Method, equipment and program product for identifying rare intestinal diseases

Abstract

The invention relates to the field of intelligent medical treatment, in particular to a method, equipment and a program product for identifying rare intestinal diseases. The method includes: acquiring pathological data of a to-be-tested person; the pathological data comprises goblet cells, panoptic cells, neutrophils and plasma cells; based on the pathological data, the types of rare intestinal diseases of the to-be-detected person are judged, wherein the types of the rare intestinal diseases comprise autoimmune bowel diseases and common variant immunological defect diseases; when the pathological data shows that goblet cells are smaller than a preset threshold value, panoptic cells are smaller than the preset threshold value, any two or more of neutrophil infiltration occurs, and plasma cells are unchanged, the autoimmune bowel disease is judged, and when the pathological data shows that the plasma cells are smaller than the preset threshold value, the common variant immunological defect disease is judged. The application can effectively distinguish the types of rare intestinal diseases, and has good clinical value.

Description

Technical Field

[0001] This application relates to the field of intelligent medicine, and specifically relates to a method, device, program product, and computer-readable storage medium for identifying rare intestinal diseases. Background Art

[0002] The rare intestinal disease autoimmune enteropathy AIE is extremely rare, with a global incidence rate of less than 1 / 100,000, and adult cases are even rarer. Currently, only more than 200 cases have been reported. Common variable immunodeficiency CVID belongs to primary immunodeficiency diseases, and patients with gastrointestinal involvement of CVID are also relatively rare. If either of them is misdiagnosed or missed diagnosed, it will lead to the delay of the patient's condition, the emergence of serious complications, affect the quality of life and even endanger life. The clinical manifestations of AIE and CVID overlap. In addition to having digestive tract symptoms such as diarrhea and malabsorption, both AIE and CVID may be accompanied by systemic manifestations such as fever and electrolyte disorders, and may also involve other systems. For example, CVID can present with recurrent infections and autoimmune diseases, and AIE may also have involvement of other organs related to autoimmunity. It is difficult to clearly distinguish them only from clinical features. Although there are indicators such as autoantibodies of intestinal epithelial cells in the diagnosis of AIE, the absence of antibodies does not rule out the disease. CVID is mainly based on the reduction of serum immunoglobulin levels, etc., but similar situations may also occur in other diseases. Currently, there is a lack of specific diagnostic indicators and diagnostic processes for AIE patients and CVID patients with gastrointestinal involvement respectively. Summary of the Invention

[0003] In view of the above problems, the present invention provides a method for identifying rare intestinal diseases, which specifically includes: Obtain the pathological data of the person to be tested; the pathological data includes goblet cells, Paneth cells, neutrophils, and plasma cells; Based on the pathological data, determine the type of rare intestinal disease of the person to be tested. The types of rare intestinal diseases include autoimmune enteropathy and common variable immunodeficiency disease; when any two or more of the pathological manifestations that the goblet cells are less than the preset threshold, the Paneth cells are less than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows that the plasma cells are less than the preset threshold, it is determined as common variable immunodeficiency disease.

[0004] Optionally, the pathological data is replaced by the immunoprotein expression level, and the type of rare intestinal disease is determined based on the immunoprotein expression level. The immunoprotein expression level includes one or more of the following: IgG, IgM, IgA; when the immunoprotein expression level is greater than the preset threshold, it is determined as autoimmune enteropathy, otherwise, it is determined as common variable immunodeficiency disease.

[0005] Optionally, the pathological data further includes the expression level of immune proteins. When the pathological data shows that any two or more of the goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of immune proteins is greater than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than a preset threshold and / or the expression level of immune proteins is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0006] The method further includes type classification. The tested person after classification is obtained by classifying the tested person; the type of rare intestinal disease of the classified tested person is judged.

[0007] The process of the type classification is as follows: Obtain the clinical data of the tested person; Based on the clinical data, judge whether there is a rare intestinal disease. When chronic diarrhea appears, it is determined as a suspected rare intestinal disease; otherwise, it is determined that other disease causes such as infection and immunity need to be further screened. Obtain the intestinal endoscopy data of the tested person determined to be a suspected rare intestinal disease. Based on the intestinal endoscopy data, judge whether it is intestinal disease with small intestinal villous atrophy. When the intestinal endoscopy shows small intestinal villous atrophy, it is determined as intestinal disease with small intestinal villous atrophy; otherwise, it is determined as other intestinal diseases. Obtain the pathological data of the tested person determined to be intestinal disease with small intestinal villous atrophy, and judge autoimmune enteropathy or common variable immunodeficiency disease based on the pathological data.

[0008] Optionally, the pathological data is four indicators of the duodenum. When any two or more of the goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0009] The pathological data is replaced by the expression level of IgG immunoglobulin. Autoimmune enteropathy or common variable immunodeficiency disease is judged through the expression level of IgG immunoglobulin. When the expression level of IgG immunoglobulin is greater than a preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0010] Optionally, the pathological data is replaced by the expression level of IgM immunoglobulin. Autoimmune enteropathy or common variable immunodeficiency disease is judged through the expression level of IgM immunoglobulin. When the expression level of IgM immunoglobulin is greater than a preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0011] Optionally, the pathological data is replaced with the expression level of IgA immunoglobulin. Autoimmune enteropathy or common variable immunodeficiency is determined based on the expression level of IgA immunoglobulin. When the expression level of IgA immunoglobulin is greater than the preset threshold, it is determined to be autoimmune enteropathy; otherwise, it is determined to be common variable immunodeficiency.

[0012] The determination of the autoimmune enteropathy or common variable immunodeficiency also includes the expression level of IgG immunoglobulin. When any two or more of the following occur: goblet cells are less than the preset threshold, Paneth cells are less than the preset threshold, the expression level of IgG immunoglobulin is greater than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data shows that the plasma cells are less than the preset threshold and / or the expression level of IgG immunoglobulin is less than the preset threshold, it is determined to be common variable immunodeficiency.

[0013] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency also includes the expression level of IgM immunoglobulin. When any two or more of the following occur: goblet cells are less than the preset threshold, Paneth cells are less than the preset threshold, the expression level of IgM immunoglobulin is greater than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data shows that the plasma cells are less than the preset threshold and / or the expression level of IgM immunoglobulin is less than the preset threshold, it is determined to be common variable immunodeficiency.

[0014] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency also includes the expression level of IgA immunoglobulin. When any two or more of the following occur: goblet cells are less than the preset threshold, Paneth cells are less than the preset threshold, the expression level of IgA immunoglobulin is greater than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data shows that the plasma cells are less than the preset threshold and / or the expression level of IgA immunoglobulin is less than the preset threshold, it is determined to be common variable immunodeficiency.

[0015] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency also includes the expression levels of IgM immunoglobulin and IgG immunoglobulin. When any two or more of the following occur: goblet cells are less than the preset threshold, Paneth cells are less than the preset threshold, the expression level of IgM immunoglobulin is greater than the preset threshold, the expression level of IgG immunoglobulin is greater than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data shows any one or more of the following: plasma cells are less than the preset threshold, the expression level of IgM immunoglobulin is less than the preset threshold, and the expression level of IgG immunoglobulin is less than the preset threshold, it is determined to be common variable immunodeficiency.

[0016] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression levels of IgA immunoglobulin and IgG immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, and neutrophil infiltration is present, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgA immunoglobulin is less than a preset threshold, and the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0017] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression levels of IgA immunoglobulin and IgM immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, and neutrophil infiltration is present, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgM immunoglobulin is less than a preset threshold, and the expression level of IgA immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0018] Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression levels of IgA immunoglobulin, IgM immunoglobulin, and IgG immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, and neutrophil infiltration is present, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgA immunoglobulin is less than a preset threshold, the expression level of IgM immunoglobulin is less than a preset threshold, and the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0019] The pathological data is replaced by the second intestinal endoscopy data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined through the second intestinal endoscopy data. When duodenal erosion and / or congestion occur, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0020] Optionally, the determination of autoimmune enteropathy or common variable immunodeficiency disease further includes second intestinal endoscopy data. Autoimmune enteropathy or common variable immunodeficiency disease is determined based on the pathological data and the second intestinal endoscopy data. When any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, neutrophil infiltration appears, duodenal erosion and / or congestion, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the duodenum is normal, it is determined as common variable immunodeficiency disease.

[0021] Replace the pathological data with second clinical data. Autoimmune enteropathy or common variable immunodeficiency disease is determined based on the second clinical data. When the duration of chronic diarrhea is less than a preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0022] Optionally, replace the duration of chronic diarrhea with recurrent respiratory tract infections. When recurrent respiratory tract infections occur, it is determined as common variable immunodeficiency disease; otherwise, it is determined as autoimmune enteropathy.

[0023] Optionally, the determination of autoimmune enteropathy or common variable immunodeficiency disease further includes second clinical data. Autoimmune enteropathy or common variable immunodeficiency disease is determined based on the pathological data and the second clinical data. When any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, neutrophil infiltration appears, the duration of chronic diarrhea is less than a preset threshold, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the duration of chronic diarrhea is greater than a preset threshold, it is determined as common variable immunodeficiency disease.

[0024] The object of the present invention is to provide a computer program product, which includes a computer program or instruction. The computer program or instruction is executed by a processor to implement the above method for identifying rare intestinal diseases.

[0025] The object of the present invention is to provide a computer device, which includes a memory, a processor, and a computer program or instruction stored on the memory. The computer program or instruction is executed by the processor to implement the above method for identifying rare intestinal diseases.

[0026] The object of the present invention is to provide a computer-readable storage medium, on which a computer program or instruction is stored. The computer program or instruction is executed by a processor to implement the above method for identifying rare intestinal diseases.

[0027] Advantages of the present invention: 1. Patients with gastrointestinal involvement in autoimmune enteropathy (AIE) and common variable immunodeficiency (CVID) can both present with chronic diarrhea, and both endoscopy and histopathology show villous atrophy in the small intestine. The differential diagnosis between the two is still difficult. The present invention analyzes from three dimensions: clinical characteristics, endoscopic characteristics, and pathological characteristics, and proposes a judgment process for differentiating AIE and CVID to improve the efficiency and accuracy of clinical diagnosis.

[0028] 2. The identification process for AIE and CVID first divides patients through the clinical characteristics of chronic diarrhea and intestinal endoscopic data of villous atrophy in the small intestine, and then detects four pathological indicators of the duodenum in the divided patients. When two or more of the three characteristics of goblet cell reduction, Paneth cell reduction, and neutrophil infiltration are present and there is no plasma cell reduction, it is determined as AIE; when plasma cell reduction is present, it is determined as CVID; it can effectively distinguish intestinal rare diseases in the divided patients and is helpful for clinical diagnosis.

[0029] 3. For the divided patients, the present invention also proposes differentiation indicators for the duration of chronic diarrhea, recurrent respiratory tract infections, the expression levels of IgG, IgM, and IgA immunoglobulins, and endoscopic duodenal erosion and / or congestion, providing more differentiation indicators to improve the accuracy and reliability of differentiating AIE and CVID. Description of the Drawings

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those skilled in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0031] Figure 1 It is a schematic flow chart of the method for identifying intestinal rare diseases provided by the embodiment of the present invention; Figure 2 It is a schematic diagram of the system for identifying intestinal rare diseases provided by the embodiment of the present invention; Figure 3 It is a schematic diagram of the device for identifying intestinal rare diseases provided by the embodiment of the present invention; Figure 4 It is the diarrhea course characteristics of patients with autoimmune enteropathy and common variable immunodeficiency with gastrointestinal involvement provided by the embodiment of the present invention. A: The distribution characteristics of the diarrhea course of AIE and CVID patients, and the red line represents the median; B: The receiver operating characteristic (ROC) curve of the diarrhea course (months).

[0032] Figure 5Immunological characteristics of patients with autoimmune enteropathy and common variable immunodeficiency with gastrointestinal involvement provided by the embodiments of the present invention: levels of complement C3 (A) and immunoglobulins IgG (B), IgA (C), and IgM (D), with the red line indicating the median. E: Receiver operating characteristic (ROC) curves of IgG, IgA, and IgM; Figure 6 Pathological characteristic manifestations of patients with autoimmune enteropathy (AIE) and common variable immunodeficiency with gastrointestinal involvement (CVID) provided by the embodiments of the present invention. A: Shortened small intestinal villi and lack of plasma cells in CVID patients (40×, hematoxylin and eosin staining). B: Lymphocytosis in CVID patients with normal goblet cells (200×, hematoxylin and eosin staining). C: Lack of plasma cells in the lamina propria of CVID patients (100×, CD138 immunohistochemical staining). D: Shortened villi in AIE patients (40×, hematoxylin and eosin staining). E: Neutrophil infiltration, lymphocytosis, and loss of goblet cells and Paneth cells in AIE patients (200×, hematoxylin and eosin staining). F: Apoptotic bodies (arrows) in AIE patients (200×, hematoxylin and eosin staining).

[0033] Figure 7 Kaplan-Meier recurrence-free survival curves provided by the embodiments of the present invention: A is for common variable immunodeficiency disease; B is for autoimmune enteropathy; C is for comparison between patients with autoimmune enteropathy and common variable immunodeficiency disease. Detailed implementation manners

[0034] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0035] In some processes described in the specification, claims, and above-mentioned drawings of the present invention, a plurality of operations appear in a specific order. However, it should be clearly understood that these operations may not be executed in the order in which they appear herein or may be executed in parallel. The serial numbers of the operations, such as S101, S102, etc., are only used to distinguish different operations, and the serial numbers themselves do not represent any execution order. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions such as "first" and "second" in this article are used to distinguish different messages, devices, modules, etc., and do not represent a sequence, nor do they limit that "first" and "second" are of different types.

[0036] Figure 1 Schematic diagram of the method for identifying rare intestinal diseases provided by the embodiments of the present invention, specifically including: S101: Obtain the pathological data of the person to be tested; the pathological data includes goblet cells, Paneth cells, neutrophils, and plasma cells; The pathological data are four indicators of the duodenum, comprehensively considering the abnormalities of epithelial cell subsets and immune cell subsets.

[0037] In a specific embodiment, patients diagnosed with AIE and patients with gastrointestinal involvement in CVID who were hospitalized and treated in Peking Union Medical College Hospital from June 2012 to May 2024 were retrospectively included. The latter had digestive tract symptoms and evidence of gastrointestinal involvement confirmed by digestive endoscopy. Demographic characteristics, symptoms, past medical history, auxiliary examinations, endoscopic and histopathological characteristics, and long-term prognosis information of the two groups of patients were collected. The differences between the two groups of patients were compared by chi-square test, Fisher's exact test, Student's t test, and Wilcoxon rank-sum test. The sensitivity and specificity of diagnosing AIE and CVID based on four pathological indicators were calculated. The cut-off values and areas under the curve (AUC) of the diagnostic indicators (immunoglobulin levels and diarrhea duration) were calculated based on the ROC curve. Finally, the Kaplan-Meier survival curves of disease recurrence in the two groups of patients were plotted and the log-rank test was performed.

[0038] S102: Judge the type of rare intestinal disease of the person to be tested based on the pathological data. The types of rare intestinal diseases include autoimmune enteropathy and common variable immunodeficiency disease; when any two or more of the pathological manifestations show that the goblet cells are less than the preset threshold, the Paneth cells are less than the preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than the preset threshold, it is determined as common variable immunodeficiency disease.

[0039] In one embodiment, the preset threshold is the value of each type of cell in a healthy state.

[0040] In one embodiment, the neutrophil infiltration is replaced by the immunoprotein expression level. The type of rare intestinal disease is judged based on the immunoprotein expression level. The immunoprotein expression level includes one or more of the following: IgG, IgM, IgA; when the immunoprotein expression level is greater than the preset threshold, it is determined as autoimmune enteropathy, otherwise, it is determined as common variable immunodeficiency disease.

[0041] In one embodiment, the method further includes type division. The person to be tested is divided into a divided person to be tested; the type of rare intestinal disease of the divided person to be tested is judged.

[0042] In one embodiment, the process of the type division is as follows: Obtain the clinical data of the subject to be tested; based on the clinical data, determine whether there is a rare intestinal disease. When chronic diarrhea occurs, it is determined as "suspected rare intestinal disease"; otherwise, it is determined as "further screen for the causes of other diseases such as infection and immunity". Obtain the intestinal endoscopy data of the subject to be tested who is determined to have a suspected rare intestinal disease. Based on the intestinal endoscopy data, determine whether it is small intestinal villous atrophy enteropathy. When the intestinal endoscopy shows small intestinal villous atrophy, it is determined as small intestinal villous atrophy enteropathy; otherwise, it is determined as other intestinal diseases. In one embodiment, the intestinal endoscopy data includes small intestinal villous atrophy or no small intestinal villous atrophy.

[0043] Sub-divide the population of subjects to be tested with suspected rare intestinal diseases. The sub-division is carried out by detecting the intestinal endoscopy data. When the intestinal endoscopy data shows small intestinal villous atrophy, it is divided into the type of small intestinal villous atrophy enteropathy; when the intestinal endoscopy data does not show small intestinal villous atrophy, it is divided into the type of other intestinal diseases.

[0044] Obtain the pathological data of the subject to be tested who is determined to have small intestinal villous atrophy enteropathy. Based on the pathological data, determine autoimmune enteropathy or common variable immunodeficiency disease.

[0045] The pathological data are four indicators of the duodenum. When any two or more of the following conditions occur: goblet cells are less than the preset threshold, Paneth cells are less than the preset threshold, and neutrophil infiltration appears, and plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than the preset threshold, it is determined as common variable immunodeficiency disease.

[0046] Identify AIE and CVID for the subjects with the type of small intestinal villous atrophy enteropathy. Determine whether it meets the four indicators through the pathological data performance, that is, when two or more of the three characteristics of goblet cell reduction, Paneth cell reduction, and neutrophil infiltration appear, and there is no plasma cell reduction, and when plasma cells are reduced, it is determined as CVID.

[0047] In one embodiment, the pathological data is replaced by the IgG immunoglobulin expression level. Determine autoimmune enteropathy or common variable immunodeficiency disease through the IgG immunoglobulin expression level. When the IgG immunoglobulin expression level is greater than the preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0048] In one embodiment, the pathological data is replaced by the IgM immunoglobulin expression level. Determine autoimmune enteropathy or common variable immunodeficiency disease through the IgM immunoglobulin expression level. When the IgM immunoglobulin expression level is greater than the preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0049] In one embodiment, the pathological data is replaced by the expression level of IgA immunoglobulin. Autoimmune enteropathy or common variable immunodeficiency is judged based on the expression level of IgA immunoglobulin. When the expression level of IgA immunoglobulin is greater than a preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency.

[0050] In one embodiment, the judgment of the autoimmune enteropathy or common variable immunodeficiency further includes the expression level of IgG immunoglobulin. When any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, neutrophil infiltration appears, and plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency.

[0051] In one embodiment, the judgment of the autoimmune enteropathy or common variable immunodeficiency further includes the expression level of IgM immunoglobulin. When any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, neutrophil infiltration appears, and plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the expression level of IgM immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency.

[0052] In one embodiment, the judgment of the autoimmune enteropathy or common variable immunodeficiency further includes the expression level of IgA immunoglobulin. When any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, neutrophil infiltration appears, and plasma cells remain unchanged, it is determined as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the expression level of IgA immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency.

[0053] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression level of IgM immunoglobulin and the expression level of IgG immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgM immunoglobulin is less than a preset threshold, and the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0054] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression level of IgA immunoglobulin and the expression level of IgG immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgA immunoglobulin is less than a preset threshold, and the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0055] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression level of IgA immunoglobulin and the expression level of IgM immunoglobulin; when any two or more of the following conditions occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following conditions: plasma cells are less than a preset threshold, the expression level of IgM immunoglobulin is less than a preset threshold, and the expression level of IgA immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0056] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes the expression levels of IgA immunoglobulin, IgM immunoglobulin, and IgG immunoglobulin; when any two or more of the following occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, the expression level of IgA immunoglobulin is greater than a preset threshold, the expression level of IgM immunoglobulin is greater than a preset threshold, the expression level of IgG immunoglobulin is greater than a preset threshold, and neutrophil infiltration appears, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy; when the pathological data shows any one or more of the following: plasma cells are less than a preset threshold, the expression level of IgA immunoglobulin is less than a preset threshold, the expression level of IgM immunoglobulin is less than a preset threshold, and the expression level of IgG immunoglobulin is less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0057] In one embodiment, the pathological data is replaced with second intestinal endoscopy data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined through the second intestinal endoscopy data. When duodenal erosion and / or congestion appears, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0058] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes second intestinal endoscopy data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined through the pathological data and the second intestinal endoscopy data. When any two or more of the following occur: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, neutrophil infiltration appears, duodenal erosion and / or congestion appears, it is determined as autoimmune enteropathy; when the pathological data shows that plasma cells are less than a preset threshold and / or the duodenum is normal, it is determined as common variable immunodeficiency disease.

[0059] In one embodiment, the pathological data is replaced with second clinical data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined through the second clinical data. When the duration of chronic diarrhea is less than a preset threshold, it is determined as autoimmune enteropathy; otherwise, it is determined as common variable immunodeficiency disease.

[0060] In one embodiment, the duration of chronic diarrhea is replaced with recurrent respiratory tract infections. When recurrent respiratory tract infections occur, it is determined as common variable immunodeficiency disease; otherwise, it is determined as autoimmune enteropathy.

[0061] In one embodiment, the determination of the autoimmune enteropathy or common variable immunodeficiency disease further includes second clinical data. The autoimmune enteropathy or common variable immunodeficiency disease is determined based on the pathological data and the second clinical data. When any two or more of the following conditions occur: the goblet cells are less than a preset threshold, the Paneth cells are less than a preset threshold, neutrophil infiltration appears, and the duration of chronic diarrhea is less than a preset threshold, it is determined as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than a preset threshold and / or the duration of chronic diarrhea is greater than a preset threshold, it is determined as common variable immunodeficiency disease.

[0062] In one embodiment, in the method of undividing or dividing the subject to be tested, when identifying AIE and CVID, the discriminant indicators include: four duodenal pathological indicators (goblet cells, Paneth cells, neutrophils, plasma cells), the course of chronic diarrhea, recurrent respiratory tract infections, the expression levels of immunoglobulins (IgG, IgA, IgM), duodenal erosion, and congestion. AIE and CVID are identified through one or several discriminant indicators.

[0063] In a specific embodiment, a total of 26 patients with AIE and 29 patients with CVID with gastrointestinal involvement were included. Compared with patients with CVID with gastrointestinal involvement, patients with AIE had an older age at diagnosis, a shorter duration of chronic diarrhea, a larger diarrhea volume, and more obvious weight loss, hypoalbuminemia, and electrolyte disorders. In addition, patients with CVID with gastrointestinal involvement had a significant history of recurrent respiratory infections, significantly decreased levels of blood IgG, IgM, and IgA, a significantly reduced number of B cells in peripheral blood lymphocyte subsets, a reduced number of CD4+T cells, an increased number of CD8+T cells, and a significant inversion of CD4+ / CD8. The cut-off value of blood IgG level for differentiating these two types of diseases was 5.265 g / L (the reference range for the normal population was 7 - 17), and the AUC was 0.989. Endoscopically, the majority of patients had manifestations of small intestinal villous atrophy, and patients with AIE were more likely to present with endoscopic active inflammatory manifestations such as duodenal erosion and congestion. Further analysis of the histopathological features of 23 cases of AIE and 24 cases of CVID found that both had obvious shortening of small intestinal villi; compared with CVID, patients with AIE had a significant reduction or disappearance of goblet cells and Paneth cells, more obvious neutrophil infiltration, and more frequent apoptotic bodies; in patients with CVID, the lamina propria and deep crypts of intestinal biopsies showed a significant disappearance or reduction of plasma cells, and there was prominent lymphocyte infiltration in the deep crypts. In addition, most patients with CVID had the formation of lymphoid follicles. In patients with AIE and CVID with gastrointestinal involvement, the sensitivity of the four duodenal pathological indicators for differentiating AIE was 96%, and the specificity was 100%. Long-term follow-up showed that patients with both types of diseases were prone to recurrent diarrhea, and the median recurrence-free survival period of patients with CVID was slightly longer than that of AIE. Both patients with AIE and CVID with gastrointestinal involvement had small intestinal villous atrophy. Detailed medical history collection, targeted auxiliary examinations, high-quality endoscopic and histopathological feature descriptions provided strong evidence for the differential diagnosis of the two diseases.

[0064] In a specific embodiment, the present invention statistically analyzed the clinical features, endoscopic features, and pathological features of AIE and CVID, as shown in Tables 1, 2, and 3 respectively.

[0065] Table 1 Summary and comparison of clinical features of patients with autoimmune enteropathy and common variable immunodeficiency

[0066]

[0067] # Continuous variables that conform to the normal distribution are expressed as mean ± standard deviation, continuous variables that do not conform to the normal distribution are expressed as median (interquartile range IQR: 25th percentile - 75th percentile), and categorical variables are expressed as number (percentage).

[0068] $ The Student's t-test was used to evaluate the differences between two groups of continuous variables that conform to a normal distribution, and the Wilcoxon rank-sum test was used to evaluate the differences between two groups of continuous variables that do not conform to a normal distribution. The chi-square test or Fisher's exact test was used to analyze categorical variables.

[0069] Table 2 Summary and comparison of endoscopic features of patients with autoimmune enteropathy and common variable immunodeficiency

[0070] # Categorical variables are expressed as numbers (percentages).

[0071] $ The chi-square test or Fisher's exact test was used to analyze categorical variables.

[0072] Table 3 Summary and comparison of pathological features of patients with autoimmune enteropathy and common variable immunodeficiency

[0073] # Categorical variables are expressed as numbers (percentages).

[0074] $ The chi-square test or Fisher's exact test was used to analyze categorical variables.

[0075] % Marked intraepithelial lymphocytosis (IEL) was defined as more than 40 lymphocytes per 100 epithelial cells.

[0076] In a specific embodiment, the present invention performed statistical analysis on immunoglobulin levels, different pathological criteria, and single pathological feature diagnoses, as shown in Table 4.

[0077] Table 4 Calculation of diagnostic performance differences and optimal cut-off values for diagnosing patients with autoimmune enteropathy or common variable immunodeficiency with gastrointestinal involvement based on immunoglobulin levels and diarrhea duration using the receiver operating characteristic (ROC) curve

[0078]

[0079] The diarrhea duration of AIE and CVID is as Figure 4 , as shown in Table 4. The immunoglobulin manifestations of AIE and CVID are clearly divided, and the immunological results are as Figure 5 , as shown in Table 4. The pathological characteristic manifestations of AIE and CVID are as Figure 6As shown, the effects of four pathological features in differentiating two rare intestinal diseases are shown in Table 5. The recurrence-free survival curves of AIE and CVID are as Figure 7 shown.

[0080] Table 5 Sensitivity and specificity of four pathological criteria in differentiating AIE and CVID

[0081]

[0082] Sensitivity for diagnosing AIE = 22 / 23 = 96%;

[0083] Specificity for diagnosing AIE: 17 / 17 = 100%;

[0084] Sensitivity for diagnosing CVID = 17 / 17 = 100%;

[0085] Specificity for diagnosing CVID: 22 / 23 = 96%.

[0086] The disclosed embodiment of the present invention also provides a computer program product or system, including a computer program, which implements the method steps for identifying rare intestinal diseases as described above when executed by a processor.

[0087] Figure 2 The schematic diagram of the system for identifying rare intestinal diseases provided by the embodiment of the present invention specifically includes:

[0088] Acquisition module: acquiring the pathological data of the person to be tested; the pathological data includes goblet cells, Paneth cells, neutrophils, and plasma cells;

[0089] Discrimination module: judging the type of rare intestinal disease of the person to be tested based on the pathological data, and the type of rare intestinal disease includes autoimmune enteropathy and common variable immunodeficiency disease; when the pathological data shows any two or more of goblet cells less than a preset threshold, Paneth cells less than a preset threshold, and neutrophil infiltration, and the plasma cells remain unchanged, it is determined as autoimmune enteropathy, and when the pathological data shows plasma cells less than a preset threshold, it is determined as common variable immunodeficiency disease.

[0090] Figure 3 The schematic diagram of the device for identifying rare intestinal diseases provided by the embodiment of the present invention specifically includes:

[0091] A memory and a processor; the memory is used for storing program instructions; the processor is used for calling the program instructions to execute any one of the methods for identifying rare intestinal diseases as described above.

[0092] The disclosed embodiments of the present invention also provide a computer-readable storage medium storing a computer program, which, when executed by a processor, implements any of the above-described methods for identifying rare intestinal diseases.

[0093] The verification results of this verification embodiment show that assigning inherent weights to indications can improve the performance of this method compared to the default settings. Those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working processes of the systems, devices, and units described above can refer to the corresponding processes in the foregoing method embodiments and will not be elaborated herein. In several embodiments provided by the present application, it should be understood that the disclosed systems, devices, and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units is only a logical function division, and there can be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed couplings or direct couplings or communication connections to each other can be through some interfaces, and the indirect couplings or communication connections of the devices or units can be in electrical, mechanical, or other forms. The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment. In addition, in each embodiment of the present invention, the functional units can be integrated into one processing unit, or each unit can exist physically alone, or two or more units can be integrated into one unit. The above-integrated units can be implemented in the form of hardware or in the form of software functional units. Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be completed by instructing relevant hardware through a program, and the program can be stored in a computer-readable storage medium. The storage medium can include: read-only memory (ROM, Read Only Memory), random access memory (RAM, Random Access Memory), magnetic disk, or optical disc, etc.

[0094] Those of ordinary skill in the art can understand that all or part of the steps in implementing the methods of the above embodiments can be completed by instructing relevant hardware through a program, and the program can be stored in a computer-readable storage medium. The above-mentioned storage medium can be read-only memory, magnetic disk, or optical disc, etc.

[0095] The above has introduced in detail a computer device provided by the present invention. For those of ordinary skill in the art, according to the idea of the embodiments of the present invention, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation on the present invention.

Claims

1. A method for identifying rare intestinal diseases, characterized in that: include: Obtaining pathological data of the subject; the pathological data includes goblet cells, Pancreatic cells, neutrophils, and plasma cells; The type of rare intestinal disease of the subject is determined based on the pathological data, and the rare intestinal disease types include autoimmune enteropathy and common variable immunodeficiency disease; when the pathological data shows that the goblet cells are less than the preset threshold, the Pancreatic cells are less than the preset threshold, any two or more of the neutrophil infiltrations are present, and the plasma cells remain unchanged, it is determined to be an autoimmune enteropathy; when the pathological data shows that the plasma cells are less than the preset threshold, it is determined to be a common variable immunodeficiency disease.

2. The method for identifying rare intestinal diseases according to claim 1, characterized in that: The pathological data is replaced by the immune protein expression level, and the type of intestinal rare disease is determined based on the immune protein expression level, and the immune protein expression level includes one or more of the following: IgG, IgM, IgA; when the immune protein expression level is greater than a preset threshold, it is determined to be autoimmune enteropathy, otherwise, it is determined to be common variable immunodeficiency disease; Optionally, the pathological data also includes immune protein expression levels. When the pathological data shows that goblet cells are less than a preset threshold, Pancreatic cells are less than a preset threshold, the immune protein expression level is greater than a preset threshold, any two or more of neutrophil infiltrations are present, and plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold and / or the immune protein expression level is less than a preset threshold, it is determined to be common variable immunodeficiency disease.

3. The method for identifying rare intestinal diseases according to claim 1 or 2, characterized in that: The method further includes type classification, wherein the subjects to be tested are classified into types to obtain the classified subjects to be tested; and the types of rare intestinal diseases are determined for the classified subjects to be tested; Optionally, the process of classifying the types is as follows: Obtain clinical data of the subjects; Based on the clinical data, determine whether there is a rare intestinal disease. If chronic diarrhea occurs, it is determined to be a suspected rare intestinal disease; otherwise, it is determined to be further screened for other causes of diseases such as infection and immunity; Obtain intestinal endoscopy data of a subject who is suspected of having a rare intestinal disease, and determine whether the subject has villous atrophy of the small intestine based on the intestinal endoscopy data. If villous atrophy of the small intestine is shown in the intestinal endoscopy, the subject is determined to have villous atrophy of the small intestine; otherwise, the subject is determined to have other intestinal diseases; Acquiring pathological data of a subject diagnosed with villous atrophy of the small intestine, and judging autoimmune enteropathy or common variable immunodeficiency disease based on the pathological data; Optionally, the pathological data are four indicators of the duodenum. When goblet cells are less than a preset threshold, Pancreatic cells are less than a preset threshold, any two or more of neutrophil infiltration appear, and plasma cells remain unchanged, it is judged as autoimmune enteropathy. When the pathological data shows that plasma cells are less than a preset threshold, it is judged as common variable immunodeficiency disease.

4. The method for identifying rare intestinal diseases according to claim 3, characterized in that: The pathological data is replaced by the expression of IgG immunoglobulin, and the autoimmune enteropathy or common variable immunodeficiency disease is judged by the expression of IgG immunoglobulin. When the expression of IgG immunoglobulin is greater than the preset threshold, it is judged as autoimmune enteropathy; otherwise, it is judged as common variable immunodeficiency disease. Optionally, the pathological data is replaced by the expression of IgM immunoglobulin, and the autoimmune enteropathy or common variable immunodeficiency disease is judged by the expression of IgM immunoglobulin. When the expression of IgM immunoglobulin is greater than a preset threshold, it is judged as autoimmune enteropathy; otherwise, it is judged as common variable immunodeficiency disease; Optionally, the pathological data is replaced by the expression level of IgA immunoglobulin, and the autoimmune enteropathy or common variable immunodeficiency disease is judged by the expression level of IgA immunoglobulin. When the expression level of IgA immunoglobulin is greater than a preset threshold, it is judged as autoimmune enteropathy; otherwise, it is judged as common variable immunodeficiency disease.

5. The method for identifying rare intestinal diseases according to claim 3, characterized in that: The determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgG immunoglobulin. When any two or more of the following items appear: goblet cells less than a preset threshold, Paneth cells less than a preset threshold, IgG immunoglobulin expression greater than a preset threshold, and neutrophil infiltration, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data show that the plasma cells are less than a preset threshold and / or the IgG immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease. Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgM immunoglobulin. When any two or more of the following items appear: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, IgM immunoglobulin expression is greater than a preset threshold, and neutrophil infiltration occurs, and plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data show that the plasma cells are less than a preset threshold and / or the IgM immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease. Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgA immunoglobulin. When any two or more of the following items appear: goblet cells are less than a preset threshold, Paneth cells are less than a preset threshold, IgA immunoglobulin expression is greater than a preset threshold, and neutrophil infiltration occurs, and plasma cells remain unchanged, it is determined to be autoimmune enteropathy. When the pathological data show that the plasma cells are less than a preset threshold and / or the IgA immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease. Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgM immunoglobulin and IgG immunoglobulin; when any two or more of the neutrophil infiltration in which the goblet cells are less than a preset threshold, the Pancreatic cells are less than a preset threshold, the IgM immunoglobulin expression is greater than a preset threshold, and the IgG immunoglobulin expression is greater than a preset threshold appears, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy; when the pathological data show any one or more of the plasma cells are less than a preset threshold, the IgM immunoglobulin expression is less than a preset threshold, and the IgG immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease; Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgA immunoglobulin and IgG immunoglobulin; when any two or more of the goblet cells are less than a preset threshold, the Pancreatic cells are less than a preset threshold, the IgA immunoglobulin expression is greater than a preset threshold, and the IgG immunoglobulin expression is greater than a preset threshold, and neutrophil infiltration occurs, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy; when the pathological data show any one or more of the plasma cells are less than a preset threshold, the IgA immunoglobulin expression is less than a preset threshold, and the IgG immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease; Optionally, the determination of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgA immunoglobulin and IgM immunoglobulin; when any two or more of the goblet cells are less than a preset threshold, the Pancreatic cells are less than a preset threshold, the IgM immunoglobulin expression is greater than a preset threshold, and the IgA immunoglobulin expression is greater than a preset threshold, and neutrophil infiltration occurs, and the plasma cells remain unchanged, it is determined to be autoimmune enteropathy; when the pathological data show that any one or more of the plasma cells are less than a preset threshold, the IgM immunoglobulin expression is less than a preset threshold, and the IgA immunoglobulin expression is less than a preset threshold, it is determined to be common variable immunodeficiency disease; Optionally, the judgment of the autoimmune enteropathy or common variable immunodeficiency disease also includes the expression of IgA immunoglobulin, IgM immunoglobulin, and IgG immunoglobulin; when any two or more of neutrophil infiltration occur, including goblet cells less than a preset threshold, Paneth cells less than a preset threshold, IgA immunoglobulin expression greater than a preset threshold, IgM immunoglobulin expression greater than a preset threshold, and IgG immunoglobulin expression greater than a preset threshold, and the plasma cells remain unchanged, it is judged as autoimmune enteropathy; when the pathological data show any one or more of the plasma cells less than a preset threshold, the IgA immunoglobulin expression less than a preset threshold, the IgM immunoglobulin expression less than a preset threshold, and the IgG immunoglobulin expression less than a preset threshold, it is judged as common variable immunodeficiency disease.

6. The method for identifying rare intestinal diseases according to claim 1 or 3, characterized in that: The pathological data is replaced with the second intestinal endoscopy data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined by the second intestinal endoscopy data. When duodenal erosion and / or congestion occurs, it is determined to be autoimmune enteropathy, otherwise, it is determined to be common variable immunodeficiency disease; Optionally, the judgment of autoimmune enteropathy or common variable immunodeficiency disease also includes a second intestinal endoscopy data. The autoimmune enteropathy or common variable immunodeficiency disease is judged by the pathological data and the second intestinal endoscopy data. When any two or more of the goblet cells are less than a preset threshold, the Pancreatic cells are less than a preset threshold, neutrophil infiltration, duodenal erosion and / or congestion occur, it is judged as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than a preset threshold and / or the duodenum is normal, it is judged as common variable immunodeficiency disease.

7. The method for identifying rare intestinal diseases according to claim 1 or 3, characterized in that: The pathological data is replaced by the second clinical data, and the autoimmune enteropathy or common variable immunodeficiency disease is determined by the second clinical data. When the duration of chronic diarrhea is less than a preset threshold, it is determined to be autoimmune enteropathy, otherwise, it is determined to be common variable immunodeficiency disease; Optionally, the duration of chronic diarrhea is replaced by recurrent respiratory tract infections. When recurrent respiratory tract infections occur, it is determined to be common variable immunodeficiency disease, otherwise, it is determined to be autoimmune enteropathy; Optionally, the judgment of the autoimmune enteropathy or common variable immunodeficiency disease also includes a second clinical data. The autoimmune enteropathy or common variable immunodeficiency disease is judged by the pathological data and the second clinical data. When any two or more of the goblet cells are less than a preset threshold, the Pancreatic cells are less than a preset threshold, neutrophil infiltration occurs, and the duration of chronic diarrhea is less than a preset threshold, it is judged as autoimmune enteropathy. When the pathological data shows that the plasma cells are less than the preset threshold and / or the duration of chronic diarrhea is greater than the preset threshold, it is judged as common variable immunodeficiency disease.

8. A computer program product comprising a computer program or instructions, characterized in that: The computer program or instructions are executed by a processor to implement the method for identifying rare intestinal diseases as described in any one of claims 1-7.

9. A computer device comprising a memory, a processor and a computer program or instruction stored in the memory, characterized in that: The computer program or instructions are executed by a processor to implement the method for identifying rare intestinal diseases as described in any one of claims 1-7.

10. A computer-readable storage medium having a computer program or instruction stored thereon, characterized in that: The computer program or instructions are executed by a processor to implement the method for identifying rare intestinal diseases as described in any one of claims 1-7.

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