Strong oxide alkaline medical disinfection cleaning agent and preparation method thereof

Abstract

The invention discloses a strong oxide alkaline medical disinfection cleaning agent and a preparation method thereof. The medical disinfection cleaning agent comprises embedded slow-release particles containing nano metal peroxide in an alkaline environment. The nano metal peroxide comprises one or more of sodium peroxide, calcium peroxide, magnesium peroxide, zinc peroxide, barium peroxide and titanium peroxide. A sustained-release embedding material used for embedding the sustained-release particles comprises one of polyacrylic acid, polydopamine and sodium alginate. The embedding treatment adopts a reverse microemulsion method or a gas diffusion method. The medical disinfection cleaning agent provided by the invention ensures an excellent cleaning effect in an alkaline environment, continuously releases strong oxidizing substances through the nano slow-release structure, and achieves a good continuous sterilization effect.

Description

Technical Field

[0001] The invention belongs to the technical field of cleaning agents, and in particular relates to a strong oxide alkaline medical disinfecting cleaning agent and a preparation method thereof. Background Art

[0002] In medical cleaning, we often encounter stains such as protein, grease, iodine, starch, etc. Hospitals usually use alkaline cleaning agents for cleaning. However, alkaline cleaning agents have the following problems:

[0003] (1) In actual medical environments, especially when facing unknown pathogens, aerosols are inevitably generated during the cleaning process, causing the spread of pathogenic microorganisms. However, the alkaline cleaning agents currently on the market do not have a bactericidal function and cannot effectively control microbial contamination.

[0004] (2) Traditional disinfection factors cannot exist stably in an alkaline cleaning agent environment.

[0005] (3) Alkaline cleaning agents are not effective in treating highly adherent eschar.

[0006] Nowadays, the requirements for cleaning of medical devices are getting higher and higher, so there is an urgent need for an alkaline cleaning agent that has a bactericidal effect while achieving the same cleaning effectiveness. Summary of the invention

[0007] Based on the deficiencies of the prior art, the purpose of the present invention is to provide a low-odor, high-efficiency, strong-oxidizing alkaline medical disinfectant cleaning agent with disinfection function and a preparation method thereof. In an alkaline cleaning agent environment, while ensuring excellent cleaning effects, the strong oxidizing substances are continuously released through a nano-sustained release structure to achieve a good sustained bactericidal effect.

[0008] In order to achieve the above purpose, this application adopts the following technical solutions:

[0009] In a first aspect, the present invention provides a strong oxidizing alkaline medical disinfectant cleaning agent, comprising embedded sustained-release particles containing nano-metal peroxides in an alkaline environment.

[0010] In the above technical solution, the nano metal peroxide includes sodium peroxide (Na 2 O 2 ), calcium peroxide (CaO 2 ), magnesium peroxide (MgO 2 )、ZnO 2 ), barium peroxide (BaO 2 ) and titanium peroxide (TiO x )

[0011] In the above technical solution, the embedding material used for embedding the sustained-release particles includes one of polyacrylic acid (PAA), polydopamine (PDA) and sodium alginate (SA).

[0012] In the above technical solutions, the embedding treatment adopts the reverse microemulsion method or the gas diffusion method.

[0013] In the above technical scheme, the following raw materials are used to prepare: hydrogen peroxide solution, sodium dihydrogen phosphate (NaH 2 PO 4 ), ammonia (NH 3 ·H 2 O), embedding material, sodium percarbonate, OH-donor, chlorine metal salt (XClx), surfactant, benzotriazole (BTA), sodium hexametaphosphate.

[0014] In the above technical solution, the OH- donor is NaOH, KOH, Ca(OH) 2 One of them.

[0015] In the above technical solution, the chlorine metal salt (XClx) is CaCl 2 , NaCl, KCl.

[0016] In a second aspect, the present invention provides a method for preparing the above-mentioned medical disinfectant cleaning agent, comprising the following steps:

[0017] S1. Place the embedding material, metal chloride salt (XClx), sodium dihydrogen phosphate (NaH 2 PO 4 ) and a surfactant are added into an appropriate amount of deionized water, and ultrasonic treatment is performed to make the components dispersed uniformly;

[0018] S2, stirring the ultrasonic solution at a constant speed, while slowly adding ammonia water;

[0019] S3, slowly add hydrogen peroxide solution to make the reaction proceed smoothly;

[0020] S4. When the solution turns into a light yellow viscous liquid, use a precipitant to precipitate, then wash it with ammonia water and then with anhydrous ethanol under centrifugal state;

[0021] S5, drying the cleaned CaO2 precipitate;

[0022] S6, premixing sodium percarbonate, sodium hexametaphosphate and sodium dihydrogen phosphate to obtain a mixed material A;

[0023] S7, premixing an OH-donor, a surfactant, and benzotriazole (BTA) to obtain a mixed material B;

[0024] S8. Fully mix the dried CaO2 precipitate, mixed material A and mixed material B to form a homogeneous powder, thereby obtaining the medical disinfectant cleaning agent.

[0025] In the above technical solution, the following steps are also included:

[0026] S9: Take an appropriate amount of the medical disinfectant cleaning agent and dissolve it in water to obtain a liquid for use of the medical disinfectant cleaning agent.

[0027] The beneficial effects of the present invention are:

[0028] (1) Both cleaning and sterilization functions:

[0029] Existing alkaline cleaning agents usually only have excellent cleaning effects but no sterilization function. The strong oxidizing alkaline medical disinfection cleaning agent of the present invention can not only ensure good cleaning effects, but also continuously release strong oxidizing properties through the nano-sustained release structure to achieve continuous sterilization, effectively solving the problem of single function of traditional products. At the same time, it can solve the problem of highly adhesive eschar and other substances attached to medical devices.

[0030] For example, in places with extremely high hygiene requirements such as hospitals, the use of the invented product can kill various possible pathogens while cleaning medical devices, equipment and other items, thereby reducing the risk of cross infection.

[0031] (2) Disinfection factors exist stably in an alkaline environment:

[0032] Traditional disinfection factors cannot exist stably in alkaline cleaning agent environments, which limits the application of disinfection functions in alkaline cleaning scenarios. The present invention adopts slow-release encapsulation technology to embed nano-metal peroxides in specific materials, such as polyacrylic acid, polydopamine, sodium alginate, etc., so that they can stably release disinfection factors in an alkaline environment, thus overcoming this defect of traditional products.

[0033] Take sodium peroxide as an example. If it is not encapsulated, it may decompose quickly in an alkaline environment and fail to play a sustained sterilization role. However, after encapsulation, it can stably release hydrogen peroxide over a certain period of time, ensuring the durability of the disinfection effect.

[0034] (3) Low odor:

[0035] Compared with some traditional disinfection products (chlorine-containing products), the product of the present invention has the advantage of low odor. During use, no pungent odor is generated, which is more user-friendly and is particularly suitable for places that are sensitive to odors, such as hospital wards, laboratories, etc.

[0036] For example, when this product is used for cleaning and disinfection in a relatively closed environment of a hospital, the strong odor will not affect the comfort and working environment of medical staff.

[0037] (4) High efficiency:

[0038] The high efficiency of the product of the present invention is reflected in its powerful cleaning and sterilization effects. The strong oxidizing property of nano-metal peroxide can quickly kill various germs, while the alkaline environment can effectively remove various stains. The combination of the two greatly improves the overall performance of the product.

[0039] For example, when cleaning hospital surgical instruments, blood stains, dirt, etc. can be quickly removed, while killing possible pathogens such as bacteria and viruses, ensuring the hygiene and biosafety of instruments and equipment.

[0040] (5) Continuous sterilization:

[0041] Due to the adoption of the nano slow-release structure, the product of the present invention can continuously release strong oxidative disinfection factors to achieve a long-term sterilization effect. Compared with traditional disposable disinfection products, it can better meet the needs of long-term health protection.

[0042] (6) Reduce the risk of microbial contamination:

[0043] In practical applications, existing alkaline cleaning agents may cause microorganisms to spread during the cleaning process, increasing the risk of contamination. However, the product of the present invention has a sterilization function, can effectively control the spread of microorganisms, and reduce the risk of contamination.

[0044] (7) Improve cleaning effect:

[0045] Although some cleaning agents with antibacterial function have the problem of poor cleaning effect, the product of the present invention does not sacrifice the cleaning effect while ensuring the sterilization function. On the contrary, due to its synergistic effect, it increases the cleaning effect of removing highly viscous and difficult-to-clean substances such as eschar. It can effectively remove various stains and ensure that the items after cleaning are clean and tidy.

[0046] (8) Expanding application areas:

[0047] Since the product of the present invention has the dual functions of cleaning and sterilization, and the disinfection factor exists stably in an alkaline environment, it can be expanded to more application fields. For example, it can be used not only in places with high hygiene requirements such as hospitals and laboratories, but also in food processing, hotels, animal husbandry and other industries to meet the needs of cleaning and disinfection in different fields.

[0048] For example, in the food processing industry, this product can be used to kill possible bacteria while cleaning equipment and sites, ensuring the safety and hygiene of food. DETAILED DESCRIPTION

[0049] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. The present invention can be implemented in many different forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided so that this disclosure will be thorough and complete, and the concept of the present invention will be fully conveyed to those skilled in the art, and the present invention will only be limited by the claims.

[0050] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0051] The invention provides a strong oxidizing alkaline medical disinfecting cleaning agent, comprising embedded slow-release particles containing nano metal peroxides in an alkaline environment.

[0052] Nano-metal peroxides include but are not limited to sodium peroxide (Na 2 O 2 ), calcium peroxide (CaO 2 ), magnesium peroxide (MgO 2 )、ZnO 2 ), barium peroxide (BaO 2 ) and titanium peroxide (TiO x )

[0053] The sustained-release embedding material used for embedding the sustained-release particles includes, but is not limited to, one of polyacrylic acid (PAA), polydopamine (PDA) and sodium alginate (SA).

[0054] The embedding treatment adopts the reverse microemulsion method or the gas diffusion method.

[0055] As one embodiment, the medical disinfectant cleaning agent of the present invention is prepared from the following raw materials: hydrogen peroxide solution, sodium dihydrogen phosphate (NaH 2 PO 4 ), ammonia (NH 3 ·H 2 O), embedding material, sodium percarbonate, OH-donor, chlorine metal salt (XClx), surfactant, benzotriazole (BTA), sodium hexametaphosphate.

[0056] In the present invention, hydrogen peroxide solution, chlorine metal salt (XClx), sodium dihydrogen phosphate (NaH 2 PO 4 ), ammonia (NH 3 ·H 2 O) The embedding material is used to prepare nano sustained-release encapsulated metal salts.

[0057] Sodium percarbonate continuously produces hydrogen peroxide in the system to stabilize the oxidation potential and provides a certain amount of -OH ions through its hydrolysis products to assist in pH stabilization.

[0058] OH-donors are the main components that provide -OH and are also directly involved in the saponification reaction.

[0059] Surfactants increase the surface active components, which can increase the overall dissolution rate, directly participate in decontamination, and solubilize and stabilize the slow-release components.

[0060] Sodium hexametaphosphate and sodium dihydrogen phosphate exist synergistically as stabilizers and pH regulators for hydrogen peroxide.

[0061] In the present invention, the embedding material may be an acidic swelling material, including but not limited to polyacrylic acid (PAA), polydopamine (PDA), sodium alginate (SA) and the like.

[0062] The OH- donor can be NaOH, or other alkali metal elements such as K and Ca.

[0063] The chlorine metal salt (XClx) can be CaCl 2 , it can also be other metal elements such as Na, K, etc.

[0064] The surfactant can be at least one of sodium dodecylbenzene sulfonate, sodium α-olefin sulfonate, sodium dodecyl sulfate, dioctyl sodium sulfosuccinate, disodium monolauryl sulfosuccinate, sodium fatty acid methane sulfonate, polyoxyethylene lauryl ether phosphate salt, nonylphenol polyoxyethylene ether sulfosuccinic acid monoester disodium salt, hexadecyltrimethylammonium bromide, dodecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, and hexadecyltrimethylammonium chloride.

[0065] As one embodiment, the medical disinfectant cleaning agent of the present invention is sustained-release nano calcium peroxide (nCaO2@PDA), and the raw materials for preparing the product are as follows:

[0066] Hydrogen peroxide solution (30%), sodium dihydrogen phosphate (NaH 2 PO 4 ), ammonia (NH 3 ·H 2 O, 1 mol / L), cetyltrimethylammonium bromide (CTAB), polydopamine (PDA), sodium percarbonate, sodium hydroxide, sodium dodecylbenzenesulfonate (SDBS), calcium chloride, sodium α-olefinsulfonate (AOS), benzotriazole (BTA), sodium hexametaphosphate.

[0067] The preparation method of the medical disinfectant cleaning agent (reverse microemulsion method) is:

[0068] (1) Ultrasonic dispersion: Calcium chloride (CaCl 2 ), sodium dihydrogen phosphate (NaH 2 PO 4 ), cetyltrimethylammonium bromide (CTAB) and polydopamine (PDA) are added into appropriate amount of deionized water, placed in an ultrasonic cleaner for ultrasonic treatment for 15 minutes at 45-50 Hz, and all the components are fully dispersed.

[0069] (2) Stirring at a constant speed: The sonicated solution was transferred to a conical flask, placed on a magnetic stirrer, and stirred at a constant speed of 270 r / min. At the same time, 1 mol / L ammonia (NH 3 ·H 2 O).

[0070] (3) Accurately add hydrogen peroxide: Use a constant flow pump to slowly add 14 ml of 30% hydrogen peroxide solution, and control the drop rate to ensure a smooth reaction.

[0071] (4) Precipitation and washing: When the solution becomes a light yellow viscous liquid, use a precipitant (sodium hydroxide) to precipitate, and then, under centrifugal conditions, first wash with ammonia (NH 3 ·H 2 O) was washed three times and then washed twice with anhydrous ethanol to improve the purity of the product.

[0072] (5) Drying and storage: Place the cleaned CaO2 precipitate in a vacuum drying oven, dry at 75°C for 2.5 h until completely dry, and store in a sealed container.

[0073] (6) Sodium percarbonate, sodium hexametaphosphate and sodium dihydrogen phosphate are premixed, ground and sieved at low temperature, and particles with a particle size of no more than 150 μm are obtained to obtain a mixed material.

[0074] (7) Sodium hydroxide, sodium dodecylbenzene sulfonate (SDBS), sodium α-olefin sulfonate (AOS), and benzotriazole (BTA) are added into a secondary mixing tank and mixed to obtain a mixed material.

[0075] (8) The mixed materials in steps 5 to 7 are put into a medicine powder mixer and mixed thoroughly to form a homogeneous powder, which is the strong oxidizing alkaline medical disinfectant cleaning agent of the present invention, and then stored in a well-sealed container.

[0076] (9) Take the above product and dissolve it in water (every 2.5g of the product is dissolved in 1000g of water) to obtain a strong oxidizing alkaline medical disinfectant cleaning agent liquid.

[0077] The technical solution of the present invention is described below in conjunction with specific embodiments.

[0078] Example 1

[0079] Disinfectant raw materials: hydrogen peroxide solution (30%) 16.51 kg, sodium dihydrogen phosphate (NaH 2 PO 4 )0.47kg, ammonia water (NH 3 ·H 2 O, 1mol / L) 16.51kg, cetyltrimethylammonium bromide (CTAB) 0.94kg, polydopamine (PDA) 2.13kg, sodium percarbonate 11.62kg, sodium hydroxide 43.36kg, sodium dodecylbenzene sulfonate (SDBS) 0.24kg, calcium chloride 5.31kg, sodium α-olefin sulfonate (AOS) 0.12kg, benzotriazole (BTA) 0.04kg, sodium hexametaphosphate 2.75kg.

[0080] Disinfectant preparation method:

[0081] (1) Ultrasonic dispersion: Calcium chloride (CaCl 2 )5.31kg, sodium dihydrogen phosphate (NaH 2 PO 4 )0.37kg, cetyltrimethylammonium bromide (CTAB)0.94kg, polydopamine (PDA)2.13kg are added into appropriate amount of deionized water, put into ultrasonic cleaning instrument and ultrasonically treated for 15 minutes at 45-50Hz, and all the components are fully dispersed.

[0082] (2) Stirring at a constant speed: The sonicated solution was transferred to a conical flask, placed on a magnetic stirrer, and stirred at a constant speed of 270 r / min. At the same time, 1 mol / L ammonia (NH 3 ·H 2 O)4.13kg.

[0083] (3) Accurately adding hydrogen peroxide: Use a constant flow pump to slowly add 16.51 kg of 30% hydrogen peroxide solution, and control the adding speed to ensure a smooth reaction.

[0084] (4) Precipitation and washing: When the solution becomes a light yellow viscous liquid, use 0.14 kg of precipitant (sodium hydroxide) for precipitation, and then wash with ammonia (NH 3 ·H 2 O) 12.38 kg was washed three times and then washed twice with anhydrous ethanol to improve the purity of the product.

[0085] (5) Drying and storage: Place the cleaned CaO2 precipitate in a vacuum drying oven, dry at 75°C for 2.5 h until completely dry, and store in a sealed container.

[0086] (6) 11.62 kg of sodium percarbonate, 2.75 kg of sodium hexametaphosphate and sodium dihydrogen phosphate (NaH2 PO 4 ) After 0.1 kg of premixing, low-temperature grinding and sieving are carried out to obtain particles with a particle size not greater than 150 μm to obtain a mixed material.

[0087] (7) 43.22 kg of sodium hydroxide, 0.24 kg of sodium dodecylbenzene sulfonate (SDBS), 0.12 kg of sodium α-olefin sulfonate (AOS), and 0.04 kg of benzotriazole (BTA) were added into a secondary mixing barrel and mixed to obtain a mixed material.

[0088] (8) The mixed materials in steps 5 to 7 are put into a medicine powder mixer and mixed thoroughly to form a homogeneous powder, which is the strong oxidizing alkaline medical disinfectant cleaning agent of the present invention, and then stored in a well-sealed container.

[0089] (9) Take the above product and dissolve it in water (every 2.5g of the product is dissolved in 1000g of water) to obtain a strong oxidizing alkaline medical disinfectant cleaning agent liquid.

[0090] Example 2

[0091] Disinfectant raw materials: hydrogen peroxide solution (30%) 16.32kg, sodium dihydrogen phosphate (NaH 2 PO 4 )0.47kg, ammonia water (NH 3 ·H 2 O, 1mol / L) 16.32kg, cetyltrimethylammonium bromide (CTAB) 0.93kg, sodium alginate (Sodium alginate, SA) 3.27kg, sodium percarbonate 8.48kg, sodium hydroxide 45.86kg, sodium dodecylbenzene sulfonate (SDBS) 0.23kg, calcium chloride 5.25kg, α-olefin sulfonate sodium (AOS) 0.12kg, benzotriazole (BTA) 0.03kg, sodium hexametaphosphate 2.72kg.

[0092] Disinfectant preparation method:

[0093] (1) Ultrasonic dispersion: Calcium chloride (CaCl 2 ) 5.25kg, sodium dihydrogen phosphate (NaH 2 PO 4 ) 0.38kg, cetyltrimethylammonium bromide (CTAB) 0.93kg, sodium alginate (SA) 3.27kg are added into appropriate amount of deionized water, and placed into an ultrasonic cleaner for ultrasonic treatment for 15 minutes at 45-50Hz, until all the components are fully dispersed.

[0094] (2) Stirring at a constant speed: The sonicated solution was transferred to a conical flask, placed on a magnetic stirrer, and stirred at a constant speed of 270 r / min. At the same time, 1 mol / L ammonia (NH 3 ·H 2 O)4.15kg.

[0095] (3) Accurately adding hydrogen peroxide: Use a constant flow pump to slowly add 16.32 kg of 30% hydrogen peroxide solution, and control the adding speed to ensure a smooth reaction.

[0096] (4) Precipitation and washing: When the solution becomes a light yellow viscous liquid, use 0.16 kg of precipitant (sodium hydroxide) for precipitation, and then wash with ammonia (NH 3 ·H 2 O) 12.17 kg was washed three times and then washed twice with anhydrous ethanol to improve the purity of the product.

[0097] (5) Drying and storage: Place the cleaned CaO2 precipitate in a vacuum drying oven, dry at 75°C for 2.5 h until completely dry, and store in a sealed container.

[0098] (6) 8.48 kg of sodium percarbonate, 2.72 kg of sodium hexametaphosphate and sodium dihydrogen phosphate (NaH 2 PO 4 ) After 0.09 kg of the raw materials are pre-mixed, they are ground and sieved at low temperature to obtain particles with a particle size not greater than 150 μm to obtain a mixed material.

[0099] (7) 45.7 kg of sodium hydroxide, 0.23 kg of sodium dodecylbenzene sulfonate (SDBS), 0.12 kg of sodium α-olefin sulfonate (AOS), and 0.03 kg of benzotriazole (BTA) were added into a secondary mixing barrel and mixed to obtain a mixed material.

[0100] (8) The mixed materials in steps 5 to 7 are put into a medicine powder mixer and mixed thoroughly to form a homogeneous powder, which is the strong oxidizing alkaline medical disinfectant cleaning agent of the present invention, and then stored in a well-sealed container.

[0101] (9) Take the above product and dissolve it in water (every 2.5g of the product is dissolved in 1000g of water) to obtain a strong oxidizing alkaline medical disinfectant cleaning agent liquid.

[0102] Example 3

[0103] Disinfectant raw materials: hydrogen peroxide solution (30%) 18.36kg, sodium dihydrogen phosphate (NaH 2 PO 4 )0.52kg, ammonia water (NH 3 ·H 2O, 1mol / L) 18.36kg, cetyltrimethylammonium bromide (CTAB) 1.05kg, polydopamine (PDA) 3.68kg, sodium percarbonate 12.92kg, sodium hydroxide 35.72kg, sodium dodecylbenzene sulfonate (SDBS) 0.26kg, calcium chloride 5.9kg, sodium α-olefin sulfonate (AOS) 0.13kg, benzotriazole (BTA) 0.04kg, sodium hexametaphosphate 3.06kg.

[0104] Disinfectant preparation method:

[0105] (1) Ultrasonic dispersion: Calcium chloride (CaCl 2 )5.90kg, sodium dihydrogen phosphate (NaH 2 PO 4 ) 0.4kg, cetyltrimethylammonium bromide (CTAB) 1.05kg, polydopamine (PDA) 3.68kg are added into appropriate amount of deionized water, put into ultrasonic cleaning apparatus for ultrasonic treatment for 15 minutes at 45-50Hz, and all components are fully dispersed.

[0106] (2) Stirring at a constant speed: The sonicated solution was transferred to a conical flask, placed on a magnetic stirrer, and stirred at a constant speed of 270 r / min. At the same time, 1 mol / L ammonia (NH 3 ·H 2 O)4.18kg.

[0107] (3) Accurately adding hydrogen peroxide: Use a constant flow pump to slowly add 18.36 kg of 30% hydrogen peroxide solution, and control the adding speed to ensure a smooth reaction.

[0108] (4) Precipitation and washing: When the solution becomes a light yellow viscous liquid, use 0.16 kg of precipitant (sodium hydroxide) for precipitation, and then wash with ammonia (NH 3 ·H 2 O) 14.18 kg was washed three times and then washed twice with anhydrous ethanol to improve the purity of the product.

[0109] (5) Drying and storage: Place the cleaned CaO2 precipitate in a vacuum drying oven, dry at 75°C for 2.5 h until completely dry, and store in a sealed container.

[0110] (6) 12.92 kg of sodium percarbonate, 3.06 kg of sodium hexametaphosphate and sodium dihydrogen phosphate (NaH 2 PO 4 ) After 0.12 kg of premixing, low-temperature grinding and sieving are carried out to obtain particles with a particle size not greater than 150 μm to obtain a mixed material.

[0111] (7) 35.56 kg of sodium hydroxide, 0.26 kg of sodium dodecylbenzene sulfonate (SDBS), 0.13 kg of sodium α-olefin sulfonate (AOS), and 0.04 kg of benzotriazole (BTA) were added into a secondary mixing barrel and mixed to obtain a mixed material.

[0112] (8) The mixed materials in steps 5 to 7 are put into a medicine powder mixer and mixed thoroughly to form a homogeneous powder, which is the strong oxidizing alkaline medical disinfectant cleaning agent of the present invention, and then stored in a well-sealed container.

[0113] (9) Take the above product and dissolve it in water (every 2.5g of the product is dissolved in 1000g of water) to obtain a strong oxidizing alkaline medical disinfectant cleaning agent liquid.

[0114] Comparative Example 1 (antibacterial alkaline cleaning agent)

[0115] Disinfectant formula: 11kg acetylsalicylic acid, sodium dihydrogen phosphate (NaH 2 PO 4 ) 0.2kg, sodium percarbonate 23kg, sodium hydroxide 61kg, sodium dodecylbenzene sulfonate (SDBS) 0.1kg, benzotriazole (BTA) 0.04kg, sodium hexametaphosphate 4kg, sodium α-olefin sulfonate (AOS) 0.12kg, sodium bicarbonate 0.52kg.

[0116] Preparation method of disinfectant: Mix according to the above formula.

[0117] Comparative Example 2 (Multi-enzyme alkaline cleaning agent)

[0118] Disinfectant formula: 12.2kg protease, 8.76kg lipase, 2.04kg amylase, 0.2kg chelating agent disodium EDTA, 24kg surfactant, 23kg sodium hydroxide, 21kg pH buffer, 4.5kg enzyme activity stabilizer, 4.3kg sodium benzoate.

[0119] Preparation method of disinfectant: Mix according to the above formula.

[0120] Comparative Example 3 (Alkaline Cleaning Agent for Medical Devices)

[0121] Disinfectant formula: 15kg potassium hydroxide, 10kg sodium dodecylbenzene sulfonate, 2kg fatty alcohol polyoxyethylene ether, 4kg disodium EDTA, 4kg sodium silicate, 0.5kg silicone defoamer, and 64.5kg deionized water.

[0122] Preparation method of disinfectant: Mix according to the above formula.

[0123] Experimental procedures

[0124] The cleaning agents prepared in Examples 1-3 and Comparative Examples 1-3 were subjected to performance tests, and the test methods were as follows:

[0125] Microbial killing experiment - refer to the Disinfection Technical Specifications 2016 Edition / GB27949-2020;

[0126] Physical, chemical and corrosive tests---Disinfection Technical Specifications 2002 Edition;

[0127] Evaluation of cleaning effect---refer to "Hospital Sterilization Supply Center Part 3: Cleaning, Disinfection and Sterilization Technical Operation Specifications (WS 310.3-2016)";

[0128] Odor test---ISO 12219-7:2017.

[0129] The test results are shown in Table 1 below:

[0130] Table 1 Performance test results

[0131]

[0132] It can be seen from Table 1 that after adding 15-18% peroxide (Examples 1-3 and Comparative Example 1) to the alkaline cleaning agent system, the overall bactericidal performance is good. After adding peroxide, the disadvantages of the existing alkaline cleaning agent formula (Comparative Example 3) that it cannot kill microorganisms and cannot effectively remove eschar are compensated, and the microbial killing effect is also better than the alkaline multi-enzyme cleaning agent (Comparative Example 2) that claims to have a disinfection function. However, simply adding peroxide to the alkaline cleaning agent system (Comparative Example 1) cannot significantly improve the bactericidal performance, because the stability of peroxide in a strong alkaline environment is very poor, and it will be quickly inactivated in the solution. The strong alkaline environment also inhibits the efficiency of peroxide reacting with water to generate hydrogen peroxide, thereby affecting its killing efficiency and stability in continuous use.

[0133] Therefore, in Examples 1-3, we applied the slow-release nano-metal peroxide preparation technology to "fix" the oxidizing property of hydrogen peroxide in the metal peroxide to avoid being affected by the external pH value change, and used the reverse microemulsion method, gas diffusion method and other methods combined with the slow-release embedding material nCaO2@PDA or nCaO2@SA to achieve the slow-release function of the oxidative active substance. Moreover, the sensitivity of the metal peroxide itself to high pH value during the reaction and hydrolysis is lower than that of other peroxides (Comparative Example 1), which is manifested in the increase of killing efficiency (logarithm of killing of Escherichia coli) and the improvement of stability (logarithm of killing of Escherichia coli after continuous use for 4 hours in the field simulation experiment), thereby achieving both strong saponification cleaning ability under strong alkalinity and microbial killing ability of continuous release of peroxide, and also having an excellent cleaning effect of removing eschar comparable to that of multi-enzyme cleaning agents.

[0134] The difference between Example 2 and Example 1 is that sodium alginate (SA) is used as an embedding agent to increase the embedding agent content and correspondingly increase the OH - The ion concentration of nCaO2@SA solution was formed in a strong alkaline environment. In this system, due to the high pH value, a better cleaning effect was obtained, with an average ATP detection value of 8RLU and a protein residue of 0.06μg / cm 2 , but its killing effect and stability are slightly weaker than those of Example 1, because in a high pH environment, the rate at which CaO2 and water produce hydrogen peroxide is limited, and the generated hydrogen peroxide decomposes faster in the solution. The difference between Example 3 and Example 1 is that the OH - The ion concentration is adjusted to stabilize the pH value at about 10. The rate at which CaO2 reacts with water to release hydrogen peroxide in this pH environment is basically unrestricted. Therefore, a stronger microbial killing ability is obtained, and its killing ability (lg4) is greatly improved compared with Example 2 (lg2.8). However, due to OH - The ion concentration is low and its cleaning effect (0.21μg / cm 2 ) is weaker than that of Examples 1 and 2, but its average ATP detection value is 11RLU, which is not much different from that of Example 1 (12RLU). The reason is that ATP mainly detects the respiration of living cells, and the strong oxidizing property in Example 3 can kill living cells, thus resulting in a lower ATP value.

[0135] In Comparative Example 1, a strong alkaline cleaning agent with peroxide but without sustained release function is simulated, in which acetylsalicylic acid and sodium percarbonate can react in the solution to produce peroxyanhydride, which plays a good role in killing microorganisms (killing logarithm lg2.6). Since the pH value of the system in Comparative Example 1 is 14+, it also has good cleaning ability, and its average ATP detection value is 17RLU, and the average protein residue is 0.22μg / cm 2, which is close to the cleaning performance of Example 3. However, due to the extremely high pH value and the lack of sustained-release components, the continuous use stability of Comparative Example 1 is very poor, and its killing logarithm is only 1.3 after 4 hours. In Comparative Example 2, it is a common formula of a composite alkaline multi-enzyme cleaning agent. Due to its relatively low pH value, its cleaning effect is worse than that of Examples 1-3, but it is worth noting that the qualified rate of removing eschar is close to that of Comparative Example 2, which proves that the ability to remove eschar comparable to the effect of multi-enzymes can be achieved in a system with peroxide. However, as an important technical indicator of the present invention, the microbial killing ability of Comparative Example 2 is poor (lg1.2). In Comparative Example 3, it is a typical alkaline cleaning agent formula for medical devices. Its strong alkalinity of pH value 14+ gives it excellent cleaning power, but because it does not have a microbial killing component, its microbial killing logarithm is only 0.21, mainly relying on strong alkalinity to destroy the lipoprotein structure on the cell surface to achieve antibacterial effect.

[0136] By comparison, the solutions of Examples 1-3 are more in line with the technical requirements of strong oxidizing alkaline medical disinfectant cleaning agents.

[0137] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A strong oxidizing alkaline medical disinfectant cleaning agent, characterized in that: It includes embedded sustained-release particles containing nano-metal peroxides in an alkaline environment.

2. The medical disinfectant cleaning agent according to claim 1, characterized in that: The nano metal peroxide includes one or more of sodium peroxide, calcium peroxide, magnesium peroxide, zinc peroxide, barium peroxide and titanium peroxide.

3. The medical disinfectant cleaning agent according to claim 1, characterized in that: The embedding material used for embedding the sustained-release particles includes one of polyacrylic acid, polydopamine and sodium alginate.

4. The medical disinfectant cleaning agent according to claim 1, characterized in that: The embedding treatment adopts the reverse microemulsion method or the gas diffusion method.

5. The medical disinfectant cleaning agent according to claim 1, characterized in that: The invention is prepared from the following raw materials: hydrogen peroxide solution, sodium dihydrogen phosphate, ammonia water, embedding material, sodium percarbonate, OH-donor, chlorine metal salt, surfactant, benzotriazole and sodium hexametaphosphate.

6. The medical disinfectant cleaning agent according to claim 5, characterized in that: The OH-donor is one of NaOH, KOH, and Ca(OH)2.

7. The medical disinfectant cleaning agent according to claim 5, characterized in that: The chlorine metal salt is one of CaCl2, NaCl and KCl.

8. The method for preparing the medical disinfectant cleaning agent according to claim 5, characterized in that: The following steps are involved: S1. Add the embedding material, chlorometallic salt, sodium dihydrogen phosphate and surfactant into appropriate amount of deionized water, and perform ultrasonic treatment to make the components dispersed evenly; S2, stirring the ultrasonic solution at a constant speed, while slowly adding ammonia water; S3, slowly add hydrogen peroxide solution to make the reaction proceed smoothly; S4. When the solution turns into a light yellow viscous liquid, use a precipitant to precipitate, then wash it with ammonia water and then with anhydrous ethanol under centrifugal state; S5, drying the washed CaO2 precipitate; S6, premixing sodium percarbonate, sodium hexametaphosphate and sodium dihydrogen phosphate to obtain a mixed material A; S7, premixing the OH-donor, the surfactant, and benzotriazole to obtain a mixed material B; S8. Fully mix the dried CaO2 precipitate, mixed material A and mixed material B to form a homogeneous powder, thereby obtaining the medical disinfectant cleaning agent.

9. The preparation method according to claim 8, characterized in that: The following steps are also included: S9: Take an appropriate amount of the medical disinfectant cleaning agent and dissolve it in water to obtain a liquid for use of the medical disinfectant cleaning agent.

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