatile oils in notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root is above 4.1%.

[0012] Preferably, the conditions for the CO 2 supercritical extraction are: extraction pressure is 28 MPa, extraction temperature is 42 °C, decompression pressure is 6 MPa, decompression temperature is 42 °C, and extraction time is 3 hours.

[0013] When the volatile oils in notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root are under the above-mentioned CO 2 supercritical extraction conditions, the recovery rate of the volatile oils in notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root can reach 4.2%.

[0014] Preferably, the weight ratio of safflower, costus root, nardostachyos root and rhizome, kusnezoff monkshood root, dragon's blood, sichuan aconite root, incised notopterygium root, rhizoma corydalis, kaempferia galanga, frankincense, myrrh, rhizoma sparganii, zedoary, clove, Chinese angelica, pyrite, clematis root and semen strychni is: safflower∶costus root∶nardostachyos root and rhizome∶kusnezoff monkshood root∶dragon's blood∶sichuan aconite root∶incised notopterygium root∶rhizoma corydalis∶kaempferia galanga∶frankincense∶myrrh∶rhizoma sparganii∶zedoary∶clove∶Chinese angelica∶pyrite∶clematis root∶semen strychni = 0.8 - 1.2∶3.8 - 4.2∶5.8 - 6.2∶1.8 - 2.2∶3.8 - 4.2∶1.8 - 2.2∶5.8 - 6.2∶3.8 - 4.2∶5.8 - 6.2∶1.8 - 2.2∶3.8 - 4.2∶1.8 - 2.2∶3.8 - 4.2∶1.8 - 2.2∶5.8 - 6.2∶3.8 - 4.2∶5.8 - 6.2∶1.8 - 2.2;

[0015] Safflower has the effects of promoting blood circulation to remove blood stasis, dispelling dampness and reducing swelling; costus root has the effects of promoting qi circulation to relieve pain and strengthening the stomach for digestion; nardostachyos root and rhizome has the effects of dispelling dampness and reducing swelling, promoting qi circulation to relieve pain and waking up the spleen by removing stasis; kusnezoff monkshood root has the effects of dispelling wind and dampness, warming the channels and dispersing cold, reducing swelling and relieving pain; dragon's blood has the effects of activating blood circulation to relieve pain, removing stasis to stop bleeding and promoting granulation for sore healing; sichuan aconite root has the effects of dispelling wind and dampness, warming the channels and relieving pain; incised notopterygium root has the effects of inducing sweating to dispel cold, dispelling wind and dampness, and relieving pain; rhizoma corydalis has the effects of activating blood circulation, promoting qi circulation and relieving pain; kaempferia galanga has the functions of dispelling cold, removing dampness, warming the spleen and stomach, and expelling foul qi; frankincense has the effects of promoting blood circulation to relieve pain, dredging the channels, reducing swelling and promoting granulation; myrrh has the effects of reducing swelling and promoting granulation, regulating qi to relieve pain, and activating blood circulation to remove stasis; rhizoma sparganii has the effects of promoting blood circulation by breaking blood stasis and relieving pain; zedoary has the effects of activating blood circulation to break stasis and removing stasis to relieve pain; clove has the effects of warming yang and tonifying the kidney, harmonizing the middle and descending adverse qi, and dispelling cold and relieving pain; Chinese angelica has the effects of enriching blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relaxing bowel movements; pyrite has the effects of promoting blood circulation to remove blood stasis, dispersing stasis and relieving pain, and accelerating fracture healing; clematis root has the effects of dispelling wind and dampness, dredging collaterals to relieve pain, and removing fishbone stuck in the throat; semen strychni has the effects of dredging collaterals to relieve pain, dissipating binds and reducing swelling. By using the above drug compatibility, the swelling - relieving and pain - relieving plaster of the present invention can exert the effects of reducing swelling and relieving pain and expelling wind and dampness.

[0016] Preferably, the ointment contains the following components in parts by weight: 280 - 320 parts of traumatic rheumatism fluid extract, 500 - 550 parts of inclusion compound of volatile drugs, 280 - 320 parts of belladonna fluid extract, 110 - 130 parts of camphor and 0.35 - 0.45 parts of artificial musk;

[0017] Among them, the inclusion compound of volatile drugs contains volatile drugs, and the volatile drugs contain the following components: borneol, peppermint oil, ocimum gratissimum oil, cassia oil and methyl salicylate; the weight ratio of borneol, peppermint oil, ocimum gratissimum oil, cassia oil and methyl salicylate is: borneol∶peppermint oil∶ocimum gratissimum oil∶cassia oil∶methyl salicylate = 6∶6∶1∶2∶10.

[0018] Borneol is volatile and has anti-inflammatory and analgesic effects; peppermint oil is a volatile oil and has effects such as spasmolysis, anti-inflammatory analgesia, and promoting penetration; clove basil oil is a volatile oil and contains no less than 80.0% of trans-anethole (C 10 H 12 O), and has analgesic effects; cinnamon oil is a volatile oil and contains no less than 75.0% of cinnamaldehyde (C 9 H 8 O), and has effects such as anti-inflammatory, anti-allergic, and dispelling wind and dampness and relieving pain; methyl salicylate is volatile, can promote local blood circulation, and external use or local application can produce stimulating reactions such as skin vasodilation and red skin color, and reflexively affect the skin, muscles, nerves, and joints of the corresponding parts, playing the roles of detumescence, anti-inflammation, and analgesia. The drugs are formulated according to the above weight ratio, which can increase the curative effect of the detumescence and analgesia plaster.

[0019] Preferably, the preparation method of the clathrate of the volatile drug comprises the following steps:

[0020] (a) Weigh the volatile drug according to the formula, mix the volatile drug with ethanol to obtain an ethanol solution of the volatile substance, weigh β-cyclodextrin, and the mass ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:5-7. Prepare β-cyclodextrin into a supersaturated solution to obtain a supersaturated solution of β-cyclodextrin;

[0021] (b) Add the ethanol solution of the volatile substance to the supersaturated solution of β-cyclodextrin at 40-70°C at a speed of 3-5 mL / min, stir for 2-4 h, the rotation speed is 600-1000 r / min, and continue to stir for 4-6 h after stopping the addition of liquid to obtain a mixed solution of the volatile drug;

[0022] (c) Place the mixed solution of the volatile drug obtained in step (b) in an environment of 2-5°C and freeze for 12-24 h, and filter to obtain a filter residue;

[0023] (d) Dry the filter residue at 30-50°C to obtain the clathrate of the volatile drug.

[0024] The use of volatile drugs in the detumescence and analgesia plaster may cause the plaster to volatilize during the preparation and storage processes, thereby reducing the curative effect. By adopting the clathration technology to clathrate the above 5 volatile drugs, namely borneol, peppermint oil, clove basil oil, cinnamon oil, and methyl salicylate, the loss of volatile active ingredients during the preparation and storage of the plaster can be reduced, and the drug curative effect can be improved.

[0025] When the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is less than 1:7, there is less volatile drug in the volatile drug inclusion complex per unit mass, the inclusion is thicker, and it is more difficult to exert the effect of the volatile drug; when the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is greater than 1:5, the volatile drug cannot be completely included by β-cyclodextrin, and the inclusion effect is poor. Therefore, when the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:5 - 7, the volatile drug can be preferably included in β-cyclodextrin, and the volatile drug inclusion complex per unit mass can exert a better effect.

[0026] Preferably, the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:6.

[0027] Through repeated experiments by the inventor, when the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:6, the volatile drug can be fully included in β-cyclodextrin and can fully exert the effect of the volatile drug.

[0028] Preferably, the medicinal plaster matrix comprises the following components in parts by weight: 1400 - 1600 parts of rubber, 0 - 100 parts of lithopone, 180 - 200 parts of zinc oxide, 900 - 1100 parts of rosin, 2650 - 2800 parts of liquid paraffin, and 240 - 320 parts of vaseline.

[0029] Preferably, the preparation method of the medicinal plaster matrix is as follows:

[0030] (i) Cut and crush the rubber, soak it in gasoline until the rubber swells sufficiently to obtain A;

[0031] (ii) Heat and dissolve the rosin to obtain B;

[0032] (iii) Mix A, B, lithopone, zinc oxide, liquid paraffin and vaseline together and stir evenly to obtain the plaster matrix.

[0033] The present invention also provides a preparation method of the above-mentioned detumescence and pain-relieving plaster. The preparation method of the detumescence and pain-relieving plaster is as follows: Weigh belladonna liquid extract according to the component content, concentrate it to obtain a thick paste of belladonna with a relative density of 1.2 - 1.3 at 65 - 70 °C; then add the thick paste of belladonna, antirheumatic and traumatic liquid extract, inclusion complex of volatile drug, styrax, camphor and artificial musk to the medicinal plaster matrix, mix evenly and coat it on a non-woven fabric material, and dry it to obtain the detumescence and pain-relieving plaster.

[0034] The beneficial effect of the present invention is that: The present invention provides a detumescence and pain-relieving plaster and its preparation method. In the preparation process of the detumescence and pain-relieving plaster of the present invention, supercritical CO 2The extraction technology extracts volatile oils from drugs, improves the extraction rate of volatile oils, and reduces the destruction of active ingredients; the inclusion technology is used to prepare inclusion compounds of volatile drugs, reducing the loss of volatile active ingredients during the preparation and storage of Shexiang Dieda Fengshi Plaster, improving the curative effect of the drug, and having a good curative effect on rheumatism, swelling and pain, and joint pain. Detailed implementation mode

[0035] To better illustrate the purpose, technical solution and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0036] Example 1

[0037] The ointment contains the following components in parts by weight: 320 parts of Dieda Fengshi Extract, 550 parts of inclusion compound of volatile drug, 320 parts of Belladonna Extract, 130 parts of camphor and 0.45 part of artificial musk;

[0038] The Dieda Fengshi Extract contains the following components: the weight ratio of safflower, costus root, nardostachys root, kusnezoff monkshood root, dragon's blood, sichuan aconite root, notopterygium root, rhizoma corydalis, kaempferia root, frankincense, myrrh, rhizoma sparganii, rhizoma zedoariae, clove, angelica root, pyrite, clematis root and strychnos nux-vomica seed is: safflower∶costus root∶nardostachys root∶kusnezoff monkshood root∶dragon's blood∶sichuan aconite root∶notopterygium root∶rhizoma corydalis∶kaempferia root∶frankincense∶myrrh∶rhizoma sparganii∶rhizoma zedoariae∶clove∶angelica root∶pyrite∶clematis root∶strychnos nux-vomica seed = 1.2∶4.2∶6.2∶2.2∶4.2∶2.2∶6.2∶4.2∶6.2∶2.2∶4.2∶2.2∶4.2∶2.2∶6.2∶4.2∶6.2∶2.2;

[0039] The inclusion compound of volatile drug contains volatile drug, and the volatile drug contains the following components: borneol, peppermint oil, clove basil oil, cinnamon oil and methyl salicylate; the weight ratio of borneol, peppermint oil, clove basil oil, cinnamon oil and methyl salicylate is: borneol∶peppermint oil∶clove basil oil∶cinnamon oil∶methyl salicylate = 6∶6∶1∶2∶10;

[0040] The medicinal plaster matrix contains the following components in parts by weight: 1400 parts of rubber, 180 - 200 parts of zinc oxide, 900 parts of rosin, 2650 parts of liquid paraffin and 240 parts of vaseline.

[0041] The preparation method of the Dieda Fengshi Extract in this example includes the following steps:

[0042] (1), Weigh notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia root with a moisture content of less than 5% according to the formula, crush them to 40 - 50 meshes, place them in a supercritical extraction device, and perform CO 2 supercritical extraction to obtain extract A and medicinal residue B;

[0043] (2) Weigh safflower, costus root, nard, kusnezoff monkshood root, sichuan aconite root, Corydalis yanhusuo, rhizoma sparganii, zedoary, clove, pyritum, clematis root and semen strychni, pulverize them, mix with residue B of medicine, then add 80 - 90% ethanol solution and heat under reflux for extraction to obtain an extract, and concentrate the extract to obtain a thick paste C with a relative density of 1.2 - 1.25 at 80°C;

[0044] (3) Mix extract A and thick paste C evenly to obtain the tincture of traumatic injury and rheumatism;

[0045] The preparation method of the inclusion complex of the volatile drug in this example includes the following steps:

[0046] (a) Weigh the volatile drug according to the formula, mix the volatile drug with ethanol to obtain an ethanol solution of the volatile substance, weigh β - cyclodextrin, and the mass ratio of the total mass of the volatile drug to the mass of β - cyclodextrin is 1:5 - 7. Prepare β - cyclodextrin into a supersaturated solution to obtain a supersaturated solution of β - cyclodextrin;

[0047] (b) Add the ethanol solution of the volatile substance to the supersaturated solution of β - cyclodextrin at 40 - 70°C at a speed of 3 - 5 mL / min, stir for 2 - 4 h, with a rotation speed of 600 - 1000 r / min. After stopping the addition of liquid, continue to stir for 4 - 6 h to obtain a mixed solution of the volatile drug;

[0048] (c) Place the mixed solution of the volatile drug obtained in step (b) in an environment of 2 - 5°C and freeze for 12 - 24 h, then filter to obtain a filter residue;

[0049] (d) Dry the filter residue at 30 - 50°C to obtain the inclusion complex of the volatile drug.

[0050] The preparation method of the medicinal plaster matrix in this example is as follows:

[0051] (i) Cut and crush rubber, soak it in gasoline until the rubber swells fully to obtain A;

[0052] (ii) Heat and dissolve rosin to obtain B;

[0053] (iii) Mix A, B, lithopone, zinc oxide, liquid paraffin and vaseline together and stir evenly to obtain the plaster matrix.

[0054] The preparation method of the detumescence and pain - relieving plaster in this example is as follows: Weigh belladonna tincture according to the component content, concentrate it to obtain a thick paste of belladonna with a relative density of 1.2 - 1.3 at 65 - 70°C; then add the thick paste of belladonna, the tincture of traumatic injury and rheumatism, the inclusion complex of the volatile drug, styrax, camphor and artificial musk to the medicinal plaster matrix, mix evenly and coat on a non - woven fabric material, and dry to obtain the detumescence and pain - relieving plaster.

[0055] Example 2

[0056] An embodiment of the detumescence and pain-relieving plaster of the present invention comprises an ointment and a medicinal plaster matrix;

[0057] The ointment comprises the following components in parts by weight: 280 parts of antelope and rheumatism fluid extract, 500 parts of inclusion compound of volatile drugs, 280 parts of belladonna fluid extract, 110 parts of camphor, and 0.35 part of artificial musk;

[0058] The antelope and rheumatism fluid extract comprises the following components: the weight ratio of safflower, costus root, nardostachys root, kusnezoff monkshood root, dragon's blood, sichuan aconite root, notopterygium root, rhizoma corydalis, kaempferia root, frankincense, myrrh, rhizoma sparganii, zedoary, clove, angelica root, pyrite, clematis root, and semen strychni is: safflower∶costus root∶nardostachys root∶kusnezoff monkshood root∶dragon's blood∶sichuan aconite root∶notopterygium root∶rhizoma corydalis∶kaempferia root∶frankincense∶myrrh∶rhizoma sparganii∶zedoary∶clove∶angelica root∶pyrite∶clematis root∶semen strychni∶=0.8∶3.8∶5.8∶1.8∶3.8∶1.8∶5.8∶3.8∶5.8∶1.8∶3.8∶1.8∶3.8∶1.8∶5.8∶3.8∶5.8∶1.8;

[0059] The inclusion compound of volatile drugs comprises volatile drugs, and the volatile drugs comprise the following components: borneol, peppermint oil, eugenol basil oil, cinnamon oil, and methyl salicylate; the weight ratio of borneol, peppermint oil, eugenol basil oil, cinnamon oil, and methyl salicylate is: borneol∶peppermint oil∶eugenol basil oil∶cinnamon oil∶methyl salicylate=6∶6∶1∶2∶10;

[0060] The medicinal plaster matrix comprises the following components in parts by weight: 1600 parts of rubber, 100 parts of lithopone, 1200 parts of zinc oxide, 1100 parts of rosin, 2800 parts of liquid paraffin, and 320 parts of vaseline.

[0061] The preparation method of the antelope and rheumatism fluid extract in this embodiment comprises the following steps:

[0062] (1), Weigh notopterygium root, dragon's blood, frankincense, myrrh, angelica root, and kaempferia root with the moisture content of the medicinal materials less than 5% according to the formula, crush them to 40-50 meshes, and perform CO 2 supercritical extraction, and the extraction conditions are: the extraction pressure is 30 MPa, the extraction temperature is 50 °C, the analysis pressure is 7 MPa, the analysis temperature is 50 °C, and the extraction time is 2.5 hours to obtain extract A and medicinal residue B;

[0063] (2), Weigh safflower, costus root, nardostachys root, kusnezoff monkshood root, sichuan aconite root, rhizoma corydalis, rhizoma sparganii, zedoary, clove, pyrite, clematis root, and semen strychni, crush them, mix them with medicinal residue B, and then heat and reflux extract with 80-90% ethanol solution to obtain an extract, and concentrate the extract to obtain a thick paste C with a relative density of 1.2-1.25 at 80 °C;

[0064] (3) Mix the extract A and the thick extract C evenly to obtain the rheumatic and traumatic topical liquid extract.

[0065] The preparation method of the inclusion complex of the volatile drug in this example includes the following steps:

[0066] (a) Weigh the volatile drug according to the formula, mix the volatile drug with ethanol to obtain an ethanol solution of the volatile substance, weigh β-cyclodextrin, and the mass ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:5. Prepare β-cyclodextrin into a supersaturated solution to obtain a supersaturated solution of β-cyclodextrin.

[0067] (b) Add the ethanol solution of the volatile substance to the supersaturated solution of β-cyclodextrin at 40 °C at a speed of 3 - 5 mL / min, stir for 2 - 4 h, the rotation speed is 600 - 1000 r / min, and continue to stir for 4 - 6 h after stopping the liquid addition to obtain a mixed liquid of the volatile drug.

[0068] (c) Place the mixed liquid of the volatile drug obtained in step (b) in a 5 °C environment and freeze for 24 h, then filter to obtain a filter residue.

[0069] (d) Dry the filter residue at 50 °C to obtain the inclusion complex of the volatile drug.

[0050] The preparation method of the medicinal plaster matrix in this example is as follows:

[0051] (i) Cut and crush the rubber, soak it in gasoline until the rubber swells fully to obtain A.

[0052] (ii) Heat and dissolve the rosin to obtain B.

[0053] (iii) Mix A, B, lithopone, zinc oxide, liquid paraffin and petrolatum together and stir evenly to obtain the plaster matrix.

[0074] The preparation method of the detumescence and pain-relieving plaster in this example is as follows: Weigh the belladonna topical liquid extract according to the component content, concentrate it to obtain a thick extract of belladonna with a relative density of 1.2 - 1.3 at 65 - 70 °C; then add the thick extract of belladonna, the rheumatic and traumatic topical liquid extract, the inclusion complex of the volatile drug, styrax, camphor and artificial musk to the medicinal plaster matrix, mix evenly and coat it on a non-woven fabric material, and dry to obtain the detumescence and pain-relieving plaster.

[0075] Example 3

[0076] An example of the detumescence and pain-relieving plaster described in the present invention includes an ointment and a medicinal plaster matrix.

[0077] The ointment contains the following components in parts by weight: 300 parts of Dieda Fengshi Liujingao, 500 parts of inclusion compound of volatile drugs, 300 parts of Belladonna Liujingao, 225 parts of Liquidambar formosana Hance resin, 120 parts of camphor, and 0.4 part of artificial musk;

[0078] The Dieda Fengshi Liujingao contains the following components: the weight ratio of safflower, costus root, Nardostachys jatamansi DC., kusnezoff monkshood root, dragon's blood, sichuan aconite root, notopterygium root, Corydalis yanhusuo W. T. Wang, Kaempferia galanga L., frankincense, myrrh, rhizoma sparganii, zedoary, clove, Chinese angelica, pyrite, clematis root, and semen strychni is: safflower∶costus root∶Nardostachys jatamansi DC.∶kusnezoff monkshood root∶dragon's blood∶sichuan aconite root∶notopterygium root∶Corydalis yanhusuo W. T. Wang∶Kaempferia galanga L.∶frankincense∶myrrh∶rhizoma sparganii∶zedoary∶clove∶Chinese angelica∶pyrite∶clematis root∶semen strychni∶=1∶4∶6∶2∶4∶2∶6∶4∶6∶2∶4∶6∶2∶4∶2∶6∶4∶6∶2;

[0079] The inclusion compound of volatile drugs contains volatile drugs, and the volatile drugs contain the following components: borneol, peppermint oil, clove basil oil, cinnamon oil, and methyl salicylate; the weight ratio of borneol, peppermint oil, clove basil oil, cinnamon oil, and methyl salicylate is: borneol∶peppermint oil∶clove basil oil∶cinnamon oil∶methyl salicylate=6∶6∶1∶2∶10;

[0080] The medicinal plaster matrix contains the following components in parts by weight: 1500 parts of rubber, 50 parts of lithopone, 190 parts of zinc oxide, 1000 parts of rosin, 2700 parts of liquid paraffin, and 300 parts of petrolatum.

[0081] The preparation method of the Dieda Fengshi Liujingao in this example includes the following steps:

[0082] (1), Weigh notopterygium root, dragon's blood, frankincense, myrrh, Chinese angelica, and Kaempferia galanga L. with the moisture content of the medicinal materials less than 5% according to the formula, crush them to 40-50 meshes, and carry out CO 2 supercritical extraction, and the extraction conditions are: the extraction pressure is 28 MPa, the extraction temperature is 42 °C, the resolution pressure is 6 MPa, the resolution temperature is 42 °C, and the extraction time is 3 hours to obtain extract A and medicinal residue B;

[0083] (2), Weigh safflower, costus root, Nardostachys jatamansi DC., kusnezoff monkshood root, sichuan aconite root, Corydalis yanhusuo W. T. Wang, rhizoma sparganii, zedoary, clove, pyrite, clematis root, and semen strychni, crush them, mix them with medicinal residue B, and then add an 80-90% ethanol solution for heating and reflux extraction to obtain an extract, and concentrate the extract to obtain a thick paste C with a relative density of 1.2-1.25 at 80 °C;

[0084] (3), Mix extract A and thick paste C evenly to obtain Dieda Fengshi Liujingao;

[0085] The preparation method of the inclusion compound of volatile drugs in this example includes the following steps:

[0086] (a), Weigh the volatile drug according to the formula, mix the volatile drug with ethanol to obtain an ethanol solution of the volatile substance, weigh β-cyclodextrin, and the mass ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:6. Prepare β-cyclodextrin into a supersaturated solution to obtain a supersaturated solution of β-cyclodextrin;

[0087] (b), Add the ethanol solution of the volatile substance to the supersaturated solution of β-cyclodextrin at 50 °C at a speed of 3 - 5 mL / min, stir for 3 h, the rotation speed is 800 r / min, and continue to stir for 5 h after stopping the liquid addition to obtain a mixed liquid of the volatile drug;

[0088] (c), Place the mixed liquid of the volatile drug obtained in step (b) in a 4 °C environment and freeze for 18 h, then filter to obtain the filter residue;

[0089] (d), Dry the filter residue at 40 °C to obtain an inclusion compound of the volatile drug.

[0090] The preparation method of the medicinal plaster matrix in this example is as follows:

[0091] (i), Cut and crush the rubber, soak it in gasoline until the rubber swells fully to obtain A;

[0092] (ii), Heat and dissolve rosin to obtain B;

[0093] (iii), Mix A, B, lithopone, zinc oxide, liquid paraffin and vaseline together and stir evenly to obtain the plaster matrix.

[0094] The preparation method of the detumescence and pain-relieving plaster in this example is as follows: Weigh belladonna liquid extract according to the component content, concentrate it to obtain a thick paste of belladonna with a relative density of 1.2 - 1.3 at 65 - 70 °C; then add the thick paste of belladonna, the tincture of traumatic rheumatism, the inclusion compound of the volatile drug, styrax, camphor and artificial musk to the medicinal plaster matrix, mix evenly and coat it on a non-woven fabric material, and dry it to obtain the detumescence and pain-relieving plaster.

[0095] Example 4

[0096] An example of the detumescence and pain-relieving plaster described in the present invention. The components of the ointment and the medicinal plaster matrix in this example are the same as those in Example 3.

[0097] The difference in the preparation method of the tincture of traumatic rheumatism in this example from that in Example 3 lies only in the difference in the conditions of 2 supercritical extraction. The difference is that the extraction conditions in this example are: the extraction pressure is 26 MPa, the extraction temperature is 45 °C, the analytical pressure is 6 MPa, the analytical temperature is 42 °C, and the extraction time is 3 hours;

[0098] The preparation methods of the inclusion compound of the volatile drug, the medicinal plaster base and the swelling-reducing and analgesic plaster described in this example are the same as those in Example 3.

[0099] Example 5

[0100] An embodiment of the swelling-relieving and analgesic patch of the present invention, the ingredients of the ointment and the medicinal patch base in the swelling-relieving and analgesic patch of this embodiment are the same as those in Example 3.

[0101] The preparation method of the inclusion complex of the volatile drug in this embodiment is different from that in Example 3 only in the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin. In this embodiment, the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:5.

[0102] The preparation methods of the traumatic rheumatism fluid extract, the medicinal plaster base and the swelling-reducing and analgesic plaster described in this embodiment are the same as those in Example 3.

[0103] Example 6

[0104] An embodiment of the swelling-relieving and analgesic patch of the present invention, the ingredients of the ointment and the medicinal patch base in the swelling-relieving and analgesic patch of this embodiment are the same as those in Example 3.

[0105] The preparation method of the inclusion complex of the volatile drug in this embodiment is different from that in Example 3 only in the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin. In this embodiment, the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:7.

[0106] The preparation methods of the traumatic rheumatism fluid extract, the medicinal plaster base and the swelling-reducing and analgesic plaster described in this embodiment are the same as those in Example 3.

[0107] Comparative Example 1

[0108] The ingredients of the ointment and the medicinal plaster base in the swelling and pain relief plaster described in this comparative example are the same as those in Example 3.

[0109] The preparation method of the traumatic rheumatism fluid extract described in this comparative example is different from that in Example 3 only in that CO 2 The conditions of supercritical extraction are different, except that the extraction conditions in this comparative example are: extraction pressure of 18 MPa, extraction temperature of 35°C, decomposition pressure of 6 MPa, decomposition temperature of 42°C, and extraction time of 2 hours;

[0110] The preparation methods of the inclusion compound of the volatile drug, the medicinal plaster base and the swelling-reducing and analgesic plaster in this comparative example are the same as those in Example 3.

[0111] Comparative Example 2

[0112] The ingredients of the ointment and the medicinal plaster base in the swelling and pain relief plaster described in this comparative example are the same as those in Example 3.

[0113] The preparation method of the traumatic rheumatism fluid extract described in this comparative example is different from that in Example 3 only in that CO 2 The conditions of supercritical extraction are different, except that the extraction conditions in this comparative example are: extraction pressure of 33 MPa, extraction temperature of 53°C, decomposition pressure of 6 MPa, decomposition temperature of 42°C, and extraction time of 2 hours;

[0114] The preparation methods of the inclusion compound of the volatile drug, the medicinal plaster base and the swelling-reducing and analgesic plaster in this comparative example are the same as those in Example 3.

[0115] Comparative Example 3

[0116] The ingredients of the ointment and the medicinal plaster base in the swelling and pain relief plaster described in this comparative example are the same as those in Example 3.

[0117] The preparation method of the traumatic rheumatism fluid extract described in this comparative example comprises the following steps:

[0118] (1) According to the formula, weigh the medicinal materials with a water content of less than 5% including Notopterygium wilfordii, Sanguisorba officinalis, frankincense, myrrh, angelica sinensis and Kaempferia galanga, grind them into 40-50 meshes, and CO 2 Supercritical extraction, the extraction conditions are: extraction pressure of 28MPa, extraction temperature of 42°C, decomposition pressure of 6MPa, decomposition temperature of 42°C, extraction time of 3 hours, to obtain extract A and residue B;

[0119] (2) weighing safflower, costusroot, nardostachys grandiflora, raw aconite, raw chuanwu, corydalis, trillium, scutellaria baicalensis, clove, natural copper, clematis and raw strychnos nux vomica, grinding them, mixing them with the residue B, then adding 80-90% ethanol solution and heating under reflux to obtain an extract, and concentrating the extract to obtain a thick paste C having a relative density of 1.2-1.25 at 80° C.;

[0120] (3) Mix the extract A and the thick paste C evenly to obtain the fluid extract for traumatic rheumatism;

[0121] The preparation methods of the inclusion compound of the volatile drug, the medicinal plaster base and the swelling-reducing and analgesic plaster in this comparative example are the same as those in Example 3.

[0122] Comparative Example 4

[0123] The ingredients of the ointment and the medicinal plaster base in the swelling and pain relief plaster described in this comparative example are the same as those in Example 3.

[0124] The preparation method of the inclusion complex of the volatile drug in this comparative example is different from that in Example 3 only in that the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is different. In this comparative example, the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:8.

[0125] The preparation methods of the medicated tincture for traumatic injury and rheumatism, the medicinal plaster matrix, and the detumescence and pain-relieving plaster in this comparative example are the same as those in Example 3.

[0126] Comparative Example 5

[0127] The components of the ointment and the medicinal plaster matrix in the detumescence and pain-relieving plaster in this comparative example are the same as those in Example 3.

[0128] The preparation method of the inclusion complex of the volatile drug in this comparative example is different from that in Example 3 only in that the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is different. In this comparative example, the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:4.

[0129] The preparation methods of the medicated tincture for traumatic injury and rheumatism, the medicinal plaster matrix, and the detumescence and pain-relieving plaster in this comparative example are the same as those in Example 3.

[0130] Comparative Example 6

[0131] The difference in the components of the ointment in the detumescence and pain-relieving plaster in this comparative example from those in Example 3 is only in the inclusion complex of the volatile drug. In this comparative example, borneol, menthol oil, clove basil oil, cinnamon oil, and methyl salicylate, the five volatile drugs, are directly used. In this comparative example, the traditional rubber matrix is used instead of the medicinal plaster matrix.

[0132] The preparation method of the medicated tincture for traumatic injury and rheumatism in this comparative example is as follows: Weigh safflower, costus root, nardostachys root, kusnezoff monkshood root, sichuan aconite root, rhizoma corydalis, rhizoma sparganii, zedoary, clove, pyrite, clematis root, and semen strychni according to the formula, crush them into coarse powder, extract twice by heating under reflux with 90% ethanol. The first extraction time is 4 hours, and the second extraction time is 2 hours. Combine the extraction solutions obtained from the first extraction and the second extraction, filter, recover ethanol, and concentrate the combined extraction solution to an extract with a relative density of 1.05 - 1.15 at 20 - 30 °C, thus obtaining the medicated tincture for traumatic injury and rheumatism in this comparative example.

[0133] The preparation method of the detumescence and pain-relieving plaster in this comparative example is as follows: Weigh belladonna tincture according to the component content, concentrate it to obtain a thick paste of belladonna with a relative density of 1.2 - 1.3 at 65 - 70 °C; then add the thick paste of belladonna, the medicated tincture for traumatic injury and rheumatism, the volatile drug, camphor, and artificial musk to the rubber matrix, mix evenly, coat it on a non-woven fabric material, and dry it to obtain the detumescence and pain-relieving plaster in this comparative example.

[0134] Example 7

[0135] The yields of volatile oils in Notopterygii Rhizoma, Sanguis Draxonis, Olibanum, Myrrha, Angelicae Sinensis Radix and Kaempferiae Rhizoma in Examples 1-4 and Comparative Examples 1, 2 and 6 are shown in Table 1.

[0136] Table 1 Yields of volatile oils in Notopterygii Rhizoma, Sanguis Draxonis, Olibanum, Myrrha, Angelicae Sinensis Radix and Kaempferiae Rhizoma in Examples 1-4 and Comparative Examples 1, 2 and 6

[0137]

[0138] As can be seen from Table 1, compared with Comparative Example 6 that completely uses the solvent extraction method, under the conditions of supercritical extraction of CO 2 of the present invention, the yields of volatile oils in Schizonepeta tenuifolia Briq., Kaempferiae Rhizoma and Zingiberis Rhizoma Recens have been significantly improved.

[0139] Example 8

[0140] The anti-swelling and pain-relieving plaster described in Examples 1-6 and Comparative Examples 1-6 was used for the hot plate experiment on mice. The specific experimental method is as follows:

[0141] Take SPF-grade Kunming mice, female. Under the room temperature condition of 22°C, turn on the hot plate analgesia tester, set the temperature to (55±0.5)°C, preheat for 10 min, and then put 1 mouse each time. Use a stopwatch to record the time from the mouse being put in until the pain response (licking the hind paw, kicking the hind leg or jumping) appears. Measure 2 times in total, with an interval of 5 min each time, and calculate the average value (the average value not exceeding 30 s is qualified).

[0142] Screen 120 qualified mice, 10 in each group, and randomly divide them into 12 groups, namely groups A, B, C, D, E, F, a, b, c, d, e, f. Depilate the abdomen 24 h before administration. Each mouse in groups A, B, C, D, E, F was respectively given the anti-swelling and pain-relieving plaster described in Examples 1-6 (for example, the mouse in group A was given the anti-swelling and pain-relieving plaster described in Example 1, the mouse in group B was given the anti-swelling and pain-relieving plaster described in Example 2, and so on), and applied externally; each mouse in groups a, b, c, d, e, f was given the anti-swelling and pain-relieving plaster described in Comparative Examples 1-6 (for example, the mouse in group a was given the anti-swelling and pain-relieving plaster described in Comparative Example 1, the mouse in group b was given the anti-swelling and pain-relieving plaster described in Comparative Example 2, and so on), and applied externally; measure the pain response time 2 times at 60, 90, 120, and 180 min after administration, and calculate the average value. If the mouse still has no pain response in the instrument after 60 s, stop the test, immediately take out the mouse, calculate according to 60 s, and calculate the percentage increase in pain threshold according to the average pain threshold measured at different times after the experiment. The results of the hot plate experiment are shown in Table 2.

[0143] Among them, the percentage increase in pain threshold = (average pain threshold after administration - average pain threshold before administration) / average pain threshold before administration × 100%.

[0144] Table 2 Results of the hot plate experiment

[0145]

[0146]

[0147] Note: * indicates significant difference compared with group f (P < 0.05).

[0148] From the above results of the hot plate experiment, it can be seen that the analgesic effects of the detumescence and pain-relieving plaster described in Examples 1-6 and Comparative Examples 1-6 of the present invention all appeared 60 minutes after administration. Compared with group f (using the detumescence and pain-relieving plaster described in Comparative Example 6), groups A, B, C, D, E, and F (using the detumescence and pain-relieving plaster described in Examples 1-6) had significant differences at 180 minutes (P < 0.05), indicating that the analgesic effect of the detumescence and pain-relieving plaster described in the present invention is significant.

[0149] Example 9

[0150] The detumescence and pain-relieving plaster described in Examples 1-6 and Comparative Examples 1-6 was used to conduct an experiment on auricular swelling in mice caused by xylene. The specific experimental method is as follows:

[0151] 120 SPF-grade Kunming white mice, 60 males and 60 females, 10 in each group, were randomly divided into 12 groups according to body weight, namely groups A, B, C, D, E, F, a, b, c, d, e, and f. The abdominal hair was removed 24 hours before administration. Each mouse in groups A, B, C, D, E, and F was respectively given the detumescence and pain-relieving plaster described in Examples 1-6 (for example, the mouse in group A was given the detumescence and pain-relieving plaster described in Example 1, the mouse in group B was given the detumescence and pain-relieving plaster described in Example 2, and so on), and applied externally; each mouse in groups a, b, c, d, e, and f was given the detumescence and pain-relieving plaster described in Comparative Examples 1-6 (for example, the mouse in group a was given the detumescence and pain-relieving plaster described in Comparative Example 1, the mouse in group b was given the detumescence and pain-relieving plaster described in Comparative Example 2, and so on), and applied externally; 12 hours before the experiment, the mice were fasted and allowed free access to water. 60 minutes after the last administration, xylene was applied to both sides of the right ear of the mice, 50 μl per mouse. 30 minutes later, the mice were sacrificed by cervical dislocation, and both ears were cut along the auricular baseline. Round ear pieces were punched at the same position with a 9 mm puncher, and were precisely weighed with an electronic balance respectively to calculate the swelling inhibition rate. The experimental results are shown in Table 3. Among them, the swelling degree = the weight of the right ear piece - the weight of the left ear piece.

[0152] Table 3 Results of the experiment on auricular swelling caused by xylene

[0154] Group Swelling degree (mg) A 4.06±1.12* B 4.01±1.15* C 3.85±1.52* D 3.67±2.01* E 3.71±1.83* F 4.09±1.03* a 5.76±2.61 b 5.91±3.24 c 6.01±3.52 d 6.58±3.65 e 5.97±1.91 f 6.75±3.54

[0155] Note: * indicates significant difference compared with group f (P < 0.05). From the results of the above table, it can be seen that the detumescence and pain-relieving plaster described in the present invention can significantly inhibit the ear swelling of mice caused by xylene. Compared with group f (using the detumescence and pain-relieving plaster described in Comparative Example 6), groups A, B, C, D, E, and F (using the detumescence and pain-relieving plasters described in Examples 1 to 6) have significant differences at 180 min (P < 0.05), indicating that the detumescence and pain-relieving plaster described in the present invention has an obvious detumescence effect.

[0156] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A swelling-reducing and analgesic plaster for traumatic injuries, characterized in that: The invention comprises an ointment and a medicinal plaster matrix; the ointment comprises the following components in parts by weight: 280-320 parts of traumatic rheumatism fluid extract, 500-550 parts of inclusion compounds of volatile drugs, 280-320 parts of belladonna fluid extract, 110-130 parts of camphor and 0.35-0.45 parts of artificial musk; The raw materials for preparing the traumatic rheumatism fluid extract are composed of the following components: safflower, costusroot, rhizoma nardostachys, raw aconite, blood closter, raw aconite, notopterygium wilfordii, rhizoma corydalis, kaempferia galanga, frankincense, myrrh, trillium, scutellaria baicalensis, clove, angelica sinensis, natural copper, clematis root and raw strychnos nux vomica; the weight ratio of safflower, costusroot, rhizoma nardostachys, raw aconite, blood closter, raw aconite, notopterygium wilfordii, rhizoma corydalis, kaempferia galanga, frankincense, myrrh, trillium, scutellaria baicalensis, clove, angelica sinensis, natural copper, clematis root and raw strychnos nux vomica is: safflower: costusroot: rhizoma nardostachys: raw aconite: blood closter: raw aconite: notopterygium wilfordii: rhizoma corydalis: kaempferia wilfordii ∶Frankincense∶Myrrh∶Trigonum eryngii∶Clove∶Angelica sinensis∶Natural copper∶Clematis chinensis∶Strychnos nux vomica∶=0.8~1.2∶3.8~4.2∶5.8~6.2∶1.8~2.2∶3.8~4.2∶1.8~2.2∶5.8~6.2∶3.8~4.2∶5.8~6.2∶1.8~2.2∶3.8~4.2∶1.8~2.2∶3.8~4.2∶1.8~2.2∶5.8~6.2∶3.8~4.2∶5.8~6.2∶1.8~2.2; The preparation method of the traumatic rheumatism fluid extract comprises the following steps: (1) Weighing notopterygium root, dragon's blood, frankincense, myrrh, angelica root and kaempferia galanga, placing them in a supercritical extraction device, and performing CO2 supercritical extraction to obtain an extract A and a residue B; the conditions of the CO2 supercritical extraction are: an extraction pressure of 20 to 30 MPa, an extraction temperature of 40 to 50° C., a decomposition pressure of 5 to 7 MPa, a decomposition temperature of 30 to 50° C., and an extraction time of 2.5 to 3.5 hours; (2) weighing safflower, costusroot, nardostachys grandiflora, raw aconite, raw chuanwu, corydalis, trillium, scutellaria baicalensis, clove, natural copper, clematis and raw strychnos nux vomica, grinding them, mixing them with the residue B, then adding 80-90% ethanol solution and heating under reflux to obtain an extract, and concentrating the extract to obtain a thick paste C having a relative density of 1.2-1.25 at 80° C.; (3) Mix the extract A and the thick paste C evenly to obtain the fluid extract for traumatic rheumatism; The inclusion compound of the volatile drug contains the volatile drug, and the volatile drug contains the following components: borneol, peppermint oil, clove basil oil, cinnamon oil and methyl salicylate; the weight ratio of the borneol, peppermint oil, clove basil oil, cinnamon oil and methyl salicylate is: borneol: peppermint oil: clove basil oil: cinnamon oil: methyl salicylate = 6: 6: 1: 2: 10; the preparation method of the inclusion compound of the volatile drug comprises the following steps: (a), weighing a volatile drug according to a formula, mixing the volatile drug with ethanol to obtain an ethanol solution of a volatile substance, weighing β-cyclodextrin, wherein the ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:5-7; preparing a supersaturated solution of β-cyclodextrin to obtain a supersaturated solution of β-cyclodextrin; (b), adding the ethanol solution of the volatile substance to the supersaturated β-cyclodextrin solution at 40 to 70° C. at a speed of 3 to 5 mL / min, stirring for 2 to 4 hours at a speed of 600 to 1000 r / min, and continuing to stir for 4 to 6 hours after stopping the addition of liquid to obtain a volatile drug mixture; (c) placing the volatile drug mixture obtained in step (b) in a 2-5° C. environment and freezing it for 12-24 hours, filtering it to obtain a filter residue; (d) Drying the filter residue at 30-50°C to obtain an inclusion compound of the volatile drug.

2. The anti-edema and analgesic plaster according to claim 1, characterized in that: The conditions of the CO2 supercritical extraction are: extraction pressure of 28 MPa, extraction temperature of 42°C, decomposition pressure of 6 MPa, decomposition temperature of 42°C, and extraction time of 3 hours.

3. The anti-edema and analgesic plaster according to claim 1, characterized in that: The ratio of the total mass of the volatile drug to the mass of β-cyclodextrin is 1:

6.

4. The anti-edema and analgesic plaster according to claim 1, characterized in that: The medicinal plaster matrix comprises the following components in parts by weight: 1400-1600 parts of rubber, 0-100 parts of barium white, 180-200 parts of zinc oxide, 900-1100 parts of rosin, 2650-2800 parts of liquid paraffin and 240-320 parts of vaseline.

5. The anti-edema and analgesic plaster according to claim 4, characterized in that: The preparation method of the medicinal plaster matrix is: (i) Cut and crush the rubber into pieces, and soak it in gasoline until the rubber is fully swollen to obtain A; (ii) heating and dissolving the rosin to obtain B; (iii) Mix A, B, barium white, zinc oxide, liquid paraffin and vaseline together and stir evenly to obtain a plaster base.

6. A method for preparing the swelling-reducing and analgesic plaster according to any one of claims 1 to 5, characterized in that: The preparation method of the detumescent and analgesic plaster comprises the following steps: weighing belladonna fluid extract according to the component content, concentrating to obtain a thick paste containing belladonna with a relative density of 1.2 to 1.3 at 65 to 70° C.; then adding the thick paste containing belladonna, traumatic and rheumatic fluid extract, inclusion compound of volatile drugs, maple resin, camphor and artificial musk into a medicinal plaster matrix, mixing evenly and applying the mixture on a non-woven fabric material, and drying to obtain the detumescent and analgesic plaster.

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