Multifunctional kit

Abstract

The invention provides a multifunctional kit which is internally provided with M electrochemical test strips and N dry chemical test strips, namely, the multifunctional kit with consumables can be matched with a multifunctional detection instrument to detect M electrochemical detection items and N dry chemical detection items, and through the arrangement of a sample tube mounting groove 311, a sampling groove 312, a TIP head grabbing groove 313 and a TIP head discarding groove 314, the detection efficiency is improved, and the detection efficiency is improved. Sampling and sample adding can be conveniently completed in one multifunctional kit, and then detection of M electrochemical detection items and N dry chemical detection items can be fully automatically carried out in cooperation with a multifunctional detection instrument.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the technical field of marker detection, and specifically to a multifunctional kit. Background Art

[0002] Most of the current detectors are single-function detectors. For example, a sphygmomanometer can measure blood pressure, a blood glucose meter can measure blood sugar, and a blood lipid meter can measure blood lipids.

[0003] In addition, current blood sugar and blood lipid testing equipment requires users to draw blood, use a pipette to suck blood samples, add samples to the display area of ​​the reagent card, and finally manually put the reagent card into the instrument for testing and reading. The above-mentioned sampling and adding operations are difficult and not suitable for general users.

[0004] Furthermore, if multiple inspection items need to be inspected, different inspection instruments need to be operated multiple times, and the user has many and complicated operation steps.

[0005] In order to cooperate with miniaturized testing instruments to carry out testing of various projects and improve the testing convenience of miniaturized testing instruments, it is necessary to design corresponding matching multifunctional test kits. Summary of the invention

[0006] The embodiment of the present disclosure provides a multifunctional kit 100, comprising:

[0007] An upper cover 10, a test strip support 20 and a box body 30 are sequentially arranged from top to bottom, and M electrochemical test strips and N dry chemical test strips are arranged between the upper cover 10 and the box body 30;

[0008] The upper cover 10 is provided with M electrochemical test strip sample addition holes 11 and N dry chemical test strip sample addition holes 12, and the M electrochemical test strip sample addition holes 11 and the N dry chemical test strip sample addition holes 12 both penetrate the upper and lower surfaces of the upper cover 10;

[0009] The box body 30 includes a sampling area 31 and a sample adding and testing area 32, wherein the sampling area 31 is provided with a sample tube installation slot 311, a sampling slot 312, a TIP head grabbing slot 313 and a TIP head discarding slot 314;

[0010] The sample tube installation groove 311 is used to support the sample tube 40 and communicate with the sample tube 40, and the sample tube installation groove 311 is in fluid communication with the sampling groove 312;

[0011] The test strip support 20 is disposed above the sample adding detection area 32 , and the test strip support 20 cooperates with the sample adding detection area 32 to fix and support the M chemical test strips and the N dry chemical test strips.

[0012] In some optional embodiments, the M electrochemical test strips and the N dry chemical test strips are disposed in the sample addition and detection area 32 .

[0013] In some optional embodiments, the test strip support 20 is disposed above the sample adding and detecting area 32 .

[0014] In some optional embodiments, the sample tube mounting groove 311 is connected to the sampling groove 312 through a U-shaped flow channel 315 .

[0015] In some optional embodiments, ultrasonic welding is used at the bend of the U-shaped flow channel (315) to form a sealing structure.

[0016] In some optional embodiments, the sample tube mounting groove (311) is in sealing contact with the sample tube (40) via an inclined conical surface, and the inclined conical surface can pierce the middle of the sealed tube cover of the sample tube (40).

[0017] In some optional embodiments, three centering spring pieces (3131) are arranged in the TIP head grabbing groove (313) to limit and fix the TIP head.

[0018] In some optional embodiments, two prompt springs (3113) are provided in the sample tube installation groove (311) for prompting the sample tube (40) to be installed in place when the sample tube (40) is installed in place.

[0019] In some optional embodiments, the M electrochemical test strip sample loading holes 11 and the N dry chemical test strip sample loading holes 12 are inverted frustums with hollow interiors.

[0020] In some optional embodiments, the horizontal projections of the sample application areas of the M electrochemical test strips and the sample application areas of the N dry chemical test strips do not overlap.

[0021] In some optional embodiments, the test strip support 20 is provided with M electrochemical test strip channels 21 stacked in a staggered manner, and an electrochemical sample loading guide groove 211 is provided at one end of the electrochemical test strip channel 21, and the electrochemical sample loading guide groove 211 of the lower electrochemical test strip channel 21 in two adjacent layers is exposed from the electrochemical sample loading guide groove 211 of the upper electrochemical test strip channel 21.

[0022] In some optional embodiments, the sample adding and detecting area 32 further includes a positioning guide plate 323 for positioning and guiding the box body 30 of the multifunctional reagent box 100 .

[0023] In some optional embodiments, the positioning guide plate 323 is provided with N dry chemical detection holes 322 , and the dry chemical detection holes 322 are arranged below the corresponding dry chemical test strips 321 .

[0024] In some optional embodiments, the test strip support 20 is provided with a protruding compression strip 24 protruding downward, and the protruding compression strip 24 is provided with N dry chemical sample addition flow guide holes 23, and the dry chemical sample addition flow guide holes 23 pass through the upper and lower surfaces of the protruding compression strip 24.

[0025] In some optional embodiments, the protruding pressing strip 24 is fixed to the positioning guide plate 323 via a positioning element, and the N dry chemical test strips 321 are disposed between the protruding pressing strip 24 and the positioning guide plate 323 .

[0026] In some optional embodiments, an electrochemical test strip 22 is attached to the upper surface or the lower surface of each electrochemical test strip channel 21 .

[0027] In some optional embodiments, the reaction end of each electrochemical test strip 22 is close to the electrochemical sample loading guide groove 211 of the corresponding electrochemical test strip channel 21, and the pin end of each electrochemical test strip 22 is away from the electrochemical sample loading guide groove 211 of the corresponding electrochemical test strip channel 21.

[0028] In some optional embodiments, the electrochemical test strip channel 21 is provided with an anti-siphon groove 212 between the electrochemical sample addition flow guide groove 211 and an end of the electrochemical test strip channel 21 away from the electrochemical sample addition flow guide groove 211 .

[0029] In order to provide a multifunctional test kit for a multifunctional detector, the multifunctional test kit provided in the embodiment of the present disclosure has M electrochemical test strips and N dry chemical test strips built in, that is, a multifunctional test kit with consumables, which can be used in conjunction with the multifunctional detection instrument to detect M electrochemical detection items and N dry chemical detection items, and by setting the sample tube installation slot 311, the sampling slot 312, the TIP head grabbing slot 313 and the TIP head discarding slot 314, sampling and adding of samples can be conveniently completed in a multifunctional test kit, and then the multifunctional detection instrument can be used to realize fully automatic detection of M electrochemical detection items and N dry chemical detection items. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Other features, objects and advantages of the present disclosure will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings. The drawings are only for the purpose of illustrating specific embodiments and are not to be considered as limiting the present disclosure. In the drawings:

[0031] Figure 1Ais an external stereoscopic schematic diagram of an embodiment 100 of a multifunctional kit according to the present disclosure;

[0032] Figure 1B for Figure 1A The schematic diagram of the multifunctional reagent kit 100 after the upper cover 10 is exploded from the test strip support 20 and the box body 30;

[0033] Figure 2A It is a three-dimensional schematic diagram of a test strip support 20 and a box body 30 after removing the upper cover 10 according to an embodiment of the multifunctional reagent box 100 of the present disclosure;

[0034] Figure 2B for Figure 2A The schematic diagram of the multifunctional reagent kit 100 after the two upper electrochemical test strips 22 and the rest of the kit are exploded;

[0035] Figure 2C for Figure 2B The multifunctional reagent kit 100 is shown as a schematic diagram after the test strip support 20 and the box body 30 are exploded;

[0036] Figure 2D yes Figure 2C The schematic diagram of the multifunctional reagent kit 100 after the dry chemical test strip 321 is exploded from the box body 30 is shown;

[0037] Figure 2E yes Figure 2D The multifunctional reagent kit 100 is shown as a three-dimensional schematic diagram observed from a lower perspective;

[0038] Figure 3 It is a three-dimensional schematic diagram of the sample tube 40, the detection circuit board 50, and the TIP head 60 assembled with the multifunctional reagent kit 100 according to the present disclosure;

[0039] Figure 4A and Figure 4B They are three-dimensional schematic diagrams of an embodiment of a sample tube 40 according to the present disclosure in an upright state and an inverted state respectively;

[0040] Figure 4C and Figure 4D Exploded views of an embodiment of a sample tube 40 according to the present disclosure in an upright state and an inverted state, respectively;

[0041] Figure 4E is a perspective schematic diagram of a sealing tube cover 42 according to the present disclosure in an upright state;

[0042] Figure 5 is a cross-sectional view of a sample tube mounting groove 311, a U-shaped flow channel 315, and a sample tube 40 in one embodiment of a multifunctional reagent kit 100 according to the present disclosure;

[0043] Figure 6 A cross-sectional view of a multifunctional reagent box sampling slot 312, a TIP head grabbing slot 313, and a U-shaped flow channel 315 in a sampling area 31 in one embodiment of a multifunctional reagent box 100 according to the present disclosure;

[0044] Fig. 7A and Figure 7B They are respectively an upper view and a lower view of an embodiment of the sampling area 31 in the multifunctional reagent kit 100 according to the present disclosure.

[0045] Description of reference numerals:

[0046] 100-multi-function test kit; 10-upper cover; 11-electrochemical test strip sample loading hole; 12-dry chemical test strip sample loading hole; 20-test strip support; 21-electrochemical test strip channel; 211-electrochemical sample loading flow guide groove; 212-anti-siphon groove; 22-electrochemical test strip; 221-reaction end of electrochemical test strip; 222-pin end of electrochemical test strip; 23-dry chemical sample loading flow guide hole; 24-protruding pressing strip; 30-box body; 31-sampling area; 311-sample tube installation groove; 3111-guide barrel; 3112-sample flow guide hole; 3113-prompt spring; 312-sampling slot; 313-TI P-head grabbing slot; 3131-centering spring clip; 314-TIP head discarding slot; 315-U-shaped flow channel; 3151-first flow channel; 3152-second flow channel; 3153-third flow channel; 3154-fourth flow channel; 3155-fifth flow channel; 32-sample loading and detection area; 321-dry chemical test strip; 3211-dry chemical sample loading area; 322-dry chemical detection hole; 323-positioning guide plate; 3231-positioning guide spring clip; 40-sample tube; 41-tube body; 42-sealed tube cover; 421-rubber plug; 4211-small circle hole; 422-breathable groove; 50-detection circuit board; 60-TIP head. DETAILED DESCRIPTION

[0047] Embodiments of the present disclosure are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present disclosure, and should not be construed as limiting the present disclosure.

[0048] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present disclosure may be combined with each other. The present disclosure will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0049] It should be understood that, in the description of the present disclosure, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "clockwise", "counterclockwise" and the like to indicate orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present disclosure and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present disclosure.

[0050] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present disclosure, unless otherwise specified, "plurality" means two or more, unless otherwise clearly specified.

[0051] In the present disclosure, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present disclosure can be understood according to the specific circumstances.

[0052] In the present disclosure, unless otherwise expressly specified and limited, a first feature being “above” or “below” a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being “above”, “above”, and “above” a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being “below”, “below”, and “below” a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0053] Reference below Figure 1A and Figure 1B ,in, Figure 1A is a three-dimensional schematic diagram of an embodiment of a multifunctional reagent kit 100 according to the present disclosure, Figure 1B for Figure 1A The multifunctional reagent kit 100 is shown as a schematic diagram after the upper cover 10 is exploded from the test strip support 20 and the box body 30 .

[0054] like Figure 1A and Figure 1B As shown, the multifunctional test kit 100 may include an upper cover 10, a test strip support 20 and a box body 30 arranged in sequence from top to bottom, and M electrochemical test strips and N dry chemical test strips arranged between the upper cover 10 and the box body 30. Here, M and N are positive integers, and M and N are 2 for example in the drawings of the present disclosure. It can be understood that the values ​​of M and N can be designed according to the actual scene requirements.

[0055] The upper cover 10 is provided with M electrochemical test strip sample addition holes 11 and N dry chemical test strip sample addition holes 12 .

[0056] The M electrochemical test strip sample loading holes 11 and the N dry chemical test strip sample loading holes 12 all penetrate the upper and lower surfaces of the upper cover 10 .

[0057] The M electrochemical test strip sample loading holes 11 correspond to the sample loading areas of the M electrochemical test strips one by one, and are used to load samples to the reaction areas of the corresponding electrochemical test strips below through the electrochemical test strip sample loading holes 11. The reaction areas of the electrochemical test strips can be fixed with active substances such as enzymes, and the blood reacts with the active substances such as enzymes in the electrochemical test strips through siphoning to generate microcurrents. The microcurrents generated by different concentrations of the substances to be tested are different. Subsequently, the electrochemical test results (for example, blood sugar levels, blood ketone levels, or uric acid levels) can be calculated by detecting the strength of the above current.

[0058] The N dry chemical test strip sample holes 12 correspond to the sample adding areas of the N dry chemical test strips one by one, and are used to add samples to the sample adding areas of the corresponding dry chemical test strips below through the dry chemical test strip sample holes 12. In this way, when the sample to be tested is added to the dry chemical test strip sample hole 12, the sample to be tested can enter the sample adding area of ​​the dry chemical test strip through the dry chemical test strip sample hole 12. In the uniform and rapid infiltration process, blood cells are filtered out, and the sample to be tested reacts with the enzymes and chemicals in the reaction layer, resulting in color changes, and the color intensity is proportional to the concentration of the test object. Subsequently, the reflection intensity can be measured on the dry chemical test strip sample hole 12, and the photoelectric conversion result can be obtained by photoelectric conversion, and then the dry chemical test result, such as the blood lipid test result, can be obtained through subsequent calculation.

[0059] The box body 30 may include a sampling area 31 and a sample adding and detecting area 32 .

[0060] The sampling area 31 is provided with a sample tube installation slot 311 , a sampling slot (or negative pressure suction slot) 312 , a TIP head grabbing slot 313 and a TIP head discarding slot 314 .

[0061] The sample tube mounting groove 311 is used to support the sample tube 40 and connect the sample tube 40 . The sample tube 40 may contain a sample to be tested (eg, a blood sample).

[0062] Here, the sample tube 40 may be provided with a sealed tube cover. The middle part of the tube cover of the sample tube 40 may be made of a relatively soft material. The above material may be pierced by a sharp structure. For example, it may be made of silicone. The portion where the sample tube mounting groove 311 contacts the tube cover of the sample tube 40 may pierce the middle part of the tube cover of the sample tube 40. When the tube cover of the sample tube 40 is turned down onto the sample tube mounting groove 311, the portion where the sample tube mounting groove 311 contacts the tube cover of the sample tube 40 may pierce the middle part of the sealed tube cover of the sample tube 40, and the sample tube mounting groove 311 and the sample tube 40 may form a sealed contact, so that the sample to be tested in the sample tube 40 may enter the sampling groove 312 under the action of negative pressure through the connecting flow channel between the sample tube mounting groove 311 and the sampling groove 312, thereby achieving the absorption of the sample to be tested.

[0063] The flow channel between the sampling slot 312 and the sample tube installation slot 311 is connected. In this way, after the sample tube 40 is installed in the sample tube installation slot 311, negative pressure is sucked into the sampling slot 312, and negative pressure can be generated in the sampling slot 312 and the sample tube 40, so that the sample to be tested in the sample tube 40 can enter the sampling slot 312 from the sample tube installation slot 311 through the connected flow channel, and the sample to be tested can be sucked from the sampling slot 312 manually or by automatic sample adding equipment.

[0064] The TIP head grabbing groove 313 and the TIP grabbing groove 312 can accommodate at least one TIP head.

[0065] Before adding samples, the TIP tip can be sucked from the TIP tip grabbing slot 313 by manual or automatic sample adding equipment and assembled on the sample suction head of a pipette gun or automatic sample adding equipment.

[0066] The TIP head discarding slot 314 is used to release the no longer needed TIP head to the TIP head discarding slot 314 after completing the sample suction and sample addition tasks.

[0067] M electrochemical test strips and N dry chemical test strips are arranged in the sample adding and testing area 32 .

[0068] Here, the detection items corresponding to the M electrochemical test strips may be the same or different. Optionally, the M electrochemical test strips may correspond to M different electrochemical detection items.

[0069] Here, the detection items corresponding to the N dry chemical test strips may be the same or different. Optionally, the N dry chemical test strips may correspond to N different dry chemical detection items.

[0070] It is understood that when M is greater than or equal to 2, the multifunctional reagent box 100 has at least two electrochemical test strips, which can support at least two electrochemical detection items. When N is greater than or equal to 2, the multifunctional reagent box 100 has at least two dry chemical test strips, which can support at least two dry chemical detection items.

[0071] The test strip support 20 is arranged above the sample loading detection area 32 of the box body 30. The test strip support 20 and the sample loading detection area 32 of the box body 30 cooperate to fix and support M chemical test strips and N dry chemical test strips, and ensure that the M electrochemical test strip loading holes 11 correspond to the sample loading areas of the M electrochemical test strips, and the N dry chemical test strip loading holes 12 correspond to the sample loading areas of the N dry chemical test strips.

[0072] Optionally, the M electrochemical test strip sample loading holes 11 and the N dry chemical test strip sample loading holes 12 can be designed as an inverted frustum shape with a hollow interior. Since the inner diameter of the inverted frustum is larger at the top and smaller at the bottom, it can facilitate liquid diversion during the sample loading process, reduce the requirements for the position accuracy of the M electrochemical test strip sample loading holes 11 and the N dry chemical test strip sample loading holes 12, and reduce the requirements for sample loading accuracy, that is, reduce the difficulty of sample loading for users or automatic sample loading equipment.

[0073] The multifunctional reagent kit 100 provided in the above embodiment can realize the detection of M electrochemical detection items and N dry chemical detection items in cooperation with a miniaturized detection instrument by arranging M electrochemical test strips and N dry chemical test strips, and by arranging a sample tube installation slot 311, a sampling slot 312, a TIP head grabbing slot 313, and a TIP head discarding slot 314, it is convenient to complete the operations of sample sampling, sample addition and detection in a multifunctional reagent kit 100, thereby simplifying the operation process and complexity.

[0074] Various implementations can be used here to set M electrochemical test strips and N dry chemical test strips between the upper cover 10 and the box body 30. In order to miniaturize the multifunctional test kit 100 as much as possible and effectively utilize the internal space of the multifunctional test kit 100, M electrochemical test strips and N dry chemical test strips can be arranged in multiple layers in an upper and lower manner, as long as it is possible to add samples to the sample adding area (or reaction area) of the corresponding electrochemical test strip through the electrochemical test strip sample adding hole 11 set in the upper cover 10, and it is possible to add samples to the sample adding area of ​​the corresponding dry chemical test strip through the dry chemical test strip sample adding hole 12 set in the upper cover 10.

[0075] In some optional implementations, please refer to Figure 2A and Figure 2B .in, Figure 2AFIG. 1 is a three-dimensional schematic diagram of a test strip support 20 and a box body 30 after removing the upper cover 10 according to an embodiment of the multifunctional reagent kit 100 of the present disclosure. Figure 2B for Figure 2A The multifunctional reagent kit 100 is shown as a schematic diagram after the upper two electrochemical test strips 22 and the remaining parts are exploded.

[0076] like Figure 2A and Figure 2B As shown, the test strip support 20 is provided with M' groups (such as Figure 2A and Figure 2B As shown, M' is 2) electrochemical test strip channels, each group of electrochemical test strip channels includes M" (such as Figure 2A and Figure 2B As shown, M" is 2) layers of electrochemical test strip channels 21 stacked and arranged in a staggered manner, and an electrochemical sample addition guide groove 211 is provided at one end of each electrochemical test strip channel 21. Among them, the electrochemical sample addition guide groove 211 of the lower electrochemical test strip channel 21 in two adjacent layers is exposed from the electrochemical sample addition guide groove 211 of the upper electrochemical test strip channel 21, so that the electrochemical sample addition guide groove 211 of each electrochemical test strip channel 21 can be added through the electrochemical test strip sample addition hole 11 of the upper cover 10.

[0077] Each electrochemical test strip channel 21 is attached with an electrochemical test strip 22. For example, the electrochemical test strip 22 can be attached to the upper surface or the lower surface of the electrochemical test strip channel 21. The front end (or reaction end) 221 of the electrochemical test strip 22 is close to the electrochemical sample addition flow guide groove 211 of the electrochemical test strip channel 21, and the rear end (or pin end) 222 of the electrochemical test strip 22 is away from the electrochemical sample addition flow guide groove 211 of the electrochemical test strip channel 21. When a liquid sample (for example, blood) enters the electrochemical loading guide groove 211 of the electrochemical test strip channel 21 through the electrochemical test strip loading hole 11 of the upper cover 10, since the front end (or reaction end) 221 of the electrochemical test strip 22 is close to the electrochemical loading guide groove 211 of the electrochemical test strip channel 21, and since the front end (or reaction end) 221 of the electrochemical test strip 22 contacts the blood, the blood reaches the rear end (or pin end) 222 of the electrochemical test strip 22 through siphoning, and then the electrochemical detection module can perform microcurrent detection on the rear end (or pin end) 222 of the electrochemical test strip 22, and then convert the microcurrent data into a specific electrochemical concentration value (for example, blood sugar value, blood ketone value or uric acid value). Optionally, in order to save space, starting from the topmost electrochemical test strip channel 21, in every two adjacent electrochemical test strip channels 21, the upper surface of the upper electrochemical test strip channel 21 is pasted with an electrochemical test strip 22, and the lower surface of the lower electrochemical test strip channel 21 is pasted with an electrochemical test strip 22. In this way, electrochemical detection modules can be respectively arranged above the upper electrochemical test strip channel 21 and below the lower electrochemical test strip channel 21 to perform microcurrent detection on the rear end (or pin end) 222 of the electrochemical test strips 22 arranged in the upper and lower layers, and then obtain the electrochemical concentration values ​​(for example, blood sugar value, blood ketone value or uric acid value) corresponding to the electrochemical test strips 22 arranged in the upper and lower layers. Figure 2A and Figure 2B Only two adjacent layers of electrochemical test strip channels 21 are shown. It is understandable that multiple two-layer electrochemical test strip channels 21 can be provided according to actual needs. Figure 2A and Figure 2B Only two groups of electrochemical test strip channels arranged side by side are shown, and one group, three groups or more groups of electrochemical test strip channels can also be arranged according to actual needs.

[0078] Alternatively, if Figure 2B and Figure 2C As shown, Figure 2C for Figure 2BThe multifunctional reagent kit 100 is shown as a schematic diagram after the test strip support 20 and the box body 30 are exploded. An anti-siphon groove 212 can be provided on the electrochemical test strip channel 21 between the electrochemical sample loading flow guide groove 211 and the end of the electrochemical test strip channel 21 away from the electrochemical sample loading flow guide groove 211, so that after the sample to be tested enters the electrochemical sample loading flow guide groove 211 through the electrochemical loading hole 11, since the sample to be tested (for example, blood) is easily capillary siphoned in a very smooth structure and then flows to other places, the anti-siphon groove 212 can cut off the sample to be tested from entering the area outside the electrochemical test strip channel 21 due to capillary siphoning, thereby ensuring that the sample to be tested can reach the reaction end 221 of the electrochemical test strip 22, and finally achieve electrochemical detection through the pin 222 end.

[0079] N dry chemical test strips may be disposed in the test strip support 20 or the sample adding and testing area 32 of the box body 30 .

[0080] Please refer to Figure 2A , Figure 2B and Figure 2C .like Figure 2A , Figure 2B and Figure 2C As shown, the sample addition detection area 32 of the box body 30 is provided with N dry chemical test strips 321. For example, the N dry chemical test strips 321 can be arranged end to end along a first direction (i.e., the extension direction of the dry chemical test strips 321), or can be arranged side by side along a second direction (i.e., a second direction perpendicular to the first direction), or can be arranged in an array along the first direction and the second direction. Figure 2C As shown, two dry chemical test strips 321 are connected end to end and extend along a first direction. Each dry chemical test strip 321 is provided with a dry chemical sample addition area 3211 .

[0081] The sample adding detection area 32 of the box body 30 or the test strip support 20 is provided with a dry chemical sample adding flow guide groove overlapping with the dry chemical sample adding area 3211 of each dry chemical test strip 321 in the horizontal projection direction.

[0082] Alternatively, if Figure 2C As shown, the dry chemical sample addition guide hole 23 can be set between the two groups of electrochemical test strip channels 21. The dry chemical sample addition guide hole 23 passes through the upper and lower surfaces of the test strip support 20, so that the dry chemical test strip 321 below can be added with the dry chemical sample addition guide hole 23, and the dry chemical sample addition guide hole 23 and the two groups of electrochemical test strip channels 21 can be integrated into a design to avoid the loss of the sample to be tested.

[0083] In some optional embodiments, such as Figure 2A , 2BAs shown in FIG. 2C , the middle part of the test strip support 20, i.e., the part between the two groups of electrochemical test strip channels, is a protruding compression strip 24 protruding downward, and the dry chemical sample addition flow guide hole 23 is arranged in the protruding compression strip 24 to save space. Here, the dry chemical sample addition flow guide hole 23 runs through the upper and lower surfaces of the protruding compression strip 24.

[0084] In addition, since the dry chemical test strip loading hole 12 of the upper cover 10 overlaps with the dry chemical loading area 3211 of each dry chemical test strip 321 in the horizontal projection direction, that is to say, the dry chemical loading guide holes 23 and the dry chemical loading area 3211 of the dry chemical test strip 321 are sequentially arranged below the dry chemical test strip loading hole 12 of the upper cover 10, which overlap in the horizontal projection direction. In this way, it is possible to load samples to the dry chemical loading area 3211 of the corresponding dry chemical test strip 321 through the dry chemical loading guide holes 23 through the dry chemical loading hole 12 of the upper cover 10.

[0085] It should be noted that at least one reaction area can be set on each dry chemical test strip 321, and each reaction area can correspond to a different test item. Optionally, the dry chemical sample loading area 3211 can be set at the center of the extension direction of the dry chemical test strip 321, so that the sample to be tested can flow evenly from the central dry chemical sample loading area 3211 of the dry chemical test strip 321 to other reaction areas. By setting a reaction layer with different functions for each reaction area, a specific reaction is performed for the biochemical characteristics of different test items (for example, cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG)), and then the reflection intensity is measured by using a photoelectric detection module for different reaction areas of the dry chemical test strip 321, and photoelectric conversion is performed to obtain a photoelectric conversion result, and then the photoelectric conversion result is calculated to obtain the corresponding dry chemical test result (for example, different blood lipid concentration indicators, such as total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) concentration).

[0086] The sample addition detection area 32 of the box body 30 is also provided with dry chemical detection holes 322 corresponding to each reaction area on each dry chemical test strip 321. Through the dry chemical detection holes 322, photoelectric detection of the corresponding reaction area on the dry chemical test strip 321 can be achieved. Figure 2D , Figure 2D yes Figure 2C The schematic diagram of the multifunctional reagent kit 100 after the dry chemical test strip 321 is exploded from the box body 30 is shown. Figure 2D As shown, the dry chemical detection hole 322 can be arranged below the corresponding dry chemical test strip 321 .

[0087] Optionally, refer to Figure 2E , Figure 2E yes Figure 2DThe multifunctional reagent kit 100 shown is a three-dimensional schematic diagram observed from a lower perspective. Figure 2E As shown, the sample loading and detection area 32 of the box body 30 also includes a positioning guide plate 323, which is used to position and guide the box body 30 of the multifunctional reagent kit 100. Specifically, at least one (for example, 4) positioning guide springs 3231 are arranged around the positioning guide plate 323. When the multifunctional reagent kit 100 is assembled into the guide groove in the detection instrument, the positioning guide springs 3231 can adaptively limit the overall movement of the multifunctional reagent kit 100 in the up, down, left and right directions, and eliminate the gap in these two directions, so as to achieve that the electrochemical test strip 22 and the dry chemical test strip 321 can fit the corresponding parts of the test strip support 20 and the box body 30 in the multifunctional reagent kit 100 without gaps, so that the detection result is more stable.

[0088] Optionally, the dry chemical detection hole 322 can be arranged inside the positioning guide plate 323 of the multifunctional reagent kit 100, which can further save space.

[0089] Optionally, the dry chemical test strip 321 is arranged between the protruding pressing strip 24 and the positioning guide plate 323, and the protruding pressing strip 24 is fixed to the positioning guide plate 323 by a positioning element (for example, a positioning pin). In this way, the dry chemical test strip 321 can be precisely limited and fixed, and the dry chemical test strip 321 can be compressed, thereby making it easy for the sample to be tested to diffuse on the dry chemical test strip 321.

[0090] In some optional implementations, please refer to Figure 3 , Figure 3 FIG. 4 is a perspective schematic diagram of the sample tube 40, the detection circuit board 50, the TIP head 60 and the multifunctional reagent kit 100 after being assembled according to the present disclosure. Figure 3 As shown, first, the sealed tube cover of the sample tube 40 is installed downwardly in the sample tube installation groove 311. After installation, the sample tube 40 is in sealed contact with the sample tube installation groove 311. Subsequently, the TIP head 60 can be grabbed from the TIP head grabbing groove 313, and samples can be taken through the sampling groove 312. Then, the electrochemical test strip sample loading hole 11 or the dry chemical test strip sample loading hole 12 can be entered through the TIP head 60 to achieve sample loading of the electrochemical test strip 22 or the dry chemical test strip 321. The detection circuit board 50 is inserted into the box body 30, and then the electrochemical test strip 22 can be electrochemically detected, or the dry chemical test strip 321 can be photoelectrically detected.

[0091] In some optional implementations, please refer to Figure 4A , Figure 4B , Figure 4C and Figure 4D , Figure 4A and Figure 4B are three-dimensional schematic diagrams of an embodiment of a sample tube 40 according to the present disclosure in an upright state and an inverted state, respectively. Figure 4C and Figure 4D Exploded views of an embodiment of a sample tube 40 according to the present disclosure in an upright state and an inverted state, respectively.

[0092] like Figure 4A , Figure 4B , Figure 4C and Figure 4D As shown, the sample tube 40 includes a tube body 41 and a sealing tube cover 42 .

[0093] Please refer to Figure 4E , Figure 4E FIG. 4 is a perspective schematic diagram of the sealing tube cover 42 according to the present disclosure in an upright state. Figure 4E As shown, a rubber stopper 421 is provided at one end of the sealing tube cover 42 away from the tube body 41. The rubber stopper 421 is used to seal the sample to be tested in the sample tube 40, and when the rubber stopper 421 is broken by the guide barrel 3111 of the sample tube mounting groove 311, the sample to be tested is guided into the sample tube mounting groove 311 and forms a sealed contact with the sample tube mounting groove 311.

[0094] Alternatively, if Figure 4A , Figure 4B and Figure 4C As shown, the end face of the sealing tube cover 42 is provided with a breathable groove 422, and the breathable groove 422 runs through the inner wall and the outer wall of the sealing tube cover 42, and is used to form an atmosphere-accessible passage in the sample tube 40 through the breathable groove 422 when the sample tube 40 is installed in the sample installation groove 311 and the sample to be tested in the sample tube 40 is sucked by negative pressure.

[0095] Optionally, a filter net may be provided on the rubber stopper 421 to filter the liquid flowing from the sample tube 40 into the sample tube mounting groove 311 to ensure the quality of the filtered sample.

[0096] Optionally, a small circular hole 4211 is provided in the rubber stopper 421 for guiding the sample to be tested in the sample tube 40 to the flow channel below and then flowing into the sample tube installation groove 311 .

[0097] Optionally, the small circle hole 4211 of the rubber stopper 421 of the sealing tube cover 42 can be set to an inner hollow cone surface, and the blood connection is set to a round hole or a "cross" groove. When the sample tube 40 is inverted and installed in the sample tube mounting groove 311, a sealing structure is formed between the rubber stopper 421 of the sealing tube cover 42 and the guide barrel 3111 of the sample tube mounting groove 311, thereby preventing the sample to be tested in the sample tube 40 from flowing out and avoiding liquid leakage. Finally, by sucking the sample from the sampling groove 312, the round hole or cross groove can be broken under the action of the above-mentioned suction pressure to form a suction channel.

[0098] Optionally, refer to Figure 1A , Figure 5 and Figure 6 , Figure 5 FIG. 3 is a cross-sectional view of a sample tube mounting groove 311, a U-shaped flow channel 315, and a sample tube 40 in one embodiment of a multifunctional reagent kit 100 according to the present disclosure. Figure 6 FIG. 1 is a cross-sectional view of a multifunctional reagent box sampling slot 312, a TIP head grabbing slot 313, and a U-shaped flow channel 315 in a sampling area 31 in one embodiment of a multifunctional reagent box 100 according to the present disclosure. Figure 1A , Figure 5 and Figure 6 As shown, the sample tube installation slot 311 is in flow communication with the sampling slot 312 through the U-shaped flow channel 315. The U-shaped flow channel 315 includes a first flow channel 3151, a second flow channel 3152, a third flow channel 3153, a fourth flow channel 3154 and a fifth flow channel 3155 connected in sequence. Among them, the first flow channel 3151 is parallel to the extension direction of the guide barrel 3111, and the first flow channel 3151 is used to connect the guide barrel 3111 of the sample tube installation slot 311 and the second flow channel 3152, the second flow channel 3152 is perpendicular to the extension direction of the electrochemical test strip channel 21 and the extension direction of the guide barrel 3111, the third flow channel 3153 is parallel to the extension direction of the electrochemical test strip channel 21, the fourth flow channel 3154 is parallel to the extension direction of the guide barrel 3111, the fifth flow channel 3155 is parallel to the second flow channel 3152, and the fifth flow channel 3155 is used to connect the sampling slot 312 and the fourth flow channel 3154. This is in consideration of the manufacturing process of the parts. The use of a U-shaped flow channel can simplify the manufacturing complexity of the multifunctional reagent kit. Optionally, the bends of the U-shaped flow channel 315, i.e., the junctions of the first flow channel 3151 and the second flow channel 3152, the junctions of the second flow channel 3152 and the third flow channel 3153, the junctions of the third flow channel 3153 and the fourth flow channel 3154, and the junctions of the fourth flow channel 3154 and the fifth flow channel 3155, can be ultrasonically welded to form a sealing structure to improve the sealing performance of the U-shaped flow channel 315. Figure 1A The direction indicated by the dotted arrow is the flow direction of the sample to be tested.

[0099] Specifically, if Figure 1Aand Figure 1B As shown, the sample tube installation groove 311 can be a groove of various shapes, and a guide barrel 3111 can be provided in the sample tube installation groove 311. The guide barrel 3111 can be provided with a sample guide hole 3112 that penetrates the upper and lower surfaces of the guide barrel 3111. The sample guide hole 3112 connects the pipeline (for example, U-shaped flow channel 315) between the sample tube installation groove 311 and the sampling groove 312. The outer wall of the guide barrel 3111 can be connected to the sealing tube cover 42 (such as the sealing tube cover 42 of the sample tube 40) Figure 4A , Figure 4B , Figure 4C and Figure 4E An oblique cone seal is formed between the sealing tube cover 42 of the sample tube 40 at one end away from the tube body 41 and a rubber stopper 421 is provided, and the inner wall of the sealing tube cover 42 of the sample tube 40 at one end away from the tube body 41 is completely matched with the outer wall of the guide barrel 3111. When the sample tube 40 is inverted in the sample tube mounting groove 311, the guide barrel 3111 can pierce the middle part of the rubber stopper 421 provided at one end of the sealing tube cover 42 of the sample tube 40 away from the tube body 41, and an oblique cone seal structure can be formed between the guide barrel 3111 and the rubber stopper 421. When no negative pressure is generated, the sample to be tested remains in the sample tube 40; when negative pressure is generated in the sample tube 40 and the sample tube mounting groove 311 (for example, negative pressure from the sampling groove 312), the sample to be tested can flow from the sample tube 40 into the sample tube mounting groove 311, for example, into the sample guide hole 3112, and enter the sampling groove 312 through the U-shaped flow channel 315, and then the sample to be tested can be sucked from the sampling groove 312. As an example, the guide barrel 3111 can be a hollow truncated cone.

[0100] In some optional implementations, please refer to Fig. 7A and Figure 7B , Fig. 7A and Figure 7B They are respectively an upper view and a lower view of an embodiment of the sampling area 31 in the multifunctional reagent kit 100 according to the present disclosure. Fig. 7A and Figure 7B As shown, three centering spring pieces 3131 are arranged in the TIP head grabbing groove 313 to limit and fix the TIP head. That is, the TIP head is held by the three centering spring pieces 3131 to prevent the TIP head from falling out of the TIP head grabbing groove 313.

[0101] In some optional embodiments, continue to refer to Fig. 7A and Figure 7B ,like Fig. 7A and Figure 7B As shown, two reminder springs 3113 are provided in the sample tube installation slot 311, which are used to remind the user that the sample tube 40 is installed in place when the sample tube 40 is installed in place. For example, the user is reminded that the sample tube 40 is installed in place by means of sound or force change.

[0102] In some optional embodiments, the sample tube mounting groove 311 can be in sealing contact with the sample tube 40 through an inclined cone surface, and the inclined cone surface can pierce the middle of the rubber stopper 421 set at one end of the sealing tube cover 42 of the sample tube 40 away from the tube body 41.

[0103] The following describes how to use Figure 1A , Figure 1B The multifunctional reagent kit 100 is shown to perform a detection work process.

[0104] The first step is to prepare a sample tube 40.

[0105] Here, the sample tube 40 contains a sample to be tested, such as a blood sample.

[0106] In the second step, the sealed tube cover 42 of the sample tube 40 is installed downward on the sample tube installation groove 311 of the multifunctional reagent kit 100.

[0107] Optionally, a prompt spring piece 3113 is provided in the sample tube installation groove 311 , and the sound or force change emitted by the prompt spring piece 3113 can be used to confirm that the sample tube 40 is installed in place.

[0108] During the process of installing the sample tube 40 into the sample tube mounting groove 311, the sample tube mounting groove 311 will pierce the middle part of the sealing tube cover 42 of the sample tube 40, for example, by piercing the middle part of the sealing tube cover 42 of the sample tube 40 through the oblique cone surface of the outer wall of the guide barrel 3111. However, since the sample tube 40 is provided with a breathable groove 422, the sample tube 40 is connected to the atmosphere. Therefore, after the sample tube 40 is inverted, the sample to be tested will still remain in the sample tube 40 when no negative pressure is generated.

[0109] In the third step, negative pressure is applied to the sampling groove 312 so that the sample to be tested flows from the sample tube 40 into the sampling groove 312 .

[0110] Use a pipette gun or an automatic sample loading module device to apply negative pressure to the sample sampling slot 312 .

[0111] In this way, the sample to be tested can flow from the sample tube 40 into the sample tube installation groove 311 , for example, into the sample guide hole 3112 , and enter the sampling groove 312 through the U-shaped flow channel 315 .

[0112] The fourth step is to grab the TIP head from the TIP head grabbing slot 313, use the grabbed TIP head to absorb the sample to be tested from the sampling slot 312 and add the sample to the M electrochemical test strip sample adding holes 11 and / or the N dry chemical test strip sample adding holes 12, and then release the TIP head to the TIP head discarding slot 314.

[0113] The sampling and sample addition operations can be completed through the first to sixth steps. Subsequently, the corresponding test items can be tested by testing M electrochemical test strips and / or N dry chemical test strips.

[0114] The flow chart and block diagram in the accompanying drawings illustrate the possible architecture, function and operation of the system, method and computer program product according to various embodiments of the present disclosure. In this regard, each square box in the flow chart or block diagram can represent a module, a program segment or a part of a code, and the module, the program segment or a part of the code contains one or more executable instructions for realizing the specified logical function. It should also be noted that in some implementations as replacements, the functions marked in the square box can also occur in a sequence different from that marked in the accompanying drawings. For example, two square boxes represented in succession can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each square box in the block diagram and / or flow chart, and the combination of the square boxes in the block diagram and / or flow chart can be implemented with a dedicated hardware-based system that performs a specified function or operation, or can be implemented with a combination of dedicated hardware and computer instructions.

[0115] The units or modules involved in the embodiments described in the present disclosure may be implemented by software or hardware, wherein the name of a unit or module does not, in some cases, limit the unit or module itself.

[0116] The above description is only a preferred embodiment of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of disclosure involved in the present disclosure is not limited to the technical solutions formed by a specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the above disclosed concept. For example, the above features are replaced with the technical features with similar functions disclosed in the present disclosure (but not limited to) by each other to form a technical solution.

Claims

1. A multifunctional kit comprising: An upper cover (10), a test strip support (20) and a box body (30) are sequentially arranged from top to bottom, and M electrochemical test strips and N dry chemical test strips are arranged between the upper cover (10) and the box body (30); The upper cover (10) is provided with M electrochemical test strip sample loading holes (11) and N dry chemical test strip sample loading holes (12), and the M electrochemical test strip sample loading holes (11) and the N dry chemical test strip sample loading holes (12) both penetrate the upper and lower surfaces of the upper cover (10); The box body (30) comprises a sampling area (31) and a sample adding and testing area (32); the sampling area (31) is provided with a sample tube installation slot (311), a sampling slot (312), a TIP head grabbing slot (313) and a TIP head discarding slot (314); The sample tube installation groove (311) is used to support the sample tube (40) and communicate with the sample tube (40), and a flow channel is connected between the sample tube installation groove (311) and the sampling groove (312); The test strip support (20) is arranged above the sample adding detection area (32), and the test strip support (20) cooperates with the sample adding detection area (32) to fix and support the M chemical test strips and the N dry chemical test strips.

2. The multifunctional kit according to claim 1, wherein The M electrochemical test strips and the N dry chemical test strips are arranged in the sample adding and detecting area (32); preferably, the test strip support (20) is arranged above the sample adding and detecting area (32).

3. The multifunctional kit according to claim 1, wherein The sample tube installation groove (311) is connected to the sampling groove (312) via a U-shaped flow channel (315); preferably, the bending part of the U-shaped flow channel (315) is ultrasonically welded to form a sealing structure.

4. The multifunctional kit according to claim 1, wherein The sample tube installation groove (311) is in sealing contact with the sample tube (40) via an inclined conical surface, and the inclined conical surface can pierce the middle of the sealed tube cover of the sample tube (40).

5. The multifunctional kit according to claim 1, wherein Three centering spring pieces (3131) are arranged in the TIP head grabbing groove (313) for limiting and fixing the TIP head; preferably, two prompt spring pieces (3113) are arranged in the sample tube installation groove (311) for prompting the sample tube (40) to be installed in place when the sample tube (40) is installed in place.

6. The multifunctional kit according to claim 1, wherein The M electrochemical test strip sample loading holes (11) and the N dry chemical test strip sample loading holes (12) are inverted frustums with hollow interiors.

7. The multifunctional kit according to claim 1, wherein The horizontal projections of the sample adding areas of the M electrochemical test strips and the sample adding areas of the N dry chemical test strips do not overlap; Preferably, the test strip support (20) is provided with M electrochemical test strip channels (21) stacked in a staggered manner, one end of the electrochemical test strip channel (21) is provided with an electrochemical sample addition flow guide groove (211), and the electrochemical sample addition flow guide groove (211) of the lower electrochemical test strip channel (21) of two adjacent layers is exposed from the electrochemical sample addition flow guide groove (211) of the upper electrochemical test strip channel (21); Preferably, the sample adding and testing area (32) further comprises a positioning guide plate (323) for positioning and guiding the box body (30) of the multifunctional reagent box; Preferably, the positioning guide plate (323) is provided with N dry chemical detection holes (322), and the dry chemical detection holes (322) are arranged below the corresponding dry chemical test strips (321); Preferably, the test strip support (20) is provided with a protruding pressing strip (24) protruding downward, and the protruding pressing strip (24) is provided with N dry chemical sample addition flow guide holes (23), and the dry chemical sample addition flow guide holes (23) penetrate the upper and lower surfaces of the protruding pressing strip (24); Preferably, the protruding pressing strip (24) is fixed on the positioning guide plate (323) via a positioning element, and the N dry chemical test strips (321) are arranged between the protruding pressing strip (24) and the positioning guide plate (323).

8. The multifunctional kit according to claim 7, wherein An electrochemical test strip (22) is adhered to the upper surface or the lower surface of each electrochemical test strip channel (21).

9. The multifunctional kit according to claim 8, wherein The reaction end of each electrochemical test strip (22) is close to the electrochemical sample addition flow guide groove (211) of the corresponding electrochemical test strip channel (2) 1, and the pin end of each electrochemical test strip (22) is away from the electrochemical sample addition flow guide groove (211) of the corresponding electrochemical test strip channel (21).

10. The multifunctional kit according to claim 7, wherein The electrochemical test strip channel (21) is provided with an anti-siphon groove (212) between the electrochemical sample addition flow guide groove (211) and an end of the electrochemical test strip channel (21) away from the electrochemical sample addition flow guide groove (211).

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